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Anatomy and Pathology/Oncology

Blunt Eye Trauma: Empirical Histopathologic Paintball Impact Thresholds in Fresh Mounted Porcine Eyes Free
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William E. Sponsel; Walt Gray; Frank W. Scribbick; Amber R. Stern; Carl E. Weiss; Sylvia L. Groth; James D. Walker
Tags: eye, histopathology tests, ocular trauma, suidae, wounds and injuries
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5157-5166. doi:https://doi.org/10.1167/iovs.11-7172
Identification of Multipotent Stem/Progenitor Cells in Murine Sclera Free
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Chia-Ling Tsai; Pei-Chang Wu; M. Elizabeth Fini; Songtao Shi
Tags: mice, sclera, stem cells, reverse transcriptase polymerase chain reaction, mesenchymal stem cells
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5481-5487. doi:https://doi.org/10.1167/iovs.11-7676
Multiplex Ligation-Dependent Probe Amplification Analysis of Uveal Melanoma with Extraocular Extension Demonstrates Heterogeneity of Gross Chromosomal Abnormalities Free
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Sarah L. Lake; Bertil E. Damato; Justyna Dopierala; Maria M. Baudo; Azzam F. G. Taktak; Sarah E. Coupland
Tags: amplification, chromosome abnormality, extension, heterogeneity, ligation
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5559-5564. doi:https://doi.org/10.1167/iovs.10-6845
Multiplex Ligation-Dependent Probe Amplification of Conjunctival Melanoma Reveals Common BRAF V600E Gene Mutation and Gene Copy Number Changes Free
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Sarah L. Lake; Fidan Jmor; Justyna Dopierala; Azzam F. G. Taktak; Sarah E. Coupland; Bertil E. Damato
Tags: amplification, braf gene, gene dosage, ligation, malignant melanoma of conjunctiva
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5598-5604. doi:https://doi.org/10.1167/iovs.10-6934
Anterior Segment Optical Coherence Tomography Analysis of Clinically Unilateral Pseudoexfoliation Syndrome: Evidence of Bilateral Involvement and Morphologic Factors Related to Asymmetry Free
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Xiaodong Zheng; Hiroshi Sakai; Tomoko Goto; Koji Namiguchi; Shiro Mizoue; Atsushi Shiraishi; Shoichi Sawaguchi; Yuichi Ohashi
Tags: exfoliation syndrome, eye, immune reconstitution inflammatory syndrome, iris, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5679-5684. doi:https://doi.org/10.1167/iovs.11-7274
Image Defocus and Altered Retinal Gene Expression in Chick: Clues to the Pathogenesis of Ametropia Free
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Richard A. Stone; Alice M. McGlinn; Donald A. Baldwin; John W. Tobias; P. Michael Iuvone; Tejvir S. Khurana
Tags: gene expression, genes, lens (device), lens, crystalline, refractive errors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5765-5777. doi:https://doi.org/10.1167/iovs.10-6727

Biochemistry and Molecular Biology

Mouse Conjunctival Forniceal Gene Expression during Postnatal Development and Its Regulation by Krüppel-like Factor 4 Free
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Divya Gupta; Stephen A. K. Harvey; Naftali Kaminski; Shivalingappa K. Swamynathan
Tags: conjunctiva, gene expression, mice, goblet cells
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 4951-4962. doi:https://doi.org/10.1167/iovs.10-7068
High Transcriptional Complexity of the Retinitis Pigmentosa CERKL Gene in Human and Mouse Free
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Alejandro Garanto; Marina Riera; Esther Pomares; Jon Permanyer; Marta de Castro-Miró; Florentina Sava; Josep F. Abril; Gemma Marfany; Roser Gonzàlez-Duarte
Tags: exons, genes, mice, protein isoforms, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5202-5214. doi:https://doi.org/10.1167/iovs.10-7101
Transforming Growth Factor–β Induces Extracellular Matrix Protein Cross-Linking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells Free
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Anirudh Sethi; Weiming Mao; Robert J. Wordinger; Abbot F. Clark
Tags: cross-linking, extracellular matrix proteins, genes, protein-lysine 6-oxidase, proteins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5240-5250. doi:https://doi.org/10.1167/iovs.11-7287
Role of TGFβ/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix Proteins Free
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Anirudh Sethi; Ankur Jain; Gulab S. Zode; Robert J. Wordinger; Abbot F. Clark
Tags: proteins, signal transduction, trabecular meshwork, extracellular matrix proteins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5251-5259. doi:https://doi.org/10.1167/iovs.11-7587
Molecular Analysis of Bardet-Biedl Syndrome Families: Report of 21 Novel Mutations in 10 Genes Free
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Jianjun Chen; Nizar Smaoui; Monia Ben Hamed Hammer; Xiaodong Jiao; S. Amer Riazuddin; Shyana Harper; Nicholas Katsanis; Sheikh Riazuddin; Habiba Chaabouni; Eliot L. Berson; J. Fielding Hejtmancik
Tags: mutation, family, genes
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5317-5324. doi:https://doi.org/10.1167/iovs.11-7554
Reversal of Stathmin-Mediated Microtubule Destabilization Sensitizes Retinoblastoma Cells to A Low Dose of Antimicrotubule Agents: A Novel Synergistic Therapeutic Intervention Free
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Moutushy Mitra; Mallikarjuna Kandalam; Curam S. Sundaram; Rama Shenkar Verma; Uma K. Maheswari; Sethuraman Swaminathan; Subramanian Krishnakumar
Tags: rna, small interfering, stathmin, retinoblastoma, vincristine, paclitaxel
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5441-5448. doi:https://doi.org/10.1167/iovs.10-6973
Exaggerated Eye Growth in IRBP-Deficient Mice in Early Development Free
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Jeffrey Wisard; Amanda Faulkner; Micah A. Chrenek; Timothy Waxweiler; Weston Waxweiler; Christy Donmoyer; Gregory I. Liou; Cheryl M. Craft; Gregor F. Schmid; Jeffrey H. Boatright; Machelle T. Pardue; John M. Nickerson
Tags: eye, mice, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5804-5811. doi:https://doi.org/10.1167/iovs.10-7129

