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Research Highlight

Next-Generation Sequencing in the Clinical Diagnosis of Retinitis Pigmentosa Free
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Robert Wojciechowski
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2183. doi:https://doi.org/10.1167/iovs.15-16765
Homozygous Nonsense Mutations in RBP3 Gene Cause Early-Onset Retinal Dystrophies Associated With High Myopia Free
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Marc M. Abitbol
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2366. doi:https://doi.org/10.1167/iovs.15-16876

Anatomy and Pathology/Oncology

A Murine Model for Metastatic Conjunctival Melanoma Free
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Nadine E. de Waard; Jinfeng Cao; Sean P. McGuire; Paraskevi E. Kolovou; Ekaterina S. Jordanova; Bruce R. Ksander; Martine J. Jager
Tags: cell lines, malignant melanoma of conjunctiva, neoplasm metastasis, neoplasms, transplantation, heterologous
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2325-2333. doi:https://doi.org/10.1167/iovs.14-15239
Tumor Regression After Brachytherapy for Choroidal Melanoma: Reduction of Thickness and Cross-Sectional Area by Shape and Regression Pattern Free
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Mamunur Rashid; Jorma Heikkonen; Tero Kivelä
Tags: brachytherapy, malignant melanoma of choroid, neoplasms, tumor regression, uveal melanoma
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2612-2623. doi:https://doi.org/10.1167/iovs.14-16322

Biochemistry and Molecular Biology

Changes in Mitochondrial Morphology and Bioenergetics in Human Lymphoblastoid Cells With Four Novel OPA1 Mutations Free
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Shu-Huei Kao; May-Yung Yen; An-Guor Wang; Yi-Ling Yeh; An-Lo Lin
Tags: mitochondria, mutation, optic atrophy, autosomal dominant, bioenergetics
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2269-2278. doi:https://doi.org/10.1167/iovs.14-16288
Antiangiogenic Effectiveness of the Urokinase Receptor-Derived Peptide UPARANT in a Model of Oxygen-Induced Retinopathy Free
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Massimo Dal Monte; Sara Rezzola; Maurizio Cammalleri; Mirella Belleri; Filippo Locri; Lucia Morbidelli; Michela Corsini; Giuseppe Paganini; Francesco Semeraro; Anna Cancarini; Dario Rusciano; Marco Presta; Paola Bagnoli
Tags: angiogenesis, angiogenesis inhibitors, mice, oxygen, peptides
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2392-2407. doi:https://doi.org/10.1167/iovs.14-16323
Daily Injection But Not Continuous Infusion of Apomorphine Inhibits Form-Deprivation Myopia in Mice Free
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Tingting Yan; Weiwei Xiong; Furong Huang; Fan Zheng; Huangfang Ying; Jiang-Fan Chen; Jia Qu; Xiangtian Zhou
Tags: apomorphine, intravenous infusion, continuous, mice, myopia, infusion procedures
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2475-2485. doi:https://doi.org/10.1167/iovs.13-12361
Ornithine-δ-Aminotransferase Inhibits Neurogenesis During Xenopus Embryonic Development Free
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Ying Peng; Sandra K. Cooper; Yi Li; Jay M. Mei; Shuwei Qiu; Gregory L. Borchert; Steven P. Donald; Hsiang-fu Kung; James M. Phang
Tags: embryo, embryologic development, neural development, ornithine, transaminases
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2486-2497. doi:https://doi.org/10.1167/iovs.15-16509
A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation Free
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Yuanyuan Chen; Hong Tang; William Seibel; Ruben Papoian; Xiaoyu Li; Nevin A. Lambert; Krzysztof Palczewski
Tags: opsin
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2553-2567. doi:https://doi.org/10.1167/iovs.14-16298
Quercetin and Resveratrol Decrease the Inflammatory and Oxidative Responses in Human Ocular Surface Epithelial Cells Free
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Antonio Abengózar-Vela; Margarita Calonge; Michael E. Stern; María Jesús González-García; Amalia Enríquez-De-Salamanca
Tags: bodily secretions, cell lines, cytokine, epithelial cells, polyphenols
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2709-2719. doi:https://doi.org/10.1167/iovs.15-16595

