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Research Highlight

New Tool for Retinal Degeneration Research Free
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Henry Klassen
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 926. doi:https://doi.org/10.1167/iovs.12-9663

Anatomy and Pathology/Oncology

Involvement of SPARC and MMP-3 in the Pathogenesis of Human Pterygium Free
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Li-Fong Seet; Louis Tong; Roseline Su; Tina T. Wong
Tags: pterygium, sparc study, stromelysin 1, pathogenesis, conjunctiva
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 587-595. doi:https://doi.org/10.1167/iovs.11-7941
Retinoblastoma Treatment: Utilization of the Glycolytic Inhibitor, 2-deoxy-2-fluoro-d-glucose (2-FG), to Target the Chemoresistant Hypoxic Regions in LHBETATAG Retinal Tumors Free
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Yolanda Piña; Christina Decatur; Timothy G. Murray; Samuel K. Houston; Milena Lopez-Cavalcante; Eleut Hernandez; Magda Celdran; Nikesh Shah; William Feuer; Theodore Lampidis
Tags: glucose, hypoxia, neoplasms, retinal neoplasms, retinoblastoma
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 996-1002. doi:https://doi.org/10.1167/iovs.11-8265

Biochemistry and Molecular Biology

Slug Is Upregulated during Wound Healing and Regulates Cellular Phenotypes in Corneal Epithelial Cells Free
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Keiichi Aomatsu; Tokuzo Arao; Kosuke Abe; Aya Kodama; Koji Sugioka; Kazuko Matsumoto; Kanae Kudo; Hideharu Kimura; Yoshihiko Fujita; Hidetoshi Hayashi; Tomoyuki Nagai; Yoshikazu Shimomura; Kazuto Nishio
Tags: corneal epithelial cells, slugs, snails, wound healing, protein overexpression
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 751-756. doi:https://doi.org/10.1167/iovs.11-8222
Spliceosome Protein (SRp) Regulation of Glucocorticoid Receptor Isoforms and Glucocorticoid Response in Human Trabecular Meshwork Cells Free
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Ankur Jain; Robert J. Wordinger; Thomas Yorio; Abbot F. Clark
Tags: bombesin, glucocorticoid receptors, glucocorticoids, protein isoforms, proteins
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 857-866. doi:https://doi.org/10.1167/iovs.11-8497

Clinical and Epidemiologic Research

The Impact of Diabetic Retinopathy and Diabetic Macular Edema on Health-Related Quality of Life in Type 1 and Type 2 Diabetes Free
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Eva K. Fenwick; Jing Xie; Julie Ratcliffe; Konrad Pesudovs; Robert P. Finger; Tien Y. Wong; Ecosse L. Lamoureux
Tags: diabetes mellitus, type 2, diabetic macular edema, diabetic retinopathy, health-related quality of life, visual impairment
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 677-684. doi:https://doi.org/10.1167/iovs.11-8992
The Association between Glaucoma Prevalence and Supplementation with the Oxidants Calcium and Iron Free
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Sophia Y. Wang; Kuldev Singh; Shan C. Lin
Tags: calcium, glaucoma, iron, oxidants, prevalence
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 725-731. doi:https://doi.org/10.1167/iovs.11-9038

