Volume 55 Issue 2 | IOVS

Targeting Host Pathways to Block HSV-1 at the Cornea Free

Paul R. Kinchington

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 716. doi:https://doi.org/10.1167/iovs.14-13879

Enrichment of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1)-Positive Macrophages Around Blood Vessels in the Normal Human Sclera Free

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Simona L. Schlereth; Barbara Neuser; Albert Caramoy; Rafael S. Grajewski; Konrad R. Koch; Falk Schrödl; Claus Cursiefen; Ludwig M. Heindl

Tags: cd44 antigens, lymphatic vessels, macrophages, sclera, endothelium

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 865-872. doi:https://doi.org/10.1167/iovs.13-13453

Integration of Defocus by Dual Power Fresnel Lenses Inhibits Myopia in the Mammalian Eye Free

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Sally A. McFadden; Dennis Y. Tse; Hannah E. Bowrey; Amelia J. Leotta; Carly S. Lam; Christine F. Wildsoet; Chi-Ho To

Tags: eye, lens (device), lens, crystalline, myopia

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 908-917. doi:https://doi.org/10.1167/iovs.13-11724

Anatomical Manifestations of Primary Blast Ocular Trauma Observed in a Postmortem Porcine Model Free

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Daniel Sherwood; William E. Sponsel; Brian J. Lund; Walt Gray; Richard Watson; Sylvia L. Groth; Kimberly Thoe; Randolph D. Glickman; Matthew A. Reilly

Tags: autopsy, basic local alignment search tool, eye, ocular trauma, suidae

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1124-1132. doi:https://doi.org/10.1167/iovs.13-13295

Biochemistry and Molecular Biology

Method Development for Quantification of Five Tear Proteins Using Selected Reaction Monitoring (SRM) Mass Spectrometry Free

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Simin Masoudi; Ling Zhong; Mark J. Raftery; Fiona J. Stapleton; Mark D. Willcox

Tags: mass spectrometry, peptides, proteins, spatial release from masking, mass or substance concentration per volume

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 767-775. doi:https://doi.org/10.1167/iovs.13-12777

Age-Related Changes of Cystatin C Expression and Polarized Secretion by Retinal Pigment Epithelium: Potential Age-Related Macular Degeneration Links Free

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Paul Kay; Yit C. Yang; Paul Hiscott; Donna Gray; Arvydas Maminishkis; Luminita Paraoan

Tags: bodily secretions, cystatin c measurement, age, proteins, age-related macular degeneration

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 926-934. doi:https://doi.org/10.1167/iovs.13-13239

Clinical and Epidemiologic Research

Seasonal Variations in the Progression of Myopia in Children Enrolled in the Correction of Myopia Evaluation Trial Free

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Jane Gwiazda; Li Deng; Ruth Manny; Thomas T. Norton

Tags: child, myopia, seasonal variation

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 752-758. doi:https://doi.org/10.1167/iovs.13-13029

The Clinical Spectrum of Microcystic Macular Edema Free

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Marloes C. Burggraaff; Jennifer Trieu; Willemien A. E. J. de Vries-Knoppert; Lisanne Balk; Axel Petzold

Tags: edema, age-related macular degeneration

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 952-961. doi:https://doi.org/10.1167/iovs.13-12912

Lens Power in a Population-Based Cross-Sectional Sample of Adults Aged 40 to 64 Years in the Shahroud Eye Study Free

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Rafael Iribarren; Ian G. Morgan; Hassan Hashemi; Mehdi Khabazkhoob; Mohammad Hassan Emamian; Mohammad Shariati; Akbar Fotouhi

Tags: adult, eye, lens (device), lens, crystalline, cornea

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1031-1039. doi:https://doi.org/10.1167/iovs.13-13575

Prevalence and Risk Factors of Age-Related Macular Degeneration in Korea: The Korea National Health and Nutrition Examination Survey 2010–2011 Free

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Bum-Joo Cho; Jang Won Heo; Tae Wan Kim; Jeeyun Ahn; Hum Chung

Tags: age-related macular degeneration, korea, national health and nutrition examination survey, prevalence, risk factors

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1101-1108. doi:https://doi.org/10.1167/iovs.13-13096

