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Research Highlight

Squiggly Lines and Wiggly Data Free
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Ted Maddess
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7806. doi:https://doi.org/10.1167/iovs.15-18610
Foveal Morphology and the Macular Carotenoids Free
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Billy Randall Hammond
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7866. doi:https://doi.org/10.1167/iovs.15-18407
Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation Free
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Victor L. Perez
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8361. doi:https://doi.org/10.1167/iovs.15-18525
Photoreceptor Mitochondrial Reserve Capacity: Is It the Etiology for Differential Compartmental Vulnerability? Free
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Donald A. Fox; Elda M. Rueda
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8437. doi:https://doi.org/10.1167/iovs.15-18662

Anatomy and Pathology/Oncology

Ciliary Muscle Cell Changes During Guinea Pig Development Free
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Andrew D. Pucker; Ashley R. Jackson; Hugh J. Morris; Andrew J. Fischer; Kirk M. McHugh; Donald O. Mutti
Tags: ciliary muscle, guinea
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7691-7696. doi:https://doi.org/10.1167/iovs.15-17927

Biochemistry and Molecular Biology

Arrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina Free
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Janise D. Deming; Joseph S. Pak; Jung-a Shin; Bruce M. Brown; Moon K. Kim; Moe H. Aung; Eun-Jin Lee; Machelle T. Pardue; Cheryl Mae Craft
Tags: arrestin, electroretinography, mice, opsin, retina
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7618-7628. doi:https://doi.org/10.1167/iovs.15-17832
Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration Free
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Constantin C. Paun; Lebriz Ersoy; Tina Schick; Joannes M. M. Groenewoud; Yara T. Lechanteur; Sascha Fauser; Carel B. Hoyng; Eiko K. de Jong; Anneke I. den Hollander
Tags: age-related macular degeneration, complement activation, genetics, high density lipoprotein cholesterol, lipids
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7766-7773. doi:https://doi.org/10.1167/iovs.15-17035
Tear Production After Bilateral Main Lacrimal Gland Resection in Rabbits Free
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Dhruva Bhattacharya; Yuan Ning; Fangkun Zhao; William Stevenson; Rongji Chen; Jinsong Zhang; Mingwu Wang
Tags: conjunctiva, lacrimal gland, oryctolagus cuniculus, tear production, conjunctival epithelium
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7774-7783. doi:https://doi.org/10.1167/iovs.15-17550
Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina Free
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Ana I. Arroba; Ángela M. Valverde
Tags: cytokine, gliosis, inflammation, insulin-like growth factor i, insulin-like-growth factor i receptor
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8031-8044. doi:https://doi.org/10.1167/iovs.15-17234
The Effect of Ambient Ozone on Unsaturated Tear Film Wax Esters Free
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Riku O. Paananen; Antti H. Rantamäki; Jevgeni Parshintsev; Juha M. Holopainen
Tags: esters, ozone, tear film finding, whole exome sequencing, water
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8054-8062. doi:https://doi.org/10.1167/iovs.15-18398
Cyclic Adenosine Monophosphate Activates Retinal Apolipoprotein A1 Expression and Inhibits Myopic Eye Growth Free
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Rachel Ka Man Chun; Sze Wan Shan; Thomas Chuen Lam; Chun Lung Wong; King Kit Li; Chi Wai Do; Chi Ho To
Tags: cyclic amp, eye, lens (device), apolipoprotein a-i, lens, crystalline
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8151-8157. doi:https://doi.org/10.1167/iovs.14-14233
Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression Free
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Guoxu Xu; Daohuan Kang; Chaoyang Zhang; Hui Lou; Chen Sun; Qian Yang; Lixia Lu; Guo-Tong Xu; Jingfa Zhang; Fang Wang
Tags: diabetes mellitus, erythropoietin, retina, zinc, rats
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8166-8178. doi:https://doi.org/10.1167/iovs.15-18093
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes Free
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Ahmed M. Abu El-Asrar; Kaiser Alam; Mohd Imtiaz Nawaz; Ghulam Mohammad; Kathleen Van den Eynde; Mohammad Mairaj Siddiquei; Ahmed Mousa; Gert De Hertogh; Karel Geboes; Ghislain Opdenakker
Tags: endothelial cells, leukocytes, proliferative diabetic retinopathy, vitreous body, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8239-8247. doi:https://doi.org/10.1167/iovs.15-18025
Exome Sequencing on 298 Probands With Early-Onset High Myopia: Approximately One-Fourth Show Potential Pathogenic Mutations in RetNet Genes Free
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Wenmin Sun; Li Huang; Yan Xu; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Bei Gao; Panfeng Wang; Xiangming Guo; Qingjiong Zhang
Tags: genes, mutation, myopia, proband, whole exome sequencing
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8365-8372. doi:https://doi.org/10.1167/iovs.15-17555
Modulating the Transport Characteristics of Bruch's Membrane With Steroidal Glycosides and its Relevance to Age-Related Macular Degeneration (AMD) Free
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Yunhee Lee; Ali A. Hussain; Jae-Hwan Seok; Suhn-Hee Kim; John Marshall
Tags: biological transport, bruch's basal membrane, panax, lipids, glycosides
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8403-8418. doi:https://doi.org/10.1167/iovs.15-16936
MicroRNA-483-3p Inhibits Extracellular Matrix Production by Targeting Smad4 in Human Trabecular Meshwork Cells Free
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Wencui Shen; Yating Han; Bingqing Huang; Yan Qi; Linqi Xu; Ruru Guo; Xi Wang; Jiantao Wang
Tags: extracellular matrix, micrornas, oxidative stress, smad4 gene, trabecular meshwork
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8419-8427. doi:https://doi.org/10.1167/iovs.15-18036
Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria Free
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Keshav Kooragayala; Norimoto Gotoh; Tiziana Cogliati; Jacob Nellissery; Talia R. Kaden; Stephanie French; Robert Balaban; Wei Li; Raul Covian; Anand Swaroop
Tags: mitochondria, oxygen consumption, photoreceptors, retina, cytochrome a
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8428-8436. doi:https://doi.org/10.1167/iovs.15-17901

