Volume 56 Issue 3 | IOVS

Editorial

Reviewers Continue to Rise to an ‘‘Exceptional” Level Free

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David C. Beebe

Tags: ophthalmology, peer group, vision

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2116. doi:https://doi.org/10.1167/iovs.15-16840

Research Highlight

Glutathione Peroxidase 4, a Unique Antioxidant Enzyme, Plays a Role in Protecting Ocular Surface Mucosal Epithelia Free

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Yoko Ogawa

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1657. doi:https://doi.org/10.1167/iovs.15-16419

Dynamic Studies of Human Corneal Fibroblasts Free

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Andrew J. Quantock

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2091. doi:https://doi.org/10.1167/iovs.15-16836

Anatomy and Pathology/Oncology

Skewed Expression of the Genes Encoding Epigenetic Modifiers in High-Risk Uveal Melanoma Free

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Naoimh Herlihy; Mehmet Dogrusöz; T. Huibertus van Essen; J. William Harbour; Pieter A. van der Velden; Marja C. J. A. van Eggermond; Geert W. Haasnoot; Peter J. van den Elsen; Martine J. Jager

Tags: epigenetics, genes, neoplasms, uveal melanoma, methylation

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1447-1458. doi:https://doi.org/10.1167/iovs.14-15250

Cancer Stem Cell Markers in Eyelid Sebaceous Gland Carcinoma: High Expression of ALDH1, CD133, and ABCG2 Correlates With Poor Prognosis Free

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Namju Kim; Ho-Kyung Choung; Min Joung Lee; Sang In Khwarg; Ji Eun Kim

Tags: cancer stem cells, eyelid, sebaceous adenocarcinoma, neoplasm metastasis, proteins

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1813-1819. doi:https://doi.org/10.1167/iovs.14-15547

Changing Material Properties of the Tree Shrew Sclera During Minus Lens Compensation and Recovery Free

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Rafael Grytz; John T. Siegwart, Jr

Tags: collagen, lens (device), lens, crystalline, myopia, recovery of function

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2065-2078. doi:https://doi.org/10.1167/iovs.14-15352

Biochemistry and Molecular Biology

Dry Eye: A Protein Conformational Disease Free

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Mohammad Azharuddin; Jayesh Khandelwal; Himadri Datta; Anjan Kr. Dasgupta; Sufi O. Raja

Tags: dry eye syndromes, proteins

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1423-1429. doi:https://doi.org/10.1167/iovs.14-15992

Clinical and Epidemiologic Research

Risk Factors for Childhood Myopia: Findings From the NICER Study Free

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Lisa O'Donoghue; Venediktos V. Kapetanankis; Julie F. McClelland; Nicola S. Logan; Christopher G. Owen; Kathryn J. Saunders; Alicja R. Rudnicka

Tags: child, myopia, risk factors, parent

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1524-1530. doi:https://doi.org/10.1167/iovs.14-15549

Efficacy and Prognostic Factors of Response to Carbonic Anhydrase Inhibitors in Management of Cystoid Macular Edema in Retinitis Pigmentosa Free

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Gerald Liew; Anthony T. Moore; Andrew R. Webster; Michel Michaelides

Tags: acetazolamide, carbonic anhydrase inhibitors, dorzolamide, macular edema, cystoid, prognostic factors

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1531-1536. doi:https://doi.org/10.1167/iovs.14-15995

Diabetes, Cardiovascular Morbidity, and Risk of Age-Related Macular Degeneration in a Primary Care Population Free

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Zdravko P. Vassilev; Ana Ruigómez; Montse Soriano-Gabarró; Luis A. García Rodríguez

Tags: age-related macular degeneration, diabetes mellitus, diabetes mellitus, type 2, morbidity, primary health care

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1585-1592. doi:https://doi.org/10.1167/iovs.14-16271

Prevalence of Myopia in Schoolchildren in Ejina: The Gobi Desert Children Eye Study Free

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Kai Guo; Da Yong Yang; Yan Wang; Xian Rong Yang; Xin Xia Jing; Yuan Yuan Guo; Dan Zhu; Qi Sheng You; Yong Tao; Jost B. Jonas

Tags: child, eye, myopia, prevalence, refractive errors

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1769-1774. doi:https://doi.org/10.1167/iovs.14-15737

Serum Leptin and Age-Related Macular Degeneration Free

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Sudarshan Seshasai; Jiemin Liao; Qi Chun Toh; Ching-Yu Cheng; Gemmy Chui Ming Cheung; Sunil Sethi; Tien Yin Wong; Charumathi Sabanayagam

Tags: age-related macular degeneration, leptin, serum leptin measurement, smoking

