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Research Highlight

Distribution of Palisade Endings Across Species Suggests They Function in Vergence Eye Movement Control Open Access
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Martin J. Steinbach
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 948. doi:https://doi.org/10.1167/iovs.16-19151
The Evaporation Barrier of the Tear Film Lipid Layer Open Access
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P. Ewen King-Smith
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 959. doi:https://doi.org/10.1167/iovs.16-19161
A New Alternative to Riboflavin/Ultraviolet-A: Collagen Cross-Linking With Rose Bengal/Green Light Open Access
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Koray Gumus
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1002. doi:https://doi.org/10.1167/iovs.16-19319

Biochemistry and Molecular Biology

Notch Signaling in Meibomian Gland Epithelial Cell Differentiation Open Access
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Sanaz Gidfar; Neda Afsharkhamseh; Sara Sanjari; Ali R. Djalilian
Tags: epithelial cells, lipids, meibomian gland, notch1 gene, signal transduction
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 859-865. doi:https://doi.org/10.1167/iovs.15-18319
Short Pulse of Clinical Concentration of Bevacizumab Modulates Human Retinal Pigment Epithelial Functionality Open Access
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Murali Subramani; Ponnalagu Murugeswari; Kamesh Dhamodaran; Priyanka Chevour; Sindhu Gunasekaran; Rajesh S. Kumar; Chaitra Jayadev; Rohit Shetty; Nargis Begum; Debashish Das
Tags: bevacizumab, did not receive therapy or drug, epithelium, mass or substance concentration per volume, phagocytosis
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1140-1152. doi:https://doi.org/10.1167/iovs.15-18330
The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction Open Access
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William P. Miller; Maria L. Mihailescu; Chen Yang; Alistair J. Barber; Scot R. Kimball; Leonard S. Jefferson; Michael D. Dennis
Tags: catabolism, diabetes mellitus, hyperglycemia, plague, proteins
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1327-1337. doi:https://doi.org/10.1167/iovs.15-18719

Clinical and Epidemiologic Research

Association Between Starting Hemodialysis for End-Stage Renal Disease and Incident Cataract Surgery: A 12-Year Nationwide Cohort Study Open Access
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Tyler Hyungtaek Rim; Chang-Yun Yoon; Hye Won Park; Eun Jee Chung
Tags: cataract surgery, cohort studies, hemodialysis, kidney failure, chronic
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1112-1119. doi:https://doi.org/10.1167/iovs.15-18276
Prevalence of Age-Related Cataract and Cataract Surgery in a Chinese Adult Population: The Taizhou Eye Study Open Access
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Yating Tang; Xiaofeng Wang; Jiucun Wang; Wei Huang; Yaping Gao; Yi Luo; Jin Yang; Yi Lu
Tags: adult, cataract, cataract surgery, cataract, senile, chinese people
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1193-1200. doi:https://doi.org/10.1167/iovs.15-18380