Clinical and Epidemiologic Research

Association Between Systemic Hypertension and Macular Thickness Measured by Optical Coherence Tomography Free
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Mingui Kong; Youngkyo Kwun; Joohon Sung; Don-Il Ham; Yun-Mi Song
Tags: hypertension, optical coherence tomography, cardiometabolic risk factors
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2144-2150. doi:https://doi.org/10.1167/iovs.14-16080
Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates Free
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Johanna M. Seddon; Rachel E. Silver; Manlik Kwong; Bernard Rosner
Tags: demography, genetics, macular degeneration, genes, age-related macular degeneration
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2192-2202. doi:https://doi.org/10.1167/iovs.14-15841
Functional Visual Improvement After Cataract Surgery in Eyes With Age-Related Macular Degeneration: Results of the Ophthalmic Surgical Outcomes Data Project Free
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Michael V. Stock; David E. Vollman; Elizabeth F. Baze; Amy S. Chomsky; Mary K. Daly; Mary G. Lawrence
Tags: age-related macular degeneration, cataract surgery, eye, surgical outcome, vision
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2536-2540. doi:https://doi.org/10.1167/iovs.14-16069
Risk Factors for Age-Related Macular Degeneration in an Elderly Japanese Population: The Hatoyama Study Free
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Aya Aoki; Xue Tan; Reiko Yamagishi; Shoji Shinkai; Ryo Obata; Tempei Miyaji; Takuhiro Yamaguchi; Jiro Numaga; Hideki Ito; Yasuo Yanagi
Tags: age-related macular degeneration, japanese, older adult, risk factors, cohort studies
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2580-2585. doi:https://doi.org/10.1167/iovs.14-16339
Changes in Choroidal Thickness After Panretinal Photocoagulation for Diabetic Retinopathy: A 12-Week Longitudinal Study Free
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Zhengwei Zhang; Xiaomei Meng; Zhifeng Wu; Wenjun Zou; Jie Zhang; Dongyuan Zhu; Tiantian Chen; Qing Zhang
Tags: diabetic retinopathy, eye, longitudinal studies, panretinal photocoagulation
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2631-2638. doi:https://doi.org/10.1167/iovs.14-16226

Cornea

Pigment Epithelial-Derived Factor Peptide Facilitates the Regeneration of a Functional Limbus in Rabbit Partial Limbal Deficiency Free
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Shu-I Yeh; Tsung-Chuan Ho; Show-Li Chen; Chie-Pein Chen; Huey-Chuan Cheng; Yu-Wen Lan; Jui-Wen Hsieh; Chin-Tien Wang; Yeou-Ping Tsao
Tags: cornea, epithelium, oryctolagus cuniculus, peptides, pigment
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2126-2134. doi:https://doi.org/10.1167/iovs.14-15983
Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction Free
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In-Cheon You; Fang Bian; Eugene A. Volpe; Cintia S. de Paiva; Stephen C. Pflugfelder
Tags: conjunctival diseases, hay-wells syndrome, mice, sjogren's syndrome, mice, inbred c57bl
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2224-2233. doi:https://doi.org/10.1167/iovs.14-15668
Impact of Blur on Suprathreshold Scaling of Ocular Discomfort Free
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Subam Basuthkar Sundar Rao; Trefford L. Simpson
Tags: cornea, lens (device), pain, sensory perception, transducers
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2304-2311. doi:https://doi.org/10.1167/iovs.14-14931
Automated Grading System for Evaluation of Superficial Punctate Keratitis Associated With Dry Eye Free
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John D. Rodriguez; Keith J. Lane; George W. Ousler, III; Endri Angjeli; Lisa M. Smith; Mark B. Abelson
Tags: cornea, dry eye syndromes, fluorescein stain method, grading system, punctate keratitis
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2340-2347. doi:https://doi.org/10.1167/iovs.14-15318
The Inferior Whorl For Detecting Diabetic Peripheral Neuropathy Using Corneal Confocal Microscopy Free
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Ioannis N. Petropoulos; Maryam Ferdousi; Andrew Marshall; Uazman Alam; Georgios Ponirakis; Shazli Azmi; Hassan Fadavi; Nathan Efron; Mitra Tavakoli; Rayaz A. Malik
Tags: cornea, diabetic neuropathies, microscopy, confocal, neuropathy
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2498-2504. doi:https://doi.org/10.1167/iovs.14-15919
Epithelial–Mesenchymal Transition (EMT)-Related Cytokines in the Aqueous Humor of Phakic and Pseudophakic Fuchs' Dystrophy Eyes Free
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Mario Matthaei; Johannes Gillessen; Philipp S. Muether; Robert Hoerster; Björn O. Bachmann; Arno Hueber; Claus Cursiefen; Ludwig M. Heindl
Tags: aqueous humor, cytokine, epithelial to mesenchymal transition, eye, epithelium
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2749-2754. doi:https://doi.org/10.1167/iovs.15-16395
A Comparative Study of Vertebrate Corneal Structure: The Evolution of a Refractive Lens Free
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Moritz Winkler; Golroxan Shoa; Stephanie T. Tran; Yilu Xie; Sarah Thomasy; Vijay K. Raghunathan; Christopher Murphy; Donald J. Brown; James V. Jester
Tags: collagen, cornea, lens (device), lens, crystalline, vertebrates
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2764-2772. doi:https://doi.org/10.1167/iovs.15-16584