Clinical and Epidemiologic Research

Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study Free
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Kohta Fujiwara; Miho Yasuda; Toshiharu Ninomiya; Jun Hata; Sawako Hashimoto; Takeshi Yoshitomi; Yutaka Kiyohara; Tatsuro Ishibashi
Tags: insulin resistance, raised intraocular pressure, risk factors, intraocular pressure
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7983-7987. doi:https://doi.org/10.1167/iovs.15-16766
Relative Contribution of Risk Factors for Early-Onset Myopia in Young Asian Children Free
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Sharon Yu Lin Chua; M. Kamran Ikram; Chuen Seng Tan; Yung Seng Lee; Yu Ni; Cai Shirong; Peter D. Gluckman; Yap-Seng Chong; Fabian Yap; Tien-Yin Wong; Cheryl S. Ngo; Seang-Mei Saw; for the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study Group
Tags: child, myopia, risk factors, asian, parent
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8101-8107. doi:https://doi.org/10.1167/iovs.15-16577

Cornea

Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation Free
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Rose Yvonne Reins; Hasna Baidouri; Alison Marie McDermott
Tags: corneal epithelial cells, vitamin d, inflammation, ll-37 peptide, antimicrobials
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7715-7727. doi:https://doi.org/10.1167/iovs.15-17768
High Throughput Assay Identifies Glafenine as a Corrector for the Folding Defect in Corneal Dystrophy–Causing Mutants of SLC4A11 Free
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Anthony M. Chiu; Jake J. Mandziuk; Sampath K. Loganathan; Kumari Alka; Joseph R. Casey
Tags: glafenine, hereditary corneal dystrophy, proteins, biotinylation, dimethyl sulfoxide
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7739-7753. doi:https://doi.org/10.1167/iovs.15-17802
Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia Free
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Yunhai Dai; Xiaowen Zhao; Peng Chen; Yang Yu; Ye Wang; Lixin Xie
Tags: cornea, diabetes mellitus, hyperglycemia, mice, nerve injuries
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7754-7765. doi:https://doi.org/10.1167/iovs.15-16513
Effects of Insulin and High Glucose on Human Meibomian Gland Epithelial Cells Free
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Juan Ding; Yang Liu; David A. Sullivan
Tags: glucose, insulin, lipids, meibomian gland, hyperinsulinism
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7814-7820. doi:https://doi.org/10.1167/iovs.15-18049
Corneal Expression of SLURP-1 by Age, Sex, Genetic Strain, and Ocular Surface Health Free
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Sudha Swamynathan; Emili E. Delp; Stephen A. K. Harvey; Chelsea L. Loughner; Leela Raju; Shivalingappa K. Swamynathan
Tags: cornea, genetics, health, mice, wounds and injuries
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7888-7896. doi:https://doi.org/10.1167/iovs.15-18206
A Comparison of Different Corneal Iontophoresis Protocols for Promoting Transepithelial Riboflavin Penetration Free
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Daniel M. Gore; David P. O'Brart; Paul French; Chris Dunsby; Bruce D. Allan
Tags: cornea, iontophoresis, riboflavin, mass or substance concentration per volume, epithelium
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7908-7914. doi:https://doi.org/10.1167/iovs.15-17569
Human Corneal MicroRNA Expression Profile in Fungal Keratitis Free
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Hemadevi Boomiraj; Vidyarani Mohankumar; Prajna Lalitha; Bharanidharan Devarajan
Tags: cornea, fungal keratitis, micrornas
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7939-7946. doi:https://doi.org/10.1167/iovs.15-17619
Changes in Irregular Corneal Astigmatism With Age in Eyes With and Without Cataract Surgery Free
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Ken Hayashi; Sumie Kawahara; Shin-ichi Manabe; Akira Hirata
Tags: astigmatism, cataract surgery, cornea, eye, surgical procedures, operative
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7988-7998. doi:https://doi.org/10.1167/iovs.15-18058
Hyperosmolar Tears Induce Functional and Structural Alterations of Corneal Nerves: Electrophysiological and Anatomical Evidence Toward Neurotoxicity Free
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Harumitsu Hirata; Kamila Mizerska; Carl F. Marfurt; Mark I. Rosenblatt
Tags: cornea, hyperosmolality, hyperosmolar hyperglycemia, mosmol, neurons
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8125-8140. doi:https://doi.org/10.1167/iovs.15-18383
VesselJ: A New Tool for Semiautomatic Measurement of Corneal Neovascularization Free
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Alessandro Rabiolo; Fabio Bignami; Paolo Rama; Giulio Ferrari
Tags: alkalies, burns, cornea, corneal neovascularization, lymphatic vessels
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8199-8206. doi:https://doi.org/10.1167/iovs.15-17098
Effect of Stratification on Surface Properties of Corneal Epithelial Cells Free
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Bernardo Yáñez-Soto; Brian C. Leonard; Vijay Krishna Raghunathan; Nicholas L. Abbott; Christopher J. Murphy
Tags: cell culture techniques, corneal epithelial cells, corneal epithelium, dry eye syndromes, engineering
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8340-8348. doi:https://doi.org/10.1167/iovs.15-17468
Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)–Knockout Mice Free
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Takashi Kojima; Murat Dogru; Osama M. A. Ibrahim; Tais Hitomi Wakamatsu; Masataka Ito; Ayako Igarashi; Takaaki Inaba; Takahiko Shimizu; Takuji Shirasawa; Jun Shimazaki; Kazuo Tsubota
Tags: conjunctiva, mice, oxidative stress, sod1 gene, superoxides
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8382-8391. doi:https://doi.org/10.1167/iovs.15-18295
Lacrimal Gland Inflammation Deregulates Extracellular Matrix Remodeling and Alters Molecular Signature of Epithelial Stem/Progenitor Cells Free
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Takeshi Umazume; William M. Thomas; Sabrina Campbell; Hema Aluri; Suharika Thotakura; Driss Zoukhri; Helen P. Makarenkova
Tags: dacryoadenitis, epithelium, extracellular matrix, inflammation, langer-giedion syndrome
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8392-8402. doi:https://doi.org/10.1167/iovs.15-17477

