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Editorial

A New Transition Free
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Thomas Yorio
Tags: amyotrophic lateral sclerosis, awards and prizes, chin, community, death
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3060. doi:https://doi.org/10.1167/iovs.15-17156

Research Highlight

Implications of Sustained Elevation in Extracellular ATP in Retina Following Chronic Ocular Hypertension Free
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W. Daniel Stamer
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3084. doi:https://doi.org/10.1167/iovs.15-17032

Anatomy and Pathology/Oncology

En Face Imaging of Posterior Precortical Vitreous Pockets Using Swept-Source Optical Coherence Tomography Free
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Hirotaka Itakura; Shoji Kishi; Danjie Li; Hideo Akiyama
Tags: diagnostic imaging, face, optical coherence tomography, vitreous body
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2898-2900. doi:https://doi.org/10.1167/iovs.15-16451
Differential Radiosensitivity of Uveal Melanoma Cell Lines After X-rays or Carbon Ions Radiation Free
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Armelle Calipel; Anne-laure Lux; Sylvain Guérin; Jean-Louis Lefaix; Carine Laurent; Myriam Bernaudin; Frédéric Mouriaux
Tags: carbon, cell lines, diagnostic radiologic examination, ions, radiation
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3085-3094. doi:https://doi.org/10.1167/iovs.14-15930
Eye Growth in Term- And Preterm-Born Eyes Modeled From Magnetic Resonance Images Free
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Robert J. Munro; Anne B. Fulton; Toco Y. P. Chui; Anne Moskowitz; Ramkumar Ramamirtham; Ronald M. Hansen; Sanjay P. Prabhu; James D. Akula
Tags: eye, magnetic resonance imaging, lens (device), lens, crystalline, depression, post-stroke
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3121-3131. doi:https://doi.org/10.1167/iovs.14-15980

Biochemistry and Molecular Biology

Patient-Specific Induced Pluripotent Stem Cell–Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Free
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Padmini P. Polinati; Tanja Ilmarinen; Ras Trokovic; Tuulia Hyotylainen; Timo Otonkoski; Anu Suomalainen; Heli Skottman; Tiina Tyni
Tags: mitochondrial trifunctional protein deficiency, pathogenesis, pluripotent stem cells, retinal diseases, retinal pigment cell
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3371-3382. doi:https://doi.org/10.1167/iovs.14-14007

Clinical and Epidemiologic Research

The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs Free
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Priyanka Chhadva; Abigail Alexander; Allison L. McClellan; Katherine T. McManus; Benjamin Seiden; Anat Galor
Tags: conjunctivochalasis, dry eye syndromes, signs and symptoms
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2867-2871. doi:https://doi.org/10.1167/iovs.14-16337
The Changing Profile of Astigmatism in Childhood: The NICER Study Free
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Lisa O'Donoghue; Karen M. Breslin; Kathryn J. Saunders
Tags: astigmatism, child, cohort studies
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2917-2925. doi:https://doi.org/10.1167/iovs.14-16151
Longitudinal Changes in Choroidal Thickness and Eye Growth in Childhood Free
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Scott A. Read; David Alonso-Caneiro; Stephen J. Vincent; Michael J. Collins
Tags: child, eye, choroid
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3103-3112. doi:https://doi.org/10.1167/iovs.15-16446
Ethnic Variations in Myopia and Ocular Biometry Among Adults in a Rural Community in China: The Yunnan Minority Eye Studies Free
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Chen-Wei Pan; Qin Chen; Xun Sheng; Jun Li; Zhiqiang Niu; Hua Zhou; Tao Wei; Yuansheng Yuan; Hua Zhong
Tags: adult, biometry, china, community, myopia
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3235-3241. doi:https://doi.org/10.1167/iovs.14-16357