Cornea

Imaging and Evaluation of Corneal Vascularization Using Fluorescein and Indocyanine Green Angiography Free
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Deepa R. Anijeet; Yalin Zheng; Adrian Tey; Martin Hodson; Henri Sueke; Stephen B. Kaye
Tags: choroidal neovascularization, color, copy number polymorphism, corneal neovascularization, diagnostic imaging
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 650-658. doi:https://doi.org/10.1167/iovs.11-8014
Vascular Endothelial Growth Factor Receptor 1 Morpholino Decreases Angiogenesis in a Murine Corneal Suture Model Free
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Yang Kyung Cho; Hironori Uehara; Jason R. Young; Bonnie Archer; Xiaohui Zhang; Balamurali K. Ambati
Tags: angiogenesis, cornea, neovascularization, pathologic, sutures, vegfr-1
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 685-692. doi:https://doi.org/10.1167/iovs.11-8391
Cyclosporine Immunomodulation Retards Regeneration of Surgically Transected Corneal Nerves Free
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Abed Namavari; Shweta Chaudhary; Jin-Hong Chang; Lisette Yco; Snehal Sonawane; Vishakha Khanolkar; Beatrice Y. Yue; Joy Sarkar; Sandeep Jain
Tags: cornea, cyclosporine, immunomodulation, neurons, surgical procedures, operative
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 732-740. doi:https://doi.org/10.1167/iovs.11-8445
Variable Expression of Human beta Defensins 3 and 9 at the Human Ocular Surface in Infectious Keratitis Free
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Ahmad Muneer Otri; Imran Mohammed; Mouhamed A. Al-Aqaba; Usama Fares; Chen Peng; Andrew Hopkinson; Harminder S. Dua
Tags: beta-defensins, gene expression, infections, keratitis, rna
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 757-761. doi:https://doi.org/10.1167/iovs.11-8467
Optimization Model for UV-Riboflavin Corneal Cross-linking Free
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Silvia Schumacher; Michael Mrochen; Jeremy Wernli; Michael Bueeler; Theo Seiler
Tags: cornea, corneal collagen cross-linking, mass or substance concentration per volume, riboflavin, ultraviolet rays
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 762-769. doi:https://doi.org/10.1167/iovs.11-8059
Myofibroblast Differentiation Modulates Keratocyte Crystallin Protein Expression, Concentration, and Cellular Light Scattering Free
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James V. Jester; Donald Brown; Aglaia Pappa; Vasilis Vasiliou
Tags: crystallins, keratocytes, mass or substance concentration per volume, myofibroblasts, proteins
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 770-778. doi:https://doi.org/10.1167/iovs.11-9092
Amniotic Membrane Induces Peroxisome Proliferator-Activated Receptor-γ Positive Alternatively Activated Macrophages Free
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Dirk Bauer; Maren Hennig; Susanne Wasmuth; Hanna Baehler; Martin Busch; Klaus-Peter Steuhl; Solon Thanos; Arnd Heiligenhaus
Tags: amnion, cornea, macrophages
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 799-810. doi:https://doi.org/10.1167/iovs.11-7617
Substratum Topography Modulates Corneal Fibroblast to Myofibroblast Transformation Free
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Kathern E. Myrna; Rima Mendonsa; Paul Russell; Simon A. Pot; Sara J. Liliensiek; James V. Jester; Paul F. Nealey; Donald Brown; Christopher J. Murphy
Tags: cornea, cues, fibroblasts, myofibroblasts, phenotype
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 811-816. doi:https://doi.org/10.1167/iovs.11-7982
Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation Free
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Hiroki Ueno; Giulio Ferrari; Takaaki Hattori; Daniel R. Saban; Kishore R. Katikireddy; Sunil K. Chauhan; Reza Dana
Tags: cornea, nerve supply, stem cells, immunohistochemistry
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 867-872. doi:https://doi.org/10.1167/iovs.11-8438
Depth-Dependent Transverse Shear Properties of the Human Corneal Stroma Free
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Steven J. Petsche; Dimitri Chernyak; Jaime Martiz; Marc E. Levenston; Peter M. Pinsky
Tags: cornea, corneal stroma, stress, donors, body tissue
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 873-880. doi:https://doi.org/10.1167/iovs.11-8611
Progression of Keratoconus by Longitudinal Assessment with Corneal Topography Free
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Jin A Choi; Man-Soo Kim
Tags: astigmatism, cornea, corneal topography, keratoconus, eye
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 927-935. doi:https://doi.org/10.1167/iovs.11-8118
EphA2/Ephrin-A1 Signaling Complexes Restrict Corneal Epithelial Cell Migration Free
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Nihal Kaplan; Anees Fatima; Han Peng; Paul J. Bryar; Robert M. Lavker; Spiro Getsios
Tags: corneal epithelial cells, ephrins, ligands, signal transduction, complex
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 936-945. doi:https://doi.org/10.1167/iovs.11-8685
Role of CTCF in EGF-Induced Migration of Immortalized Human Corneal Epithelial Cells Free
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Ling Wang; Sophie X. Deng; Luo Lu
Tags: cell motility, corneal epithelial cells, wound healing, growth factor, rna, messenger
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 946-951. doi:https://doi.org/10.1167/iovs.11-8747
Biomechanics of the Anterior Human Corneal Tissue Investigated with Atomic Force Microscopy Free
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Marco Lombardo; Giuseppe Lombardo; Giovanni Carbone; Maria P. De Santo; Riccardo Barberi; Sebastiano Serrao
Tags: biomechanics, body tissue, cornea, microscopy, atomic force, hysteresis
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1050-1057. doi:https://doi.org/10.1167/iovs.11-8720