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

A Single Intravitreal Injection of Ranibizumab Provides No Neuroprotection in a Nonhuman Primate Model of Moderate-to-Severe Nonarteritic Anterior Ischemic Optic Neuropathy Free
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Neil R. Miller; Mary A. Johnson; Theresa Nolan; Yan Guo; Steven L. Bernstein
Tags: eye, intravitreal injections, neuroprotection, nonarteritic anterior ischemic optic neuropathy, primates
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7679-7686. doi:https://doi.org/10.1167/iovs.15-18015

Genetics

Variant c.2262A>C in DOCK9 Leads to Exon Skipping in Keratoconus Family Free
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Justyna A. Karolak; Malgorzata Rydzanicz; Barbara Ginter-Matuszewska; Jose A. Pitarque; Andrea Molinari; Bassem A. Bejjani; Marzena Gajecka
Tags: exons, family, genes, keratoconus, rna splicing
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7687-7690. doi:https://doi.org/10.1167/iovs.15-17538
Investigation of Aberrant Splicing Induced by AIPL1 Variations as a Cause of Leber Congenital Amaurosis Free
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James Bellingham; Alice E. Davidson; Jonathan Aboshiha; Francesca Simonelli; James W. Bainbridge; Michel Michaelides; Jacqueline van der Spuy
Tags: exons, leber's amaurosis, rna splicing, introns, rna
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7784-7793. doi:https://doi.org/10.1167/iovs.15-18092
Mouse Models for the Dissection of CHD7 Functions in Eye Development and the Molecular Basis for Ocular Defects in CHARGE Syndrome Free
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Philip J. Gage; Elizabeth A. Hurd; Donna M. Martin
Tags: charge syndrome, ectoderm, embryo, eye, eye development
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7923-7930. doi:https://doi.org/10.1167/iovs.15-18069
Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families Free
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Simone Kastner; Ina-Janine Thiemann; Gabriele Dekomien; Elisabeth Petrasch-Parwez; Sabrina Schreiber; Denis A. Akkad; Wanda M. Gerding; Sabine Hoffjan; Sezgin Güneş; Selçuk Güneş; Hasan Bagci; Jörg T. Epplen
Tags: body tissue, candidate disease gene, family, mice, retina
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8045-8053. doi:https://doi.org/10.1167/iovs.15-17473
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population Free
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Minming Zheng; Hongsong Yu; Lijun Zhang; Hua Li; Yunjia Liu; Aize Kijlstra; Peizeng Yang
Tags: behcet syndrome, chinese (other dialects), chinese people, genes, polymorphism
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8280-8287. doi:https://doi.org/10.1167/iovs.15-18035
Genotype and Phenotype Studies in Autosomal Dominant Retinitis Pigmentosa (adRP) of the French Canadian Founder Population Free
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Razek Georges Coussa; Christina Chakarova; Radwan Ajlan; Mohammed Taha; Conrad Kavalec; Julius Gomolin; Ayesha Khan; Irma Lopez; Huanan Ren; Naushin Waseem; Kunka Kamenarova; Shomi S. Bhattacharya; Robert K. Koenekoop
Tags: french, genotype, mutation, phenotype, retinitis pigmentosa
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8297-8305. doi:https://doi.org/10.1167/iovs.15-17104