Clinical and Epidemiologic Research

Diurnal Variations in Axial Length, Choroidal Thickness, Intraocular Pressure, and Ocular Biometrics Free
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Ranjay Chakraborty; Scott A. Read; Michael J. Collins
Tags: biometry, circadian rhythms, intraocular pressure, eye, vocal cord dysfunction
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5121-5129. doi:https://doi.org/10.1167/iovs.11-7364
Combination of the Schirmer I and Phenol Red Thread Tests as a Rescue Strategy for Diagnosis of Ocular Dryness Associated with Sjögren's Syndrome Free
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Ivan de Monchy; Gaël Gendron; Corinne Miceli; Nicolas Pogorzalek; Xavier Mariette; Marc Labetoulle
Tags: phenolsulfonphthalein, sjogren's syndrome, sensitivity and specificity, simplified acute physiology score
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5167-5173. doi:https://doi.org/10.1167/iovs.10-6671
Refractive Error in Nigerian Adults: Prevalence, Type, and Spectacle Coverage Free
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Christian Ezelum; Hessom Razavi; Selvaraj Sivasubramaniam; Clare E. Gilbert; Gudlavalleti V. S. Murthy; Gabriel Entekume; Tafida Abubakar; Nigeria National Blindness and Visual Impairment Study Group
Tags: adult, myopia, prevalence, refractive errors, eyeglasses
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5449-5456. doi:https://doi.org/10.1167/iovs.10-6770
Subscale Assessment of the NEI-RQL-42 Questionnaire with Rasch Analysis Free
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Colm McAlinden; Eirini Skiadaresi; Jonathan Moore; Konrad Pesudovs
Tags: questionnaires, rasch model, precision, quality of life, refractive errors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5685-5694. doi:https://doi.org/10.1167/iovs.10-67951
Validating the Accuracy of a Model to Predict the Onset of Myopia in Children Free
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Mingzhi Zhang; Gus Gazzard; Zhifu Fu; Liping Li; Bin Chen; Seang Mei Saw; Nathan Congdon
Tags: child, myopia, refractive errors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5836-5841. doi:https://doi.org/10.1167/iovs.10-5592
Nine-Year Incidence and Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study Free
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Satoshi Arakawa; Miho Yasuda; Masaharu Nagata; Toshiharu Ninomiya; Yoichiro Hirakawa; Yasufumi Doi; Yutaka Kiyohara; Tatsuro Ishibashi
Tags: incidence, japanese, kidney failure, chronic, retinal vein occlusion, risk factors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5905-5909. doi:https://doi.org/10.1167/iovs.11-7775
Associations of Complement Factor H and Smoking with Early Age-Related Macular Degeneration: The ALIENOR Study Free
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Cécile Delcourt; Marie-Noëlle Delyfer; Marie-Bénédicte Rougier; Philippe Amouyel; Joseph Colin; Mélanie Le Goff; Florence Malet; Jean-François Dartigues; Jean-Charles Lambert; Jean-François Korobelnik
Tags: age-related macular degeneration, complement factor h, drusen, smoking, cfh y402h
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5955-5962. doi:https://doi.org/10.1167/iovs.10-6235
Dietary Omega-3 Fatty Acids and the Risk for Age-Related Maculopathy: The Alienor Study Free
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Bénédicte Merle; Marie-Noëlle Delyfer; Jean-François Korobelnik; Marie-Bénédicte Rougier; Joseph Colin; Florence Malet; Catherine Féart; Mélanie Le Goff; Jean-François Dartigues; Pascale Barberger-Gateau; Cécile Delcourt
Tags: age-related macular degeneration, diet, omega-3 fatty acids, fatty acids, atrophic condition of skin
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6004-6011. doi:https://doi.org/10.1167/iovs.11-7254
What Is Causing Active Trachoma? The Role of Nonchlamydial Bacterial Pathogens in a Low Prevalence Setting Free
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Matthew J. Burton; Victor H. Hu; Patrick Massae; Sarah E. Burr; Caroline Chevallier; Isaac A. Afwamba; Paul Courtright; Helen A. Weiss; David C. W. Mabey; Robin L. Bailey
Tags: infections, pathogenic organism, prevalence, trachoma, child
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6012-6017. doi:https://doi.org/10.1167/iovs.11-7326
Do Infants Increase the Risk of Re-emergent Infection in Households after Mass Drug Administration for Trachoma? Free
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Sheila K. West; Dianne Stare; Harran Mkocha; Beatriz Munoz; Charlotte Gaydos; Thomas C. Quinn
Tags: infant, infections, trachoma, child
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6040-6042. doi:https://doi.org/10.1167/iovs.11-7372

