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Editorial

Changes for the Future Free
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David C. Beebe, Editor-in-Chief
Tags: fees and charges, vision, vision research, color, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6902. doi:https://doi.org/10.1167/iovs.13-13410

Anatomy and Pathology/Oncology

Gene Expression Signatures in Tree Shrew Sclera in Response to Three Myopiagenic Conditions Free
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Lin Guo; Michael R. Frost; Li He; John T. Siegwart, Jr; Thomas T. Norton
Tags: eye, gene expression, sclera, tupaiidae, genes
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6806-6819. doi:https://doi.org/10.1167/iovs.13-12551

Biochemistry and Molecular Biology

MicroRNA Signature in Wound Healing Following Excimer Laser Ablation: Role of miR-133b on TGFβ1, CTGF, SMA, and COL1A1 Expression Levels in Rabbit Corneal Fibroblasts Free
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Paulette M. Robinson; Tsai-Der Chuang; Sriniwas Sriram; Liya Pi; Xiao Ping Luo; Bryon E. Petersen; Gregory S. Schultz
Tags: ablation, connective tissue growth factor, cornea, fibroblasts, micrornas
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6944-6951. doi:https://doi.org/10.1167/iovs.13-12621
Comparative Analysis of Aqueous Humor Cytokine Levels Between Patients With Exudative Age-Related Macular Degeneration and Normal Controls Free
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Dong Min Cha; Se Joon Woo; Hye-Jung Kim; Cheolju Lee; Kyu Hyung Park
Tags: aqueous humor, cytokine, exudative age-related macular degeneration, igfbp2 protein, human, insulin-like growth factor i
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7038-7044. doi:https://doi.org/10.1167/iovs.13-12730

Clinical and Epidemiologic Research

Identification of VEGF-Independent Cytokines in Proliferative Diabetic Retinopathy Vitreous Free
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Jennifer L. Bromberg-White; Louis Glazer; Robert Downer; Kyle Furge; Elissa Boguslawski; Nicholas S. Duesbery
Tags: cytokine, vascular endothelial growth factor a, vitreous body, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6472-6480. doi:https://doi.org/10.1167/iovs.13-12518
Early Detection of Central Visual Function Decline in Cone–Rod Dystrophy by the Use of Macular Focal Cone Electroretinogram Free
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Lucia Galli-Resta; Marco Piccardi; Lucia Ziccardi; Antonello Fadda; Angelo Minnella; Dario Marangoni; Giorgio Placidi; Giovanni Resta; Benedetto Falsini
Tags: clinical diagnostic instrument, early diagnosis, electroretinography, follow-up, progressive cone-rod dystrophy
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6560-6569. doi:https://doi.org/10.1167/iovs.13-12676
Laser Scanning Tomography in the EPIC-Norfolk Eye Study: Principal Components and Associations Free
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Anthony P. Khawaja; Michelle P. Y. Chan; David C. Broadway; David F. Garway-Heath; Robert Luben; Jennifer L. Y. Yip; Shabina Hayat; Kay-Tee Khaw; Paul J. Foster
Tags: eye, lasers, optic disk, retinal nerve fiber layer, tomography
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6638-6645. doi:https://doi.org/10.1167/iovs.13-12490
Prevalence and Risk Factors for Diabetic Retinopathy: The Korea National Health and Nutrition Examination Survey 2008–2011 Free
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Donghyun Jee; Won Ki Lee; Seungbum Kang
Tags: diabetic retinopathy, korea, national health and nutrition examination survey, prevalence, risk factors
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6827-6833. doi:https://doi.org/10.1167/iovs.13-12654
Axial Length as a Factor Associated With Visual Outcome After Vitrectomy for Diabetic Macular Edema Free
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Yoshihiro Wakabayashi; Keisuke Kimura; Daisuke Muramatsu; Yoshihiko Usui; Kazuhiko Umazume; Jun Suzuki; Hiroshi Goto
Tags: diabetic macular edema, eye, postoperative care, surgical procedures, operative, visual acuity
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6834-6840. doi:https://doi.org/10.1167/iovs.13-12519
Serum Ferritin and Hemoglobin Are Independently Associated With Wider Retinal Venular Caliber: The Tromsø Study 2001–2008 Free
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Therese von Hanno; Geir Bertelsen; Ann Ragnhild Broderstad; Tom Wilsgaard; Ellisiv B. Mathiesen
Tags: diameter, hemoglobin, iron, retinal vascular caliber, serum ferritin level result
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7053-7060. doi:https://doi.org/10.1167/iovs.13-12204