Glaucoma

Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes Free
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Sasan Moghimi; Farshid Ramezani; Mingguang He; Anne L. Coleman; Shan C. Lin
Tags: eye, optics, tomography, immune reconstitution inflammatory syndrome, iris
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7611-7617. doi:https://doi.org/10.1167/iovs.15-17336
The Connective Tissue Components of Optic Nerve Head Cupping in Monkey Experimental Glaucoma Part 1: Global Change Free
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Hongli Yang; Ruojin Ren; Howard Lockwood; Galen Williams; Vincent Libertiaux; Crawford Downs; Stuart K. Gardiner; Claude F. Burgoyne
Tags: cercopithecidae, connective tissue, cupping therapy, eye, glaucoma
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7661-7678. doi:https://doi.org/10.1167/iovs.15-17624
The Ability of 10-2 Short-Wavelength Perimetry in Detecting Functional Loss of the Macular Area in Preperimetric Glaucoma Patients Free
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Younhea Jung; Hae-Young L. Park; Hyun Jin Jeong; Seung Yong Choi; Chan Kee Park
Tags: glaucoma, perimetry, shedler-westen assessment procedure–200
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7708-7714. doi:https://doi.org/10.1167/iovs.15-17819
Optimizing the Detection of Preperimetric Glaucoma by Combining Structural and Functional Tests Free
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Prema Sriram; Alexander Klistorner; Stuart Graham; John Grigg; Hemamalini Arvind
Tags: glaucoma, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7794-7800. doi:https://doi.org/10.1167/iovs.15-16721
Estimating the Usefulness of Humphrey Perimetry Gaze Tracking for Evaluating Structure–Function Relationship in Glaucoma Free
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Yukako Ishiyama; Hiroshi Murata; Hiroyo Hirasawa; Ryo Asaoka
Tags: gaze, glaucoma, perimetry, visual fields
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7801-7805. doi:https://doi.org/10.1167/iovs.15-17988
Lens Position Parameters as Predictors of Intraocular Pressure Reduction After Cataract Surgery in Nonglaucomatous Patients With Open Angles Free
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Chi-Hsin Hsu; Caitlin L. Kakigi; Shuai-Chun Lin; Yuan-Hung Wang; Travis Porco; Shan C. Lin
Tags: cataract surgery, intraocular pressure, lens (device), lens, crystalline, predictive value
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7807-7813. doi:https://doi.org/10.1167/iovs.15-17926
High-Magnitude and/or High-Frequency Mechanical Strain Promotes Peripapillary Scleral Myofibroblast Differentiation Free
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Jing Qu; Huaping Chen; Lanyan Zhu; Namasivayam Ambalavanan; Christopher A. Girkin; Joanne E. Murphy-Ullrich; J. Crawford Downs; Yong Zhou
Tags: fibroblasts, myofibroblasts, proteins, rna, messenger, sclera
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7821-7830. doi:https://doi.org/10.1167/iovs.15-17848
Diagnostic Ability of Retinal Vessel Diameter Measurements in Open-Angle Glaucoma Free
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Eunjoo Yoo; Chungkwon Yoo; Bo-ram Lee; Tae-Eun Lee; Yong Yeon Kim
Tags: diameter, glaucoma, open-angle glaucoma, retinal nerve fiber layer, retinal vessels
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7915-7922. doi:https://doi.org/10.1167/iovs.15-18087
Location of Initial Visual Field Defects in Glaucoma and Their Modes of Deterioration Free
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Joon Mo Kim; Haksu Kyung; Seong Hee Shim; Parham Azarbod; Joseph Caprioli
Tags: glaucoma, nose, scotoma, visual field defects
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7956-7962. doi:https://doi.org/10.1167/iovs.15-17297
MicroRNA Expression in the Glaucomatous Retina Free
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Hari Jayaram; William O. Cepurna; Elaine C. Johnson; John C. Morrison
Tags: glaucoma, micrornas, genes, retina
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7971-7982. doi:https://doi.org/10.1167/iovs.15-18088
Migraine and Vasospasm in Glaucoma: Age-Related Evaluation of 2027 Patients With Glaucoma or Ocular Hypertension Free
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Gwendolyn Gramer; Bernhard H. F. Weber; Eugen Gramer
Tags: glaucoma, migraine disorders, vascular constriction
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7999-8007. doi:https://doi.org/10.1167/iovs.15-17274
Altered Transport Velocity of Axonal Mitochondria in Retinal Ganglion Cells After Laser-Induced Axonal Injury In Vitro Free
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Satoshi Yokota; Yuji Takihara; Shogo Arimura; Seiji Miyake; Yoshihiro Takamura; Nagahisa Yoshimura; Masaru Inatani
Tags: lasers, mitochondria, mitochondrial transport, velocity, wounds and injuries
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8019-8025. doi:https://doi.org/10.1167/iovs.15-17876
Comparing the Structure–Function Relationship at the Macula With Standard Automated Perimetry and Microperimetry Free
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Harsha L. Rao; Manideepak Januwada; Raza S. M. Hussain; Lalitha N. Pillutla; Viquar U. Begum; Aditya Chaitanya; Sirisha Senthil; Chandra S. Garudadri
Tags: glaucoma, macula densa, macula lutea, perimetry
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8063-8068. doi:https://doi.org/10.1167/iovs.15-17922
Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport Free
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David Kleesattel; Samuel D. Crish; Denise M. Inman
Tags: axon, biological transport, fatigue, mitochondria, optic nerve
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8215-8227. doi:https://doi.org/10.1167/iovs.15-17885
Glaucoma Detection Ability of Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Preperimetric Glaucoma Free
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Bo Ram Seol; Jin Wook Jeoung; Ki Ho Park
Tags: ganglia, glaucoma, optic disk, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8306-8313. doi:https://doi.org/10.1167/iovs.15-18141
Physical Factors Affecting Outflow Facility Measurements in Mice Free
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Alexandra Boussommier-Calleja; Guorong Li; Amanda Wilson; Tal Ziskind; Oana Elena Scinteie; Nicole E. Ashpole; Joseph M. Sherwood; Sina Farsiu; Pratap Challa; Pedro Gonzalez; J. Crawford Downs; C. Ross Ethier; W. Daniel Stamer; Darryl R. Overby
Tags: eye, mice, perfusion, immune reconstitution inflammatory syndrome, body temperature
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8331-8339. doi:https://doi.org/10.1167/iovs.15-17106