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Location and Gaze-Dependent Shift of Inferior Oblique Muscle Position: Anatomic Contributors to Vertical Strabismus Following Lower Lid Blepharoplasty? Free
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Sun Young Shin; Joseph L. Demer
Tags: blepharoplasty, gaze, hypertropia, inferior oblique muscle, strabismus
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2408-2415. doi:https://doi.org/10.1167/iovs.14-15324
Functional Loss of the Inner Retina in Childhood Optic Gliomas Detected by Photopic Negative Response Free
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Edoardo Abed; Marco Piccardi; Daniela Rizzo; Antonio Chiaretti; Lucia Ambrosio; Sergio Petroni; Rosa Parrilla; Anna Dickmann; Riccardo Riccardi; Benedetto Falsini
Tags: child, electroretinography, erg protein, human, optic nerve glioma, retina
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2469-2474. doi:https://doi.org/10.1167/iovs.14-16235
Uncorrected Myopic Refractive Error Increases Microsaccade Amplitude Free
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Fatema F. Ghasia; Aasef G. Shaikh
Tags: refractive errors
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2531-2535. doi:https://doi.org/10.1167/iovs.14-15882
Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia Free
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Yi Pang; Kelly A. Frantz; Sandra Block; Geoffrey W. Goodfellow; Christine Allison
Tags: amblyopia, anisometropic amblyopia, eye
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2677-2683. doi:https://doi.org/10.1167/iovs.14-15532

