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Editorial

Open Access Coming to IOVS Free
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Thomas Yorio
Tags: chief complaint, community, fees and charges, internet, journal impact factor
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5315. doi:https://doi.org/10.1167/iovs.15-17823

Research Highlight

Corneal Confocal Microscopy and Diabetic Neuropathy Free
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Sanjay V. Patel
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5066. doi:https://doi.org/10.1167/iovs.15-17682
Amblyopia Reveals the Neuroanatomical Consequences of Prolonged Abnormal Binocular Experience Free
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Bas Rokers
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5161. doi:https://doi.org/10.1167/iovs.15-17626
Enhancing Inflammation as an Adjuvant to Neovascular AMD Therapy Free
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Andrew D. Dick
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5431. doi:https://doi.org/10.1167/iovs.15-17613

Anatomy and Pathology/Oncology

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines Free
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Nasrin Refaian; Simona L. Schlereth; Konrad R. Koch; Maria Notara; Deniz Hos; Melina Mescher; Sandra Iden; Jacobus J. Bosch; Martine J. Jager; Claus Cursiefen; Ludwig M. Heindl
Tags: cell lines, uveal melanoma, conjunctiva, eye melanomas, rna, messenger
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5691-5697. doi:https://doi.org/10.1167/iovs.15-16829

Biochemistry and Molecular Biology

Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics Free
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Kapil Gadkar; Cinthia V. Pastuskovas; Jennifer E. Le Couter; J. Michael Elliott; Jianhuan Zhang; Chingwei V. Lee; Sarah Sanowar; Germaine Fuh; Hok Seon Kim; T. Noelle Lombana; Christoph Spiess; Makia Nakamura; Phil Hass; Whitney Shatz; Y. Gloria Meng; Justin M. Scheer
Tags: antibodies, disulfides, gadolinium, molecule, therapeutics
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5390-5400. doi:https://doi.org/10.1167/iovs.15-17108
Visual Cone Arrestin 4 Contributes to Visual Function and Cone Health Free
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Janise D. Deming; Joseph S. Pak; Bruce M. Brown; Moon K. Kim; Moe H. Aung; Yun Sung Eom; Jung-a Shin; Eun-Jin Lee; Machelle T. Pardue; Cheryl Mae Craft
Tags: arrestin, mice, opsin, retinal cone, vision
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5407-5416. doi:https://doi.org/10.1167/iovs.15-16647
IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates Free
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Sarah L. Doyle; Francisco J. López; Lucia Celkova; Kiva Brennan; Kelly Mulfaul; Ema Ozaki; Paul F. Kenna; Edit Kurali; Natalie Hudson; Teresa Doggett; Thomas A. Ferguson; Peter Humphries; Peter Adamson; Matthew Campbell
Tags: exudative age-related macular degeneration, immunotherapy, interleukin-18, primates
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5424-5430. doi:https://doi.org/10.1167/iovs.15-17264
Platelet-Derived Growth Factor-BB Enhances Adipogenesis in Orbital Fibroblasts Free
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Sita Virakul; Virgil A. S. H. Dalm; Dion Paridaens; Willem A. van den Bosch; Monique T. Mulder; Nattiya Hirankarn; P. Martin van Hagen; Willem A. Dik
Tags: fibroblasts, platelet-derived growth factor, dasatinib, peroxisome proliferator-activated receptors, rna, messenger
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5457-5464. doi:https://doi.org/10.1167/iovs.15-17001

Clinical and Epidemiologic Research

Analysis of Changes in Refraction and Biometry of Atropine- and Placebo-Treated Eyes Free
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Arjunan Kumaran; Hla M. Htoon; Donald Tan; Audrey Chia
Tags: atropine, biometry, eye, placebos, refraction
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5650-5655. doi:https://doi.org/10.1167/iovs.14-14716
Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment Free
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Mengxi Yu; Zhifeng Wu; Zhengwei Zhang; Xiaoli Huang; Qing Zhang
Tags: choroidal detachment, metabolites, metabolomics, radiation recall dermatitis, rhegmatogenous retinal detachment
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5706-5713. doi:https://doi.org/10.1167/iovs.14-16338