Cornea

Ocular Surface Symptoms in Veterans Returning From Operation Iraqi Freedom and Operation Enduring Freedom Free

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Yasha S. Modi; Qirat Qurban; Leonid Zlotcavitch; Roberto J. Echeverri; William Feuer; Hermes Florez; Anat Galor

Tags: signs and symptoms, veterans, risk factors, afghan campaign, iraq war, 2003-2011

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 650-653. doi:https://doi.org/10.1167/iovs.13-13330

Effects of Daily Irrigation on Corneal Epithelial Permeability and Adverse Events With Silicone Hydrogel Contact Lens Continuous Wear Free

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Meng C. Lin; Heather M. French; Andrew D. Graham; Timothy L. Sanders

Tags: adverse event, contact lenses, cornea, epithelium, hydrogel

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 776-783. doi:https://doi.org/10.1167/iovs.13-13508

The Suitability of Corneas Stored by Organ Culture for Penetrating Keratoplasty and Influence of Donor and Recipient Factors on 5-Year Graft Survival Free

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W. John Armitage; Mark N. A. Jones; Isaac Zambrano; Fiona Carley; Derek M. Tole

Tags: cornea, donors, graft survival, keratoplasty, penetrating, organ culture techniques

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 784-791. doi:https://doi.org/10.1167/iovs.13-13386

Development of Allele-Specific Gene-Silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I Free

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David G. Courtney; Sarah D. Atkinson; Johnny E. Moore; Eleonora Maurizi; Chiara Serafini; Graziella Pellegrini; Graeme C. Black; Forbes D. Manson; Gary H. F. Yam; Caroline J. MacEwen; Edwin H. A. Allen; W. H. Irwin McLean; C. B. Tara Moore

Tags: alleles, corneal epithelial cells, gene silencing, meretoja syndrome, pyrosequencing

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 977-985. doi:https://doi.org/10.1167/iovs.13-13279

Measurement of Difference Thresholds on the Ocular Surface Free

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Subam Basuthkar Sundar Rao; Trefford L. Simpson

Tags: contact lenses, cornea, lens (device), lens, crystalline, psychophysics

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1095-1100. doi:https://doi.org/10.1167/iovs.13-12874

A Model for Tear Film Thinning With Osmolarity and Fluorescein Free

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Richard J. Braun; Nicholas R. Gewecke; Carolyn G. Begley; P. Ewen King-Smith; Javed I. Siddique

Tags: fluorescein, mass or substance concentration per volume, mathematical model, osmolar concentration, tear film finding

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1133-1142. doi:https://doi.org/10.1167/iovs.13-12773

Objective Assessment of the Corneal Endothelium in Fuchs' Endothelial Dystrophy Free

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Jay W. McLaren; Lori A. Bachman; Katrina M. Kane; Sanjay V. Patel

Tags: cornea, corneal endothelium, endothelial cells, endothelium, fuchs' endothelial dystrophy

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1184-1190. doi:https://doi.org/10.1167/iovs.13-13041

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Retinal Ganglion Cell Dysfunction in Asymptomatic G11778A: Leber Hereditary Optic Neuropathy Free

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John Guy; William J. Feuer; Vittorio Porciatti; Joyce Schiffman; Fawzi Abukhalil; Ruth Vandenbroucke; Potyra R. Rosa; Byron L. Lam

Tags: eye, optic atrophy, hereditary, leber, pathophysiology, retinal ganglion cells, visual acuity

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 841-848. doi:https://doi.org/10.1167/iovs.13-13365

Development and Validation of an Improved Neurological Hemifield Test to Identify Chiasmal and Postchiasmal Lesions by Automated Perimetry Free

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Allison N. McCoy; Harry A. Quigley; Jiangxia Wang; Neil R. Miller; Prem S. Subramanian; Pradeep Y. Ramulu; Michael V. Boland

Tags: eye, glaucoma, perimetry, visual fields, scotoma

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1017-1023. doi:https://doi.org/10.1167/iovs.13-13702

Amblyopic Deficit Beyond the Fovea: Delayed and Variable Single-Trial ERP Response Latencies, but Unaltered Amplitudes Free

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Éva M. Bankó; Judit Körtvélyes; János Németh; Zoltán Vidnyánszky

