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Research Highlight

Distribution of Palisade Endings Across Species Suggests They Function in Vergence Eye Movement Control Open Access
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Martin J. Steinbach
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 948. doi:10.1167/iovs.16-19151
The Evaporation Barrier of the Tear Film Lipid Layer Open Access
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P. Ewen King-Smith
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 959. doi:10.1167/iovs.16-19161
A New Alternative to Riboflavin/Ultraviolet-A: Collagen Cross-Linking With Rose Bengal/Green Light Open Access
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Koray Gumus
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1002. doi:10.1167/iovs.16-19319

Biochemistry and Molecular Biology

Notch Signaling in Meibomian Gland Epithelial Cell Differentiation Open Access
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Sanaz Gidfar; Neda Afsharkhamseh; Sara Sanjari; Ali R. Djalilian
Tags: epithelial cells, lipids, meibomian gland, notch1 gene, signal transduction
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 859-865. doi:10.1167/iovs.15-18319
Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality Open Access
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Murali Subramani; Ponnalagu Murugeswari; Kamesh Dhamodaran; Priyanka Chevour; Sindhu Gunasekaran; Rajesh S. Kumar; Chaitra Jayadev; Rohit Shetty; Nargis Begum; Debashish Das
Tags: bevacizumab, did not receive therapy or drug, epithelium, mass or substance concentration per volume, phagocytosis
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1140-1152. doi:10.1167/iovs.15-18330
The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction Open Access
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William P. Miller; Maria L. Mihailescu; Chen Yang; Alistair J. Barber; Scot R. Kimball; Leonard S. Jefferson; Michael D. Dennis
Tags: catabolism, diabetes mellitus, hyperglycemia, plague, proteins
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1327-1337. doi:10.1167/iovs.15-18719

Clinical and Epidemiologic Research

Association Between Starting Hemodialysis for End-Stage Renal Disease and Incident Cataract Surgery: A 12-Year Nationwide Cohort Study Open Access
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Tyler Hyungtaek Rim; Chang-Yun Yoon; Hye Won Park; Eun Jee Chung
Tags: cataract surgery, cohort studies, hemodialysis, kidney failure, chronic
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1112-1119. doi:10.1167/iovs.15-18276
Prevalence of Age-Related Cataract and Cataract Surgery in a Chinese Adult Population: The Taizhou Eye Study Open Access
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Yating Tang; Xiaofeng Wang; Jiucun Wang; Wei Huang; Yaping Gao; Yi Luo; Jin Yang; Yi Lu
Tags: adult, cataract, cataract surgery, cataract, senile, chinese people
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1193-1200. doi:10.1167/iovs.15-18380

Cornea

Early Corneal Cellular and Nerve Fiber Pathology in Young Patients With Type 1 Diabetes Mellitus Identified Using Corneal Confocal Microscopy Open Access
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Eszter Szalai; Eszter Deák; László Módis, Jr; Gábor Németh; András Berta; Annamária Nagy; Enikő Felszeghy; Rita Káposzta; Rayaz A. Malik; Adrienne Csutak
Tags: cornea, diabetes mellitus, type 1, microscopy, confocal, nerve fibers, pathology
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 853-858. doi:10.1167/iovs.15-18735
Relationship of Corneal Pain Sensitivity With Dry Eye Symptoms in Dry Eye With Short Tear Break-Up Time Open Access
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Minako Kaido; Motoko Kawashima; Reiko Ishida; Kazuo Tsubota
Tags: cornea, dry eye syndromes, pain, pain threshold, signs and symptoms
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 914-919. doi:10.1167/iovs.15-18447
Short-Term Ultraviolet A Irradiation Leads to Dysfunction of the Limbal Niche Cells and an Antilymphangiogenic and Anti-inflammatory Micromilieu Open Access
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Maria Notara; Nasrin Refaian; Gabriele Braun; Philipp Steven; Felix Bock; Claus Cursiefen
Tags: anti-inflammatory agents, epithelial cells, fibroblasts, pathophysiology, ultraviolet a radiation
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 928-939. doi:10.1167/iovs.15-18343
Instability and Breakup of Model Tear Films Open Access
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M. Saad Bhamla; Chew Chai; Noelle I. Rabiah; John M. Frostad; Gerald G. Fuller
Tags: lens (device), lens, crystalline, lipids, painful bladder syndrome, tear film finding
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 949-958. doi:10.1167/iovs.15-18064
The Ocular Surface in Medically Controlled Glaucoma: An In Vivo Confocal Study Open Access
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Edoardo Villani; Matteo Sacchi; Fabrizio Magnani; Angelo Nicodemo; Susan E. I. Williams; Alessandro Rossi; Roberto Ratiglia; Stefano De Cillà; Paolo Nucci
Tags: conjunctiva, dendritic cells, glaucoma, neurons
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1003-1010. doi:10.1167/iovs.15-17455
AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development Open Access
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Lisheng Chen; Vanessa Martino; Alan Dombkowski; Trevor Williams; Judith West-Mays; Philip J. Gage
Tags: