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Research Highlight

A Proposed New Measure of Corneal Sensitivity Open Access
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Nathan Efron
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2420. doi:https://doi.org/10.1167/iovs.16-19721
Capsulorhexis Strength With FLACS Surgery Open Access
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David Spalton
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2850. doi:https://doi.org/10.1167/iovs.16-19629
RACking Up Retinal Oxidative Stress Open Access
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Joshua L. Dunaief
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2876. doi:https://doi.org/10.1167/iovs.16-19764

Anatomy and Pathology/Oncology

Growth and Metastasis of Intraocular Tumors in Aged Mice Open Access
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Zhiqiang Han; Joseph R. Brown; Jerry Y. Niederkorn
Tags: eye neoplasms, mice, neoplasm metastasis, neoplasms, uveal melanoma
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2366-2376. doi:https://doi.org/10.1167/iovs.16-19156
Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca2+ Influx Dysfunction in Human Pterygial Cells Open Access
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Fabian Garreis; Antje Schröder; Peter S. Reinach; Stefanie Zoll; Noushafarin Khajavi; Priyavathi Dhandapani; Alexander Lucius; Uwe Pleyer; Friedrich Paulsen; Stefan Mergler
Tags: pterygium, up-regulation (physiology), pathophysiology, vascular endothelial growth factor a, reverse transcriptase polymerase chain reaction
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2564-2577. doi:https://doi.org/10.1167/iovs.16-19170

Biochemistry and Molecular Biology

Mitochondrial ND1 Variants in 1281 Chinese Subjects With Leber's Hereditary Optic Neuropathy Open Access
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Yanchun Ji; Min Liang; Juanjuan Zhang; Ling Zhu; Zengjun Zhang; Runing Fu; Xiaoling Liu; Minglian Zhang; Qun Fu; Fuxin Zhao; Yi Tong; Yanhong Sun; Pingping Jiang; Min-Xin Guan
Tags: chinese people, mutation, optic atrophy, hereditary, leber, proband, mitochondria
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2377-2389. doi:https://doi.org/10.1167/iovs.16-19243
The Urokinase Receptor-Derived Peptide UPARANT Mitigates Angiogenesis in a Mouse Model of Laser-Induced Choroidal Neovascularization Open Access
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Maurizio Cammalleri; Massimo Dal Monte; Filippo Locri; Liliana Lista; Monica Aronsson; Anders Kvanta; Dario Rusciano; Mario De Rosa; Vincenzo Pavone; Helder André; Paola Bagnoli
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2600-2611. doi:https://doi.org/10.1167/iovs.15-18758

Clinical and Epidemiologic Research

Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD) Open Access
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Monika Fleckenstein; Felix Grassmann; Moritz Lindner; Maximilian Pfau; Joanna Czauderna; Tobias Strunz; Claudia von Strachwitz; Steffen Schmitz-Valckenberg; Frank G. Holz; Bernhard H. F. Weber
Tags: age-related macular degeneration, atrophy, genes, genetic risk, phenotype
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2463-2471. doi:https://doi.org/10.1167/iovs.15-18593
Prevalence of Glaucoma in the United States: The 2005–2008 National Health and Nutrition Examination Survey Open Access
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Priya Gupta; Di Zhao; Eliseo Guallar; Fang Ko; Michael V. Boland; David S. Friedman
Tags: glaucoma, national health and nutrition examination survey, prevalence
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2905-2913. doi:https://doi.org/10.1167/iovs.15-18469