Immunology and Microbiology

Elevated S100A8/A9 and S100A12 Serum Levels Reflect Intraocular Inflammation in Juvenile Idiopathic Arthritis-Associated Uveitis: Results From a Pilot Study Free
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Karoline Walscheid; Arnd Heiligenhaus; Dirk Holzinger; Johannes Roth; Carsten Heinz; Christoph Tappeiner; Maren Kasper; Dirk Foell
Tags: arthritis, s100a12 protein, uveitis, uveitis, anterior, s100 proteins
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7653-7660. doi:https://doi.org/10.1167/iovs.15-17066
A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1β and Inhibition of PGE2 Free
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Qian Shi; Qiu Wang; Jing Li; Xiaohui Zhou; Huimin Fan; Fenghua Wang; Haiyun Liu; Xiangjun Sun; Xiaodong Sun
Tags: dinoprostone, retinal pigment cell, th1 cells, t-lymphocytes
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7728-7738. doi:https://doi.org/10.1167/iovs.15-17677
Innate Immune Signaling Induces IL-7 Production, Early Inflammatory Responses, and Sjögren's-Like Dacryoadenitis in C57BL/6 Mice Free
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Jing Zhou; Jun-O, Jin; Juan Du; Qing Yu
Tags: interleukin-7, mice, poly i-c, dacryoadenitis, mice, inbred c57bl
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7831-7838. doi:https://doi.org/10.1167/iovs.15-17368
Thrombomodulin Protects Against Bacterial Keratitis, Is Anti-Inflammatory, but Not Angiogenic Free
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Sharon A. McClellan; Sandamali A. Ekanayaka; Cui Li; Xiaoyu Jiang; Ronald P. Barrett; Linda D. Hazlett
Tags: angiogenesis, anti-inflammatory agents, bacterial keratitis, cornea, infections
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8091-8100. doi:https://doi.org/10.1167/iovs.15-18393
Primed Mycobacterial Uveitis (PMU): Histologic and Cytokine Characterization of a Model of Uveitis in Rats Free
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Kathryn L. Pepple; Lauren Rotkis; Jennifer Van Grol; Leslie Wilson; Angela Sandt; Deborah L. Lam; Eric Carlson; Russell N. Van Gelder
Tags: cytokine, rats, uveitis, inflammation
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8438-8448. doi:https://doi.org/10.1167/iovs.15-17523
Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats Free
PDF
Kathryn L. Pepple; Lauren Rotkis; Leslie Wilson; Angela Sandt; Russell N. Van Gelder
Tags: inflammation, proteins, rats, uveitis, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8449-8456. doi:https://doi.org/10.1167/iovs.15-17524

Lens

Ku80 Counters Oxidative Stress–Induced DNA Damage and Cataract Formation in the Human Lens Free
PDF
Andrew John Oliver Smith; Simon Sidney Robert Ball; Kamal Manzar; Richard Peter Bowater; Ian Michael Wormstone
Tags: cataract, dna damage, lens, crystalline, oxidative stress
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7868-7874. doi:https://doi.org/10.1167/iovs.15-18309
Potential Modifying Loci Associated With Primary Lens Luxation, Pedal Hyperkeratosis, and Ocular Phenotypes in Miniature Bull Terriers Free
PDF
Puya Gharahkhani; Caroline A. O'Leary; David L. Duffy; Myat Kyaw-Tanner
Tags: dog, domestic, foot, keratosis, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8288-8296. doi:https://doi.org/10.1167/iovs.15-18074
Proteomic Analysis of Lipid Raft-Like Detergent-Resistant Membranes of Lens Fiber Cells Free
PDF
Zhen Wang; Kevin L. Schey
Tags: cholesterol, desmin-related myopathy, detergents, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8349-8360. doi:https://doi.org/10.1167/iovs.15-18273