Genetics

Targeted Next-Generation Sequencing Improves the Diagnosis of Autosomal Dominant Retinitis Pigmentosa in Spanish Patients Free
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Patricia Fernandez-San Jose; Marta Corton; Fiona Blanco-Kelly; Almudena Avila-Fernandez; Miguel Angel Lopez-Martinez; Iker Sanchez-Navarro; Rocio Sanchez-Alcudia; Raquel Perez-Carro; Olga Zurita; Noelia Sanchez-Bolivar; Maria Isabel Lopez-Molina; Blanca Garcia-Sandoval; Rosa Riveiro-Alvarez; Carmen Ayuso
Tags: family, massively-parallel genome sequencing, mutation, retinitis pigmentosa, spanish
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2173-2182. doi:https://doi.org/10.1167/iovs.14-16178
The Relationship Between Aldose Reductase C106T Polymorphism and Diabetic Retinopathy: An Updated Meta-Analysis Free
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Minwen Zhou; Pengfei Zhang; Xun Xu; Xiaodong Sun
Tags: aldehyde reductase, diabetic retinopathy, meta-analysis, polymorphism, disease susceptibility
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2279-2289. doi:https://doi.org/10.1167/iovs.14-16279
Lack of Interphotoreceptor Retinoid Binding Protein Caused by Homozygous Mutation of RBP3 Is Associated With High Myopia and Retinal Dystrophy Free
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Gavin Arno; Sarah Hull; Anthony G. Robson; Graham E. Holder; Michael E. Cheetham; Andrew R. Webster; Vincent Plagnol; Anthony T. Moore
Tags: e2f1 gene, family, homozygote, mutation, mutation, nonsense
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2358-2365. doi:https://doi.org/10.1167/iovs.15-16520
Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population Free
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Yuhong Chen; Guy Hughes; Xueli Chen; Shaohong Qian; Wenjun Cao; Li Wang; Min Wang; Xinghuai Sun
Tags: chinese (other dialects), chinese people, genetics, glaucoma, intraocular pressure
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2595-2600. doi:https://doi.org/10.1167/iovs.14-16269
Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension Free
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Shinwu Jeong; Nitin Patel; Christopher K. Edlund; Jaana Hartiala; Dennis J. Hazelett; Tatsuo Itakura; Pei-Chang Wu; Robert L. Avery; Janet L. Davis; Harry W. Flynn; Geeta Lalwani; Carmen A. Puliafito; Hussein Wafapoor; Minako Hijikata; Naoto Keicho; Xiaoyi Gao; Pablo Argüeso; Hooman Allayee; Gerhard A. Coetzee; Mathew T. Pletcher; David V. Conti; Stephen G. Schwartz; Alexander M. Eaton; M. Elizabeth Fini
Tags: cohort studies, genes, intraocular pressure, mucins, ocular hypertension
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2737-2748. doi:https://doi.org/10.1167/iovs.14-14803

Glaucoma

Evaluation of Choroidal Thickness, Intraocular Pressure, and Serum Osmolality After the Water Drinking Test in Eyes With Primary Angle Closure Free
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Monisha E. Nongpiur; Valencia H. X. Foo; John Mark de Leon; Mani Baskaran; Tin A. Tun; Rahat Husain; Shamira A. Perera; Tin Aung
Tags: eye, intraocular pressure, serum osmolality measurement, water drinking
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2135-2143. doi:https://doi.org/10.1167/iovs.14-15280
A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region Free
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Teresa Borrás; Matthew H. Smith; LaKisha K. Buie
Tags: body tissue, genes, glaucoma, mice, sclera
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2203-2214. doi:https://doi.org/10.1167/iovs.15-16460
Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography Free
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Ali S. Raza; Donald C. Hood
Tags: glaucoma, national library of medicine (u.s.), optical coherence tomography, retinal ganglion cells, visual fields
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2254-2268. doi:https://doi.org/10.1167/iovs.14-15952
Applying “Lasso” Regression to Predict Future Visual Field Progression in Glaucoma Patients Free
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Yuri Fujino; Hiroshi Murata; Chihiro Mayama; Ryo Asaoka
Tags: glaucoma, maximum tolerated dose, visual fields, regression analysis
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2334-2339. doi:https://doi.org/10.1167/iovs.15-16445
Viral Vector Effects on Exoenzyme C3 Transferase–Mediated Actin Disruption and on Outflow Facility Free
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Sarah R. Slauson; Donna M. Peters; Marie K. Schwinn; Paul L. Kaufman; B'Ann T. Gabelt; Curtis R. Brandt
Tags: actins, adenoviruses, exoenzymes, transferase, viral vector
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2431-2438. doi:https://doi.org/10.1167/iovs.14-15909
Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: A Prospective Study Free
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Jae H. Kang; Stephanie J. Loomis; Bernard A. Rosner; Janey L. Wiggs; Louis R. Pasquale
Tags: open-angle glaucoma, risk factors, blindness, prospective studies
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2439-2448. doi:https://doi.org/10.1167/iovs.14-16088
IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys Free
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Shinsaku Yamane; Tomohiro Karakawa; Satoshi Nakayama; Kazufumi Nagai; Kazumi Moriyuki; Shinichi Neki; Fumitaka Suto; Tohru Kambe; Yasushi Hirota; Kazuhito Kawabata
Tags: agonists, cercopithecidae, intraocular pressure, prostaglandins
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2547-2552. doi:https://doi.org/10.1167/iovs.14-16181
Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model Free
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Shota Kojima; Tetsuya Sugiyama; Shinji Takai; Denan Jin; Mari Ueki; Hidehiro Oku; Yasuhiko Tabata; Tsunehiko Ikeda
Tags: blister, cicatrix, conjunctiva, dog, domestic, eye
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2601-2605. doi:https://doi.org/10.1167/iovs.15-16486
Analysis of Circadian Rhythm Gene Expression With Reference to Diurnal Pattern of Intraocular Pressure in Mice Free
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Lauren A. Dalvin; Michael P. Fautsch
Tags: circadian rhythms, gene expression, intraocular pressure, mice
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2657-2663. doi:https://doi.org/10.1167/iovs.15-16449