Cornea

Adaptive Cornea Modeling from Keratometric Data Free
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Andrei Martínez-Finkelshtein; Darío Ramos López; Gracia M. Castro; Jorge L. Alió
Tags: cornea, reconstructive surgical procedures
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 4963-4970. doi:https://doi.org/10.1167/iovs.10-6774
Ocular Lesions in Canine Mucopolysaccharidosis I and Response to Enzyme Replacement Therapy Free
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Kim M. Newkirk; Rosalie M. Atkins; Patti I. Dickson; Barton W. Rohrbach; Michael F. McEntee
Tags: dog, domestic, enzyme replacement therapy, mucopolysaccharidosis i, cornea
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5130-5135. doi:https://doi.org/10.1167/iovs.10-6751
Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis Free
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Andrea Cruzat; Deborah Witkin; Neda Baniasadi; Lixin Zheng; Joseph B. Ciolino; Ula V. Jurkunas; James Chodosh; Deborah Pavan-Langston; Reza Dana; Pedram Hamrah
Tags: cornea, inflammation, keratitis, neurons, nervous system
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5136-5143. doi:https://doi.org/10.1167/iovs.10-7048
Rapid Changes in Connexin-43 in Response to Genotoxic Stress Stabilize Cell–Cell Communication in Corneal Endothelium Free
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Danny S. Roh; James L. Funderburgh
Tags: connexin 43, gap junction protein, stress, cell communication
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5174-5182. doi:https://doi.org/10.1167/iovs.11-7272
In Vivo Confocal Microscopy of Meibomian Glands in Contact Lens Wearers Free
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Edoardo Villani; Gaia Ceresara; Silvia Beretta; Fabrizio Magnani; Francesco Viola; Roberto Ratiglia
Tags: contact lenses, meibomian gland, microscopy, confocal, eyelid margin, mann-whitney u test
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5215-5219. doi:https://doi.org/10.1167/iovs.11-7427
Initial In Vitro Investigation of the Human Immune Response to Corneal Cells from Genetically Engineered Pigs Free
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Hidetaka Hara; Naoko Koike; Cassandra Long; Jordan Piluek; Danny S. Roh; Nirmala SundarRaj; James L. Funderburgh; Yoshiaki Mizuguchi; Kumiko Isse; Carol J. Phelps; Suyapa F. Ball; David L. Ayares; David K. C. Cooper
Tags: cornea, genetic engineering, immune response, suidae, chronic exertional compartment syndrome
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5278-5286. doi:https://doi.org/10.1167/iovs.10-6947
Multiphoton Microscopy of Ex Vivo Corneas after Collagen Cross-Linking Free
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Juan M. Bueno; Emilio J. Gualda; Anastasia Giakoumaki; Pablo Pérez-Merino; Susana Marcos; Pablo Artal
Tags: cornea, corneal collagen cross-linking, riboflavin, diagnostic imaging
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5325-5331. doi:https://doi.org/10.1167/iovs.11-7184
Hyperosmolar Stress Upregulates HLA-DR Expression in Human Conjunctival Epithelium in Dry Eye Patients and In Vitro Models Free
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Piera Versura; Vincenzo Profazio; Costantino Schiavi; Emilio C. Campos
Tags: conjunctiva, hla-dr antigens, hyperosmolality, hyperosmolar hyperglycemia, stress
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5488-5496. doi:https://doi.org/10.1167/iovs.11-7215
Polycystin-2 Expression and Function in Adult Mouse Lacrimal Acinar Cells Free
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Simon Kaja; Jill D. Hilgenberg; Volodymyr Rybalchenko; Wanda E. Medina-Ortiz; Elaine V. Gregg; Peter Koulen
Tags: acinar cells, adult, lacrimal gland, mice, antibodies
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5605-5611. doi:https://doi.org/10.1167/iovs.10-7114
Corneal Endothelial Autocrine VIP Enhances Its Integrity in Stored Human Donor Corneoscleral Explant Free
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Shay-Whey M. Koh; Dante Gloria; Joseph Molloy
Tags: cornea, donors, ciliary neurotrophic factor, personal integrity, autocrine
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5632-5640. doi:https://doi.org/10.1167/iovs.10-5983
Notch Signaling Modulates MUC16 Biosynthesis in an In Vitro Model of Human Corneal and Conjunctival Epithelial Cell Differentiation Free
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Linjie Xiong; Ashley M. Woodward; Pablo Argüeso
Tags: biosynthesis, conjunctival epithelial cells, cornea, mucins, signal transduction
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5641-5646. doi:https://doi.org/10.1167/iovs.11-7196
Interaction of α1D-Adrenergic and P2X7 Receptors in the Rat Lacrimal Gland and the Effect on Intracellular [Ca2+] and Protein Secretion Free
PDF
Darlene A. Dartt; Robin R. Hodges
Tags: agonists, lacrimal gland, protein secretion, phenylephrine
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5720-5729. doi:https://doi.org/10.1167/iovs.11-7358
Blockade of Insulin Receptor Substrate-1 Inhibits Corneal Lymphangiogenesis Free
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Deniz Hos; Birgit Regenfuss; Felix Bock; Jasmine Onderka; Claus Cursiefen
Tags: cornea, irs1 protein, human, lymphangiogenesis, macrophages, insulin receptor
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5778-5785. doi:https://doi.org/10.1167/iovs.10-6816
Grading Bulbar Redness Using Cross-Calibrated Clinical Grading Scales Free
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Marc M. Schulze; Natalie Hutchings; Trefford L. Simpson
Tags: weight measurement scales
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5812-5817. doi:https://doi.org/10.1167/iovs.10-7006
Activation of MAPK Signaling Pathway and NF-κB Activation in Pterygium and Ipsilateral Pterygium-Free Conjunctival Specimens Free
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Jenice Torres; Amalia Enríquez-de-Salamanca; Itziar Fernández; Maria Teresa Rodríguez-Ares; Maria J. Quadrado; Joaquim Murta; José M. Benítez del Castillo; Michael E. Stern; Margarita Calonge
Tags: conjunctiva, mitogen-activated protein kinases, pterygium
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5842-5852. doi:https://doi.org/10.1167/iovs.10-6673
Comparison of the Ocular Response Analyzer and the Goldmann Applanation Tonometer for Measuring Intraocular Pressure after Deep Anterior Lamellar Keratoplasty Free
PDF
Sepehr Feizi; Ali Hashemloo; Ali Rastegarpour
Tags: intraocular pressure, keratoplasty, tonometers, tissue transplants, cornea
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5887-5891. doi:https://doi.org/10.1167/iovs.10-6771
The OV-TL 12/30 Clone of Anti-cytokeratin 7 Antibody as a New Marker of Corneal Conjunctivalization in Patients with Limbal Stem Cell Deficiency Free
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Katerina Jirsova; Lubica Dudakova; Sarka Kalasova; Viera Vesela; Stanislava Merjava
Tags: antibodies, clone cells, conjunctiva, cornea, keratin 7
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5892-5898. doi:https://doi.org/10.1167/iovs.10-6748
Morphologic and Confocal Investigation on Salzmann Nodular Degeneration of the Cornea Free
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Anna M. Roszkowska; Pasquale Aragona; Rosaria Spinella; Antonina Pisani; Domenico Puzzolo; Antonio Micali
Tags: cornea, tissue degeneration, epithelium
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5910-5919. doi:https://doi.org/10.1167/iovs.11-7789
Pan-Corneal Endothelial Viability Assessment: Application to Endothelial Grafts Predissected by Eye Banks Free
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Aurélien Pipparelli; Gilles Thuret; David Toubeau; Zhiguo He; Simone Piselli; Sabine Lefèvre; Philippe Gain; Marc Muraine
Tags: cornea, endothelium, eye banks, tissue transplants
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6018-6025. doi:https://doi.org/10.1167/iovs.10-6641
Corneal Sensitivity in Diabetic Patients Subjected to Retinal Laser Photocoagulation Free
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Waldir Neira-Zalentein; Juha M. Holopainen; Timo M. T. Tervo; Fernando Borrás; M. Carmen Acosta; Carlos Belmonte; Juana Gallar
Tags: cornea, diabetes mellitus, lasers, light coagulation, common cold
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6043-6049. doi:https://doi.org/10.1167/iovs.10-7054
Dynamic Changes in Ocular Zernike Aberrations and Tear Menisci Measured with a Wavefront Sensor and an Anterior Segment OCT Free
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Jingjing Xu; Jinhua Bao; Jun Deng; Fan Lu; Ji C. He
Tags: knee meniscus, sensor, tear film finding, eye, coma
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6050-6056. doi:https://doi.org/10.1167/iovs.10-7102

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Rapid, High-Accuracy Detection of Strabismus and Amblyopia Using the Pediatric Vision Scanner Free
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Sjoukje E. Loudon; Caitlin A. Rook; Deborah S. Nassif; Nadya V. Piskun; David G. Hunter
Tags: amblyopia, pediatrics, strabismus, vision, child
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5043-5048. doi:https://doi.org/10.1167/iovs.11-7503
Retrobulbar Ocular Blood Flow Changes after Orbital Decompression in Graves' Ophthalmopathy Measured by Color Doppler Imaging Free
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Marta Pérez-López; Marco Sales-Sanz; Gema Rebolleda; Pilar Casas-Llera; Cristina González-Gordaliza; Elena Jarrín; Francisco José Muñoz-Negrete
Tags: clinically isolated syndrome, decompression, external, decompressive incision, diagnostic imaging, doppler color flow
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5612-5617. doi:https://doi.org/10.1167/iovs.10-6907
Automated Perimetry: Using Gaze-Direction Data to Improve the Estimate of Scotoma Edges Free
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Harry J. Wyatt
Tags: gaze, perimetry, scotoma, retinal blind spot, eye
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5818-5823. doi:https://doi.org/10.1167/iovs.10-6398
Effects of Anisometropic Amblyopia on Visuomotor Behavior, III: Temporal Eye-Hand Coordination during Reaching Free
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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Manokaraananthan Chandrakumar; Zahra Hirji; Agnes M. F. Wong
Tags: amblyopia, anisometropic amblyopia, eye, eye-hand coordination, saccades
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5853-5861. doi:https://doi.org/10.1167/iovs.11-7314