Physiology and Pharmacology

Subconjunctivally Implanted Hydrogels for Sustained Insulin Release to Reduce Retinal Cell Apoptosis in Diabetic Rats Free
PDF
Hisanori Imai; Gauri P. Misra; Linfeng Wu; Dileep R. Janagam; Thomas W. Gardner; Tao L. Lowe
Tags: hydrogels, insulin, diabetes mellitus, rats
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7839-7846. doi:https://doi.org/10.1167/iovs.15-16998
Bevacizumab and Aflibercept Activate Platelets via FcγRIIa Free
PDF
Yoko Nomura; Makoto Kaneko; Kanjiro Miyata; Yutaka Yatomi; Yasuo Yanagi
Tags: aflibercept, bevacizumab, blood platelets, platelet aggregation, ranibizumab
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8075-8082. doi:https://doi.org/10.1167/iovs.15-17814
Ocular Safety of Intravitreal Propranolol and Its Efficacy in Attenuation of Choroidal Neovascularization Free
PDF
Ramin Nourinia; Mozhgan Rezaei Kanavi; Amir Kaharkaboudi; Seyed Iman Taghavi; Seyed Javid Aldavood; Soesiawati R. Darjatmoko; Shoujian Wang; Zafer Gurel; Jeremy A. Lavine; Sare Safi; Hamid Ahmadieh; Narsis Daftarian; Nader Sheibani
Tags: choroidal neovascularization, propranolol, safety, oryctolagus cuniculus, electroretinography
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8228-8235. doi:https://doi.org/10.1167/iovs.15-17169

Retina

Electrophysiological ON and OFF Responses in Autosomal Dominant Optic Atrophy Free
PDF
Enyam Komla A. Morny; Tom H. Margrain; Alison M. Binns; Marcela Votruba
Tags: electroretinography, erg protein, human, optic atrophy, autosomal dominant
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7629-7637. doi:https://doi.org/10.1167/iovs.15-17951
Optical Coherence Tomography Angiography of a Choroidal Neovascularization in Adult Onset Foveomacular Vitelliform Dystrophy: Pearls and Pitfalls Free
PDF
Marco Lupidi; Gabriel Coscas; Carlo Cagini; Florence Coscas
Tags: angiogram, choroidal neovascularization, diagnostic imaging, optical coherence tomography, vitelliform dystrophy
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7638-7645. doi:https://doi.org/10.1167/iovs.15-17603
The Spatial Profile of Macular Pigments Is Related to the Topological Characteristics of the Foveal Avascular Zone Free
PDF
Chandrakumar Balaratnasingam; Bora Chae; Meredith H. Remmer; Erasmo Gomez; Mihoko Suzuki; Michael Engelbert; Richard F. Spaide
Tags: macular pigment, pigment
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7859-7865. doi:https://doi.org/10.1167/iovs.15-17532
Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy With Severe Photoreceptor and Ganglion Cell Loss Free
PDF
Lucas Bonafede; Can H. Ficicioglu; Leona Serrano; Grace Han; Jessica I. W. Morgan; Monte D. Mills; Brian J. Forbes; Stefanie L. Davidson; Gil Binenbaum; Paige B. Kaplan; Charles W. Nichols; Patrick Verloo; Bart P. Leroy; Albert M. Maguire; Tomas S. Aleman
Tags: cobalamin, ganglia, macular disorders, photoreceptors, retina
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7875-7887. doi:https://doi.org/10.1167/iovs.15-17857
Oral Lutein Supplementation Enhances Macular Pigment Density and Contrast Sensitivity but Not in Combination With Polyunsaturated Fatty Acids Free
PDF
Ute E. K. Wolf-Schnurrbusch; Martin S. Zinkernagel; Marion R. Munk; Andreas Ebneter; Sebastian Wolf
Tags: contrast sensitivity, lutein, macular pigment, polyunsaturated fatty acids
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8069-8074. doi:https://doi.org/10.1167/iovs.15-17586
Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene Free
PDF
Panagiotis I. Sergouniotis; Martin McKibbin; Anthony G. Robson; Hanno J. Bolz; Elfride De Baere; Philipp L. Müller; Raoul Heller; Mohammed E. El-Asrag; Kristof Van Schil; Vincent Plagnol; Carmel Toomes; UK Inherited Retinal Disease Consortium; Manir Ali; Graham E. Holder; Peter Charbel Issa; Bart P. Leroy; Chris F. Inglehearn; Andrew R. Webster
Tags: autosomal recessive inheritance, genes, mutation, retinal diseases, retinal dystrophies
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8083-8090. doi:https://doi.org/10.1167/iovs.15-17604
En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy Free
PDF
Elisabetta Pilotto; Francesca Guidolin; Enrica Convento; Rachele Antonini; Francesco Giuseppe Stefanon; Raffaele Parrozzani; Edoardo Midena
Tags: atrophy, face, optical coherence tomography
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8120-8124. doi:https://doi.org/10.1167/iovs.15-17366
A Novel BEST1 Mutation in Autosomal Recessive Bestrophinopathy Free
PDF
Christopher Seungkyu Lee; Ikhyun Jun; Seung-il Choi; Ji Hwan Lee; Min Goo Lee; Sung Chul Lee; Eung Kweon Kim
Tags: autosomal recessive inheritance, mutation
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8141-8150. doi:https://doi.org/10.1167/iovs.15-18168
Choroideremia Is a Systemic Disease With Lymphocyte Crystals and Plasma Lipid and RBC Membrane Abnormalities Free
PDF
Alice Yang Zhang; Naveen Mysore; Hojatollah Vali; Jamie Koenekoop; Sang Ni Cao; Shen Li; Huanan Ren; Vafa Keser; Irma Lopez-Solache; Sorath Noorani Siddiqui; Ayesha Khan; Jeannie Mui; Kelly Sears; Jim Dixon; Jeremy Schwartzentruber; Jacek Majewski; Nancy Braverman; Robert K. Koenekoop
Tags: choroideremia, fatty acids, lipids, lymphocytes, plasma
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8158-8165. doi:https://doi.org/10.1167/iovs.14-15751
Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study Free
PDF
Philipp L. Müller; Martin Gliem; Elisabeth Mangold; Hanno J. Bolz; Robert P. Finger; Myra McGuinness; Christian Betz; Zhichun Jiang; Bernhard H. F. Weber; Robert E. MacLaren; Frank G. Holz; Roxana A. Radu; Peter Charbel Issa
Tags: autofluorescence, mutation, phenotype, retinal diseases, mice
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8179-8186. doi:https://doi.org/10.1167/iovs.15-17629
Concordance of Macular Pigment Measurement Using Customized Heterochromatic Flicker Photometry and Fundus Autofluorescence in Age-Related Macular Degeneration Free
PDF
Kwadwo Owusu Akuffo; Stephen Beatty; Jim Stack; Tunde Peto; Irene Leung; Laura Corcoran; Rebecca Power; John M. Nolan
Tags: age-related macular degeneration, cataract, photometry, photopsia, carotenoids
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8207-8214. doi:https://doi.org/10.1167/iovs.15-17822
Light-Regulated Thyroid Hormone Signaling Is Required for Rod Photoreceptor Development in the Mouse Retina Free
PDF
Onkar Sawant; Amanda M. Horton; Meenal Shukla; Mary E. Rayborn; Neal S. Peachey; Joe G. Hollyfield; Sujata Rao
Tags: mice, retina, rhodopsin, rod photoreceptors, signal transduction
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8248-8257. doi:https://doi.org/10.1167/iovs.15-17743
Wnt/β-Catenin Signaling Mediates Regeneration of Retinal Pigment Epithelium After Laser Photocoagulation in Mouse Eye Free
PDF
Jung Woo Han; Jungmook Lyu; Yeo jin Park; Sun Young Jang; Tae Kwann Park
Tags: lasers, light coagulation, mice, signal transduction, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8314-8324. doi:https://doi.org/10.1167/iovs.15-18359
Predictive Value of Outer Retina En Face OCT Imaging for Geographic Atrophy Progression Free
PDF
Audrey Giocanti-Auregan; Ramin Tadayoni; Franck Fajnkuchen; Pauline Dourmad; Stéphanie Magazzeni; Salomon Y. Cohen
Tags: atrophy, diagnostic imaging, face, predictive value, retina
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8325-8330. doi:https://doi.org/10.1167/iovs.14-15480
The Dorsal Raphe Nucleus Receives Afferents From Alpha-Like Retinal Ganglion Cells and Intrinsically Photosensitive Retinal Ganglion Cells in the Rat Free
PDF
Xiaotao Li; Chaoran Ren; Lu Huang; Bin Lin; Mingliang Pu; Gary E. Pickard; Kwok-Fai So
Tags: dorsal raphe nucleus, retinal ganglion cells, rats, injections, melanopsin
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8373-8381. doi:https://doi.org/10.1167/iovs.15-16614