Cornea

Early Corneal Cellular and Nerve Fiber Pathology in Young Patients With Type 1 Diabetes Mellitus Identified Using Corneal Confocal Microscopy Open Access
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Eszter Szalai; Eszter Deák; László Módis, Jr; Gábor Németh; András Berta; Annamária Nagy; Enikő Felszeghy; Rita Káposzta; Rayaz A. Malik; Adrienne Csutak
Tags: cornea, diabetes mellitus, type 1, microscopy, confocal, nerve fibers, pathology
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 853-858. doi:https://doi.org/10.1167/iovs.15-18735
Relationship of Corneal Pain Sensitivity With Dry Eye Symptoms in Dry Eye With Short Tear Break-Up Time Open Access
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Minako Kaido; Motoko Kawashima; Reiko Ishida; Kazuo Tsubota
Tags: cornea, dry eye syndromes, pain threshold, signs and symptoms, pain
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 914-919. doi:https://doi.org/10.1167/iovs.15-18447
Short-Term Ultraviolet A Irradiation Leads to Dysfunction of the Limbal Niche Cells and an Antilymphangiogenic and Anti-inflammatory Micromilieu Open Access
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Maria Notara; Nasrin Refaian; Gabriele Braun; Philipp Steven; Felix Bock; Claus Cursiefen
Tags: anti-inflammatory agents, epithelial cells, fibroblasts, ultraviolet a radiation, pathophysiology
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 928-939. doi:https://doi.org/10.1167/iovs.15-18343
Instability and Breakup of Model Tear Films Open Access
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M. Saad Bhamla; Chew Chai; Noelle I. Rabiah; John M. Frostad; Gerald G. Fuller
Tags: lens (device), painful bladder syndrome, tear film finding, lens, crystalline, lipids
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 949-958. doi:https://doi.org/10.1167/iovs.15-18064
The Ocular Surface in Medically Controlled Glaucoma: An In Vivo Confocal Study Open Access
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Edoardo Villani; Matteo Sacchi; Fabrizio Magnani; Angelo Nicodemo; Susan E. I. Williams; Alessandro Rossi; Roberto Ratiglia; Stefano De Cillà; Paolo Nucci
Tags: glaucoma, neurons, conjunctiva, dendritic cells
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1003-1010. doi:https://doi.org/10.1167/iovs.15-17455
AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development Open Access
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Lisheng Chen; Vanessa Martino; Alan Dombkowski; Trevor Williams; Judith West-Mays; Philip J. Gage
Tags: angiogenesis, cornea, endothelium
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1072-1081. doi:https://doi.org/10.1167/iovs.15-18103
Diagnostic Efficacy of Normalization of Corneal Deformation Variables by the Intraocular Pressure in Glaucomatous Eyes Open Access
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Sushma Tejwani; Sathi Devi; Shoruba Dinakaran; Rohit Shetty; Priti Meshram; Mathew Francis; Abhijit Sinha Roy
Tags: cornea, eye, glaucoma, intraocular pressure, open-angle glaucoma
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1082-1086. doi:https://doi.org/10.1167/iovs.15-18569
Two-Dimensional Plane for Multi-Scale Quantification of Corneal Subbasal Nerve Tortuosity Open Access
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Roberto Annunziata; Ahmad Kheirkhah; Shruti Aggarwal; Bernardo M. Cavalcanti; Pedram Hamrah; Emanuele Trucco
Tags: cornea, neurons
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1132-1139. doi:https://doi.org/10.1167/iovs.15-18513
Effect of Salicylic Acid on the Membrane Proteome and Virulence of Pseudomonas aeruginosa Open Access
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Mahesh Bandara; Padmaja Sankaridurg; Hua Zhu; Emma Hume; Mark Willcox
Tags: proteome, salicylic acid, tissue membrane, pseudomonas aeruginosa, virulence
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1213-1220. doi:https://doi.org/10.1167/iovs.15-18990
Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing Open Access
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Naoki Okumura; Yugo Okazaki; Ryota Inoue; Kazuya Kakutani; Shinichiro Nakano; Shigeru Kinoshita; Noriko Koizumi
Tags: cornea, corneal endothelium, endothelium, eyedrops, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1284-1292. doi:https://doi.org/10.1167/iovs.15-18586
Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization Open Access
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Rongrong Zong; Tong Zhou; Zhirong Lin; Xiaorui Bao; Yanghui Xiu; Yanfeng Chen; Longlong Chen; Jian-xing Ma; Zuguo Liu; Yueping Zhou
Tags: corneal neovascularization, micrornas, down-regulation, sutures, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1398-1407. doi:https://doi.org/10.1167/iovs.15-17417
Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis Open Access
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Jing Hua; William Stevenson; Thomas H. Dohlman; Takenori Inomata; Maryam Tahvildari; Narghes Calcagno; Negar Pirmadjid; Zahra Sadrai; Sunil K. Chauhan; Reza Dana
Tags: beds, dendritic cells, tissue transplants, atrial premature complexes
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1457-1467. doi:https://doi.org/10.1167/iovs.15-17551