Immunology and Microbiology

Recruitment of Donor T Cells to the Eyes During Ocular GVHD in Recipients of MHC-Matched Allogeneic Hematopoietic Stem Cell Transplants Free
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Samantha Herretes; Duncan B. Ross; Stephanie Duffort; Henry Barreras; Tan Yaohong; Ali M. Saeed; Juan C. Murillo; Krishna V. Komanduri; Robert B. Levy; Victor L. Perez
Tags: donors, eye, graft-versus-host disease, t-lymphocytes, allogeneic hematopoietic stem cell transplant
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2348-2357. doi:https://doi.org/10.1167/iovs.14-15630
Proteomics Differentiate Between Thyroid-Associated Orbitopathy and Dry Eye Syndrome Free
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Nina Matheis; Franz H. Grus; Matthias Breitenfeld; Ivo Knych; Sebastian Funke; Susanne Pitz; Katharina A. Ponto; Norbert Pfeiffer; George J. Kahaly
Tags: dry eye syndromes, proteins, proteomics, thyroid, antibodies
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2649-2656. doi:https://doi.org/10.1167/iovs.15-16699
Inhibition of Corneal Inflammation by the Resolvin E1 Free
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Ji-Eun Lee; Yan Sun; Per Gjorstrup; Eric Pearlman
Tags: bacteria, cornea, cytokine, keratitis, neutrophils
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2728-2736. doi:https://doi.org/10.1167/iovs.14-15982

Low Vision

Difficulties With Goals of the Dutch ICF Activity Inventory: Perceptions of Those With Retinitis Pigmentosa and of Those Who Support Them Free
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Keziah Latham; Mohammad Baranian; Matthew A. Timmis; Shahina Pardhan
Tags: dutch, international classification of functioning, disability and health, perception, retinitis pigmentosa, visual impairment
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2381-2391. doi:https://doi.org/10.1167/iovs.14-16237
The Influence of Coping on Vision-Related Quality of Life in Patients With Low Vision: A Prospective Longitudinal Study Free
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Bonnie A. Sturrock; Jing Xie; Edith E. Holloway; Ecosse L. Lamoureux; Jill E. Keeffe; Eva K. Fenwick; Gwyneth Rees
Tags: coping behavior, prospective studies, quality of life, vision, visual impairment
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2416-2422. doi:https://doi.org/10.1167/iovs.14-16223
Evaluation of a Portable Collision Warning Device for Patients With Peripheral Vision Loss in an Obstacle Course Free
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Shrinivas Pundlik; Matteo Tomasi; Gang Luo
Tags: gait, mobility, peripheral vision, walking speed, walking (activity)
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2571-2579. doi:https://doi.org/10.1167/iovs.14-15935
Repeatability of Nidek MP-1 Fixation Measurements in Patients With Bilateral Central Field Loss Free
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Harold E. Bedell; Joshua D. Pratt; Arunkumar Krishnan; Eli Kisilevsky; Taylor A. Brin; Esther G. González; Martin J. Steinbach; Luminita Tarita-Nistor
Tags: meridians, ocular fixation, eye
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2624-2630. doi:https://doi.org/10.1167/iovs.15-16511

