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Research Highlight

An Assessment of Dynamic Retinal Microvascular Changes in Healthy Subjects Free
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Louis R. Pasquale
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3997. doi:https://doi.org/10.1167/iovs.15-17309
Two Subtypes of Polypoidal Choroidal Vasculopathy: Idiopathic Disease or Age-Related Macular Degeneration Free
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Mitsuko Yuzawa
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3998. doi:https://doi.org/10.1167/iovs.15-17207

Anatomy and Pathology/Oncology

High-Resolution Array CGH Analysis Identifies Regional Deletions and Amplifications of Chromosome 8 in Uveal Melanoma Free
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David W. Hammond; Nawal S. D. Al-Shammari; Sarah Danson; Rhona Jacques; Ian G. Rennie; Karen Sisley
Tags: chromosomes, human, pair 8, uveal melanoma
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3460-3466. doi:https://doi.org/10.1167/iovs.14-16215
Paraxial Schematic Eye Models for 7- and 14-Year-Old Chinese Children Free
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Shi-Ming Li; Ningli Wang; Yuehua Zhou; Si-Yuan Li; Meng-Tian Kang; Luo-Ru Liu; He Li; Yun-Yun Sun; Bo Meng; Si-Yan Zhan; David A. Atchison
Tags: child, chinese (other dialects), chinese people, eye, lens (device)
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3577-3583. doi:https://doi.org/10.1167/iovs.15-16428
Peripapillary Choroidal Thickness in Adult Chinese: The Beijing Eye Study Free
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Ran Jiang; Ya Xing Wang; Wen Bin Wei; Liang Xu; Jost B. Jonas
Tags: adult, chinese (other dialects), chinese people, eye, visual acuity
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4045-4052. doi:https://doi.org/10.1167/iovs.15-16521
Genome-Wide Analysis of Ocular Adnexal Lymphoproliferative Disorders Using High-Resolution Single Nucleotide Polymorphism Array Free
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Hiroki Takahashi; Yoshihiko Usui; Shunichiro Ueda; Naoyuki Yamakawa; Aiko Sato-Otsubo; Yusuke Sato; Seishi Ogawa; Hiroshi Goto
Tags: genome-wide association study, lymphoma, mucosa-associated lymphoid tissue, lymphoproliferative disorders, single nucleotide polymorphism, conjunctiva
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4156-4165. doi:https://doi.org/10.1167/iovs.15-16382

Biochemistry and Molecular Biology

Unique Variants in OPN1LW Cause Both Syndromic and Nonsyndromic X-Linked High Myopia Mapped to MYP1 Free
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Jiali Li; Bei Gao; Liping Guan; Xueshan Xiao; Jianguo Zhang; Shiqiang Li; Hui Jiang; Xiaoyun Jia; Jianhua Yang; Xiangming Guo; Ye Yin; Jun Wang; Qingjiong Zhang
Tags: myopia, x-linked inheritance, family, haplotypes
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4150-4155. doi:https://doi.org/10.1167/iovs.14-16356

Clinical and Epidemiologic Research

Prevalence of Optic Disc Hemorrhage in Korea: The Korea National Health and Nutrition Examination Survey Free
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Dai Woo Kim; Young Kook Kim; Jin Wook Jeoung; Dong Myung Kim; Ki Ho Park; for the Epidemiologic Survey Committee of the Korean Ophthalmological Society
Tags: eye, glaucoma, hemorrhage, korea, national health and nutrition examination survey
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3666-3672. doi:https://doi.org/10.1167/iovs.14-16319
Aqueous Humor Biomarkers of Müller Cell Activation in Diabetic Eyes Free
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Stela Vujosevic; Alessandra Micera; Silvia Bini; Marianna Berton; Graziana Esposito; Edoardo Midena
Tags: aquaporin 1, aqueous humor, biological markers, diabetes mellitus, eye
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3913-3918. doi:https://doi.org/10.1167/iovs.15-16554
Associations Between Topical Ophthalmic Corticosteroids and Central Serous Chorioretinopathy: A Taiwanese Population-Based Study Free
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Yuh-Shin Chang; Shih-Feng Weng; Chun Chang; Jhi-Joung Wang; Jiu-Yao Wang; Ren-Long Jan
Tags: adrenal corticosteroids, central serous chorioretinopathy, eye, glucocorticoids, mineralocorticoids
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4083-4089. doi:https://doi.org/10.1167/iovs.14-16360

