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Research Highlight

Targeting Endostatin to Potentially Prevent Retinal Neovascularization Using a Hypoxia-Responsive Müller Glia Cell–Specific Gene Therapy Free
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Cheryl Mae Craft
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8054. doi:https://doi.org/10.1167/iovs.14-15996
Delayed Vision Loss and Therapeutic Intervention After Blast Injury Free
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Tonia S. Rex
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8342. doi:https://doi.org/10.1167/iovs.14-16135
Heritability of Corneal Shape in Twin Study Free
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Renato Ambrósio, Jr
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8365. doi:https://doi.org/10.1167/iovs.14-16115
Potential Benefits of Mathematical Models to Predict Endothelial Cell Density Following Penetrating Keratoplasty Free
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Perry S. Binder
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8416. doi:https://doi.org/10.1167/iovs.14-16077
ALSPAC Study Does Not Support a Role for Vitamin D in the Prevention of Myopia Free
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Ian G. Morgan; Kathryn A. Rose
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8559. doi:https://doi.org/10.1167/iovs.14-15998

Anatomy and Pathology/Oncology

Human Eye Development Is Characterized by Coordinated Expression of Fibrillin Isoforms Free
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Dirk Hubmacher; Dieter P. Reinhardt; Thomas Plesec; Katja Schenke-Layland; Suneel S. Apte
Tags: fibrillins, protein isoforms, eye development
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7934-7944. doi:https://doi.org/10.1167/iovs.14-15453
Benzalkonium Chloride Induces Subconjunctival Fibrosis Through the COX-2–Modulated Activation of a TGF-β1/Smad3 Signaling Pathway Free
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Caihong Huang; He Wang; Juxin Pan; Dan Zhou; Wensheng Chen; Wei Li; Yongxiong Chen; Zuguo Liu
Tags: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, chronic fatigue syndrome, cyclooxygenase-2
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8111-8122. doi:https://doi.org/10.1167/iovs.14-14504
Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in Conjunctival Squamous Cell Carcinoma Free
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Laura Asnaghi; Hind Alkatan; Alka Mahale; Maha Othman; Saeed Alwadani; Hailah Al-Hussain; Sabah Jastaneiah; Wayne Yu; Azza Maktabi; Deepak P. Edward; Charles G. Eberhart
Tags: amplification, conjunctiva, dna, squamous cell carcinoma, neoplasms
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8604-8613. doi:https://doi.org/10.1167/iovs.14-14920

Biochemistry and Molecular Biology

O-GlcNAc Modification of Transcription Factor Sp1 Mediates Hyperglycemia-Induced VEGF-A Upregulation in Retinal Cells Free
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Kelly Donovan; Oleg Alekseev; Xin Qi; William Cho; Jane Azizkhan-Clifford
Tags: hyperglycemia, transcription factor, vascular endothelial growth factor a, glucose, up-regulation (physiology)
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7862-7873. doi:https://doi.org/10.1167/iovs.14-14048
Preservation of the Structure of Enzymatically-Degraded Bovine Vitreous Using Synthetic Proteoglycan Mimics Free
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Qianru Zhang; Benjamen A. Filas; Robyn Roth; John Heuser; Nan Ma; Shaili Sharma; Alyssa Panitch; David C. Beebe; Ying-Bo Shui
Tags: cattle, proteoglycan, vitreous body, liquefaction, trypsin
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8153-8162. doi:https://doi.org/10.1167/iovs.14-14366
Preparative and Biosynthetic Insights Into pdA2E and isopdA2E, Retinal-Derived Fluorophores of Retinal Pigment Epithelial Lipofuscin Free
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Junli Zhao; Ke Yao; Qiuxia Jin; Kezhi Jiang; Jingmeng Chen; Zhe Liu; Jie Li; Yalin Wu
Tags: international organization for standardization, lipofuscin, pigment, epithelium, high pressure liquid chromatography procedure
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8241-8250. doi:https://doi.org/10.1167/iovs.14-15709
Targeted Exon Sequencing in Usher Syndrome Type I Free
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Kinga M. Bujakowska; Mark Consugar; Emily Place; Shyana Harper; Jaclyn Lena; Daniel G. Taub; Joseph White; Daniel Navarro-Gomez; Carol Weigel DiFranco; Michael H. Farkas; Xiaowu Gai; Eliot L. Berson; Eric A. Pierce
Tags: exons, genes, mutation, usher syndrome, cohort studies
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8488-8496. doi:https://doi.org/10.1167/iovs.14-15169

Clinical and Epidemiologic Research

Physical Activity and the 15-Year Incidence of Age-Related Macular Degeneration Free
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Bamini Gopinath; Gerald Liew; George Burlutsky; Paul Mitchell
Tags: age-related macular degeneration, incidence, physical activity, smoking, body mass index procedure
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7799-7803. doi:https://doi.org/10.1167/iovs.14-15575
Reappraisal of Geographic Atrophy Patterns Seen on Fundus Autofluorescence Using a Latent Class Analysis Approach Free
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Marc Biarnés; Carlos G. Forero; Luis Arias; Jordi Alonso; Jordi Monés
Tags: atrophy, fundus autofluorescence imaging
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8302-8308. doi:https://doi.org/10.1167/iovs.13-13542
High Heritability of Posterior Corneal Tomography, as Measured by Scheimpflug Imaging, in a Twin Study Free
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Omar A. Mahroo; Mohammed Oomerjee; Katie M. Williams; David P. S. O'Brart; Christopher J. Hammond
Tags: cornea, diagnostic imaging, tomography, twin studies, twins
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8359-8364. doi:https://doi.org/10.1167/iovs.14-15043
The Impact of Lack of Government-Insured Routine Eye Examinations on the Incidence of Self-Reported Glaucoma, Cataracts, and Vision Loss Free
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Christina H. Chan; Graham E. Trope; Elizabeth M. Badley; Yvonne M. Buys; Ya-Ping Jin
Tags: blindness, cataract, glaucoma, government, incidence
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8544-8549. doi:https://doi.org/10.1167/iovs.14-15361
Does Vitamin D Mediate the Protective Effects of Time Outdoors On Myopia? Findings From a Prospective Birth Cohort Free
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Jeremy A. Guggenheim; Cathy Williams; Kate Northstone; Laura D. Howe; Kate Tilling; Beate St Pourcain; George McMahon; Debbie A. Lawlor
Tags: cohort studies, myopia, refractive errors, vitamin d, birth
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8550-8558. doi:https://doi.org/10.1167/iovs.14-15839