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

An Exploratory Study: Prolonged Periods of Binocular Stimulation Can Provide an Effective Treatment for Childhood Amblyopia Free
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Pamela J. Knox; Anita J. Simmers; Lyle S. Gray; Marie Cleary
Tags: amblyopia, amblyopia, pediatric, treatment effectiveness, training, eye
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 817-824. doi:https://doi.org/10.1167/iovs.11-8219

Genetics

Interactive Effects of ATOH7 and RFTN1 in Association with Adult-Onset Primary Open-Angle Glaucoma Free
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Jian-Huan Chen; Degui Wang; Chukai Huang; Yuqian Zheng; Haoyu Chen; Chi-Pui Pang; Mingzhi Zhang
Tags: open-angle glaucoma, adult
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 779-785. doi:https://doi.org/10.1167/iovs.11-8277

Glaucoma

Progressive Loss of Retinal Ganglion Cell Function Is Hindered with IOP-Lowering Treatment in Early Glaucoma Free
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Lori M. Ventura; William J. Feuer; Vittorio Porciatti
Tags: did not receive therapy or drug, eye, glaucoma, intraocular pressure, retinal ganglion cells
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 659-663. doi:https://doi.org/10.1167/iovs.11-8525
Dynamic Changes in Anterior Segment (AS) Parameters in Eyes with Primary Angle Closure (PAC) and PAC Glaucoma and Open-Angle Eyes Assessed Using AS Optical Coherence Tomography Free
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Youngrok Lee; Kyung Rim Sung; Jung Hwa Na; Jae Hong Sun
Tags: eye, glaucoma, optical coherence tomography, pupil, immune reconstitution inflammatory syndrome
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 693-697. doi:https://doi.org/10.1167/iovs.11-8389
Circadian (24-hour) Pattern of Intraocular Pressure and Visual Field Damage in Eyes with Normal-Tension Glaucoma Free
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Young Rok Lee; Michael S. Kook; Soo Geun Joe; Jung Hwa Na; Seungbong Han; Seonok Kim; Cheol Jin Shin
Tags: eye, intraocular pressure, low tension glaucoma, night time, visual fields
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 881-887. doi:https://doi.org/10.1167/iovs.11-7846
Substratum Stiffness and Latrunculin B Regulate Matrix Gene and Protein Expression in Human Trabecular Meshwork Cells Free
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Sara M. Thomasy; Joshua A. Wood; Philip H. Kass; Christopher J. Murphy; Paul Russell
Tags: genes, hydrogels, myoc gene, proteins, sparc study
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 952-958. doi:https://doi.org/10.1167/iovs.11-8526
Long-Term Rescue of Rat Retinal Ganglion Cells and Visual Function by AAV-Mediated BDNF Expression after Acute Elevation of Intraocular Pressure Free
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Ruotong Ren; Ying Li; Zhiping Liu; Kegao Liu; Shigang He
Tags: brain-derived neurotrophic factor, intraocular pressure, vision, retinal ganglion cells
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1003-1011. doi:https://doi.org/10.1167/iovs.11-8484
Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma Free
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Harsha L. Rao; Tukaram Kumbar; Uday K. Addepalli; Neha Bharti; Sirisha Senthil; Nikhil S. Choudhari; Chandra S. Garudadri
Tags: glaucoma, optical coherence tomography, optic disk, cohort studies, eye
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1058-1065. doi:https://doi.org/10.1167/iovs.11-8463