Cornea

The PEDF Neuroprotective Domain Plus DHA Induces Corneal Nerve Regeneration After Experimental Surgery Free
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Jiucheng He; M. Soledad Cortina; Azucena Kakazu; Haydee E. P. Bazan
Tags: cornea, nerve regeneration, oryctolagus cuniculus, surgical procedures, operative
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3505-3513. doi:https://doi.org/10.1167/iovs.15-16755
Functional Limbal Epithelial Cells Can Be Successfully Isolated From Organ Culture Rims Following Long-Term Storage Free
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Victoria E. Tovell; Isobel Massie; Alvena K. Kureshi; Julie T. Daniels
Tags: epithelial cells, organ culture techniques, patient isolation, social isolation, oculocerebrocutaneous syndrome
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3531-3540. doi:https://doi.org/10.1167/iovs.14-15429
Spatiotemporally Regulated Ablation of Klf4 in Adult Mouse Corneal Epithelial Cells Results in Altered Epithelial Cell Identity and Disrupted Homeostasis Free
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Emili E. Delp; Sudha Swamynathan; Winston W. Kao; Shivalingappa K. Swamynathan
Tags: ablation, adult, cornea, corneal epithelial cells, epithelial cells
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3549-3558. doi:https://doi.org/10.1167/iovs.15-16463
Changes in Matrix Metalloproteinases in Diabetes Patients' Tears After Vitrectomy and the Relationship With Corneal Epithelial Disorder Free
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Takehiro Matsumura; Yoshihiro Takamura; Takeshi Tomomatsu; Shogo Arimura; Makoto Gozawa; Yuji Takihara; Masaru Inatani
Tags: cornea, diabetes mellitus, diabetes mellitus, type 2, epithelium, matrix metalloproteinases
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3559-3564. doi:https://doi.org/10.1167/iovs.15-16489
The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells Free
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Cui Li; Guiqiu Zhao; Chengye Che; Jing Lin; Na Li; Liting Hu; Nan Jiang; Ying Liu
Tags: aspergillus fumigatus, chemokine (c-x-c motif) ligand 1, corneal epithelial cells, corneal epithelium, immunity, natural
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3593-3603. doi:https://doi.org/10.1167/iovs.14-15989
MicroRNA Expression Profile and the Role of miR-204 in Corneal Wound Healing Free
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Jianhong An; Xiaoyan Chen; Weiwei Chen; Rongxin Liang; Peter S. Reinach; Dongsheng Yan; LiLi Tu
Tags: cornea, micrornas, wound healing, epithelium, mice
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3673-3683. doi:https://doi.org/10.1167/iovs.15-16467
Femtosecond Laser-Assisted Corneal Small Incision Allogenic Intrastromal Lenticule Implantation in Monkeys: A Pilot Study Free
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Rui Liu; Jing Zhao; Ye Xu; Meiyan Li; Lingling Niu; Huiying Liu; Ling Sun; Renyuan Chu; Xingtao Zhou
Tags: cercopithecidae, cornea, implantation procedure, lasers, pilot projects
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3715-3720. doi:https://doi.org/10.1167/iovs.14-15296
Existence of Corneal Endothelial Slow-Cycling Cells Free
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Edgar M. Espana; Mei Sun; David E. Birk
Tags: cornea, endothelium, ngfr protein
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3827-3837. doi:https://doi.org/10.1167/iovs.14-16030
Multiscale Investigation of the Depth-Dependent Mechanical Anisotropy of the Human Corneal Stroma Free
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Cristina Labate; Marco Lombardo; Maria P. De Santo; Janice Dias; Noel M. Ziebarth; Giuseppe Lombardo
Tags: anisotropy, body tissue, cornea, corneal stroma, elasticity
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4053-4060. doi:https://doi.org/10.1167/iovs.15-16875
iTRAQ-Based Quantitative Proteomic Analysis of Tear Fluid in a Rat Penetrating Keratoplasty Model With Acute Corneal Allograft Rejection Free
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Feifei Huang; Jianjiang Xu; Hong Jin; Jianwen Tan; Chaoran Zhang
Tags: allografting, cornea, proteins, rejection (psychology), keratoplasty, penetrating
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4117-4124. doi:https://doi.org/10.1167/iovs.14-16207

