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Research Highlight

Mitochondrial Dysfunction in Glaucoma—Closing the Loop Free
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Patrick Yu-Wai-Man
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2438. doi:https://doi.org/10.1167/iovs.12-9815

Biochemistry and Molecular Biology

Anti-Retinal Antibodies in Serum of Laser-Treated Rabbits Free
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Sarah E. Scott; Rachida A. Bouhenni; Anthony M. Chomyk; Jeffrey J. Dunmire; Jayaprakash Patil; Hiroshi Nakamura; Deepak P. Edward
Tags: autoantigens, lasers, oryctolagus cuniculus, proteins, retinal antibodies
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1764-1772. doi:https://doi.org/10.1167/iovs.11-7685
Angiostatic Effect of CXCR3 Expressed on Choroidal Neovascularization Free
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Shigeto Fujimura; Hidenori Takahashi; Kentaro Yuda; Takashi Ueta; Aya Iriyama; Tatsuya Inoue; Toshikatsu Kaburaki; Yasuhiro Tamaki; Kouji Matsushima; Yasuo Yanagi
Tags: choroidal neovascularization, lasers, mice
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1999-2006. doi:https://doi.org/10.1167/iovs.11-8232
A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in the ABCA4 Gene Free
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Lars G. Fritsche; Monika Fleckenstein; Britta S. Fiebig; Steffen Schmitz-Valckenberg; Almut Bindewald-Wittich; Claudia N. Keilhauer; Agnes B. Renner; Friederike Mackensen; Andreas Mößner; Daniel Pauleikhoff; Christine Adrion; Ulrich Mansmann; Hendrik P. N. Scholl; Frank G. Holz; Bernhard H. F. Weber
Tags: age-related macular degeneration, alleles, genes, phenotype, atrophy
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2112-2118. doi:https://doi.org/10.1167/iovs.11-8785
Beta-Adrenoreceptor Agonism Influences Retinal Responses to Hypoxia in a Model of Retinopathy of Prematurity Free
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Massimo Dal Monte; Davide Martini; Valentina Latina; Barbara Pavan; Luca Filippi; Paola Bagnoli
Tags: hypoxia, isoproterenol, retina, retinopathy of prematurity, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2181-2192. doi:https://doi.org/10.1167/iovs.11-9408

Clinical and Epidemiologic Research

Contribution of Genetic and Environmental Effects on Lens Thickness: The Guangzhou Twin Eye Study Free
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Peiyang Shen; Xiaohu Ding; Yingfeng Zheng; Nathan G. Congdon; Mingguang He
Tags: eye, genes, genetics, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1758-1763. doi:https://doi.org/10.1167/iovs.11-9318
An Analysis of the Use of Multiple Comparison Corrections in Ophthalmology Research Free
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Andrew W. Stacey; Severin Pouly; Craig N. Czyz
Tags: ophthalmology, research personnel, type i errors, false-positive results
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1830-1834. doi:https://doi.org/10.1167/iovs.11-8730
Optic Disc Swelling in Vogt-Koyanagi-Harada Disease Free
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Kumiko Nakao; Noriko Abematsu; Yuka Mizushima; Taiji Sakamoto
Tags: edema, eye, papilledema, uveomeningoencephalitic syndrome, optic disk
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1917-1922. doi:https://doi.org/10.1167/iovs.11-8984
Explaining the Relationship between Three Eye Diseases and Depressive Symptoms in Older Adults Free
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Mihaela L. Popescu; Hélène Boisjoly; Heidi Schmaltz; Marie-Jeanne Kergoat; Jacqueline Rousseau; Solmaz Moghadaszadeh; Fawzia Djafari; Ellen E. Freeman
Tags: depressive disorders, eye diseases, older adult, mobility, glaucoma
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2308-2313. doi:https://doi.org/10.1167/iovs.11-9330