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1880-1886. doi:https://doi.org/10.1167/iovs.14-15933

Normative Distribution of Visual Acuity in 3- to 6-Year-Old Chinese Preschoolers: The Shenzhen Kindergarten Eye Study Free

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Xinxing Guo; Min Fu; Juan Lü; Qixia Chen; Yangfa Zeng; Xiaohu Ding; Ian G. Morgan; Mingguang He

Tags: amblyopia, child, chinese (other dialects), chinese people, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1985-1992. doi:https://doi.org/10.1167/iovs.14-15422

Cornea

Impact of Conjunctival Folds on Central Tear Meniscus Height Free

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Heiko Pult; Britta Helen Riede-Pult

Tags: conjunctiva, nose, tear film finding, volume

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1459-1466. doi:https://doi.org/10.1167/iovs.14-15908

MicroRNA-204-5p–Mediated Regulation of SIRT1 Contributes to the Delay of Epithelial Cell Cycle Traversal in Diabetic Corneas Free

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Jing Gao; Ye Wang; Xiaowen Zhao; Peng Chen; Lixin Xie

Tags: cell cycle, cornea, corneal epithelium, diabetes mellitus, epithelial cells

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1493-1504. doi:https://doi.org/10.1167/iovs.14-15913

Rocking Media Over Ex Vivo Corneas Improves This Model and Allows the Study of the Effect of Proinflammatory Cytokines on Wound Healing Free

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Pallavi Deshpande; Ílida Ortega; Farshid Sefat; Virender S. Sangwan; Nicola Green; Frederik Claeyssens; Sheila MacNeil

Tags: body rocking, cornea, cytokine, wound healing

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1553-1561. doi:https://doi.org/10.1167/iovs.14-15308

The Effect of Resveratrol on Protecting Corneal Epithelial Cells from Cytotoxicity Caused by Moxifloxacin and Benzalkonium Chloride Free

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Tzu-Yun Tsai; Ta-Ching Chen; I-Jong Wang; Chao-Yuan Yeh; Ming-Jai Su; Ruey-Hua Chen; Tzu-Hsun Tsai; Fung-Rong Hu

Tags: antioxidants, benzalkonium chloride, bronchioloalveolar carcinoma, corneal epithelial cells, cytotoxicity

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1575-1584. doi:https://doi.org/10.1167/iovs.14-15708

Poly(ADP-Ribose) Polymerase Inhibition Improves Corneal Epithelial Innervation and Wound Healing in Diabetic Rats Free

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Yong-Soo Byun; Borami Kang; Young-Sik Yoo; Choun-Ki Joo

Tags: adenosine diphosphate ribose, cornea, diabetes mellitus, diabetes mellitus, type 2, epithelium

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1948-1955. doi:https://doi.org/10.1167/iovs.14-16259

TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy Free

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V. Vinod Mootha; Imran Hussain; Khrishen Cunnusamy; Eric Graham; Xin Gong; Sudha Neelam; Chao Xing; Ralf Kittler; W. Matthew Petroll

Tags: endothelium, hereditary corneal dystrophy, rna, rna, nuclear, trinucleotide repeats

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2003-2011. doi:https://doi.org/10.1167/iovs.14-16222

Human Conjunctival Stem Cells are Predominantly Located in the Medial Canthal and Inferior Forniceal Areas Free

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Rosalind M. K. Stewart; Carl M. Sheridan; Paul S. Hiscott; Gabriela Czanner; Stephen B. Kaye

Tags: body tissue, conjunctiva, stem cells, donors

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2021-2030. doi:https://doi.org/10.1167/iovs.14-16266

The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments Free

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Miguel Miron-Mendoza; Eric Graham; Pouriska Kivanany; Jonathan Quiring; W. Matthew Petroll

Tags: collagen, cornea, fibrin, fibroblasts, thrombin

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2079-2090. doi:https://doi.org/10.1167/iovs.15-16388

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Quick Phases of Infantile Nystagmus Show the Saccadic Inhibition Effect Free

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James J. Harrison; Petroc Sumner; Matt J. Dunn; Jonathan T. Erichsen; Tom C. A. Freeman

Tags: pathologic nystagmus, saccades, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1594-1600. doi:https://doi.org/10.1167/iovs.14-15655

Space Perception of Strabismic Observers in the Real World Environment Free

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Teng Leng Ooi; Zijiang J. He

Tags: space perception, vision disparity, gait, depth perception, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1761-1768. doi:https://doi.org/10.1167/iovs.14-15741

Up/Down Anisotropies of Vertical Saccades in Healthy Children From 6 to 10 Years of Age Free

