Volume 53 Issue 3 | IOVS

Identification of RALDH2 as a Visually Regulated Retinoic Acid Synthesizing Enzyme in the Chick Choroid Free

Jody A. Summers Rada; Lindsey R. Hollaway; Wengtse Lam; Nan Li; Joseph L. Napoli

Tags: choroid, enzymes, tretinoin, eye, sclera

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1649-1662. doi:https://doi.org/10.1167/iovs.11-8444

Alterations in the Biomolecular Signatures of Developing Chick Corneas as Determined by Biospectroscopy and Multivariate Analysis Free

PDF

Weiyi Pang; Abdullah A. Ahmadzai; Imran I. Patel; Xiaoqiang Qiu; Melody Liles; Andrew J. Quantock; Francis L. Martin

Tags: cornea, spectroscopy, fourier transform infrared, spectrum analysis

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1162-1168. doi:https://doi.org/10.1167/iovs.11-9262

Signaling States of Rhodopsin in Rod Disk Membranes Lacking Transducin βγ-Complex Free

PDF

Elena Lomonosova; Alexander V. Kolesnikov; Vladimir J. Kefalov; Oleg G. Kisselev

Tags: rhodopsin, rod photoreceptors, tissue membrane, transducin, signal transduction

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1225-1233. doi:https://doi.org/10.1167/iovs.11-9350

Rpgr^ORF15 Connects to the Usher Protein Network through Direct Interactions with Multiple Whirlin Isoforms Free

PDF

Rachel N. Wright; Dong-Hyun Hong; Brian Perkins

Tags: protein isoforms, proteins, mice, photoreceptors, antibodies

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1519-1529. doi:https://doi.org/10.1167/iovs.11-8845

Clinical and Epidemiologic Research

Associations among Visual Acuity and Vision- and Health-Related Quality of Life among Patients in the Multicenter Uveitis Steroid Treatment Trial Free

PDF

Kevin D. Frick; Lea T. Drye; John H. Kempen; James P. Dunn; Gary N. Holland; Paul Latkany; Narsing A. Rao; H. Nida Sen; Elizabeth A. Sugar; Jennifer E. Thorne; Robert C. Wang; Janet T. Holbrook; for the Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group

Tags: uveitis, vision, visual acuity, steroid therapy, health

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1169-1176. doi:https://doi.org/10.1167/iovs.11-8259

Cultured Autologous Oral Mucosal Epithelial Cell Sheet (CAOMECS) Transplantation for the Treatment of Corneal Limbal Epithelial Stem Cell Deficiency Free

PDF

Carole Burillon; Laure Huot; Virginie Justin; Serge Nataf; François Chapuis; Evelyne Decullier; Odile Damour

Tags: cornea, epithelial cells, epithelial stem cells, oral mucous membrane, transplantation

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1325-1331. doi:https://doi.org/10.1167/iovs.11-7744

TSG-6 Controls Transcription and Activation of Matrix Metalloproteinase 1 in Conjunctivochalasis Free

PDF

Ping Guo; Su-Zhen Zhang; Hua He; Ying-Ting Zhu; Scheffer C. G. Tseng

Tags: conjunctivochalasis, fibroblasts, interstitial collagenase, proteins, stromelysin 1

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1372-1380. doi:https://doi.org/10.1167/iovs.11-8738

The Effect of Daily Transient +4 D Positive Lens Wear on the Inhibition of Myopia in the Tree Shrew Free

PDF

Neville A. McBrien; Baskar Arumugam; Sangeetha Metlapally

Tags: lens (device), lens, crystalline, myopia, tupaiidae

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1593-1601. doi:https://doi.org/10.1167/iovs.11-7859

Cornea

Growth Factor Regulation of Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices Free

PDF

Neema Lakshman; W. Matthew Petroll

Tags: collagen, cornea, growth factor, keratocytes, phenotype

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1077-1086. doi:https://doi.org/10.1167/iovs.11-8609

Improved Corneal Wound Healing through Modulation of Gap Junction Communication Using Connexin43-Specific Antisense Oligodeoxynucleotides Free

PDF

Christina N. Grupcheva; Wilda T. Laux; Ilva D. Rupenthal; Jennifer McGhee; Charles N. J. McGhee; Colin R. Green

Tags: connexin 43, cornea, gap junction protein, oligodeoxyribonucleotides, antisense, wound healing

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1130-1138. doi:https://doi.org/10.1167/iovs.11-8711

Corneal and Conjunctival Sensory Function: The Impact on Ocular Surface Sensitivity of Change from Low to High Oxygen Transmissibility Contact Lenses Free