Genetics

Linkage Analysis of Quantitative Refraction and Refractive Errors in the Beaver Dam Eye Study Free
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Alison P. Klein; Priya Duggal; Kristine E. Lee; Ching-Yu Cheng; Ronald Klein; Joan E. Bailey-Wilson; Barbara E. K. Klein
Tags: eye, genetic linkage analysis, myopia, refraction, refractive errors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5220-5225. doi:https://doi.org/10.1167/iovs.10-7096
A Homozygous Frameshift Mutation in BEST1 Causes the Classical Form of Best Disease in an Autosomal Recessive Mode Free
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Hanna Bitner; Liliana Mizrahi-Meissonnier; Gabriel Griefner; Inbar Erdinest; Dror Sharon; Eyal Banin
Tags: autosomal recessive inheritance, frameshift mutation function, homozygote, vitelliform dystrophy, mutation
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5332-5338. doi:https://doi.org/10.1167/iovs.11-7174
Regional and Temporal Differences in Gene Expression of LHBETATAG Retinoblastoma Tumors Free
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Samuel K. Houston; Yolanda Pina; Jennifer Clarke; Tulay Koru-Sengul; William K. Scott; Lubov Nathanson; Amy C. Schefler; Timothy G. Murray
Tags: gene expression, neoplasms, retinoblastoma
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5359-5368. doi:https://doi.org/10.1167/iovs.10-6321
Evaluation of Serum Lipid Concentrations and Genetic Variants at High-Density Lipoprotein Metabolism Loci and TIMP3 in Age-Related Macular Degeneration Free
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Sascha Fauser; Dzenita Smailhodzic; Albert Caramoy; Johannes P.H. van de Ven; Bernd Kirchhof; Carel B. Hoyng; B. Jeroen Klevering; Sandra Liakopoulos; Anneke I. den Hollander
Tags: age-related macular degeneration, genetics, high density lipoproteins, lipids, metabolism
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5525-5528. doi:https://doi.org/10.1167/iovs.10-6827
Ophthalmic Phenotypes and the Representativeness of Twin Data for the General Population Free
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Paul G. Sanfilippo; Sarah E. Medland; Alex W. Hewitt; Lisa S. Kearns; Jonathan B. Ruddle; Cong Sun; Christopher J. Hammond; Terri L. Young; Nicholas G. Martin; David A. Mackey
Tags: eye, phenotype, relationship - sibling, twins, birth weight
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5565-5572. doi:https://doi.org/10.1167/iovs.11-7258
Association of TCF4 Gene Polymorphisms with Fuchs' Corneal Dystrophy in the Chinese Free
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Anbupalam Thalamuthu; Chiea Chuen Khor; Divya Venkataraman; Li Wei Koh; Donald T. H. Tan; Tin Aung; Jodhbir S. Mehta; Eranga N. Vithana
Tags: chinese people, genes, hereditary corneal dystrophy, polymorphism, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5573-5578. doi:https://doi.org/10.1167/iovs.11-7568
Gene Expression Profiling of Early-Phase Sjögren's Syndrome in C57BL/6.NOD-Aec1Aec2 Mice Identifies Focal Adhesion Maturation Associated with Infiltrating Leukocytes Free
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Ammon B. Peck; Benjamin T. Saylor; Linh Nguyen; Ashok Sharma; Jin-Xiong She; Cuong Q. Nguyen; Richard A. McIndoe
Tags: focal adhesions, gene expression profiling, genes, leukocytes, mice
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5647-5655. doi:https://doi.org/10.1167/iovs.11-7652

Glaucoma

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility Free
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Kate E. Keller; John M. Bradley; Janice A. Vranka; Ted S. Acott
Tags: biosynthesis, eye, fluid flow, immunohistochemistry, infections
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5049-5057. doi:https://doi.org/10.1167/iovs.10-6948
Structural Correlation Between the Nerve Fiber Layer and Retinal Ganglion Cell Loss in Mice with Targeted Disruption of the Brn3b Gene Free
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Andrew S. Camp; Marco Ruggeri; Gustavo C. Munguba; Mary L. Tapia; Simon W.M. John; Sanjoy K. Bhattacharya; Richard K. Lee
Tags: cell count, genes, mice, nerve fibers, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5226-5232. doi:https://doi.org/10.1167/iovs.10-6307
During Glaucoma, α2-Macroglobulin Accumulates in Aqueous Humor and Binds to Nerve Growth Factor, Neutralizing Neuroprotection Free
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Yujing Bai; Delia Sivori; Sang B. Woo; Kenneth E. Neet; S. Fabian Lerner; H. Uri Saragovi
Tags: aqueous humor, binding (molecular function), glaucoma, intraocular pressure, macroglobulins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5260-5265. doi:https://doi.org/10.1167/iovs.10-6691
An Applet to Estimate the IOP-Induced Stress and Strain within the Optic Nerve Head Free
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Ian A. Sigal
Tags: intraocular pressure, optic disk, stress, eye
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5497-5506. doi:https://doi.org/10.1167/iovs.10-7141
Biomechanical Changes in the Sclera of Monkey Eyes Exposed to Chronic IOP Elevations Free
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Michaël J. A. Girard; J.-K. Francis Suh; Michael Bottlang; Claude F. Burgoyne; J. Crawford Downs
Tags: cercopithecidae, eye, intraocular pressure, sclera, glaucoma
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5656-5669. doi:https://doi.org/10.1167/iovs.10-6927

Immunology and Microbiology

Preventive Effects of Ethyl Pyruvate on Endotoxin-Induced Uveitis in Rats Free
PDF
Nilesh M. Kalariya; Aramati B. M. Reddy; Naseem H. Ansari; Frederik J. G. M. VanKuijk; Kota V. Ramana
Tags: chemokines, cytokine, endotoxins, eye, prevention
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5144-5152. doi:https://doi.org/10.1167/iovs.10-7047
The Effectiveness of Various Cleaning Regimens and Current Guidelines in Contact Lens Case Biofilm Removal Free
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Yvonne T. Wu; Hua Zhu; Mark Willcox; Fiona Stapleton
Tags: biofilms, contact lens storage case, guidelines, body tissue
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5287-5292. doi:https://doi.org/10.1167/iovs.10-6785
Testican-1 Promotes Resistance against Pseudomonas aeruginosa–Induced Keratitis through Regulation of MMP-2 Expression and Activation Free
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Elizabeth A. Berger; Sharon A. McClellan; Ronald P. Barrett; Linda D. Hazlett
Tags: gelatinase a, mice, keratitis, proteins, cornea
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5339-5346. doi:https://doi.org/10.1167/iovs.10-6920
Diversity of Bacteria at Healthy Human Conjunctiva Free
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Qunfeng Dong; Jennifer M. Brulc; Alfonso Iovieno; Brandon Bates; Aaron Garoutte; Darlene Miller; Kashi V. Revanna; Xiang Gao; Dionysios A. Antonopoulos; Vladlen Z. Slepak; Valery I. Shestopalov
Tags: bacteria, conjunctiva, rna, ribosomal, 16s, microbiome, dna
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5408-5413. doi:https://doi.org/10.1167/iovs.10-6939
Protective Effect of Intravitreal Administration of Tresperimus, an Immunosuppressive Drug, on Experimental Autoimmune Uveoretinitis Free
PDF
Elodie Bousquet; Serge Camelo; Guillaume Leroux les Jardins; Brigitte Goldenberg; Marie-Christine Naud; Bernadette Besson-Lescure; Luc Lebreton; Jocelyne Annat; Francine Behar-Cohen; Yvonne de Kozak
Tags: aqueous humor, autoimmune diseases, autoimmunity, cytokine, immunization
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5414-5423. doi:https://doi.org/10.1167/iovs.10-6740
Effects of Interleukin-1 Receptor Antagonist on Tumor Stroma in Experimental Uveal Melanoma Free
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Pierre L. Triozzi; Wayne Aldrich; Arun Singh
Tags: interleukin-1 receptor antagonists, neoplasms, uveal melanoma, interleukin-1
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5529-5535. doi:https://doi.org/10.1167/iovs.10-6331
Activated γδ T Cells Promote the Activation of Uveitogenic T Cells and Exacerbate EAU Development Free
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Hong Nian; Hui Shao; Rebecca L. O'Brien; Willi K. Born; Henry J. Kaplan; Deming Sun
Tags: t-lymphocytes, interleukin-17, symptom aggravating factors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5920-5927. doi:https://doi.org/10.1167/iovs.10-6758