Tags: amblyopia, fovea centralis

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1109-1117. doi:https://doi.org/10.1167/iovs.13-13507

Genetics

Disruption of the Blood–Aqueous Barrier and Lens Abnormalities in Mice Lacking Lysyl Oxidase-Like 1 (LOXL1) Free

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Janey L. Wiggs; Basil Pawlyk; Edward Connolly; Michael Adamian; Joan W. Miller; Louis R. Pasquale; Ramez I. Haddadin; Cynthia L. Grosskreutz; Douglas J. Rhee; Tiansen Li

Tags: blood-aqueous barrier, lens (device), lens, crystalline, mice, mice, knockout

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 856-864. doi:https://doi.org/10.1167/iovs.13-13033

Aberrant Expression of Long Noncoding RNAs in Early Diabetic Retinopathy Free

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Biao Yan; Zhi-Fu Tao; Xiu-Miao Li; Hui Zhang; Jin Yao; Qin Jiang

Tags: diabetes mellitus, diabetic retinopathy, mice, retina, rna, messenger

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 941-951. doi:https://doi.org/10.1167/iovs.13-13221

Mitochondrial DNA Variant Discovery in Normal-Tension Glaucoma Patients by Next-Generation Sequencing Free

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Jin Wook Jeoung; Moon-Woo Seong; Sung Sup Park; Dong Myung Kim; Seok Hwan Kim; Ki Ho Park

Tags: dna, mitochondrial, low tension glaucoma, massively-parallel genome sequencing, genes

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 986-992. doi:https://doi.org/10.1167/iovs.13-12968

Genotype–Phenotype Correlation Analysis for Three Primary Angle Closure Glaucoma-Associated Genetic Polymorphisms Free

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Xin Wei; Monisha E. Nongpiur; Mark S. de Leon; Mani Baskaran; Shamira A. Perera; Alicia C. How; Eranga N. Vithana; Chiea-Chuen Khor; Tin Aung

Tags: blindness, disease susceptibility, genotype-phenotype associations, glaucoma, polymorphism

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1143-1148. doi:https://doi.org/10.1167/iovs.13-13552

Identification of Mutations Causing Inherited Retinal Degenerations in the Israeli and Palestinian Populations Using Homozygosity Mapping Free

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Avigail Beryozkin; Lina Zelinger; Dikla Bandah-Rozenfeld; Elia Shevach; Anat Harel; Tim Storm; Michal Sagi; Dalia Eli; Saul Merin; Eyal Banin; Dror Sharon

Tags: family, genes, homozygote, mutation, retinal degeneration

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1149-1160. doi:https://doi.org/10.1167/iovs.13-13625

Glaucoma

Early Glaucoma Involves Both Deep Local, and Shallow Widespread, Retinal Nerve Fiber Damage of the Macular Region Free

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Donald C. Hood; Anastasia Slobodnick; Ali S. Raza; Carlos Gustavo de Moraes; Christopher C. Teng; Robert Ritch

Tags: eye, glaucoma, retinal nerve fiber layer, macula densa, macula lutea

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 632-649. doi:https://doi.org/10.1167/iovs.13-13130

Comparison of Three Intraocular Pressure Measurement Methods Including Biomechanical Properties of the Cornea Free

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Adrian Smedowski; Beata Weglarz; Dorota Tarnawska; Kai Kaarniranta; Edward Wylegala

Tags: cornea, intraocular pressure, tonometry

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 666-673. doi:https://doi.org/10.1167/iovs.13-13172

Evaluation of Retinal Nerve Fiber Layer Thickness and Axonal Transport 1 and 2 Weeks After 8 Hours of Acute Intraocular Pressure Elevation in Rats Free

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Carla J. Abbott; Tiffany E. Choe; Theresa A. Lusardi; Claude F. Burgoyne; Lin Wang; Brad Fortune

Tags: axonal transport, intraocular pressure, rats, retinal nerve fiber layer, biological transport

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 674-687. doi:https://doi.org/10.1167/iovs.13-12811

Structure–Function Mapping: Variability and Conviction in Tracing Retinal Nerve Fiber Bundles and Comparison to a Computational Model Free

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Jonathan Denniss; Andrew Turpin; Fumi Tanabe; Chota Matsumoto; Allison M. McKendrick