Cornea

Myopia Control Using Toric Orthokeratology (TO-SEE Study) Free
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Connie Chen; Sin Wan Cheung; Pauline Cho
Tags: lens (device), myopia, orthokeratology, lens, crystalline, signing exact english
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6510-6517. doi:https://doi.org/10.1167/iovs.13-12527
Two-Photon Imaging of the Cornea Visualized in the Living Mouse Using Vital Dyes Free
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Hongmin Zhang; Liya Wang; Susu Liu; Yanting Xie; Xianming Deng; Siyu He; Junjie Zhang; Shengtao Sun; Xiaohua Li; Zhijie Li
Tags: cornea, diagnostic imaging, dyes, mice, photons
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6526-6535. doi:https://doi.org/10.1167/iovs.13-12214
TGF-β3 Stimulates Stromal Matrix Assembly by Human Corneal Keratocyte-Like Cells Free
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Dimitrios Karamichos; Celeste B. Rich; Ramin Zareian; Audrey E. K. Hutcheon; Jeffrey W. Ruberti; Vickery Trinkaus-Randall; James D. Zieske
Tags: cornea, keratocytes, collagen, polymerase chain reaction, fluorescent antibody technique
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6612-6619. doi:https://doi.org/10.1167/iovs.13-12861
CAP37 Activation of PKC Promotes Human Corneal Epithelial Cell Chemotaxis Free
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Gina L. Griffith; Robert A. Russell; Anne Kasus-Jacobi; Elangovan Thavathiru; Melva L. Gonzalez; Sreemathi Logan; H. Anne Pereira
Tags: chemotaxis, corneal epithelial cells, phosphotransferases, protein isoforms, proteins
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6712-6723. doi:https://doi.org/10.1167/iovs.13-12054
Sulforaphane Decreases Endothelial Cell Apoptosis in Fuchs Endothelial Corneal Dystrophy: A Novel Treatment Free
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Alireza Ziaei; Thore Schmedt; Yuming Chen; Ula V. Jurkunas
Tags: apoptosis, chronic exertional compartment syndrome, endothelial cells, endothelium, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6724-6734. doi:https://doi.org/10.1167/iovs.13-12699
Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor Free
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Patrick McNutt; Kaylie Tuznik; Marian Nelson; Angie Adkins; Megan Lyman; Elliot Glotfelty; James Hughes; Tracey Hamilton
Tags: cornea, endothelium, toxic effect, vapor, wounds and injuries
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6735-6744. doi:https://doi.org/10.1167/iovs.13-12402
Dietary α-Lipoic Acid Prevents UVB-Induced Corneal and Conjunctival Degeneration Through Multiple Effects Free
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Bo-Yie Chen; David Pei-Cheng Lin; Lin-Song Chang; Tzu-Ping Huang; Hsiang-Jui Liu; Chun-Pong Luk; Yu-Lun Lo; Han-Hsin Chang
Tags: conjunctiva, cornea, diet, ultraviolet b radiation, tissue degeneration
Investigative Ophthalmology & Visual Science November 2013, Vol.54, 6757-6766. doi:https://doi.org/10.1167/iovs.12-10891
Morphologic Characteristics and Proliferation of Rabbit Corneal Stromal Cells Onto Complexes of Collagen–Chitosan–Sodium Hyaluronate Under Simulated Microgravity Free
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Xiaoxia Li; Yan Yang; Qinhua Li; Ying Dai; Chan Wang; Jiansu Chen
Tags: chitosan, collagen, complex, cornea, microgravity
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6877-6885. doi:https://doi.org/10.1167/iovs.13-12709
Standardized Baseline Human Corneal Subbasal Nerve Density for Clinical Investigations With Laser-Scanning in Vivo Confocal Microscopy Free
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Marlen Parissi; Georgios Karanis; Stefan Randjelovic; Johan Germundsson; Enea Poletti; Alfredo Ruggeri; Tor Paaske Utheim; Neil Lagali
Tags: neurons, cornea, microscopy, confocal, lasers, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7091-7102. doi:https://doi.org/10.1167/iovs.13-12999
A New Human Primary Epithelial Cell Culture Model to Study Conjunctival Inflammation Free
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Laura García-Posadas; Isabel Arranz-Valsero; Antonio López-García; Laura Soriano-Romaní; Yolanda Diebold
Tags: conjunctiva, conjunctivitis, epithelial cells, fibroblasts, inflammation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7143-7152. doi:https://doi.org/10.1167/iovs.13-12866