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Adaptation of Slow Myofibers: The Effect of Sustained BDNF Treatment of Extraocular Muscles in Infant Nonhuman Primates Free
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Christy L. Willoughby; Jérome Fleuriet; Mark M. Walton; Michael J. Mustari; Linda K. McLoon
Tags: brain-derived neurotrophic factor, cercopithecidae, infant, neuromuscular junction
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3467-3483. doi:https://doi.org/10.1167/iovs.15-16852
Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment Free
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Christy L. Willoughby; Jérome Fleuriet; Mark M. Walton; Michael J. Mustari; Linda K. McLoon
Tags: cercopithecidae, insulin-like growth factor i, medial rectus muscle, muscle, strabismus
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3484-3496. doi:https://doi.org/10.1167/iovs.15-16761
Relationship Between Pattern Electroretinogram, Frequency-Domain OCT, and Automated Perimetry in Chronic Papilledema From Pseudotumor Cerebri Syndrome Free
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Clara L. Afonso; Ali S. Raza; André C. Kreuz; Kenzo Hokazono; Leonardo P. Cunha; Maria K. Oyamada; Mário L. R. Monteiro
Tags: electroretinography, papilledema, perimetry, pseudotumor cerebri, eye
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3656-3665. doi:https://doi.org/10.1167/iovs.15-16768
Pathological Involvement of Astrocyte-Derived Lipocalin-2 in the Demyelinating Optic Neuritis Free
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Bo Young Chun; Jong-Heon Kim; Youngpyo Nam; Man-Il Huh; Seungwoo Han; Kyoungho Suk
Tags: astrocytes, mice, optic nerve, optic neuritis, plasma
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3691-3698. doi:https://doi.org/10.1167/iovs.15-16851
Adaptation to Laterally Displacing Prisms in Anisometropic Amblyopia Free
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Jaime C. Sklar; Herbert C. Goltz; Luke Gane; Agnes M. F. Wong
Tags: amblyopia, prisms, heterogeneity of variance, time factors
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3699-3708. doi:https://doi.org/10.1167/iovs.15-16605
The Photopic Negative Response in Idiopathic Intracranial Hypertension Free
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Heather E. Moss; Jason C. Park; J. Jason McAnany
Tags: papilledema, pseudotumor cerebri, vision
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3709-3714. doi:https://doi.org/10.1167/iovs.15-16586
Causes and Prognosis of Visual Acuity Loss at the Time of Initial Presentation in Idiopathic Intracranial Hypertension Free
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John J. Chen; Matthew J. Thurtell; Reid A. Longmuir; Mona K. Garvin; Jui-Kai Wang; Michael Wall; Randy H. Kardon
Tags: blindness, eye, optic nerve disorders, pseudotumor cerebri, reduced visual acuity
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3850-3859. doi:https://doi.org/10.1167/iovs.15-16450

Genetics

Comprehensive Molecular Diagnosis of a Large Chinese Leber Congenital Amaurosis Cohort Free
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Hui Wang; Xia Wang; Xuan Zou; Shan Xu; Hui Li; Zachry Tore Soens; Keqing Wang; Yumei Li; Fangtian Dong; Rui Chen; Ruifang Sui
Tags: chinese (other dialects), cohort studies, family, genes, molecular diagnostic techniques
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3642-3655. doi:https://doi.org/10.1167/iovs.14-15972
A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia Free
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Dennis M. Maddox; Gayle B. Collin; Akihiro Ikeda; C. Herbert Pratt; Sakae Ikeda; Britt A. Johnson; Ron E. Hurd; Lindsay S. Shopland; Jürgen K. Naggert; Bo Chang; Mark P. Krebs; Patsy M. Nishina
Tags: electroretinography, homozygote, mice, mutation, neuroglia
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3776-3787. doi:https://doi.org/10.1167/iovs.14-16047
ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement Free
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Mingchu Xu; Violet Gelowani; Aiden Eblimit; Feng Wang; Marielle P. Young; Briana L. Sawyer; Li Zhao; Glen Jenkins; Donnell J. Creel; Keqing Wang; Zhongqi Ge; Hui Wang; Yumei Li; M. Elizabeth Hartnett; Rui Chen
Tags: mutation, photoreceptors, tissue degeneration, proteins, genes
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3889-3895. doi:https://doi.org/10.1167/iovs.15-16778
A De Novo Mutation in TEAD1 Causes Non–X-Linked Aicardi Syndrome Free
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Isabelle Schrauwen; Szabolcs Szelinger; Ashley L. Siniard; Jason J. Corneveaux; Ahmet Kurdoglu; Ryan Richholt; Matt De Both; Ivana Malenica; Shanker Swaminathan; Sampathkumar Rangasamy; Neil Kulkarni; Saunder Bernes; Jeffrey Buchhalter; Keri Ramsey; David W. Craig; Vinodh Narayanan; Matthew J. Huentelman
Tags: aicardi syndrome, de novo mutation, genes, mutation, rna
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3896-3904. doi:https://doi.org/10.1167/iovs.14-16261
The Heritability of Corneal and Ocular Higher-Order Aberrations in Koreans: The Healthy Twin Study Free
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Dong Hui Lim; Woori Kim; Gyule Han; Gi Hyun Bae; Myung Hun Kim; Myoung Joon Kim; Yun-Mi Song; Eui-Sang Chung; Tae-Young Chung; Joohon Sung; for the Korean Healthy Twin Study
Tags: cornea, eye, twin studies, genetics
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3919-3928. doi:https://doi.org/10.1167/iovs.14-15763