Cornea

Precision of High Definition Spectral-Domain Optical Coherence Tomography for Measuring Central Corneal Thickness Free
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María E. Correa-Pérez; Alberto López-Miguel; Silvia Miranda-Anta; Darío Iglesias-Cortiñas; Jorge L. Alió; Miguel J. Maldonado
Tags: cornea, optical coherence tomography, optical pachymetry, precision, reliability
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1752-1757. doi:https://doi.org/10.1167/iovs.11-9033
Mass Spectrometric Identification of Phospholipids in Human Tears and Tear Lipocalin Free
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Austin W. Dean; Ben J. Glasgow
Tags: phospholipids, lipids, mass spectrometry
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1773-1782. doi:https://doi.org/10.1167/iovs.11-9419
The Clinical Differentiation of Bacterial and Fungal Keratitis: A Photographic Survey Free
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Cyril Dalmon; Travis C. Porco; Thomas M. Lietman; N. Venkatesh Prajna; Lalitha Prajna; Mano Ranjan Das; J. Arun Kumar; Jeena Mascarenhas; Todd P. Margolis; John P. Whitcher; Bennie H. Jeng; Jeremy D. Keenan; Matilda F. Chan; Stephen D. McLeod; Nisha R. Acharya
Tags: fungal keratitis, surveys, clinicians, ulcer, keratitis
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1787-1791. doi:https://doi.org/10.1167/iovs.11-8478
Corneal Neurotoxicity Due to Topical Benzalkonium Chloride Free
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Joy Sarkar; Shweta Chaudhary; Abed Namavari; Okan Ozturk; Jin-Hong Chang; Lisette Yco; Snehal Sonawane; Vishakha Khanolkar; Joelle Hallak; Sandeep Jain
Tags: benzalkonium chloride, cornea, neurotoxicity syndromes, neurons
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1792-1802. doi:https://doi.org/10.1167/iovs.11-8775
Mapping the Corneal Sub-Basal Nerve Plexus in Orthokeratology Lens Wear Using in vivo Laser Scanning Confocal Microscopy Free
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Edward Lum; Blanka Golebiowski; Helen A. Swarbrick
Tags: cornea, lens (device), microscopy, confocal scanning laser, neurons, orthokeratology
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1803-1809. doi:https://doi.org/10.1167/iovs.11-8706
Vector Analysis of Corneal and Refractive Astigmatism Changes Following Toric Pseudophakic and Toric Phakic IOL Implantation Free
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Nienke Visser; Tos T. J. M. Berendschot; Noël J. C. Bauer; Rudy M. M. A. Nuijts
Tags: astigmatism, cornea, implantation procedure, spatial vectors, postoperative care
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1865-1873. doi:https://doi.org/10.1167/iovs.11-8868
Latent Dry Eye Disease State Variable Free
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Robert W. Massof; Peter J. McDonnell
Tags: dry eye syndromes, severity of illness
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1905-1916. doi:https://doi.org/10.1167/iovs.11-7768
Release of Vancomycin and Gentamicin from a Contact Lens Versus a Fibrin Coating Applied to a Contact Lens Free
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Alex J. T. Hyatt; Madhavan S. Rajan; Keith Burling; Matthew J. Ellington; Alessia Tassoni; Keith R. Martin
Tags: antibiotics, contact lenses, fibrin, gentamicin sulfate (usp), gentamicins
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1946-1952. doi:https://doi.org/10.1167/iovs.11-8607
Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease Free
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Michael E. Stern; Chris S. Schaumburg; Karyn F. Siemasko; Jianping Gao; Larry A. Wheeler; Devin A. Grupe; Cintia S. De Paiva; Virginia L. Calder; Margarita Calonge; Jerry Y. Niederkorn; Stephen C. Pflugfelder
Tags: autoantibodies, dry eye syndromes, mice, immunoglobulin g
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2062-2075. doi:https://doi.org/10.1167/iovs.11-9299
Fully Automated Montaging of Laser Scanning In Vivo Confocal Microscopy Images of the Human Corneal Subbasal Nerve Plexus Free
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Jason T. Turuwhenua; Dipika V. Patel; Charles N. J. McGhee
Tags: cornea, lasers, microscopy, confocal, neurons
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2235-2242. doi:https://doi.org/10.1167/iovs.11-8454
Collagenase-Mediated Tissue Modeling of Corneal Ectasia and Collagen Cross-Linking Treatments Free
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Cheng W. Hong; Abhijit Sinha-Roy; Lynn Schoenfield; James T. McMahon; William J. Dupps, Jr
Tags: body tissue, collagenase, corneal collagen cross-linking, corneal ectasia, dilatation, pathologic
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2321-2327. doi:https://doi.org/10.1167/iovs.11-9327
Flt23k Nanoparticles Offer Additive Benefit in Graft Survival and Anti-Angiogenic Effects When Combined with Triamcinolone Free
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Yang Kyung Cho; Hironori Uehara; Jason R. Young; Puneet Tyagi; Uday B. Kompella; Xiaohui Zhang; Ling Luo; Nirbhai Singh; Bonnie Archer; Balamurali K. Ambati
Tags: angiogenesis, graft survival, lymphangiogenesis, nanoparticles, neovascularization, pathologic
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2328-2336. doi:https://doi.org/10.1167/iovs.11-8393
An Accurate Method to Determine Bowman's Layer Thickness In Vivo in the Human Cornea Free
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Johan Germundsson; Per Fagerholm; Marina Koulikovska; Neil S. Lagali
Tags: bowman's layer, cornea, transplantation
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2354-2359. doi:https://doi.org/10.1167/iovs.11-8565
Photochemical Kinetics of Corneal Cross-Linking with Riboflavin Free
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Pavel Kamaev; Marc D. Friedman; Evan Sherr; David Muller
Tags: cornea, corneal collagen cross-linking, kinetics, mass or substance concentration per volume, oxygen
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2360-2367. doi:https://doi.org/10.1167/iovs.11-9385
Corneal and Retinal Effects of Ultraviolet-B Exposure in a Soft Contact Lens Mouse Model Free
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Osama M. A. Ibrahim; Takashi Kojima; Tais Hitomi Wakamatsu; Murat Dogru; Yukihiro Matsumoto; Yoko Ogawa; Junko Ogawa; Kazuno Negishi; Jun Shimazaki; Yasuo Sakamoto; Hiroshi Sasaki; Kazuo Tsubota
Tags: contact lenses, hydrophilic, cornea, mice, ultraviolet b radiation, immunohistochemistry
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2403-2413. doi:https://doi.org/10.1167/iovs.11-6863
Important Role of Epiregulin in Inflammatory Responses during Corneal Epithelial Wound Healing Free
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Yuan Zhang; Takeshi Kobayashi; Yasuhito Hayashi; Ryuji Yoshioka; Atsushi Shiraishi; Senji Shirasawa; Shigeki Higashiyama; Yuichi Ohashi
Tags: cornea, epithelium, mice, wound healing, wounds and injuries
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2414-2423. doi:https://doi.org/10.1167/iovs.11-8869