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Horizontal Saccade Dynamics After Childhood Monocular Enucleation Free
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Esther G. González; Linda Lillakas; Alexander Lam; Brenda L. Gallie; Martin J. Steinbach
Tags: cellular enucleation, enucleation procedure, saccades, child, nose
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6463-6471. doi:https://doi.org/10.1167/iovs.13-12481
The Regional Extent of Suppression: Strabismics Versus Nonstrabismics Free
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Raiju Jacob Babu; Simon R. Clavagnier; William Bobier; Benjamin Thompson; Robert F. Hess
Tags: amblyopia, eye, visual fields, strabismus
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6585-6593. doi:https://doi.org/10.1167/iovs.12-11314
Short-Term Saccadic Adaptation in Patients With Anisometropic Amblyopia Free
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Rana Arham Raashid; Agnes M. F. Wong; Manokaraananthan Chandrakumar; Alan Blakeman; Herbert C. Goltz
Tags: amblyopia, anisometropic amblyopia, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6701-6711. doi:https://doi.org/10.1167/iovs.13-12553
Retinal Function and Neural Conduction Along the Visual Pathways in Affected and Unaffected Carriers With Leber's Hereditary Optic Neuropathy Free
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Lucia Ziccardi; Federico Sadun; Anna Maria De Negri; Piero Barboni; Giacomo Savini; Enrico Borrelli; Chiara La Morgia; Valerio Carelli; Vincenzo Parisi
Tags: evoked potentials, visual, nerve conduction function, optic atrophy, hereditary, leber, visual pathways, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6893-6901. doi:https://doi.org/10.1167/iovs.13-12894
Stimulation of Pontine Reticular Formation in Monkeys With Strabismus Free
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Mark M. G. Walton; Seiji Ono; Michael J. Mustari
Tags: cercopithecidae, eye, paramedian pontine reticular formation, strabismus, velocity
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7125-7136. doi:https://doi.org/10.1167/iovs.13-12924
Retinal Segmentation as Noninvasive Technique to Demonstrate Hyperplasia in Ataxia of Charlevoix-Saguenay Free
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Elena Garcia-Martin; Luis E. Pablo; Jose Gazulla; Ana Vela; Jose Manuel Larrosa; Vicente Polo; Marcia L. Marques; Jorge Alfaro
Tags: ataxia, hyperplasia, spastic ataxia, charlevoix-saguenay type
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7137-7142. doi:https://doi.org/10.1167/iovs.13-12726

Genetics

Functional Analysis of HSF4 Mutations Found in Patients With Autosomal Recessive Congenital Cataracts Free
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Kate Merath; Adam Ronchetti; Duska J. Sidjanin
Tags: autosomal recessive inheritance, congenital cataract, dna, mutation, proteins
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6646-6654. doi:https://doi.org/10.1167/iovs.13-12283
ABCA4 Gene Screening by Next-Generation Sequencing in a British Cohort Free
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Kaoru Fujinami; Jana Zernant; Ravinder K. Chana; Genevieve A. Wright; Kazushige Tsunoda; Yoko Ozawa; Kazuo Tsubota; Andrew R. Webster; Anthony T. Moore; Rando Allikmets; Michel Michaelides
Tags: cohort studies, genes, massively-parallel genome sequencing, screening, retinal diseases
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6662-6674. doi:https://doi.org/10.1167/iovs.13-12570
IQCB1 and PDE6B Mutations Cause Similar Early Onset Retinal Degenerations in Two Closely Related Terrier Dog Breeds Free
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Orly Goldstein; Jason G. Mezey; Peter A. Schweitzer; Adam R. Boyko; Chuan Gao; Carlos D. Bustamante; Julie Ann Jordan; Gustavo D. Aguirre; Gregory M. Acland
Tags: dog, domestic, mutation, retinal degeneration, retinitis pigmentosa, homozygote
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7005-7019. doi:https://doi.org/10.1167/iovs.13-12915