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Visual Field Outcomes for the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) Open Access
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Michael Wall; Chris A. Johnson; Kimberly E. Cello; K. D. Zamba; Michael P. McDermott; John L. Keltner; for the NORDIC Idiopathic Intracranial Hypertension Study Group
Tags: pseudotumor cerebri, visual fields, placebos, eye, acetazolamide
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 805-812. doi:https://doi.org/10.1167/iovs.15-18626
Vergence Adaptation to Short-Duration Stimuli in Early Childhood Open Access
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Erin Babinsky; Vidhyapriya Sreenivasan; T. Rowan Candy
Tags: adult, child, strabismus, prisms, eye
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 920-927. doi:https://doi.org/10.1167/iovs.15-17767
Prevalence and Associations of Anisometropia in Children Open Access
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Yuan Yuan Hu; Jian Feng Wu; Tai Liang Lu; Hui Wu; Wei Sun; Da Dong Guo; Wen Jun Jiang; Xing Rong Wang; Jost B. Jonas; Hong Sheng Bi
Tags: anisometropia, child, prevalence, eye, chinese (other dialects)
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 979-988. doi:https://doi.org/10.1167/iovs.15-18647
Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma Open Access
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Masoud Aghsaei Fard; Marjan Afzali; Parisa Abdi; Mehdi Yasseri; Katayoon B. Ebrahimi; Sasan Moghimi
Tags: eye, ganglia, glaucoma, nonarteritic anterior ischemic optic neuropathy, open-angle glaucoma
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1011-1016. doi:https://doi.org/10.1167/iovs.15-18618
Influence of Target Parameters on Fixation Stability in Normal and Strabismic Monkeys Open Access
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Onkar H. Pirdankar; Vallabh E. Das
Tags: cercopithecidae, eye, eye movement
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1087-1095. doi:https://doi.org/10.1167/iovs.15-17896
Changes in Extraocular Muscle Volume During Ocular Duction Open Access
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Robert A. Clark; Joseph L. Demer
Tags: muscle, muscle of orbit, volume, eye, magnetic resonance imaging
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1106-1111. doi:https://doi.org/10.1167/iovs.15-18705
Infantile Nystagmus and Abnormalities of Conjugate Eye Movements in Down Syndrome Open Access
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Avery H. Weiss; John P. Kelly; James O. Phillips
Tags: down syndrome, eye movement, pathologic nystagmus, saccades, gaze
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1301-1309. doi:https://doi.org/10.1167/iovs.15-18532

Genetics

Retinal Pigment Epithelium Atrophy 1 (rpea1): A New Mouse Model With Retinal Detachment Caused by a Disruption of Protein Kinase C, θ Open Access
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Xiaojie Ji; Ye Liu; Ron Hurd; Jieping Wang; Bernie Fitzmaurice; Patsy M. Nishina; Bo Chang
Tags: mice, protein kinase c, protein kinase c-theta, retinal detachment, retinal pigment epithelium atrophy
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 877-888. doi:https://doi.org/10.1167/iovs.15-17495
Genetic Analysis of the Rhodopsin Gene Identifies a Mosaic Dominant Retinitis Pigmentosa Mutation in a Healthy Individual Open Access
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Avigail Beryozkin; Gal Levy; Anat Blumenfeld; Segev Meyer; Prasanthi Namburi; Yair Morad; Libe Gradstein; Anand Swaroop; Eyal Banin; Dror Sharon
Tags: genes, genetic analysis, mosaicism, mutation, retinitis pigmentosa
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 940-947. doi:https://doi.org/10.1167/iovs.15-18702
Nonsyndromic Retinal Dystrophy due to Bi-Allelic Mutations in the Ciliary Transport Gene IFT140 Open Access
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Sarah Hull; Nicholas Owen; Farrah Islam; Dhani Tracey-White; Vincent Plagnol; Graham E. Holder; Michel Michaelides; Keren Carss; F. Lucy Raymond; Jean-Michel Rozet; Simon C. Ramsden; Graeme C. M. Black; Isabelle Perrault; Ajoy Sarkar; Mariya Moosajee; Andrew R. Webster; Gavin Arno; Anthony T. Moore
Tags: biological transport, genes, mutation, family
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1053-1062. doi:https://doi.org/10.1167/iovs.15-17976
Prevalence and Genetics of Leber Hereditary Optic Neuropathy in the Danish Population Open Access
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Thomas Rosenberg; Søren Nørby; Marianne Schwartz; Juliette Saillard; Paulo J. Magalhães; David Leroy; Erik C. Kann; Morten Duno
Tags: danish, genetics, optic atrophy, hereditary, leber, prevalence, mutation
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1370-1375. doi:https://doi.org/10.1167/iovs.15-18306

