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Research Highlight

Corneal Genetics: Using Ancestry to Dissect Quantitative Traits for Complex Disease Discovery Free
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Alex W. Hewitt
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2444. doi:https://doi.org/10.1167/iovs.13-12029
Medical Treatment of Fuchs' Dystrophy in our Lifetime? Free
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Kathryn Colby
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2503. doi:https://doi.org/10.1167/iovs.13-12034
Mini-Chaperones for Early AMD Free
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Jeffrey H. Stern
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2799. doi:https://doi.org/10.1167/iovs.13-12101
Spotlight Summary: Quantitative Fundus Autofluorescence and A2E Increase With Aging in Wild-Type and “Stargardt” Mice Free
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Robert Zawadzki; Edward N. Pugh, Jr.
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2991. doi:https://doi.org/10.1167/iovs.13-12252

Anatomy and Pathology/Oncology

Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse Free
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Yanrong Shi; Yidong Tu; Alicia De Maria; Robert P. Mecham; Steven Bassnett
Tags: eye, lens (device), lens, crystalline, mice, suspensory ligament of lens
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2504-2515. doi:https://doi.org/10.1167/iovs.13-11619
Eyes in Various Species Can Shorten to Compensate for Myopic Defocus Free
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Xiaoying Zhu; Neville A. McBrien; Earl L. Smith, III; David Troilo; Josh Wallman
Tags: eye, lens (device), lens, crystalline, myopia
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2634-2644. doi:https://doi.org/10.1167/iovs.12-10514
Negative Lens–Induced Myopia in Infant Monkeys: Effects of High Ambient Lighting Free
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Earl L. Smith, III; Li-Fang Hung; Baskar Arumugam; Juan Huang
Tags: cercopithecidae, infant, lens (device), lens, crystalline, lighting
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2959-2969. doi:https://doi.org/10.1167/iovs.13-11713

Biochemistry and Molecular Biology

Regulation of SPARC by Transforming Growth Factor β2 in Human Trabecular Meshwork Free
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Min Hyung Kang; Dong-Jin Oh; Ja-heon Kang; Douglas J. Rhee
Tags: sparc study, trabecular meshwork, up-regulation (physiology), transforming growth factor alpha, transforming growth factors
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2523-2532. doi:https://doi.org/10.1167/iovs.12-11474

Clinical and Epidemiologic Research

Retinal and Choroidal Thickness in Myopic Anisometropia Free
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Stephen J. Vincent; Michael J. Collins; Scott A. Read; Leo G. Carney
Tags: anisometropia, eye, refractive errors, nose, fovea centralis
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2445-2456. doi:https://doi.org/10.1167/iovs.12-11434
Prevalence of Refractive Errors in a Multiethnic Asian Population: The Singapore Epidemiology of Eye Disease Study Free
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Chen-Wei Pan; Ying-Feng Zheng; Ainur Rahman Anuar; Merwyn Chew; Gus Gazzard; Tin Aung; Ching-Yu Cheng; Tien Y. Wong; Seang-Mei Saw
Tags: asian, eye diseases, myopia, prevalence, refractive errors
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2590-2598. doi:https://doi.org/10.1167/iovs.13-11725
Associations of Iris Structural Measurements in a Chinese Population: The Singapore Chinese Eye Study Free
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Chelvin C. Sng; John C. Allen; Monisha E. Nongpiur; Li-Lian Foo; Yingfeng Zheng; Carol Y. Cheung; Mingguang He; David S. Friedman; Tien Y. Wong; Tin Aung
Tags: chinese (other dialects), chinese people, eye, immune reconstitution inflammatory syndrome, iris
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2829-2835. doi:https://doi.org/10.1167/iovs.12-11250
Investigating the Relationship Between Foveal Morphology and Refractive Error in a Population With Infantile Nystagmus Syndrome Free
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Natasha Healey; Eibhlin McLoone; Gerald Mahon; A. Jonathan Jackson; Kathryn J. Saunders; Julie F. McClelland
Tags: foveal hypoplasia, pathologic nystagmus, refractive errors, syndrome, language morphology
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2934-2939. doi:https://doi.org/10.1167/iovs.12-11537
Structural Changes in the Retinal Microvasculature and Renal Function Free
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Laurence Shen Lim; Carol Yim-lui Cheung; Charumathi Sabanayagam; Su Chi Lim; E. Shyong Tai; Lei Huang; Tien Yin Wong
Tags: diabetes mellitus, hypertension, kidney failure, chronic, microalbuminuria, renal function
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2970-2976. doi:https://doi.org/10.1167/iovs.13-11941
Clinical, Radiologic, and Genetic Features in Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome in the Indian Population Free
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Bhavna Chawla; Yogesh Bhadange; Rima Dada; Manoj Kumar; Sanjay Sharma; Mandeep S. Bajaj; Neelam Pushker; Mahesh Chandra; Supriyo Ghose
Tags: blepharophimosis, blepharophimosis syndrome, epicanthus inversus, eyelid ptosis, genetics
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2985-2991. doi:https://doi.org/10.1167/iovs.13-11794
Racial Differences in Lens Opacity Incidence and Progression: The Salisbury Eye Evaluation (SEE) Study Free
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Philip Storey; Beatriz Munoz; David Friedman; Sheila West
Tags: cataract, eye, incidence, signing exact english, racial differences
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3010-3018. doi:https://doi.org/10.1167/iovs.12-11412