Glaucoma

Effects of TGF-β2 on Cadherins and β-Catenin in Human Trabecular Meshwork Cells Free
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Thomas Wecker; Hong Han; Juliane Börner; Franz Grehn; Günther Schlunck
Tags: cadherins, cell adhesion, n-cadherins, trabecular meshwork
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6456-6462. doi:https://doi.org/10.1167/iovs.13-12669
Dexamethasone Induces Cross-Linked Actin Networks in Trabecular Meshwork Cells Through Noncanonical Wnt Signaling Free
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Yong Yuan; Mindy K. Call; Yan Yuan; Yujin Zhang; Katy Fischesser; Chia-Yang Liu; Winston W.-Y. Kao
Tags: actins, dexamethasone, ligands, proteins, receptor tyrosine kinase-like orphan receptor 2
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6502-6509. doi:https://doi.org/10.1167/iovs.13-12447
Bleb Analysis by Using Anterior Segment Optical Coherence Tomography in Two Different Methods of Trabeculectomy Free
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Teruhiko Hamanaka; Takayasu Omata; Shinichiro Sekimoto; Takakazu Sugiyama; Yasunori Fujikoshi
Tags: blister, intraocular pressure, language morphology, morphology, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6536-6541. doi:https://doi.org/10.1167/iovs.13-12439
Patient-Related and System-Related Barriers to Glaucoma Follow-up in a County Hospital Population Free
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Bradford W. Lee; Yohko Murakami; Martin T. Duncan; Andrew A. Kao; Jehn-Yu Huang; Shan Lin; Kuldev Singh
Tags: follow-up, glaucoma, hospitals, county
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6542-6548. doi:https://doi.org/10.1167/iovs.13-12108
Myopia and Glaucoma in the South Korean Population Free
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Brian Chon; Mary Qiu; Shan C. Lin
Tags: glaucoma, korean, myopia, scotoma, visual field defects
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6570-6577. doi:https://doi.org/10.1167/iovs.13-12173
BDNF Treatment and Extended Recovery From Optic Nerve Trauma in the Cat Free
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Arthur J. Weber; Christine D. Harman
Tags: adaptive testing, brain-derived neurotrophic factor, cats, cell survival, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6594-6604. doi:https://doi.org/10.1167/iovs.13-12683
Robust and Censored Modeling and Prediction of Progression in Glaucomatous Visual Fields Free
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Susan R. Bryan; Koenraad A. Vermeer; Paul H. C. Eilers; Hans G. Lemij; Emmanuel M. E. H. Lesaffre
Tags: glaucoma, visual fields, regression analysis
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6694-6700. doi:https://doi.org/10.1167/iovs.12-11185
Cellular Fibronectin Expression in Human Trabecular Meshwork and Induction by Transforming Growth Factor-β2 Free
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Wanda E. Medina-Ortiz; Ricardo Belmares; Sandra Neubauer; Robert J. Wordinger; Abbot F. Clark
Tags: fibronectins, protein isoforms, proteins, trabecular meshwork, body tissue
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6779-6788. doi:https://doi.org/10.1167/iovs.13-12298
The Dynamic Response of Intraocular Pressure and Ocular Pulse Amplitude to Acute Hemodynamic Changes in Normal and Glaucomatous Eyes Free
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Jonathan C. Li; Vivek K. Gupta; Yuyi You; Keith W. Ng; Stuart L. Graham
Tags: eye, glaucoma, hemodynamics, intraocular pressure, ocular hypertension
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6960-6967. doi:https://doi.org/10.1167/iovs.13-12405
Difference in the Properties of Retinal Nerve Fiber Layer Defect Between Superior and Inferior Visual Field Loss in Glaucoma Free
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Jin A. Choi; Hae-Young Lopilly Park; Kyung-In Jung; Ki Hoon Hong; Chan Kee Park
Tags: glaucoma, retinal nerve fiber layer, blindness
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6982-6990. doi:https://doi.org/10.1167/iovs.13-12344
Reproducibility of SD-OCT–Based Ganglion Cell–Layer Thickness in Glaucoma Using Two Different Segmentation Algorithms Free
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Mona K. Garvin; Kyungmoo Lee; Trudy L. Burns; Michael D. Abràmoff; Milan Sonka; Young H. Kwon
Tags: ganglia, glaucoma, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6998-7004. doi:https://doi.org/10.1167/iovs.13-12131