Glaucoma

Imaging Glaucomatous Damage Across the Temporal Raphe Free
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Gang Huang; Ting Luo; Thomas J. Gast; Stephen A. Burns; Victor E. Malinovsky; William H. Swanson
Tags: diagnostic imaging, glaucoma, retinal nerve fiber layer, eye, visual fields
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3496-3504. doi:https://doi.org/10.1167/iovs.15-16730
Simultaneous Increase in Multiple Proinflammatory Cytokines in the Aqueous Humor in Neovascular Glaucoma With and Without Intravitreal Bevacizumab Injection Free
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Saori Ohira; Toshihiro Inoue; Kohei Shobayashi; Keiichiro Iwao; Mikiko Fukushima; Hidenobu Tanihara
Tags: aqueous humor, bevacizumab, cytokine, glaucoma, neovascular, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3541-3548. doi:https://doi.org/10.1167/iovs.14-15918
A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes Free
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Sri Gowtham Thakku; Yih-Chung Tham; Mani Baskaran; Jean-Martial Mari; Nicholas G. Strouthidis; Tin Aung; Ching-Yu Cheng; Michael J. A. Girard
Tags: cribriform plate, eye, language morphology, morphology, optic disk
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3604-3614. doi:https://doi.org/10.1167/iovs.15-16707
Progression to Legal Blindness in Patients With Normal Tension Glaucoma: Hospital-Based Study Free
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Akira Sawada; Jonathan A. Rivera; Daisuke Takagi; Takashi Nishida; Tetsuya Yamamoto
Tags: blindness, glaucoma, low tension glaucoma, visual impairment, hospitals
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3635-3641. doi:https://doi.org/10.1167/iovs.14-16093
Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular Meshwork Free
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Lisa J. Hill; Ben Mead; Richard J. Blanch; Zubair Ahmed; Felicity De Cogan; Peter J. Morgan-Warren; Shabbir Mohamed; Wendy Leadbeater; Robert A. H. Scott; Martin Berry; Ann Logan
Tags: fibrosis, intraocular pressure, rodentia, trabecular meshwork, cicatrix
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3743-3757. doi:https://doi.org/10.1167/iovs.14-15622
DNA Methylation Analysis of Human Trabecular Meshwork Cells During Dexamethasone Stimulation Free
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Akira Matsuda; Yosuke Asada; Kanae Takakuwa; Jobu Sugita; Akira Murakami; Nobuyuki Ebihara
Tags: deoxycytidine, dexamethasone, dna, dna methylation, gene expression
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3801-3809. doi:https://doi.org/10.1167/iovs.14-16008
Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues Free
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Joseph C. Peters; Sanjoy Bhattacharya; Abbot F. Clark; Gulab S. Zode
Tags: body tissue, glaucoma, stress, endoplasmic reticulum, trabecular meshwork
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3860-3868. doi:https://doi.org/10.1167/iovs.14-16220
Time Spent in Lateral Sleep Position and Asymmetry in Glaucoma Free
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Kevin Kaplowitz; Sonya Blizzard; Daniel J. Blizzard; Eberechi Nwogu; Cecily E. Hamill; Robert N. Weinreb; Vahid Mohsenin; Nils A. Loewen
Tags: glaucoma, sleep
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3869-3874. doi:https://doi.org/10.1167/iovs.14-16079
Normal Value Ranges for Central Retinal Thickness Asymmetry in Healthy Caucasian Adults Measured by SPECTRALIS SD-OCT Posterior Pole Asymmetry Analysis Free
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Agnes Galbo Jacobsen; Mette Dahl Bendtsen; Henrik Vorum; Martin Bøgsted; Janos Hargitai
Tags: adult, european continental ancestry group, eye, glaucoma, macula densa
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3875-3882. doi:https://doi.org/10.1167/iovs.14-15663
Structure–Function Relationship in Glaucoma Using Ganglion Cell–Inner Plexiform Layer Thickness Measurements Free
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Harsha L. Rao; Muhammad Qasim; Raza S. M. Hussain; Manideepak Januwada; Lalitha N. Pillutla; Viquar U. Begum; Aditya Chaitanya; Sirisha Senthil; Chandra S. Garudadri
Tags: ganglia, glaucoma, macula densa, macula lutea
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3883-3888. doi:https://doi.org/10.1167/iovs.15-16943
Noncontact Screening Methods for the Detection of Narrow Anterior Chamber Angles Free
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Priya L. Dabasia; David F. Edgar; Ian E. Murdoch; John G. Lawrenson
Tags: acas trial, anterior chamber of eye, diagnostic imaging, eye, gonioscopy
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3929-3935. doi:https://doi.org/10.1167/iovs.15-16727
Relating Retinal Ganglion Cell Function and Retinal Nerve Fiber Layer (RNFL) Retardance to Progressive Loss of RNFL Thickness and Optic Nerve Axons in Experimental Glaucoma Free
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Brad Fortune; Grant Cull; Juan Reynaud; Lin Wang; Claude F. Burgoyne
Tags: axon, glaucoma, optic nerve, retinal ganglion cells, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3936-3944. doi:https://doi.org/10.1167/iovs.15-16548
Artificial Neural Network Approach for Differentiating Open-Angle Glaucoma From Glaucoma Suspect Without a Visual Field Test Free
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Ein Oh; Tae Keun Yoo; Samin Hong
Tags: glaucoma, open-angle glaucoma, visual field testing
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3957-3966. doi:https://doi.org/10.1167/iovs.15-16805
How Many Visual Fields Are Required to Precisely Predict Future Test Results in Glaucoma Patients When Using Different Trend Analyses? Free
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Yukako Taketani; Hiroshi Murata; Yuri Fujino; Chihiro Mayama; Ryo Asaoka
Tags: glaucoma, laboratory test finding, regression analysis, trend, visual fields
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4076-4082. doi:https://doi.org/10.1167/iovs.14-16341
Regulation of Endothelin-1–Induced Trabecular Meshwork Cell Contractility by Latanoprostene Bunod Free
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Megan E. Cavet; Thomas R. Vollmer; Karen L. Harrington; Karl VanDerMeid; Mary E. Richardson
Tags: endothelin-1, latanoprost, trabecular meshwork, cyclic gmp, regulation
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4108-4116. doi:https://doi.org/10.1167/iovs.14-16015