Cornea

3D Corneal Shape After Implantation of a Biosynthetic Corneal Stromal Substitute Open Access
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Jeb A. Ong; Edouard Auvinet; Karolyn J. Forget; Neil Lagali; Per Fagerholm; May Griffith; Jean Meunier; Isabelle Brunette
Tags: cornea, implantation procedure
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2355-2365. doi:https://doi.org/10.1167/iovs.15-18271
Sebum/Meibum Surface Film Interactions and Phase Transitional Differences Open Access
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Poonam Mudgil; Douglas Borchman; Dylan Gerlach; Marta C. Yappert
Tags: lipids, sebum
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2401-2411. doi:https://doi.org/10.1167/iovs.16-19117
Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy Open Access
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Matthew S. Yorek; Eric P. Davidson; Pieter Poolman; Lawrence J. Coppey; Alexander Obrosov; Amey Holmes; Randy H. Kardon; Mark A. Yorek
Tags: cornea, diabetic neuropathies, eyedrops, hyperosmolality, hyperosmolar hyperglycemia
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2412-2419. doi:https://doi.org/10.1167/iovs.16-19435
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model Open Access
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Ken T. Simmons; Yangyan Xiao; Stephen C. Pflugfelder; Cintia S. de Paiva
Tags: dry eye syndromes, lipopolysaccharides, mice, toll-like receptor 4, conjunctiva
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2443-2451. doi:https://doi.org/10.1167/iovs.15-18396
ω-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye Open Access
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Scott D. Walter; Karsten Gronert; Allison L. McClellan; Roy C. Levitt; Konstantinos D. Sarantopoulos; Anat Galor
Tags: dry eye syndromes, lipids, tear film finding, signs and symptoms, lipid mediators
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2472-2478. doi:https://doi.org/10.1167/iovs.16-19131
Differential Expression of Proteoglycans by Corneal Stromal Cells in Keratoconus Open Access
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Beatriz García; Olivia García-Suárez; Jesús Merayo-Lloves; Ignacio Alcalde; José F. Alfonso; Luis Fernández-Vega Cueto; Álvaro Meana; Fernando Vázquez; Luis M. Quirós
Tags: cornea, corneal stroma, genes, keratoconus, phosphatidylglycerols
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2618-2628. doi:https://doi.org/10.1167/iovs.15-16692
Pigment Epithelial-Derived Factor Peptide Regenerated Limbus Serves as Regeneration Source for Limbal Regeneration in Rabbit Limbal Deficiency Open Access
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Shu-I Yeh; Tsung-Chuan Ho; Show-Li Chen; Chie-Pein Chen; Huey-Chuan Cheng; Yu-Wen Lan; Jui-Wen Hsieh; Chin-Tien Wang; Yeou-Ping Tsao
Tags: epithelium, oryctolagus cuniculus, peptides, pigment, excision
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2629-2636. doi:https://doi.org/10.1167/iovs.15-17171
Corneal Structural Changes in Nonneoplastic and Neoplastic Monoclonal Gammopathies Open Access
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Pasquale Aragona; Alessandro Allegra; Elisa Imelde Postorino; Laura Rania; Vanessa Innao; Edward Wylegala; Anna Nowinska; Antonio Ieni; Antonina Pisani; Caterina Musolino; Domenico Puzzolo; Antonio Micali
Tags: cornea, monoclonal gammopathy of undetermined significance, paraproteinemias, keratocytes, hematology
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2657-2665. doi:https://doi.org/10.1167/iovs.15-18594
Vitamin D Induces Global Gene Transcription in Human Corneal Epithelial Cells: Implications for Corneal Inflammation Open Access
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Rose Y. Reins; Fahmi Mesmar; Cecilia Williams; Alison M. McDermott
Tags: vitamin d, corneal epithelial cells, keratitis, genes, transcription, genetic
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2689-2698. doi:https://doi.org/10.1167/iovs.16-19237
Novel Identity and Functional Markers for Human Corneal Endothelial Cells Open Access
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Alena Bartakova; Karen Alvarez-Delfin; Alejandra D. Weisman; Enrique Salero; Gabriella A. Raffa; Richard M. Merkhofer, Jr; Noelia J. Kunzevitzky; Jeffrey L. Goldberg
Tags: cornea, endothelial cells, flow cytometry, endothelium, body tissue
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2749-2762. doi:https://doi.org/10.1167/iovs.15-18826
In Vivo Imaging and Morphometry of the Human Pre-Descemet's Layer and Endothelium With Ultrahigh-Resolution Optical Coherence Tomography Open Access
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Kostadinka Bizheva; Lacey Haines; Erik Mason; Benjamin MacLellan; Bingyao Tan; Denise Hileeto; Luigina Sorbara
Tags: cornea, diagnostic imaging, endothelium, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2782-2787. doi:https://doi.org/10.1167/iovs.15-18936
Time Course of Changes in Goblet Cell Density in Symptomatic and Asymptomatic Contact Lens Wearers Open Access
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Luisa H. Colorado; Yahya Alzahrani; Nicola Pritchard; Nathan Efron
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2888-2894. doi:https://doi.org/10.1167/iovs.16-19298