Lens

Aquaporin-0 Interacts with the FERM Domain of Ezrin/Radixin/Moesin Proteins in the Ocular Lens Free
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Zhen Wang; Kevin L. Schey
Tags: lens, crystalline, peptides, proteins, water channels, lens (device)
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5079-5087. doi:https://doi.org/10.1167/iovs.10-6998
Potential Therapeutic Efficacy of a Virtual Pupil Made of Polarizing Plates for Correction of Aniridia Free
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Masayuki Akimoto; Kikuo Mitomo
Tags: aniridia, bone plates, eye, artificial, pupil, iris
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5153-5156. doi:https://doi.org/10.1167/iovs.10-6913
Overexpression of Human γC-crystallin 5 bp Duplication Disrupts Lens Morphology in Transgenic Mice Free
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Zhiwei Ma; Wenliang Yao; Veena Theendakara; Chi-Chao Chan; Eric Wawrousek; J. Fielding Hejtmancik
Tags: crystallins, language morphology, lens (device), lens, crystalline, mice, transgenic
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5369-5375. doi:https://doi.org/10.1167/iovs.11-7168

Low Vision

Risk of Falls, Injurious Falls, and Other Injuries Resulting from Visual Impairment among Older Adults with Age-Related Macular Degeneration Free
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Joanne M. Wood; Philippe Lacherez; Alex A. Black; Michael H. Cole; Mei Ying Boon; Graham K. Kerr
Tags: age-related macular degeneration, fall risks, older adult, visual impairment, wounds and injuries
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5088-5092. doi:https://doi.org/10.1167/iovs.10-6644
Factors Influencing Self-reported Vision-Related Activity Limitation in the Visually Impaired Free
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Daryl R. Tabrett; Keziah Latham
Tags: self-report, vision
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5293-5302. doi:https://doi.org/10.1167/iovs.10-7055

Multidisciplinary Ophthalmic Imaging

Visualization of Fundus Vessel Pulsation Using Principal Component Analysis Free
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Fabrice Moret; Charlotte M. Poloschek; Wolf A. Lagrèze; Michael Bach
Tags: principal component analysis, asbestos, serpentine
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5457-5464. doi:https://doi.org/10.1167/iovs.10-6806
Reproducibility of Retinal and Choroidal Thickness Measurements in Enhanced Depth Imaging and High-Penetration Optical Coherence Tomography Free
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Yasushi Ikuno; Ichiro Maruko; Yoshiaki Yasuno; Masahiro Miura; Tetsuju Sekiryu; Kohji Nishida; Tomohiro Iida
Tags: diagnostic imaging, optical coherence tomography, choroid
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5536-5540. doi:https://doi.org/10.1167/iovs.10-6811
Energy Distribution between Distance and Near Images in Apodized Diffractive Multifocal Intraocular Lenses Free
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Fidel Vega; Francisco Alba-Bueno; María S. Millán
Tags: diameter, intraocular lens implant device, intraocular lens implantation procedure, pupil, mydriasis
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5695-5701. doi:https://doi.org/10.1167/iovs.10-7123
Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes Free
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Gabriela S. Seiler; Jacklyn H. Salmon; Rebecca Mantuo; Steven Feingold; Paul A. Dayton; Brian C. Gilger
Tags: contrast media, diagnostic imaging, dilatation, pathologic, eye, ultrasonography
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5730-5736. doi:https://doi.org/10.1167/iovs.11-7525

Physiology and Pharmacology

Blockade of NADPH Oxidase Restores Vasoreparative Function in Diabetic CD34+ Cells Free
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Yagna P. R. Jarajapu; Sergio Caballero; Amrisha Verma; Takahiko Nakagawa; Margaret C. Lo; Qiuhong Li; Maria B. Grant
Tags: cd34 antigens, diabetes mellitus, nadph oxidases
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5093-5104. doi:https://doi.org/10.1167/iovs.10-70911
Kappa Opioid Receptor Localization and Coupling to Nitric Oxide Production in Cells of the Anterior Chamber Free
PDF
Karen R. Russell-Randall; Juanita Dortch-Carnes
Tags: anterior chamber of eye, nitric oxide, receptors, opioid, kappa, agonists, intraocular pressure
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5233-5239. doi:https://doi.org/10.1167/iovs.10-6613
Lamina-Specific Functional MRI of Retinal and Choroidal Responses to Visual Stimuli Free
PDF
Yen-Yu I. Shih; Bryan H. De La Garza; Eric R. Muir; William E. Rogers; Joseph M. Harrison; Jeffrey W. Kiel; Timothy Q. Duong
Tags: functional magnetic resonance imaging, photic stimulation, photopsia, magnetic resonance imaging, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5303-5310. doi:https://doi.org/10.1167/iovs.10-6438
Swelling-Activated Potassium Channel in Porcine Pigmented Ciliary Epithelial Cells Free
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Masayuki Takahira; Mayumi Sakurai; Norimasa Sakurada; Kazuhisa Sugiyama
Tags: edema, epithelial cells, potassium channel, suidae, voltage
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5928-5932. doi:https://doi.org/10.1167/iovs.11-7173