PDF

Blanka Golebiowski; Eric B. Papas; Fiona Stapleton

Tags: conjunctiva, contact lenses, cornea, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1177-1181. doi:https://doi.org/10.1167/iovs.11-8416

Changes in Corneal Innervation and Sensitivity and Acetylcholine-Mediated Vascular Relaxation of the Posterior Ciliary Artery in a Type 2 Diabetic Rat Free

PDF

Eric P. Davidson; Lawrence J. Coppey; Amey Holmes; Mark A. Yorek

Tags: acetylcholine, ciliary artery, cornea, diabetes mellitus, nerve supply

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1182-1187. doi:https://doi.org/10.1167/iovs.11-8806

Expression and Localization of Neural Cell Adhesion Molecule and Polysialic Acid during Chick Corneal Development Free

PDF

Xiuli Mao; Tyler Schwend; Gary W. Conrad

Tags: cornea, neural cell adhesion molecules

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1234-1243. doi:https://doi.org/10.1167/iovs.11-8834

Vascular Endothelial Growth Factor-C Promotes Alloimmunity by Amplifying Antigen-Presenting Cell Maturation and Lymphangiogenesis Free

PDF

Amir R. Hajrasouliha; Toshinari Funaki; Zahra Sadrai; Takaaki Hattori; Sunil K. Chauhan; Reza Dana

Tags: keratoplasty, vascular endothelial growth factor a, vascular endothelial growth factor c, alloimmunity, cornea

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1244-1250. doi:https://doi.org/10.1167/iovs.11-8668

Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure Free

PDF

Takenori Inomata; Nobuyuki Ebihara; Toshinari Funaki; Akira Matsuda; Yasuo Watanabe; Liang Ning; Zhuo Xu; Akira Murakami; Eri Arikawa-Hirasawa

Tags: cornea, corneal epithelium, epithelium, mice, mutation

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1277-1284. doi:https://doi.org/10.1167/iovs.11-8742

Netrin-1 Simultaneously Suppresses Corneal Inflammation and Neovascularization Free

PDF

Yun Han; Yi Shao; Zhirong Lin; Yang-Luowa Qu; He Wang; Yueping Zhou; Wensheng Chen; Yongxiong Chen; Wei-Li Chen; Fung-Rong Hu; Wei Li; Zuguo Liu

Tags: alkalies, burns, cornea, keratitis, neovascularization, pathologic

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1285-1295. doi:https://doi.org/10.1167/iovs.11-8722

Corneal Surface Asphericity, Roughness, and Transverse Contraction after Uniform Scanning Excimer Laser Ablation Free

PDF

Sean J. McCafferty; Jim T. Schwiegerling; Eniko T. Enikov

Tags: ablation, cornea, excimer lasers

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1296-1305. doi:https://doi.org/10.1167/iovs.11-9267

Optical Coherence Tomography as a Rapid, Accurate, Noncontact Method of Visualizing the Palisades of Vogt Free

PDF

Kira L. Lathrop; Divya Gupta; Larry Kagemann; Joel S. Schuman; Nirmala SundarRaj

Tags: cornea, diagnostic imaging, optical coherence tomography, reconstructive surgical procedures, body tissue

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1381-1387. doi:https://doi.org/10.1167/iovs.11-8524

Femtosecond Lenticule Extraction (FLEx): Clinical Results, Interface Evaluation, and Intraocular Pressure Variation Free

PDF

Marcus Ang; Shyam S. Chaurasia; Romesh I. Angunawela; Rebekah Poh; Andri Riau; Donald Tan; Jodhbir S. Mehta

Tags: eye, intraocular pressure, keratomileusis, laser in situ, surgical flaps, astigmatism

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1414-1421. doi:https://doi.org/10.1167/iovs.11-8808

The Diurnal Variation of Matrix Metalloproteinase-9 and Its Associated Factors in Human Tears Free

PDF

Maria Markoulli; Eric Papas; Nerida Cole; Brien A. Holden

Tags: circadian rhythms, gelatinase b, awakening, tissue-inhibitor of metalloproteinase-1

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1479-1484. doi:https://doi.org/10.1167/iovs.11-8365

Correlation of Tear Inflammatory Cytokines and Matrix Metalloproteinases with Four Dry Eye Diagnostic Tests Free

PDF

Karl R. VanDerMeid; Stephanie P. Su; Keith W. Ward; Jin-Zhong Zhang

Tags: cytokine, diagnostic techniques and procedures, dry eye syndromes, matrix metalloproteinases

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1512-1518. doi:https://doi.org/10.1167/iovs.11-7627

NF-κB Is the Transcription Factor for FGF-2 That Causes Endothelial Mesenchymal Transformation in Cornea Free