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Chrystal Gaertner; Zoï Kapoula

Tags: child, saccades

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1901-1908. doi:https://doi.org/10.1167/iovs.14-14619

Developmental Trajectory of McGurk Effect Susceptibility in Children and Adults With Amblyopia Free

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Cindy Narinesingh; Herbert C. Goltz; Rana Arham Raashid; Agnes M. F. Wong

Tags: adult, amblyopia, child, disease susceptibility, mcgurk effect

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2107-2113. doi:https://doi.org/10.1167/iovs.14-15898

Genetics

Association Between Copy Number Variations of TLR7 and Ocular Behçet's Disease in a Chinese Han Population Free

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Jing Fang; Lu Chen; Jihong Tang; Shengping Hou; Dan Liao; Zi Ye; Chaokui Wang; Qinfeng Cao; Aize Kijlstra; Peizeng Yang

Tags: behcet syndrome, chinese people, gene dosage, genes, rna, messenger

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1517-1523. doi:https://doi.org/10.1167/iovs.14-15030

Novel FRMD7 Mutations and Genomic Rearrangement Expand the Molecular Pathogenesis of X-Linked Idiopathic Infantile Nystagmus Free

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Basamat AlMoallem; Miriam Bauwens; Sophie Walraedt; Patricia Delbeke; Julie De Zaeytijd; Philippe Kestelyn; Françoise Meire; Sandra Janssens; Caroline van Cauwenbergh; Hannah Verdin; Sally Hooghe; Prasoon Kumar Thakur; Frauke Coppieters; Kim De Leeneer; Koenraad Devriendt; Bart P. Leroy; Elfride De Baere

Tags: cohort studies, mutation, pathogenesis, pathologic nystagmus, screening

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1701-1710. doi:https://doi.org/10.1167/iovs.14-15938

Next-Generation Sequencing and Novel Variant Determination in a Cohort of 92 Familial Exudative Vitreoretinopathy Patients Free

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Jason Salvo; Vera Lyubasyuk; Mingchu Xu; Hui Wang; Feng Wang; Duy Nguyen; Keqing Wang; Hongrong Luo; Cindy Wen; Catherine Shi; Danni Lin; Kang Zhang; Rui Chen

Tags: cohort studies, familial exudative vitreoretinopathies, massively-parallel genome sequencing, mutation, genes

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1937-1946. doi:https://doi.org/10.1167/iovs.14-16065

Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure Free

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Christopher A. Girkin; Caroline M. Nievergelt; Jane Z. Kuo; Adam X. Maihofer; Carrie Huisingh; Jeffrey M. Liebmann; Radha Ayyagari; Robert N. Weinreb; Robert Ritch; Linda M. Zangwill; for the ADAGES Study Group

Tags: cornea, glaucoma, optic nerve, retinal nerve fiber layer, optic disk

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2043-2049. doi:https://doi.org/10.1167/iovs.14-15719

Glaucoma

Mitochondrial Morphology Differences and Mitophagy Deficit in Murine Glaucomatous Optic Nerve Free

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Lucy Coughlin; Richard S. Morrison; Philip J. Horner; Denise M. Inman

Tags: glaucoma, mitochondria, optic nerve, morphology, proteins

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1437-1446. doi:https://doi.org/10.1167/iovs.14-16126

Severity of Vision Loss Interacts With Word-Specific Features to Impact Out-Loud Reading in Glaucoma Free

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Priya M. Mathews; Gary S. Rubin; Michael McCloskey; Sherveen Salek; Pradeep Y. Ramulu

Tags: blindness, glaucoma, loudness, reading (activity)

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1537-1545. doi:https://doi.org/10.1167/iovs.15-15462

Estimation of the Relative Amount of Hemoglobin in the Cup and Neuroretinal Rim Using Stereoscopic Color Fundus Images Free

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Cristina Pena-Betancor; Marta Gonzalez-Hernandez; Francisco Fumero-Batista; Jose Sigut; Erica Medina-Mesa; Silvia Alayon; Manuel Gonzalez de la Rosa

Tags: color, glaucoma, hemoglobin, neuroretinal rim

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1562-1568. doi:https://doi.org/10.1167/iovs.14-15592

Estimating the True Distribution of Visual Field Progression Rates in Glaucoma Free

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Andrew J. Anderson

Tags: glaucoma, visual fields

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1603-1608. doi:https://doi.org/10.1167/iovs.14-16329

Lamina Cribrosa Microarchitecture in Normal Monkey Eyes Part 1: Methods and Initial Results Free

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Howard Lockwood; Juan Reynaud; Stuart Gardiner; Jonathan Grimm; Vincent Libertiaux; J. Crawford Downs; Hongli Yang; Claude F. Burgoyne