Cornea

Interaction Between Conjunctival Epithelial Cells and Mast Cells Induces CCL2 Expression and Piecemeal Degranulation in Mast Cells Free
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Satoshi Iwamoto; Yosuke Asada; Nobuyuki Ebihara; Kanji Hori; Yoshimichi Okayama; Jun-ichi Kashiwakura; Yasuo Watanabe; Satoshi Kawasaki; Norihiko Yokoi; Tsutomu Inatomi; Katsuhiko Shinomiya; Akira Murakami; Akira Matsuda
Tags: mast cells, monocyte chemoattractant protein-1, conjunctival epithelial cells
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2465-2473. doi:https://doi.org/10.1167/iovs.12-10664
Evaluation of Corneal Displacement Using High-Speed Photography at the Early and Late Phases of Noncontact Tonometry Free
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Shunsuke Nakakura; Yoshiaki Kiuchi; Makoto Kaneko; Hideki Mochizuki; Joji Takenaka; Kenji Yamada; Yosuke Kimura; Hitoshi Tabuchi
Tags: cornea, non-contact tonometry
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2474-2482. doi:https://doi.org/10.1167/iovs.12-11424
The ROCK Inhibitor Eye Drop Accelerates Corneal Endothelium Wound Healing Free
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Naoki Okumura; Noriko Koizumi; EunDuck P. Kay; Morio Ueno; Yuji Sakamoto; Shinichiro Nakamura; Junji Hamuro; Shigeru Kinoshita
Tags: cornea, corneal endothelium, eyedrops, wound healing, recovery of function
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2493-2502. doi:https://doi.org/10.1167/iovs.12-11320
Lacritin-Induced Secretion of Tear Proteins From Cultured Monkey Lacrimal Acinar Cells Free
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Atsuko Fujii; Ayumi Morimoto-Tochigi; Ryan D. Walkup; Thomas R. Shearer; Mitsuyoshi Azuma
Tags: acinar cells, bodily secretions, cercopithecidae, proteins, cytokine
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2533-2540. doi:https://doi.org/10.1167/iovs.12-10394
Effect of Growth Factors on the Proliferation and Gene Expression of Human Meibomian Gland Epithelial Cells Free
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Shaohui Liu; Wendy R. Kam; Juan Ding; Mark P. Hatton; David A. Sullivan
Tags: epithelial cells, growth factor, meibomian gland, gene expression, lipids
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2541-2550. doi:https://doi.org/10.1167/iovs.12-11221
Effects of Keratin and Lung Surfactant Proteins on the Surface Activity of Meibomian Lipids Free
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Chendur K. Palaniappan; Burkhardt S. Schütt; Lars Bräuer; Martin Schicht; Thomas J. Millar
Tags: keratins, lipids, proteins, pulmonary surfactants, small patella syndrome
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2571-2581. doi:https://doi.org/10.1167/iovs.12-11084
Quantitative Analysis of Tear Film Fluorescence and Discomfort During Tear Film Instability and Thinning Free
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Carolyn Begley; Trefford Simpson; Haixia Liu; Eliza Salvo; Ziwei Wu; Arthur Bradley; Ping Situ
Tags: fluorescence, tear film finding, cornea, pixel, eye
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2645-2653. doi:https://doi.org/10.1167/iovs.12-11299
Ocular Inflammation and Corneal Permeability Alteration by Benzalkonium Chloride in Rats: A Protective Effect of a Myosin Light Chain Kinase Inhibitor Free
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Marie Thérèse Droy-Lefaix; Lionel Bueno; Philippe Caron; Eric Belot; Olivier Roche
Tags: benzalkonium chloride, cornea, eye inflammation, myosin light chain kinase, permeability
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2705-2710. doi:https://doi.org/10.1167/iovs.12-10193
Structural and Rheological Properties of Meibomian Lipid Free
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Liat Rosenfeld; Colin Cerretani; Danielle L. Leiske; Michael F. Toney; Clayton J. Radke; Gerald G. Fuller
Tags: lipids, rheology, temperature, cattle, body temperature
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2720-2732. doi:https://doi.org/10.1167/iovs.12-10987
Protection of Human Corneal Epithelial Cells From TNF-α–Induced Disruption of Barrier Function by Rebamipide Free
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Kazuhiro Kimura; Yukiko Morita; Tomoko Orita; Junpei Haruta; Yasuhiro Takeji; Koh-Hei Sonoda
Tags: corneal epithelial cells, rebamipide, tumor necrosis factors, dry eye syndromes, cornea
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2752-2760. doi:https://doi.org/10.1167/iovs.12-11294
FIH-1/c-Kit Signaling: A Novel Contributor to Corneal Epithelial Glycogen Metabolism Free
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Han Peng; Julia Katsnelson; Wending Yang; Melissa A. Brown; Robert M. Lavker
Tags: cornea, epithelium, glycogen, glycogen metabolism, proto-oncogene protein c-kit
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2781-2786. doi:https://doi.org/10.1167/iovs.12-11512
Effect of VIP on Intracellular [Ca2+], Extracellular Regulated Kinase 1/2, and Secretion in Cultured Rat Conjunctival Goblet Cells Free
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Dayu Li; Jianwei Jiao; Marie A. Shatos; Robin R. Hodges; Darlene A. Dartt
Tags: bodily secretions, conjunctiva, glycoconjugates, goblet cells, phosphotransferases
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2872-2884. doi:https://doi.org/10.1167/iovs.12-11264
Assessment of the Impact of Keratoconus on Vision-Related Quality of Life Free
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Vijaya K. Gothwal; Shailaja P. Reddy; Asma Fathima; Seelam Bharani; Rebecca Sumalini; Deepak K. Bagga; Preeji M. Sudharman
Tags: keratoconus, quality of life, vision, questionnaires, rasch model
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2902-2910. doi:https://doi.org/10.1167/iovs.12-10783
Diverse Mediators Modulate the Chloride Ion Fluxes That Drive Lacrimal Fluid Production Free
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Shivaram Selvam; Austin K. Mircheff; Samuel C. Yiu
Tags: chloride ion, epithelium, tear production, prolactin, histamine
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2927-2933. doi:https://doi.org/10.1167/iovs.12-10202