Cornea

Regional Assessment of Energy-Producing Metabolic Activity in the Endothelium of Donor Corneas Free
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Mark A. Greiner; Kimberlee A. Burckart; Michael D. Wagoner; Gregory A. Schmidt; Cynthia R. Reed; Chase A. Liaboe; Miles J. Flamme-Wiese; M. Bridget Zimmerman; Robert F. Mullins; Randy H. Kardon; Kenneth M. Goins; Benjamin T. Aldrich
Tags: cornea, corneal endothelium, donors, endothelium, mitochondria
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2803-2810. doi:https://doi.org/10.1167/iovs.15-16442
Dynamic Change of Optical Quality in Patients With Dry Eye Disease Free
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Chia-Hsuan Tan; Antoine Labbé; Qingfeng Liang; Liya Qiao; Christophe Baudouin; Xiuhua Wan; Ningli Wang
Tags: dry eye syndromes, optics, vision, blinking, tear film finding
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2848-2854. doi:https://doi.org/10.1167/iovs.14-15757
Laminin-511 and -521 Enable Efficient In Vitro Expansion of Human Corneal Endothelial Cells Free
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Naoki Okumura; Kazuya Kakutani; Ryohei Numata; Makiko Nakahara; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Shigeru Kinoshita; Noriko Koizumi
Tags: cornea, laminin, endothelial cells, integrins
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2933-2942. doi:https://doi.org/10.1167/iovs.14-15163
Loss of Corneal Epithelial Heparan Sulfate Leads to Corneal Degeneration and Impaired Wound Healing Free
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Vivien Jane Coulson-Thomas; Shao-Hsuan Chang; Lung-Kun Yeh; Yvette May Coulson-Thomas; Yu Yamaguchi; Jeffrey Esko; Chia-Yang Liu; Winston Kao
Tags: cornea, corneal epithelium, epithelium, heparitin sulfate, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3004-3014. doi:https://doi.org/10.1167/iovs.14-15341
Quantum Dot Labeling and Tracking of Cultured Limbal Epithelial Cell Transplants In Vitro Free
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Nuria Genicio; Juan Gallo Paramo; Alex J. Shortt
Tags: cornea, diagnostic imaging, epithelial cells, organ culture techniques, quantum dots
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3051-3059. doi:https://doi.org/10.1167/iovs.14-15973
Phakic Iris-Fixated Intraocular Lens Placement in the Anterior Chamber: Effects on Aqueous Flow Free
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Rodolfo Repetto; Jan O. Pralits; Jennifer H. Siggers; Paolo Soleri
Tags: anterior chamber of eye, fluid flow, immune reconstitution inflammatory syndrome, iris fixation, iris
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3061-3068. doi:https://doi.org/10.1167/iovs.14-16118
Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye Free
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Mi Sun Sung; Zhengri Li; Lian Cui; Ji Suk Choi; Won Choi; Min Jung Park; Soo Hyun Park; Kyung Chul Yoon
Tags: aica ribonucleotide, conjunctiva, cyclosporine, dry eye syndromes, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3149-3158. doi:https://doi.org/10.1167/iovs.14-16153
Repeatability of Corneal Phase Retardation Measurements by Polarization-Sensitive Optical Coherence Tomography Free
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Shinichi Fukuda; Genichiro Kishino; Sujin Hoshi; Simone Beheregaray; Yuta Ueno; Masahiro Fukuda; Deepa Kasaragod; Yoshiaki Yasuno; Tetsuro Oshika
Tags: cornea, optical coherence tomography, keratoconus
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3196-3201. doi:https://doi.org/10.1167/iovs.14-16327
Photophobia and Corneal Crystal Density in Nephropathic Cystinosis: An In Vivo Confocal Microscopy and Anterior-Segment Optical Coherence Tomography Study Free
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Hong Liang; Christophe Baudouin; Rachid Tahiri Joutei Hassani; Françoise Brignole-Baudouin; Antoine Labbe
Tags: cornea, crystal structure, photophobia, microscopy, confocal, fanconi syndrome
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3218-3225. doi:https://doi.org/10.1167/iovs.15-16499
Cannabinoid-Induced Chemotaxis in Bovine Corneal Epithelial Cells Free
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Natalia Murataeva; Shimin Li; Olivia Oehler; Sally Miller; Amey Dhopeshwarkar; Sherry Shu-Jung Hu; Joseph A. Bonanno; Heather Bradshaw; Ken Mackie; Douglas McHugh; Alex Straiker
Tags: cannabinoids, cattle, chemotaxis, corneal epithelial cells, signal transduction
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3304-3313. doi:https://doi.org/10.1167/iovs.14-15675
Corneal Sensitivity Following Lacrimal Gland Excision in the Rat Free
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Ian D. Meng; Stephen T. Barton; Neal E. Mecum; Masayuki Kurose
Tags: blinking, cornea, excision, eye, lacrimal gland
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3347-3354. doi:https://doi.org/10.1167/iovs.15-16717
Hyperglycemia-Suppressed Expression of Serpine1 Contributes to Delayed Epithelial Wound Healing in Diabetic Mouse Corneas Free
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Haijing Sun; Xiaofan Mi; Nan Gao; Chenxi Yan; Fu-Shin Yu
Tags: cornea, diabetes mellitus, epithelium, hyperglycemia, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3383-3392. doi:https://doi.org/10.1167/iovs.15-16606