Tags: cercopithecidae, cribriform plate, eye, connective tissue, optic disk

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1618-1637. doi:https://doi.org/10.1167/iovs.14-15967

Shorter Scleral Spur in Eyes With Primary Open-Angle Glaucoma Free

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David L. Swain; Joseph Ho; Julia Lai; Haiyan Gong

Tags: eye, open-angle glaucoma, sclera

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1638-1648. doi:https://doi.org/10.1167/iovs.14-15593

Intereye Comparison of Cirrus OCT in Early Glaucoma Diagnosis and Detecting Photographic Retinal Nerve Fiber Layer Abnormalities Free

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Hae-Young Lopilly Park; Hye-Young Shin; Jae-Yoon Yoon; Younhea Jung; Chan Kee Park

Tags: eye, glaucoma, retinal nerve fiber layer, fundus photography, maps

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1733-1742. doi:https://doi.org/10.1167/iovs.14-15450

Effect of Myopia on the Progression of Primary Open-Angle Glaucoma Free

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Jin Young Lee; Kyung Rim Sung; Seungbong Han; Jung Hwa Na

Tags: glaucoma, myopia, open-angle glaucoma, optic disk, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1775-1781. doi:https://doi.org/10.1167/iovs.14-16002

Morphometry of the Trabecular Meshwork In Vivo in a Healthy Population Using Fourier-Domain Optical Coherence Tomography Free

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José I. Fernández-Vigo; Julián García-Feijóo; Jose M. Martínez-de-la-Casa; Javier García-Bella; José A. Fernández-Vigo

Tags: optical coherence tomography, trabecular meshwork, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1782-1788. doi:https://doi.org/10.1167/iovs.14-16154

Differential Protection of Injured Retinal Ganglion Cell Dendrites by Brimonidine Free

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James D. Lindsey; Karen X. Duong-Polk; Dustin Hammond; Panida Chindasub; Christopher Kai-shun Leung; Robert N. Weinreb

Tags: brimonidine, dendrites, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1789-1804. doi:https://doi.org/10.1167/iovs.14-13892

BDNF Rescues RGCs But Not Intrinsically Photosensitive RGCs in Ocular Hypertensive Albino Rat Retinas Free

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Francisco J. Valiente-Soriano; Francisco M. Nadal-Nicolás; Manuel Salinas-Navarro; Manuel Jiménez-López; Jose M. Bernal-Garro; Maria P. Villegas-Pérez; Marta Agudo-Barriuso; Manuel Vidal-Sanz

Tags: brain-derived neurotrophic factor, ocular hypertension, retina, albinism, melanopsin

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1924-1936. doi:https://doi.org/10.1167/iovs.15-16454

Progressive Degeneration of Retinal and Superior Collicular Functions in Mice With Sustained Ocular Hypertension Free

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Hui Chen; Yan Zhao; Mingna Liu; Liang Feng; Zhen Puyang; Ji Yi; Peiji Liang; Hao F. Zhang; Jianhua Cang; John B. Troy; Xiaorong Liu

Tags: glaucoma, mice, ocular hypertension, tissue degeneration, vision

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1971-1984. doi:https://doi.org/10.1167/iovs.14-15691

Collagen Microstructural Factors Influencing Optic Nerve Head Biomechanics Free

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Liang Zhang; Julie Albon; Hannah Jones; Cecile L. M. Gouget; C. Ross Ethier; James C. H. Goh; Michaël J. A. Girard

Tags: biomechanics, collagen, glaucoma, optic disk, sclera

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2031-2042. doi:https://doi.org/10.1167/iovs.14-15734

Corneoscleral Limbus in Glaucoma Patients: In Vivo Confocal Microscopy and Immunocytological Study Free

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Rodolfo Mastropasqua; Luca Agnifili; Vincenzo Fasanella; Claudia Curcio; Lorenza Brescia; Manuela Lanzini; Michela Fresina; Leonardo Mastropasqua; Giorgio Marchini

Tags: glaucoma, limbus corneae, microscopy, confocal, dry eye syndromes, epithelium

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2050-2058. doi:https://doi.org/10.1167/iovs.14-15890

Lamina Cribrosa Depth in Different Stages of Glaucoma Free

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Sung Chul Park; John Brumm; Rafael L. Furlanetto; Camila Netto; Yiyi Liu; Celso Tello; Jeffrey M. Liebmann; Robert Ritch

Tags: glaucoma, cribriform plate, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2059-2064. doi:https://doi.org/10.1167/iovs.14-15540