Glaucoma

The Effect of A2A Receptor Antagonist on Microglial Activation in Experimental Glaucoma Open Access
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Xiaohong Liu; Ping Huang; Jing Wang; Zijian Yang; Shouyue Huang; Xunda Luo; Jin Qi; Xi Shen; Yisheng Zhong
Tags: antagonists, glaucoma, glutamate, glutamates, microglia
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 776-786. doi:https://doi.org/10.1167/iovs.15-18024
Platelet-Derived Growth Factor Preserves Retinal Synapses in a Rat Model of Ocular Hypertension Open Access
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Rachel S. Chong; Andrew Osborne; Raquel Conceição; Keith R. Martin
Tags: ocular hypertension, platelet-derived growth factor, eye, retina, synapses
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 842-852. doi:https://doi.org/10.1167/iovs.15-17864
Effect of Focal Lamina Cribrosa Defect on Disc Hemorrhage Area in Glaucoma Open Access
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Young Kook Kim; Jin Wook Jeoung; Ki Ho Park
Tags: cribriform plate, eye, glaucoma, hemorrhage
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 899-907. doi:https://doi.org/10.1167/iovs.15-18389
Paclitaxel Associated With Lipid Nanoparticles as a New Antiscarring Agent in Experimental Glaucoma Surgery Open Access
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Marcelo L. Occhiutto; Fatima R. Freitas; Patrícia P. Lima; Raul C. Maranhão; Vital P. Costa
Tags: blister, glaucoma surgery, lipids, nanoparticles, paclitaxel
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 971-978. doi:https://doi.org/10.1167/iovs.15-18671
Revisiting Ciliary Muscle Tendons and Their Connections With the Trabecular Meshwork by Two Photon Excitation Microscopic Imaging Open Access
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Choul Yong Park; Jimmy K. Lee; Malik Y. Kahook; Jeffrey S. Schultz; Cheng Zhang; Roy S. Chuck
Tags: ciliary muscle, diagnostic imaging, excitation, photons, tendon
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1096-1105. doi:https://doi.org/10.1167/iovs.15-17091
Anatomical Variation of Human Collector Channel Orifices Open Access
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Michael D. Bentley; Cheryl R. Hann; Michael P. Fautsch
Tags: eye, schlemm's canal, surgical flaps, tissue dissection, endothelial cells
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1153-1159. doi:https://doi.org/10.1167/iovs.15-17753
Changes in Retinal Nerve Fiber Layer Reflectance Intensity as a Predictor of Functional Progression in Glaucoma Open Access
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Stuart K. Gardiner; Shaban Demirel; Juan Reynaud; Brad Fortune
Tags: glaucoma, eye, cohort studies
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1221-1227. doi:https://doi.org/10.1167/iovs.15-18788
Evaluation of Lamina Cribrosa and Choroid in Nonglaucomatous Patients With Pseudoexfoliation Syndrome Using Spectral-Domain Optical Coherence Tomography Open Access
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Sasan Moghimi; Mehdi Mazloumi; MohammadKarim Johari; Parisa Abdi; Ghasem Fakhraie; Massood Mohammadi; Reza Zarei; Yadollah Eslami; Masoud A. Fard; Shan C. Lin
Tags: choroid, cribriform plate, diagnostic imaging, exfoliation syndrome, eye
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1293-1300. doi:https://doi.org/10.1167/iovs.15-18312
A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork Open Access
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Ralitsa T. Loewen; Pritha Roy; Daniel B. Park; Adrianna Jensen; Gordon Scott; Devora Cohen-Karni; Michael P. Fautsch; Joel S. Schuman; Nils A. Loewen
Tags: direct visualization, eye, perfusion, suidae, trabecular meshwork
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1338-1344. doi:https://doi.org/10.1167/iovs.15-18125
The Relationship of the Clinical Disc Margin and Bruch's Membrane Opening in Normal and Glaucoma Subjects Open Access
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Navid Amini; Arezoo Miraftabi; Sharon Henry; Norman Chung; Sarah Nowroozizadeh; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: glaucoma, bruch's basal membrane, eye
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1468-1475. doi:https://doi.org/10.1167/iovs.15-18382

Immunology and Microbiology

Natural Killer T Cells Contribute to Neutrophil Recruitment and Ocular Tissue Damage in a Model of Intraocular Tumor Rejection Open Access
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Ann J. Ligocki; Jerry Y. Niederkorn
Tags: eye neoplasms, mice, natural killer t-cells, neoplasms, neutrophil infiltration
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 813-823. doi:https://doi.org/10.1167/iovs.15-18786
Topical Administration of β-1,3-Glucan to Modulate Allergic Conjunctivitis in a Murine Model Open Access
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Hyun Soo Lee; Ji Young Kwon; Choun-Ki Joo
Tags: administration, topical, allergic conjunctivitis, glucans, immunoglobulin e, mice
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1352-1360. doi:https://doi.org/10.1167/iovs.15-17914
Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration Open Access
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Samuel J. H. Hinshaw; Osato Ogbeifun; Wambui S. Wandu; Cancan Lyu; Guangpu Shi; Yichao Li; Haohua Qian; Igal Gery
Tags: digoxin, mice, retinal degeneration, uveitis
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1441-1447. doi:https://doi.org/10.1167/iovs.15-19040