Tags: computer simulation, nerve fibers, optic disk, visual fields, clinicians

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 728-736. doi:https://doi.org/10.1167/iovs.13-13142

Circumferential Tensile Stiffness of Glaucomatous Trabecular Meshwork Free

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Lucinda J. Camras; W. Daniel Stamer; David Epstein; Pedro Gonzalez; Fan Yuan

Tags: eye, glaucoma, trabecular meshwork

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 814-823. doi:https://doi.org/10.1167/iovs.13-13091

Static Blood Flow Autoregulation in the Optic Nerve Head in Normal and Experimental Glaucoma Free

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Lin Wang; Claude F. Burgoyne; Grant Cull; Simon Thompson; Brad Fortune

Tags: eye, glaucoma, homeostasis, intraocular pressure, optic disk

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 873-880. doi:https://doi.org/10.1167/iovs.13-13716

Outflow Tract Ablation Using a Conditionally Cytotoxic Feline Immunodeficiency Viral Vector Free

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Ze Zhang; Amardeep S. Dhaliwal; Harry Tseng; James D. Kim; Joel S. Schuman; Robert N. Weinreb; Nils A. Loewen

Tags: ablation, cats, feline immunodeficiency virus, immunologic deficiency syndromes, spatial vectors

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 935-940. doi:https://doi.org/10.1167/iovs.13-12890

Coenzyme Q10 Inhibits Glutamate Excitotoxicity and Oxidative Stress–Mediated Mitochondrial Alteration in a Mouse Model of Glaucoma Free

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Dongwook Lee; Myoung Sup Shim; Keun-Young Kim; You Hyun Noh; Heemin Kim; Sang Yeop Kim; Robert N. Weinreb; Won-Kyu Ju

Tags: glaucoma, glutamate, glutamates, mice, oxidative stress

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 993-1005. doi:https://doi.org/10.1167/iovs.13-12564

AMA0076, a Novel, Locally Acting Rho Kinase Inhibitor, Potently Lowers Intraocular Pressure in New Zealand White Rabbits with Minimal Hyperemia Free

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Sarah Van de Velde; Tine Van Bergen; Davine Sijnave; Karolien Hollanders; Karolien Castermans; Olivier Defert; Dirk Leysen; Evelien Vandewalle; Lieve Moons; Ingeborg Stalmans

Tags: erythema, intraocular pressure, oryctolagus cuniculus, eye, kinase inhibitors

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1006-1016. doi:https://doi.org/10.1167/iovs.13-13157

OCT Evaluation of Neuroprotective Effects of Tafluprost on Retinal Injury After Intravitreal Injection of Endothelin-1 in the Rat Eye Free

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Atsushi Nagata; Katsumi Omachi; Tomomi Higashide; Satoshi Shirae; Atsushi Shimazaki; Masatsugu Nakamura; Naruhiro Ishida; Kazuhisa Sugiyama

Tags: endothelin-1, eye, intravitreal injections, retinal injuries, tafluprost

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1040-1047. doi:https://doi.org/10.1167/iovs.13-13056

Variations of Retinal Nerve Fiber Layer Thickness and Ganglion Cell–Inner Plexiform Layer Thickness According to the Torsion Direction of Optic Disc Free

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Kang Hoon Lee; Chan Yun Kim; Na Rae Kim

Tags: musculoskeletal torsion, function, optic disk, retinal nerve fiber layer, torsion, ganglia

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1048-1055. doi:https://doi.org/10.1167/iovs.13-12380

A Nicotinic Acetylcholine Receptor Agonist Prevents Loss of Retinal Ganglion Cells in a Glaucoma Model Free

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Kazuhiro Iwamoto; Patrick Birkholz; Austin Schipper; David Mata; David M. Linn; Cindy L. Linn

Tags: agonists, glaucoma, retina, sodium chloride, nicotinic receptors

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1078-1087. doi:https://doi.org/10.1167/iovs.13-12688

Inflammation-Related Cytokines of Aqueous Humor in Acute Primary Angle-Closure Eyes Free

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Wenbin Huang; Shida Chen; Xinbo Gao; Min Yang; Jing Zhang; Xingyi Li; Wei Wang; Minwen Zhou; Xinyu Zhang; Xiulan Zhang