Immunology and Microbiology

Mesenchymal Stem Cells Induce Functionally Active T-Regulatory Lymphocytes in a Paracrine Fashion and Ameliorate Experimental Autoimmune Uveitis Free
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Roberta Tasso; Cristina Ilengo; Rodolfo Quarto; Ranieri Cancedda; Rachel R. Caspi; Giuseppina Pennesi
Tags: antigens, antigens, cd25, autoimmune diseases, autoimmunity, foxp3 gene
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 786-793. doi:https://doi.org/10.1167/iovs.11-8211
Aqueous Humor Suppression of Dendritic Cell Function Helps Maintain Immune Regulation in the Eye during Human Uveitis Free
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Alastair K. Denniston; Paul Tomlins; Geraint P. Williams; Sherine Kottoor; Imran Khan; Kadambari Oswal; Mike Salmon; Graham R. Wallace; Saaeha Rauz; Philip I. Murray; S. John Curnow
Tags: uveitis, eye, dendritic cells, aqueous humor
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 888-896. doi:https://doi.org/10.1167/iovs.11-8802
Characterization of Autoreactive and Bystander IL-17+ T Cells Induced in Immunized C57BL/6 Mice Free
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Hong Nian; Dongchun Liang; Aijun Zuo; Ruihua Wei; Hui Shao; Willi K. Born; Henry J. Kaplan; Deming Sun
Tags: immunization, interleukin-17, mice, t-lymphocytes, mice, inbred c57bl
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 897-905. doi:https://doi.org/10.1167/iovs.11-8297
Myeloid Suppressor Cells Induced by Retinal Pigment Epithelial Cells Inhibit Autoreactive T-Cell Responses That Lead to Experimental Autoimmune Uveitis Free
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Zhidan Tu; Yan Li; Dawn Smith; Catherine Doller; Sunao Sugita; Chi-Chao Chan; Shiguang Qian; John Fung; Rachel R. Caspi; Lina Lu; Feng Lin
Tags: autoimmune diseases, retinal pigment cell, t-lymphocytes, uveitis, autoimmunity
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 959-966. doi:https://doi.org/10.1167/iovs.11-8377
Increased IL-7 Expression in Vogt-Koyanagi-Harada Disease Free
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Yan Yang; Xiang Xiao; Fuzhen Li; Liping Du; Aize Kijlstra; Peizeng Yang
Tags: interleukin-7, uveomeningoencephalitic syndrome, t-lymphocytes, interleukin-17, cytokine
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1012-1017. doi:https://doi.org/10.1167/iovs.11-8505

Lens

Crystalline Lens Power and Refractive Error Free
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Rafael Iribarren; Ian G. Morgan; Vinay Nangia; Jost B. Jonas
Tags: cataract, lens, crystalline, refractive errors, refractive power, eye
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 543-550. doi:https://doi.org/10.1167/iovs.11-8523
A Role for Epha2 in Cell Migration and Refractive Organization of the Ocular Lens Free
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Yanrong Shi; Alicia De Maria; Thomas Bennett; Alan Shiels; Steven Bassnett
Tags: lens (device), lens, crystalline, sutures
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 551-559. doi:https://doi.org/10.1167/iovs.11-8568

Multidisciplinary Ophthalmic Imaging

Magnetic Resonance Imaging Indicates Decreased Choroidal and Retinal Blood Flow in the DBA/2J Mouse Model of Glaucoma Free
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William J. Lavery; Eric R. Muir; Jeffrey W. Kiel; Timothy Q. Duong
Tags: glaucoma, magnetic resonance imaging, mice, vascular flow, mice, inbred c57bl
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 560-564. doi:https://doi.org/10.1167/iovs.11-8429
Diffusion Tensor Imaging Correlates of Visual Impairment in Multiple Sclerosis and Chronic Optic Neuritis Free
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Scott C. Kolbe; Mark Marriott; Anneke van der Walt; Joanne Fielding; Alexander Klistorner; Peter J. Mitchell; Helmut Butzkueven; Trevor J. Kilpatrick; Gary F. Egan
Tags: diffusion tensor imaging, eye, multiple sclerosis, optic nerve, optic neuritis
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 825-832. doi:https://doi.org/10.1167/iovs.11-8864
Optimization of In Vivo Confocal Autofluorescence Imaging of the Ocular Fundus in Mice and Its Application to Models of Human Retinal Degeneration Free
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Peter Charbel Issa; Mandeep S. Singh; Daniel M. Lipinski; Ngaihang V. Chong; François C. Delori; Alun R. Barnard; Robert E. MacLaren
Tags: autofluorescence, diagnostic imaging, mice, retinal degeneration
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1066-1075. doi:https://doi.org/10.1167/iovs.11-8767

Physiology and Pharmacology

Sildenafil Accelerates Anterior Chamber Refilling after Paracentesis in Sheep and Rabbits Free
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Rosana Gerometta; Lawrence J. Alvarez; Oscar A. Candia
Tags: hypertension, intraocular pressure, oryctolagus cuniculus, paracentesis, sheep
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 565-573. doi:https://doi.org/10.1167/iovs.11-8275
Four Subunits (αβγδ) of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations Free
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Bettina Krueger; Ursula Schlötzer-Schrehardt; Silke Haerteis; Matthias Zenkel; Verena E. Chankiewitz; Kerstin U. Amann; Friedrich E. Kruse; Christoph Korbmacher
Tags: epithelial sodium channel, eye
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 596-604. doi:https://doi.org/10.1167/iovs.11-8581
Retinal Blood Flow in Healthy Young Subjects Free
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Gerhard Garhofer; Rene Werkmeister; Nikolaus Dragostinoff; Leopold Schmetterer
Tags: vascular flow
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 698-703. doi:https://doi.org/10.1167/iovs.11-8624