PDF

Jeong Goo Lee; EunDuck P. Kay

Tags: 1-phosphatidylinositol 3-kinase, cornea, endothelium, fibroblast growth factor 2, transcription factor

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1530-1538. doi:https://doi.org/10.1167/iovs.11-9102

Mitomycin C Retardation of Corneal Fibroblast Migration via Sustained Dephosphorylation of Paxillin at Tyrosine 118 Free

PDF

Tsan-Chi Chen; Chien-Hsueh Lai; Jie-Ling Chang; Shu-Wen Chang

Tags: cornea, diphtheria-tetanus-pertussis vaccine, fibroblasts, mitomycin, tyrosine

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1539-1547. doi:https://doi.org/10.1167/iovs.11-9203

Transplantation of Cultivated Oral Mucosal Epithelium Prepared in Fibrin-Coated Culture Dishes Free

PDF

Masatoshi Hirayama; Yoshiyuki Satake; Kazunari Higa; Takefumi Yamaguchi; Jun Shimazaki

Tags: cooking and eating utensils, epithelium, eye, fibrin, oral mucous membrane

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1602-1609. doi:https://doi.org/10.1167/iovs.11-7847

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography Free

PDF

Lisanne J. Balk; Judith M. Sonder; Eva M. M. Strijbis; Jos W. R. Twisk; Joep Killestein; Bernard M. J. Uitdehaag; Chris H. Polman; Axel Petzold

Tags: optical coherence tomography, retinal nerve fiber layer, volume

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1251-1257. doi:https://doi.org/10.1167/iovs.11-8209

Nintendo Wii Remote Controllers for Head Posture Measurement: Accuracy, Validity, and Reliability of the Infrared Optical Head Tracker Free

PDF

Jongshin Kim; Kyoung Won Nam; Ik Gyu Jang; Hee Kyung Yang; Kwang Gi Kim; Jeong-Min Hwang

Tags: optics, posture, reliability, validity of results

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1388-1396. doi:https://doi.org/10.1167/iovs.11-8329

Genetics

Relevance of Complement Factor H–Related 1 (CFHR1) Genotypes in Age-Related Macular Degeneration Free

PDF

Rubén Martínez-Barricarte; Sergio Recalde; Patricia Fernández-Robredo; Isabel Millán; Leticia Olavarrieta; Antonio Viñuela; Julián Pérez-Pérez; Alfredo García-Layana; Santiago Rodríguez de Córdoba; the Spanish Multicenter Group on AMD

Tags: age-related macular degeneration, complement factor h, genotype, alleles, genes

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1087-1094. doi:https://doi.org/10.1167/iovs.11-8709

A Genetic Epidemiologic Study of Candidate Genes Involved in the Optic Nerve Head Morphology Free

PDF

Andrea C. Gasten; Wishal D. Ramdas; Linda Broer; Leonieke M. E. van Koolwijk; M. Kamran Ikram; Paulus T. V. M. de Jong; Yurii S. Aulchenko; Roger C. Wolfs; Albert Hofman; Fernando Rivadeneira; Andre G. Uitterlinden; Ben A. Oostra; Hans G. Lemij; Caroline C. W. Klaver; Nomdo M. Jansonius; Johannes R. Vingerling; Cornelia M. van Duijn

Tags: candidate disease gene, cohort studies, epidemiologic studies, genetics, language morphology

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1485-1491. doi:https://doi.org/10.1167/iovs.11-7384

Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-Related Macular Degeneration Using Multistate Markov Models Free

PDF

Yi Yu; Robyn Reynolds; Bernard Rosner; Mark J. Daly; Johanna M. Seddon

Tags: age-related macular degeneration, drusen, genes, genetics, single nucleotide polymorphism

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1548-1556. doi:https://doi.org/10.1167/iovs.11-8657

An Allele of Microtubule-Associated Protein 1A (Mtap1a) Reduces Photoreceptor Degeneration in Tulp1 and Tub Mutant Mice Free

PDF

Dennis M. Maddox; Sakae Ikeda; Akihiro Ikeda; Weidong Zhang; Mark P. Krebs; Patsy M. Nishina; Jürgen K. Naggert

Tags: alleles, mice, photoreceptors, retinal degeneration, tissue degeneration

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1663-1669. doi:https://doi.org/10.1167/iovs.11-8871

Glaucoma

Asymmetry in Hemifield Macular Thickness as an Early Indicator of Glaucomatous Change Free

PDF

Tae Woong Um; Kyung Rim Sung; Gadi Wollstein; Sung-Cheol Yun; Jung Hwa Na; Joel S. Schuman