Multidisciplinary Ophthalmic Imaging

Relationship Between Optic Nerve Protrusion Measured by OCT and MRI and Papilledema Severity Free
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Yu-Cherng C. Chang; Noam Alperin; Ahmet M. Bagci; Sang H. Lee; Potyra R. Rosa; Gregori Giovanni; Byron L. Lam
Tags: eye, magnetic resonance imaging, optic nerve, papilledema, optics
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2297-2302. doi:https://doi.org/10.1167/iovs.15-16602
Cardiac-Gated En Face Doppler Measurement of Retinal Blood Flow Using Swept-Source Optical Coherence Tomography at 100,000 Axial Scans per Second Free
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ByungKun Lee; WooJhon Choi; Jonathan J. Liu; Chen D. Lu; Joel S. Schuman; Gadi Wollstein; Jay S. Duker; Nadia K. Waheed; James G. Fujimoto
Tags: face, ion channel gating, optical coherence tomography, vascular flow, diagnostic imaging
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2522-2530. doi:https://doi.org/10.1167/iovs.14-16119

Nantotechnology and Regenerative Medicine

A Novel Method Using Quantum Dots for Testing the Barrier Function of Cultured Epithelial Cell Sheets Free
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Thomas J. Duncan; Koichi Baba; Yoshinori Oie; Kohji Nishida
Tags: epithelial cells, quantum dots
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2215-2223. doi:https://doi.org/10.1167/iovs.14-15579

Physiology and Pharmacology

Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model Free
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Magdalena Bajgrowicz; Chau-Minh Phan; Lakshman N. Subbaraman; Lyndon Jones
Tags: ciprofloxacin, contact lenses, eye, fluoroquinolones, lens (device)
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2234-2242. doi:https://doi.org/10.1167/iovs.15-16379
Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses Free
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Rashmi Katiyar; Petra Weissgerber; Elisabeth Roth; Janka Dörr; Vithiyanjali Sothilingam; Marina Garcia Garrido; Susanne C. Beck; Mathias W. Seeliger; Andreas Beck; Frank Schmitz; Veit Flockerzi
Tags: mice, photoreceptors, retina, synapses, voltage
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2312-2324. doi:https://doi.org/10.1167/iovs.15-16654
Sildenafil Acutely Decreases Visual Responses in ON and OFF Retinal Ganglion Cells Free
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João Martins; Bogdan Kolomiets; Romain Caplette; José-Alain Sahel; Miguel Castelo-Branco; António F. Ambrósio; Serge Picaud
Tags: sildenafil, mass or substance concentration per volume, retinal ganglion cells
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2639-2648. doi:https://doi.org/10.1167/iovs.14-15964
Scleral Thickness in Chinese Eyes Free
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Ling Shen; Qi Sheng You; Xiaolin Xu; Fei Gao; Zhibao Zhang; Bin Li; Jost B. Jonas
Tags: chinese (other dialects), chinese people, eye, sclera
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2720-2727. doi:https://doi.org/10.1167/iovs.14-15631