Tags: aqueous humor, cytokine, eye, inflammation, cataract

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1088-1094. doi:https://doi.org/10.1167/iovs.13-13591

Automated Segmentation of Optic Nerve Head Structures With Optical Coherence Tomography Free

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Faisal A. Almobarak; Neil O'Leary; Alexandre S. C. Reis; Glen P. Sharpe; Donna M. Hutchison; Marcelo T. Nicolela; Balwantray C. Chauhan

Tags: optic disk, optical coherence tomography, glaucoma, image quality, bruch's basal membrane

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1161-1168. doi:https://doi.org/10.1167/iovs.13-13310

Immunology and Microbiology

Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis Free

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Oleg Alekseev; Kelly Donovan; Jane Azizkhan-Clifford

Tags: ataxia-telangiectasia, human herpesvirus 1, infections, phosphotransferases, keratitis

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 706-715. doi:https://doi.org/10.1167/iovs.13-13461

Antigen-Presenting Cells Are Stratified Within Normal Human Corneas and Are Rapidly Mobilized During Ex Vivo Viral Infection Free

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Jared E. Knickelbein; Kristine-Ann Buela; Robert L. Hendricks

Tags: antigen-presenting cells, body tissue, cornea, virus diseases, infections

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1118-1123. doi:https://doi.org/10.1167/iovs.13-13523

Chronic Ocular Chlamydia trachomatis Infection in Rabbits: Clinical and Histopathological Findings in the Posterior Segment Free

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Ernest V. Boiko; Alexei L. Pozniak; Dmitrii S. Maltsev; Alexei A. Suetov; Irina V. Nuralova

Tags: chlamydia trachomatis infections, conjunctiva, depression, post-stroke, eye, histopathology tests

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1176-1183. doi:https://doi.org/10.1167/iovs.13-13416

Lens

The Pupil Can Control an Artificial Lens Intuitively Free

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Jan Fliedner; Christian Heine; Georg Bretthauer; Helmut Wilhelm

Tags: lens (device), lens, crystalline, pupil, refractive power, diameter

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 759-766. doi:https://doi.org/10.1167/iovs.13-12162

Detection, Quantification, and Total Synthesis of Novel 3-Hydroxykynurenine Glucoside–Derived Metabolites Present in Human Lenses Free

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Nicholas A. Gad; Jasminka Mizdrak; David I. Pattison; Michael J. Davies; Roger J. W. Truscott; Joanne F. Jamie

Tags: burkina faso, glucosides, lens (device), lens, crystalline, metabolites

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 849-855. doi:https://doi.org/10.1167/iovs.13-13464

Cell Death and Ultrastructural Morphology of Femtosecond Laser–Assisted Anterior Capsulotomy Free

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Wolfgang J. Mayer; Oliver K. Klaproth; Marko Ostovic; Andreas Terfort; Thalia Vavaleskou; Fritz H. Hengerer; Thomas Kohnen

Tags: capsulotomy of anterior lens capsule, cell death, femtosecond pulsed lasers, language morphology, morphology

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 893-898. doi:https://doi.org/10.1167/iovs.13-13343

Multidisciplinary Ophthalmic Imaging

The Effects of Estrogen and Androgen on Tear Secretion and Matrix Metalloproteinase-2 Expression in Lacrimal Glands of Ovariectomized Rats Free

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Xiujun Song; Ping Zhao; Guiying Wang; Xia Zhao

Tags: androgens, bodily secretions, estrogen, gelatinase a, rats

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 745-751. doi:https://doi.org/10.1167/iovs.12-10457

Noninvasive Imaging of Retinal Morphology and Microvasculature in Obese Mice Using Optical Coherence Tomography and Optical Microangiography Free

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Zhongwei Zhi; Jennifer R. Chao; Tomasz Wietecha; Kelly L. Hudkins; Charles E. Alpers; Ruikang K. Wang

Tags: blood capillaries, diabetes mellitus, diagnostic imaging, language morphology, mice

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1024-1030. doi:https://doi.org/10.1167/iovs.13-12864

Nantotechnology and Regenerative Medicine

Surface-Modified Electrospun Poly(ε-Caprolactone) Scaffold With Improved Optical Transparency and Bioactivity for Damaged Ocular Surface Reconstruction Free