Retina

Macular Choroidal Thickness and Volume in Normal Subjects Measured by Swept-Source Optical Coherence Tomography Free
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Masaya Hirata; Akitaka Tsujikawa; Akiko Matsumoto; Masanori Hangai; Sotaro Ooto; Kenji Yamashiro; Masahiro Akiba; Nagahisa Yoshimura
Tags: optical coherence tomography, volume, choroid, eye, macula densa
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 4971-4978. doi:https://doi.org/10.1167/iovs.11-7729
Mechanism of Voriconazole-Induced Transient Visual Disturbance: Reversible Dysfunction of Retinal ON-Bipolar Cells in Monkeys Free
PDF
Junzo Kinoshita; Noriaki Iwata; Mitsuhiro Ohba; Tomofumi Kimotsuki; Mitsuya Yasuda
Tags: cercopithecidae, vision disorders, voriconazole, pathophysiology
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5058-5063. doi:https://doi.org/10.1167/iovs.11-7183
Retinal Oxygen Saturation in Patients with Systemic Hypoxemia Free
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Sindri Traustason; Annette Schophuus Jensen; Henrik Sven Arvidsson; Inger Christine Munch; Lars Søndergaard; Michael Larsen
Tags: eisenmenger complex, hypoxemia, oxygen saturation measurement, oximetry
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5064-5067. doi:https://doi.org/10.1167/iovs.11-7275
Foveal Shape and Structure in a Normal Population Free
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Sarah Tick; Florence Rossant; Itebeddine Ghorbel; Alain Gaudric; José-Alain Sahel; Philippe Chaumet-Riffaud; Michel Paques
Tags: eye, fluorescein angiography, fovea centralis, language morphology, morphology
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5105-5110. doi:https://doi.org/10.1167/iovs.10-7005
Understanding Clinically Undetected Macular Changes in Early Retinopathy of Prematurity on Spectral Domain Optical Coherence Tomography Free
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Anand Vinekar; Kavitha Avadhani; Munusamy Sivakumar; Padmamalini Mahendradas; Mathew Kurian; Sherine Braganza; Rohit Shetty; Bhujang K. Shetty
Tags: comprehension, eye, infant, optical coherence tomography, retinopathy of prematurity
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5183-5188. doi:https://doi.org/10.1167/iovs.10-7155
Adult Donor Rod Photoreceptors Integrate into the Mature Mouse Retina Free
PDF
Juliane Gust; Thomas A. Reh
Tags: adult, donors, mice, photoreceptors, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5266-5272. doi:https://doi.org/10.1167/iovs.10-6329
Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography Free
PDF
Marieh Esmaeelpour; Boris Považay; Boris Hermann; Bernd Hofer; Vedran Kajic; Sarah L. Hale; Rachel V. North; Wolfgang Drexler; Nik J. L. Sheen
Tags: choroid, diabetes mellitus, diabetes mellitus, type 2, eye, macular disorders
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5311-5316. doi:https://doi.org/10.1167/iovs.10-6875
Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a Free
PDF
Karine Zaniolo; Przemyslaw Sapieha; Zhuo Shao; Andreas Stahl; Tang Zhu; Sophie Tremblay; Emilie Picard; Ankush Madaan; Martine Blais; Pierre Lachapelle; Joseph Mancini; Pierre Hardy; Lois E. H. Smith; Huy Ong; Sylvain Chemtob
Tags: ghrelin, angiogenesis, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5376-5386. doi:https://doi.org/10.1167/iovs.10-7152
Sclera-Choroid-RPE Transport of Eight β-Blockers in Human, Bovine, Porcine, Rabbit, and Rat Models Free
PDF
Rajendra S. Kadam; Narayan P. S. Cheruvu; Henry F. Edelhauser; Uday B. Kompella
Tags: biological transport, body tissue, cattle, oryctolagus cuniculus, sclera
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5387-5399. doi:https://doi.org/10.1167/iovs.10-6233
Effect of Brimonidine on Retinal and Choroidal Neovascularization in a Mouse Model of Retinopathy of Prematurity and Laser-Treated Rats Free
PDF
Jyotirmoy Kusari; Edwin Padillo; Sheila X. Zhou; Yanyan Bai; Juanjuan Wang; Zhiming Song; Meili Zhu; Yun-Zheng Le; Daniel W. Gil
Tags: choroidal neovascularization, lasers, mice, brimonidine, rats
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5424-5431. doi:https://doi.org/10.1167/iovs.10-6262
Development of Emulsification-Resistant Silicone Oils: Can We Go Beyond 2000 mPas Silicone Oil? Free
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Albert Caramoy; Nadine Hagedorn; Sascha Fauser; Wilfried Kugler; Theresia Groß; Bernd Kirchhof
Tags: emulsification, silicone oils
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5432-5436. doi:https://doi.org/10.1167/iovs.11-7250
Bilateral Patching in Retinal Detachment: Fluid Mechanics and Retinal “Settling” Free
PDF
William J. Foster
Tags: fluid mechanics, retinal detachment, traction, retinal perforations, vitreous body
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5437-5440. doi:https://doi.org/10.1167/iovs.11-7249
Comparison of Ocular Pathologies in Vitamin A–Deficient Mice and RPE65 Gene Knockout Mice Free
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Yang Hu; Ying Chen; Gennadiy Moiseyev; Yusuke Takahashi; Robert Mott; Jian-xing Ma
Tags: mice, vitamin a, gene knockout techniques, retinoids, retinal cone
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5507-5514. doi:https://doi.org/10.1167/iovs.10-7118
High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy Free
PDF
Sotaro Ooto; Masanori Hangai; Kohei Takayama; Naoko Arakawa; Akitaka Tsujikawa; Hideki Koizumi; Susumu Oshima; Nagahisa Yoshimura
Tags: diagnostic imaging, eye, optics, photoreceptors, retinal cone
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5541-5550. doi:https://doi.org/10.1167/iovs.11-7251
Spectral-Domain Optical Coherence Tomography as an Indicator of Fluorescein Angiography Leakage from Choroidal Neovascularization Free
PDF
Andrea Giani; Cristiano Luiselli; Daniel D. Esmaili; Paola Salvetti; Mario Cigada; Joan W. Miller; Giovanni Staurenghi
Tags: choroidal neovascularization, fluorescein angiography, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5579-5586. doi:https://doi.org/10.1167/iovs.10-6617
Evaluation of Italian Patients with Leber Congenital Amaurosis due to AIPL1 Mutations Highlights the Potential Applicability of Gene Therapy Free
PDF
Francesco Testa; Enrico Maria Surace; Settimio Rossi; Elena Marrocco; Annagiusi Gargiulo; Valentina Di Iorio; Carmela Ziviello; Anna Nesti; Simona Fecarotta; Maria Laura Bacci; Massimo Giunti; Michele della Corte; Sandro Banfi; Alberto Auricchio; Francesca Simonelli
Tags: gene therapy, italian, leber's amaurosis, mice, mutation
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5618-5624. doi:https://doi.org/10.1167/iovs.10-6543
Copy-Number Variations in EYS: A Significant Event in the Appearance of arRP Free
PDF
Juan I. Pieras; Isabel Barragán; Salud Borrego; Isabelle Audo; María González-Del Pozo; Sara Bernal; Montserrat Baiget; Christina Zeitz; Shomi S. Bhattacharya; Guillermo Antiñolo
Tags: cohort studies, exons, family, genes, mutation
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5625-5631. doi:https://doi.org/10.1167/iovs.11-7292
Increased Expression of Periostin in Vitreous and Fibrovascular Membranes Obtained from Patients with Proliferative Diabetic Retinopathy Free
PDF
Shigeo Yoshida; Keijiro Ishikawa; Ryo Asato; Mitsuru Arima; Yukio Sassa; Ayako Yoshida; Hiroshi Yoshikawa; Keisuke Narukawa; Satoshi Obika; Junya Ono; Shoichiro Ohta; Kenji Izuhara; Toshihiro Kono; Tatsuro Ishibashi
Tags: proliferative diabetic retinopathy, tissue membrane, vitreous body, polymerase chain reaction, proteins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5670-5678. doi:https://doi.org/10.1167/iovs.10-6625
Technetium-99 Conjugated with Methylene Diphosphonate (99Tc-MDP) Inhibits Experimental Choroidal Neovascularization In Vivo and VEGF-Induced Cell Migration and Tube Formation In Vitro Free
PDF
Kunbei Lai; Li Xu; Chenjin Jin; Kaili Wu; Zhen Tian; Chuangxin Huang; Xiaojing Zhong; Haiyun Ye
Tags: cell motility, choroidal neovascularization, gelatinase a, vascular endothelial growth factor a, bisphosphonates
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5702-5712. doi:https://doi.org/10.1167/iovs.10-6370
AAV-Mediated Gene Replacement, Either Alone or in Combination with Physical and Pharmacological Agents, Results in Partial and Transient Protection from Photoreceptor Degeneration Associa... Free
PDF
Mariacarmela Allocca; Anna Manfredi; Carolina Iodice; Umberto Di Vicino; Alberto Auricchio
Tags: genes, mice, pharmaceutical preparations, photoreceptors, spatial vectors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5713-5719. doi:https://doi.org/10.1167/iovs.10-6269
Significant Correlation between Electroretinogram Parameters and Ocular Vascular Endothelial Growth Factor Concentration in Central Retinal Vein Occlusion Eyes Free
PDF
Shunsuke Yasuda; Shu Kachi; Mineo Kondo; Hiroaki Ushida; Ruka Uetani; Takayuki Terui; Chang-Hua Piao; Hiroko Terasaki
Tags: electroretinography, eye, mass or substance concentration per volume, vascular endothelial growth factor a, central retinal vein occlusion
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5737-5742. doi:https://doi.org/10.1167/iovs.10-6923
Image Registration and Multimodal Imaging of Reticular Pseudodrusen Free
PDF
Mahsa A. Sohrab; R. Theodore Smith; Hani Salehi-Had; SriniVas R. Sadda; Amani A. Fawzi
Tags: diagnostic imaging, face
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5743-5748. doi:https://doi.org/10.1167/iovs.10-6942
Role of the Intravitreal Growth Factors in the Pathogenesis of Idiopathic Epiretinal Membrane Free
PDF
Ludovico Iannetti; Massimo Accorinti; Romualdo Malagola; Francesco Bozzoni-Pantaleoni; Stefano Da Dalt; Ferdinando Nicoletti; Roberto Gradini; Anna Traficante; Michelangelo Campanella; Paola Pivetti-Pezzi
Tags: epiretinal membrane, growth factor, pathogenesis
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5786-5789. doi:https://doi.org/10.1167/iovs.10-7116
An Experimental Study of Retinal Endovascular Surgery with a Microfabricated Needle Free
PDF
Kazuaki Kadonosono; Akira Arakawa; Shin Yamane; Eiichi Uchio; Yasuo Yanagi
Tags: central retinal vein, endoluminal repair, endovascular procedures, experimental study, eye
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5790-5793. doi:https://doi.org/10.1167/iovs.11-7327
The Role of TLR4 Activation in Photoreceptor Mitochondrial Oxidative Stress Free
PDF
MinHee K. Ko; Sindhu Saraswathy; Jignesh G. Parikh; Narsing A. Rao
Tags: dna, mitochondrial, immune response, mice, mitochondria, oxidative stress
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5824-5835. doi:https://doi.org/10.1167/iovs.10-6357
Automatic Detection of Diabetic Retinopathy and Age-Related Macular Degeneration in Digital Fundus Images Free
PDF
Carla Agurto; E. Simon Barriga; Victor Murray; Sheila Nemeth; Robert Crammer; Wendall Bauman; Gilberto Zamora; Marios S. Pattichis; Peter Soliz
Tags: age-related macular degeneration, diabetic retinopathy, radioimmunosorbent test, retina, neovascularization, pathologic
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5862-5871. doi:https://doi.org/10.1167/iovs.10-7075
PET/CT Imaging of I-124–Radiolabeled Bevacizumab and Ranibizumab after Intravitreal Injection in a Rabbit Model Free
PDF
John B. Christoforidis; Michelle M. Carlton; Michael V. Knopp; George H. Hinkle
Tags: bevacizumab, computed tomography/positron emission tomography imaging, diagnostic imaging, intravitreal injections, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5899-5903. doi:https://doi.org/10.1167/iovs.10-6862