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Automated Analysis of Binocular Alignment Using an Infrared Camera and Selective Wavelength Filter Free
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Hee Kyung Yang; Jong-Mo Seo; Jeong-Min Hwang; Kwang Gi Kim
Tags: filters, optical axis alignment, strabismus
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2733-2737. doi:https://doi.org/10.1167/iovs.12-11400
Studying the Effect of Iris Mechanics on the Pupillary Light Reflex Using Brimonidine-Induced Anisocoria Free
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Yanjun Chen; Randy H. Kardon
Tags: anisocoria, brimonidine, eye, iris physiology, pupil
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2951-2958. doi:https://doi.org/10.1167/iovs.12-10916

Genetics

A Genome-Wide Association Study of Central Corneal Thickness in Latinos Free
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Xiaoyi Gao; W. James Gauderman; Yutao Liu; Paul Marjoram; Mina Torres; Talin Haritunians; Jane Z. Kuo; Yii-Der I. Chen; R. Rand Allingham; Michael A. Hauser; Kent D. Taylor; Jerome I. Rotter; Rohit Varma
Tags: cornea, genome-wide association study, hispanics or latinos, single nucleotide polymorphism, genotype
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2435-2443. doi:https://doi.org/10.1167/iovs.13-11692
Genetic Association of COL5A1 Variants in Keratoconus Patients Suggests a Complex Connection between Corneal Thinning and Keratoconus Free
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Xiaohui Li; Yelena Bykhovskaya; Ana Laura Caiado Canedo; Talin Haritunians; David Siscovick; Anthony J. Aldave; Loretta Szczotka-Flynn; Sudha K. Iyengar; Jerome I. Rotter; Kent D. Taylor; Yaron S. Rabinowitz
Tags: cornea, keratoconus, single nucleotide polymorphism, cohort studies, genetics
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2696-2704. doi:https://doi.org/10.1167/iovs.13-11601
A Genetic Variant in the SKIV2L Gene Is Significantly Associated With Age-Related Macular Degeneration in a Han Chinese Population Free
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Fang Lu; Yi Shi; Chao Qu; Peiquan Zhao; Xiaoqi Liu; Bo Gong; Shi Ma; Yu Zhou; Qi Zhang; Ping Fei; Yu Xu; Jianbin Hu; Yingchuan Fan; Ying Lin; Xianjun Zhu; Zhenglin Yang
Tags: age-related macular degeneration, chinese (other dialects), chinese people, genes, genetics
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2911-2917. doi:https://doi.org/10.1167/iovs.12-11381