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Optical Coherence Tomography Study of Retinal Changes in Normal Aging and After Ischemia Free
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Mohammad Ali Shariati; Joyce Ho Park; Yaping Joyce Liao
Tags: aging, ischemia, mice, optic neuropathy, ischemic, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2790-2797. doi:https://doi.org/10.1167/iovs.14-15145
Cross-Coupled Eye Movement Supports Neural Origin of Pattern Strabismus Free
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Fatema F. Ghasia; Aasef G. Shaikh; Jonathan Jacobs; Mark F. Walker
Tags: eye, eye movement, saccades, strabismus, torsion
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2855-2866. doi:https://doi.org/10.1167/iovs.15-16371
Automatic Computer-Aided Diagnosis of Retinal Nerve Fiber Layer Defects Using Fundus Photographs in Optic Neuropathy Free
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Ji Eun Oh; Hee Kyung Yang; Kwang Gi Kim; Jeong-Min Hwang
Tags: fundus photography, optic nerve disorders, retinal nerve fiber layer, computer assisted diagnosis
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2872-2879. doi:https://doi.org/10.1167/iovs.14-15096
Negligible Impact on Posture From 5-Diopter Vertical Yoked Prisms Free
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Catherine M. Suttle; Lisa J. Asper; Daina Sturnieks; Jasmine Menant
Tags: diopters, posture, prisms, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2980-2984. doi:https://doi.org/10.1167/iovs.14-15866
Peripapillary Choroidal Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy Free
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Masoud Aghsaei Fard; Parisa Abdi; Abulfazl Kasaei; Reza Soltani Moghadam; Marjan Afzali; Sasan Moghimi
Tags: nonarteritic anterior ischemic optic neuropathy, optic neuropathy, ischemic, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3027-3033. doi:https://doi.org/10.1167/iovs.14-15661
Photographic Reading Center of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT): Methods and Baseline Results Free
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William S. Fischer; Michael Wall; Michael P. McDermott; Mark J. Kupersmith; Steven E. Feldon; for the NORDIC Idiopathic Intracranial Hypertension Study Group
Tags: eye, papilledema, pseudotumor cerebri, reading (activity), edema
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3292-3303. doi:https://doi.org/10.1167/iovs.15-16465

Genetics

Development of Congenital Stromal Corneal Dystrophy Is Dependent on Export and Extracellular Deposition of Truncated Decorin Free
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Anne Elisabeth Christensen Mellgren; Ove Bruland; Anni Vedeler; Jaakko Saraste; Jürgen Schönheit; Cecilie Bredrup; Per Morten Knappskog; Eyvind Rødahl
Tags: body tissue, cornea, mice, stromal dystrophies, corneal, mutation
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2909-2915. doi:https://doi.org/10.1167/iovs.14-16014
Mouse Slc9a8 Mutants Exhibit Retinal Defects Due to Retinal Pigmented Epithelium Dysfunction Free
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Shalini Jadeja; Alun R. Barnard; Lisa McKie; Sally H. Cross; Jacqueline K. White; on behalf of the Sanger Mouse Genetics Project; Morag Robertson; Peter S. Budd; Robert E. MacLaren; Ian J. Jackson
Tags: mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3015-3026. doi:https://doi.org/10.1167/iovs.14-15735