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Genomic Profiling Reveals Pitx2 Controls Expression of Mature Extraocular Muscle Contraction–Related Genes Free
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Yuefang Zhou; Bendi Gong; Henry J. Kaminski
Tags: gene expression profiling, genes, muscle of orbit, proteins, mice
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1821-1829. doi:https://doi.org/10.1167/iovs.12-9481
Scanning Laser Polarimetry Reveals Status of RNFL Integrity in Eyes with Optic Nerve Head Swelling by OCT Free
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Mark J. Kupersmith; Randy Kardon; Mary Durbin; Melissa Horne; Julia Shulman
Tags: edema, eye, nonarteritic anterior ischemic optic neuropathy, optic disk, optic neuritis
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1962-1970. doi:https://doi.org/10.1167/iovs.11-9339
Conjugate Adaptation of Smooth Pursuit during Monocular Viewing in Strabismic Monkeys with Exotropia Free
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Seiji Ono; Vallabh E. Das; Michael J. Mustari
Tags: cercopithecidae, exotropia, eye, pursuit, smooth
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2038-2045. doi:https://doi.org/10.1167/iovs.11-9011

Genetics

Evaluation of SNPs on Chromosome 2p with Primary Open Angle Glaucoma in the South Indian Cohort Free
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Suganthalakshmi Balasubbu; Subbaiah R. Krishnadas; Xiaodong Jiao; J. Fielding Hejtmancik; Periasamy Sundaresan
Tags: chromosomes, cohort studies, glaucoma, open-angle glaucoma, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1861-1864. doi:https://doi.org/10.1167/iovs.11-8602
Multigene Methylation Analysis of Ocular Adnexal MALT Lymphoma and Their Relationship to Chlamydophila psittaci Infection and Clinical Characteristics in South Korea Free
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Ho-Kyung Choung; Young A. Kim; Min Joung Lee; Namju Kim; Sang In Khwarg
Tags: chlamydophila psittaci, dna, infections, korea, lymphoma, mucosa-associated lymphoid tissue
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1928-1935. doi:https://doi.org/10.1167/iovs.11-7668
Replication Analysis for Severe Diabetic Retinopathy Free
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Michael A. Grassi; Anna Tikhomirov; Sudha Ramalingam; Kristine E. Lee; S. M. Hosseini; Barbara E. K. Klein; Ronald Klein; Yves A. Lussier; Nancy J. Cox; Dan L. Nicolae
Tags: cohort studies, diabetic retinopathy, retinal diseases, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2377-2381. doi:https://doi.org/10.1167/iovs.11-8068