Immunology and Microbiology

Intercellular Adhesion Molecule 1 Mediates Migration of Th1 and Th17 Cells Across Human Retinal Vascular Endothelium Free
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Arpita S. Bharadwaj; Lauren P. Schewitz-Bowers; Lai Wei; Richard W. J. Lee; Justine R. Smith
Tags: endothelium, intercellular adhesion molecule 1, th17 cells, vascular endothelium, t-lymphocytes
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6917-6925. doi:https://doi.org/10.1167/iovs.13-12058
Suppression of IL-22–Producing T Helper 22 Cells by RPE Cells via PD-L1/PD-1 Interactions Free
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Sunao Sugita; Yuko Kawazoe; Ayano Imai; Yoshihiko Usui; Masayo Takahashi; Manabu Mochizuki
Tags: interleukin-22, retinal pigment cell, t-lymphocytes, mice, uveitis
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6926-6933. doi:https://doi.org/10.1167/iovs.13-12703
Endogenous IgG Affects the Cell Biology of RPE Cells and Involves the TLR4 Pathway Free
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Na Niu; Jie Zhang; Michael A. McNutt
Tags: immunoglobulin g, toll-like receptor 4, retinal pigment cell
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7045-7052. doi:https://doi.org/10.1167/iovs.13-12531

Lens

UV-B–Induced DNA Damage and Repair in the Mouse Lens Free
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Rosana Mesa; Steven Bassnett
Tags: dna damage, lens (device), lens, crystalline, mice, ultraviolet b radiation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6789-6797. doi:https://doi.org/10.1167/iovs.13-12644
High Resolution OCT Quantitative Analysis of the Space Between the IOL and the Posterior Capsule During the Early Cataract Postoperative Period Free
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Aizhu Tao; Ping Lu; Jin Li; Yilei Shao; Jianhua Wang; Meixiao Shen; Yinying Zhao; Fan Lu
Tags: cataract, postoperative period, refractive errors, postoperative care, eye
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6991-6997. doi:https://doi.org/10.1167/iovs.13-12849
Ocular Anterior Segment Biometry and High-Order Wavefront Aberrations During Accommodation Free
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Yimin Yuan; Yilei Shao; Aizhu Tao; Meixiao Shen; Jianhua Wang; Guohua Shi; Qi Chen; Dexi Zhu; Yan Lian; Jia Qu; Yudong Zhang; Fan Lu
Tags: biometry, visual accommodation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7028-7037. doi:https://doi.org/10.1167/iovs.13-11893

Multidisciplinary Ophthalmic Imaging

Quantitative Analysis of Retinal Layer Optical Intensities on Three-Dimensional Optical Coherence Tomography Free
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Xinjian Chen; Ping Hou; Chao Jin; Weifang Zhu; Xiaohong Luo; Fei Shi; Milan Sonka; Haoyu Chen
Tags: optical coherence tomography, optics, image quality
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6846-6851. doi:https://doi.org/10.1167/iovs.13-12062
Imaging Errors in Localization of COMS-Type Plaques in Choroidal Melanoma Brachytherapy Free
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Mahdi Bayat; Azra Alizad; Rachel Tamminga; Jose S. Pulido; Mostafa Fatemi
Tags: brachytherapy, diagnostic imaging, eye, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6852-6859. doi:https://doi.org/10.1167/iovs.12-11499
Imaging Microscopic Pigment Chemistry in Conjunctival Melanocytic Lesions Using Pump-Probe Laser Microscopy Free
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Jesse W. Wilson; Lejla Vajzovic; Francisco E. Robles; Thomas J. Cummings; Prithvi Mruthyunjaya; Warren S. Warren
Tags: clinical diagnostic instrument, conjunctiva, diagnostic imaging, lasers, pigment
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6867-6876. doi:https://doi.org/10.1167/iovs.13-12432
Imaging of Vascular Wall Fine Structure in the Human Retina Using Adaptive Optics Scanning Laser Ophthalmoscopy Free
PDF
Toco Y. P. Chui; Thomas J. Gast; Stephen A. Burns
Tags: diagnostic imaging, optics, retina, scanning laser ophthalmoscopy, arteriole
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7115-7124. doi:https://doi.org/10.1167/iovs.13-13027