Retina

Association of Retinal Artery and Other Inner Retinal Structures With Distribution of Tapetal-like Reflex in Oguchi's Disease Free
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Yu Kato; Kazushige Tsunoda; Kaoru Fujinami; Takeshi Iwata; Masamichi Saga; Yoshihisa Oguchi
Tags: central retinal artery, oguchi disease, reflex
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2162-2172. doi:https://doi.org/10.1167/iovs.14-16198
Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation Free
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Katie M. Litts; Jeffrey D. Messinger; K. Bailey Freund; Yuhua Zhang; Christine A. Curcio
Tags: age-related macular degeneration, mitochondria, retinal cone, tissue degeneration, translocation (genetics)
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2243-2253. doi:https://doi.org/10.1167/iovs.14-15838
High-Fat Diet–Induced Retinal Dysfunction Free
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Richard Cheng-An Chang; Liheng Shi; Cathy Chia-Yu Huang; Andy Jeesu Kim; Michael L. Ko; Beiyan Zhou; Gladys Y.-P. Ko
Tags: diabetes mellitus, diet, electroretinography, glucose, insulin
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2367-2380. doi:https://doi.org/10.1167/iovs.14-16143
In Vivo Imaging of Subretinal Bleb-Induced Outer Retinal Degeneration in the Rabbit Free
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Hammurabi Bartuma; Sandra Petrus-Reurer; Monica Aronsson; Sofie Westman; Helder André; Anders Kvanta
Tags: blister, diagnostic imaging, oryctolagus cuniculus, retina, retinal degeneration
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2423-2430. doi:https://doi.org/10.1167/iovs.14-16208
Macular Pigment and Visual Performance in Low-Light Conditions Free
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James M. Stringham; Paul V. Garcia; Peter A. Smith; Paul L. Hiers; Leon N. McLin; Thomas K. Kuyk; Brian K. Foutch
Tags: color, dark adaptation, kinetics, luminance, pigment
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2459-2468. doi:https://doi.org/10.1167/iovs.14-15716
Investigation of the Regulation of Roundabout4 by Hypoxia-Inducible Factor-1α in Microvascular Endothelial Cells Free
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Rui Tian; Zaoxia Liu; Hui Zhang; Xuexun Fang; Chenguang Wang; Shounan Qi; Yan Cheng; Guanfang Su
Tags: endothelial cells, hypoxia, rna, small interfering, proteins, regulation
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2586-2594. doi:https://doi.org/10.1167/iovs.14-14409
Test–Retest Repeatability of Microperimetry at the Border of Deep Scotomas Free
PDF
Zhichao Wu; Chang J. Jung; Lauren N. Ayton; Chi D. Luu; Robyn H. Guymer
Tags: scotoma, optic disk
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2606-2611. doi:https://doi.org/10.1167/iovs.14-15977
Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes Free
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Martin Gliem; Philipp L. Müller; Elisabeth Mangold; Frank G. Holz; Hanno J. Bolz; Heidi Stöhr; Bernhard H. F. Weber; Peter Charbel Issa
Tags: atrophy, choroidal neovascularization, family, mutation, phenotype
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2664-2676. doi:https://doi.org/10.1167/iovs.14-15733
Time-Dependent Changes of Cell Proliferation After Laser Photocoagulation in Mouse Chorioretinal Tissue Free
PDF
Si Hyung Lee; Hoon Dong Kim; Yeo Jin Park; Young-Hoon Ohn; Tae Kwann Park
Tags: bromodeoxyuridine, cell proliferation, lasers, light coagulation, mice
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2696-2708. doi:https://doi.org/10.1167/iovs.14-16112
A Novel Approach of Daunorubicin Application on Formation of Proliferative Retinopathy Using a Porous Silicon Controlled Delivery System: Pharmacodynamics Free
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Huiyuan Hou; Kristyn Huffman; Sandy Rios; William R. Freeman; Michael J. Sailor; Lingyun Cheng
Tags: daunorubicin, diabetic retinopathy, oryctolagus cuniculus, pharmacodynamics, pneumonia severity index
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2755-2763. doi:https://doi.org/10.1167/iovs.15-16526
The Effects of Sonic Hedgehog on Retinal Müller Cells Under High-Glucose Stress Free
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Xiujuan Zhao; Yonghao Li; Shaofen Lin; Yu Cai; Jinglin Zhang; Xiling Yu; Hui Yang; Lu Yang; Xiaohong Chen; Yan Luo; Lin Lu
Tags: diabetes mellitus, glucose, rats, retina, shh gene
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2773-2782. doi:https://doi.org/10.1167/iovs.14-16104