Retina

Retinal Function and Structure in the Hypotransferrinemic Mouse Free
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Michal Lederman; Alexey Obolensky; Michelle Grunin; Eyal Banin; Itay Chowers
Tags: iron, mice, proteins, retina, rna, messenger
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 605-612. doi:https://doi.org/10.1167/iovs.11-7436
The Cross-linked Biopolymer Hyaluronic Acid as an Artificial Vitreous Substitute Free
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Charlotte Schramm; Martin S. Spitzer; Sigrid Henke-Fahle; Gabriele Steinmetz; Kai Januschowski; Peter Heiduschka; Jürgen Geis-Gerstorfer; Tilo Biedermann; Karl U. Bartz-Schmidt; Peter Szurman
Tags: biopolymers, hyaluronic acid, hydrogels, vitreous substitute, biocompatibility
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 613-621. doi:https://doi.org/10.1167/iovs.11-7322
Natural History of Age-Related Retinal Lesions That Precede AMD in Mice Fed High or Low Glycemic Index Diets Free
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Karen A. Weikel; Paul FitzGerald; Fu Shang; M. Andrea Caceres; Qingning Bian; James T. Handa; Alan W. Stitt; Allen Taylor
Tags: diet, mice
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 622-632. doi:https://doi.org/10.1167/iovs.11-8545
Differential Gene Expression in Eyecup and Retina of a Mouse Model of Stargardt-like Macular Dystrophy (STGD3) Free
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Sharee Kuny; Frédéric Gaillard; Yves Sauvé
Tags: gene expression, macular dystrophy, mice, proteins, retina
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 664-675. doi:https://doi.org/10.1167/iovs.11-8418
Blue Flash ERG PhNR Changes Associated with Poor Long-Term Glycemic Control in Adolescents with Type 1 Diabetes Free
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Michelle McFarlane; Tom Wright; Derek Stephens; Josefin Nilsson; Carol A. Westall
Tags: adolescent, diabetes mellitus, type 1, electroretinography, glycemic control, hemoglobin a, glycosylated
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 741-748. doi:https://doi.org/10.1167/iovs.11-8263
Significance of C2/CFB Variants in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Japanese Population Free
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Isao Nakata; Kenji Yamashiro; Ryo Yamada; Norimoto Gotoh; Hideo Nakanishi; Hisako Hayashi; Yumiko Akagi-Kurashige; Akitaka Tsujikawa; Atsushi Otani; Masaaki Saito; Tomohiro Iida; Akio Oishi; Keitaro Matsuo; Kazuo Tajima; Fumihiko Matsuda; Nagahisa Yoshimura
Tags: age-related macular degeneration, japanese, vascular diseases, cohort studies, cataract
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 794-798. doi:https://doi.org/10.1167/iovs.11-8468
Relationships among Multifocal Electroretinogram Amplitude, Visual Field Sensitivity, and SD-OCT Receptor Layer Thicknesses in Patients with Retinitis Pigmentosa Free
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Yuquan Wen; Martin Klein; Donald C. Hood; David G. Birch
Tags: electroretinography, retinitis pigmentosa, visual fields
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 833-840. doi:https://doi.org/10.1167/iovs.11-8410
Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4-Associated Retinopathy Trials Free
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Artur V. Cideciyan; Malgorzata Swider; Tomas S. Aleman; Willam J. Feuer; Sharon B. Schwartz; Robert C. Russell; Janet D. Steinberg; Edwin M. Stone; Samuel G. Jacobson
Tags: macular degeneration, macular function, outcome measures, perimetry, retina
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 841-852. doi:https://doi.org/10.1167/iovs.11-8415
Physiological and Toxicological Effects of Cefuroxime on the Albino Rabbit Retina Free
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Jonathan Shahar; Esther Zemel; Ido Perlman; Anat Loewenstein
Tags: cefuroxime, electroretinography, erg protein, human, oryctolagus cuniculus, retina
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 906-914. doi:https://doi.org/10.1167/iovs.11-8053
Meckelin Is Necessary for Photoreceptor Intraciliary Transport and Outer Segment Morphogenesis Free
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Gayle B. Collin; Jungyeon Won; Wanda L. Hicks; Susan A. Cook; Patsy M. Nishina; Jürgen K. Naggert
Tags: biological transport, mice, morphogenesis, photoreceptors, proteins
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 967-974. doi:https://doi.org/10.1167/iovs.11-8766
Topographic Variation and Interocular Symmetry of Macular Choroidal Thickness Using Enhanced Depth Imaging Optical Coherence Tomography Free
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Fred K. Chen; Jonathan Yeoh; Waheeda Rahman; Praveen J. Patel; Adnan Tufail; Lyndon Da Cruz
Tags: axl gene, diagnostic imaging, eye, optical coherence tomography
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 975-985. doi:https://doi.org/10.1167/iovs.11-8771
Long-Term Effects of Intravitreal Injection of GMP-Grade Bone-Marrow–Derived CD34+ Cells in NOD-SCID Mice with Acute Ischemia-Reperfusion Injury Free
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Susanna S. Park; Sergio Caballero; Gerhard Bauer; Bradley Shibata; Alan Roth; Paul G. Fitzgerald; Krisztina I. Forward; Ping Zhou; Jeannine McGee; David G. Telander; Maria B. Grant; Jan A. Nolta
Tags: cd34 antigens, eye, intravitreal injections, mice, reperfusion injury
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 986-994. doi:https://doi.org/10.1167/iovs.11-8833
Prevalence and Risk Factors of Epiretinal Membrane in Asian Indians Free
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Victor Koh; Carol Y. Cheung; Wan-Ling Wong; Chui-Min Cheung; Jie Jin Wang; Paul Mitchell; Christine Younan; Seang Mei Saw; Tien Y. Wong
Tags: asian indians, epiretinal membrane, prevalence, risk factors, cardiac mri
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1018-1022. doi:https://doi.org/10.1167/iovs.11-8557
Effect of Pigment Epithelium–Derived Factor on Glutamate Uptake in Retinal Müller Cells under High-Glucose Conditions Free
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Bing Xie; Qin Jiao; Yu Cheng; Yisheng Zhong; Xi Shen
Tags: glucose, glutamate, glutamates, pigment, oxidative stress
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1023-1032. doi:https://doi.org/10.1167/iovs.11-8695
High Prevalence of Mutations in the EYS Gene in Japanese Patients with Autosomal Recessive Retinitis Pigmentosa Free
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Masaki Iwanami; Mio Oshikawa; Tomomi Nishida; Satoshi Nakadomari; Seishi Kato
Tags: autosomal recessive inheritance, genes, japanese, mutation, retinitis pigmentosa
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1033-1040. doi:https://doi.org/10.1167/iovs.11-9048