Retinal Cell Biology

LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury Free
PDF
Weiwei Wang; Ellen Townes-Anderson
Tags: lim domain kinase 1, rod photoreceptors, wounds and injuries, retinal detachment
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7847-7858. doi:https://doi.org/10.1167/iovs.15-17278
Measuring In Vivo Free Radical Production by the Outer Retina Free
PDF
Bruce A. Berkowitz; Bryce X. Bredell; Christopher Davis; Marijana Samardzija; Christian Grimm; Robin Roberts
Tags: free radicals, magnetic resonance imaging, oxidative stress, retina, iodates
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7931-7938. doi:https://doi.org/10.1167/iovs.15-18420
Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa Free
PDF
Tami H. Bogéa; Runxia H. Wen; Orson L. Moritz
Tags: animals, transgenic, autophagy, retinal degeneration, retinitis pigmentosa, rhodopsin
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7947-7955. doi:https://doi.org/10.1167/iovs.15-16799
Abnormal Glycogen Storage by Retinal Neurons in Diabetes Free
PDF
Tom A. Gardiner; Paul Canning; Nuala Tipping; Desmond B. Archer; Alan W. Stitt
Tags: diabetes mellitus, glycogen, neurons, retina, phosphatidylglycerols
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8008-8018. doi:https://doi.org/10.1167/iovs.15-18441
Adenosine A1 Receptors Selectively Modulate Oxygen-Induced Retinopathy at the Hyperoxic and Hypoxic Phases by Distinct Cellular Mechanisms Free
PDF
Shuya Zhang; Haiyan Li; Bo Li; Dingjuan Zhong; Xuejiao Gu; Lingyun Tang; Yanyan Wang; Cun Wang; Rong Zhou; Yan Li; Yan He; Mozi Chen; Yuqing Huo; Xiao-Ling Liu; Jiang-Fan Chen
Tags: adenosine, genetics, hypoxia, mice, oxygen
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8108-8119. doi:https://doi.org/10.1167/iovs.15-17202
Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function Free
PDF
Dibyendu Chakraborty; Shannon M. Conley; Marci L. DeRamus; Steven J. Pittler; Muna I. Naash
Tags: protein overexpression, proteins, retina, retinal cone, rod photoreceptors
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8187-8198. doi:https://doi.org/10.1167/iovs.15-17785
Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration Free
PDF
Allison E. Songstad; Luke A. Wiley; Khahn Duong; Emily Kaalberg; Miles J. Flamme-Wiese; Cathryn M. Cranston; Megan J. Riker; Dana Levasseur; Edwin M. Stone; Robert F. Mullins; Budd A. Tucker
Tags: age-related macular degeneration, chronic exertional compartment syndrome, endothelial cells, mice, chloramphenicol o-acetyltransferase
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8258-8267. doi:https://doi.org/10.1167/iovs.15-17073
Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats Free
PDF
Lin-Song Qi; Lu Yao; Wei Liu; Wei-Xun Duan; Bin Wang; Lei Zhang; Zuo-Ming Zhang
Tags: hepatorenal syndrome, hrs trial, hydrogen, light exposure, normal saline
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8268-8279. doi:https://doi.org/10.1167/iovs.15-17034