Cornea

Expression of Insulin-Like Growth Factor 2 Receptor in Corneal Keratocytes During Differentiation and in Response to Wound Healing Free
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Richard N. Bohnsack; Debra J. Warejcka; Lingyan Wang; Stephanie R. Gillespie; Audrey M. Bernstein; Sally S. Twining; Nancy M. Dahms
Tags: cornea, insulin-like growth factor ii, wound healing, myofibroblasts, fibroblasts
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7697-7708. doi:https://doi.org/10.1167/iovs.14-15179
Transcriptome Analysis of the Human Corneal Endothelium Free
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Ricardo F. Frausto; Cynthia Wang; Anthony J. Aldave
Tags: adult, cornea, corneal endothelium, endothelium, gene expression
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7821-7830. doi:https://doi.org/10.1167/iovs.14-15021
Objective Assessment of Corneal Staining Using Digital Image Analysis Free
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Yeoun Sook Chun; Woong Bae Yoon; Kwang Gi Kim; In Ki Park
Tags: cornea, digital image analysis, erosion, color
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7896-7903. doi:https://doi.org/10.1167/iovs.14-15618
The Location- and Depth-Dependent Mechanical Response of the Human Cornea Under Shear Loading Free
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Stephen R. Sloan, Jr; Yousuf M. Khalifa; Mark R. Buckley
Tags: cornea
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7919-7924. doi:https://doi.org/10.1167/iovs.14-14997
Reconstruction of the Limbal Vasculature After Limbal-Conjunctival Autograft Transplantation in Pterygium Surgery: An Angiography Study Free
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Yong Joon Kim; Seung Hoon Yoo; Jin Kwon Chung
Tags: angiogram, conjunctiva, pterygium, reconstructive surgical procedures, surgical procedures, operative
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7925-7933. doi:https://doi.org/10.1167/iovs.14-15288
Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease Free
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Sapna Tibrewal; Yair Ivanir; Joy Sarkar; Neema Nayeb-Hashemi; Charles S. Bouchard; Eunjae Kim; Sandeep Jain
Tags: dry eye syndromes, hyperosmolality, hyperosmolar hyperglycemia, neutrophil extracellular traps, neutrophils
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7961-7969. doi:https://doi.org/10.1167/iovs.14-15332
Natural History of Corneal Nerve Morphology in Mild Neuropathy Associated With Type 1 Diabetes: Development of a Potential Measure of Diabetic Peripheral Neuropathy Free
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Cirous Dehghani; Nicola Pritchard; Katie Edwards; Dimitrios Vagenas; Anthony W. Russell; Rayaz A. Malik; Nathan Efron
Tags: cornea, diabetes mellitus, diabetes mellitus, type 1, diabetic neuropathies, neurons
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7982-7990. doi:https://doi.org/10.1167/iovs.14-15605
Horizontal Intracorneal Swirling Water Migration Indicative of Corneal Endothelial Function Free
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Tomoyuki Inoue; Takeshi Kobayashi; Saori Nakao; Yuko Hara; Takashi Suzuki; Yasuhito Hayashi; Xiaodong Zheng; Atsushi Shiraishi; Yuichi Ohashi
Tags: cornea, endothelium, water, fluorescein, fluid flow
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8006-8014. doi:https://doi.org/10.1167/iovs.14-14762
Monitoring of Strain-Dependent Responsiveness to TLR Activation in the Mouse Anterior Segment Using SD-OCT Free
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Laura Elizabeth Downie; Matthew James Stainer; Holly Rose Chinnery
Tags: cornea, corneal opacity, eye, mice, normal saline
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8189-8199. doi:https://doi.org/10.1167/iovs.14-15595
Corneal Cross-Linking in Keratoconus Using the Standard and Rapid Treatment Protocol: Differences in Demarcation Line and 12-Month Outcomes Free
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Sara Brittingham; Christoph Tappeiner; Beatrice E. Frueh
Tags: corneal collagen cross-linking, corneal topography, follow-up, keratoconus, treatment protocols
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8371-8376. doi:https://doi.org/10.1167/iovs.14-15444
Quantitative Analysis of Collagen Lamellae in the Normal and Keratoconic Human Cornea by Second Harmonic Generation Imaging Microscopy Free
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Naoyuki Morishige; Ryutaro Shin-gyou-uchi; Haruya Azumi; Hiroaki Ohta; Yukiko Morita; Naoyuki Yamada; Kazuhiro Kimura; Atsushi Takahara; Koh-Hei Sonoda
Tags: collagen, cornea, diagnostic imaging, harmonics
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8377-8385. doi:https://doi.org/10.1167/iovs.14-15348
Endothelial Approach Ultrathin Corneal Grafts Prepared by Femtosecond Laser for Descemet Stripping Endothelial Keratoplasty Free
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Yu-Chi Liu; Ericia Pei Wen Teo; Khadijah Binte Adnan; Gary Hin Fai Yam; Gary Swee Lim Peh; Donald T.-H. Tan; Jodhbir S. Mehta
Tags: descemet stripping endothelial keratoplasty, endothelium, femtosecond pulsed lasers, keratoplasty, tissue transplants
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8393-8401. doi:https://doi.org/10.1167/iovs.14-15080
A Mathematical Model to Predict Endothelial Cell Density Following Penetrating Keratoplasty With Selective Dropout From Graft Failure Free
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Tonya D. Riddlesworth; Craig Kollman; Jonathan H. Lass; Sanjay V. Patel; R. Doyle Stulting; Beth Ann Benetz; Robin L. Gal; Roy W. Beck
Tags: endothelial cells, keratoplasty, penetrating, mathematical model, tissue transplants
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8409-8415. doi:https://doi.org/10.1167/iovs.14-15683
Change of Recipient Corneal Endothelial Cells After Non-Descemet's Stripping Automated Endothelial Keratoplasty in a Rabbit Model Free
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Jen-Pin Sun; Fung-Rong Hu; Yan-Ming Chen; Hsiao-Sang Chu; Wei-Li Chen
Tags: cornea, descemet stripping endothelial keratoplasty, endothelial cells, endothelium, keratoplasty
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8467-8474. doi:https://doi.org/10.1167/iovs.13-13544
Susceptibility of Stenotrophomonas maltophilia Clinical Isolates to Antibiotics and Contact Lens Multipurpose Disinfecting Solutions Free
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Keizo Watanabe; Hua Zhu; Mark Willcox
Tags: antibiotics, antimicrobials, contact lenses, disease susceptibility, disinfection
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8475-8479. doi:https://doi.org/10.1167/iovs.14-15667
Differential Expression and Function of Survivin During the Progress of Pterygium Free
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Yu-xue Xu; Li-ying Zhang; Du-lei Zou; Zhao-sheng Liu; Xu-min Shang; Hu-ping Wu; Yueping Zhou; Hui He; Zu-guo Liu
Tags: pterygium, survivin, epithelial cells
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8480-8487. doi:https://doi.org/10.1167/iovs.14-15715