Glaucoma

Chronic Ocular Hypertension Induced by Circumlimbal Suture in Rats Free
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Hsin-Hua Liu; Bang V. Bui; Christine T. O. Nguyen; Jelena M. Kezic; Algis J. Vingrys; Zheng He
Tags: eye, glaucoma, intraocular pressure, ocular hypertension, rats
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2811-2820. doi:https://doi.org/10.1167/iovs.14-16009
Influence of Translaminar Pressure Dynamics on the Position of the Anterior Lamina Cribrosa Surface Free
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Dae Seung Lee; Eun Ji Lee; Tae-Woo Kim; Young Ho Park; Jungeun Kim; Joon Woo Lee; SangYun Kim
Tags: barnes syndrome, cribriform plate, eye, intraocular pressure, optic disk
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2833-2841. doi:https://doi.org/10.1167/iovs.14-15869
Diurnal Intraocular Pressure and the Relationship With Swept-Source OCT–Derived Anterior Chamber Dimensions in Angle Closure: The IMPACT Study Free
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Laura Sanchez-Parra; Shahina Pardhan; Roger J. Buckley; Mike Parker; Rupert R. A. Bourne
Tags: anterior chamber of eye, atrial premature complexes, impact trial, intraocular pressure, primary angle closure suspect
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2943-2949. doi:https://doi.org/10.1167/iovs.14-15385
Lamina Cribrosa Configuration in Tilted Optic Discs With Different Tilt Axes: A New Hypothesis Regarding Optic Disc Tilt and Torsion Free
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Kyoung Min Lee; Eun Ji Lee; Tae-Woo Kim
Tags: eye, optic disk, tilted optic disc, torsion, glaucoma
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2958-2967. doi:https://doi.org/10.1167/iovs.14-15953
Effect of Topical Anesthesia on Episcleral Venous Pressure in Normal Human Subjects Free
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Mehrdad Malihi; Jay W. McLaren; Arthur J. Sit
Tags: anesthesia, topical, topical anesthetics, venous pressure level, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2968-2970. doi:https://doi.org/10.1167/iovs.14-16325
Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye Free
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Wennan Lu; HuiLing Hu; Jean Sévigny; B'Ann T. Gabelt; Paul L. Kaufman; Elaine C. Johnson; John C. Morrison; Gulab S. Zode; Val C. Sheffield; Xiulan Zhang; Alan M. Laties; Claire H. Mitchell
Tags: eye, glaucoma, intraocular pressure, mice, primates
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3075-3083. doi:https://doi.org/10.1167/iovs.14-15891
Structure–Function Relationship Between Bruch's Membrane Opening–Based Optic Nerve Head Parameters and Visual Field Defects in Glaucoma Free
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Daniel R. Muth; Christoph W. Hirneiß
Tags: bruch's basal membrane, glaucoma, optic disk, scotoma, visual field defects
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3320-3328. doi:https://doi.org/10.1167/iovs.14-15845
Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population Free
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Tin A. Tun; Chen-Hsin Sun; Mani Baskaran; Michael J. A. Girard; John Mark S. de Leon; Ching-Yu Cheng; Hla M. Htoon; Tien Y. Wong; Tin Aung; Nicholas G. Strouthidis
Tags: bruch's basal membrane, chinese (other dialects), chinese people, diagnostic imaging, neuroretinal rim
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3337-3344. doi:https://doi.org/10.1167/iovs.15-16786

Immunology and Microbiology

Prevalence of Antiseptic-Resistance Genes in Staphylococci Isolated From Orthokeratology Lens and Spectacle Wearers in Hong Kong Free
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Guang-sen Shi; Maureen Boost; Pauline Cho
Tags: anti-infective agents, local, contact lenses, genes, hong kong, orthokeratology contact lenses
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3069-3074. doi:https://doi.org/10.1167/iovs.15-16550
Involvement of Corneal Lymphangiogenesis in a Mouse Model of Allergic Eye Disease Free
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Hyun-Soo Lee; Deniz Hos; Tomas Blanco; Felix Bock; Nancy J. Reyes; Rose Mathew; Claus Cursiefen; Reza Dana; Daniel R. Saban
Tags: cornea, eye diseases, immediate hypersensitivity, lymphangiogenesis, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3140-3148. doi:https://doi.org/10.1167/iovs.14-16186