Visual Neuroscience

Impact of CB1 Receptor Deletion on Visual Responses and Organization of Primary Visual Cortex in Adult Mice Free
PDF
Reza Abbas Farishta; Céline Robert; Olivier Turcot; Sébastien Thomas; Matthieu P. Vanni; Jean-François Bouchard; Christian Casanova
Tags: mice, primary visual cortex, spatial frequency, visual cortex, contrast sensitivity
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7697-7707. doi:https://doi.org/10.1167/iovs.15-17690
BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy Free
PDF
José Carlos Rivera; Baraa Noueihed; Samy Omri; Jose Barrueco; Frank Hilberg; Sylvain Chemtob
Tags: neovascularization, pathologic, nintedanib, retinal neovascularization
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7897-7907. doi:https://doi.org/10.1167/iovs.15-17146

Visual Psychophysics and Physiological Optics

Macular Choroidal Thickness in Children: The Shandong Children Eye Study Free
PDF
Juan Mei Zhang; Jian Feng Wu; Jian Hua Chen; Ling Wang; Tai Liang Lu; Wei Sun; Yuan Yuan Hu; Wen Jun Jiang; Da Dong Guo; Xing Rong Wang; Hong Sheng Bi; Jost B. Jonas
Tags: child, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7646-7652. doi:https://doi.org/10.1167/iovs.15-17137

Clinical Trials

A Novel Dual Agonist of EP3 and FP Receptors for OAG and OHT: Safety, Pharmacokinetics, and Pharmacodynamics of ONO-9054 in Healthy Volunteers Free
PDF
Fumitaka Suto; Cheryl L. Rowe-Rendleman; Takafumi Ouchi; Alam Jamil; Andrew Wood; Caroline L. Ward
Tags: agonists, pharmacodynamics, pharmacokinetics, placebos, safety
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7963-7970. doi:https://doi.org/10.1167/iovs.15-18166

Letters to the Editor

Dimensional and Flow Properties of the EX-PRESS Glaucoma Drainage Device Free
PDF
Richard M. H. Lee; Amir Samsudin; Yann Bouremel; Steve Brocchini; Peng Tee Khaw
Tags: fluid flow, glaucoma drainage implants
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8026. doi:https://doi.org/10.1167/iovs.15-18495
Author Response: Dimensional and Flow Properties of the EX-PRESS Glaucoma Drainage Device Free
PDF
Arsham Sheybani; Iqbal Ike K. Arsham
Tags: fluid flow, glaucoma drainage implants
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8027. doi:https://doi.org/10.1167/iovs.15-18623
Further Consideration of the Association Between OR2W3 Mutation and Retinitis Pigmentosa Free
PDF
Di Zhang; Xiaobo Huang
Tags: mutation, retinitis pigmentosa
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8028. doi:https://doi.org/10.1167/iovs.15-18142
Helicobacter pylori–Related Impact on Glaucoma Pathophysiology Free
PDF
Jannis Kountouras; Christos Zavos; Christos Zeglinas; Stergios A. Polyzos; Panagiotis Katsinelos
Tags: glaucoma, helicobacter pylori, pathophysiology
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8029-8030. doi:https://doi.org/10.1167/iovs.15-17969
IL-18 Immunotherapy for Neovascular AMD Free
PDF
Zhengwei Zhang
Tags: exudative age-related macular degeneration, immunotherapy, interleukin-18
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8236. doi:https://doi.org/10.1167/iovs.15-18616
Author Response: The Role of IL-18 in the Treatment of AMD Free
PDF
Sarah L. Doyle; Francisco J. López; Peter Humphries; Peter Adamson; Matthew Campbell
Tags: interleukin-18
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8237-8238. doi:https://doi.org/10.1167/iovs.15-18714
Tailoring Myopic CNV Treatment Based on Preexisting Ophthalmic Condition Free
PDF
Tianwei Ellen Zhou; Vikrant K. Bhosle; Sylvain Chemtob
Tags: choroidal neovascularization, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8362-8363. doi:https://doi.org/10.1167/iovs.15-18314
Choroidal Response to Anti-VEGF Therapy in Subgroups Classified by Preexisting Ophthalmic or Systemic Condition Free
PDF
Seong Joon Ahn; Kyu Hyung Park; Se Joon Woo
Tags: anti-vascular endothelial growth factor therapy, eye
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 8364. doi:https://doi.org/10.1167/iovs.15-18634

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science December 2015, Vol.56, 7867. doi:https://doi.org/10.1167/iovs.15-16899a
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