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Research Highlight

Automated Perimetry Under the Microscope: A Re-Examination of Fundamental Assumptions Free
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Shaban Demirel
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7224. doi:https://doi.org/10.1167/iovs.15-18029
Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections Free
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Thomas Langmann
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7387. doi:https://doi.org/10.1167/iovs.15-18268
Adult Human Choroid: An Alymphatic Tissue? Free
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Gerard A. Lutty
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7417. doi:https://doi.org/10.1167/iovs.15-18531

Anatomy and Pathology/Oncology

ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma Free
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Manuel F. Bande; María Santiago; Purificacion Mera; Josep María Piulats; María Jose Blanco; María Xosé Rodríguez-Álvarez; Carmela Capeans; Antonio Piñeiro; María Pardo
Tags: biological markers, pmel17, uveal melanoma
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7007-7011. doi:https://doi.org/10.1167/iovs.15-17183
Lymphatic Markers in the Adult Human Choroid Free
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Falk Schrödl; Alexandra Kaser-Eichberger; Andrea Trost; Clemens Strohmaier; Barbara Bogner; Christian Runge; Karolina Motloch; Daniela Bruckner; Martin Laimer; Ludwig M. Heindl; Herbert A. Reitsamer
Tags: adult, choroid, lymphatic vessels
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7406-7416. doi:https://doi.org/10.1167/iovs.15-17883

Biochemistry and Molecular Biology

Proteomic Analysis of Embryonic and Young Human Vitreous Free
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Kenneth M. P. Yee; Edward P. Feener; Michele Madigan; Nicholas J. Jackson; Ben-Bo Gao; Fred N. Ross-Cisneros; Jan Provis; Lloyd Paul Aiello; Alfredo A. Sadun; J. Sebag
Tags: embryo, proteins, proteomics, vitreous body, immunohistochemistry
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7036-7042. doi:https://doi.org/10.1167/iovs.15-16809

Clinical and Epidemiologic Research

The Associations of Dietary Intake of Polyunsaturated Fatty Acids With Diabetic Retinopathy in Well-Controlled Diabetes Free
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Mariko Sasaki; Ryo Kawasaki; Sophie Rogers; Ryan Eyn Kidd Man; Katsumasa Itakura; Jing Xie; Victoria Flood; Kazuo Tsubota; Ecosse Lamoureux; Jie Jin Wang
Tags: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, diet, polyunsaturated fatty acids
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7473-7479. doi:https://doi.org/10.1167/iovs.15-17485
Sex Differences in the Relationship Between Obesity and Choroidal Nevus in US Adults Free
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Rebecca M. Sieburth; Mary Qiu; Carol L. Shields
Tags: adult, nevus of choroid, obesity, sex characteristics, body mass index procedure
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7489-7495. doi:https://doi.org/10.1167/iovs.15-17803