Lens

Experimental Protocols for Ex Vivo Lens Stretching Tests to Investigate the Biomechanics of the Human Accommodation Apparatus Free
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Laura Pinilla Cortés; Harvey John Burd; Gustavo A. Montenegro; Justin Christopher D'Antin; Marek Mikielewicz; Rafael I. Barraquer; Ralph Michael
Tags: ciliary body, lens (device), lens, crystalline, stretching exercises, visual accommodation
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2926-2932. doi:https://doi.org/10.1167/iovs.14-15744
Increased Levels of Inflammatory Immune Mediators in Vitreous From Pseudophakic Eyes Free
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Gunnar Jakobsson; Karin Sundelin; Henrik Zetterberg; Madeleine Zetterberg
Tags: biological response modifiers, eye, immune mediator, vitreous body
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3407-3414. doi:https://doi.org/10.1167/iovs.15-16837

Low Vision

Assessing the Effectiveness of Low Vision Rehabilitation in Children: An Observational Study Free
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Vijaya K. Gothwal; Rebecca Sumalini; Seelam Bharani
Tags: blind rehabilitation therapy, child, vision
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3355-3360. doi:https://doi.org/10.1167/iovs.14-15760

Multidisciplinary Ophthalmic Imaging

Optimal Number of Angle Images for Calculating Anterior Angle Volume and Iris Volume Measurements Free
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Lauren S. Blieden; Alice Z. Chuang; Laura A. Baker; Nicholas P. Bell; Timothy S. Fuller; Kimberly A. Mankiewicz; Robert M. Feldman
Tags: immune reconstitution inflammatory syndrome, iris, volume, measurement error, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2842-2847. doi:https://doi.org/10.1167/iovs.14-15883
Noninvasive Vascular Imaging of Polypoidal Choroidal Vasculopathy by Doppler Optical Coherence Tomography Free
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Masahiro Miura; Daisuke Muramatsu; Young-Joo Hong; Yoshiaki Yasuno; Takuya Iwasaki; Hiroshi Goto
Tags: diagnostic imaging, optical coherence tomography, vascular diseases
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3179-3186. doi:https://doi.org/10.1167/iovs.14-16252
Fluorescence Lifetime Imaging in Retinal Artery Occlusion Free
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Chantal Dysli; Sebastian Wolf; Martin S. Zinkernagel
Tags: diagnostic imaging, fluorescence, retinal artery occlusion
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3329-3336. doi:https://doi.org/10.1167/iovs.14-16203

Physiology and Pharmacology

Role of Neuronal Nitric Oxide Synthase in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats Free
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Takafumi Yoshioka; Taiji Nagaoka; Youngseok Song; Harumasa Yokota; Tomofumi Tani; Akitoshi Yoshida
Tags: cats, nitric oxide synthase, photopsia, erythema, adaptive testing
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3113-3120. doi:https://doi.org/10.1167/iovs.14-15854