Tags: glaucoma

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1139-1144. doi:https://doi.org/10.1167/iovs.11-8373

The Posterior Location of the Dilator Muscle Induces Anterior Iris Bowing during Dilation, Even in the Absence of Pupillary Block Free

PDF

Rouzbeh Amini; Julie E. Whitcomb; Muhammad K. Al-Qaisi; Taner Akkin; Sara Jouzdani; Syril Dorairaj; Tiago Prata; Elena Illitchev; Jeffrey M. Liebmann; Robert Ritch; Victor H. Barocas

Tags: dilatation, pathologic, dilators, genu varum, immune reconstitution inflammatory syndrome, iris

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1188-1194. doi:https://doi.org/10.1167/iovs.11-8408

Planimetrically Determined Vertical Cup/Disc and Rim Width/Disc Diameter Ratios and Related Factors Free

PDF

Tae Tsutsumi; Atsuo Tomidokoro; Makoto Araie; Aiko Iwase; Hiroshi Sakai; Shoichi Sawaguchi

Tags: diameter, eye, glaucoma, intraocular pressure, japanese

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1332-1340. doi:https://doi.org/10.1167/iovs.11-8533

Effect of Corneal Stiffening on Goldmann Applanation Tonometry and Tono-Pen Measurements in Canine Eyes Free

PDF

Junhua Tang; Xueliang Pan; Paul A. Weber; Jun Liu

Tags: cornea, dog, domestic, eye, tonometry, goldmann applanation, tonopen tonometer

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1397-1405. doi:https://doi.org/10.1167/iovs.11-8516

Body Mass Index Has a Linear Relationship with Cerebrospinal Fluid Pressure Free

PDF

John P. Berdahl; David Fleischman; Jana Zaydlarova; Sandra Stinnett; R. Rand Allingham; Michael P. Fautsch

Tags: body mass index procedure, cerebrospinal fluid pressure

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1422-1427. doi:https://doi.org/10.1167/iovs.11-8220

Silencing of Fem1c^R3 Gene Expression in the DBA/2J Mouse Precedes Retinal Ganglion Cell Death and Is Associated with Histone Deacetylase Activity Free

PDF

Heather R. Pelzel; Cassandra L. Schlamp; Michael Waclawski; Malissa K. Shaw; Robert W. Nickells

Tags: gene expression, glaucoma, histone deacetylase, mice, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1428-1435. doi:https://doi.org/10.1167/iovs.11-8872

In Vitro Interactions between Peripheral Blood Lymphocytes and the Wong-Kilbourne Derivative of Chang Conjunctival Cells Free

PDF

Alexis Chassignol; Emmanuelle Brasnu; Christophe Baudouin; Luisa Riancho; Jean-Michel Warnet; Françoise Brignole-Baudouin

Tags: bronchioloalveolar carcinoma, coculture techniques, conjunctiva, epithelial cells, lymphocytes

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1492-1498. doi:https://doi.org/10.1167/iovs.11-7708

Spectral-Domain Optical Coherence Tomography ofβ-zone Peripapillary Atrophy: Influence of Myopiaand Glaucoma Free

PDF

Keiko Hayashi; Atsuo Tomidokoro; Kelvin Y. C. Lee; Shinsuke Konno; Hitomi Saito; Chihiro Mayama; Makoto Aihara; Aiko Iwase; Makoto Araie

Tags: atrophy, eye, glaucoma, open-angle glaucoma, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1499-1505. doi:https://doi.org/10.1167/iovs.11-8572

Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma Free

PDF

Gulab S. Zode; Kevin E. Bugge; Kabhilan Mohan; Sinisa D. Grozdanic; Joseph C. Peters; Demelza R. Koehn; Michael G. Anderson; Randy H. Kardon; Edwin M. Stone; Val C. Sheffield

Tags: mice, myoc gene, glaucoma, open-angle glaucoma, sodium

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1557-1565. doi:https://doi.org/10.1167/iovs.11-8837

Multipotent Stem Cells from Trabecular Meshwork Become Phagocytic TM Cells Free

PDF

Yiqin Du; Danny S. Roh; Mary M. Mann; Martha L. Funderburgh; James L. Funderburgh; Joel S. Schuman

Tags: aquaporin 1, multipotent stem cells, polymerase chain reaction, stem cells, trabecular meshwork

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1566-1575. doi:https://doi.org/10.1167/iovs.11-9134

Horizontal Central Ridge of the Lamina Cribrosa and Regional Differences in Laminar Insertion in Healthy Subjects Free