Cornea

In Vivo Confocal Microscopy of Corneal Nerves: An Ocular Biomarker for Peripheral and Cardiac Autonomic Neuropathy in Type 1 Diabetes Mellitus Free
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Stuti L. Misra; Jennifer P. Craig; Dipika V. Patel; Charles N. J. McGhee; Monika Pradhan; Kevin Ellyett; Dean Kilfoyle; Geoffrey D. Braatvedt
Tags: biological markers, cornea, diabetes mellitus, diabetes mellitus, type 1, diabetic autonomic neuropathy
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5060-5065. doi:https://doi.org/10.1167/iovs.15-16711
Focused Tortuosity Definitions Based on Expert Clinical Assessment of Corneal Subbasal Nerves Free
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Neil Lagali; Enea Poletti; Dipika V. Patel; Charles N. J. McGhee; Pedram Hamrah; Ahmad Kheirkhah; Mitra Tavakoli; Ioannis N. Petropoulos; Rayaz A. Malik; Tor Paaske Utheim; Andrey Zhivov; Oliver Stachs; Karen Falke; Sabine Peschel; Rudolf Guthoff; Cecilia Chao; Blanka Golebiowski; Fiona Stapleton; Alfredo Ruggeri
Tags: consensus, cornea, neurons
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5102-5109. doi:https://doi.org/10.1167/iovs.15-17284
Topical TSG-6 Administration Protects the Ocular Surface in Two Mouse Models of Inflammation-Related Dry Eye Free
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Min Joung Lee; Dong Hyun Kim; Jin Suk Ryu; Ah Young Ko; Jung Hwa Ko; Mee Kum Kim; Won Ryang Wee; Sang In Khwarg; Joo Youn Oh
Tags: dry eye syndromes, inflammation, mice, cornea, eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5175-5181. doi:https://doi.org/10.1167/iovs.14-16307
Roles of Epithelial Cell–Derived Type 2–Initiating Cytokines in Experimental Allergic Conjunctivitis Free
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Yosuke Asada; Susumu Nakae; Waka Ishida; Kanji Hori; Jobu Sugita; Katsuko Sudo; Ken Fukuda; Atsuki Fukushima; Hajime Suto; Akira Murakami; Hirohisa Saito; Nobuyuki Ebihara; Akira Matsuda
Tags: allergic conjunctivitis, body tissue, conjunctiva, cytokine, epithelial cells
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5194-5202. doi:https://doi.org/10.1167/iovs.15-16563
Role of Matrix Metalloproteinases 2 and 9 in Lacrimal Gland Disease in Animal Models of Sjögren's Syndrome Free
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Hema S. Aluri; Claire L. Kublin; Suharika Thotakura; Helene Armaos; Mahta Samizadeh; Dillon Hawley; William M. Thomas; Paul Leavis; Helen P. Makarenkova; Driss Zoukhri
Tags: gelatinase a, lacrimal gland, sjogren's syndrome, matrix metalloproteinases, peptides
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5218-5228. doi:https://doi.org/10.1167/iovs.15-17003
Evidence for the Involvement of MMP14 in MMP2 Processing and Recruitment in Exosomes of Corneal Fibroblasts Free
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Kyu-Yeon Han; Jennifer Dugas-Ford; Motoharu Seiki; Jin-Hong Chang; Dimitri T. Azar
Tags: cornea, exosomes, fibroblasts, gelatinase a, biological transport
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5323-5329. doi:https://doi.org/10.1167/iovs.14-14417
Imaging of the Corneal Subbasal Whorl-like Nerve Plexus: More Accurate Depiction of the Extent of Corneal Nerve Damage in Patients With Diabetes Free
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Tsugiaki Utsunomiya; Taiji Nagaoka; Kazuomi Hanada; Tsuneaki Omae; Harumasa Yokota; Atsuko Abiko; Masakazu Haneda; Akitoshi Yoshida
Tags: cornea, diabetes mellitus, diabetes mellitus, type 2, diagnostic imaging, nerve injuries
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5417-5423. doi:https://doi.org/10.1167/iovs.15-16609
MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect Free
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Kyu-Yeon Han; Jennifer Dugas-Ford; Hyun Lee; Jin-Hong Chang; Dimitri T. Azar
Tags: angiogenesis inhibitors, cornea, cytokinesis, vascular endothelial growth factor a, cd40 ligand
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5450-5456. doi:https://doi.org/10.1167/iovs.14-16248
Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells Free
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Xia Hua; Ruzhi Deng; Jin Li; Wei Chi; Zhitao Su; Jing Lin; Stephen C. Pflugfelder; De-Quan Li
Tags: levocarnitine, wounds and injuries, corneal epithelial cells
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5503-5511. doi:https://doi.org/10.1167/iovs.14-16247
Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness Free
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Demelza R. Koehn; Kacie J. Meyer; Michael G. Anderson
Tags: cornea, epithelium, genes, genetics, mice
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5599-5607. doi:https://doi.org/10.1167/iovs.15-17179
The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment Free
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Jin Hyoung Park; Soon-Suk Kang; Jae Yong Kim; Hungwon Tchah
Tags: acetylcysteine, antioxidants, glucose, conjunctival epithelial cells, conjunctiva
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5614-5621. doi:https://doi.org/10.1167/iovs.15-16909
Second Harmonic Generation Imaging Analysis of Collagen Arrangement in Human Cornea Free
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Choul Yong Park; Jimmy K. Lee; Roy S. Chuck
Tags: collagen, cornea, diagnostic imaging, harmonics
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5622-5629. doi:https://doi.org/10.1167/iovs.15-17129
The Reliability and Reproducibility of Corneal Confocal Microscopy in Children Free
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Danièle Pacaud; Kenneth G. Romanchuk; Mitra Tavakoli; Claire Gougeon; Heidi Virtanen; Maryam Ferdousi; Alberto Nettel-Aguirre; Jean K. Mah; Rayaz A. Malik
Tags: child, cornea, microscopy, confocal, reliability, diabetic neuropathies
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5636-5640. doi:https://doi.org/10.1167/iovs.15-16995