Cornea

Evaluation of Oxidative Stress Markers in Human Conjunctival Epithelial Cells Exposed to Diesel Exhaust Particles (DEP) Free
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Romina M. Lasagni Vitar; Julia Tau; Claudia G. Reides; Alejandro Berra; Sandra M. Ferreira; Susana F. Llesuy
Tags: antioxidants, conjunctival epithelial cells, diesel exhaust, oxidative stress, proteins
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7058-7066. doi:https://doi.org/10.1167/iovs.15-16864
Quantifying Ocular Surface Inflammation and Correlating It With Inflammatory Cell Infiltration In Vivo: A Novel Method Free
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Giulio Ferrari; Alessandro Rabiolo; Fabio Bignami; Federico Sizzano; Alessio Palini; Chiara Villa; Paolo Rama
Tags: erythema, eye, flow cytometry, inflammation, conjunctiva
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7067-7075. doi:https://doi.org/10.1167/iovs.15-17105
Corneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Study Free
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Ahmad Kheirkhah; Raheleh Rahimi Darabad; Andrea Cruzat; Amir Reza Hajrasouliha; Deborah Witkin; Nadia Wong; Reza Dana; Pedram Hamrah
Tags: cornea, dendritic cells, dry eye syndromes, epithelium, microscopy, confocal
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7179-7185. doi:https://doi.org/10.1167/iovs.15-17433
MicroRNA-184 Regulates Corneal Lymphangiogenesis Free
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Sammy Grimaldo; Don Yuen; Jaci Theis; Melissa Ng; Tatiana Ecoiffier; Lu Chen
Tags: cornea, lymphangiogenesis, micrornas, protein overexpression, adhesions
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7209-7213. doi:https://doi.org/10.1167/iovs.15-17733
Phenotypic Change and Induction of Cytokeratin Expression During In Vitro Culture of Corneal Stromal Cells Free
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Laura E. Sidney; Owen D. McIntosh; Andrew Hopkinson
Tags: cornea, epithelium, immunocytochemistry, keratins, keratocytes
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7225-7235. doi:https://doi.org/10.1167/iovs.15-17810
Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea Free
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Thabo Lapp; Sarah S. Zaher; Carolin T. Haas; David L. Becker; Chris Thrasivoulou; Benjamin M. Chain; Daniel F. P. Larkin; Mahdad Noursadeghi
Tags: chemokine receptors, cornea, donors, monocytes, wounds and injuries
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7250-7259. doi:https://doi.org/10.1167/iovs.15-16941
Automated Tear Film Surface Quality Breakup Time as a Novel Clinical Marker for Tear Hyperosmolarity in Dry Eye Disease Free
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Laura Elizabeth Downie
Tags: dry eye syndromes, tear film finding, osmolar concentration, schirmer tear test procedure
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7260-7268. doi:https://doi.org/10.1167/iovs.15-17772
The Role of Insulin-Like Growth Factor Binding Protein 2 (IGFBP2) in the Regulation of Corneal Fibroblast Differentiation Free
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Soo Hyun Park; Kyoung Woo Kim; Jae Chan Kim
Tags: cornea, fibroblasts, igfbp2 protein, human, regulation, phenotype
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7293-7302. doi:https://doi.org/10.1167/iovs.15-16616
Palate Lung Nasal Clone (PLUNC), a Novel Protein of the Tear Film: Three-Dimensional Structure, Immune Activation, and Involvement in Dry Eye Disease (DED) Free
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Martin, Schicht; Felix, Rausch; Martin, Beron; Christina, Jacobi; Fabian, Garreis; Nadine, Hartjen; Stephanie, Beileke; Friedrich, Kruse; Lars, Bräuer; Friedrich, Paulsen
Tags: dry eye syndromes, lung, proteins, tear film finding, nose
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7312-7323. doi:https://doi.org/10.1167/iovs.15-17560
Immunofluorescence Tomography of Mouse Ocular Surface Epithelial Stem Cells and Their Niche Microenvironment Free
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Geraint J. Parfitt; Behdad Kavianpour; Karen L. Wu; Yilu Xie; Donald J. Brown; James V. Jester
Tags: cornea, epithelial cells, epithelial stem cells, fluorescent antibody technique, mice
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7338-7344. doi:https://doi.org/10.1167/iovs.15-18038
Corneal Fibroblast Migration Patterns During Intrastromal Wound Healing Correlate With ECM Structure and Alignment Free
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W. Matthew Petroll; Pouriska B. Kivanany; Daniela Hagenasr; Eric K. Graham
Tags: cornea, diagnostic imaging, fibroblasts, wound healing, wounds and injuries
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7352-7361. doi:https://doi.org/10.1167/iovs.15-17978
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss Free
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Stephen C. Pflugfelder; Cintia S. De Paiva; Quianta L. Moore; Eugene A. Volpe; De-Quan Li; Koray Gumus; Mahira L. Zaheer; Rosa M. Corrales
Tags: conjunctiva, goblet cells, human leukocyte interferon, interferons, mucins
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7545-7550. doi:https://doi.org/10.1167/iovs.15-17627
Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Transiently Alters the Morphology of Corneal Endothelial Cells Free
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Naoki Okumura; Yugo Okazaki; Ryota Inoue; Shinichiro Nakano; Nigel J. Fullwood; Shigeru Kinoshita; Noriko Koizumi
Tags: chronic exertional compartment syndrome, cornea, endothelial cells, eyedrops, kinase inhibitors
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7560-7567. doi:https://doi.org/10.1167/iovs.15-17887