Retinal Cell Biology

γ-Secretase Inhibition of Murine Choroidal Neovascularization Is Associated with Reduction of Superoxide and Proinflammatory Cytokines Free
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Xiaoping Qi; Jun Cai; Qing Ruan; Li Liu; Sanford L. Boye; Zhijuan Chen; William W. Hauswirth; Renee C. Ryals; Lynn Shaw; Sergio Caballero; Maria B. Grant; Michael E. Boulton
Tags: choroidal neovascularization, cytokine, lasers, protein overexpression, superoxides
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 574-585. doi:https://doi.org/10.1167/iovs.11-8728
Neuroglobin Protection in Retinal Ischemia Free
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Anita S.Y. Chan; Sindhu Saraswathy; Matus Rehak; Mari Ueki; Narsing A. Rao
Tags: ischemia, mice, mitochondria, reperfusion therapy, retina
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 704-711. doi:https://doi.org/10.1167/iovs.11-7408
Partial Rescue of Retinal Function in Chronically Hypoglycemic Mice Free
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Yumiko Umino; Nicolas Cuenca; Drew Everhart; Laura Fernandez-Sanchez; Robert B. Barlow; Eduardo Solessio
Tags: diet, gcgr gene, glucagon receptors, hypoglycemic agents, mice
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 915-923. doi:https://doi.org/10.1167/iovs.11-8787
Effects of Antioxidant Components of AREDS Vitamins and Zinc Ions on Endothelial Cell Activation: Implications for Macular Degeneration Free
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Shemin Zeng; Jasmine Hernández; Robert F. Mullins
Tags: endothelial cells, intercellular adhesion molecule 1, vitamins, zinc, ions
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1041-1047. doi:https://doi.org/10.1167/iovs.11-8531