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Visual Processing in Infantile Nystagmus Is Not Slow Free
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Matt J. Dunn; Tom H. Margrain; J. Margaret Woodhouse; Jonathan T. Erichsen
Tags: pathologic nystagmus, visual processing, reaction time, saccades
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5094-5101. doi:https://doi.org/10.1167/iovs.15-16977
Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011 Free
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Ren Jie; Liang Xu; Ya Xing Wang; Li Zhang; Qi Sheng You; Hua Yang; Jost B. Jonas
Tags: diabetic retinopathy, eye, hypertension, incidence, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5118-5124. doi:https://doi.org/10.1167/iovs.15-16682
The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia Free
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Yiran Duan; Anthony M. Norcia; Jason D. Yeatman; Aviv Mezer
Tags: optic radiation, strabismic amblyopia, white matter, amblyopia
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5152-5160. doi:https://doi.org/10.1167/iovs.15-17097
Mechanisms of Vertical Fusional Vergence in Patients With “Congenital Superior Oblique Paresis” Investigated With an Eye-Tracking Haploscope Free
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Kristina Irsch; David L. Guyton; Hee-Jung S. Park; Howard S. Ying
Tags: eye, eye movement, eye-tracking, paresis, standard operating procedure
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5362-5369. doi:https://doi.org/10.1167/iovs.15-16604
Convergence and Accommodation Development Is Preprogrammed in Premature Infants Free
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Anna M. Horwood; Sonia S. Toor; Patricia M. Riddell
Tags: infant, infant, premature, visual accommodation
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5370-5380. doi:https://doi.org/10.1167/iovs.14-15358
Perceptual Visual Distortions in Adult Amblyopia and Their Relationship to Clinical Features Free
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Marianne E. F. Piano; Peter J. Bex; Anita J. Simmers
Tags: amblyopia, adult
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5533-5542. doi:https://doi.org/10.1167/iovs.15-17071

Genetics

Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma Free
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Puya Gharahkhani; Kathryn P. Burdon; Alex W. Hewitt; Matthew H. Law; Emmanuelle Souzeau; Grant W. Montgomery; Graham Radford-Smith; David A. Mackey; Jamie E. Craig; Stuart MacGregor
Tags: myoc gene, open-angle glaucoma, screening, genotype determination, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5087-5093. doi:https://doi.org/10.1167/iovs.15-17305
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy Free
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Soo Hyun Seo; Young Suk Yu; Sung Wook Park; Jeong Hun Kim; Hyun Kyung Kim; Sung Im Cho; Hyunwoong Park; Seung Jun Lee; Moon-Woo Seong; Sung Sup Park; Ji Yeon Kim
Tags: familial exudative vitreoretinopathies, mutation, genes
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5143-5151. doi:https://doi.org/10.1167/iovs.14-15680
Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats Free
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Ron Ofri; Christopher M. Reilly; David J. Maggs; Paul G. Fitzgerald; Yael Shilo-Benjamini; Kathryn L. Good; Robert A. Grahn; Danielle D. Splawski; Leslie A. Lyons
Tags: adaptive testing, autosomal recessive inheritance, cats, retinal degeneration, electroretinography
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5299-5308. doi:https://doi.org/10.1167/iovs.15-16585
Genomic Copy Number Variations of the Complement Component C4B Gene Are Associated With Chronic Central Serous Chorioretinopathy Free
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Myrte B. Breukink; Rosa L. Schellevis; Camiel J. F. Boon; Sascha Fauser; Carel B. Hoyng; Anneke I. den Hollander; Eiko K. de Jong
Tags: central serous chorioretinopathy, complement system proteins, copy number polymorphism, genes, genome
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5608-5613. doi:https://doi.org/10.1167/iovs.15-17343