Glaucoma

Imaging of the Iridocorneal Angle with the RTVue Spectral Domain Optical Coherence Tomography Free
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Shamira A. Perera; Ching Lin Ho; Tin Aung; Mani Baskaran; Henrietta Ho; Tin A. Tun; Tian Loon Lee; Rajesh S. Kumar
Tags: diagnostic imaging, gonioscopy, optical coherence tomography
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1710-1713. doi:https://doi.org/10.1167/iovs.11-8159
Biomechanics of the Human Posterior Sclera: Age- and Glaucoma-Related Changes Measured Using Inflation Testing Free
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Baptiste Coudrillier; Jing Tian; Stephen Alexander; Kristin M. Myers; Harry A. Quigley; Thao D. Nguyen
Tags: glaucoma, sclera, economic inflation, eye
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1714-1728. doi:https://doi.org/10.1167/iovs.11-8009
Altered Stability of mRNAs Associated with Glaucoma Progression in Human Trabecular Meshwork Cells Following Oxidative Stress Free
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Hideki Mochizuki; Christopher J. Murphy; James D. Brandt; Yoshiaki Kiuchi; Paul Russell
Tags: glaucoma, oxidative stress, rna, messenger, trabecular meshwork, interleukin-6
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1734-1741. doi:https://doi.org/10.1167/iovs.12-7938
Influence of Clinically Invisible, but Optical Coherence Tomography Detected, Optic Disc Margin Anatomy on Neuroretinal Rim Evaluation Free
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Alexandre S. C. Reis; Neil O'Leary; Hongli Yang; Glen P. Sharpe; Marcelo T. Nicolela; Claude F. Burgoyne; Balwantray C. Chauhan
Tags: neuroretinal rim, optic disk, optical coherence tomography, glaucoma
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1852-1860. doi:https://doi.org/10.1167/iovs.11-9309
Elevation of Serum Asymmetrical and Symmetrical Dimethylarginine in Patients with Advanced Glaucoma Free
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Shahrbanou Javadiyan; Kathryn P. Burdon; Malcolm J. Whiting; Sotoodeh Abhary; Tania Straga; Alex W. Hewitt; Richard A. Mills; Jamie E. Craig
Tags: glaucoma, n,n-dimethylarginine
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1923-1927. doi:https://doi.org/10.1167/iovs.11-8420
Hydrocortisone Stimulates Neurite Outgrowth from Mouse Retinal Explants by Modulating Macroglial Activity Free
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Kimberly A. Toops; Cynthia Berlinicke; Donald J. Zack; Robert W. Nickells
Tags: hydrocortisone, mice, neurites, ciliary neurotrophic factor, glial fibrillary acidic protein
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2046-2061. doi:https://doi.org/10.1167/iovs.11-8646
In Situ Autofluorescence Visualization of Human Trabecular Meshwork Structure Free
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James C. H. Tan; Jose M. Gonzalez, Jr; Sarah Hamm-Alvarez; Jonathan Song
Tags: autofluorescence, body tissue, excitation, trabecular meshwork, uvea
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2080-2088. doi:https://doi.org/10.1167/iovs.11-8141
Incorporating Risk Factors to Improve the Assessment of Rates of Glaucomatous Progression Free
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Felipe A. Medeiros; Linda M. Zangwill; Kaweh Mansouri; Renato Lisboa; Ali Tafreshi; Robert N. Weinreb
Tags: glaucoma, risk factors, visual fields, eye, follow-up
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2199-2207. doi:https://doi.org/10.1167/iovs.11-8639
Glaucoma Diagnostic Ability of Quadrant and Clock-Hour Neuroretinal Rim Assessment Using Cirrus HD Optical Coherence Tomography Free
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Young Hoon Hwang; Yong Yeon Kim
Tags: glaucoma, neuroretinal rim, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2226-2234. doi:https://doi.org/10.1167/iovs.11-8689
Hypoxia Regulated Gene Transcription in Human Optic Nerve Lamina Cribrosa Cells in Culture Free
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Ruaidhrí P. Kirwan; Luca Felice; Abbot F. Clark; Colm J. O'Brien; Martin O. Leonard
Tags: cribriform plate, hypoxia, polymerase chain reaction, transcription, genetic, optic nerve
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2243-2255. doi:https://doi.org/10.1167/iovs.11-6729
Classification Algorithms Enhance the Discrimination of Glaucoma from Normal Eyes Using High-Definition Optical Coherence Tomography Free
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Mani Baskaran; Ee-Lin Ong; Jia-Liang Li; Carol Y. Cheung; David Chen; Shamira A. Perera; Ching Lin Ho; Ying-Feng Zheng; Tin Aung
Tags: eye, glaucoma, optical coherence tomography, retinal nerve fiber layer, optic disk
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2314-2320. doi:https://doi.org/10.1167/iovs.11-8035
Structure/Function Studies and the Effects of Memantine in Monkeys with Experimental Glaucoma Free
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B'Ann T. Gabelt; Carol A. Rasmussen; Ozan Y. Tektas; Charlene B. Y. Kim; John C. Peterson; T. Michael Nork; James N. Ver Hoeve; Elke Lütjen-Drecoll; Paul L. Kaufman
Tags: axon, cercopithecidae, eye, glaucoma, memantine
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2368-2376. doi:https://doi.org/10.1167/iovs.11-8475
Predicting Glaucomatous Progression in Glaucoma Suspect Eyes Using Relevance Vector Machine Classifiers for Combined Structural and Functional Measurements Free
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Christopher Bowd; Intae Lee; Michael H. Goldbaum; Madhusudhanan Balasubramanian; Felipe A. Medeiros; Linda M. Zangwill; Christopher A. Girkin; Jeffrey M. Liebmann; Robert N. Weinreb
Tags: disease vectors, eye, functional measures, glaucoma, spatial vectors
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2382-2389. doi:https://doi.org/10.1167/iovs.11-7951
Pointwise Rates of Visual Field Progression Cluster according to Retinal Nerve Fiber Layer Bundles Free
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Kouros Nouri-Mahdavi; Dennis Mock; Hamid Hosseini; Elena Bitrian; Fei Yu; Abdelmonem Afifi; Anne L. Coleman; Joseph Caprioli
Tags: retinal nerve fiber layer, visual fields, glaucoma
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2390-2394. doi:https://doi.org/10.1167/iovs.11-9021
The Effect of Glaucoma on the Optical Attenuation Coefficient of the Retinal Nerve Fiber Layer in Spectral Domain Optical Coherence Tomography Images Free
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Josine van der Schoot; Koenraad A. Vermeer; Johannes F. de Boer; Hans G. Lemij
Tags: attenuation, glaucoma, optical coherence tomography, optics, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2424-2430. doi:https://doi.org/10.1167/iovs.11-8436
Impaired Complex-I-Linked Respiration and ATP Synthesis in Primary Open-Angle Glaucoma Patient Lymphoblasts Free
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Shanjean Lee; Leo Sheck; Jonathan G. Crowston; Nicole J. Van Bergen; Evelyn C. O'Neill; Fleur O'Hare; Yu Xiang George Kong; Vicki Chrysostomou; Andrea L. Vincent; Ian A. Trounce
Tags: lymphoblasts, open-angle glaucoma, respiration
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2431-2437. doi:https://doi.org/10.1167/iovs.12-9596
Ophthalmic Artery Doppler Waveform Changes Associated with Increased Damage in Glaucoma Patients Free
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Luís Abegão Pinto; Evelien Vandewalle; Eline De Clerck; Carlos Marques-Neves; Ingeborg Stalmans
Tags: glaucoma, ophthalmic artery, waveforms, open-angle glaucoma
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2448-2453. doi:https://doi.org/10.1167/iovs.11-9388