Immunology and Microbiology

Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils Free
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Derek J. Royer; Min Zheng; Christopher D. Conrady; Daniel J. J. Carr
Tags: cornea, human herpesvirus 1, infections, mice, neutrophils
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3763-3775. doi:https://doi.org/10.1167/iovs.15-16900
A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model Free
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Ruchi Srivastava; Arif A. Khan; Jiawei Huang; Anthony B. Nesburn; Steven L. Wechsler; Lbachir BenMohamed
Tags: epitopes, human herpesvirus 1, human leukocyte antigens, keratitis, herpetic, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4013-4028. doi:https://doi.org/10.1167/iovs.15-17074

Lens

Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation Free
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Yuki Sugiyama; Elizabeth J. Shelley; Caroline Badouel; Helen McNeill; John W. McAvoy
Tags: atypical, cadherins, epithelium, lens (device), lens epithelial cell
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4099-4107. doi:https://doi.org/10.1167/iovs.15-17008

Low Vision

Asymmetry in the Collision Judgments of People With Homonymous Field Defects and Left Hemispatial Neglect Free
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Kevin E. Houston; Russell L. Woods; Robert B. Goldstein; Eli Peli; Gang Luo; Alex R. Bowers
Tags: hemispatial neglect, judgment, neglect
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4135-4142. doi:https://doi.org/10.1167/iovs.14-15492