Glaucoma

The Relationship Between Helicobacter pylori Infection and Open-Angle Glaucoma: A Meta-Analysis Free
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Jun Zeng; Hanhan Liu; Xiao Liu; Chun Ding
Tags: helicobacter infections, helicobacter pylori, infections, meta-analysis, open-angle glaucoma
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5238-5245. doi:https://doi.org/10.1167/iovs.15-17059
Relationship Between Nocturnal Intraocular Pressure Elevation and Diurnal Intraocular Pressure Level in Normal-Tension Glaucoma Patients Free
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Yeji Moon; Jin Young Lee; Da Woon Jeong; Soa Kim; Seungbong Han; Michael S. Kook
Tags: intraocular pressure, night time, low tension glaucoma
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5271-5279. doi:https://doi.org/10.1167/iovs.15-17062
Multivariate Model of the Intersubject Variability of the Retinal Nerve Fiber Layer Thickness in Healthy Subjects Free
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Ivania Pereira; Hemma Resch; Florian Schwarzhans; Jing Wu; Stephan Holzer; Barbara Kiss; Florian Frommlet; Georg Fischer; Clemens Vass
Tags: retinal nerve fiber layer
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5290-5298. doi:https://doi.org/10.1167/iovs.15-17346
Evaluation of Chitosan/Aptamer Targeting TGF-β Receptor II Thermo-Sensitive Gel for Scarring in Rat Glaucoma Filtration Surgery Free
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Xiaoyan Zhu; Duo Xu; Xiaomin Zhu; Lei Li; Haijun Li; Feng Guo; Xia Chen; Yan Tan; Lin Xie
Tags: blister, chitosan, cicatrix, conjunctiva, eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5465-5476. doi:https://doi.org/10.1167/iovs.15-16683
Comparison of Longitudinal Changes in Functional and Structural Measures for Evaluating Progression of Glaucomatous Optic Neuropathy Free
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Kenji Suda; Masanori Hangai; Tadamichi Akagi; Hisashi Noma; Yugo Kimura; Tomoko Hasegawa; Hiroshi Yamada; Munemitsu Yoshikawa; Hideo Nakanishi; Hanako Ohashi Ikeda; Nagahisa Yoshimura
Tags: glaucoma, optic nerve disorders, eye, diagnostic imaging
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5477-5484. doi:https://doi.org/10.1167/iovs.15-16704
Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling Free
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Colleen M. McDowell; Humberto Hernandez; Weiming Mao; Abbot F. Clark
Tags: eye, mice, ocular hypertension, signal transduction, smad3 gene
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5485-5492. doi:https://doi.org/10.1167/iovs.15-16993
Evaluation of the Structure–Function Relationship in Glaucoma Using a Novel Method for Estimating the Number of Retinal Ganglion Cells in the Human Retina Free
PDF
Ali S. Raza; Donald C. Hood
Tags: glaucoma, retina, retinal ganglion cells, eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5548-5556. doi:https://doi.org/10.1167/iovs.14-16366
Corneal Deformation Response in Patients With Primary Open-Angle Glaucoma and in Healthy Subjects Analyzed by Corvis ST Free
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Wei Wang; Shaolin Du; Xiulan Zhang
Tags: biomechanics, cornea, open-angle glaucoma, meta-analysis
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5557-5565. doi:https://doi.org/10.1167/iovs.15-16926
The Relationship Between Visual Acuity and the Reproducibility of Visual Field Measurements in Glaucoma Patients Free
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Masato Matsuura; Kazunori Hirasawa; Hiroshi Murata; Ryo Asaoka
Tags: glaucoma, visual acuity, visual fields
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5630-5635. doi:https://doi.org/10.1167/iovs.15-17576
Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells Free
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Padmanabhan Paranji Pattabiraman; Ponugoti Vasantha Rao
Tags: actins, cytoskeleton, myoc gene, proteins, trabecular meshwork
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5656-5669. doi:https://doi.org/10.1167/iovs.15-17204
Diagnosis of Early-Stage Glaucoma by Grid-Wise Macular Inner Retinal Layer Thickness Measurement and Effect of Compensation of Disc-Fovea Inclination Free
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Chihiro Mayama; Hitomi Saito; Hiroyo Hirasawa; Atsuo Tomidokoro; Makoto Araie; Aiko Iwase; Shinji Ohkubo; Kazuhisa Sugiyama; Masanori Hangai; Nagahisa Yoshimura
Tags: fovea centralis, glaucoma, specificity of diagnostic test, eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5681-5690. doi:https://doi.org/10.1167/iovs.15-17208
Does Myopia Affect Angle Closure Prevalence Free
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Guangming Jin; Xiaohu Ding; Xinxing Guo; Billy Heung Wing Chang; Capucine Odouard; Mingguang He
Tags: myopia, prevalence
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5714-5719. doi:https://doi.org/10.1167/iovs.15-16914

