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Research Highlight

The Long-Term Effects on the Retina Damaged by Optic Nerve Axotomy Free
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Robert W. Nickells
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6113. doi:https://doi.org/10.1167/iovs.15-17997

Anatomy and Pathology/Oncology

Mesenchymal Stem Cell–Like Properties of Orbital Fibroblasts in Graves' Orbitopathy Free
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Katarzyna Kozdon; Caroline Fitchett; Geoffrey E. Rose; Daniel G. Ezra; Maryse Bailly
Tags: fibroblasts, mesenchymal stem cells
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5743-5750. doi:https://doi.org/10.1167/iovs.15-16580
Transvitreal Retinochoroidal Biopsy Provides a Representative Sample From Choroidal Melanoma for Detection of Chromosome 3 Aberrations Free
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Mette Bagger; Morten T. Andersen; Steffen Heegaard; Mette K. Andersen; Jens F. Kiilgaard
Tags: biopsy, chromosomes, human, pair 3, neoplasms, malignant melanoma of choroid
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5917-5924. doi:https://doi.org/10.1167/iovs.15-17349
Radiation Treatment Affects Chromosome Testing in Uveal Melanoma Free
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Mehmet Dogrusöz; Wilma G. M. Kroes; Sjoerd G. van Duinen; Carien L. Creutzberg; Mieke Versluis; Jaco C. Bleeker; Marina Marinkovic; Gregorius P. M. Luyten; Martine J. Jager
Tags: chromosomes, karyotype determination procedure, neoplasms, radiation, uveal melanoma
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5956-5964. doi:https://doi.org/10.1167/iovs.15-17092
A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice Free
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Simona L. Schlereth; Sandra Iden; Melina Mescher; Bruce R. Ksander; Jacobus J. Bosch; Claus Cursiefen; Ludwig M. Heindl
Tags: cyclin-dependent kinase 4, malignant melanoma of conjunctiva, melanoma, mice, neoplasms
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5965-5973. doi:https://doi.org/10.1167/iovs.15-17290
In Vivo Detection of Choroidal Abnormalities Related to NF1: Feasibility and Comparison With Standard NIH Diagnostic Criteria in Pediatric Patients Free
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Raffaele Parrozzani; Maurizio Clementi; Luisa Frizziero; Giacomo Miglionico; Pierdavide Perrini; Fabiano Cavarzeran; Olympia Kotsafti; Francesco Comacchio; Eva Trevisson; Enrica Convento; Stefano Fusetti; Edoardo Midena
Tags: lisch nodules, neurofibromatoses, neurofibromatosis 1, pediatrics, united states national institutes of health
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6036-6042. doi:https://doi.org/10.1167/iovs.14-16053

Biochemistry and Molecular Biology

Receptor Protein Tyrosine Phosphatase Sigma (RPTP-σ) Increases pro-MMP Activity in a Trabecular Meshwork Cell Line Following Oxidative Stress Conditions Free
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Michal Zaiden; Elie Beit-Yannai
Tags: cell lines, oxidative stress, phosphoric monoester hydrolases, protein tyrosine phosphatase, proteins
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5720-5730. doi:https://doi.org/10.1167/iovs.14-15975