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Congenitally Impaired Disparity Vergence in Children With Infantile Esotropia Open Access
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Krista R. Kelly; Joost Felius; Santoshi Ramachandran; Blesson A. John; Reed M. Jost; Eileen E. Birch
Tags: child, esotropia, health disparity, infantile esotropia, eye movement
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2545-2551. doi:https://doi.org/10.1167/iovs.15-18606
Objective Measurement of Fusional Vergence Ranges and Heterophoria in Infants and Preschool Children Open Access
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Vidhyapriya Sreenivasan; Erin E. Babinsky; Yifei Wu; T. Rowan Candy
Tags: infant, preschool child, strabismus, adult, prisms
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2678-2688. doi:https://doi.org/10.1167/iovs.15-17877

Genetics

Biallelic Mutations in CRB1 Underlie Autosomal Recessive Familial Foveal Retinoschisis Open Access
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Ajoy Vincent; Judith Ng; Christina Gerth-Kahlert; Erika Tavares; Jason T. Maynes; Thomas Wright; Amit Tiwari; Anupreet Tumber; Shuning Li; James V. M. Hanson; Angela Bahr; Heather MacDonald; Luzy Bähr; Carol Westall; Wolfgang Berger; Frans P. M. Cremers; Anneke I. den Hollander; Elise Héon
Tags: autosomal recessive inheritance, family, genetics, mutation, phenotype
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2637-2646. doi:https://doi.org/10.1167/iovs.15-18281
MRI Evidence of Cerebellar and Extraocular Muscle Atrophy Differently Contributing to Eye Movement Abnormalities in SCA2 and SCA28 Diseases Open Access
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Letterio Salvatore Politi; Stefania Bianchi Marzoli; Claudia Godi; Marta Panzeri; Paola Ciasca; Gianluca Brugnara; Anna Castaldo; Daniela Di Bella; Franco Taroni; Lorenzo Nanetti; Caterina Mariotti
Tags: abnormal ocular motility, atrophy, cerebellum, magnetic resonance imaging, muscle of orbit
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2714-2720. doi:https://doi.org/10.1167/iovs.15-18732
Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk Open Access
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Anne E. Hughes; Stephen Bridgett; Weihua Meng; Mingyao Li; Christine A. Curcio; Dwight Stambolian; Declan T. Bradley
Tags: age-related macular degeneration, complement factor h, genes, haplotypes, gene clusters
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2763-2769. doi:https://doi.org/10.1167/iovs.15-18744
Disease-Phenotype Deconvolution in Genetic Eye Diseases Using Online Mendelian Inheritance in Man Open Access
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Priyanka Pandey; Moulinath Acharya
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2895-2904. doi:https://doi.org/10.1167/iovs.15-18057