Lens

Induction of Posterior Capsule Opacification by Hyaluronic Acid in an Ex Vivo Model Free
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Heather L. Chandler; David J. Haeussler, Jr; Anne J. Gemensky-Metzler; David A. Wilkie; Elizabeth A. Lutz
Tags: after-cataract, cd44 antigens, dog, domestic, homing-associated cell adhesion molecule, hyaluronic acid
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1835-1845. doi:https://doi.org/10.1167/iovs.11-8735
Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts Free
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Kanji Hori; Akira Matsuda; Nobuyuki Ebihara; Kojiro Imai; Kazuhiko Mori; Toshinari Funaki; Yasuo Watanabe; Satoru Nakatani; Kiyotaka Okada; Osamu Matsuo; Akira Murakami
Tags: cataract, plasminogen activator inhibitor 1, rna, messenger, pathogenesis, proteins
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1846-1851. doi:https://doi.org/10.1167/iovs.11-8380
Nanomechanical Characterization of the Stiffness of Eye Lens Cells: A Pilot Study Free
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Amela Hozic; Felix Rico; Adai Colom; Nikolay Buzhynskyy; Simon Scheuring
Tags: lens cell, lens, crystalline, pilot projects, cytoskeleton, lens (device)
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2151-2156. doi:https://doi.org/10.1167/iovs.11-8676

Low Vision

Preferred Retinal Locus—Hand Coordination in a Maze-Tracing Task Free
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George T. Timberlake; Evanthia Omoscharka; Susan A. Grose; Rebecca Bothwell
Tags: fovea centralis, hand, scotoma
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1810-1820. doi:https://doi.org/10.1167/iovs.11-9282

Multidisciplinary Ophthalmic Imaging

Image Inversion Spectral-Domain Optical Coherence Tomography Optimizes Choroidal Thickness and Detail through Improved Contrast Free
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Phoebe Lin; Priyatham S. Mettu; Dustin L. Pomerleau; Stephanie J. Chiu; Ramiro Maldonado; Sandra Stinnett; Cynthia A. Toth; Sina Farsiu; Prithvi Mruthyunjaya
Tags: diagnostic imaging, eye, optical coherence tomography, choroid, software
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1874-1882. doi:https://doi.org/10.1167/iovs.11-9290
Signal Quality Assessment of Retinal Optical Coherence Tomography Images Free
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Yijun Huang; Sapna Gangaputra; Kristine E. Lee; Ashwini R. Narkar; Ronald Klein; Barbara E. K. Klein; Stacy M. Meuer; Ronald P. Danis
Tags: body tissue, healthcare quality assessment, optical coherence tomography, pixel
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2133-2141. doi:https://doi.org/10.1167/iovs.11-8755
Peripheral Fundus Autofluorescence Is Increased in Age-Related Macular Degeneration Free
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Lukas Reznicek; Tamer Wasfy; Carmen Stumpf; Anselm Kampik; Michael Ulbig; Aljoscha S. Neubauer; Marcus Kernt
Tags: age-related macular degeneration, anti-vascular endothelial growth factor therapy, eye, fundus autofluorescence imaging, autofluorescence
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2193-2198. doi:https://doi.org/10.1167/iovs.11-8483
Circadian Changes in Subfoveal Choroidal Thickness and the Relationship with Circulatory Factors in Healthy Subjects Free
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Shinichi Usui; Yasushi Ikuno; Masahiro Akiba; Ichiro Maruko; Tetsuju Sekiryu; Kohji Nishida; Tomohiro Iida
Tags: choroid, eye, intraocular pressure, mopp protocol, night time
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2300-2307. doi:https://doi.org/10.1167/iovs.11-8383

Nantotechnology and Regenerative Medicine

A Novel Cyclosporin A Aqueous Formulation for Dry Eye Treatment: In Vitro and In Vivo Evaluation Free
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Claudia Di Tommaso; Fatemeh Valamanesh; Florence Miller; Pascal Furrer; Marta Rodriguez-Aller; Francine Behar-Cohen; Robert Gurny; Michael Möller
Tags: cornea, cyclosporine, dry eye syndromes, micelles, eye
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2292-2299. doi:https://doi.org/10.1167/iovs.11-8829