Retinal Cell Biology

Comparison of FRPE and Human Embryonic Stem Cell–Derived RPE Behavior on Aged Human Bruch's Membrane Free
PDF
Ilene K. Sugino; Qian Sun; Jianqiu Wang; Celia F. Nunes; Noounanong Cheewatrakoolpong; Aprille Rapista; Adam C. Johnson; Christopher Malcuit; Irina Klimanskaya; Robert Lanza; Marco A. Zarbin
Tags: bruch's basal membrane, hetastarch, primary eosinophilic endomyocardial cardiomyopathy, embryonic stem cells, donors
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 4979-4997. doi:https://doi.org/10.1167/iovs.10-5386
Tauroursodeoxycholic Acid Prevents Retinal Degeneration in Transgenic P23H Rats Free
PDF
Laura Fernández-Sánchez; Pedro Lax; Isabel Pinilla; José Martín-Nieto; Nicolás Cuenca
Tags: animals, transgenic, photoreceptors, rats, retinal degeneration, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 4998-5008. doi:https://doi.org/10.1167/iovs.11-7496
Regulation of Fibronectin-EDA through CTGF Domain–Specific Interactions with TGFβ2 and Its Receptor TGFβRII Free
PDF
Rima Khankan; Noelynn Oliver; Shikun He; Stephen J. Ryan; David R. Hinton
Tags: connective tissue growth factor, retinal pigment cell, proteins, fibronectins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5068-5078. doi:https://doi.org/10.1167/iovs.11-7191
Early Onset and Differential Temporospatial Expression of Melanopsin Isoforms in the Developing Chicken Retina Free
PDF
Daniela M. Verra; Maria Ana Contín; David Hicks; Mario E. Guido
Tags: chickens, melanopsin, protein isoforms, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5111-5120. doi:https://doi.org/10.1167/iovs.11-75301
Misexpression of the Constitutive Rpgrex1-19 Variant Leads to Severe Photoreceptor Degeneration Free
PDF
Rachel N. Wright; Dong-Hyun Hong; Brian Perkins
Tags: mice, mice, transgenic, photoreceptors, proteins, retina
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5189-5201. doi:https://doi.org/10.1167/iovs.11-7470
Analysis of Complement Expression in Light-Induced Retinal Degeneration: Synthesis and Deposition of C3 by Microglia/Macrophages Is Associated with Focal Photoreceptor Degeneration Free
PDF
Matt Rutar; Riccardo Natoli; Peter Kozulin; Krisztina Valter; Paul Gatenby; Jan M. Provis
Tags: complement system proteins, macrophages, microglia, photoreceptors, retinal degeneration
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5347-5358. doi:https://doi.org/10.1167/iovs.10-7119
Endogenic Regulation of Proliferation and Zinc Transporters by Pigment Epithelial Cells Nonvirally Transfected with PEDF Free
PDF
Sandra Johnen; Olga Kazanskaya; Narendra Armogan; Christiane Stickelmann; Michael Stöcker; Peter Walter; Gabriele Thumann
Tags: epithelial cells, pigment, regulation, zinc transporter, bodily secretions
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5400-5407. doi:https://doi.org/10.1167/iovs.10-6178
Rewiring Integrin-Mediated Signaling and Cellular Response with the Peripheral Myelin Protein 22 and Epithelial Membrane Protein 2 Components of the Tetraspan Web Free
PDF
Shawn A. Morales; David Telander; Lucia Notterpek; Madhuri Wadehra; Jonathan Braun; Lynn K. Gordon
Tags: collagen, gel, integrins, pmp22 gene, signal transduction
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5465-5472. doi:https://doi.org/10.1167/iovs.10-6139
The Role of N-Methyl-D-Aspartate Receptor Activation in Homocysteine-Induced Death of Retinal Ganglion Cells Free
PDF
Preethi S. Ganapathy; Richard E. White; Yonju Ha; B. Renee Bozard; Paul L. McNeil; R. William Caldwell; Sanjiv Kumar; Stephen M. Black; Sylvia B. Smith
Tags: homocysteine, n-methylaspartate, n-methyl-d-aspartate receptors, retinal ganglion cells, ganglia
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5515-5524. doi:https://doi.org/10.1167/iovs.10-6870
Homocysteine-Mediated Modulation of Mitochondrial Dynamics in Retinal Ganglion Cells Free
PDF
Preethi S. Ganapathy; Richard L. Perry; Amany Tawfik; Robert M. Smith; Elizabeth Perry; Penny Roon; B. Renee Bozard; Yonju Ha; Sylvia B. Smith
Tags: homocysteine, mice, mitochondria, optic atrophy, autosomal dominant, retinal ganglion cells
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5551-5558. doi:https://doi.org/10.1167/iovs.11-7256
Transport via SLC5A8 (SMCT1) Is Obligatory for 2-Oxothiazolidine-4-Carboxylate to Enhance Glutathione Production in Retinal Pigment Epithelial Cells Free
PDF
Ellappan Babu; Sudha Ananth; Rajalakshmi Veeranan-Karmegam; Veena Coothankandaswamy; Sylvia B. Smith; Thomas Boettger; Vadivel Ganapathy; Pamela M. Martin
Tags: biological transport, drugs, non-prescription, glutathione, retinal pigment cell, oocytes
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5749-5757. doi:https://doi.org/10.1167/iovs.10-6825
Normoxic Activation of Hypoxia-Inducible Factors in Photoreceptors Provides Transient Protection against Light-Induced Retinal Degeneration Free
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Christina Lange; Severin R. Heynen; Naoyuki Tanimoto; Markus Thiersch; Yun-Zheng Le; Isabelle Meneau; Mathias W. Seeliger; Marijana Samardzija; Christian Caprara; Christian Grimm
Tags: hypoxia, mice, opsin, photoreceptors, retinal degeneration
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5872-5880. doi:https://doi.org/10.1167/iovs.11-7204
Altered Expression of the Transcription Factor Mef2c during Retinal Degeneration in Rpe65 –/– Mice Free
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Pascal Escher; Daniel F. Schorderet; Sandra Cottet
Tags: mice, retinal degeneration, transcription factor, retina, proteins
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5933-5940. doi:https://doi.org/10.1167/iovs.10-6978
Characterization of Conditioned Media Collected from Aged versus Young Human Eye Cups Free
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Anton M. Kolomeyer; Ilene K. Sugino; Marco A. Zarbin
Tags: adult, culture media, conditioned, eye, suidae, fetus
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5963-5972. doi:https://doi.org/10.1167/iovs.10-6440
Characterization of Conditioned Media Collected from Cultured Adult versus Fetal Retinal Pigment Epithelial Cells Free
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Anton M. Kolomeyer; Ilene K. Sugino; Marco A. Zarbin
Tags: adult, culture media, conditioned, fetus, retina, retinal pigment cell
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5973-5986. doi:https://doi.org/10.1167/iovs.10-6965
MCP-1–Activated Monocytes Induce Apoptosis in Human Retinal Pigment Epithelium Free
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Dongli Yang; Susan G. Elner; Xun Chen; Matthew G. Field; Howard R. Petty; Victor M. Elner
Tags: apoptosis, monocyte chemoattractant protein-1, monocytes, retinal pigment cell, retinal pigment epithelium
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6026-6034. doi:https://doi.org/10.1167/iovs.10-7023