Immunology and Microbiology

Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype Free
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Mary J. Mattapallil; Phyllis B. Silver; Lizette M. Cortes; Anthony J. St. Leger; Yingyos Jittayasothorn; Jennifer L. Kielczewski; James J. Moon; Chi-Chao Chan; Rachel R. Caspi
Tags: epitopes, mice, peptides, haplotypes, immunization
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5439-5449. doi:https://doi.org/10.1167/iovs.15-17280

Lens

Astigmatism of the Ex Vivo Human Lens: Surface and Gradient Refractive Index Age-Dependent Contributions Free
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Judith Birkenfeld; Alberto de Castro; Susana Marcos
Tags: astigmatism, lens (device), lens, crystalline, refractive index
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5067-5073. doi:https://doi.org/10.1167/iovs.15-16484
Identification and Functional Characterization of a GSH Conjugate Efflux Pathway in the Rat Lens Free
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Ankita Umapathy; Bo Li; Paul James Donaldson; Julie Ching-Hsia Lim
Tags: lens (device), lens, crystalline, membrane transport proteins
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5256-5268. doi:https://doi.org/10.1167/iovs.15-17109
Lens Position and Age: The Central India Eye and Medical Study Free
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Jost B. Jonas; Rafael Iribarren; Vinay Nangia; Ajit Sinha; Priyanka Pardhi; Ritesh Shukla; Songhomitra Panda-Jonas
Tags: eye, india, lens (device), lens, crystalline, anterior chamber of eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5309-5314. doi:https://doi.org/10.1167/iovs.15-16796
Measurement of Ex Vivo Porcine Lens Shape During Simulated Accommodation, Before and After fs-Laser Treatment Free
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Jan Hahn; Michael Fromm; Fedaa AL Halabi; Silke Besdo; Holger Lubatschowski; Tammo Ripken; Alexander Krüger
Tags: lens (device), lens, crystalline, visual accommodation, suidae, shape
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5332-5343. doi:https://doi.org/10.1167/iovs.14-16185
Assessment of Lens Center Using Optical Coherence Tomography, Magnetic Resonance Imaging, and Photographs of the Anterior Segment of the Eye Free
PDF
Yong Eun Lee; Choun-Ki Joo
Tags: eye, lens, crystalline, magnetic resonance imaging, optical coherence tomography, postoperative care
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5512-5518. doi:https://doi.org/10.1167/iovs.15-17454
Molecular Inflammation in the Contralateral Eye After Cataract Surgery in the First Eye Free
PDF
Xiang-Jia Zhu; Don Wolff; Ke-Ke Zhang; Wen-Wen He; Xing-Huai Sun; Yi Lu; Peng Zhou
Tags: antibodies, cataract surgery, cytokine, eye, inflammation
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5566-5573. doi:https://doi.org/10.1167/iovs.15-16531

Nantotechnology and Regenerative Medicine

Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model Free
PDF
Ko Eun Kim; Inseok Jang; Hyungwon Moon; Yu Jeong Kim; Jin Wook Jeoung; Ki Ho Park; Hyuncheol Kim
Tags: albumins, brimonidine, nanoparticles, neuroprotective effect, optic nerve
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5641-5649. doi:https://doi.org/10.1167/iovs.15-16538