Cornea

Pharmacokinetics of Meropenem for Use in Bacterial Keratitis Free
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Henri Sueke; Stephen Kaye; Mark C. Wilkinson; Stephnie Kennedy; Victoria Kearns; Yalin Zheng; Paul Roberts; Stephen Tuft; Timothy Neal
Tags: bacterial keratitis, meropenem, cornea, pharmacokinetics, anterior chamber of eye
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5731-5738. doi:https://doi.org/10.1167/iovs.15-17077
Comparison of Standard Versus Wide-Field Composite Images of the Corneal Subbasal Layer by In Vivo Confocal Microscopy Free
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Ahmad Kheirkhah; Rodrigo Muller; Janine Mikolajczak; Ai Ren; Ella Maria Kadas; Hanna Zimmermann; Harald Pruess; Friedemann Paul; Alexander U. Brandt; Pedram Hamrah
Tags: cornea, microscopy, confocal, neurons, eye
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5801-5807. doi:https://doi.org/10.1167/iovs.15-17434
An Immunohistochemical Study of Inflammatory Cell Changes and Matrix Remodeling With and Without Acute Hydrops in Keratoconus Free
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Jennifer C. Fan Gaskin; I-Ping Loh; Charles N. J. McGhee; Trevor Sherwin
Tags: edema, keratoconus, cornea, inflammatory cells, body tissue
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5831-5837. doi:https://doi.org/10.1167/iovs.14-15123
Inhibition of Lymphangiogenesis and Hemangiogenesis in Corneal Inflammation by Subconjunctival Prox1 siRNA Injection in Rats Free
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Chang Rae Rho; Jun-Sub Choi; Minkoo Seo; Suk Kyeong Lee; Choun-Ki Joo
Tags: cornea, lymphangiogenesis, rna, small interfering, alkalies, keratitis
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5871-5879. doi:https://doi.org/10.1167/iovs.14-14433
Vitamin D in Tear Fluid Free
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Xiaowen Lu; Rodolfo A. Elizondo; Rikke Nielsen; Erik I. Christensen; Jun Yang; Bruce D. Hammock; Mitchell A. Watsky
Tags: intrinsic factor-cobalamin receptor, ldl-receptor related protein 2, mice, vitamin d, diet
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5880-5887. doi:https://doi.org/10.1167/iovs.15-17177
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model Free
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Achim H. Krauss; Rosa M. Corrales; Flavia S. A. Pelegrino; Johanna Tukler-Henriksson; Stephen C. Pflugfelder; Cintia S. de Paiva
Tags: antagonists, cell adhesion, cornea, dry eye syndromes, integrins
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5888-5895. doi:https://doi.org/10.1167/iovs.15-17249
Directional Posterior Corneal Profile Changes in Fuchs' Endothelial Corneal Dystrophy Free
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Katrin Wacker; Jay W. McLaren; Sanjay V. Patel
Tags: cornea, hereditary corneal dystrophy, endothelium, astigmatism
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5904-5911. doi:https://doi.org/10.1167/iovs.15-17311
Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study Free
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Joelle A. Hallak; Sapna Tibrewal; Neil Mohindra; Xiaoyi Gao; Sandeep Jain
Tags: brain-derived neurotrophic factor, deoxyribonuclease i, depressive disorders, dry eye syndromes, genes
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5990-5996. doi:https://doi.org/10.1167/iovs.15-17036
New Details of the Human Corneal Limbus Revealed With Second Harmonic Generation Imaging Free
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Choul Yong Park; Jimmy K. Lee; Cheng Zhang; Roy S. Chuck
Tags: collagen, cornea, diagnostic imaging, harmonics, limbus corneae
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6058-6066. doi:https://doi.org/10.1167/iovs.15-16783
Effect of the Rho Kinase Inhibitor Y-27632 on Corneal Endothelial Wound Healing Free
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Naoki Okumura; Ryota Inoue; Yugo Okazaki; Shinichiro Nakano; Hiroko Nakagawa; Shigeru Kinoshita; Noriko Koizumi
Tags: cornea, endothelium, eyedrops, wound healing, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6067-6074. doi:https://doi.org/10.1167/iovs.15-17595

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome Free
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Soh Youn Suh; Alan Le; Joseph L. Demer
Tags: brown tendon sheath syndrome, muscle of orbit, superior oblique muscle, magnetic resonance imaging, eye
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6114-6120. doi:https://doi.org/10.1167/iovs.15-17276
Pax7-Positive Cells/Satellite Cells in Human Extraocular Muscles Free
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Mona Lindström; Anton E. Tjust; Fatima Pedrosa Domellöf
Tags: limb, muscle, muscle of orbit, muscle satellite cell, neural cell adhesion molecules
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6132-6143. doi:https://doi.org/10.1167/iovs.15-16544