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Skewness of Fractional Anisotropy Detects Decreased White Matter Integrity Resulting From Acute Optic Neuritis Free
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Bradley G. Goodyear; Nourhan M. H. Zayed; Filomeno Cortese; Jessie Trufyn; Fiona Costello
Tags: anisotropy, eye, optic nerve, optic neuritis, personal integrity
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7597-7603. doi:https://doi.org/10.1167/iovs.15-17335

Genetics

Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation Free
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Celine J. Rocca; Alexander Kreymerman; Sarah N. Ur; Katie E. Frizzi; Swati Naphade; Athena Lau; Tammy Tran; Nigel A. Calcutt; Jeffrey L. Goldberg; Stephanie Cherqui
Tags: cornea, ctns gene, eye, fanconi syndrome, mice
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7214-7223. doi:https://doi.org/10.1167/iovs.15-17107
A Nonsense Mutation in FAM161A Is a Recurrent Founder Allele in Dutch and Belgian Individuals With Autosomal Recessive Retinitis Pigmentosa Free
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Kristof Van Schil; B. Jeroen Klevering; Bart P. Leroy; Jan Willem R. Pott; Dikla Bandah-Rozenfeld; Marijke N. Zonneveld-Vrieling; Dror Sharon; Anneke I. den Hollander; Frans P. M. Cremers; Elfride De Baere; Rob W. J. Collin; L. Ingeborgh van den Born
Tags: alleles, autosomal recessive inheritance, mutation, mutation, nonsense, recurrence
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7418-7426. doi:https://doi.org/10.1167/iovs.15-17920

Glaucoma

Comparison of the Pattern of Retinal Ganglion Cell Damage Between Patients With Compressive and Glaucomatous Optic Neuropathies Free
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Eun Ji Lee; Hee Kyung Yang; Tae-Woo Kim; Jeong-Min Hwang; Young-Hoon Kim; Chae-Yong Kim
Tags: glaucoma, optic nerve disorders, retinal ganglion cells, nose, optic disk
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7012-7020. doi:https://doi.org/10.1167/iovs.15-17909
Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study Free
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Louis R. Pasquale; Akiko Hanyuda; Ai Ren; Michael Giovingo; Scott H. Greenstein; Clara Cousins; Thomas Patrianakos; Angelo P. Tanna; Christopher Wanderling; William Norkett; Janey L. Wiggs; Kelsey Green; Jae H. Kang; Paul A. Knepper
Tags: blood capillaries, glaucoma, open-angle glaucoma, hemorrhage
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7021-7028. doi:https://doi.org/10.1167/iovs.15-17860
Ophthalmoscopic-Perspectively Distorted Optic Disc Diameters and Real Disc Diameters Free
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Yi Dai; Jost B. Jonas; Zhihong Ling; Xinghuai Sun
Tags: ophthalmoscopy, optic disk, diameter
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7076-7083. doi:https://doi.org/10.1167/iovs.14-16033
Profiling of Cytokines Secreted by Conventional Aqueous Outflow Pathway Endothelial Cells Activated In Vitro and Ex Vivo With Laser Irradiation Free
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Jorge A. Alvarado; Phuonglan Chau; Jianfeng Wu; Richard Juster; Amde Selassie Shifera; Michael Geske
Tags: cytokine, cytokine gene, lasers, signal pathway, signal transduction pathways
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7100-7108. doi:https://doi.org/10.1167/iovs.15-17660
Compromised Optic Nerve Blood Flow and Autoregulation Secondary to Neural Degeneration Free
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Grant Cull; Reinhard Told; Claude F. Burgoyne; Simon Thompson; Brad Fortune; Lin Wang
Tags: eye, hemodynamics, homeostasis, intraocular pressure, nerve degeneration
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7286-7292. doi:https://doi.org/10.1167/iovs.15-17879
Clinical Significance of the Location of Recurrent Optic Disc Hemorrhage in Glaucoma Free
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Hae-Young Lopilly Park; Eun Kyoung Kim; Chan Kee Park
Tags: glaucoma, hemorrhage, optic disk, recurrence, eye
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7524-7534. doi:https://doi.org/10.1167/iovs.15-17502