Glaucoma

Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT With or Without Correction of Ocular Rotation Free
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Hiroyo Hirasawa; Makoto Araie; Atsuo Tomidokoro; Hitomi Saito; Aiko Iwase; Shinji Ohkubo; Kazuhisa Sugiyama; Tomohiro Ootani; Shoji Kishi; Kenji Matsushita; Naoyuki Maeda; Masanori Hangai; Nagahisa Yoshimura
Tags: cerebral vasospasm, chorionic villi sampling, cyclical vomiting syndrome, eye, glaucoma
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2562-2570. doi:https://doi.org/10.1167/iovs.12-10552
Innate Immune Network in the Retina Activated by Optic Nerve Crush Free
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Justin P. Templeton; Natalie E. Freeman; John M. Nickerson; Monica M. Jablonski; Tonia S. Rex; Robert W. Williams; Eldon E. Geisert
Tags: immunity, natural, optic nerve, retina, genes, mice
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2599-2606. doi:https://doi.org/10.1167/iovs.12-11175
Reflectance Speckle of Retinal Nerve Fiber Layer Reveals Axonal Activity Free
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Xiang-Run Huang; Robert W. Knighton; Ye Zhou; Xiao-Peng Zhao
Tags: retinal nerve fiber layer, retina
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2616-2623. doi:https://doi.org/10.1167/iovs.12-11347
Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation Free
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Joel R. Palko; Simone Iwabe; Xueliang Pan; Gunjan Agarwal; András M. Komáromy; Jun Liu
Tags: collagen, dog, domestic, eye, sclera, solubility
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2685-2695. doi:https://doi.org/10.1167/iovs.12-10621
Sensitivity and Specificity of Short-Duration Transient Visual Evoked Potentials (SD-tVEP) in Discriminating Normal From Glaucomatous Eyes Free
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Cinthi Pillai; Robert Ritch; Peter Derr; Alberto Gonzalez; Laurie Kopko Cox; John Siegfried; Jeffrey M. Liebmann; Celso Tello
Tags: evoked potentials, visual, eye, glaucoma, sensitivity and specificity
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2847-2852. doi:https://doi.org/10.1167/iovs.12-10097
An Ultra-High-Speed Scheimpflug Camera for Evaluation of Corneal Deformation Response and Its Impact on IOP Measurement Free
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Christopher Kai-Shun Leung; Cong Ye; Robert N. Weinreb
Tags: cornea, intraocular pressure
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2885-2892. doi:https://doi.org/10.1167/iovs.12-11563
Contribution of Different Anatomical and Physiologic Factors to Iris Contour and Anterior Chamber Angle Changes During Pupil Dilation: Theoretical Analysis Free
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Sara Jouzdani; Rouzbeh Amini; Victor H. Barocas
Tags: dilatation, pathologic, immune reconstitution inflammatory syndrome, iris, mydriasis, pupil dilation
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2977-2984. doi:https://doi.org/10.1167/iovs.12-10748
Effect of Anterior Chamber Cannulation and Acute IOP Elevation on Retinal Macrophages in the Adult Mouse Free
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Jelena M. Kezic; Vicki Chrysostomou; Ian A. Trounce; Paul G. McMenamin; Jonathan G. Crowston
Tags: catheterization, intraocular pressure, macrophages, mice, adult
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3028-3036. doi:https://doi.org/10.1167/iovs.13-11865
Comparative Phospholipid Profiles of Control and Glaucomatous Human Trabecular Meshwork Free
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Katyayini Aribindi; Yenifer Guerra; Richard K. Lee; Sanjoy K. Bhattacharya
Tags: glaucoma, lipids, phospholipids, trabecular meshwork
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3037-3044. doi:https://doi.org/10.1167/iovs.12-10517
Correlation Between the Ganglion Cell-Inner Plexiform Layer Thickness Measured With Cirrus HD-OCT and Macular Visual Field Sensitivity Measured With Microperimetry Free
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Shino Sato; Kazuyuki Hirooka; Tetsuya Baba; Kaori Tenkumo; Eri Nitta; Fumio Shiraga
Tags: ganglia, glaucoma, visual fields, eye
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3046-3051. doi:https://doi.org/10.1167/iovs.12-11173