Genetics

LOXL1 Hypermethylation in Pseudoexfoliation Syndrome in the Uighur Population Free
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Hongfei Ye; Yongxiang Jiang; Qinghe Jing; Dan Li; Tuerhongjiang Maimaiti; Dilinuer Kasimu; Yi Lu
Tags: exfoliation syndrome, genes, hypermethylation, proteins, rna, messenger
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5838-5843. doi:https://doi.org/10.1167/iovs.15-16618
Frequent TERT Promoter Mutations in Ocular Surface Squamous Neoplasia Free
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Simone L. Scholz; Henning Thomasen; Henning Reis; Inga Möller; Raid Darawsha; Bettina Müller; Dirk Dekowski; Antje Sucker; Bastian Schilling; Dirk Schadendorf; Klaus-Peter Steuhl; Annette Paschen; Henrike Westekemper; Daniel Meller; Klaus G. Griewank
Tags: mutation, neoplasms, ocular surface squamous neoplasia
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5854-5861. doi:https://doi.org/10.1167/iovs.15-17469
Association of ERAP1 Gene Polymorphisms With Behçet's Disease in Han Chinese Free
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Lijun Zhang; Hongsong Yu; Minming Zheng; Hua Li; Yunjia Liu; Aize Kijlstra; Peizeng Yang
Tags: behcet syndrome, chinese (other dialects), chinese people, erap1 gene, polymorphism
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6029-6035. doi:https://doi.org/10.1167/iovs.15-17544

Glaucoma

Lamina Cribrosa Depth Variation Measured by Spectral-Domain Optical Coherence Tomography Within and Between Four Glaucomatous Optic Disc Phenotypes Free
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Yu Sawada; Masanori Hangai; Katsuyuki Murata; Makoto Ishikawa; Takeshi Yoshitomi
Tags: cribriform plate, eye, glaucoma, optic disk, optical coherence tomography
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5777-5784. doi:https://doi.org/10.1167/iovs.14-15942
Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina Free
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Xiangjun Yang; Gözde Hondur; Ming Li; Jian Cai; Jon B. Klein; Markus H. Kuehn; Gülgün Tezel
Tags: ocular hypertension, proteomics, retina, risk factors, proteins
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5816-5830. doi:https://doi.org/10.1167/iovs.15-17294
Bleb Analysis and Short-Term Results of Biodegradable Collagen Matrix–Augmented Ahmed Glaucoma Valve Implantation: 6-Month Follow-up Free
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Seungsoo Rho; Youngje Sung; Kyoung Tak Ma; Sae Heun Rho; Chan Yun Kim
Tags: blister, collagen, follow-up, glaucoma, implantation procedure
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5896-5903. doi:https://doi.org/10.1167/iovs.15-17480
Customizing Structure–Function Displacements in the Macula for Individual Differences Free
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Andrew Turpin; Siyuan Chen; Juan A. Sepulveda; Allison M. McKendrick
Tags: displacements, macula densa, macula lutea
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5984-5989. doi:https://doi.org/10.1167/iovs.15-17384
The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage Free
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Ji-Woong Lee; Eun-Ah Kim; Francisco Otarola; Esteban Morales; Fei Yu; Abdelmonem A. Afifi; Kouros Nouri-Mahdavi; Joseph Caprioli
Tags: glaucoma, visual fields
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5997-6006. doi:https://doi.org/10.1167/iovs.15-17006
Suppression of Type I Collagen Expression by miR-29b Via PI3K, Akt, and Sp1 Pathway, Part II: An In Vivo Investigation Free
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Juan Yu; Haomin Luo; Ning Li; Xuanchu Duan
Tags: 1-phosphatidylinositol 3-kinase, blister, collagen type i, phosphoinositide 3-kinase, proto-oncogene proteins c-akt
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6019-6028. doi:https://doi.org/10.1167/iovs.15-16558
More Accurate Modeling of Visual Field Progression in Glaucoma: ANSWERS Free
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Haogang Zhu; David P. Crabb; Tuan Ho; David F. Garway-Heath
Tags: false-positive results, glaucoma, visual fields, linear regression
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6077-6083. doi:https://doi.org/10.1167/iovs.15-16957
Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells Free
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Shaoqing He; Yong H. Park; Thomas Yorio; Raghu R. Krishnamoorthy
Tags: endothelin-1, endothelin-3, endothelins, gene expression, genes
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6144-6161. doi:https://doi.org/10.1167/iovs.15-16569
Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma Free
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Shaodan Zhang; Bo Wang; Yuan Xie; SenHua Zhu; Ravi Thomas; Guoping Qing; Chun Zhang; Ningli Wang
Tags: cerebral blood flow, gray matter, open-angle glaucoma, primary visual cortex, volume
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6171-6178. doi:https://doi.org/10.1167/iovs.15-17286
Relationship Between Location of Retinal Nerve Fiber Layer Defect and Curvature of Retinal Artery Trajectory in Eyes With Normal Tension Glaucoma Free
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Takehiro Yamashita; Koji Nitta; Shozo Sonoda; Kazuhisa Sugiyama; Taiji Sakamoto
Tags: central retinal artery, eye, low tension glaucoma, retinal nerve fiber layer, glaucoma
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6190-6195. doi:https://doi.org/10.1167/iovs.15-17119