Multidisciplinary Ophthalmic Imaging

Correlation Between Multimodal Microscopy, Tissue Morphology, and Enzymatic Resistance in Riboflavin-UVA Cross-Linked Human Corneas Free
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Maria Laggner; Andreas Pollreisz; Gerald Schmidinger; Ruth A. Byrne; Clemens Scheinecker; Ursula Schmidt-Erfurth; Ying-Ting Chen
Tags: body tissue, cornea, corneal collagen cross-linking, diagnostic imaging, riboflavin
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3584-3592. doi:https://doi.org/10.1167/iovs.15-16508
Correlation Between Peripapillary Choroidal Thickness and Retinal Vessel Oxygen Saturation in Young Healthy Individuals and Glaucoma Patients Free
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Karel Van Keer; Luís Abegão Pinto; Koen Willekens; Ingeborg Stalmans; Evelien Vandewalle
Tags: glaucoma, oxygen saturation measurement, retinal vessels
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3758-3762. doi:https://doi.org/10.1167/iovs.14-16225
In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT Free
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Leon C. Ho; Bo Wang; Ian P. Conner; Yolandi van der Merwe; Richard A. Bilonick; Seong-Gi Kim; Ed X. Wu; Ian A. Sigal; Gadi Wollstein; Joel S. Schuman; Kevin C. Chan
Tags: biological transport, eye, magnetic resonance imaging, n-methylaspartate, optic nerve
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3788-3800. doi:https://doi.org/10.1167/iovs.14-15552
Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images Free
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Chieh-Li Chen; Hiroshi Ishikawa; Gadi Wollstein; Richard A. Bilonick; Ian A. Sigal; Larry Kagemann; Joel S. Schuman
Tags: eye, optical coherence tomography, retinal nerve fiber layer, image quality, pixel
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3810-3819. doi:https://doi.org/10.1167/iovs.15-16502
Halo and Through-Focus Performance of Four Diffractive Multifocal Intraocular Lenses Free
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Fidel Vega; Francisco Alba-Bueno; María S. Millán; Consuelo Varón; Miguel A. Gil; Jose A. Buil
Tags: image quality, immunoglobulins, thyroid-stimulating, intraocular lens implant device, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3967-3975. doi:https://doi.org/10.1167/iovs.15-16600
Noninvasive Visualization and Analysis of the Human Parafoveal Capillary Network Using Swept Source OCT Optical Microangiography Free
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Laura Kuehlewein; Tudor C. Tepelus; Lin An; Mary K. Durbin; Sowmya Srinivas; Srinivas R. Sadda
Tags: blood capillaries, optics, parafoveal region
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3984-3988. doi:https://doi.org/10.1167/iovs.15-16510

Physiology and Pharmacology

Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine Free
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James Brian McAlvin; Changyou Zhan; Jenny C. Dohlman; Paraskevi E. Kolovou; Borja Salvador-Culla; Daniel S. Kohane
Tags: cornea, dexmedetomidine, sodium channel blockers
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3820-3826. doi:https://doi.org/10.1167/iovs.15-16591
Role of Endothelium in Abnormal Cannabidiol-Induced Vasoactivity in Retinal Arterioles Free
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Er-Ning Su; Melanie E. Kelly; Stephen J. Cringle; Dao-Yi Yu
Tags: arteriole, cannabidiol, endothelin-1, endothelium
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4029-4037. doi:https://doi.org/10.1167/iovs.14-14879