Glaucoma

Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements Open Access
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Xiaofei Wang; Helmut Rumpel; Winston Eng Hoe Lim; Mani Baskaran; Shamira A. Perera; Monisha E. Nongpiur; Tin Aung; Dan Milea; Michaël J. A. Girard
Tags: eye, eye movement, magnetic resonance imaging, optic disk, body tissue
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2452-2462. doi:https://doi.org/10.1167/iovs.15-18986
Assessing Efficacy of Canaloplasty Using Continuous 24-Hour Monitoring of Ocular Dimensional Changes Open Access
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Marek Rękas; Monika E. Danielewska; Anna Byszewska; Katarzyna Petz; Joanna Wierzbowska; Robert Wierzbowski; D. Robert Iskander
Tags: eye, glaucoma, intraocular pressure, surgical procedures, operative, pharmaceutical preparations
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2533-2542. doi:https://doi.org/10.1167/iovs.16-19185
Lens Position Parameters as Predictors of Intraocular Pressure Reduction After Cataract Surgery in Glaucomatous Versus Nonglaucomatous Eyes Open Access
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Paul Coh; Sasan Moghimi; Rebecca I. Chen; Chi-Hsin Hsu; Marissé Masís Solano; Travis Porco; Shan C. Lin
Tags: cataract surgery, eye, glaucoma, intraocular pressure, lens (device)
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2593-2599. doi:https://doi.org/10.1167/iovs.16-19384
Effects of Peripapillary Scleral Stiffening on the Deformation of the Lamina Cribrosa Open Access
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Baptiste Coudrillier; Ian C. Campbell; A. Thomas Read; Diogo M. Geraldes; Nghia T. Vo; Andrew Feola; John Mulvihill; Julie Albon; Richard L. Abel; C. Ross Ethier
Tags: glutaral, sclera
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2666-2677. doi:https://doi.org/10.1167/iovs.15-18193
Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma Open Access
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Jamie L. Odden; Aleksandra Mihailovic; Michael V. Boland; David S. Friedman; Sheila K. West; Pradeep Y. Ramulu
Tags: glaucoma, visual fields, eye
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2797-2804. doi:https://doi.org/10.1167/iovs.15-19053
eNOS Activity in CAV1 Knockout Mouse Eyes Open Access
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Yuan Lei; Maomao Song; Jihong Wu; Chao Xing; Xinghuai Sun
Tags: eye, intraocular pressure, mice, nitric oxide synthase, mice, knockout
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2805-2813. doi:https://doi.org/10.1167/iovs.15-18841
Continuous Intraocular Pressure Monitoring During Nocturnal Sleep in Patients With Obstructive Sleep Apnea Syndrome Open Access
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Yasuhiro Shinmei; Takuya Nitta; Hiroshi Saito; Takeshi Ohguchi; Riki Kijima; Shinki Chin; Susumu Ishida
Tags: apnea, intraocular pressure, night time, obstructive sleep apnea, sleep
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2824-2830. doi:https://doi.org/10.1167/iovs.16-19220
Quantification of Focal Outflow Enhancement Using Differential Canalograms Open Access
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Ralitsa T. Loewen; Eric N. Brown; Gordon Scott; Hardik Parikh; Joel S. Schuman; Nils A. Loewen
Tags: ablation, eye, fluid flow, nose, fluorescence
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2831-2838. doi:https://doi.org/10.1167/iovs.16-19541
Cupping in the Monkey Optic Nerve Transection Model Consists of Prelaminar Tissue Thinning in the Absence of Posterior Laminar Deformation Open Access
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Eliesa Ing; Kevin M. Ivers; Hongli Yang; Stuart K. Gardiner; Juan Reynaud; Grant Cull; Lin Wang; Claude F. Burgoyne
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2914-2927. doi:https://doi.org/10.1167/iovs.15-18975

Immunology and Microbiology

Differentiated Expression Patterns and Phagocytic Activities of Type 1 and 2 Microglia Open Access
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Akira Haga; Eri Takahashi; Yasuya Inomata; Koichi Kawahara; Hidenobu Tanihara
Tags: interleukin-4, microglia
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2814-2823. doi:https://doi.org/10.1167/iovs.15-18509

Lens

The Impact of Cataract, and Its Surgical Removal, on Measures of Macular Pigment Using the Heidelberg Spectralis HRA+OCT MultiColor Device Open Access
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Kwadwo Owusu Akuffo; John M. Nolan; Jim Stack; Rebecca Power; Clare Kirwan; Rachel Moran; Laura Corcoran; Niamh Owens; Stephen Beatty
Tags: cataract, cataract surgery, eye, excision
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2552-2563. doi:https://doi.org/10.1167/iovs.16-19141
Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy Open Access
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Magaly Reyes Lua; Philipp Oertle; Leon Camenzind; Alexandra Goz; Carsten H. Meyer; Katarzyna Konieczka; Marko Loparic; Willi Halfter; Paul Bernhard Henrich
Tags: femtosecond pulsed lasers, free immunoglobulin light chain, laminin, lasers, lens capsule, crystalline
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2839-2849. doi:https://doi.org/10.1167/iovs.15-18355