Development of a New Fully Automated Kinetic Algorithm (Program K) for Detection of Glaucomatous Visual Field Loss Free

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Shigeki Hashimoto; Chota Matsumoto; Sachiko Okuyama; Sonoko Takada; Eiko Arimura-Koike; Yoshikazu Shimomura

Tags: glaucomatous visual field defect, kinetics, perimetry

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2092-2099. doi:https://doi.org/10.1167/iovs.14-16182

Immunology and Microbiology

Aqueous Cell Differentiation in Anterior Uveitis Using Fourier-Domain Optical Coherence Tomography Free

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Jennifer Rose-Nussbaumer; Yan Li; Phoebe Lin; Eric Suhler; Mark Asquith; James T. Rosenbaum; David Huang

Tags: cell differentiation, diagnostic imaging, optical coherence tomography, uveitis, anterior, uveitis

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1430-1436. doi:https://doi.org/10.1167/iovs.14-15118

In Vivo Role of TLR2 and MyD88 Signaling in Eliciting Innate Immune Responses in Staphylococcal Endophthalmitis Free

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Deepa Talreja; Pawan Kumar Singh; Ashok Kumar

Tags: endophthalmitis, mice, myd88 gene, toll-like receptor 2, bacterial endophthalmitis

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1719-1732. doi:https://doi.org/10.1167/iovs.14-16087

Local Production of the Alternative Pathway Component Factor B Is Sufficient to Promote Laser-Induced Choroidal Neovascularization Free

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Gloriane Schnabolk; Beth Coughlin; Kusumam Joseph; Kannan Kunchithapautham; Mausumi Bandyopadhyay; Elizabeth C. O'Quinn; Tamara Nowling; Bärbel Rohrer

Tags: choroidal neovascularization, complement factor b, lasers, mice, complement system proteins

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1850-1863. doi:https://doi.org/10.1167/iovs.14-15910

Lens

Changes in Monkey Crystalline Lens Spherical Aberration During Simulated Accommodation in a Lens Stretcher Free

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Bianca Maceo Heilman; Fabrice Manns; Alberto de Castro; Heather Durkee; Esdras Arrieta; Susana Marcos; Jean-Marie Parel

Tags: gurneys, lens (device), lens, crystalline, visual accommodation, cercopithecidae

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1743-1750. doi:https://doi.org/10.1167/iovs.14-16057

The Zonules Selectively Alter the Shape of the Lens During Accommodation Based on the Location of Their Anchorage Points Free

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Derek Nankivil; Bianca Maceo Heilman; Heather Durkee; Fabrice Manns; Klaus Ehrmann; Shawn Kelly; Esdras Arrieta-Quintero; Jean-Marie Parel

Tags: lens (device), lens, crystalline, visual accommodation, stretching exercises

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1751-1760. doi:https://doi.org/10.1167/iovs.14-16082

Multidisciplinary Ophthalmic Imaging

Peripapillary Choroidal Thickness in Young Asians With High Myopia Free

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Preeti Gupta; Carol Y. Cheung; Seang-Mei Saw; Mayuri Bhargava; Colin S. Tan; Mellisa Tan; Adeline Yang; Frederick Tey; Gerard Nah; Paul Zhao; Tien Yin Wong; Ching-Yu Cheng

Tags: asian, eye, myopia, staphyloma, choroid

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1475-1481. doi:https://doi.org/10.1167/iovs.14-15742

Accuracy Assessment of Intra- and Intervisit Fundus Image Registration for Diabetic Retinopathy Screening Free

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Kedir M. Adal; Peter G. van Etten; Jose P. Martinez; Lucas J. van Vliet; Koenraad A. Vermeer

Tags: diabetic retinopathy, mosaicism, retina, screening

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1805-1812. doi:https://doi.org/10.1167/iovs.14-15949

Large Gene Deletion and Changes in Corneal Endothelial Cells in a Family With Choroideremia Free

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Shih-Yun Lee; Wei-Kuang Yu; Po-Kang Lin

Tags: choroideremia, cornea, corneal endothelium, endothelial cells, family

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1887-1893. doi:https://doi.org/10.1167/iovs.14-16302

Nantotechnology and Regenerative Medicine

Retinal Origin of Electrically Evoked Potentials in Response to Transcorneal Alternating Current Stimulation in the Rat Free

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Andrzej T. Foik; Ewa Kublik; Elena G. Sergeeva; Turgut Tatlisumak; Paolo M. Rossini; Bernhard A. Sabel; Wioletta J. Waleszczyk

Tags: alternating current, evoked potentials, evoked potentials, visual, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1711-1718. doi:https://doi.org/10.1167/iovs.14-15617