Physiology and Pharmacology

CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signaling in Rat Retinal Arterioles Free
PDF
José A. Fernández; Mary K. McGahon; J. Graham McGeown; Tim M. Curtis
Tags: arteriole, signal transduction
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5125-5132. doi:https://doi.org/10.1167/iovs.15-17299
VEGF Receptor-2–Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress Free
PDF
Travis W. Hein; Robert H. Rosa, Jr; Yi Ren; Wenjuan Xu; Lih Kuo
Tags: 1-phosphatidylinositol 3-kinase, arteriole, calpain, dilatation, pathologic, endothelium
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5381-5389. doi:https://doi.org/10.1167/iovs15-16950

Retina

Baseline Predictors for Good Versus Poor Visual Outcomes in the Treatment of Neovascular Age-Related Macular Degeneration With Intravitreal Anti-VEGF Therapy Free
PDF
Bora Chae; Jesse J. Jung; Sarah Mrejen; Roberto Gallego-Pinazo; Nicolas A. Yannuzzi; Samir N. Patel; Christine Y. Chen; Marcela Marsiglia; Sucharita Boddu; K. Bailey Freund
Tags: anti-vascular endothelial growth factor therapy, exudative age-related macular degeneration, vascular endothelial growth factor a, visual acuity, eye
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5040-5047. doi:https://doi.org/10.1167/iovs.15-16494
Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography Free
PDF
Zaid Mammo; Chandrakumar Balaratnasingam; Paula Yu; Jing Xu; Morgan Heisler; Paul Mackenzie; Andrew Merkur; Andrew Kirker; David Albiani; K. Bailey Freund; Marinko V. Sarunic; Dao-Yi Yu
Tags: angiogram, blood capillaries, eye, fovea centralis, heterogeneity of variance
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5074-5086. doi:https://doi.org/10.1167/iovs.15-16773
Visual Impairments Following Term Neonatal Encephalopathy: Do Retinal Impairments Also Play a Role? Free
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Suna Jung; Anna Polosa; Pierre Lachapelle; Pia Wintermark
Tags: hypoxia, ischemia, neonatal encephalopathy, newborn, retina
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5182-5193. doi:https://doi.org/10.1167/iovs.15-16407
OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy Free
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Michel M. Teussink; Myrte B. Breukink; Mark J. J. P. van Grinsven; Carel B. Hoyng; B. Jeroen Klevering; Camiel J. F. Boon; Eiko K. de Jong; Thomas Theelen
Tags: angiogram, central serous chorioretinopathy, fluorescein, indocyanine green angiography
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5229-5237. doi:https://doi.org/10.1167/iovs.15-17140
Polarization-Sensitive Optical Coherence Tomography and Conventional Retinal Imaging Strategies in Assessing Foveal Integrity in Geographic Atrophy Free
PDF
Ramzi G. Sayegh; Stefan Zotter; Philip K. Roberts; Maciej M. Kandula; Stefan Sacu; David P. Kreil; Bernhard Baumann; Michael Pircher; Christoph K. Hitzenberger; Ursula Schmidt-Erfurth
Tags: atrophy, diagnostic imaging, optical coherence tomography, retinal imaging, personal integrity
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5246-5255. doi:https://doi.org/10.1167/iovs.14-15114
The Role of LOX and LOXL2 in the Pathogenesis of an Experimental Model of Choroidal Neovascularization Free
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Tine Van Bergen; Rhyannon Spangler; Derek Marshall; Karolien Hollanders; Sara Van de Veire; Evelien Vandewalle; Lieve Moons; Jean Herman; Victoria Smith; Ingeborg Stalmans
Tags: choroidal neovascularization, lasers, pathogenesis, eye, mice
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5280-5289. doi:https://doi.org/10.1167/iovs.14-15513