Visual Psychophysics and Physiological Optics

Binocular Visual Simulation of a Corneal Inlay to Increase Depth of Focus Free
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Juan Tabernero; Christina Schwarz; Enrique J. Fernández; Pablo Artal
Tags: cornea, eye, optics, pupil, simulators
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5273-5277. doi:https://doi.org/10.1167/iovs.10-6436
Reproducibility of Measuring Lamina Cribrosa Pore Geometry in Human and Nonhuman Primates with In Vivo Adaptive Optics Imaging Free
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Kevin M. Ivers; Chaohong Li; Nimesh Patel; Nripun Sredar; Xunda Luo; Hope Queener; Ronald S. Harwerth; Jason Porter
Tags: cribriform plate, diagnostic imaging, eye, optics, primates
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5473-5480. doi:https://doi.org/10.1167/iovs.11-7347
Imaging of Forward Light-Scatter by Opacified Posterior Capsules Isolated from Pseudophakic Donor Eyes Free
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Maartje C. J. van Bree; Ivanka J. E. van der Meulen; Luuk Franssen; Joris E. Coppens; Nicolaas J. Reus; Bart L. M. Zijlmans; Thomas J. T. P. van den Berg
Tags: diagnostic imaging, donors, eye, goniometers, fibrosis
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5587-5597. doi:https://doi.org/10.1167/iovs.10-7073
Reading Pixelized Paragraphs of Chinese Characters Using Simulated Prosthetic Vision Free
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Ying Zhao; Yanyu Lu; Ji Zhao; Kaihu Wang; Qiushi Ren; Kaijie Wu; Xinyu Chai
Tags: chief complaint, chinese (other dialects), luminance, personality character, pixel
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5987-5994. doi:https://doi.org/10.1167/iovs.10-5293

Clinical Trials

Combining Structural and Functional Measurements to Improve Detection of Glaucoma Progression using Bayesian Hierarchical Models Free
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Felipe A. Medeiros; Mauro T. Leite; Linda M. Zangwill; Robert N. Weinreb
Tags: eye, functional measures, glaucoma, scanning laser polarimetry
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5794-5803. doi:https://doi.org/10.1167/iovs.10-7111
Early Perfusion of a Free RPE–Choroid Graft in Patients with Exudative Macular Degeneration Can Be Imaged with Spectral Domain–OCT Free
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Elsbeth J. T. van Zeeburg; Matteo G. Cereda; Josine van der Schoot; Grazia Pertile; Jan C. van Meurs
Tags: choroid, perfusion, surgical procedures, operative, tissue transplants, exudative age-related macular degeneration
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5881-5886. doi:https://doi.org/10.1167/iovs.11-7245
Spatial Resolution and Perception of Patterns Mediated by a Subretinal 16-Electrode Array in Patients Blinded by Hereditary Retinal Dystrophies Free
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Robert Wilke; Veit-Peter Gabel; Helmut Sachs; Karl-Ulrich Bartz Schmidt; Florian Gekeler; Dorothea Besch; Peter Szurman; Alfred Stett; Barbara Wilhelm; Tobias Peters; Alex Harscher; Udo Greppmaier; Steffen Kibbel; Heval Benav; Anna Bruckmann; Katarina Stingl; Akos Kusnyerik; Eberhart Zrenner
Tags: hereditary retinal dystrophy, implants, perception, accommodation phosphene, implantation procedure
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5995-6003. doi:https://doi.org/10.1167/iovs.10-6946
Role of Adenosine in the Control of Choroidal Blood Flow during Changes in Ocular Perfusion Pressure Free
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Doreen Schmidl; Guenther Weigert; Guido T. Dorner; Hemma Resch; Julia Kolodjaschna; Michael Wolzt; Gerhard Garhofer; Leopold Schmetterer
Tags: adenosine, perfusion, vascular flow, suction drainage, placebos
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6035-6039. doi:https://doi.org/10.1167/iovs.11-7491

New Developments in Vision Research

Müller Glia: A Promising Target for Therapeutic Regeneration Free
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Iqbal Ahmad; Carolina B. Del Debbio; Ani V. Das; Sowmya Parameswaran
Tags: neuroglia
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5758-5764. doi:https://doi.org/10.1167/iovs.11-7308

Research Opportunities

Current Prospects in Optic Nerve Protection and Regeneration: Sixth ARVO/Pfizer Ophthalmics Research Institute Conference Free
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G. Astrid Limb; Keith R. Martin; the Sixth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group
Tags: glaucoma, optic nerve, retina, brain-derived neurotrophic factor, axon
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5941-5954. doi:https://doi.org/10.1167/iovs.10-6894

Letters to the Editor

Ciliary Muscle Morphologic Changes with Accommodation and Axial Ametropia Free
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Joshua Ben-nun
Tags: ciliary muscle, refractive errors, visual accommodation
Investigative Ophthalmology & Visual Science July 2011, Vol.52, 5904. doi:https://doi.org/10.1167/iovs.11-7335

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science July 2011, Vol.52, 6057. doi:https://doi.org/10.1167/iovs.09-3674a
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