Retina

Fully Automatic Segmentation of Fluorescein Leakage in Subjects With Diabetic Macular Edema Free

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Hossein Rabbani; Michael J. Allingham; Priyatham S. Mettu; Scott W. Cousins; Sina Farsiu

Tags: diabetic macular edema, fluorescein, diagnostic imaging, muscle rigidity

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1482-1492. doi:https://doi.org/10.1167/iovs.14-15457

Fundus Autofluorescence Characteristics of Nascent Geographic Atrophy in Age-Related Macular Degeneration Free

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Zhichao Wu; Chi D. Luu; Lauren N. Ayton; Jonathan K. Goh; Lucia M. Lucci; William C. Hubbard; Jill L. Hageman; Gregory S. Hageman; Robyn H. Guymer

Tags: age-related macular degeneration, atrophy, drusen, fundus autofluorescence imaging

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1546-1552. doi:https://doi.org/10.1167/iovs.14-16211

Measurement of Retinal Blood Flow in Normal Chinese-American Subjects by Doppler Fourier-Domain Optical Coherence Tomography Free

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Sowmya Srinivas; Ou Tan; Shuang Wu; Muneeswar Gupta Nittala; David Huang; Rohit Varma; SriniVas R. Sadda

Tags: chinese (other dialects), chinese people, optical coherence tomography, vascular flow, eye

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1569-1574. doi:https://doi.org/10.1167/iovs.14-15038

Ultrasound-Based Quantification of Vitreous Floaters Correlates with Contrast Sensitivity and Quality of Life Free

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Jonathan Mamou; Christianne A. Wa; Kenneth M. P. Yee; Ronald H. Silverman; Jeffrey A. Ketterling; Alfredo A. Sadun; J. Sebag

Tags: contrast sensitivity, ultrasonography, vitreous floaters, eye, quality of life

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1611-1617. doi:https://doi.org/10.1167/iovs.14-15414

Exogenous Superoxide Dismutase Mimetic Without Scavenging H₂O₂ Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy Free

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Shamin Jivabhai Patel; Fayez Bany-Mohammed; Lois McNally; Gloria B. Valencia; Douglas R. Lazzaro; Jacob V. Aranda; Kay D. Beharry

Tags: antioxidants, normal saline, oxidative stress, oxygen, photoreceptors

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1665-1677. doi:https://doi.org/10.1167/iovs.14-15321

In Vivo Quantification of Retinal Changes Associated With Drusen in Age-Related Macular Degeneration Free

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James Rogala; Barbara Zangerl; Nagi Assaad; Erica L. Fletcher; Michael Kalloniatis; Lisa Nivison-Smith

Tags: drusen, age-related macular degeneration

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1689-1700. doi:https://doi.org/10.1167/iovs.14-16221

Identification of miRNAs in a Model of Retinal Degenerations Free

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Kartik Saxena; Matthew Viktor Rutar; Jan M. Provis; Riccardo Carlo Natoli

Tags: micrornas, retinal degeneration

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1820-1829. doi:https://doi.org/10.1167/iovs.14-15449

Retinal Vessel Pathologies in a Rat Model of Periventricular Leukomalacia: A New Model for Retinopathy of Prematurity? Free

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Janina Steck; Carolin Blueml; Susanne Kampmann; Brandon Greene; Rolf F. Maier; Stefan Arnhold; Bettina Gerstner; Knut Stieger; Birgit Lorenz

Tags: eye, gene expression, hyperoxia, hypoxia, ischemia

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1830-1841. doi:https://doi.org/10.1167/iovs.14-15262

Scleral Thinning After Repeated Intravitreal Injections of Antivascular Endothelial Growth Factor Agents in the Same Quadrant Free

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Martin S. Zinkernagel; Petra Schorno; Andreas Ebneter; Sebastian Wolf

Tags: anti-vascular endothelial growth factor therapy, endothelial growth factors, injections, intravitreal injections, sclera

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1894-1900. doi:https://doi.org/10.1167/iovs.14-16204

Choroidal Vascular Hyperpermeability and Punctate Hyperfluorescent Spot in Choroidal Neovascularization Free

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Jae Hui Kim; Young Suk Chang; Tae Gon Lee; Chul Gu Kim

Tags: choroidal neovascularization, exanthema, eye, prevalence

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1909-1915. doi:https://doi.org/10.1167/iovs.14-16000

Disorganized Retinal Lamellar Structures in Nonperfused Areas of Diabetic Retinopathy Free

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Yoko Dodo; Tomoaki Murakami; Akihito Uji; Shin Yoshitake; Nagahisa Yoshimura