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

LHON Gene Therapy Vector Prevents Visual Loss and Optic Neuropathy Induced by G11778A Mutant Mitochondrial DNA: Biodistribution and Toxicology Profile Free
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Rajeshwari Koilkonda; Hong Yu; Venu Talla; Vittorio Porciatti; William J. Feuer; William W. Hauswirth; Vince Chiodo; Kirsten E. Erger; Sanford L. Boye; Alfred S. Lewin; Thomas J. Conlon; Lauren Renner; Martha Neuringer; Carol Detrisac; John Guy
Tags: blindness, dna, mitochondrial, gene therapy, mice, optic atrophy, hereditary, leber
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7739-7753. doi:https://doi.org/10.1167/iovs.14-15388
Effects of Strabismic Amblyopia and Strabismus Without Amblyopia on Visuomotor Behavior: III. Temporal Eye–Hand Coordination During Reaching Free
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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Manokaraananthan Chandrakumar; Agnes M. F. Wong
Tags: amblyopia, eye-hand coordination, saccades, strabismic amblyopia, strabismus
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7831-7838. doi:https://doi.org/10.1167/iovs.14-15507
Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial, Part II: Correlations and Relationship to Clinical Features Free
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OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group
Tags: edema, eye, optic disk, papilledema, pseudotumor cerebri
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8173-8179. doi:https://doi.org/10.1167/iovs.14-14961
Baseline OCT Measurements in the Idiopathic Intracranial Hypertension Treatment Trial, Part I: Quality Control, Comparisons, and Variability Free
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OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group
Tags: eye, optic disk, papilledema, pseudotumor cerebri, quality control
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8180-8188. doi:https://doi.org/10.1167/iovs.14-14960
Effects of Lowering Cerebrospinal Fluid Pressure on the Shape of the Peripapillary Retina in Intracranial Hypertension Free
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Patrick Sibony; Mark J. Kupersmith; Robert Honkanen; F. James Rohlf; Ali Torab-Parhiz
Tags: cerebrospinal fluid pressure, cerebrospinal fluid shunts, diagnostic spinal puncture, eye, intracranial hypertension
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8223-8231. doi:https://doi.org/10.1167/iovs.14-15298
Damage to the Immature Optic Radiation Causes Severe Reduction of the Retinal Nerve Fiber Layer, Resulting in Predictable Visual Field Defects Free
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Finn Lennartsson; Maria Nilsson; Olof Flodmark; Lena Jacobson
Tags: diffusion tractography, magnetic resonance imaging, optic radiation, retinal nerve fiber layer, scotoma
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8278-8288. doi:https://doi.org/10.1167/iovs.14-14913
Square Wave Jerks and Anxiety as Distinctive Biomarkers for Anorexia Nervosa Free
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Andrea Phillipou; Susan Lee Rossell; David Jonathan Castle; Caroline Gurvich; Larry Allen Abel
Tags: anorexia nervosa, anxiety, biological markers
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8366-8370. doi:https://doi.org/10.1167/iovs.14-15807
Morphometry of the Trochlear Nerve and Superior Oblique Muscle Volume in Congenital Superior Oblique Palsy Free
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Dae Seung Lee; Hee Kyung Yang; Jae Hyoung Kim; Jeong-Min Hwang
Tags: diameter, fourth cranial nerve palsy, standard operating procedure, superior oblique muscle, trochlear nerve
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8571-8575. doi:https://doi.org/10.1167/iovs.14-15323

Genetics

FoxO1 Gene Confers Genetic Predisposition to Acute Anterior Uveitis With Ankylosing Spondylitis Free
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Hongsong Yu; Yunjia Liu; Lijun Zhang; Lili Wu; Minming Zheng; Ling Cheng; Le Luo; Aize Kijlstra; Peizeng Yang
Tags: ankylosing spondylitis, genes, genetic predisposition to disease, genotype, uveitis, anterior
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7970-7974. doi:https://doi.org/10.1167/iovs.14-15460
Mutations in the ABCA3 Gene Are Associated With Cataract-Microcornea Syndrome Free
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Peng Chen; Yunhai Dai; Xiaoming Wu; Ye Wang; Shiying Sun; Jingjing Xiao; Qingyan Zhang; Liping Guan; Xiaowen Zhao; Xiaodan Hao; Renhua Wu; Lixin Xie
Tags: cataract, cataract-microcornea syndrome, genes, microcornea, mutation
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8031-8043. doi:https://doi.org/10.1167/iovs.14-14098
Pathogenic Mitochondrial DNA Mutations and Associated Clinical Features in Korean Patients With Leber's Hereditary Optic Neuropathy Free
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Hae Ri Yum; Hyojin Chae; Sun Young Shin; Yonggoo Kim; Myungshin Kim; Shin Hae Park
Tags: dna, mitochondrial, korean, mitochondrial dna mutation, mutation, optic atrophy, hereditary, leber
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8095-8101. doi:https://doi.org/10.1167/iovs.14-15311
DNA Copy Number Variants of Known Glaucoma Genes in Relation to Primary Open-Angle Glaucoma Free
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Yutao Liu; Melanie E. Garrett; Brian L. Yaspan; Jessica Cooke Bailey; Stephanie J. Loomis; Murray Brilliant; Donald L. Budenz; William G. Christen; John H. Fingert; Douglas Gaasterland; Terry Gaasterland; Jae H. Kang; Richard K. Lee; Paul Lichter; Sayoko E. Moroi; Anthony Realini; Julia E. Richards; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Douglas Vollrath; Robert Weinreb; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret A. Pericak-Vance; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs; R. Rand Allingham; Allison E. Ashley-Koch; Michael A. Hauser
Tags: copy number polymorphism, dna, genes, glaucoma, open-angle glaucoma
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8251-8258. doi:https://doi.org/10.1167/iovs.14-15712