Visual Psychophysics and Physiological Optics

Estimation of Spatial Scale across the Visual Field Using Sinusoidal Stimuli Free
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Kelsey M. Keltgen; William H. Swanson
Tags: contrast sensitivity, visual fields, nose, spatial frequency
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 633-639. doi:https://doi.org/10.1167/iovs.10-6674

Clinical Trials

A Randomized Trial Using Progressive Addition Lenses to Evaluate Theories of Myopia Progression in Children with a High Lag of Accommodation Free
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David A. Berntsen; Loraine T. Sinnott; Donald O. Mutti; Karla Zadnik
Tags: child, lens (device), lens, crystalline, myopia, papillon-lefevre disease
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 640-649. doi:https://doi.org/10.1167/iovs.11-7769

Review

Spontaneous Ocular and Neurologic Deficits in Transgenic Mouse Models of Multiple Sclerosis and Noninvasive Investigative Modalities: A Review Free
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Archana A. Gupta; Di Ding; Richard K. Lee; Robert B. Levy; Sanjoy K. Bhattacharya
Tags: diagnostic imaging, experimental autoimmune encephalomyelitis, magnetic resonance imaging, mice, mice, transgenic
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 712-724. doi:https://doi.org/10.1167/iovs.11-8351

Letters to the Editor

Author Response: Bayesian Estimation of Sensitivity of Temporal Artery Biopsies Free
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Ryan D. Niederkohr; Leonard A. Levin
Tags: temporal artery biopsy
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 586. doi:https://doi.org/10.1167/iovs.11-9361
Author Response: Does the Time of Inactivation of pRb Determine the Cell of Origin of Retinoblastoma? Free
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Timothy W. Corson; Sanja Pajovic; Helen Dimaras; Brigitte L. Thériault; Brenda L. Gallie
Tags: cells, retinoblastoma, retinoblastoma protein
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 676. doi:https://doi.org/10.1167/iovs.11-9371
Retinal Nerve Fiber Layer Thickness Measurements in Rats with Spectral Domain–Optical Coherence Tomography Free
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Jinhai Huang; Giacomo Savini; Yifan Feng; Qinmei Wang
Tags: optical coherence tomography, rats, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 749-750. doi:https://doi.org/10.1167/iovs.11-9416
Retinal Thickness Measurement Using OCT Free
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Sahar Parvizi; Nigel P. Davies
Tags: diabetic retinopathy, interval data, macular edema, cystoid, ranibizumab, retinal vascular disorders
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 853-854. doi:https://doi.org/10.1167/iovs.12-9445
Author Response: Retinal Thickness Measurement in OCT Free
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John F. Payne; Beau B. Bruce; Steven Yeh
Tags: age-related macular degeneration, balance, device, clinical trials, cohort studies, comprehension
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 854-855. doi:https://doi.org/10.1167/iovs.12-9527
Author Response: Predictors of Visual Acuity in Macular Edema Free
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Lucia Pelosini; Christopher C. Hull; James F. Boyce; Dominic McHugh; Miles R. Stanford; John Marshall
Tags: edema, visual acuity
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 924. doi:https://doi.org/10.1167/iovs.11-9278
Corneal Thinning Phenotypes—An Alternative Perspective Free
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Osama Giasin; Rehna S. Khan; Kamron Khan
Tags: cornea, phenotype
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1048. doi:https://doi.org/10.1167/iovs.11-9372
Author Response: Corneal Thinning Phenotypes—An Alternative Perspective Free
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Benjamin W. Iliff; S. Amer Riazuddin; John D. Gottsch
Tags: cornea, phenotype
Investigative Ophthalmology & Visual Science February 2012, Vol.53, 1048-1049. doi:https://doi.org/10.1167/iovs.12-9545

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science February 2012, Vol.53, 856. doi:https://doi.org/10.1167/iovs.09-4747a
Erratum Free
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Investigative Ophthalmology & Visual Science February 2012, Vol.53, 925. doi:https://doi.org/10.1167/iovs.10-7146a
Erratum Free
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Investigative Ophthalmology & Visual Science February 2012, Vol.53, 995. doi:https://doi.org/10.1167/iovs.11-8472a
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