Retina

Effect of Internal Limiting Membrane Abrasion on Retinal Tissues in Macular Holes Free
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David R. P. Almeida; Eric K. Chin; Ryan M. Tarantola; James C. Folk; H. Culver Boldt; Jessica M. Skeie; Robert F. Mullins; Stephen R. Russell; Vinit B. Mahajan
Tags: abrasion, body tissue, macular holes, tissue membrane, surgical procedures, operative
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2783-2789. doi:https://doi.org/10.1167/iovs.14-16355
Retinal Oxygen Saturation in Retinitis Pigmentosa and Macular Dystrophies in Asian-Indian Eyes Free
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Rajani Battu; Ashwin Mohan; Anjani Khanna; Abhinav Kumar; Rohit Shetty
Tags: asian indians, eye, macular dystrophy, oximetry, oxygen saturation measurement
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2798-2802. doi:https://doi.org/10.1167/iovs.14-15993
Progesterone Treatment in Two Rat Models of Ocular Ischemia Free
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Rachael S. Allen; Timothy W. Olsen; Iqbal Sayeed; Heather A. Cale; Katherine C. Morrison; Yuliya Oumarbaeva; Irina Lucaciu; Jeffrey H. Boatright; Machelle T. Pardue; Donald G. Stein
Tags: middle cerebral artery occlusion, progesterone, progestogen hormone therapy, rats, retinal ischemia
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2880-2891. doi:https://doi.org/10.1167/iovs.14-16070
Advanced Glycation End-Product Accumulation Reduces Vitreous Permeability Free
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On-Tat Lee; Samuel D. Good; Ricardo Lamy; Max Kudisch; Jay M. Stewart
Tags: glycation, permeability, vitreous body, diffusion
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2892-2897. doi:https://doi.org/10.1167/iovs.14-15840
Changes in Retinochoroidal Thickness After Vitrectomy for Proliferative Diabetic Retinopathy Free
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Kentaro Yamamoto; Takeshi Iwase; Hiroaki Ushida; Tadasu Sugita; Hiroko Terasaki
Tags: choroidal detachment, light coagulation, proliferative diabetic retinopathy, surgical procedures, operative, vitrectomy
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3034-3040. doi:https://doi.org/10.1167/iovs.14-15981
High-Fat Diet Induces Toll-Like Receptor 4-Dependent Macrophage/Microglial Cell Activation and Retinal Impairment Free
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Jong-Jer Lee; Pei-Wen Wang; I-Hui Yang; Hsiu-Mei Huang; Chia-Shiang Chang; Chia-Lin Wu; Jiin-Haur Chuang
Tags: diet, macrophages, mice, retina, toll-like receptor 4
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3041-3050. doi:https://doi.org/10.1167/iovs.15-16504
Catalase Therapy Corrects Oxidative Stress-Induced Pathophysiology in Incipient Diabetic Retinopathy Free
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Courtney R. Giordano; Robin Roberts; Kendra A. Krentz; David Bissig; Deepa Talreja; Ashok Kumar; Stanley R. Terlecky; Bruce A. Berkowitz
Tags: adaptive testing, catalase, cats, chloramphenicol o-acetyltransferase, computed tomography
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3095-3102. doi:https://doi.org/10.1167/iovs.14-16194
Quantitative Fundus Autofluorescence and Optical Coherence Tomography in PRPH2/RDS- and ABCA4-Associated Disease Exhibiting Phenotypic Overlap Free
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Tobias Duncker; Stephen H. Tsang; Russell L. Woods; Winston Lee; Jana Zernant; Rando Allikmets; François C. Delori; Janet R. Sparrow
Tags: fundus autofluorescence imaging, mutation, optical coherence tomography, phenotype, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3159-3170. doi:https://doi.org/10.1167/iovs.14-16343
Toward a Specific Classification of Polypoidal Choroidal Vasculopathy: Idiopathic Disease or Subtype of Age-Related Macular Degeneration Free
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Gabriel Coscas; Marco Lupidi; Florence Coscas; Fayçal Benjelloun; Jennifer Zerbib; Ali Dirani; Oudy Semoun; Eric H. Souied
Tags: age-related macular degeneration, choroidal neovascularization, polyps, vascular diseases, diagnostic imaging
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3187-3195. doi:https://doi.org/10.1167/iovs.14-16236
Validity of Automated Choroidal Segmentation in SS-OCT and SD-OCT Free