The Contribution of Genetic Architecture to the 10-Year Incidence of Age-Related Macular Degeneration in the Fellow Eye Free
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Masahiro Miyake; Kenji Yamashiro; Hiroshi Tamura; Kyoko Kumagai; Masaaki Saito; Masako Sugahara-Kuroda; Munemitsu Yoshikawa; Maho Oishi; Yumiko Akagi-Kurashige; Isao Nakata; Hideo Nakanishi; Norimoto Gotoh; Akio Oishi; Fumihiko Matsuda; Ryo Yamada; Chiea-Chuen Khor; Yasuo Kurimoto; Tetsuju Sekiryu; Akitaka Tsujikawa; Nagahisa Yoshimura
Tags: age-related macular degeneration, eye, genes, genetics, incidence
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5353-5361. doi:https://doi.org/10.1167/iovs.14-16020
Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study Free
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Katsumasa Itakura; Ikuno Takahashi; Eiji Nakashima; Masahide Yanagi; Ryo Kawasaki; Kazuo Neriishi; Jie Jin Wang; Tien Yin Wong; Ayumi Hida; Waka Ohishi; Yoshiaki Kiuchi
Tags: age-related macular degeneration, bombs, older adult, prevalence, radiation
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5401-5406. doi:https://doi.org/10.1167/iovs.15-16680
Optical Density of Subretinal Fluid in Retinal Detachment Free
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Ari Leshno; Adiel Barak; Anat Loewenstein; Amit Weinberg; Meira Neudorfer
Tags: optics, radiation recall dermatitis, retinal detachment, vitreous body, postoperative care
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5432-5438. doi:https://doi.org/10.1167/iovs.15-16952
Extent of Detached Retina and Lens Status Influence Intravitreal Protein Expression in Rhegmatogenous Retinal Detachment Free
PDF
Andreas Pollreisz; Stefan Sacu; Katharina Eibenberger; Marion Funk; Danijel Kivaranovic; Gerhard J. Zlabinger; Michael Georgopoulos; Ursula Schmidt-Erfurth
Tags: chemokines, cytokine, eye, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5493-5502. doi:https://doi.org/10.1167/iovs.15-17068
Intraocular Pharmacokinetics of Aflibercept and Vascular Endothelial Growth Factor-A Free
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Nil Celik; Alexander Scheuerle; Gerd U. Auffarth; Jürgen Kopitz; Stefan Dithmar
Tags: aflibercept, pharmacokinetics, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5574-5578. doi:https://doi.org/10.1167/iovs.15-16418
Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration Free
PDF
Rui Zhang; Li-Yuan Wang; Ya-Feng Wang; Chang-Rui Wu; Chun-Ling Lei; Ming-Xu Wang; Le Ma
Tags: age-related macular degeneration, polymorphism, single nucleotide polymorphism, meta-analysis, disease susceptibility
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5590-5598. doi:https://doi.org/10.1167/iovs.15-16830
Characterization of Retinal Disease Progression in a 1-Year Longitudinal Study of Eyes With Mild Nonproliferative Retinopathy in Diabetes Type 2 Free
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Luisa Ribeiro; Francesco Bandello; Amparo Navea Tejerina; Stela Vujosevic; Monica Varano; Catherine Egan; Sobha Sivaprasad; Geeta Menon; Pascale Massin; Frank D. Verbraak; Henrik Lund-Andersen; Jose P. Martinez; Ignasi Jürgens; Erica Smets; Caroline Coriat; Peter Wiedemann; Victor Ágoas; Giuseppe Querques; Frank G. Holz; Sandrina Nunes; Catarina Neves; José Cunha-Vaz; for the EVICR.net Study Group
Tags: diabetes mellitus, type 2, diabetic retinopathy, eye, nonproliferative diabetic retinopathy, retinal diseases
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5698-5705. doi:https://doi.org/10.1167/iovs.15-16708