Lens

Hyperglycemia Enhances the Production of Amyloid β1–42 in the Lenses of Otsuka Long-Evans Tokushima Fatty Rats, a Model of Human Type 2 Diabetes Open Access
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Noriaki Nagai; Yoshimasa Ito; Hiroshi Sasaki
Tags: amyloid, diabetes mellitus, type 2, glucose, hyperglycemia, lens (device)
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1408-1417. doi:https://doi.org/10.1167/iovs.15-19026

Low Vision

Depth Perception and Grasp in Central Field Loss Open Access
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Preeti Verghese; Terence L. Tyson; Saeideh Ghahghaei; Donald C. Fletcher
Tags: depth perception, eye, scotoma, macular degeneration, contrast sensitivity
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1476-1487. doi:https://doi.org/10.1167/iovs.15-18336

Multidisciplinary Ophthalmic Imaging

Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy Open Access
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Sachi Kojima; Toshihiro Inoue; Junichi Kikuta; Masayuki Furuya; Ayaka Koga; Tomokazu Fujimoto; Mayumi Ueta; Shigeru Kinoshita; Masaru Ishii; Hidenobu, Tanihara
Tags: conjunctiva, diagnostic imaging, surgical procedures, operative, wounds and injuries, mice
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1207-1212. doi:https://doi.org/10.1167/iovs.15-18507

Physiology and Pharmacology

Effects of Dorzolamide on Retinal and Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma Open Access
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Saurav Chandra; Eric R. Muir; Kaiwalya Deo; Jeffrey W. Kiel; Timothy Q. Duong
Tags: dorzolamide, glaucoma, intraocular pressure, magnetic resonance imaging, mice
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 826-831. doi:https://doi.org/10.1167/iovs.15-18291
PDGF-BB Enhances the Proliferation of Cells in Human Orbital Fibroblasts by Suppressing PDCD4 Expression Via Up-Regulation of microRNA-21 Open Access
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Ji-Young Lee; Mihee Yun; Ji-Sun Paik; Seong-Beom Lee; Suk-Woo Yang
Tags: fibroblasts, micrornas, platelet-derived growth factor, transfection, up-regulation (physiology)
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 908-913. doi:https://doi.org/10.1167/iovs.15-18157
Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury Open Access
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Francisco M. Nadal-Nicolás; Esther Rodriguez-Villagra; Irene Bravo-Osuna; Paloma Sobrado-Calvo; Irene Molina-Martínez; Maria Paz Villegas-Pérez; Manuel Vidal-Sanz; Marta Agudo-Barriuso; Rocío Herrero-Vanrell
Tags: ketorolac, wounds and injuries, microspheres, retinal ganglion cells
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1183-1192. doi:https://doi.org/10.1167/iovs.15-18213
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes Open Access
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Pei Ge; Iris D. Navarro; Marco M. Kessler; Sylvie G. Bernier; Nicholas R. Perl; Renee Sarno; Jaime Masferrer; Gerhard Hannig; W. Daniel Stamer
Tags: cyclic gmp, eye, mice, soluble guanylyl cyclase, deet
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1317-1326. doi:https://doi.org/10.1167/iovs.15-18958