PDF

Sung Chul Park; Saman Kiumehr; Christopher C. Teng; Celso Tello; Jeffrey M. Liebmann; Robert Ritch

Tags: cribriform plate, eye, geographic difference, diagnostic imaging, nose

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1610-1616. doi:https://doi.org/10.1167/iovs.11-7577

Suppression of Type I Collagen Expression by miR-29b via PI3K, Akt, and Sp1 Pathway in Human Tenon's Fibroblasts Free

PDF

Ning Li; Juanlian Cui; Xuanchu Duan; Huihui Chen; Fang Fan

Tags: collagen type i, fibroblasts, micrornas, phosphoinositide 3-kinase, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1670-1678. doi:https://doi.org/10.1167/iovs.11-8670

Human Aqueous Humor Phosphatase Activity in Cataract and Glaucoma Free

PDF

Galina Latarya; Ahmad Mansour; Irena Epstein; Daniel Cotlear; Joseph Pikkel; Shmuel Levartovsky; Michael Yulish; Elie Beit-Yannai

Tags: aqueous humor, cataract, glaucoma, hypertension, phosphoric monoester hydrolases

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1679-1684. doi:https://doi.org/10.1167/iovs.11-9120

Immunology and Microbiology

Differentiation between Infectious and Noninfectious Ulcerative Keratitis by Raman Spectra of Human Teardrops: A Pilot Study Free

PDF

Ming-Tse Kuo; Chi-Chang Lin; Hsin-Yu Liu; Mei-Yu Yang; Hsien-Chang Chang

Tags: corneal ulcer, pilot projects

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1436-1444. doi:https://doi.org/10.1167/iovs.11-7923

Changes in Murine Hyalocytes Are Valuable Early Indicators of Ocular Disease Free

PDF

Nina N. Vagaja; Holly R. Chinnery; Nicolette Binz; Jelena M. Kezic; Elizabeth P. Rakoczy; Paul G. McMenamin

Tags: eye, eye diseases, ligands, mice, phenotype

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1445-1451. doi:https://doi.org/10.1167/iovs.11-8601

Lens

Establishing Levels of Indications for Cataract Surgery: Combining Clinical and Questionnaire Data into a Measure of Cataract Impact Free

PDF

Colm McAlinden; Marina Jonsson; Maria Kugelberg; Mats Lundström; Jyoti Khadka; Konrad Pesudovs

Tags: cataract, cataract surgery, questionnaires, rasch model, visual acuity

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1095-1101. doi:https://doi.org/10.1167/iovs.11-8102

Cysteamine Prevents the Development of Lens Opacity in a Rat Model of Selenite-Induced Cataract Free

PDF

Sang-Mok Lee; Eui Man Jeong; Jinho Jeong; Dong-Myung Shin; Hyun-Ju Lee; Hyo-Jun Kim; Jisun Lim; Jin-Haeng Lee; Sung-Yup Cho; Mee-Kum Kim; Won-Ryang Wee; Jin-Hak Lee; In-Gyu Kim

Tags: cataract, cysteamine, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1452-1459. doi:https://doi.org/10.1167/iovs.11-8636

iSyTE: Integrated Systems Tool for Eye Gene Discovery Free

PDF

Salil A. Lachke; Joshua W. K. Ho; Gregory V. Kryukov; Daniel J. O'Connell; Anton Aboukhalil; Martha L. Bulyk; Peter J. Park; Richard L. Maas

Tags: genes, lens (device), lens, crystalline, cataract, mice

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1617-1627. doi:https://doi.org/10.1167/iovs.11-8839

Multidisciplinary Ophthalmic Imaging

Repeatability and Reproducibility of Subfoveal Choroidal Thickness in Normal Eyes of Japanese Using Different SD-OCT Devices Free

PDF

Toshifumi Yamashita; Takehiro Yamashita; Makoto Shirasawa; Noboru Arimura; Hiroto Terasaki; Taiji Sakamoto

Tags: eye, japanese, choroid

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1102-1107. doi:https://doi.org/10.1167/iovs.11-8836

Relationship between the Foveal Avascular Zone and Foveal Pit Morphology Free

PDF

Adam M. Dubis; Benjamin R. Hansen; Robert F. Cooper; Joseph Beringer; Alfredo Dubra; Joseph Carroll

Tags: language morphology, morphology

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1628-1636. doi:https://doi.org/10.1167/iovs.11-8488

Physiology and Pharmacology

Antiangiogenic Activity of Aganirsen in Nonhuman Primate and Rodent Models of Retinal Neovascular Disease after Topical Administration Free