Glaucoma

Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients Free
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Kyoung In Jung; Younhea Jung; Kyoung Tae Park; Chan Kee Park
Tags: glaucoma, cribriform plate, intraocular pressure, optic disk, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7709-7715. doi:https://doi.org/10.1167/iovs.14-13957
Regional Choroidal Blood Flow and Multifocal Electroretinography in Experimental Glaucoma in Rhesus Macaques Free
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T. Michael Nork; Charlene B. Y. Kim; Kaitlyn M. Munsey; Ryan J. Dashek; James N. Ver Hoeve
Tags: electroretinography, eye, glaucoma, vascular flow, macaca mulatta
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7786-7798. doi:https://doi.org/10.1167/iovs.14-14527
Identifying “Preperimetric” Glaucoma in Standard Automated Perimetry Visual Fields Free
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Ryo Asaoka; Aiko Iwase; Kazunori Hirasawa; Hiroshi Murata; Makoto Araie
Tags: glaucoma, perimetry, visual fields, eye
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7814-7820. doi:https://doi.org/10.1167/iovs.14-15120
Models of Glaucomatous Visual Field Loss Free
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Andrew Chen; Kouros Nouri-Mahdavi; Francisco J. Otarola; Fei Yu; Abdelmonem A. Afifi; Joseph Caprioli
Tags: glaucoma, glaucomatous visual field defect, visual fields, follow-up, regression analysis
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7881-7887. doi:https://doi.org/10.1167/iovs.14-15435
Chronic Hypertension Increases Susceptibility to Acute IOP Challenge in Rats Free
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Zheng He; Algis J. Vingrys; James A. Armitage; Christine T. Nguyen; Bang V. Bui
Tags: disease susceptibility, hypertension, hypertension, chronic, intraocular pressure, rats
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7888-7895. doi:https://doi.org/10.1167/iovs.14-15207
A Positive Association Between Intrinsically Photosensitive Retinal Ganglion Cells and Retinal Nerve Fiber Layer Thinning in Glaucoma Free
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Carolina P. B. Gracitelli; Gloria L. Duque-Chica; Ana Laura Moura; Balazs V. Nagy; Geraldine R. de Melo; Marina Roizenblatt; Paula D. Borba; Sérgio H. Teixeira; Dora F. Ventura; Augusto Paranhos, Jr
Tags: glaucoma, pupil, retinal nerve fiber layer, retinal ganglion cells
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7997-8005. doi:https://doi.org/10.1167/iovs.14-15146
Additive Diagnostic Role of Imaging in Glaucoma: Optical Coherence Tomography and Retinal Nerve Fiber Layer Photography Free
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Ko Eun Kim; Seok Hwan Kim; Sohee Oh; Jin Wook Jeoung; Min Hee Suh; Je Hyun Seo; Martha Kim; Ki Ho Park; Dong Myung Kim
Tags: glaucoma, retinal nerve fiber layer, optical coherence tomography, photography, diagnostic imaging
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8024-8030. doi:https://doi.org/10.1167/iovs.14-15237
Prediction Accuracy of a Novel Dynamic Structure–Function Model for Glaucoma Progression Free
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Rongrong Hu; Iván Marín-Franch; Lyne Racette
Tags: glaucoma, eye
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8086-8094. doi:https://doi.org/10.1167/iovs.14-14928
Variation of Laminar Depth in Normal Eyes With Age and Race Free
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Lindsay A. Rhodes; Carrie Huisingh; John Johnstone; Massimo Fazio; Brandon Smith; Mark Clark; J. Crawford Downs; Cynthia Owsley; Michael J. A. Girard; Jean Martial Mari; Christopher Girkin
Tags: continental population groups, eye, sclera, optic disk, body tissue
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8123-8133. doi:https://doi.org/10.1167/iovs.14-15251
Relationship Between Iris Surface Features and Angle Width in Asian Eyes Free
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Elizabeth Sidhartha; Monisha Esther Nongpiur; Carol Y. Cheung; Mingguang He; Tien Yin Wong; Tin Aung; Ching-Yu Cheng
Tags: asian, eye, immune reconstitution inflammatory syndrome, iris, color
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8144-8148. doi:https://doi.org/10.1167/iovs.14-15402
An Objective Evaluation of Gaze Tracking in Humphrey Perimetry and the Relation With the Reproducibility of Visual Fields: A Pilot Study in Glaucoma Free
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Yukako Ishiyama; Hiroshi Murata; Chihiro Mayama; Ryo Asaoka
Tags: gaze, glaucoma, perimetry, pilot projects, visual fields
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8149-8152. doi:https://doi.org/10.1167/iovs.14-15541
Age- and Race-Related Differences in Human Scleral Material Properties Free
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Rafael Grytz; Massimo A. Fazio; Vincent Libertiaux; Luigi Bruno; Stuart Gardiner; Christopher A. Girkin; J. Crawford Downs
Tags: collagen, continental population groups, sclera, fibril, eye
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8163-8172. doi:https://doi.org/10.1167/iovs.14-14029
Diagnostic Ability of Macular Nerve Fiber Layer Thickness Using New Segmentation Software in Glaucoma Suspects Free
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Jose M. Martinez-de-la-Casa; Pilar Cifuentes-Canorea; Clara Berrozpe; Marina Sastre; Vicente Polo; Javier Moreno-Montañes; Julian Garcia-Feijoo
Tags: glaucoma, nerve fibers, software
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8343-8348. doi:https://doi.org/10.1167/iovs.14-15501
Comparison of Kang's and Littmann's Methods of Correction for Ocular Magnification in Circumpapillary Retinal Nerve Fiber Layer Measurement Free
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Kazunori Hirasawa; Nobuyuki Shoji; Yukako Yoshii; Shota Haraguchi
Tags: magnification, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8353-8358. doi:https://doi.org/10.1167/iovs.14-15720
A New Approach to Measure Visual Field Progression in Glaucoma Patients Using Variational Bayes Linear Regression Free
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Hiroshi Murata; Makoto Araie; Ryo Asaoka
Tags: glaucoma, linear regression, visual fields
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8386-8392. doi:https://doi.org/10.1167/iovs.14-14625
Endothelial Nitric Oxide Synthase–Related Mechanotransduction Changes in Aged Porcine Angular Aqueous Plexus Cells Free
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Yuan Lei; William Daniel Stamer; Jihong Wu; Xinghuai Sun
Tags: mechanotransduction, cellular, nitric oxide synthase, suidae, shear stress, aging
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8402-8408. doi:https://doi.org/10.1167/iovs.14-14992
Appositional Angle Closure in Chinese With Primary Angle Closure and Primary Angle Closure Glaucoma After Laser Peripheral Iridotomy Free
PDF
Yu-jie Yan; Ling-ling Wu; Xin Wang; Ge-ge Xiao
Tags: angle closure glaucoma, apposition, augmentative and alternative communication, chinese (other dialects), chinese people
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8506-8512. doi:https://doi.org/10.1167/iovs.14-14426
Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model Free
PDF
Makoto Ishikawa; Takeshi Yoshitomi; Charles F. Zorumski; Yukitoshi Izumi
Tags: dutasteride, finasteride, glaucoma, neuroprotective agents, neurosteroids
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8531-8541. doi:https://doi.org/10.1167/iovs.14-15624