Retinal Cell Biology

4-Acetoxyphenol Prevents RPE Oxidative Stress–Induced Necrosis by Functioning as an NRF2 Stabilizer Free
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Jakub Hanus; Alexander Kolkin; Julia Chimienti; Sara Botsay; Shusheng Wang
Tags: necrosis, oxidative stress, retinal pigment cell, stabilizer ingredient, stress
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5048-5059. doi:https://doi.org/10.1167/iovs.15-16401
Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy Free
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Manish Mishra; Renu A. Kowluru
Tags: diabetic retinopathy, dna, mitochondrial, methylation, endothelial cells, dna
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5133-5142. doi:https://doi.org/10.1167/iovs.15-16937
Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus–Infected Retinal Pigment Epithelial Cells Free
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Ga Bin Park; Daejin Kim; Yeong Seok Kim; Jin Woo Kim; Hook Sun; Kug-Hwan Roh; Jae Wook Yang; Dae Young Hur
Tags: cytokine, epithelial to mesenchymal transition, herpesvirus 4, human, retina, retinal pigment cell
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5162-5173. doi:https://doi.org/10.1167/iovs.14-16058
Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies Free
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Shanshan Li; Lvzhen Huang; Yaoyao Sun; Yujing Bai; Fei Yang; Wenzhen Yu; Fangting Li; Qi Zhang; Bin Wang; Jian-Guo Geng; Xiaoxin Li
Tags: angiogenesis, choroidal neovascularization, lasers, mice, protein overexpression
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5210-5217. doi:https://doi.org/10.1167/iovs-14-16184
Alteration of N-Glycan Profiles in Diabetic Retinopathy Free
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Saori Inafuku; Kousuke Noda; Maho Amano; Tetsu Ohashi; Chikako Yoshizawa; Wataru Saito; Miyuki Murata; Atsuhiro Kanda; Shin-Ichiro Nishimura; Susumu Ishida
Tags: polysaccharides, vitreous body, diabetic retinopathy
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5316-5322. doi:https://doi.org/10.1167/iovs.15-16747
CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet Free
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Devang L. Bhoiwala; Ying Song; Alyssa Cwanger; Esther Clark; Liang-liang Zhao; Chenguang Wang; Yafeng Li; Delu Song; Joshua L. Dunaief
Tags: iron, mice, diet, retina, iron overload
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5344-5352. doi:https://doi.org/10.1167/iovs.15-17026
Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy Free
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Shikun He; Ernesto Barron; Keijiro Ishikawa; Hossein Nazari Khanamiri; Chris Spee; Peng Zhou; Satoru Kase; Zhuoshi Wang; Laurie Diane Dustin; David R. Hinton
Tags: cell transdifferentiation, deoxycytidine, dna methylation, proteins, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5579-5589. doi:https://doi.org/10.1167/iovs.14-16258

Review

Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries Free
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Gabriel Sosne; Hynda K. Kleinman
Tags: body tissue, cornea, dry eye syndromes, laminin, thymosin
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5110-5117. doi:https://doi.org/10.1167/iovs.15-16890

New Developments in Vision Research

Histopathological Evaluation of a Hydrophobic Terpolymer (PTFE-PVD-PP) as an Implant Material for Nonpenetrating Very Deep Sclerectomy Free
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Rafal Leszczynski; Teresa Gumula; Ewa Stodolak-Zych; Krzysztof Pawlicki; Jaroslaw Wieczorek; Maciej Kajor; Stanislaw Blazewicz
Tags: eye, hydrophobicity, implants, polytetrafluoroethylene, surgical procedures, operative
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5203-5209. doi:https://doi.org/10.1167/iovs.14-16027
Reactivation of the PI3K/Akt Signaling Pathway by the Bisperoxovanadium Compound bpV(pic) Attenuates Photoreceptor Apoptosis in Experimental Retinal Detachment Free
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Dan Mao; Xiaodong Sun
Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, apoptosis, bovine papillomavirus, phosphoinositide 3-kinase
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5519-5532. doi:https://doi.org/10.1167/iovs.15-16757
Tolerance and Relative Utility: Two Proposed Indices for Comparing Change in Clinical Measurement Noise Between Different Populations (Repeatability) or Measurement Methods (Agreement) Free
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Ciara Bergin; Ivo Guber; Kattayoon Hashemi; François Majo
Tags: cohort studies, eye, noise, optical pachymetry, pathology
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5543-5547. doi:https://doi.org/10.1167/iovs.14-16091

Letters to the Editor

Total Corneal Astigmatism Measurement Free
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Virgilio Galvis; Alejandro Tello; Camilo A. Niño; Maria Margarita Parra
Tags: astigmatism, cornea
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5269-5270. doi:https://doi.org/10.1167/iovs.15-16931
Small Fiber Neuropathy and Wilson Disease Free
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Francisco de Assis Aquino Gondim; Joana Gurgel Holanda Filha
Tags: hepatolenticular degeneration, neuropathy, small-fiber
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5330. doi:https://doi.org/10.1167/iovs.15-17241
Author Response: Small Fiber Neuropathy and Wilson Disease Free
PDF
Edoardo Midena
Tags: hepatolenticular degeneration, neuropathy, small-fiber
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5331. doi:https://doi.org/10.1167/iovs.15-17504

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science August 2015, Vol.56, 5174. doi:https://doi.org/10.1167/iovs.15-17702
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