Immunology and Microbiology

Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis Free
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Yihe Chen; Sunil K. Chauhan; Hyun Soo Lee; William Stevenson; Chris S. Schaumburg; Zahra Sadrai; Daniel R. Saban; Shilpa Kodati; Michael E. Stern; Reza Dana
Tags: cholinergic receptors, dry eye syndromes, eye, stress, t-lymphocytes
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2457-2464. doi:https://doi.org/10.1167/iovs.12-11121
Berberine Suppresses Th17 and Dendritic Cell Responses Free
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Yan Yang; Jian Qi; Qian Wang; Liping Du; Yan Zhou; Hongsong Yu; Aize Kijlstra; Peizeng Yang
Tags: berberine, cytokine, dendritic cells, donors, t-lymphocytes
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2516-2522. doi:https://doi.org/10.1167/iovs.12-11217
Development and Efficacy of a Drug-Releasing Soft Contact Lens Free
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Koji Kakisu; Toru Matsunaga; Shinichiro Kobayakawa; Takao Sato; Tetsuo Tochikubo
Tags: antibiotics, eyedrops, capillary leak syndrome, oryctolagus cuniculus, subclavian line
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2551-2561. doi:https://doi.org/10.1167/iovs.12-10614
Pseudomonas aeruginosa Small Protease (PASP), a Keratitis Virulence Factor Free
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Aihua Tang; Armando R. Caballero; Mary E. Marquart; Richard J. O'Callaghan
Tags: endopeptidases, keratitis, oryctolagus cuniculus, peptide hydrolases, pseudomonas
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2821-2828. doi:https://doi.org/10.1167/iovs.13-11788

Multidisciplinary Ophthalmic Imaging

Blood Flow of Ophthalmic Artery in Healthy Individuals Determined by Phase-Contrast Magnetic Resonance Imaging Free
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Khalid Ambarki; Per Hallberg; Gauti Jóhannesson; Christina Lindén; Laleh Zarrinkoob; Anders Wåhlin; Richard Birgander; Jan Malm; Anders Eklund
Tags: magnetic resonance imaging, ophthalmic artery, phase contrast, unit of flow rate, vascular flow
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2738-2745. doi:https://doi.org/10.1167/iovs.13-11737
The Impact of Flash Intensity on Retinal Vessel Oxygen Saturation Measurements Using Dual Wavelength Oximetry Free
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Rebekka Heitmar; Robert Peter Cubbidge
Tags: oximetry, oxygen, oxygen saturation measurement, retinal vessels
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2807-2811. doi:https://doi.org/10.1167/iovs.12-10493

Nantotechnology and Regenerative Medicine

Orbital Volume Augmentation After Injection of Human Orbital Adipose-Derived Stem Cells in Rabbits Free
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Jae Yeun Lee; Kwang Hyoung Lee; Hyun Min Shin; Kwang Hoe Chung; Gwang Il Kim; Helen Lew
Tags: oryctolagus cuniculus, stem cells, volume
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2410-2416. doi:https://doi.org/10.1167/iovs.12-11210

Physiology and Pharmacology

Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles Free
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Brian C. Gilger; Eva M. Abarca; Jacklyn H. Salmon; Samirkumar Patel
Tags: electroretinography, eye, histopathology tests, injections, intraocular pressure
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2483-2492. doi:https://doi.org/10.1167/iovs.13-11747
Spectrophotometric Retinal Oximetry in Pigs Free
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Sindri Traustason; Jens F. Kiilgaard; Robert A. Karlsson; Sveinn H. Hardarson; Einar Stefansson; Morten la Cour
Tags: oximetry, oxygen saturation measurement, suidae, oxygen, portugal
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2746-2751. doi:https://doi.org/10.1167/iovs.12-11284
Antiapoptotic Properties of α-Crystallin–Derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells Free
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Parameswaran G. Sreekumar; Paresh Chothe; Krishna K. Sharma; Rinku Baid; Uday Kompella; Christine Spee; Nandini Kannan; Christina Manh; Stephen J. Ryan; Vadivel Ganapathy; Ram Kannan; David R. Hinton
Tags: crystallins, molecular chaperones, peptides, retinal pigment cell, membrane transport proteins
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2787-2798. doi:https://doi.org/10.1167/iovs.12-11571