Physiology and Pharmacology

Retinal Oximetry Images Must Be Standardized: A Methodological Analysis Free
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Olafur Palsson; Asbjorg Geirsdottir; Sveinn Hakon Hardarson; Olof Birna Olafsdottir; Jona Valgerdur Kristjansdottir; Einar Stefánsson
Tags: gaze, oximetry, venule, oxygen saturation measurement, arteriole
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1729-1733. doi:https://doi.org/10.1167/iovs.11-8621
Lactate-H+ Transport Is a Significant Component of the In Vivo Corneal Endothelial Pump Free
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Tracy T. Nguyen; Joseph A. Bonanno
Tags: biological transport, cornea, corneal endothelium, endothelium, lactates
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2020-2029. doi:https://doi.org/10.1167/iovs.12-9475
Stimulation of Aquaporin-Mediated Fluid Transport by Cyclic GMP in Human Retinal Pigment Epithelium In Vitro Free
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Nicholas W. Baetz; W. Daniel Stamer; Andrea J. Yool
Tags: aquaporin 1, cyclic gmp, fluid transport, retinal pigment epithelium, water channels
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2127-2132. doi:https://doi.org/10.1167/iovs.11-8471

Retina

Is Drusen Area Really So Important? An Assessment of Risk of Conversion to Neovascular AMD Based on Computerized Measurements of Drusen Free
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Thomas R. Friberg; Richard A. Bilonick; Peter Brennen
Tags: drusen, exudative age-related macular degeneration, eye, risk assessment
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1742-1751. doi:https://doi.org/10.1167/iovs.11-9338
Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats Free
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Wen-Tao Deng; Astra Dinculescu; Qiuhong Li; Sanford L. Boye; Jie Li; Marina S. Gorbatyuk; Jijing Pang; Vince A. Chiodo; Michael T. Matthes; Douglas Yasumura; Li Liu; Fowzan S. Alkuraya; Kang Zhang; Douglas Vollrath; Matthew M. LaVail; William W. Hauswirth
Tags: eye, mertk gene, rats, tyrosine, retina
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1895-1904. doi:https://doi.org/10.1167/iovs.11-8831
Creatine Transporter Immunolocalization in Aged Human and Detached Retinas Free
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Clairton F. de Souza; Michael Kalloniatis; David L. Christie; Philip J. Polkinghorne; Charles N. J. McGhee; Monica L. Acosta
Tags: creatine, membrane transport proteins, retina, retinal detachment
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1936-1945. doi:https://doi.org/10.1167/iovs.11-8462
Retinal Intrinsic Optical Signals in a Cat Model of Primary Congenital Glaucoma Free
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Jesse B. Schallek; Gillian J. McLellan; Suresh Viswanathan; Daniel Y. Ts'o
Tags: adaptive testing, cats, glaucoma, glaucoma, congenital, optics
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1971-1981. doi:https://doi.org/10.1167/iovs.11-8299
In Vivo Assessment of Thickness and Reflectivity in a Rat Outer Retinal Degeneration Model with Ultrahigh Resolution Optical Coherence Tomography Free
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Sepideh Hariri; Alireza A. Moayed; Vivian Choh; Kostadinka Bizheva
Tags: optical coherence tomography, retinal degeneration, iodates, sodium, retina
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1982-1989. doi:https://doi.org/10.1167/iovs.11-8395
Ephrin-A4 Is Involved in Retinal Neovascularization by Regulating the VEGF Signaling Pathway Free
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Wei Du; Wenzhen Yu; Lvzhen Huang; Min Zhao; Xiaoxin Li
Tags: ephrins, vascular endothelial growth factor a, signal pathway, signal transduction pathways, retinal neovascularization
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1990-1998. doi:https://doi.org/10.1167/iovs.11-8788
Nasal Ciliary Beat Frequency and Beat Pattern in Retinal Ciliopathies Free
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Miguel Armengot; David Salom; Manuel Diaz-Llopis; Jose M. Millan; Javier Milara; Manuel Mata; Julio Cortijo
Tags: ciliopathies, nose, usher syndrome
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2076-2079. doi:https://doi.org/10.1167/iovs.11-8666
DNA Methylation Is Associated with Altered Gene Expression in AMD Free
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Allan Hunter; Paul A. Spechler; Alyssa Cwanger; Ying Song; Zhe Zhang; Gui-shuang Ying; Anna K. Hunter; Edwin deZoeten; Joshua L. Dunaief
Tags: choroid, dna, dna methylation, gene expression, genes
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2089-2105. doi:https://doi.org/10.1167/iovs.11-8449
Measurement of Macular Pigment Optical Density in a Healthy Chinese Population Sample Free
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Jie Yu; Elizabeth J. Johnson; Fu Shang; Apiradee Lim; Haiying Zhou; Lei Cui; Jun Xu; Torkel Snellingen; Xipu Liu; Ningli Wang; Ningpu Liu
Tags: chinese (other dialects), chinese people, optics, pigment
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2106-2111. doi:https://doi.org/10.1167/iovs.11-8518
Does Increased Blood Pressure Rather Than Aging Influence Retinal Pulse Wave Velocity? Free
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Konstantin E. Kotliar; Ines M. Lanzl; Henner Hanssen; Karla Eberhardt; Walthard Vilser; Martin Halle; Uwe Heemann; Arno Schmidt-Trucksäss; Marcus Baumann
Tags: aging, blood pressure, diameter, hypertension, pulse wave velocity
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2119-2126. doi:https://doi.org/10.1167/iovs.11-8815
Electrophysiological Findings in a Porcine Model of Selective Retinal Capillary Closure Free
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Chi D. Luu; Wallace S. Foulds; Charanjit Kaur
Tags: blood capillaries, electroretinography, erg protein, human, eye, microspheres
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2218-2225. doi:https://doi.org/10.1167/iovs.11-8490
Dietary Docosahexaenoic Acid Supplementation Prevents Age-Related Functional Losses and A2E Accumulation in the Retina Free
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Blake Dornstauder; Miyoung Suh; Sharee Kuny; Frédéric Gaillard; Ian M. MacDonald; Michael T. Clandinin; Yves Sauvé
Tags: diet, docosahexaenoic acids, mice, retina, retinal degeneration
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2256-2265. doi:https://doi.org/10.1167/iovs.11-8569
Repeatability and Reproducibility of Manual Choroidal Volume Measurements Using Enhanced Depth Imaging Optical Coherence Tomography Free
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Jay Chhablani; Giulio Barteselli; Haiyan Wang; Sharif El-Emam; Igor Kozak; Aubrey L. Doede; Dirk-Uwe Bartsch; Lingyun Cheng; William R. Freeman
Tags: diagnostic imaging, optical coherence tomography, volume
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2274-2280. doi:https://doi.org/10.1167/iovs.12-9435
In Vivo Human Choroidal Vascular Pattern Visualization Using High-Speed Swept-Source Optical Coherence Tomography at 1060 nm Free
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Reza Motaghiannezam; Daniel M. Schwartz; Scott E. Fraser
Tags: diagnostic imaging, face, optic disk, optical coherence tomography, tomography
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2337-2348. doi:https://doi.org/10.1167/iovs.11-7823
Vascular Endothelial Growth Factor Gene Polymorphisms and Choroidal Neovascularization in Highly Myopic Eyes Free
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Yumiko Akagi-Kurashige; Kyoko Kumagai; Kenji Yamashiro; Hideo Nakanishi; Isao Nakata; Masahiro Miyake; Akitaka Tsujikawa; Muka Moriyama; Kyoko Ohno-Matsui; Manabu Mochizuki; Ryo Yamada; Fumihiko Matsuda; Nagahisa Yoshimura
Tags: choroidal neovascularization, eye, genes, polymorphism, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2349-2353. doi:https://doi.org/10.1167/iovs.11-9405