Immunology and Microbiology

Inhibitory Effects of 2,2′-Dipyridyl and 1,2,3,4,6-Penta-O-Galloyl-b-D-Glucopyranose on Biofilm Formation in Contact Lens Cases Free
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Pauline Cho; Guang-Sen Shi; Maureen Boost
Tags: 2,2'-dipyridyl, biofilms, contact lens storage case, pentachlorophenol
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7053-7057. doi:https://doi.org/10.1167/iovs.15-17723
Blood–Retinal Barrier Compromise and Endogenous Staphylococcus aureus Endophthalmitis Free
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Phillip S. Coburn; Brandt J. Wiskur; Roger A. Astley; Michelle C. Callegan
Tags: blood-retinal barrier, diabetes mellitus, endophthalmitis, eye, infections
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7303-7311. doi:https://doi.org/10.1167/iovs.15-17488
Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands Free
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Holly R. Chinnery; Cecilia NaranjoGolborne; Cheng M. Leong; Weisan Chen; John V. Forrester; Paul G. McMenamin
Tags: administration, topical, eye, ligands, mice, microglia
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7377-7386. doi:https://doi.org/10.1167/iovs.15-17587
Distinct Profiles of Soluble Cytokine Receptors Between B-Cell Vitreoretinal Lymphoma and Uveitis Free
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Atsunobu Takeda; Hiroshi Yoshikawa; Takako Fukuhara; Shin-Ichi Hikita; Kuniaki Hijioka; Takaaki Otomo; Ryoichi Arita; Toshio Hisatomi; Kazuhiro Kimura; Shigeo Yoshida; Yo-Ichi Kawano; Koh-Hei Sonoda; Tatsuro Ishibashi
Tags: b-lymphocytes, cytokine, lymphoma, pmel17, receptors, cytokine
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7516-7523. doi:https://doi.org/10.1167/iovs.15-17465

Lens

Active Maintenance of the Gradient of Refractive Index Is Required to Sustain the Optical Properties of the Lens Free
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Ehsan Vaghefi; Andy Kim; Paul J. Donaldson
Tags: lens (device), lens, crystalline, optics, cattle, refractive index
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7195-7208. doi:https://doi.org/10.1167/iovs.15-17861
MALDI Imaging Mass Spectrometry Spatially Maps Age-Related Deamidation and Truncation of Human Lens Aquaporin-0 Free
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Jamie L. Wenke; Kristie L. Rose; Jeffrey M. Spraggins; Kevin L. Schey
Tags: diagnostic imaging, lens (device), lens, crystalline, mass spectrometry, peptides
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7398-7405. doi:https://doi.org/10.1167/iovs.15-18117

Low Vision

Objective Analysis of Performance of Activities of Daily Living in People With Central Field Loss Free
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Shahina Pardhan; Keziah Latham; Daryl Tabrett; Matthew A. Timmis
Tags: activities of daily living, bone plates, calcaneofibular ligament, food, vision
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7169-7178. doi:https://doi.org/10.1167/iovs.15-16556
Outcomes of Multidisciplinary Low Vision Rehabilitation in Adults Free
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Vijaya K. Gothwal; Seelam Bharani
Tags: adult, blind rehabilitation therapy, visual impairment, mobility
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7451-7461. doi:https://doi.org/10.1167/iovs.15-16892
Prehension of a Flanked Target in Individuals With Amblyopia Free
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John G. Buckley; Ian E. Pacey; Gurvinder K. Panesar; Andrew, Scally; Brendan T. Barrett
Tags: amblyopia
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7568-7580. doi:https://doi.org/10.1167/iovs.15-16860