PDF

Frank Cloutier; Matthew Lawrence; Robin Goody; Stéphanie Lamoureux; Salman Al-Mahmood; Sylvie Colin; Antoine Ferry; Jean-Pascal Conduzorgues; Amel Hadri; Claus Cursiefen; Patricia Udaondo; Eric Viaud; Eric Thorin; Sylvain Chemtob

Tags: administration, topical, angiogenesis inhibitors, choroidal neovascularization, irs1 protein, human, neovascularization, pathologic

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1195-1203. doi:https://doi.org/10.1167/iovs.11-9064

Sustained Ocular Delivery of Ciprofloxacin Using Nanospheres and Conventional Contact Lens Materials Free

PDF

Rahul Garhwal; Sally F. Shady; Edward J. Ellis; Jeanne Y. Ellis; Charles D. Leahy; Stephen P. McCarthy; Kathryn S. Crawford; Peter Gaines

Tags: ciprofloxacin, lens (device), lens, crystalline, contact lenses, anti-bacterial agents

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1341-1352. doi:https://doi.org/10.1167/iovs.11-8215

Retina

Age-Related Changes in Venous Endothelial Phenotype at Human Retinal Artery–Vein Crossing Points Free

PDF

Paula K. Yu; Priscilla E. Z. Tan; William H. Morgan; Stephen J. Cringle; Ian L. McAllister; Dao-Yi Yu

Tags: central retinal artery, donors, endothelial cells, endothelium, eye

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1108-1116. doi:https://doi.org/10.1167/iovs.11-8865

Association of Macular Pigment Density with Plasma Omega-3 Fatty Acids: The PIMAVOSA Study Free

PDF

Marie-Noëlle Delyfer; Benjamin Buaud; Jean-François Korobelnik; Marie-Bénédicte Rougier; Wolfgang Schalch; Stephane Etheve; Carole Vaysse; Nicole Combe; Mélanie Le Goff; Ute E. K. Wolf-Schnurrbusch; Sebastian Wolf; Pascale Barberger-Gateau; Cécile Delcourt

Tags: omega-3 fatty acids, phospholipids, pigment, plasma, lutein

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1204-1210. doi:https://doi.org/10.1167/iovs.11-8721

Choroidal Changes Associated with Reticular Pseudodrusen Free

PDF

Giuseppe Querques; Lea Querques; Raimondo Forte; Nathalie Massamba; Florence Coscas; Eric H. Souied

Tags: choroid, diagnostic imaging, drusen, eye, fovea centralis

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1258-1263. doi:https://doi.org/10.1167/iovs.11-8907

Analysis of Progression of Reticular Pseudodrusen by Spectral Domain–Optical Coherence Tomography Free

PDF

Giuseppe Querques; Florence Canouï-Poitrine; Florence Coscas; Nathalie Massamba; Lea Querques; Gerard Mimoun; Francesco Bandello; Eric H. Souied

Tags: eye, follow-up, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1264-1270. doi:https://doi.org/10.1167/iovs.11-9063

GNAT1 Associated with Autosomal Recessive Congenital Stationary Night Blindness Free

PDF

Muhammad Asif Naeem; Venkata R. M. Chavali; Shahbaz Ali; Muhammad Iqbal; Saima Riazuddin; Shaheen N. Khan; Tayyab Husnain; Paul A. Sieving; Radha Ayyagari; Sheikh Riazuddin; J. Fielding Hejtmancik; S. Amer Riazuddin

Tags: autosomal recessive inheritance, night blindness, congenital stationary, genome

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1353-1361. doi:https://doi.org/10.1167/iovs.11-8026

Recovery of Axonal Transport after Partial Optic Nerve Damage Is Associated with Secondary Retinal Ganglion Cell Death In Vivo Free

PDF

Sylvia Prilloff; Petra Henrich-Noack; Bernhard A. Sabel

Tags: axonal transport, dyes, optic nerve, recovery of function, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1460-1466. doi:https://doi.org/10.1167/iovs.11-8306

Photoreceptor and Post-Photoreceptoral Contributions to Photopic ERG a-Wave in Rhodopsin P347L Transgenic Rabbits Free

PDF

Rika Hirota; Mineo Kondo; Shinji Ueno; Takao Sakai; Toshiyuki Koyasu; Hiroko Terasaki

Tags: electroretinography, erg protein, human, oryctolagus cuniculus, photoreceptors, rhodopsin

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1467-1472. doi:https://doi.org/10.1167/iovs.11-9006

Optical Coherence Tomographic Reflectivity of Photoreceptors beneath Cystoid Spaces in Diabetic Macular Edema Free

PDF

Tomoaki Murakami; Kazuaki Nishijima; Tadamichi Akagi; Akihito Uji; Takahiro Horii; Naoko Ueda-Arakawa; Yuki Muraoka; Nagahisa Yoshimura