Physiology and Pharmacology

Delta-Opioid Receptors Attenuate TNF-α–Induced MMP-2 Secretion From Human ONH Astrocytes Free
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Naseem Akhter; Melissa Nix; Yasir Abdul; Sudha Singh; Shahid Husain
Tags: agonists, astrocytes, bodily secretions, gelatinase a, opioid analgesics
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6605-6611. doi:https://doi.org/10.1167/iovs.13-12196
Pigment Epithelium-Derived Factor Decreases Outflow Facility Free
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Morgan E. Rogers; Iris D. Navarro; Kristin M. Perkumas; Shannon M. Niere; R. Rand Allingham; Craig E. Crosson; W. Daniel Stamer
Tags: epithelium, eye, mice, perfusion, pigment
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6655-6661. doi:https://doi.org/10.1167/iovs.13-12766
GABAergic Control of Arteriolar Diameter in the Rat Retina Free
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Kevin Hinds; Kevin P. Monaghan; Bente Frølund; J. Graham McGeown; Tim M. Curtis
Tags: diameter, gamma-aminobutyric acid, retina, arteriole, gaba-b receptor
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6798-6805. doi:https://doi.org/10.1167/iovs.13-12362
Episcleral Venous Pressure and IOP Responses to Central Electrical Stimulation in the Rat Free
PDF
Clemens A. Strohmaier; Herbert A. Reitsamer; Jeffrey W. Kiel
Tags: electric stimulation, intraocular pressure, regulation, venous pressure level
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6860-6866. doi:https://doi.org/10.1167/iovs.13-12781

Retina

Vitreous Levels of Active Ocriplasmin Following Intravitreal Injection: Results of an Ascending Exposure Trial Free
PDF
Peter Stalmans; Aniz Girach
Tags: ocriplasmin, vitreous body, intravitreal injections
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6620-6627. doi:https://doi.org/10.1167/iovs.13-11811
Effects of Semaphorin 3A on Retinal Pigment Epithelial Cell Activity Free
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Yujing Bai; Wenzhen Yu; Na Han; Fei Yang; Yaoyao Sun; Lijuan Zhang; Min Zhao; Lvzhen Huang; Aiyi Zhou; Fei Wang; Xiaoxin Li
Tags: retinal pigment cell, semaphorin-3a, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6628-6637. doi:https://doi.org/10.1167/iovs.13-12625
Distinct Characteristics of Inferonasal Fundus Autofluorescence Patterns in Stargardt Disease and Retinitis Pigmentosa Free
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Tobias Duncker; Winston Lee; Stephen H. Tsang; Jonathan P. Greenberg; Jana Zernant; Rando Allikmets; Janet R. Sparrow
Tags: eye, fundus autofluorescence imaging, retinitis pigmentosa, stargardt's disease, fissure
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6820-6826. doi:https://doi.org/10.1167/iovs.13-12895
Choroidal Volume Variations During Childhood Free
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Chiara Mapelli; Laura Dell'Arti; Giulio Barteselli; Silvia Osnaghi; Elena Tabacchi; Michele Clerici; Roberto Ratiglia; Francesco Viola
Tags: child, volume, choroid
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6841-6845. doi:https://doi.org/10.1167/iovs.13-12761
Functional Characterization and Multimodal Imaging of Treatment-Naïve “Quiescent” Choroidal Neovascularization Free
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Giuseppe Querques; Mayer Srour; Nathalie Massamba; Anouk Georges; Naima Ben Moussa; Omer Rafaeli; Eric H. Souied
Tags: choroidal neovascularization, diagnostic imaging
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6886-6892. doi:https://doi.org/10.1167/iovs.13-11665
In Vivo Retinal Vascular Oxygen Tension Imaging and Fluorescein Angiography in the Mouse Model of Oxygen-Induced Retinopathy Free
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Olachi J. Mezu-Ndubuisi; Pang-yu Teng; Justin Wanek; Norman P. Blair; Felix Y. Chau; Narsa M. Reddy; J. Usha Raj; Sekhar P. Reddy; Mahnaz Shahidi
Tags: alveolar ventilation function, arterial oxygen tension, cell respiration, diagnostic imaging, fluorescein angiography
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6968-6972. doi:https://doi.org/10.1167/iovs.13-12126
Involvement of Nox2 NADPH Oxidase in Retinal Neovascularization Free
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Elsa C. Chan; Peter van Wijngaarden; Guei-Sheung Liu; Fan Jiang; Hitesh Peshavariya; Gregory J. Dusting
Tags: cybb gene, mice, retinal neovascularization, nadph oxidases, neovascularization, pathologic
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7061-7067. doi:https://doi.org/10.1167/iovs.13-12883
Macular Choroidal Thickness and Volume in Healthy Pediatric Individuals Measured by Swept-Source Optical Coherence Tomography Free
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Toshihiko Nagasawa; Yoshinori Mitamura; Takashi Katome; Kayo Shinomiya; Takeshi Naito; Daisuke Nagasato; Yukiko Shimizu; Hitoshi Tabuchi; Yoshiaki Kiuchi
Tags: optical coherence tomography, pediatrics, volume, adult
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7068-7074. doi:https://doi.org/10.1167/iovs.13-12350
Reticular Pseudodrusen in Early Age-Related Macular Degeneration Are Associated With Choroidal Thinning Free
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Aakriti Garg; Maris Oll; Suzanne Yzer; Stanley Chang; Gaetano R. Barile; John C. Merriam; Stephen H. Tsang; Srilaxmi Bearelly
Tags: age-related macular degeneration, diagnostic imaging, eye, macula densa, macula lutea
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7075-7081. doi:https://doi.org/10.1167/iovs.13-12474
Retinal Arterial and Venous Oxygen Saturation Is Altered in Diabetic Patients Free
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Bahram Khoobehi; Kim Firn; Hilary Thompson; Maria Reinoso; James Beach
Tags: diabetes mellitus, oxygen saturation measurement, trend, venous oxygen saturation, diabetic retinopathy
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7103-7106. doi:https://doi.org/10.1167/iovs.13-12723
Aurintricarboxylic Acid Inhibits Complement Activation, Membrane Attack Complex, and Choroidal Neovascularization in a Model of Macular Degeneration Free
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Erion Lipo; Siobhan M. Cashman; Rajendra Kumar-Singh
Tags: aurintricarboxylic acid, choroidal neovascularization, complement membrane attack complex, lasers, macular degeneration
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7107-7114. doi:https://doi.org/10.1167/iovs.13-12923