Physiology and Pharmacology

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation Open Access
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Andreia Gonçalves; Cheng-Mao Lin; Arivalagan Muthusamy; Carlos Fontes-Ribeiro; António F. Ambrósio; Steven F. Abcouwer; Rosa Fernandes; David A. Antonetti
Tags: blood-retinal barrier, glucagon-like peptide 1, inflammation, ischemia, microglia
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2584-2592. doi:https://doi.org/10.1167/iovs.15-19006
Intraocular Pharmacokinetics of Intravitreal Aflibercept (Eylea) in a Rabbit Model Open Access
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Sang Jun Park; Yewon Choi; Young Mi Na; Hye Kyoung Hong; Ji Yeon Park; Kyu Hyung Park; Jae Yong Chung; Se Joon Woo
Tags: aflibercept, oryctolagus cuniculus, pharmacokinetics, vitreous body
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2612-2617. doi:https://doi.org/10.1167/iovs.16-19204
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia Open Access
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William H. Garner; Margaret H. Garner
Tags: disulfides, elasticity, lens (device), lens, crystalline, proteins
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2851-2863. doi:https://doi.org/10.1167/iovs.15-18413

Retina

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening Open Access
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Allen Clermont; Nivetha Murugesan; Qunfang Zhou; Takeshi Kita; Peter A. Robson; Louise J. Rushbrooke; D. Michael Evans; Lloyd Paul Aiello; Edward P. Feener
Tags: edema, plasma kallikrein, vascular endothelial growth factor a, mice, retina
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2390-2399. doi:https://doi.org/10.1167/iovs.15-18272
Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome Open Access
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Lynn W. Sun; Ryan D. Johnson; Christopher S. Langlo; Robert F. Cooper; Moataz M. Razeen; Madia C. Russillo; Alfredo Dubra; Thomas B. Connor, Jr; Dennis P. Han; Mark E. Pennesi; Christine N. Kay; David V. Weinberg; Kimberly E. Stepien; Joseph Carroll
Tags: photoreceptors, retinal cone, retinitis pigmentosa, usher syndrome, parafoveal region
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2428-2442. doi:https://doi.org/10.1167/iovs.15-18246
Autofluorescence Lifetimes in Geographic Atrophy in Patients With Age-Related Macular Degeneration Open Access
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Chantal Dysli; Sebastian Wolf; Martin S. Zinkernagel
Tags: atrophy, autofluorescence, fluorescence, age-related macular degeneration
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2479-2487. doi:https://doi.org/10.1167/iovs.15-18381
Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula Open Access
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Daniel Lavinsky; Jenny Wang; Philip Huie; Roopa Dalal; Seung Jun Lee; Dae Yeong Lee; Daniel Palanker
Tags: laser therapy, lasers, macula densa, macula lutea, rationale
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2488-2500. doi:https://doi.org/10.1167/iovs.15-18981
Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy Open Access
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Giuseppe Querques; Eliana Costanzo; Alexandra Miere; Vittorio Capuano; Eric H. Souied
Tags: atrophy, optical coherence tomography, atrophic condition of skin, eye, choroid
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2578-2582. doi:https://doi.org/10.1167/iovs.16-19083
Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology Open Access
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Katie M. Litts; Thomas Ach; Kristen M. Hammack; Kenneth R. Sloan; Yuhua Zhang; K. Bailey Freund; Christine A. Curcio
Tags: age-related macular degeneration, histology, optical coherence tomography, retinal cone, retina
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2647-2656. doi:https://doi.org/10.1167/iovs.16-19262
Progressive Early Breakdown of Retinal Pigment Epithelium Function in Hyperglycemic Rats Open Access
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Danielle M. Desjardins; Phil W. Yates; Mohammad Dahrouj; Yueying Liu; Craig E. Crosson; Zsolt Ablonczy
Tags: hyperglycemia, hyperglycemic agents, rats, vascular endothelial growth factor a, retinal pigment epithelium
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2706-2713. doi:https://doi.org/10.1167/iovs.15-18397
Frizzled3 Shapes the Development of Retinal Rod Bipolar Cells Open Access
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Ning Shen; Yibo Qu; Yankun Yu; Kwok-Fai So; Andre M. Goffinet; Noga Vardi; Ying Xu; Libing Zhou
Tags: retail clinics, retina, retinal bipolar cells, rod photoreceptors, dendrites
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2788-2796. doi:https://doi.org/10.1167/iovs.16-19281
Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats Open Access
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Biju B. Thomas; Danhong Zhu; Li Zhang; Padmaja B. Thomas; Yuntao Hu; Hossein Nazari; Francisco Stefanini; Paulo Falabella; Dennis O. Clegg; David R. Hinton; Mark S. Humayun
Tags: implants, polymers, rats, retinal pigment epithelium, transplantation
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2877-2887. doi:https://doi.org/10.1167/iovs.16-19238