Retina

Tomographic Features of Macula After Successful Macular Hole Surgery Free
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Kazuyuki Nukada; Masanori Hangai; Sotaro Ooto; Munemitsu Yoshikawa; Nagahisa Yoshimura
Tags: eye, linear atrophy, macula densa, macula lutea, repair of hole of macula lutea
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2417-2428. doi:https://doi.org/10.1167/iovs.12-10838
Comparison of Drusen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging Free
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Zohar Yehoshua; Giovanni Gregori; SriniVas R. Sadda; Fernando M. Penha; Raquel Goldhardt; Muneeswar G. Nittala; Ranjith K. Konduru; William J. Feuer; Pooja Gupta; Ying Li; Philip J. Rosenfeld
Tags: color, diagnostic imaging, drusen, optical coherence tomography
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2429-2434. doi:https://doi.org/10.1167/iovs.12-11569
Multifocal ERG Recordings Under Visual Control of the Stimulated Fundus in Mice Free
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Ralf M. Dutescu; Sergej Skosyrski; Norbert Kociok; Irina Semkova; Stefan Mergler; Jenny Atorf; Antonia M. Joussen; Olaf Strauß; Jan Kremers
Tags: electroretinography, lasers, mice, optic disk, retinal diseases
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2582-2589. doi:https://doi.org/10.1167/iovs.12-11446
All-trans-Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway–Induced Cell Death Free
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Jacob E. Berchuck; Ping Yang; Brett A. Toimil; Zhe Ma; Peter Baciu; Glenn J. Jaffe
Tags: antibodies, cell death, complement pathway, alternative, retinal pigment cell, disease susceptibility
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2669-2677. doi:https://doi.org/10.1167/iovs.12-11020
Retrobulbar Structure Visualization With Enhanced Depth Imaging Optical Coherence Tomography Free
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Alessandro Invernizzi; Andrea Giani; Mario Cigada; Giovanni Staurenghi
Tags: diagnostic imaging, eye, optical coherence tomography, sclera, choroid
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2678-2684. doi:https://doi.org/10.1167/iovs.12-10786
Macular Pigment Optical Density in Young Adults of South Asian Origin Free
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Olivia Howells; Frank Eperjesi; Hannah Bartlett
Tags: asian, optics, pigment, young adult, questionnaires
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2711-2719. doi:https://doi.org/10.1167/iovs.12-10957
Pupillometer-Based Objective Chromatic Perimetry in Normal Eyes and Patients With Retinal Photoreceptor Dystrophies Free
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Alon Skaat; Ifat Sher; Andrew Kolker; Sivan Elyasiv; Elkana Rosenfeld; Mohamad Mhajna; Shlomo Melamed; Michael Belkin; Ygal Rotenstreich
Tags: eye, perimetry, photoreceptors, retinitis pigmentosa, pupil reaction
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2761-2770. doi:https://doi.org/10.1167/iovs.12-11127
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Free
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Charlotte Massoll; Wasym Mando; Shravan K. Chintala
Tags: axon, excitotoxicity, mice, proteins, rna, small interfering
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2771-2780. doi:https://doi.org/10.1167/iovs.12-10973
Relationship Between the Second Reflective Band on Optical Coherence Tomography and Multifocal Electroretinography in Age-Related Macular Degeneration Free
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Zhichao Wu; Lauren N. Ayton; Robyn H. Guymer; Chi D. Luu
Tags: age-related macular degeneration, electroretinography, optical coherence tomography
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2800-2806. doi:https://doi.org/10.1167/iovs.13-11613
Quantitative Fundus Autofluorescence in Mice: Correlation With HPLC Quantitation of RPE Lipofuscin and Measurement of Retina Outer Nuclear Layer Thickness Free
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Janet R. Sparrow; Anna Blonska; Erin Flynn; Tobias Duncker; Jonathan P. Greenberg; Roberta Secondi; Keiko Ueda; François C. Delori