Retinal Cell Biology

Inhibitory Effect of MicroRNA-34a on Retinal Pigment Epithelial Cell Proliferation and Migration Free
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Qiang Hou; Jiang Tang; Zhenlian Wang; Chao Wang; Xiaogang Chen; Ling Hou; Xiang Da Dong; LiLi Tu
Tags: met gene, micrornas, retinal pigment cell, cell cycle, molecule
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6481-6488. doi:https://doi.org/10.1167/iovs.13-11873
Complement Factor C3a Alters Proteasome Function in Human RPE Cells and in an Animal Model of Age-Related RPE Degeneration Free
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J. Emanuel Ramos de Carvalho; Ingeborg Klaassen; Ilse M. C. Vogels; Sabine Schipper-Krom; Cornelis J. F. van Noorden; Eric Reits; Theo G. M. F. Gorgels; Arthur A. B. Bergen; Reinier O. Schlingemann
Tags: complement system proteins, multicatalytic endopeptidase complex, retinal pigment cell, tissue degeneration
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6489-6501. doi:https://doi.org/10.1167/iovs.13-12374
Effects of High Glucose-Induced Cx43 Downregulation on Occludin and ZO-1 Expression and Tight Junction Barrier Function in Retinal Endothelial Cells Free
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Thomas Tien; Kevin F. Barrette; Argyrios Chronopoulos; Sayon Roy
Tags: connexin 43, down-regulation, tight junctions, glucose, endothelial cells
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6518-6525. doi:https://doi.org/10.1167/iovs.13-11763
Laser Capture Microdissection-Directed Profiling of Glycolytic and mTOR Pathways in Areas of Selectively Ablated Müller Cells in the Murine Retina Free
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Sook Hyun Chung; Weiyong Shen; Mark C. Gillies
Tags: ablation, lasers, microdissection, mtor serine-threonine kinases, photoreceptors
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6578-6584. doi:https://doi.org/10.1167/iovs.13-12311
Identification of Vascular Endothelial Side Population Cells in the Choroidal Vessels and Their Potential Role in Age-Related Macular Degeneration Free
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Taku Wakabayashi; Hisamichi Naito; Kazuhiro Takara; Hiroyasu Kidoya; Susumu Sakimoto; Yusuke Oshima; Kohji Nishida; Nobuyuki Takakura
Tags: age-related macular degeneration, brain, choroid, choroidal neovascularization, electroconvulsive therapy
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6686-6693. doi:https://doi.org/10.1167/iovs.13-12342
Functional Analysis of Serially Expanded Human iPS Cell-Derived RPE Cultures Free
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Ruchira Singh; M. Joseph Phillips; David Kuai; Jackelyn Meyer; Jessica M. Martin; Molly A. Smith; Enio T. Perez; Wei Shen; Kyle A. Wallace; Elizabeth E. Capowski; Lynda S. Wright; David M. Gamm
Tags: aging, bodily secretions, calcium, fetus, genes
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6767-6778. doi:https://doi.org/10.1167/iovs.13-11943
Apoptotic Photoreceptor Loss and Altered Expression of Lysosomal Proteins in the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis Free
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Udo Bartsch; Giovanna Galliciotti; Guillermo F. Jofre; Wanda Jankowiak; Christian Hagel; Thomas Braulke
Tags: mice, neuronal ceroid-lipofuscinoses, photoreceptors, proteins, cathepsin d
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6952-6959. doi:https://doi.org/10.1167/iovs.13-12945
The Role of the NFAT Signaling Pathway in Retinal Neovascularization Free
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Colin A. Bretz; Sara Savage; Megan Capozzi; John S. Penn
Tags: inca trial, oxygen, retinal neovascularization, signal pathway, signal transduction pathways
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7020-7027. doi:https://doi.org/10.1167/iovs.13-12183
Migration of Retinal Pigment Epithelium Cells Is Regulated by Protein Kinase Cα In Vitro Free
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Suo Qiu; Zhaoxin Jiang; Zhen Huang; Xiaoqing Chen; Xiaobing Qian; Qianying Gao; Haihua Zheng
Tags: protein kinase, retinal pigment cell, retinal pigment epithelium, rna, small interfering, wound healing
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7082-7090. doi:https://doi.org/10.1167/iovs.13-12099
Orphan Receptor GPR179 Forms Macromolecular Complexes With Components of Metabotropic Signaling Cascade in Retina ON-Bipolar Neurons Free
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Cesare Orlandi; Yan Cao; Kirill A. Martemyanov
Tags: antibodies, complex, mice, neurons, retina
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7153-7161. doi:https://doi.org/10.1167/iovs.13-12907