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Shweta Sharma; Deepika Gupta; Sujata Mohanty; Manjeet Jassal; Ashwini K. Agrawal; Radhika Tandon

Tags: optics, posterior cruciate ligament, ptsd checklist, transparency, reconstructive surgical procedures

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 899-907. doi:https://doi.org/10.1167/iovs.13-12727

Physiology and Pharmacology

Parapapillary Beta Zone in Primary School Children in Beijing: Associations With Outdoor Activity Free

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Yin Guo; Li Juan Liu; Liang Xu; Yan Yun Lv; Ping Tang; Yi Feng; Jin Qiong Zhou; Meng Meng; Jost B. Jonas

Tags: chief complaint, child, myopia, optic disk, refractive errors

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 918-925. doi:https://doi.org/10.1167/iovs.13-13502

Retina

Control of Photoreceptor Autophagy After Retinal Detachment: The Switch From Survival to Death Free

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Nicholas D. Chinskey; Qiong-Duon Zheng; David N. Zacks

Tags: autophagy, calpain, photoreceptors, retinal detachment, apoptosis

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 688-695. doi:https://doi.org/10.1167/iovs.13-12951

Quantitative Analyses of Retinal Vascular Area and Density After Different Methods to Reduce VEGF in a Rat Model of Retinopathy of Prematurity Free

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Haibo Wang; Zhihong Yang; Yanchao Jiang; John Flannery; Scott Hammond; Tal Kafri; Sai Karthik Vemuri; Bryan Jones; M. Elizabeth Hartnett

Tags: anti-vascular endothelial growth factor therapy, retinopathy of prematurity, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 737-744. doi:https://doi.org/10.1167/iovs.13-13429

OCT Minimum Intensity as a Predictor of Geographic Atrophy Enlargement Free

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Paul F. Stetson; Zohar Yehoshua; Carlos Alexandre A. Garcia Filho; Renata Portella Nunes; Giovanni Gregori; Philip J. Rosenfeld

Tags: atrophy, hypertrophy, photoreceptors, growth rate, retina

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 792-800. doi:https://doi.org/10.1167/iovs.13-13199

Digoxin-Induced Reversible Dysfunction of the Cone Photoreceptors in Monkeys Free

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Junzo Kinoshita; Noriaki Iwata; Tomofumi Kimotsuki; Mitsuya Yasuda

Tags: cercopithecidae, digoxin, electroretinography, retinal cone, luminance

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 881-892. doi:https://doi.org/10.1167/iovs.13-13296

Effect of Acute Intraocular Pressure Challenge on Rat Retinal and Cortical Function Free

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Tina I. Tsai; Bang V. Bui; Algis J. Vingrys

Tags: electroretinography, intraocular pressure, evoked potentials, visual

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1067-1077. doi:https://doi.org/10.1167/iovs.13-13003

The Association of Retinal Structure and Macular Pigment Distribution Free

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Verena Meyer zu Westrup; Martha Dietzel; Daniel Pauleikhoff; Hans-Werner Hense

Tags: eye, pigment, retina

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1169-1175. doi:https://doi.org/10.1167/iovs.13-12903

Retinal Cell Biology

Retrograde Neurotrophic Signaling in Rat Retinal Ganglion Cells Is Transmitted via the ERK5 but Not the ERK1/2 Pathway Free

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Christian van Oterendorp; Stavros Sgouris; Nils Schallner; Julia Biermann; Wolf A. Lagrèze

Tags: proteins, retina, retinal ganglion cells, signal transduction, axon

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 658-665. doi:https://doi.org/10.1167/iovs.13-12985

TWEAK/Fn14 Pathway Is a Novel Mediator of Retinal Neovascularization Free

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Hossein Ameri; Hua Liu; Rong Liu; Yonju Ha; Adriana A. Paulucci-Holthauzen; Shuqun Hu; Massoud Motamedi; Bernard F. Godley; Ronald G. Tilton; Wenbo Zhang

Tags: ischemia, retinal diseases, retinal neovascularization, tweak questionnaire

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 801-813. doi:https://doi.org/10.1167/iovs.13-12812

Targeting Müller Cell–Derived VEGF₁₆₄ to Reduce Intravitreal Neovascularization in the Rat Model of Retinopathy of Prematurity Free