Retinal Cell Biology

Differential Expression of IL-6/gp130 Cytokines, Jak-STAT Signaling and Neuroprotection After Müller Cell Ablation in a Transgenic Mouse Model Free
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Nathan J. Coorey; Weiyong Shen; Ling Zhu; Mark C. Gillies
Tags: ablation, cytokine, interleukin-6, neuroprotection, signal transduction
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2151-2161. doi:https://doi.org/10.1167/iovs.14-15695
Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation Free
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Eri Takahashi; Akira Haga; Hidenobu Tanihara
Tags: genes, neurofibromatosis 2, neurofibromin 2, tumor necrosis factors, epithelial to mesenchymal transition
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2449-2458. doi:https://doi.org/10.1167/iovs.14-16300
TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation Free
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Hiromi Murase; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hideaki Hara
Tags: mertk gene, phagocytosis, retinal pigment epithelium, fluorescence, phagocyte bactericidal dysfunction
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2511-2518. doi:https://doi.org/10.1167/iovs.14-15962
Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia Free
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Shanu Markand; Alan Saul; Penny Roon; Puttur Prasad; Pamela Martin; Rima Rozen; Vadivel Ganapathy; Sylvia B. Smith
Tags: methylenetetrahydrofolate reductase (nadph2), mice, retina, vascular diseases, hyperhomocysteinemia
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2684-2695. doi:https://doi.org/10.1167/iovs.14-16190

Visual Neuroscience

Event-Related Potentials Allow for Optotype-Based Objective Acuity Estimation Free
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Sven P. Heinrich; Isabel Lüth; Michael Bach
Tags: event-related potentials, psychophysics, evoked potentials, visual
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2184-2191. doi:https://doi.org/10.1167/iovs.14-16228
Efficacy of Intravitreal Injections of Antivascular Endothelial Growth Factor Agents in a Rat Model of Anterior Ischemic Optic Neuropathy Free
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Tzu-Lun Huang; Chung-Hsing Chang; Shu-Wen Chang; Kung-Hung Lin; Rong-Kung Tsai
Tags: anterior ischemic optic neuropathy, anti-vascular endothelial growth factor therapy, endothelial growth factors, intravitreal injections, optic neuropathy, ischemic
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2290-2296. doi:https://doi.org/10.1167/iovs.14-15999
An Eye on Brain Integrity: Acute Optic Neuritis Affects Resting State Functional Connectivity Free
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Gregory F. Wu; Matthew R, Brier; Cassie A.-L. Parks; Beau M. Ances; Gregory P. Van Stavern
Tags: brain, eye, optic neuritis, personal integrity, vision
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2541-2546. doi:https://doi.org/10.1167/iovs.14-16315

Letters to the Editor

Outer Retinal Bands Free
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Richard F. Spaide
Tags: exanthema, photoreceptors, retinal cone, rod photoreceptors, pixel
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2505-2506. doi:https://doi.org/10.1167/iovs.15-16456
Author Response: Outer Retinal Bands Free
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Ravi S. Jonnal; Omer P. Kocaoglu; Robert J. Zawadzki; Sang-Hyuck Lee; John S. Werner; Donald T. Miller
Tags: retinal cone, retina, mismatch, tissue membrane
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2507-2510. doi:https://doi.org/10.1167/iovs.15-16756
Reliability of Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells Free
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Wuying Zhou; Yitian Lou; Bingxin Pan; Jinhai Huang
Tags: melanopsin, pupillometry, reliability, retinal ganglion cells
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2519. doi:https://doi.org/10.1167/iovs.15-16672
Author Response: Test–Retest Reliability of Hemifield, Central-Field, and Full-Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells Free
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Shaobo Lei; Herbert C. Goltz; Manokaraananthan Chandrakumar; Agnes M. F. Wong
Tags: melanopsin, pupillometry, reliability, retinal ganglion cells
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2520-2521. doi:https://doi.org/10.1167/iovs.15-16847
Neurological Hemifield Test in Binasal Defects Free
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Gema Rebolleda; Laura Díez-Álvarez; Elena Arrondo; Luis Ley; Juan Martínez-San Millán; Francisco J. Muñoz-Negrete
Tags: blindness, cupping therapy, eye, hemianopsia, internal carotid artery
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2568-2569. doi:https://doi.org/10.1167/iovs.15-16656
Author Response: Neurological Hemifield Test in Binasal Defects Free
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Allison N. McCoy; Harry A. Quigley; Neil R. Miller; Prem S. Subramanian; Pradeep Y. Ramulu; Michael V. Boland
Tags: blindness, glaucoma, nervous system disorders, neuroimaging, nose
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2570. doi:https://doi.org/10.1167/iovs.15-16824

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science April 2015, Vol.56, 2303. doi:https://doi.org/10.1167/iovs.14-15903a
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