Retina

Fluorescence Lifetime Imaging in Stargardt Disease: Potential Marker for Disease Progression Open Access
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Chantal Dysli; Sebastian Wolf; Katja Hatz; Martin S. Zinkernagel
Tags: diagnostic imaging, disease progression, fluorescence, stargardt's disease, autofluorescence
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 832-841. doi:https://doi.org/10.1167/iovs.15-18033
Impairment of Vision in a Mouse Model of Usher Syndrome Type III Open Access
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Guilian Tian; Richard Lee; Philip Ropelewski; Yoshikazu Imanishi
Tags: electroretinography, mice, usher syndrome, vision, impairment
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 866-875. doi:https://doi.org/10.1167/iovs.15-16946
Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment Open Access
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Misato Kobayashi; Takeshi Iwase; Kentaro Yamamoto; Eimei Ra; Kenta Murotani; Shigeyuki Matsui; Hiroko Terasaki
Tags: eye, surgical procedures, operative, macula densa, macula lutea, rhegmatogenous retinal detachment
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 889-898. doi:https://doi.org/10.1167/iovs.15-18403
Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice Open Access
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Katharina Kruszewski; Renate Lüllmann-Rauch; Thomas Dierks; Udo Bartsch; Markus Damme
Tags: mice, photoreceptors, retina, sulfatases, phenotype
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1120-1131. doi:https://doi.org/10.1167/iovs.15-17645
Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study Open Access
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Seydou Alassane; Christine Binquet; Vanessa Cottet; Olivier Fleck; Niyazi Acar; Sandrine Daniel; Cécile Delcourt; Lionel Bretillon; Alain M. Bron; Catherine Creuzot-Garcher
Tags: diet, lutein, older adult, optics, plasma
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1160-1167. doi:https://doi.org/10.1167/iovs.15-18007
FTY720 Attenuates Retinal Inflammation and Protects Blood–Retinal Barrier in Diabetic Rats Open Access
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Lingling Fan; Hua Yan
Tags: diabetes mellitus, fingolimod, rats, inflammation
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1254-1263. doi:https://doi.org/10.1167/iovs.15-18658
Overweight, Obesity, and Risk of Age-Related Macular Degeneration Open Access
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Qian-Yu Zhang; Li-Jun Tie; Shan-Shan Wu; Pei-Lin Lv; Hong-Wei Huang; Wei-Qing Wang; Hui Wang; Le Ma
Tags: age-related macular degeneration, body mass index procedure, obesity, overweight, body weight
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1276-1283. doi:https://doi.org/10.1167/iovs.15-18637
Reticular Pseudodrusen in Intermediate Age-Related Macular Degeneration: Prevalence, Detection, Clinical, Environmental, and Genetic Associations Open Access
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Zhichao Wu; Lauren N. Ayton; Chi D. Luu; Paul N. Baird; Robyn H. Guymer
Tags: age-related macular degeneration, diagnostic imaging, drusen, eye, genetics
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1310-1316. doi:https://doi.org/10.1167/iovs.15-18682
Effects of Habitual Cigarette Smoking on Retinal Circulation in Patients With Type 2 Diabetes Open Access
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Tsuneaki Omae; Taiji Nagaoka; Akitoshi Yoshida
Tags: diabetes mellitus, type 2, retina circulation, smoking, vascular flow
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1345-1351. doi:https://doi.org/10.1167/iovs.15-18813
Elevated Fundus Autofluorescence in Monkeys Deficient in Lutein, Zeaxanthin, and Omega-3 Fatty Acids Open Access
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Trevor J. McGill; Lauren M. Renner; Martha Neuringer
Tags: cercopithecidae, diet, fundus autofluorescence imaging, lutein, omega-3 fatty acids
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1361-1369. doi:https://doi.org/10.1167/iovs.15-18596
HIV-Associated Neuroretinal Disorder in Patients With Well-Suppressed HIV-Infection: A Comparative Cohort Study Open Access
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Nazli Demirkaya; Ferdinand W. N. M. Wit; Thomas J. T. P. van Den Berg; Katherine W. Kooij; Maria Prins; Reinier O. Schlingemann; Michael D. Abramoff; Peter Reiss; Frank D. Verbraak; on behalf of the AGEhIV Cohort Study Group
Tags: cohort studies, hiv, hiv infections, contrast sensitivity
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1388-1397. doi:https://doi.org/10.1167/iovs.15-18537
Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method Open Access
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Reinhard Told; Lin Wang; Grant Cull; Simon J. Thompson; Claude F. Burgoyne; Gerold C. Aschinger; Leopold Schmetterer; René M. Werkmeister
Tags: microspheres, optical coherence tomography, vascular flow, optic nerve, primates
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1432-1440. doi:https://doi.org/10.1167/iovs.16-19140
Perception of Haidinger Brushes in Macular Disease Depends on Macular Pigment Density and Visual Acuity Open Access
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Philipp L. Müller; Simone Müller; Martin Gliem; Kristina Küpper; Frank G. Holz; Wolf M. Harmening; Peter Charbel Issa
Tags: macular disorders, perception, visual acuity, eye
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1448-1456. doi:https://doi.org/10.1167/iovs.15-19004
Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina Open Access
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Amelia R. Bachleda; Larysa H. Pevny; Ellen R. Weiss
Tags: ablation, neuroglia, retina, mammals, control groups
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1488-1499. doi:https://doi.org/10.1167/iovs.15-17994
Geographic Atrophy and Activity of Neovascularization in Retinal Angiomatous Proliferation Open Access
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Jiwon Baek; Jae Hyung Lee; Jun Yong Kim; Na Hyun Kim; Won Ki Lee
Tags: atrophy, eye, follow-up, injections, neovascularization, pathologic
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1500-1505. doi:https://doi.org/10.1167/iovs.15-18837