Immunology and Microbiology

Biological Features of Herpes Simplex Virus Type 1 Latency in Mice According to Experimental Conditions and Type of Neurones Free
PDF
Sophie Cavallero; Nicolas Huot; Laetitia Francelle; Patrick Lomonte; Thierry Naas; Marc Labetoulle
Tags: infections, mice, vaccination, human herpesvirus 1, neurons
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7761-7774. doi:https://doi.org/10.1167/iovs.14-14673
Cytokine Production and Antigen Recognition by Human Mucosal Homing Conjunctival Effector Memory CD8+ T Cells Free
PDF
Geraint P. Williams; Annette Pachnio; Heather M. Long; Saaeha Rauz; S. John Curnow
Tags: conjunctiva, cytokine, memory, mucous membrane, t-lymphocytes
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8523-8530. doi:https://doi.org/10.1167/iovs.14-15133
Epiretinal Membrane Inflammatory Cell Density Might Reflect the Activity of Proliferative Diabetic Retinopathy Free
PDF
Mojca Urbančič; Špela Štunf; Aleksandra MilutinovićŽivin; Daniel Petrovič; Mojca GlobočnikPetrovič
Tags: diabetic retinopathy, epiretinal membrane, inflammatory cells, proliferative diabetic retinopathy, volume
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8576-8582. doi:https://doi.org/10.1167/iovs.13-13634

Lens

Differential Proteomic Analyses of Cataracts From Rat Models of Type 1 and 2 Diabetes Free
PDF
Sheng Su; Fei Leng; Linan Guan; Lu Zhang; Jiajia Ge; Chao Wang; Shuo Chen; Ping Liu
Tags: cataract, crystallins, diabetes mellitus, diabetes mellitus, type 2, diabetic cataract
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7848-7861. doi:https://doi.org/10.1167/iovs.14-15175

Low Vision

Importance of Eye Position on Spatial Localization in Blind Subjects Wearing an Argus II Retinal Prosthesis Free
PDF
Norman Sabbah; Colas N. Authié; Nicolae Sanda; Saddek Mohand-Said; José-Alain Sahel; Avinoam B. Safran
Tags: eye, gaze, visual prosthesis, perception, visual search
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8259-8266. doi:https://doi.org/10.1167/iovs.14-15392
Developing an Instrumental Activities of Daily Living Tool as Part of the Low Vision Assessment of Daily Activities Protocol Free
PDF
Robert P. Finger; Shane C. McSweeney; Lil Deverell; Fleur O'Hare; Sharon A. Bentley; Chi D. Luu; Robyn H. Guymer; Lauren N. Ayton
Tags: instrumental activities of daily living, visual impairment, vision
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8458-8466. doi:https://doi.org/10.1167/iovs.14-14732

Multidisciplinary Ophthalmic Imaging

The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images Free
PDF
Ravi S. Jonnal; Omer P. Kocaoglu; Robert J. Zawadzki; Sang-Hyuck Lee; John S. Werner; Donald T. Miller
Tags: calibration, optical coherence tomography, pixel, retina, retinal cone
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7904-7918. doi:https://doi.org/10.1167/iovs.14-14907
Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy Free
PDF
Naoko Aizawa; Fumihiko Nitta; Hiroshi Kunikata; Tetsuya Sugiyama; Tsunehiko Ikeda; Makoto Araie; Toru Nakazawa
Tags: albinism, endothelin-1, hydrogen, lasers, optic disk
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7991-7996. doi:https://doi.org/10.1167/iovs.14-15373
Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries in Healthy and Vasculopathic Eyes Free
PDF
Alexander Pinhas; Moataz Razeen; Michael Dubow; Alexander Gan; Toco Y. Chui; Nishit Shah; Mitul Mehta; Ronald C. Gentile; Rishard Weitz; Joseph B. Walsh; Yusufu N. Sulai; Joseph Carroll; Alfredo Dubra; Richard B. Rosen
Tags: blood capillaries, eye, perfusion, diagnostic imaging
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8056-8066. doi:https://doi.org/10.1167/iovs.14-15136
Optical Quality in Central Serous Chorioretinopathy Free
PDF
Kyungmin Lee; Joonhong Sohn; Jong Gil Choi; Sung Kun Chung
Tags: central serous chorioretinopathy, optics, visual acuity
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8598-8603. doi:https://doi.org/10.1167/iovs.14-14679