Tags: diabetic retinopathy, eye, ischemia, macular disorders, ganglia

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2012-2020. doi:https://doi.org/10.1167/iovs.14-15924

Impact of Reticular Pseudodrusen on Microperimetry and Multifocal Electroretinography in Intermediate Age-Related Macular Degeneration Free

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Zhichao Wu; Lauren N. Ayton; Galina Makeyeva; Robyn H. Guymer; Chi D. Luu

Tags: age-related macular degeneration, electroretinography, eye, vision, drusen

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2100-2106. doi:https://doi.org/10.1167/iovs.14-16210

Retinal Cell Biology

Protective Effects of Glucosamine on Oxidative-Stress and Ischemia/Reperfusion-Induced Retinal Injury Free

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Ying-Jen Chen; Yuahn-Sieh Huang; Jiann-Torng Chen; Yi-Hao Chen; Ming-Cheng Tai; Ching-Long Chen; Chang-Min Liang

Tags: apoptosis, glucosamine, ischemia, oxidative stress, physiologic reperfusion

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1506-1516. doi:https://doi.org/10.1167/iovs.14-15726

Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow–Derived Cells Differ Markedly in Their Production of IL-1β and IL-18 Free

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Guangpu Shi; Siqi Chen; Wambui S. Wandu; Osato Ogbeifun; Lindsey F. Nugent; Arvydas Maminishkis; Samuel J. H. Hinshaw; Ignacio R. Rodriguez; Igal Gery

Tags: bone marrow, inflammasomes, interleukin-18, retinal pigment cell, cytokine

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1658-1664. doi:https://doi.org/10.1167/iovs.14-14557

TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium Free

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Peter Y. Zhao; Geliang Gan; Shaomin Peng; Shao-Bin Wang; Bo Chen; Ron A. Adelman; Lawrence J. Rizzolo

Tags: barium, cell membrane, fetus, proteins, retinal pigment epithelium

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1916-1923. doi:https://doi.org/10.1167/iovs.14-15738

The Chemokine Platelet Factor-4 Variant (PF-4var)/CXCL4L1 Inhibits Diabetes-Induced Blood–Retinal Barrier Breakdown Free

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Ahmed M. Abu El-Asrar; Ghulam Mohammad; Mohd Imtiaz Nawaz; Mohammed Abdelsaid; Mohammad Mairaj Siddiquei; Kaiser Alam; Kathleen Van den Eynde; Gert De Hertogh; Ghislain Opdenakker; Mohamed Al-Shabrawey; Jo Van Damme; Sofie Struyf

Tags: blood-retinal barrier, diabetes mellitus, streptozocin, vascular endothelial growth factor a, rats

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1956-1964. doi:https://doi.org/10.1167/iovs.14-16144

Comparing the Mode of Action of Intraocular Lutein-Based Dyes With Synthetic Dyes Free

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Diogo Sousa-Martins; Luciano Caseli; Mafalda C. Figueiredo; Claudia Sa e Cunha; Helder Mota-Filipe; Acácio Souza-Lima; Rubens Belfort, Jr; Eduardo Rodrigues; Mauricio Maia

Tags: dyes, lutein, tissue membrane

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1993-2000. doi:https://doi.org/10.1167/iovs.14-16187

Visual Neuroscience

Photoreceptor Regulation of Spatial Visual Behavior Free

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Nazia M. Alam; Cara M. Altimus; Robert M. Douglas; Samer Hattar; Glen T. Prusky

Tags: luminance, mice, photoreceptors, regulation, retinal cone

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1842-1849. doi:https://doi.org/10.1167/iovs.14-15644

Visual Psychophysics and Physiological Optics

Eye Movement and Pupil Size Constriction Under Discomfort Glare Free

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Yandan Lin; Steve Fotios; Minchen Wei; Yihong Liu; Weihong Guo; Yaojie Sun

Tags: constriction procedure, eye movement, glare, pupil size

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1649-1656. doi:https://doi.org/10.1167/iovs.14-15963

Increased Visual Sensitivity Following Periods of Dim Illumination Free

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Alex S. McKeown; Timothy W. Kraft; Michael S. Loop

Tags: conditioning (psychology), light, lighting, mice, noise

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1864-1871. doi:https://doi.org/10.1167/iovs.14-15958

Clinical Trials

The Association Between Subjective and Objective Parameters for the Assessment of Dry-Eye Syndrome Free

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Doreen Schmidl; Katarzyna Jadwiga Witkowska; Semira Kaya; Carina Baar; Henrik Faatz; Johannes Nepp; Angelika Unterhuber; René Marcel Werkmeister; Gerhard Garhofer; Leopold Schmetterer