Retinal Cell Biology

Autosomal Recessive Retinitis Pigmentosa Due To ABCA4 Mutations: Clinical, Pathologic, and Molecular Characterization Free
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Robert F. Mullins; Markus H. Kuehn; Roxana A. Radu; G. Stephanie Enriquez; Jade S. East; Emily I. Schindler; Gabriel H. Travis; Edwin M. Stone
Tags: autosomal recessive inheritance, donors, eye, genes, mutation
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1883-1894. doi:https://doi.org/10.1167/iovs.12-9477
Matrix Metalloproteinase Activity Creates Pro-Angiogenic Environment in Primary Human Retinal Pigment Epithelial Cells Exposed to Complement Free
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Mausumi Bandyopadhyay; Bärbel Rohrer
Tags: angiogenesis, complement activation, complement system proteins, gelatinase a, matrix metalloproteinases
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1953-1961. doi:https://doi.org/10.1167/iovs.11-8638
Blood-Derived Human iPS Cells Generate Optic Vesicle–Like Structures with the Capacity to Form Retinal Laminae and Develop Synapses Free
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M. Joseph Phillips; Kyle A. Wallace; Sarah J. Dickerson; Michael J. Miller; Amelia D. Verhoeven; Jessica M. Martin; Lynda S. Wright; Wei Shen; Elizabeth E. Capowski; E. Ferda Percin; Enio T. Perez; Xiufeng Zhong; Maria V. Canto-Soler; David M. Gamm
Tags: genes, immunocytochemistry, neurons, optic vesicle, pluripotent stem cells
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2007-2019. doi:https://doi.org/10.1167/iovs.11-9313
Nerve Growth Factor Promotes Endothelial Progenitor Cell-Mediated Angiogenic Responses Free
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Chandrakala S. Jadhao; Ashay D. Bhatwadekar; Youde Jiang; Michael E. Boulton; Jena J. Steinle; Maria B. Grant
Tags: angiogenesis, cd34 antigens, nerve growth factors, endothelium
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2030-2037. doi:https://doi.org/10.1167/iovs.11-8430
GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy Free
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Deeksha Gambhir; Sudha Ananth; Rajalakshmi Veeranan-Karmegam; Selvakumar Elangovan; Shanterian Hester; Eric Jennings; Stefan Offermanns; Julian J. Nussbaum; Sylvia B. Smith; Muthusamy Thangaraju; Vadivel Ganapathy; Pamela M. Martin
Tags: anti-inflammatory agents, diabetes mellitus, diabetic retinopathy, interleukin-6, monocyte chemoattractant protein-1
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2208-2217. doi:https://doi.org/10.1167/iovs.11-8447
Glucosamine Modulates TNF-α–Induced ICAM-1 Expression and Function Through O-Linked and N-Linked Glycosylation in Human Retinal Pigment Epithelial Cells Free
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Ching-Long Chen; Chang-Min Liang; Yi-Hao Chen; Ming-Cheng Tai; Da-Wen Lu; Jiann-Torng Chen
Tags: glycosylation, intercellular adhesion molecule 1, proteins, tumor necrosis factors, glucosamine
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2281-2291. doi:https://doi.org/10.1167/iovs.11-9291
Effect of Berberine on Proinflammatory Cytokine Production by ARPE-19 Cells following Stimulation with Tumor Necrosis Factor-α Free
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Qian Wang; Jian Qi; Ranran Hu; Ying Chen; Aize Kijlstra; Peizeng Yang
Tags: berberine, cytokine, interleukin-6, interleukin-8, monocyte chemoattractant protein-1
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2395-2402. doi:https://doi.org/10.1167/iovs.11-8982