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Li Zhang; Gabriëlle H. S. Buitendijk; Kyungmoo Lee; Milan Sonka; Henriët Springelkamp; Albert Hofman; Johannes R. Vingerling; Robert F. Mullins; Caroline C. W. Klaver; Michael D. Abràmoff
Tags: choroid, graphical displays, validity of results, absolute risk reduction, vasculature
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3202-3211. doi:https://doi.org/10.1167/iovs.14-15669
Macular Perfusion in Healthy Chinese: An Optical Coherence Tomography Angiogram Study Free
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Jian Yu; Chunhui Jiang; Xiaolei Wang; Li Zhu; Ruiping Gu; Huan Xu; Yali Jia; David Huang; Xinghuai Sun
Tags: angiogram, chinese (other dialects), chinese people, fluid flow, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3212-3217. doi:https://doi.org/10.1167/iovs.14-16270
Near-Infrared Autofluorescence: Its Relationship to Short-Wavelength Autofluorescence and Optical Coherence Tomography in Recessive Stargardt Disease Free
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Vivienne C. Greenstein; Ari D. Schuman; Winston Lee; Tobias Duncker; Jana Zernant; Rando Allikmets; Donald C. Hood; Janet R. Sparrow
Tags: autofluorescence, optical coherence tomography, stargardt's disease, maps, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3226-3234. doi:https://doi.org/10.1167/iovs.14-16050
The Project MACULA Retinal Pigment Epithelium Grading System for Histology and Optical Coherence Tomography in Age-Related Macular Degeneration Free
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Emma C. Zanzottera; Jeffrey D. Messinger; Thomas Ach; R. Theodore Smith; K. Bailey Freund; Christine A. Curcio
Tags: age-related macular degeneration, choroidal neovascularization, eye, grading system, granules
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3253-3268. doi:https://doi.org/10.1167/iovs.15-16431
Subducted and Melanotic Cells in Advanced Age-Related Macular Degeneration Are Derived From Retinal Pigment Epithelium Free
PDF
Emma C. Zanzottera; Jeffrey D. Messinger; Thomas Ach; R. Theodore Smith; Christine A. Curcio
Tags: age-related macular degeneration, biological response modifiers, cell transdifferentiation, choroidal neovascularization, eye
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3269-3278. doi:https://doi.org/10.1167/iovs.15-16432
Systemic Counterregulatory Response of Placental Growth Factor Levels to Intravitreal Aflibercept Therapy Free
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Claus Zehetner; Nikolaos E. Bechrakis; Martin Stattin; Rudolf Kirchmair; Hanno Ulmer; Martina T. Kralinger; Gerhard F. Kieselbach
Tags: aflibercept, placenta growth factor, up-regulation (physiology), vascular endothelial growth factor a, vascular endothelial growth factor b
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3279-3286. doi:https://doi.org/10.1167/iovs.15-16686
Optical Coherence Tomography Angiography of
Peripapillary Retinal Blood Flow Response to Hyperoxia Free
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Alex D. Pechauer; Yali Jia; Liang Liu; Simon S. Gao; Chunhui Jiang; David Huang
Tags: angiogram, hyperoxia, optical coherence tomography, vascular flow, fluid flow
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3287-3291. doi:https://doi.org/10.1167/iovs.15-16655
In Vitro Modeling of Emulsification of Silicone Oil as Intraocular Tamponade Using Microengineered Eye-on-a-Chip Free
PDF
Yau Kei Chan; Kwun Hei Samuel Sy; Chun Yu Wong; Ping Kwan Man; David Wong; Ho Cheung Shum
Tags: emulsification, eye, eye movement, silicone oils
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3314-3319. doi:https://doi.org/10.1167/iovs.15-16728
Autofluorescence Imaging With Near-Infrared Excitation:
Normalization by Reflectance to Reduce Signal From Choroidal Fluorophores Free
PDF
Artur V. Cideciyan; Malgorzata Swider; Samuel G. Jacobson
Tags: atrophy, autofluorescence, diagnostic imaging, excitation, melanins
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3393-3406. doi:https://doi.org/10.1167/iovs.15-16726
Localization of Damage in Progressive Hydroxychloroquine Retinopathy On and Off the Drug: Inner Versus Outer Retina, Parafovea Versus Peripheral Fovea Free
PDF
Luis de Sisternes; Julia Hu; Daniel L. Rubin; Michael F. Marmor
Tags: fovea centralis, hydroxychloroquine, retina, retinal diseases, toxic effect
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3415-3426. doi:https://doi.org/10.1167/iovs.14-16345