Tags: dry eye syndromes, signs and symptoms, syndrome, tear film finding, osmolar concentration

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1467-1472. doi:https://doi.org/10.1167/iovs.14-15814

Peripapillary Choroidal Thickness Variation With Age and Race in Normal Eyes Free

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Lindsay A. Rhodes; Carrie Huisingh; John Johnstone; Massimo A. Fazio; Brandon Smith; Lan Wang; Mark Clark; J. Crawford Downs; Cynthia Owsley; Michael J. A. Girard; Jean Martial Mari; Christopher A. Girkin

Tags: continental population groups, eye, choroid, optic disk

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1872-1879. doi:https://doi.org/10.1167/iovs.14-16179

Prospective Trial of Intense Pulsed Light for the Treatment of Meibomian Gland Dysfunction Free

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Jennifer P. Craig; Yen-Heng Chen; Philip R. K. Turnbull

Tags: eye, intense pulsed light therapy, lipids, meibomian gland, pathophysiology

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1965-1970. doi:https://doi.org/10.1167/iovs.14-15764

Review

Latest Updates on Antiretinal Autoantibodies Associated With Vision Loss and Breast Cancer Free

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Grazyna Adamus

Tags: autoantibodies, blindness, breast cancer, antigens, proteins

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1680-1688. doi:https://doi.org/10.1167/iovs.14-15739

Letters to the Editor

CNGB3-Achromatopsia Clinical Trial With CNTF: Diminished Rod Pathway Responses With No Evidence of Improvement in Cone Function Free

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Christopher Langlo; Adam Dubis; Michel Michaelides; Joseph Carroll

Tags: achromatopsia, ciliary neurotrophic factor, retinal cone, rod photoreceptors

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1505. doi:https://doi.org/10.1167/iovs.14-15897

More to Stable Tears Than Thickness of the Tear Film Lipid Layer Free

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Beau J. Fenner; Louis Tong

Tags: lipids, tear film finding

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1601. doi:https://doi.org/10.1167/iovs.15-16490

Author Response: More to Stable Tears Than Thickness of the Lipid Layer Free

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P. Ewen King-Smith; Richard J. Braun

Tags: lipids

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1602. doi:https://doi.org/10.1167/iovs.15-16607

Effect of Photocoagulation of Ischemic Areas to Prevent Recurrence of Diabetic Macular Edema Free

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Colin S. Tan; Milton C. Chew; Louis W. Lim; SriniVas R. Sadda

Tags: diabetic macular edema, ischemia, light coagulation, recurrence

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1609. doi:https://doi.org/10.1167/iovs.14-16365

Author Response: Effect of Photocoagulation of Ischemic Areas to Prevent Recurrence of Diabetic Macular Edema Free

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Yoshihiro Takamura

Tags: diabetic macular edema, ischemia, light coagulation, recurrence

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1610. doi:https://doi.org/10.1167/iovs.15-16592

Retinal Capillary Flow and Diabetic Retinopathy Free

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Michael Quigley

Tags: blood capillaries, diabetic retinopathy, fluid flow

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2001. doi:https://doi.org/10.1167/iovs.15-16574

Author Response: Retinal Capillary Flow and Diabetic Retinopathy Free

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Ryan Eyn Kidd Man; Muhammad Bayu Sasongko; Jie Jin Wang; Ecosse L. Lamoureux

Tags: blood capillaries, diabetic retinopathy, fluid flow

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2002. doi:https://doi.org/10.1167/iovs.15-16697

Erratum

Erratum Free

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Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1473-1474. doi:https://doi.org/10.1167/iovs.13-13054a

Erratum Free

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Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1593. doi:https://doi.org/10.1167/iovs.12-9989a

Erratum Free

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Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1679. doi:https://doi.org/10.1167/iovs.14-14706a

Erratum Free

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Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1947. doi:https://doi.org/10.1167/iovs.15-16479a

Erratum Free

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Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2114-2115. doi:https://doi.org/10.1167/iovs.14-16035a

Retraction

Retraction: Sclera-Choroid-RPE Transport of Eight β-Blockers in Human, Bovine, Porcine, Rabbit, and Rat Models Free

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David C. Beebe

Tags: biological transport, cattle, choroid, oryctolagus cuniculus, sclera

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 1678. doi:https://doi.org/10.1167/iovs.10-6233a

Index

Reviewers Free

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Tags: antineutrophil cytoplasmic autoantibody, arthritis, juvenile rheumatoid, burns, calculi, christianity

Investigative Ophthalmology & Visual Science March 2015, Vol.56, 2117-2125. doi:https://doi.org/10.1167/iovs.15-16841

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