Multidisciplinary Ophthalmic Imaging

A Novel, Real-Time, In Vivo Mouse Retinal Imaging System Free
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Mark C. Butler; Jack M. Sullivan
Tags: clinically isolated syndrome, diagnostic imaging, mice, retinal imaging, injections
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7159-7168. doi:https://doi.org/10.1167/iovs.14-16370
Visible Versus Near-Infrared Optical Performance of Diffractive Multifocal Intraocular Lenses Free
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Fidel Vega; María S. Millán; Núria Vila-Terricabras; Francisco Alba-Bueno
Tags: intraocular lens implant device, optics, vaccine information sheets, light, lighting
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7345-7351. doi:https://doi.org/10.1167/iovs.15-17664
Cerenkov Luminescence Imaging for Accurate Placement of Radioactive Plaques in Episcleral Brachytherapy of Intraocular Tumors Free
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Johan Axelsson; Jørgen Krohn
Tags: brachytherapy, diagnostic imaging, eye, eye neoplasms, luminescence
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7362-7368. doi:https://doi.org/10.1167/iovs.15-18012
Melanin Pigmentation in Rat Eyes: In Vivo Imaging by Polarization-Sensitive Optical Coherence Tomography and Comparison to Histology Free
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Bernhard Baumann; Johannes Schirmer; Sabine Rauscher; Stanislava Fialová; Martin Glösmann; Marco Augustin; Michael Pircher; Marion Gröger; Christoph K. Hitzenberger
Tags: albinism, depolarization, diagnostic imaging, eye, histology
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7462-7472. doi:https://doi.org/10.1167/iovs.15-17742

Nantotechnology and Regenerative Medicine

Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells Free
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Thelma Y. Garcia; Mark Gutierrez; Joseph Reynolds; Deepak A. Lamba
Tags: oxidative stress, retinal pigment cell, european society of cardiology
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7480-7488. doi:https://doi.org/10.1167/iovs.15-17251
Control of Maintenance and Regeneration of Planarian Eyes by ovo Free
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Samuel D. Cross; Adiv A. Johnson; Benjamin J. Gilles; Lori A. Bachman; Takeshi Inoue; Kiyokazu Agata; Lihua Y. Marmorstein; Alan D. Marmorstein
Tags: eye, rna interference, planarians
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7604-7610. doi:https://doi.org/10.1167/iovs.15-17458

Physiology and Pharmacology

A Comparative Treatment Study of Intravitreal Voriconazole and Liposomal Amphotericin B in an Aspergillus fumigatus Endophthalmitis Model Free
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Jinsong Zhao; Yan Cheng; Xiande Song; Chenguang Wang; Guanfang Su; Zaoxia Liu
Tags: amphotericin b liposomal, aspergillus fumigatus, endophthalmitis, liposomes, voriconazole
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7369-7376. doi:https://doi.org/10.1167/iovs.15-17266
Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats Free
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Youngseok Song; Taiji Nagaoka; Takafumi Yoshioka; Seigo Nakabayashi; Tomofumi Tani; Akitoshi Yoshida
Tags: cats, erythema, intravitreal injections, neuroglia, photopsia
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7551-7559. doi:https://doi.org/10.1167/iovs.15-17676