Multidisciplinary Ophthalmic Imaging

Retinal and Choroidal Folds in Papilledema Free
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Patrick A. Sibony; Mark J. Kupersmith; Steven E. Feldon; Jui-Kai Wang; Mona Garvin; OCT Substudy Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial
Tags: choroidal fold, eye, optic disk, papilledema, skin wrinkling
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5670-5680. doi:https://doi.org/10.1167/iovs.15-17459
Assessment of Different Sampling Methods for Measuring and Representing Macular Cone Density Using Flood-Illuminated Adaptive Optics Free
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Shu Feng; Michael J. Gale; Jonathan D. Fay; Ambar Faridi; Hope E. Titus; Anupam K. Garg; Keith V. Michaels; Laura R. Erker; Dawn Peters; Travis B. Smith; Mark E. Pennesi
Tags: diagnostic imaging, retinal cone, sampling method, floods, optics
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5751-5763. doi:https://doi.org/10.1167/iovs.15-16954
Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography Free
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Conor Leahy; Harsha Radhakrishnan; Geoffrey Weiner; Jeffrey L. Goldberg; Vivek J. Srinivasan
Tags: angiogram, vasculature, dilatation, pathologic, optical coherence tomography, blood capillaries
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5785-5793. doi:https://doi.org/10.1167/iovs.15-17210

Physiology and Pharmacology

Strain and Age Effects on Aqueous Humor Dynamics in the Mouse Free
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J. Cameron Millar; Tien N. Phan; Iok-Hou Pang; Abbot F. Clark
Tags: aqueous humor, fluorescein-5-isothiocyanate, intraocular pressure, mice, perfusion
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5764-5776. doi:https://doi.org/10.1167/iovs.15-16720
Impact of Cationic Amino Acid Transporter 1 on Blood-Retinal Barrier Transport of L-Ornithine Free
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Yoshiyuki Kubo; Akiko Obata; Shin-ichi Akanuma; Ken-ichi Hosoya
Tags: biological transport, cationic amino acid transporter 1, ornithine, blood-retinal barrier, proteins
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5925-5932. doi:https://doi.org/10.1167/iovs.15-17398