Retina

A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice Free
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Bogale Aredo; Tao Li; Xiao Chen; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Darlene Gou; Biren Zhao; Yuguang He; Rafael L. Ufret-Vincenty
Tags: mice, oxidative stress, inflammation, microglia, retina
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3427-3440. doi:https://doi.org/10.1167/iovs.14-16089
Clinical and Echographic Features of Retinochoroidal and Optic Nerve Colobomas Free
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Vincent D. Venincasa; Yasha S. Modi; Hassan A. Aziz; Bernadette Ayres; Claus Zehetner; Wei Shi; Timothy G. Murray; Harry W. Flynn, Jr; Audina M. Berrocal
Tags: coloboma, retinal detachment, optic nerve
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3615-3620. doi:https://doi.org/10.1167/iovs.15-16596
Real-Time Monitoring of Suprachoroidal Space (SCS) Following SCS Injection Using Ultra-High Resolution Optical Coherence Tomography in Guinea Pig Eyes Free
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Bing Gu; Jinkun Liu; Xiaoli Li; QingKai Ma; Meixiao Shen; Lingyun Cheng
Tags: eye, guinea, normal saline, optical coherence tomography, saline solutions
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3623-3634. doi:https://doi.org/10.1167/iovs.15-16597
Effect of Pupil Size on Flicker ERGs Recorded With RETeval System: New Mydriasis-Free Full-Field ERG System Free
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Kumiko Kato; Mineo Kondo; Masahiko Sugimoto; Kengo Ikesugi; Hisashi Matsubara
Tags: electroretinography, mydriasis, photopsia, pupil size, pupil
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3684-3690. doi:https://doi.org/10.1167/iovs.14-16349
Characterization of Retinal Vascular and Neural Damage in a Novel Model of Diabetic Retinopathy Free
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Lakshini Y. Weerasekera; Lois A. Balmer; Ramesh Ram; Grant Morahan
Tags: diabetes mellitus, diabetic retinopathy, mice, retina, blood capillaries
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3721-3730. doi:https://doi.org/10.1167/iovs.14-16289
In Vivo Study of Retinal Transmission Function in Different Sections of the Choroidal Structure Using Multispectral Imaging Free
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Shanshan Li; Lvzhen Huang; Yujing Bai; Yong Cheng; Jun Tian; Shengfeng Wang; Yaoyao Sun; Kai Wang; Fei Wang; Qi Zhang; Qingyu Meng; Yun Qi; Yang Yu; Xiaoxin Li
Tags: choroid, diagnostic imaging, reliability
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3731-3742. doi:https://doi.org/10.1167/iovs.14-15783
Progression of Vision Loss in Macular Telangiectasia Type 2 Free
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Tjebo F. C. Heeren; Traci Clemons; Hendrik P. N. Scholl; Alan C. Bird; Frank G. Holz; Peter Charbel Issa
Tags: blindness, scotoma, telangiectasis, eye
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3905-3912. doi:https://doi.org/10.1167/iovs.15-16915
Retinal Structure and Function in Perinatally HIV-Infected and cART-Treated Children: A Matched Case–Control Study Free
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Nazli Demirkaya; Sophie Cohen; Ferdinand W. N. M. Wit; Michael D. Abramoff; Reinier O. Schlingemann; Taco W. Kuijpers; Peter Reiss; Dasja Pajkrt; Frank D. Verbraak
Tags: child, hiv, retina, vision
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3945-3954. doi:https://doi.org/10.1167/iovs.15-16855
Ganglion Cell–Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Thicknesses in Age-Related Macular Degeneration Free
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Eun Kyoung Lee; Hyeong Gon Yu
Tags: age-related macular degeneration, drusen, eye, ganglia, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3976-3983. doi:https://doi.org/10.1167/iovs.15-17013
Quantitative Comparison of Retinal Capillary Images Derived By Speckle Variance Optical Coherence Tomography With Histology Free
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Priscilla Ern Zhi Tan; Chandrakumar Balaratnasingam; Jing Xu; Zaid Mammo; Sherry X. Han; Paul Mackenzie; Andrew W. Kirker; David Albiani; Andrew B. Merkur; Marinko V. Sarunic; Dao-Yi Yu
Tags: blood capillaries, heterogeneity of variance, histology, optical coherence tomography
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3989-3996. doi:https://doi.org/10.1167/iovs.14-15879
African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans Free
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Arti Tandon; Ching J. Chen; Alan Penman; Heather Hancock; Maurice James; Deeba Husain; Christopher Andreoli; Xiaohui Li; Jane Z. Kuo; Omolola Idowu; Daniel Riche; Evangelia Papavasilieou; Stacey Brauner; Sataria O. Smith; Suzanne Hoadley; Cole Richardson; Troy Kieser; Vanessa Vazquez; Cheryl Chi; Marlene Fernandez; Maegan Harden; Mary Frances Cotch; David Siscovick; Herman A. Taylor; James G. Wilson; David Reich; Tien Y. Wong; Ronald Klein; Barbara E. K. Klein; Jerome I. Rotter; Nick Patterson; Lucia Sobrin
Tags: african american, chromosome mapping, diabetes mellitus, type 2, proliferative diabetic retinopathy, genome
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3999-4005. doi:https://doi.org/10.1167/iovs.15-16674
Layer-Specific Manganese-Enhanced MRI of the Diabetic Rat Retina in Light and Dark Adaptation at 11.7 Tesla Free
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Eric R. Muir; Saurav B. Chandra; Bryan H. De La Garza; Chakradhar Velagapudi; Hanna E. Abboud; Timothy Q. Duong
Tags: dark adaptation, diabetes mellitus, magnetic resonance imaging, manganese, retina
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4006-4012. doi:https://doi.org/10.1167/iovs.14-16128
The Plane of Vitreoretinal Separation and Results of Vitrectomy Surgery in Patients Given Ocriplasmin for Idiopathic Macular Hole Free
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David H. W. Steel; Maria T. Sandinha; Kathryn White
Tags: macular holes, surgical procedures, operative, vitrectomy, surgery specialty, eye
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4038-4044. doi:https://doi.org/10.1167/iovs.15-16409
Expression of Angiogenic MicroRNAs in Endothelial Progenitor Cells From Type 1 Diabetic Patients With and Without Diabetic Retinopathy Free
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Nuria García de la Torre; Raquel Fernández-Durango; Raquel Gómez; Manuel Fuentes; Manuela Roldán-Pallarés; Juan Donate; Ana Barabash; Bárbara Alonso; Isabelle Runkle; Alejandra Durán; Miguel Angel Rubio; Alfonso L. Calle-Pascual
Tags: angiogenesis, diabetes mellitus, diabetic retinopathy, endothelial progenitor cells, micrornas
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4090-4098. doi:https://doi.org/10.1167/iovs.15-16498
Restoration of Outer Retinal Layers After Aflibercept Therapy in Exudative AMD: Prognostic Value Free
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Florence Coscas; Gabriel Coscas; Marco Lupidi; Ali Dirani; Mayer Srour; Oudy Semoun; Catherine Français; Eric H. Souied
Tags: aflibercept, embryonic lethal mutation, patient prognosis, edema
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4129-4134. doi:https://doi.org/10.1167/iovs.15-16735
Relationship Between Retinal Blood Flow and Serum Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus Free
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Tsuneaki Omae; Taiji Nagaoka; Akitoshi Yoshida
Tags: adiponectin, diabetes mellitus, type 2, vascular flow
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4143-4149. doi:https://doi.org/10.1167/iovs.15-16447