Retinal Cell Biology

Glutaredoxin 1 (Grx1) Protects Human Retinal Pigment Epithelial Cells From Oxidative Damage by Preventing AKT Glutathionylation Free
PDF
Xiaobin Liu; Jamieson Jann; Christy Xavier; Hongli Wu
Tags: protein overexpression, proteins, proto-oncogene proteins c-akt, retinal pigment cell, opportunity for error
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2821-2832. doi:https://doi.org/10.1167/iovs.14-15876
Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation Free
PDF
Shuai Wang; Shanshan Du; Qiang Wu; Jianyan Hu; Tingting Li
Tags: diabetes mellitus, epithelium, glucose, hypoxia, mitogen-activated protein kinase p38
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2971-2979. doi:https://doi.org/10.1167/iovs.14-15874
Lipotoxicity Augments Glucotoxicity-Induced Mitochondrial Damage in the Development of Diabetic Retinopathy Free
PDF
Binit Kumar; Anjan Kowluru; Renu A. Kowluru
Tags: ceramides, cybb gene, diabetic retinopathy, dna, mitochondrial, endothelial cells
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2985-2992. doi:https://doi.org/10.1167/iovs.15-16466
Genetic Dissection of Horizontal Cell Inhibitory Signaling in Mice in Complete Darkness In Vivo Free
PDF
Bruce A. Berkowitz; Geoffrey G. Murphy; Cheryl Mae Craft; D. James Surmeier; Robin Roberts
Tags: darkness, genetics, horizontal cells, manganese, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3132-3139. doi:https://doi.org/10.1167/iovs.15-16581
Lipofuscin Redistribution and Loss Accompanied by Cytoskeletal Stress in Retinal Pigment Epithelium of Eyes With Age-Related Macular Degeneration Free
PDF
Thomas Ach; Elen Tolstik; Jeffrey D. Messinger; Anna V. Zarubina; Rainer Heintzmann; Christine A. Curcio
Tags: age-related macular degeneration, cytoskeleton, eye, granules, lipofuscin
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3242-3252. doi:https://doi.org/10.1167/iovs.14-16274
Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish Free
PDF
Soo Young Choi; Jeong-In Baek; Xiaofeng Zuo; Seok-Hyung Kim; Joshua L. Dunaief; Joshua H. Lipschutz
Tags: cdc42 gtp-binding protein, zebrafish
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3361-3370. doi:https://doi.org/10.1167/iovs.14-15692

Visual Psychophysics and Physiological Optics

Flicker Adaptation Desensitizes the Magnocellular but Not the Parvocellular Pathway Free
PDF
Xiaohua Zhuang; Joel Pokorny; Dingcai Cao
Tags: photopsia, luminance, psychophysics
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2901-2908. doi:https://doi.org/10.1167/iovs.14-16067
What You See Is What You Step: The Horizontal–Vertical Illusion Increases Toe Clearance in Older Adults During Stair Ascent Free
PDF
Richard J. Foster; David Whitaker; Andrew J. Scally; John G. Buckley; David B. Elliott
Tags: ascending stairs, drug clearance, illusions, older adult, safety
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2950-2957. doi:https://doi.org/10.1167/iovs.14-16018

New Developments in Vision Research

Performance on the Farnsworth-Munsell 100-Hue Test Is Significantly Related to Nonverbal IQ Free
PDF
Matthew B. Cranwell; Bradley Pearce; Camilla Loveridge; Anya C. Hurlbert
Tags: adult, autism spectrum disorder, child, color, luminance
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3171-3178. doi:https://doi.org/10.1167/iovs.14-16094

Research Opportunities

Aqueous Humor Outflow: Dynamics and Disease Free
PDF
Uttio Roy Chowdhury; Cheryl R. Hann; W. Daniel Stamer; Michael P. Fautsch
Tags: aqueous humor, extracellular matrix, glaucoma, intraocular pressure, mice
Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2993-3003. doi:https://doi.org/10.1167/iovs.15-16744

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science May 2015, Vol.56, 2916. doi:https://doi.org/10.1167/iovs.14-14809a
Erratum Free
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Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3345. doi:https://doi.org/10.1167/iovs.14-15531a
Erratum Free
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Investigative Ophthalmology & Visual Science May 2015, Vol.56, 3346. doi:https://doi.org/10.1167/iovs.14-15447a
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