Translational

AMG 386, a Selective Angiopoietin 1/2-Neutralizing Peptibody, Inhibits Angiogenesis in Models of Ocular Neovascular Diseases Free
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Jonathan D. Oliner; James Bready; Linh Nguyen; Juan Estrada; Eunju Hurh; Hongjin Ma; James Pretorius; William Fanslow; T. Michael Nork; Robert A. Leedle; Stephen Kaufman; Angela Coxon
Tags: angiogenesis, angiopoietins, choroidal neovascularization, lasers, longitudinal relaxation rate
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2170-2180. doi:https://doi.org/10.1167/iovs.11-7381
Intra-Ophthalmic Artery Chemotherapy Triggers Vascular Toxicity through Endothelial Cell Inflammation and Leukostasis Free
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Jena J. Steinle; Qiuhua Zhang; Karin Emmons Thompson; Jordan Toutounchian; C. Ryan Yates; Carl Soderland; Fan Wang; Clinton F. Stewart; Barrett G. Haik; J. Scott Williams; J. Scott Jackson; Timothy D. Mandrell; Dianna Johnson; Matthew W. Wilson
Tags: chemotherapy regimen, endothelial cells, eye, inflammation, leukostasis
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2439-2445. doi:https://doi.org/10.1167/iovs.12-9466

Visual Neuroscience

Localization of Hemodynamic Responses to Simple Visual Stimulation: An fNIRS Study Free
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Sobanawartiny Wijeakumar; Uma Shahani; William A. Simpson; Daphne L. McCulloch
Tags: hemodynamics, hyperbaric oxygenation, photic stimulation, mass or substance concentration per volume, scalp
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2266-2273. doi:https://doi.org/10.1167/iovs.11-8680

Clinical Trials

Effect of Treatment on the Rate of Visual Field Change in the Ocular Hypertension Treatment Study Observation Group Free
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Carlos Gustavo De Moraes; Shaban Demirel; Stuart K. Gardiner; Jeffrey M. Liebmann; George A. Cioffi; Robert Ritch; Mae O. Gordon; Michael A. Kass; For the Ocular Hypertension Treatment Study Group
Tags: eye, ocular hypertension, open-angle glaucoma, velocity, visual fields
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1704-1709. doi:https://doi.org/10.1167/iovs.11-8186
Subthreshold Laser Treatment Versus Threshold Laser Treatment for Symptomatic Retinal Arterial Macroaneurysm Free
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Maurizio Battaglia Parodi; Pierluigi Iacono; Luisa Pierro; Alessandro Papayannis; Stelyos Kontadakis; Francesco M. Bandello
Tags: laser therapy, retinal arterial macroaneurysm, follow-up
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 1783-1786. doi:https://doi.org/10.1167/iovs.11-8772
Randomized Controlled Trial on the Effects of Training in the Use of Closed-Circuit Television on Reading Performance Free
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Marloes C. Burggraaff; Ruth M. A. van Nispen; Frank P. Hoeben; Dirk L. Knol; Ger H. M. B. van Rens
Tags: closed circuit television, randomized controlled trial, reading (activity), training, follow-up
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2142-2150. doi:https://doi.org/10.1167/iovs.11-8407
TMP Prevents Retinal Neovascularization and Imparts Neuroprotection in an Oxygen-Induced Retinopathy Model Free
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Xiaoling Liang; Huanjiao Zhou; Yungang Ding; Jie Li; Cheng Yang; Yan Luo; Shiqing Li; Gang Sun; Xulong Liao; Wang Min
Tags: mice, neuroprotection, oxygen, retina, retinal diseases
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2157-2169. doi:https://doi.org/10.1167/iovs.11-9315

Obituary

Remembering Joanne Angle, 1941−2012 Free
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Paul L. Kaufman
Investigative Ophthalmology & Visual Science April 2012, Vol.53, 2446-2447. doi:https://doi.org/10.1167/iovs.12-9946
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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