Retina

The Negative Cone Mosaic: A New Manifestation of the Optical Stiles-Crawford Effect in Normal Eyes Free
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Chahira Miloudi; Florence Rossant; Isabelle Bloch; Céline Chaumette; Alexandre Leseigneur; José-Alain Sahel; Serge Meimon; Sarah Mrejen; Michel Paques
Tags: eye, mosaicism, optics, retinal cone
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7043-7050. doi:https://doi.org/10.1167/iovs.15-17022
Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model Free
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Sharee Kuny; Woo Jung Cho; Ioannis S. Dimopoulos; Yves Sauvé
Tags: macular dystrophy, mice, mice, transgenic, photoreceptors, proteins
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7109-7121. doi:https://doi.org/10.1167/iovs.15-17567
Full-Field Pupillary Light Responses, Luminance Thresholds, and Light Discomfort Thresholds in CEP290 Leber Congenital Amaurosis Patients Free
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Frederick T. Collison; Jason C. Park; Gerald A. Fishman; J. Jason McAnany; Edwin M. Stone
Tags: leber's amaurosis, luminance, pupil, pupillometry, retinal cone
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7130-7136. doi:https://doi.org/10.1167/iovs.15-17467
Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo Free
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Tao Li; Bogale Aredo; Kaiyan Zhang; Xin Zhong; Jose S. Pulido; Shusheng Wang; Yu-Guang He; Xianming Huang; Rolf A. Brekken; Rafael L. Ufret-Vincenty
Tags: antibodies, choroidal neovascularization, phosphatidylserines, angiogenesis, lasers
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7137-7145. doi:https://doi.org/10.1167/iovs.15-17302
N-Methyl-N-Nitrosourea–Induced Acute Alteration of Retinal Function and Morphology in Monkeys Free
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Junzo Kinoshita; Noriaki Iwata; Takanori Maejima; Masako Imaoka; Tomofumi Kimotsuki; Mitsuya Yasuda
Tags: cercopithecidae, electroretinography, nitrosourea compounds, retina, retinal cone
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7146-7158. doi:https://doi.org/10.1167/iovs.15-16929
Contrast Sensitivity With a Subretinal Prosthesis and Implications for Efficient Delivery of Visual Information Free
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Georges Goetz; Richard Smith; Xin Lei; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Alexander Sher; Daniel Palanker
Tags: contrast sensitivity, prostheses, retina, implants
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7186-7194. doi:https://doi.org/10.1167/iovs.15-17566
Progressive Thinning of Regional Macular Thickness After Epiretinal Membrane Surgery Free
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Kazuyuki Kumagai; Masanori Hangai; Nobuchika Ogino
Tags: epiretinal membrane, surgical procedures, operative, surgery specialty, postoperative care
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7236-7242. doi:https://doi.org/10.1167/iovs.15-17794
Pathologic Changes of Cone Photoreceptors in Eyes With Occult Macular Dystrophy Free
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Ayami Nakanishi; Shinji Ueno; Kenichi Kawano; Yasuki Ito; Taro Kominami; Shunsuke Yasuda; Mineo Kondo; Kazushige Tsunoda; Takeshi Iwata; Hiroko Terasaki
Tags: eye, macular dystrophy, retinal cone
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7243-7249. doi:https://doi.org/10.1167/iovs.15-16742
Phenotype Characteristics of Fellow Eyes in Patients With Early Onset of Neovascular Age-Related Macular Degeneration Free
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Tina Schick; Lebriz Ersoy; Carel B. Hoyng; Bernd Kirchhof; Sandra Liakopoulos
Tags: choroidal neovascularization, exudative age-related macular degeneration, eye, phenotype, drusen
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7269-7273. doi:https://doi.org/10.1167/iovs.15-16989
Quantitative Fundus Autofluorescence and Optical Coherence Tomography in ABCA4 Carriers Free
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Tobias Duncker; Gregory E. Stein; Winston Lee; Stephen H. Tsang; Jana Zernant; Srilaxmi Bearelly; Donald C. Hood; Vivienne C. Greenstein; François C. Delori; Rando Allikmets; Janet R. Sparrow
Tags: fundus autofluorescence imaging, mutation, optical coherence tomography, heterozygote, eye
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7274-7285. doi:https://doi.org/10.1167/iovs.15-17371
Membrane Peeling-Induced Retinal Alterations on Intraoperative OCT in Vitreomacular Interface Disorders From the PIONEER Study Free
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Justis P. Ehlers; Jaehong Han; Daniel Petkovsek; Peter K. Kaiser; Rishi P. Singh; Sunil K. Srivastava
Tags: intraoperative care, surgical procedures, operative, tissue membrane, forceps, eye
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7324-7330. doi:https://doi.org/10.1167/iovs.15-17526
In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device Free
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Kevin D. Lance; Samuel D. Good; Thaís S. Mendes; Mynna Ishikiriyama; Patrick Chew; Laurel S. Estes; Kazuhito Yamada; Sri Mudumba; Robert B. Bhisitkul; Tejal A. Desai
Tags: rapamycin
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7331-7337. doi:https://doi.org/10.1167/iovs.15-17757
Retinal Vascular Fractals Correlate With Early Neurodegeneration in Patients With Type 2 Diabetes Mellitus Free
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Ulrik Frydkjaer-Olsen; Rasmus Soegaard Hansen; Knud Pedersen; Tunde Peto; Jakob Grauslund
Tags: diabetes mellitus, type 2, fractals, nerve degeneration
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7438-7443. doi:https://doi.org/10.1167/iovs.15-17449
The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling Free
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Scott M. Taylor; Karen Alvarez-Delfin; Carole J. Saade; Jennifer L. Thomas; Ryan Thummel; James M. Fadool; Peter F. Hitchcock
Tags: cell cycle, photoreceptors, signal transduction, retina, basic helix-loop-helix transcription factors
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7496-7515. doi:https://doi.org/10.1167/iovs.15-17616
The Time Course of Changes in Retinal Vessel Diameter in Response to Differing Durations of Flicker Light Provocation Free
PDF
Rebekka Heitmar; Robert J. Summers
Tags: diameter, dilatation, pathologic, photopsia, retinal vessels, time factors
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7581-7588. doi:https://doi.org/10.1167/iovs.15-17089