Translational

Computational Model for Oxygen Transport and Consumption in Human Vitreous Free
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Benjamen A. Filas; Ying-Bo Shui; David C. Beebe
Tags: lens, crystalline, oxygen, oxygen transport, vitreous body, computer simulation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6549-6559. doi:https://doi.org/10.1167/iovs.13-12609
Phagocytosis of Photoreceptor Outer Segments by Transplanted Human Neural Stem Cells as a Neuroprotective Mechanism in Retinal Degeneration Free
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Nicolás Cuenca; Laura Fernández-Sánchez; Trevor J. McGill; Bin Lu; Shaomei Wang; Raymond Lund; Stephen Huhn; Alexandra Capela
Tags: neural stem cells, phagocytosis, photoreceptors, retinal degeneration, transplantation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6745-6756. doi:https://doi.org/10.1167/iovs.13-12860

Visual Neuroscience

The Age-Regulating Protein Klotho Is Vital to Sustain Retinal Function Free
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Nicholas J. Reish; Astha Maltare; Alex S. McKeown; Ann M. Laszczyk; Timothy W. Kraft; Alecia K. Gross; Gwendalyn D. King
Tags: kl gene, proteins, retina, electroretinography
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6675-6685. doi:https://doi.org/10.1167/iovs.13-12550
Ultrastructural Localization of GPR179 and the Impact of Mutant Forms on Retinal Function in CSNB1 Patients and a Mouse Model Free
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Jan Klooster; Maria M. van Genderen; Minzhong Yu; Ralph J. Florijn; Frans C. C. Riemslag; Arthur A. B. Bergen; Ronald G. Gregg; Neal S. Peachey; Maarten Kamermans
Tags: electroretinography, erg protein, human, mice, photopsia, mutation
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6973-6981. doi:https://doi.org/10.1167/iovs.13-12293

Visual Psychophysics and Physiological Optics

The Effects of Blur and Eccentric Viewing on Adult Acuity for Pediatric Tests: Implications for Amblyopia Detection Free
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Monika A. Formankiewicz; Sarah J. Waugh
Tags: adult, amblyopia, crowding, visual acuity, pediatrics
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6934-6943. doi:https://doi.org/10.1167/iovs.13-12543

Review

Exploiting mTOR Signaling: A Novel Translatable Treatment Strategy for Traumatic Optic Neuropathy? Free
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Peter J. Morgan-Warren; Martin Berry; Zubair Ahmed; Robert A. H. Scott; Ann Logan
Tags: axon, mtor serine-threonine kinases, signal transduction, optic nerve injuries, 1-phosphatidylinositol 3-kinase
Investigative Ophthalmology & Visual Science October 2013, Vol.54, 6903-6916. doi:https://doi.org/10.1167/iovs.13-12803

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science October 2013, Vol.54, 7162. doi:https://doi.org/10.1167/iovs.13-12159a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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