Nantotechnology and Regenerative Medicine

Design and Characterization of an Ocular Topical Liposomal Preparation to Replenish the Lipids of the Tear Film Free
PDF
Marta Vicario-de-la-Torre; José Manuel Benítez-del-Castillo; Eva Vico; Manuel Guzmán; Beatriz de-las-Heras; Rocío Herrero-Vanrell; Irene T. Molina-Martínez
Tags: lipids, liposomes, tear film finding
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7839-7847. doi:https://doi.org/10.1167/iovs.14-14700

Physiology and Pharmacology

Shear Stress-Triggered Nitric Oxide Release From Schlemm's Canal Cells Free
PDF
Nicole E. Ashpole; Darryl R. Overby; C. Ross Ethier; W. Daniel Stamer
Tags: nitric oxide, schlemm's canal, shear stress, stress, glaucoma
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8067-8076. doi:https://doi.org/10.1167/iovs.14-14722
Role of α1-Adrenoceptor Subtypes in Pupil Dilation Studied With Gene-Targeted Mice Free
PDF
Marcin L. Kordasz; Caroline Manicam; Andreas Steege; Evgeny Goloborodko; Claudia Amato; Panagiotis Laspas; Christoph Brochhausen; Norbert Pfeiffer; Adrian Gericke
Tags: adrenergic receptor, genes, immune reconstitution inflammatory syndrome, iris, mice
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8295-8301. doi:https://doi.org/10.1167/iovs.14-15706
Quantitative Imaging of Enzymatic Vitreolysis-Induced Fiber Remodeling Free
PDF
Benjamen A. Filas; Nihar S. Shah; Qianru Zhang; Ying-Bo Shui; Spencer P. Lake; David C. Beebe
Tags: diagnostic imaging, enzymes, vitreous body, proteoglycan
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8626-8637. doi:https://doi.org/10.1167/iovs.14-15225