Retinal Cell Biology

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration Open Access
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Dibyendu Chakraborty; Shannon M. Conley; Steven J. Pittler; Muna I. Naash
Tags: proteins, retinal degeneration, rhodopsin, retina, excretory function
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 787-797. doi:https://doi.org/10.1167/iovs.15-18516
PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity Open Access
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Jared Iacovelli; Glenn C. Rowe; Arogya Khadka; Daniel Diaz-Aguilar; Carrie Spencer; Zoltan Arany; Magali Saint-Geniez
Tags: antioxidants, cell respiration, gene expression, metabolism, proteins
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1038-1051. doi:https://doi.org/10.1167/iovs.15-17758
DNA Damage Response in Proliferating Müller Glia in the Mammalian Retina Open Access
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Kaori Nomura-Komoike; Fuminori Saitoh; Yuta Komoike; Hiroki Fujieda
Tags: dna damage, neuroglia, retina, mammals, photoreceptors
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1169-1182. doi:https://doi.org/10.1167/iovs.15-18101
The cKit Inhibitor, Masitinib, Prevents Diabetes-Induced Retinal Vascular Leakage Open Access
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So Ra Kim; Ji-Eun Im; Ji Hoon Jeong; Ji Yeon Kim; Jee Taek Kim; Se Joon Woo; Jong-Hyuk Sung; Sang Gyu Park; Wonhee Suh
Tags: diabetes mellitus, endothelium, streptozocin, cadherins
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1201-1206. doi:https://doi.org/10.1167/iovs.15-18065
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction Open Access
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Parameswaran G. Sreekumar; Keijiro Ishikawa; Chris Spee; Hemal H. Mehta; Junxiang Wan; Kelvin Yen; Pinchas Cohen; Ram Kannan; David R. Hinton
Tags: mitochondria, oxidative stress, peptides, aging, older adult
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1238-1253. doi:https://doi.org/10.1167/iovs.15-17053

Visual Neuroscience

The Effect of Electric Cross-Talk in Retinal Neurostimulation Open Access
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Paul B. Matteucci; Alejandro Barriga-Rivera; Calvin D. Eiber; Nigel H. Lovell; John W. Morley; Gregg J. Suaning
Tags: cats, linear regression, platinum, surgical procedures, operative, neuroprosthesis
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1031-1037. doi:https://doi.org/10.1167/iovs.15-18400
Temporal Properties of Cone ERGs of Pikachurin Null Mutant Mouse Open Access
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Taro Kominami; Shinji Ueno; Ayami Nakanishi; Azusa Kominami; Mineo Kondo; Takahisa Furukawa; Hiroko Terasaki
Tags: mice, photopsia, retinal cone, electroretinography, spatial vectors
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1264-1269. doi:https://doi.org/10.1167/iovs.15-17708
Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling Open Access
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Johnnie M. Moore-Dotson; Jamie J. Beckman; Reece E. Mazade; Mrinalini Hoon; Adam S. Bernstein; Melissa J. Romero-Aleshire; Heddwen L. Brooks; Erika D. Eggers
Tags: diabetes mellitus, retinal bipolar cells, rod photoreceptors, diabetes mellitus, type 2, mice
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1418-1430. doi:https://doi.org/10.1167/iovs.15-17999

Visual Psychophysics and Physiological Optics

A Robust and Reliable Test to Measure Stereopsis in the Clinic Open Access
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Robert F. Hess; Rifeng Ding; Simon Clavagnier; Catherine Liu; Cindy Guo; Catherine Viner; Brendan T. Barrett; Krupali Radia; Jiawei Zhou
Tags: depth perception, aniseikonia
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 798-804. doi:https://doi.org/10.1167/iovs.15-18690
The Stereoscopic Anisotropy Develops During Childhood Open Access
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Ignacio Serrano-Pedraza; William Herbert; Laura Villa-Laso; Michael Widdall; Kathleen Vancleef; Jenny C. A. Read
Tags: anisotropy, child, health disparity
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 960-970. doi:https://doi.org/10.1167/iovs.15-17766
Corneal Biomechanical Response Following Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA Open Access
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Nandor Bekesi; Irene E. Kochevar; Susana Marcos
Tags: cornea, riboflavin, rose bengal, ultraviolet a radiation, eye
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 992-1001. doi:https://doi.org/10.1167/iovs.15-18689
Heterochromatic Flicker Photometry for Objective Lens Density Quantification Open Access
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Raymond P. Najjar; Petteri Teikari; Pierre-Loïc Cornut; Kenneth Knoblauch; Howard M. Cooper; Claude Gronfier
Tags: lens (device), lens, crystalline, photometry, photopsia, diagnostic imaging
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1063-1071. doi:https://doi.org/10.1167/iovs.15-18642
Enhanced Motion Aftereffects in Migraine Are Related to Contrast Sensitivity: Implications for Models of Differences in Precortical/Cortical Function Open Access
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Pia Singh; Alex J. Shepherd
Tags: contrast sensitivity, migraine disorders, motion
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1228-1234. doi:https://doi.org/10.1167/iovs.15-17692