Tags: fundus autofluorescence imaging, high pressure liquid chromatography procedure, lipofuscin, mice, retina
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2812-2820. doi:https://doi.org/10.1167/iovs.12-11490
Hypothermia Prevents Gliosis and Angiogenesis Development in an Experimental Model of Ischemic Proliferative Retinopathy Free
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Manuel Rey-Funes; Verónica Berta Dorfman; Mariano Esteban Ibarra; Elena Peña; Daniela Soledad Contartese; Jorge Goldstein; Juan Manuel Acosta; Ignacio M. Larráyoz; Ricardo Martínez-Murillo; Alfredo Martínez; César Fabián Loidl
Tags: angiogenesis, diabetic retinopathy, gliosis, hypothermia, induced, hypothermia, natural
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2836-2846. doi:https://doi.org/10.1167/iovs.12-11198
Mobility Experiments With Microrobots for Minimally Invasive Intraocular Surgery Free
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Franziska Ullrich; Christos Bergeles; Juho Pokki; Olgac Ergeneman; Sandro Erni; George Chatzipirpiridis; Salvador Pané; Carsten Framme; Bradley J. Nelson
Tags: eye, mobility, ophthalmologic surgical procedures, vitreous body, suidae
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2853-2863. doi:https://doi.org/10.1167/iovs.13-11825
Comparative Analysis of Repeatability of Manual and Automated Choroidal Thickness Measurements in Nonneovascular Age-Related Macular Degeneration Free
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Sieun Lee; Nader Fallah; Farzin Forooghian; Ashley Ko; Kaivon Pakzad-Vaezi; Andrew B. Merkur; Andrew W. Kirker; David A. Albiani; Mei Young; Marinko V. Sarunic; Mirza Faisal Beg
Tags: age-related macular degeneration, nonexudative, choroid, drusen, eye
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2864-2871. doi:https://doi.org/10.1167/iovs.12-11521
Repeatability and Reproducibility of Choroidal Vessel Layer Measurements in Diabetic Retinopathy Using Enhanced Depth Optical Coherence Tomography Free
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Dawn A. Sim; Pearse A. Keane; Hemal Mehta; Simon Fung; Javier Zarranz-Ventura; Marcus Fruttiger; Praveen J. Patel; Catherine A. Egan; Adnan Tufail
Tags: choroid, diabetic retinopathy, eye, optical coherence tomography, volume
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2893-2901. doi:https://doi.org/10.1167/iovs.12-11085
Measurement of Retinal Blood Flow Rate in Diabetic Rats: Disparity Between Techniques Due to Redistribution of Flow Free
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Wendy Leskova; Megan N. Watts; Patsy R. Carter; Randa S. Eshaq; Norman R. Harris
Tags: blood capillaries, blood flow rate, diabetes mellitus, fluid flow, rats
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2992-2999. doi:https://doi.org/10.1167/iovs.13-11915
Circulating Mononuclear Progenitor Cells: Differential Roles for Subpopulations in Repair of Retinal Vascular Injury Free
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Sergio Caballero; Sugata Hazra; Ashay Bhatwadekar; Sergio Li Calzi; Linda J. Paradiso; Leonard P. Miller; Lung-Ji Chang; Timothy S. Kern; Maria B. Grant
Tags: cd14 antigen, cd34 antigens, diabetes mellitus, mice, stem cells
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3000-3009. doi:https://doi.org/10.1167/iovs.12-10280
Automatic Drusen Quantification and Risk Assessment of Age-Related Macular Degeneration on Color Fundus Images Free
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Mark J. J. P. van Grinsven; Yara T. E. Lechanteur; Johannes P. H. van de Ven; Bram van Ginneken; Carel B. Hoyng; Thomas Theelen; Clara I. Sánchez
Tags: color, drusen, risk assessment, age-related macular degeneration
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3019-3027. doi:https://doi.org/10.1167/iovs.12-11449
Systemic Prostaglandin E1 to Treat Acute Central Retinal Artery Occlusion Free
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Yasuyuki Takai; Masaki Tanito; Yotaro Matsuoka; Katsunori Hara; Akihiro Ohira
Tags: alprostadil, central retinal artery occlusion
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3065-3071. doi:https://doi.org/10.1167/iovs.12-11445