Retina

Subfoveal Choroidal Thickness Changes Following Anti-Vascular Endothelial Growth Factor Therapy in Myopic Choroidal Neovascularization Free
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Seong Joon Ahn; Kyu Hyung Park; Se Joon Woo
Tags: choroidal neovascularization, eye, recurrence
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5794-5800. doi:https://doi.org/10.1167/iovs.14-16006
In Vivo Imaging of Retinal Oxidative Stress Using a Reactive Oxygen Species–Activated Fluorescent Probe Free
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Megan C. Prunty; Moe H. Aung; Adam M. Hanif; Rachael S. Allen; Micah A. Chrenek; Jeffrey H. Boatright; Peter M. Thule; Kousik Kundu; Niren Murthy; Machelle T. Pardue
Tags: diagnostic imaging, fluorescence, fluorescent probes, oxidative stress, reactive oxygen species
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5862-5870. doi:https://doi.org/10.1167/iovs.15-16810
Predicting Progression of ABCA4-Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front Free
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Artur V. Cideciyan; Malgorzata Swider; Sharon B. Schwartz; Edwin M. Stone; Samuel G. Jacobson
Tags: laplace transform damping factor for arterial velocity waveform, laser-doppler flowmetry, meridians, nose, retina
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5946-5955. doi:https://doi.org/10.1167/iovs.15-17698
Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration Free
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Rodrigo Matsui; Artur V. Cideciyan; Sharon B. Schwartz; Alexander Sumaroka; Alejandro J. Roman; Malgorzata Swider; Wei Chieh Huang; Rebecca Sheplock; Samuel G. Jacobson
Tags: cohort studies, heterogeneity, pathophysiology, retinal degeneration, rod photoreceptors
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6007-6018. doi:https://doi.org/10.1167/iovs.15-17174
HLA Associations in a Cohort of Children With Juvenile Idiopathic Arthritis With and Without Uveitis Free
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Sheila T. Angeles-Han; Courtney McCracken; Steven Yeh; Se Ryeong Jang; Kirsten Jenkins; Spencer Cope; John Bohnsack; Aimee Hersh; Susan D. Thompson; Sampath Prahalad
Tags: arthritis, juvenile rheumatoid, child, cohort studies, human leukocyte antigens, uveitis
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6043-6048. doi:https://doi.org/10.1167/iovs.15-17168
Hypoxia Activates Calpains in the Nerve Fiber Layer of Monkey Retinal Explants Free
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Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma
Tags: calpain, cercopithecidae, hypoxia, nerve fibers
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6049-6057. doi:https://doi.org/10.1167/iovs.15-17360
Pgc-1α and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina Free
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Stefanie Kunst; Tanja Wolloscheck; Debra K. Kelleher; Uwe Wolfrum; S. Anna Sargsyan; P. Michael Iuvone; Kenkichi Baba; Gianluca Tosini; Rainer Spessert
Tags: dopamine, melatonin, mice, retina, transcription, genetic
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6084-6094. doi:https://doi.org/10.1167/iovs.15-17503
Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer Free
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Francisco M. Nadal-Nicolás; Paloma Sobrado-Calvo; Manuel Jiménez-López; Manuel Vidal-Sanz; Marta Agudo-Barriuso
Tags: axotomy, ganglia, optic nerve, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6095-6112. doi:https://doi.org/10.1167/iovs.15-17195
Repeatability of Cone Spacing Measures in Eyes With Inherited Retinal Degenerations Free
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Shiri Zayit-Soudry; Nicolas Sippl-Swezey; Travis C. Porco; Stephanie K. Lynch; Reema Syed; Kavitha Ratnam; Moreno Menghini; Austin J. Roorda; Jacque L. Duncan
Tags: eye, retinal cone, retinal degeneration
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6179-6189. doi:https://doi.org/10.1167/iovs.15-17010

Retinal Cell Biology

Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Müller Glial Cells Free
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María V. Simón; Facundo H. Prado Spalm; Luis E. Politi; Nora P. Rotstein
Tags: neuroglia, retina, sphingosine-1-phosphate phosphatase
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5808-5815. doi:https://doi.org/10.1167/iovs.14-16195
Baicalein Inhibits Amadori-Glycated Albumin-Induced MCP-1 Expression in Retinal Ganglion Cells via a MicroRNA-124–Dependent Mechanism Free
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Ning Dong; Bing Xu; Hong Shi; Xin Tang
Tags: albumins, micrornas, monocyte chemoattractant protein-1, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5844-5853. doi:https://doi.org/10.1167/iovs.15-17444
Alpha2-Adrenergic–Agonist Brimonidine Stimulates Negative Feedback and Attenuates Injury-Induced Phospho-ERK and Dedifferentiation of Chicken Müller Cells Free
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Mohammad Harun-Or-Rashid; Marta Díaz-DelCastillo; Caridad Galindo-Romero; Finn Hallböök
Tags: anaplasia, brimonidine, feedback, wounds and injuries, chickens
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5933-5945. doi:https://doi.org/10.1167/iovs.15-16816
Substrate Elastic Modulus Regulates the Morphology, Focal Adhesions, and α-Smooth Muscle Actin Expression of Retinal Müller Cells Free
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Shao-Chong Bu; Roel Kuijer; Roelofje J. van der Worp; Sander M. van Putten; Olaf Wouters; Xiao-Rong Li; Johanna M. M. Hooymans; Leonoor I. Los
Tags: actins, cellular morphology, elasticity, focal adhesions, language morphology
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5974-5982. doi:https://doi.org/10.1167/iovs.14-15969