Tags: diabetic macular edema, embryonic lethal mutation, optical coherence tomography, photoreceptors, syncope

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1506-1511. doi:https://doi.org/10.1167/iovs.11-9231

Automated Assessment of Drusen Using Three-Dimensional Spectral-Domain Optical Coherence Tomography Free

PDF

Daisuke Iwama; Masanori Hangai; Sotaro Ooto; Atsushi Sakamoto; Hideo Nakanishi; Takashi Fujimura; Amitha Domalpally; Ronald P. Danis; Nagahisa Yoshimura

Tags: drusen, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1576-1583. doi:https://doi.org/10.1167/iovs.11-8103

Targeting of Junctional Adhesion Molecule-C Inhibits Experimental Choroidal Neovascularization Free

PDF

Xu Hou; Dan Hu; Yu-sheng Wang; Zhong-shu Tang; Fan Zhang; Triantafyllos Chavakis; Yang Li; Xuri Li

Tags: choroidal neovascularization, adhesions, macrophages, molecule, retinal pigment cell

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1584-1591. doi:https://doi.org/10.1167/iovs.11-9005

A Novel Experimental Mouse Model of Retinal Detachment: Complete Functional and Histologic Recovery of the Retina Free

PDF

Rui Zeng; Ying Zhang; Fanjun Shi; Fansheng Kong

Tags: eye, mice, retina, retinal detachment, recovery of function

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1685-1695. doi:https://doi.org/10.1167/iovs.11-8241

Retinal Cell Biology

CNGA3 Deficiency Affects Cone Synaptic Terminal Structure and Function and Leads to Secondary Rod Dysfunction and Degeneration Free

PDF

Jianhua Xu; Lynsie M. Morris; Stylianos Michalakis; Martin Biel; Steven J. Fliesler; David M. Sherry; Xi-Qin Ding

Tags: mice, presynaptic terminals, retinal cone, rod photoreceptors, tissue degeneration

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1117-1129. doi:https://doi.org/10.1167/iovs.11-8168

Complement and UV-Irradiated Photoreceptor Outer Segments Increase the Cytokine Secretion by Retinal Pigment Epithelial Cells Free

PDF

Katharina Lueck; Maren Hennig; Albrecht Lommatzsch; Daniel Pauleikhoff; Susanne Wasmuth

Tags: bodily secretions, burkina faso, complement system proteins, cytokine, retinal pigment cell

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1406-1413. doi:https://doi.org/10.1167/iovs.11-8889

Thy1 Associates with the Cation Channel Subunit HCN4 in Adult Rat Retina Free

PDF

Gloria J. Partida; Tyler W. Stradleigh; Genki Ogata; Iv Godzdanker; Andrew T. Ishida

Tags: adult, antibodies, cations, hcn4 gene, proteins

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1696-1703. doi:https://doi.org/10.1167/iovs.11-9307

Visual Neuroscience

Visual Acuity Is Reduced in Αlpha 7 Nicotinic Receptor Knockout Mice Free

PDF

Nicola Origlia; Dario Riccardo Valenzano; Milena Moretti; Cecilia Gotti; Luciano Domenici

Tags: mice, mice, knockout, nicotinic receptors, visual acuity, evoked potentials, visual

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1211-1218. doi:https://doi.org/10.1167/iovs.11-8007

Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study Free

PDF

Prema Sriram; Stuart L. Graham; Chenyu Wang; Con Yiannikas; Raymond Garrick; Alexander Klistorner

Tags: glaucoma, optic nerve disorders, optical coherence tomography, retina, retinal degeneration

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1271-1275. doi:https://doi.org/10.1167/iovs.11-8732

Latency Measures of Pattern-Reversal VEP in Adults and Infants: Different Information from Transient P1 Response and Steady-State Phase Free

PDF

Jin Lee; Deirdre Birtles; John Wattam-Bell; Janette Atkinson; Oliver Braddick

Tags: adult, evoked potentials, visual, infant, steady state

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1306-1314. doi:https://doi.org/10.1167/iovs.11-7631

The Photopic Negative Response of the Flash Electroretinogram in Multiple Sclerosis Free

PDF

Jing Wang; Han Cheng; Ying-Sheng Hu; Rosa A. Tang; Laura J. Frishman

Tags: electroretinography, eye, multiple sclerosis, retinal nerve fiber layer, medical history

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1315-1323. doi:https://doi.org/10.1167/iovs.11-8461

Normalization of Visual Evoked Potentials Using Underlying Electroencephalogram Levels Improves Amplitude Reproducibility in Rats Free