Retinal Cell Biology

Pericyte Chemomechanics and the Angiogenic Switch: Insights Into the Pathogenesis of Proliferative Diabetic Retinopathy? Free
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Jennifer T. Durham; Brian M. Dulmovits; Stephen M. Cronk; Anthony R. Sheets; Ira M. Herman
Tags: diabetes mellitus, pericytes, endothelium, proliferative diabetic retinopathy, pathogenesis
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3441-3459. doi:https://doi.org/10.1167/iovs.14-13945
An N-Terminal ER Export Signal Facilitates the Plasma Membrane Targeting of HCN1 Channels in Photoreceptors Free
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Yuan Pan; Joseph G. Laird; David M. Yamaguchi; Sheila A. Baker
Tags: cell membrane, photoreceptors, leucine, animals, transgenic, proteins
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3514-3521. doi:https://doi.org/10.1167/iovs.15-16902

Visual Neuroscience

The Post-Illumination Pupil Response (PIPR) Free
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Prakash Adhikari; Andrew J. Zele; Beatrix Feigl
Tags: lighting, melanopsin, pupil reaction, pupil
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3838-3849. doi:https://doi.org/10.1167/iovs.14-16233

Visual Psychophysics and Physiological Optics

Age-Related Changes in the Anterior Segment Biometry During Accommodation Free
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Yilei Shao; Aizhu Tao; Hong Jiang; Xinjie Mao; Jianguang Zhong; Meixiao Shen; Fan Lu; Zhe Xu; Carol L. Karp; Jianhua Wang
Tags: biometry, ciliary muscle, lens (device), lens, crystalline, visual accommodation
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3522-3530. doi:https://doi.org/10.1167/iovs.15-16825
Standard Automated Perimetry: Determining Spatial Summation and Its Effect on Contrast Sensitivity Across the Visual Field Free
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Sieu K. Khuu; Michael Kalloniatis
Tags: contrast sensitivity, spatial summation, visual fields, perimetry
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3565-3576. doi:https://doi.org/10.1167/iovs.14-15606

Review

Behavioral Training as New Treatment for Adult Amblyopia: A Meta-Analysis and Systematic Review Free
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Inna Tsirlin; Linda Colpa; Herbert C. Goltz; Agnes M. F. Wong
Tags: adult, amblyopia, training, visual acuity, meta-analysis
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4061-4075. doi:https://doi.org/10.1167/iovs.15-16583

Letters to the Editor

Factors Affecting Interocular Differences in Retinal Nerve Fiber Layer Thickness Free
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Young Hoon Hwang
Tags: retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3621-3622. doi:https://doi.org/10.1167/iovs.15-16541
Paravascular Pathways in the Eye: Is There an ‘Ocular Glymphatic System'? Free
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Alastair K. Denniston; Pearse A. Keane
Tags: eye
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 3955-3956. doi:https://doi.org/10.1167/iovs.15-17243

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science June 2015, Vol.56, 4125-4128. doi:https://doi.org/10.1167/iovs.14-16221a
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