Retinal Cell Biology

Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue Free
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Timothy A. Blenkinsop; Janmeet S. Saini; Arvydas Maminishkis; Kapil Bharti; Qin Wan; Tina Banzon; Mostafa Lotfi; Janine Davis; Deepti Singh; Lawrence J. Rizzolo; Sheldon Miller; Sally Temple; Jeffrey H. Stern
Tags: adult, body tissue, epithelial stem cells, physiology, pigment
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7085-7099. doi:https://doi.org/10.1167/iovs.14-16246
Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice Free
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Takeshi Mizutani; Benjamin J. Fowler; Younghee Kim; Reo Yasuma; Laura A. Krueger; Bradley D. Gelfand; Jayakrishna Ambati
Tags: choroidal neovascularization, lasers, mice, nucleoside reverse transcriptase inhibitors, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7122-7129. doi:https://doi.org/10.1167/iovs.15-17440
N-Ethylmaleimide–Sensitive Factor b (nsfb) Is Required for Normal Pigmentation of the Zebrafish Retinal Pigment Epithelium Free
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Nicholas J. Hanovice; Christina M. S. Daly; Jeffrey M. Gross
Tags: complement factor b, ethylmaleimide, melanosomes, pigmentation, retinal pigment epithelium
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7535-7544. doi:https://doi.org/10.1167/iovs.15-17704

Visual Neuroscience

Cerebral Involvement in Stargardt's Disease: A VBM and TBSS Study Free
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Gaia Olivo; Paolo Melillo; Sirio Cocozza; Francesco Maria D'Alterio; Anna Prinster; Francesco Testa; Arturo Brunetti; Francesca Simonelli; Mario Quarantelli
Tags: atrophy, brain, diagnostic imaging, stargardt's disease, volume
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7388-7397. doi:https://doi.org/10.1167/iovs.15-16899
Visual Pathways in Humans With Ephrin-B1 Deficiency Associated With the Cranio-Fronto-Nasal Syndrome Free
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Michael B. Hoffmann; Hagen Thieme; Karin Liedecke; Synke Meltendorf; Martin Zenker; Ilse Wieland
Tags: ephrins, evoked potentials, visual, syndrome, visual pathways, nose
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7427-7437. doi:https://doi.org/10.1167/iovs.15-17705
Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration Free
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Henri Lorach; Xin Lei; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Roopa Dalal; Philip Huie; James Harris; Daniel Palanker
Tags: prostheses, retinal degeneration, vision, implantation procedure, implants
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7444-7450. doi:https://doi.org/10.1167/iovs.15-17521

Visual Psychophysics and Physiological Optics

Distribution of the Crystalline Lens Power In Vivo as a Function of Age Free
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Sien Jongenelen; Jos J. Rozema; Marie-José Tassignon; on behalf of the EVICR.net and Project Gullstrand Study Group
Tags: lens (device), lens, crystalline, biometry
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7029-7035. doi:https://doi.org/10.1167/iovs.15-18047
Optimal Combination of the Binocular Cues to 3D Motion Free
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Brian Allen; Andrew M. Haun; Taylor Hanley; C. Shawn Green; Bas Rokers
Tags: cues, motion, health disparity
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7589-7596. doi:https://doi.org/10.1167/iovs.15-17696

Letters to the Editor

Use of Clopidogrel and Poor Visual Outcome Free
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Jae Hui Kim
Tags: clopidogrel
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7051. doi:https://doi.org/10.1167/iovs.15-18111
Author Response: Use of Clopidogrel and Poor Visual Outcome Free
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Jesse J. Jung; Bora Chae; Anna C. S. Tan; Samir N. Patel; K. Bailey Freund
Tags: clopidogrel
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7052. doi:https://doi.org/10.1167/iovs.15-18289

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science November 2015, Vol.56, 7084. doi:https://doi.org/10.1167/iovs.15-17276a
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