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Yanchao Jiang; Haibo Wang; David Culp; Zhihong Yang; Lori Fotheringham; John Flannery; Scott Hammond; Tal Kafri; M. Elizabeth Hartnett

Tags: vascular endothelial growth factor a, vitreous neovascularization, retinopathy of prematurity

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 824-831. doi:https://doi.org/10.1167/iovs.13-13755

Translational

Ocular Pharmacokinetics of Intravitreally Administered Brimonidine and Dexamethasone in Animal Models With and Without Blood–Retinal Barrier Breakdown Free

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Jie Shen; Chandra Durairaj; Ton Lin; Yan Liu; James Burke

Tags: animal model, brimonidine, cercopithecidae, choroidal neovascularization, dexamethasone

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1056-1066. doi:https://doi.org/10.1167/iovs.13-13650

Visual Neuroscience

Electrophysiology and Optical Coherence Tomography to Evaluate Parkinson Disease Severity Free

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Elena Garcia-Martin; Diego Rodriguez-Mena; Maria Satue; Carmen Almarcegui; Isabel Dolz; Raquel Alarcia; Maria Seral; Vicente Polo; Jose M. Larrosa; Luis E. Pablo

Tags: electrophysiology, optical coherence tomography, parkinson disease, retinal nerve fiber layer, quality of life

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 696-705. doi:https://doi.org/10.1167/iovs.13-13062

Assessing Rod, Cone, and Melanopsin Contributions to Human Pupil Flicker Responses Free

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Pablo A. Barrionuevo; Nathaniel Nicandro; J. Jason McAnany; Andrew J. Zele; Paul Gamlin; Dingcai Cao

Tags: melanopsin, photopsia, pupil, pupil reaction, retinal cone

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 719-727. doi:https://doi.org/10.1167/iovs.13-13252

Visual Psychophysics and Physiological Optics

Cone Dystrophy With “Supernormal” Rod ERG: Psychophysical Testing Shows Comparable Rod and Cone Temporal Sensitivity Losses With No Gain in Rod Function Free

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Andrew Stockman; G. Bruce Henning; Michel Michaelides; Anthony T. Moore; Andrew R. Webster; Jocelyn Cammack; Caterina Ripamonti

Tags: retinal cone, rod photoreceptors, erg protein, human, electroretinography, cone dystrophy

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 832-840. doi:https://doi.org/10.1167/iovs.13-12919

Vision in Observers With Enhanced S-Cone Syndrome: An Excess of S-Cones but Connected Mainly to Conventional S-Cone Pathways Free

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Caterina Ripamonti; Jonathan Aboshiha; G. Bruce Henning; Panagiotis I. Sergouniotis; Michel Michaelides; Anthony T. Moore; Andrew R. Webster; Andrew Stockman

Tags: retinal cone

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 963-976. doi:https://doi.org/10.1167/iovs.13-12897

New Developments in Vision Research

Developing Cellular Therapies for Retinal Degenerative Diseases Free

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Kapil Bharti; Mahendra Rao; Sara Chandros Hull; David Stroncek; Brian P. Brooks; Ellen Feigal; Jan C. van Meurs; Christene A. Huang; Sheldon S. Miller

Tags: cell therapy, degenerative disorders, eye diseases, stem cells, animal model

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 1191-1202. doi:https://doi.org/10.1167/iovs.13-13481

Letters to the Editor

Determination of Dynamic Changes in the Nature and Biosynthesis of Glycome of wt and rd1 Mice Retinae by Lectin Microarray Analysis Free

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Satpal Ahuja

Tags: biosynthesis, lectin, mice, polysaccharides, transferase

Investigative Ophthalmology & Visual Science February 2014, Vol.55, 654-657. doi:https://doi.org/10.1167/iovs.13-13783

Erratum

Erratum Free

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Investigative Ophthalmology & Visual Science February 2014, Vol.55, 717. doi:https://doi.org/10.1167/iovs.12-10467a

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Investigative Ophthalmology & Visual Science February 2014, Vol.55, 718. doi:https://doi.org/10.1167/iovs.13-12798a

Erratum Free

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Investigative Ophthalmology & Visual Science February 2014, Vol.55, 962. doi:https://doi.org/10.1167/iovs.13-12888a

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