Retina

Variability and Repeatability of Quantitative, Fourier-Domain Optical Coherence Tomography Doppler Blood Flow in Young and Elderly Healthy Subjects Free
PDF
Faryan Tayyari; Firdaus Yusof; Michal Vymyslicky; Ou Tan; David Huang; John G. Flanagan; Christopher Hudson
Tags: older adult, optical coherence tomography, vascular flow, fluid flow
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7716-7725. doi:https://doi.org/10.1167/iovs.14-14430
Spatiotemporal Interactions in the Visual Cortex Following Paired Electrical Stimulation of the Retina Free
PDF
Rosemary Cicione; James B. Fallon; Graeme D. Rathbone; Chris E. Williams; Mohit N. Shivdasani
Tags: conditioning (psychology), electric stimulation, retina, visual cortex, visual prosthesis
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7726-7738. doi:https://doi.org/10.1167/iovs.14-14754
Foveal Contour Changes Following Surgery for Idiopathic Epiretinal Membrane Free
PDF
Nathan R. Mathews; Sergey Tarima; Do-Gyun Kim; Judy E. Kim
Tags: epiretinal membrane, eye, follow-up, surgical procedures, operative, depressive disorders
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7754-7760. doi:https://doi.org/10.1167/iovs.14-15075
Retinal and Choroidal Changes With Severe Hypertension and Their Association With Visual Outcome Free
PDF
Seong Joon Ahn; Se Joon Woo; Kyu Hyung Park
Tags: hypertension, hypertensive retinopathy, eye, visual acuity, ophthalmoscopy
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7775-7785. doi:https://doi.org/10.1167/iovs.14-14915
Efficacy of Intravitreal Injection of Aflibercept in Neovascular Age-Related Macular Degeneration With or Without Choroidal Vascular Hyperpermeability Free
PDF
Masayuki Hata; Akio Oishi; Akitaka Tsujikawa; Kenji Yamashiro; Masahiro Miyake; Sotaro Ooto; Hiroshi Tamura; Hideo Nakanishi; Ayako Takahashi; Munemitsu Yoshikawa; Nagahisa Yoshimura
Tags: aflibercept, exudative age-related macular degeneration, intravitreal injections, ranibizumab, eye
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7874-7880. doi:https://doi.org/10.1167/iovs.14-14610
CEACAM1 Confers Resistance Toward Oxygen-Induced Vessel Damage in a Mouse Model of Retinopathy of Prematurity Free
PDF
Peter Ludewig; Kai Flachsbarth; Claudia Wegscheid; Gisa Tiegs; Gisbert Richard; Christoph Wagener; Udo Bartsch; Andrea Kristina Horst
Tags: mice, oxygen, retinal neovascularization, retinopathy of prematurity, neovascularization, pathologic
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7950-7960. doi:https://doi.org/10.1167/iovs.13-13403
Development and Reliability of Retinal Arteriolar Central Light Reflex Quantification System: A New Approach for Severity Grading Free
PDF
Alauddin Bhuiyan; Carol Y. Cheung; Shaun Frost; Ecosse Lamoureux; Paul Mitchell; Yogesan Kanagasingam; Tien Y. Wong
Tags: pupil light reflex, reliability, hypertension, diameter
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7975-7981. doi:https://doi.org/10.1167/iovs.14-14125
Virtual Electrodes by Current Steering in Retinal Prostheses Free
PDF
Gerald Dumm; James B. Fallon; Chris E. Williams; Mohit N. Shivdasani
Tags: maps, visual prosthesis, implants
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8077-8085. doi:https://doi.org/10.1167/iovs.14-15391
Correlations Among Near-Infrared and Short-Wavelength Autofluorescence and Spectral-Domain Optical Coherence Tomography in Recessive Stargardt Disease Free
PDF
Tobias Duncker; Marcela Marsiglia; Winston Lee; Jana Zernant; Stephen H. Tsang; Rando Allikmets; Vivienne C. Greenstein; Janet R. Sparrow
Tags: autofluorescence, optical coherence tomography, stargardt's disease, lipofuscin, tissue degeneration
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8134-8143. doi:https://doi.org/10.1167/iovs.14-14848
Erythropoietin Exerts a Neuroprotective Function Against Glutamate Neurotoxicity in Experimental Diabetic Retina Free
PDF
Limin Gu; Hua Xu; Fang Wang; Guoxu Xu; Debasish Sinha; Juan Wang; Jing-Ying Xu; Haibin Tian; Furong Gao; Weiye Li; Lixia Lu; Jingfa Zhang; Guo-Tong Xu
Tags: diabetes mellitus, erythropoietin, glutamate, glutamates, neurotoxicity syndromes
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8208-8222. doi:https://doi.org/10.1167/iovs.14-14435
Instantaneous Flow Rate of Vitreous Cutter Probes Free
PDF
Tommaso Rossi; Giorgio Querzoli; Giampiero Angelini; Alessandro Rossi; Carlo Malvasi; Mario Iossa; Guido Ripandelli
Tags: aspirations (psychology), endotracheal aspiration, fluid flow, inspiration, pulmonary aspiration
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8289-8294. doi:https://doi.org/10.1167/iovs.14-15467
Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243 Free
PDF
Laura M. Dutca; Steven F. Stasheff; Adam Hedberg-Buenz; Danielle S. Rudd; Nikhil Batra; Frederick R. Blodi; Matthew S. Yorek; Terry Yin; Malini Shankar; Judith A. Herlein; Jacinth Naidoo; Lorraine Morlock; Noelle Williams; Randy H. Kardon; Michael G. Anderson; Andrew A. Pieper; Matthew M. Harper
Tags: basic local alignment search tool, blast injuries, physiology, traumatic brain injuries, mice
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8330-8341. doi:https://doi.org/10.1167/iovs.14-15468
Population-Based Evaluation of Retinal Nerve Fiber Layer, Retinal Ganglion Cell Layer, and Inner Plexiform Layer as a Diagnostic Tool For Glaucoma Free
PDF
Henriët Springelkamp; Kyungmoo Lee; Roger C. W. Wolfs; Gabriëlle H. S. Buitendijk; Wishal D. Ramdas; Albert Hofman; Johannes R. Vingerling; Caroline C. W. Klaver; Michael D. Abràmoff; Nomdo M. Jansonius
Tags: clinical diagnostic instrument, glaucoma, retinal ganglion cells, retinal nerve fiber layer, optic disk
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8428-8438. doi:https://doi.org/10.1167/iovs.14-15506
Quantitative Assessment of the Human Retinal Microvasculature With or Without Vascular Comorbidity Free
PDF
Priscilla E. Z. Tan; Paula K. Yu; Stephen J. Cringle; Dao-Yi Yu
Tags: blood capillaries, comorbidity, donors, eye, retina
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8439-8452. doi:https://doi.org/10.1167/iovs.14-15056
Flow Behavior of Heavy Silicone Oil During Eye Movements Free
PDF
Yau Kei Chan; Rachel L. Williams; David Wong
Tags: eye, eye movement, fluid flow, silicone oils, silicon dioxide
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8453-8457. doi:https://doi.org/10.1167/iovs.14-15439
Ocular Perfusion Pressure During Pars Plana Vitrectomy: A Pilot Study Free
PDF
Tommaso Rossi; Giorgio Querzoli; Giampiero Angelini; Alessandro Rossi; Carlo Malvasi; Mario Iossa; Guido Ripandelli
Tags: intraocular pressure, intraoperative care, mopp protocol, perfusion, pilot projects
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8497-8505. doi:https://doi.org/10.1167/iovs.14-14493
Retinal Hemorheologic Characterization of Early-Stage Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy Free
PDF
Shigeta Arichika; Akihito Uji; Tomoaki Murakami; Noriyuki Unoki; Shin Yoshitake; Yoko Dodo; Sotaro Ooto; Kazuaki Miyamoto; Nagahisa Yoshimura
Tags: diabetes mellitus, diabetic retinopathy, erythrocytes, optics, scanning laser ophthalmoscopy
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8513-8522. doi:https://doi.org/10.1167/iovs.14-15121