Visual Neuroscience

Blue Light Protects Against Temporal Frequency Sensitive Refractive Changes Free
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Frances Rucker; Stephanie Britton; Molly Spatcher; Stephan Hanowsky
Tags: lighting, myopia, eye, light
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6121-6131. doi:https://doi.org/10.1167/iovs.15-17238

Visual Psychophysics and Physiological Optics

Relative Peripheral Hyperopia Does Not Predict Development and Progression of Myopia in Children Free
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David A. Atchison; Shi-Ming Li; He Li; Si-Yuan Li; Luo-Ru Liu; Meng-Tian Kang; Bo Meng; Yun-Yun Sun; Si-Yan Zhan; Paul Mitchell; Ningli Wang
Tags: child, hyperopia, myopia, refraction
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6162-6170. doi:https://doi.org/10.1167/iovs.15-17200

Letters to the Editor

Analytic Formulas on Factors Determining the Safety and Efficacy in UV-Light-Sensitized Corneal Cross-Linking Free
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Jui-teng Lin
Tags: burkina faso, safety, ultraviolet rays
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5740-5741. doi:https://doi.org/10.1167/iovs.15-17537
Author Response: Analytic Formulas on Factors Determining the Safety and Efficacy in UV-Light-Sensitized Corneal Cross-Linking Free
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Maria Laggner; Andreas Pollreisz; Gerald Schmidinger; Ruth A. Byrne; Clemens Scheinecker; Ursula Schmidt-Erfurth; Ying-Ting Chen
Tags: burkina faso, safety, ultraviolet rays
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5742. doi:https://doi.org/10.1167/iovs.15-17718
Total Corneal Astigmatism Measurement Precision Free
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Virgilio Galvis; Alejandro Tello; Camilo A. Niño; Maria Margarita Parra
Tags: astigmatism, cornea, precision
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5912. doi:https://doi.org/10.1167/iovs.15-17735
Author Response: Total Corneal Astigmatism Measurement Precision Free
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Giacomo Savini; Kristian Næser
Tags: astigmatism, cornea, precision
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5913. doi:https://doi.org/10.1167/iovs.15-17849
Reticular Pseudodrusen: A Common Pathogenic Mechanism Affecting the Choroid–Bruch's Membrane Complex and Retinal Pigment Epithelium for Different Retinal and Macular Diseases Free
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Giuseppe Querques
Tags: bruch's basal membrane, choroid, macular disorders, retinal pigment epithelium
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5914-5915. doi:https://doi.org/10.1167/iovs.15-17133
Author Response: Reticular Pseudodrusen: A Common Pathogenic Mechanism Affecting the Choroid–Bruch's Membrane Complex and Retinal Pigment Epithelium for Different Retinal and Macular Dise... Free
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Martin Gliem; Frank G. Holz; Peter Charbel Issa
Tags: bruch's basal membrane, choroid, macular disorders, retinal pigment epithelium
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5916. doi:https://doi.org/10.1167/iovs.15-17898
Human Accommodative Ciliary Muscle Configuration Changes Are Consistent With Schachar's Mechanism of Accommodation Free
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Ronald A. Schachar
Tags: ciliary muscle, visual accommodation
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6075. doi:https://doi.org/10.1167/iovs.15-17452
Author Response: Human Accommodative Ciliary Muscle Configuration Changes Are Consistent With Schachar's Mechanism of Accommodation Free
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Yilei Shao; Aizhu Tao; Hong Jiang; Xinjie Mao; Jianguang Zhong; Meixiao Shen; Fan Lu; Zhe Xu; Carol L. Karp; Jianhua Wang
Tags: ciliary muscle, visual accommodation
Investigative Ophthalmology & Visual Science September 2015, Vol.56, 6076-000. doi:https://doi.org/10.1167/iovs.15-17903

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5739. doi:https://doi.org/10.1167/iovs.15982a
Erratum Free
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Investigative Ophthalmology & Visual Science September 2015, Vol.56, 5983. doi:https://doi.org/10.1167/iovs.14-16350a
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