Review

Potential Therapeutic Agents Against Retinal Diseases Caused by Aberrant Metabolism of Retinoids Open Access
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Xin Liu; Jingmeng Chen; Zhe Liu; Jie Li; Ke Yao; Yalin Wu
Tags: metabolism, retinal diseases, retinoids
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1017-1030. doi:https://doi.org/10.1167/iovs.15-18429

Perspective

Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve Open Access
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Jeffrey L. Goldberg; William Guido; for the AGI Workshop Participants
Tags: eye, maryland, united states national institutes of health, optic nerve, universities
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1271-1275. doi:https://doi.org/10.1167/iovs.15-18500

Lecture

Introducing Anneke I. den Hollander, the Recipient of the 2015 Cogan Award Open Access
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Martine J. Jager
Tags: awards and prizes
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1376-1377. doi:https://doi.org/10.1167/iovs.16-19380
Omics in Ophthalmology: Advances in Genomics and Precision Medicine for Leber Congenital Amaurosis and Age-Related Macular Degeneration Open Access
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Anneke I. den Hollander
Tags: age-related macular degeneration, genes, genetic screening, genetics, genomics
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1378-1387. doi:https://doi.org/10.1167/iovs.15-18167

Letters to the Editor

Choroidal Abnormalities Detected by Near-Infrared Imaging (NIR) in Pediatric Patients With Neurofibromatosis Type 1 (NF1) Open Access
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Aldo Vagge; Paolo Capris; Carlo Enrico Traverso
Tags: diagnostic imaging, neurofibromatosis 1, pediatrics
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 774. doi:https://doi.org/10.1167/iovs.15-18603
Author Response: Choroidal Abnormalities Detected by Near-Infrared Imaging (NIR) in Pediatric Patients With Neurofibromatosis Type 1 (NF1) Open Access
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Raffaele Parrozzani; Edoardo Midena
Tags: diagnostic imaging, neurofibromatosis 1, pediatrics
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 775. doi:https://doi.org/10.1167/iovs.15-18829
Light Levels and the Development of Deprivation Myopia Open Access
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Virgilio Galvis; Alejandro Tello; M. Margarita Parra
Tags: myopia
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 824. doi:https://doi.org/10.1167/iovs.15-18639
Author Response: Light Levels and the Development of Deprivation Myopia Open Access
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Cindy Karouta; Regan Ashby
Tags: myopia
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 825. doi:https://doi.org/10.1167/iovs.15-18959
Formation of Macular Inner Nuclear Layer Cysts in Optic Atrophy Open Access
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Kim Jiramongkolchai; M. Tariq Bhatti; Alan Proia; Sharon F. Freedman; Mays A. El-Dairi
Tags: cysts, optic atrophy
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 989-991. doi:https://doi.org/10.1167/iovs.15-18814
A Diagnostic Calculator for Detecting Glaucoma and False Positive Using Cirrus OCT Open Access
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Javier Moreno-Montañés; Marina Leal-Fonseca; Noelia Oblanca; Francisco J. Muñoz-Negrete; Gema Rebolleda
Tags: false-positive results, glaucoma
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1052. doi:https://doi.org/10.1167/iovs.15-19048
Comments on Progressive Thinning of Regional Macular Thickness After Epiretinal Membrane Surgery Open Access
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Shorya Azad; Brijesh Takkar
Tags: epiretinal membrane, surgical procedures, operative
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1235. doi:https://doi.org/10.1167/iovs.15-18653
Author Response: Progressive Thinning of Regional Macular Thickness After Epiretinal Membrane Surgery Open Access
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Kazuyuki Kumagai; Masanori Hangai
Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1236-1237. doi:https://doi.org/10.1167/iovs.16-19081

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science March 2016, Vol.57, 876. doi:https://doi.org/10.1167/iovs.15-17930a
Erratum Open Access
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Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1168. doi:https://doi.org/10.1167/iovs.15-18565a
Erratum Open Access
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Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1270. doi:https://doi.org/10.1167/iovs.15-17195a
Erratum Open Access
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Investigative Ophthalmology & Visual Science March 2016, Vol.57, 1431. doi:https://doi.org/10.1167/iovs.15-18276A
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