Retinal Cell Biology

A Hypoxia-Responsive Glial Cell–Specific Gene Therapy Vector for Targeting Retinal Neovascularization Free
PDF
Manas R. Biswal; Howard M. Prentice; C. Kathleen Dorey; Janet C. Blanks
Tags: endostatins, gene therapy, glial fibrillary acidic protein, hypoxia, neovascularization, pathologic
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8044-8053. doi:https://doi.org/10.1167/iovs.14-13932
Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-β/δ Free
PDF
Sandra Suarez; Gary W. McCollum; Colin A. Bretz; Rong Yang; Megan E. Capozzi; John S. Penn
Tags: vascular endothelial growth factor a, vascular permeability, peroxisome
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8232-8240. doi:https://doi.org/10.1167/iovs.14-14217
Endothelial TWIST1 Promotes Pathological Ocular Angiogenesis Free
PDF
Jie Li; Chi-Hsiu Liu; Ye Sun; Yan Gong; Zhongjie Fu; Lucy P. Evans; Katherine T. Tian; Aimee M. Juan; Christian G. Hurst; Akiko Mammoto; Jing Chen
Tags: angiogenesis, choroidal neovascularization, endothelial cells, lasers, mice
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8267-8277. doi:https://doi.org/10.1167/iovs.14-15623
Objective Evaluation of the Degree of Pigmentation in Human Induced Pluripotent Stem Cell–Derived RPE Free
PDF
Hiroyuki Kamao; Michiko Mandai; Shunji Wakamiya; Junko Ishida; Katsutoshi Goto; Takaaki Ono; Taiji Suda; Masayo Takahashi; Junichi Kiryu
Tags: pigmentation, pluripotent stem cells, color
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8309-8318. doi:https://doi.org/10.1167/iovs.14-14694
ATP-Induced Photoreceptor Death in a Feline Model of Retinal Degeneration Free
PDF
Felix P. Aplin; Chi D. Luu; Kirstan A. Vessey; Robyn H. Guymer; Robert K. Shepherd; Erica L. Fletcher
Tags: adaptive testing, cats, chloramphenicol o-acetyltransferase, photoreceptors, retina
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8319-8329. doi:https://doi.org/10.1167/iovs.14-15732
Proinflammatory Responses Induced by CD40 in Retinal Endothelial and Müller Cells are Inhibited by Blocking CD40-Traf2,3 or CD40-Traf6 Signaling Free
PDF
Jose-Andres C. Portillo; Isaac Schwartz; Simona Zarini; Reena Bapputty; Timothy S. Kern; Rose A. Gubitosi-Klug; Robert C. Murphy; M. Cecilia Subauste; Carlos S. Subauste
Tags: cd40 antigens, signal transduction, up-regulation (physiology), cd40 ligand, intercellular adhesion molecule 1
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8590-8597. doi:https://doi.org/10.1167/iovs.14-15340
The Role of the Hypoxia Response in Shaping Retinal Vascular
Development in the Absence of Norrin/Frizzled4 Signaling Free
PDF
Amir Rattner; Yanshu Wang; Yulian Zhou; John Williams; Jeremy Nathans
Tags: congenital progressive oculo-acoustico-cerebral degeneration, hypoxia, mice, retina, signal transduction
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8614-8625. doi:https://doi.org/10.1167/iovs.14-15693
Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium Free
PDF
Bo Yu; Pei Xu; Zhenyang Zhao; Jiyang Cai; Paul Sternberg; Yan Chen
Tags: aging, amino acids, lysosomes, mice, mtor serine-threonine kinases
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8638-8650. doi:https://doi.org/10.1167/iovs.14-14758

Visual Neuroscience

Relationship Between Transient and Steady-State Pattern Electroretinograms: Theoretical and Experimental Assessment Free
PDF
Özcan Özdamar; Jonathon Toft-Nielsen; Jorge Bohórquez; Vittorio Porciatti
Tags: electroretinography, steady state, waveforms
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8560-8570. doi:https://doi.org/10.1167/iovs.14-15685

Visual Psychophysics and Physiological Optics

Visual Contrast Detection Cannot Be Predicted From Surrogate Measures of Retinal Ganglion Cell Number and Sampling Density in Healthy Young Adults Free
PDF
Jonathan Denniss; Andrew Turpin; Allison M. McKendrick
Tags: psychometrics, retinal ganglion cells, visual contrast, young adult, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 7804-7813. doi:https://doi.org/10.1167/iovs.14-15339
Simulated Hyperopic Anisometropia and Reading, Visual Information Processing, and Reading-Related Eye Movement Performance in Children Free
PDF
Sumithira Narayanasamy; Stephen J. Vincent; Geoff P. Sampson; Joanne M. Wood
Tags: academia (organization), anisometropia, child, eye movement, reading (activity)
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8015-8023. doi:https://doi.org/10.1167/iovs.14-15347
Automated Measurement of Resolution Acuity in Infants Using Remote Eye-Tracking Free
PDF
Pete R. Jones; Sarah Kalwarowsky; Janette Atkinson; Oliver J. Braddick; Marko Nardini
Tags: eye-tracking, infant, adult
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8102-8110. doi:https://doi.org/10.1167/iovs.14-15108

Clinical Trials

A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Photostress Recovery, Glare Disability, and Chromatic Contrast Free
PDF
Billy R. Hammond; Laura M. Fletcher; Franz Roos; Jonas Wittwer; Wolfgang Schalch
Tags: disability, glare, lutein, placebos, recovery of function
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8583-8589. doi:https://doi.org/10.1167/iovs.14-15573

Lecture

Introducing Kirill A. Martemyanov, the 2014 Recipient of the Cogan Award Free
PDF
Vadim Y. Arshavsky
Tags: awards and prizes
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8200. doi:https://doi.org/10.1167/iovs.14-14819
G Protein Signaling in the Retina and Beyond: The Cogan Lecture Free
PDF
Kirill A. Martemyanov
Tags: gtp-binding proteins, retina, signal transduction
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8201-8207. doi:https://doi.org/10.1167/iovs.14-15928
Introducing Wolfgang Baehr, the 2014 Recipient of the Proctor Award Free
PDF
Samuel M. Wu
Tags: awards and prizes
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8651-8652. doi:https://doi.org/10.1167/iovs.14-16265
Membrane Protein Transport in Photoreceptors: The Function of PDEδ Free
PDF
Wolfgang Baehr
Tags: biological transport, membrane proteins, photoreceptors, proteins, transducin
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8653-8666. doi:https://doi.org/10.1167/iovs.14-16066

Letters to the Editor

Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads Free
PDF
Sarah L. Doyle; Peter Adamson; Francisco J. López; Peter Humphries; Matthew Campbell
Tags: interleukin-18, interpretation of findings
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8349-8350. doi:https://doi.org/10.1167/iovs.14-15786
Author Response: Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads Free
PDF
Hiroki Kaneko
Tags: interleukin-18, interpretation of findings
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8350-8352. doi:https://doi.org/10.1167/iovs.14-15878
Association of Focal Choroidal Excavation With Age-Related Macular Degeneration Free
PDF
Giuseppe Querques
Tags: age-related macular degeneration
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8542. doi:https://doi.org/10.1167/iovs.14-15804
Author Response: Association of Focal Choroidal Excavation With Age-Related Macular Degeneration Free
PDF
Yoshimasa Kuroda; Akitaka Tsujikawa; Nagahisa Yoshimura
Tags: age-related macular degeneration
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8543. doi:https://doi.org/10.1167/iovs.14-15991

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science December 2014, Vol.55, 8055. doi:https://doi.org/10.1167/iovs-09-5109a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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