PDF

Yuyi You; Johnson Thie; Alexander Klistorner; Vivek K. Gupta; Stuart L. Graham

Tags: electroencephalography, evoked potentials, visual, rats

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1473-1478. doi:https://doi.org/10.1167/iovs.11-8797

Visual Psychophysics and Physiological Optics

Effect of Blur Adaptation on Human Parafoveal Vision Free

PDF

Aleksandra Mankowska; Kiren Aziz; Matthew P. Cufflin; David Whitaker; Edward A. H. Mallen

Tags: parafoveal region, vision, refractive errors

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1145-1150. doi:https://doi.org/10.1167/iovs.11-8477

Comparative Resilience of Clinical Perimetric Tests to Induced Levels of Intraocular Straylight Free

PDF

Justyna D. Oleszczuk; Ciara Bergin; Eamon Sharkawi

Tags: perimetry, filters

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1219-1224. doi:https://doi.org/10.1167/iovs.11-8659

Clinical Trials

Assessment of Differential Pharmacodynamic Effects Using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration Free

PDF

Pearse A. Keane; Florian M. Heussen; Yanling Ouyang; Nils Mokwa; Alexander C. Walsh; Adnan Tufail; Srinivas R. Sadda; Praveen J. Patel

Tags: bevacizumab, exudative age-related macular degeneration, optical coherence tomography, pharmacodynamics, retina

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1152-1161. doi:https://doi.org/10.1167/iovs.11-8130

In Vivo Assessment of Antimicrobial Efficacy of Silver-Impregnated Contact Lens Storage Cases Free

PDF

Jaya Dantam; Hua Zhu; Mark Willcox; Jerome Ozkan; Thomas Naduvilath; Varghese Thomas; Fiona Stapleton

Tags: contact lens storage case, silver, antimicrobials

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1641-1648. doi:https://doi.org/10.1167/iovs.11-8197

Review

Expression and Role of p53 in the Retina Free

PDF

Linda Vuong; Shannon M. Conley; Muayyad R. Al-Ubaidi

Tags: apoptosis, cell death, mice, proteins, retina

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1362-1371. doi:https://doi.org/10.1167/iovs.11-8909

Letters to the Editor

Validation of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) in Age-Related Macular Degeneration Free

PDF

Jyoti Khadka; Colm McAlinden; Konrad Pesudovs

Tags: age-related macular degeneration, eye, questionnaires, vision

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1276. doi:https://doi.org/10.1167/iovs.12-9541

The Effect of the Anterior Ocular Structures on the Fluid Dynamics in Eyes with Gas Tamponades Free

PDF

Mahmut Dogramaci

Tags: eye, fluid dynamics

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1324. doi:https://doi.org/10.1167/iovs.12-9560

Correlation between Tear Matrix Metalloproteinases and the Schirmer's Test Free

PDF

Louis Tong; Andrea Petznick

Tags: matrix metalloproteinases

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1592. doi:https://doi.org/10.1167/iovs.12-9693

Morphometric Characteristics of Central Retinal Artery and Vein in the Optic Nerve Head of Patients with Diabetes Free

PDF

Galina Dimitrova

Tags: central retinal artery, diabetes mellitus, optic disk

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1637. doi:https://doi.org/10.1167/iovs.12-9572

Author Response: Morphometric Characteristics of Central Retinal Artery and Vein in the Optic Nerve Head of Patients with Diabetes Free

PDF

Dao-Yi Yu; Min H. Kang; Chandrakumar Balaratnasingam; Paula K. Yu; William H. Morgan; Ian L. McAllister; Stephen J. Cringle

Tags: central retinal artery, diabetes mellitus, optic disk

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1637-1638. doi:https://doi.org/10.1167/iovs.12-9703

Diurnal Variation of Retinal Thickness Measured by Optical Coherence Tomography in Normal Adults Free

PDF

Colin S. H. Tan; Wei Kiong Ngo; Milton C. Chew; Kelvin Z. Li; Louis W. Lim; Srinivas R. Sadda

Tags: adult, circadian rhythms, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1639. doi:https://doi.org/10.1167/iovs.12-9566

Author Response: Diurnal Variation of Retinal Thickness Measured by Optical Coherence Tomography in Normal Adults Free

PDF

Young-Joon Jo; Dong-Won Heo; Yong-IL Shin; Jung-Yeul Kim

Tags: adult, circadian rhythms, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1639-1640. doi:https://doi.org/10.1167/iovs.12-9772

Erratum

Erratum Free

PDF

Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1151. doi:https://doi.org/10.1167/iovs.11-7899a

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.