Retinal Cell Biology

Pigment Epithelium-Derived Factor Is Retinal Ganglion Cell Neuroprotective and Axogenic After Optic Nerve Crush Injury Free
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Vasanthy Vigneswara; Martin Berry; Ann Logan; Zubair Ahmed
Tags: axon, crushing injuries, cyclic amp, epithelium, optic nerve
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2624-2633. doi:https://doi.org/10.1167/iovs.13-11803
DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose Free
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Qiuhua Zhang; Jena J. Steinle
Tags: apoptosis, dna, glucose, insulin-like growth factor binding protein 3, phosphorylation
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3052-3057. doi:https://doi.org/10.1167/iovs.12-11533

Translational

Optimization of Subconjunctival Biodegradable Microfilms for Sustained Drug Delivery to the Anterior Segment in a Small Animal Model Free
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Yu-Chi Liu; Yan Peng; Nyein Chan Lwin; Tina T. Wong; Subbu S. Venkatraman; Jodhbir S. Mehta
Tags: animal model, catabolism, drug delivery systems, drug release, prednisolone
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2607-2615. doi:https://doi.org/10.1167/iovs.12-11466
The Effect of Amniotic Membrane De-Epithelialization Method on its Biological Properties and Ability to Promote Limbal Epithelial Cell Culture Free
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Ting Zhang; Gary Hin-Fai Yam; Andri K. Riau; Rebekah Poh; John C. Allen; Gary S. Peh; Roger W. Beuerman; Donald T. Tan; Jodhbir S. Mehta
Tags: amnion, edetate disodium, edetic acid, epithelial cells, epithelialization
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3072-3081. doi:https://doi.org/10.1167/iovs.12-10805

Visual Psychophysics and Physiological Optics

In Vivo Chromatic Aberration in Eyes Implanted With Intraocular Lenses Free
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Pablo Pérez-Merino; Carlos Dorronsoro; Lourdes Llorente; Sonia Durán; Ignacio Jiménez-Alfaro; Susana Marcos
Tags: eye, intraocular lens implant device, image quality, astigmatism
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2654-2661. doi:https://doi.org/10.1167/iovs.13-11912
Inhibition of Defocus-Induced Myopia in Chickens Free
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Jill Woods; Sarah E. Guthrie; Nancy Keir; Sally Dillehay; Mark Tyson; Richard Griffin; Vivian Choh; Desmond Fonn; Lyndon Jones; Elizabeth Irving
Tags: chickens, eye, lens (device), lens, crystalline, myopia
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2662-2668. doi:https://doi.org/10.1167/iovs.12-10742
Optimizing Chinese Character Displays Improves Recognition and Reading Performance of Simulated Irregular Phosphene Maps Free
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Yanyu Lu; Han Kan; Jie Liu; Jing Wang; Chen Tao; Yao Chen; Qiushi Ren; Jie Hu; Xinyu Chai
Tags: accommodation phosphene, chief complaint, chinese (other dialects), maps, reading (activity)
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2918-2926. doi:https://doi.org/10.1167/iovs.12-11039
Impaired Speed Perception but Intact Luminance Contrast Perception in People With One Eye Free
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Krista R. Kelly; Sarah R. Zohar; Brenda L. Gallie; Jennifer K. E. Steeves
Tags: eye, luminance, perception, vision
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3058-3064. doi:https://doi.org/10.1167/iovs.12-11189

Clinical Trials

Treatment of Geographic Atrophy With Subconjunctival Sirolimus: Results of a Phase I/II Clinical Trial Free
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Wai T. Wong; Samuel Dresner; Farzin Forooghian; Tanya Glaser; Lauren Doss; Mei Zhou; Denise Cunningham; Katherine Shimel; Molly Harrington; Keri Hammel; Catherine A. Cukras; Frederick L. Ferris; Emily Y. Chew
Tags: atrophy, eye, rapamycin, visual acuity, follow-up
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2941-2950. doi:https://doi.org/10.1167/iovs.13-11650

Letters to the Editor

Is Impaired Emmetropization Related to Foveal Hypoplasia or Is It Specific to Albinism? Free
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Irene Gottlob
Tags: albinism, foveal hypoplasia
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 2940. doi:https://doi.org/10.1167/iovs.13-12097
Influence of the Eye-Tracking–Based Follow-Up Function in Retinal Nerve Fiber Layer Thickness Using Fourier-Domain Optical Coherence Tomography Free
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Lisanne J. Balk; Axel Petzold
Tags: eye-tracking, follow-up, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science April 2013, Vol.54, 3045. doi:https://doi.org/10.1167/iovs.13-12073
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