Retinal Cell Biology

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses Open Access
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Kellie A. Schaefer; Marcus A. Toral; Gabriel Velez; Allison J. Cox; Sheila A. Baker; Nicholas C. Borcherding; Diana F. Colgan; Vimala Bondada; Charles B. Mashburn; Chen-Guang Yu; James W. Geddes; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
Tags: antibodies, calpain, photoreceptors, proteins, retina
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2509-2521. doi:https://doi.org/10.1167/iovs.15-18680
miR-124 Regulates Amadori-Glycated Albumin-Induced Retinal Microglial Activation and Inflammation by Targeting Rac1 Open Access
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Ning Dong; Bing Xu; Hong Shi; Yan Lu
Tags: albumins, inflammation, microglia, tumor necrosis factors, micrornas
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2522-2532. doi:https://doi.org/10.1167/iovs.15-18224
Increased Ocular Levels of MicroRNA-148a in Cases of Retinal Detachment Promote Epithelial–Mesenchymal Transition Open Access
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Kei Takayama; Hiroki Kaneko; Shiang-Jyi Hwang; Fuxiang Ye; Akiko Higuchi; Taichi Tsunekawa; Toshiyuki Matsuura; Takeshi Iwase; Tetsu Asami; Yasuki Ito; Shinji Ueno; Shunsuke Yasuda; Norie Nonobe; Hiroko Terasaki
Tags: micrornas, retinal detachment, epithelium, transfection
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2699-2705. doi:https://doi.org/10.1167/iovs.15-18660
Oxidative Stress-Induced Dysfunction of Müller Cells During Starvation Open Access
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Anne Katrine Toft-Kehler; Iswariaraja Scridevi Gurubaran; Claus Desler; Lene J. Rasmussen; Dorte Marie Skytt; Miriam Kolko
Tags: starvation, stress, glutamate, oxidative stress, pathophysiology
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2721-2728. doi:https://doi.org/10.1167/iovs.16-19275
Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2Akita/+ Murine Model of Diabetic Retinopathy Open Access
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Jing Wang; Xuezhi Cui; Penny Roon; Sylvia B. Smith
Tags: diabetes mellitus, diabetic retinopathy, mice, retinal degeneration, diabetes mellitus, type 2
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2770-2781. doi:https://doi.org/10.1167/iovs.15-18995
NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice Open Access
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Hongman Song; Camasamudram Vijayasarathy; Yong Zeng; Dario Marangoni; Ronald A. Bush; Zhijian Wu; Paul A. Sieving
Tags: mice, nadph oxidases, photoreceptors, retina, rod photoreceptors
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2864-2875. doi:https://doi.org/10.1167/iovs.15-18974

Visual Neuroscience

Increment Threshold Functions in Retinopathy of Prematurity Open Access
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Ronald M. Hansen; Anne Moskowitz; Jennifer N. Bush; Anne B. Fulton
Tags: retinopathy of prematurity, rod photoreceptors
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2421-2427. doi:https://doi.org/10.1167/iovs.16-19294
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response Open Access
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Corinne Kostic; Sylvain V. Crippa; Catherine Martin; Randy H. Kardon; Martin Biel; Yvan Arsenijevic; Aki Kawasaki
Tags: constriction procedure, mice, pupil, pupil reaction, retinal cone
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2501-2508. doi:https://doi.org/10.1167/iovs.16-19150

Review

The Effect of Statins on Intraocular Pressure and on the Incidence and Progression of Glaucoma: A Systematic Review and Meta-Analysis Open Access
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Paul McCann; Ruth E. Hogg; Richard Fallis; Augusto Azuara-Blanco
Tags: glaucoma, incidence, intraocular pressure, meta-analysis, statins
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2729-2748. doi:https://doi.org/10.1167/iovs.15-18595

Letters to the Editor

Lateral Sleep Position and Asymmetry in Glaucoma Open Access
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Chungkwon Yoo
Tags: glaucoma, sleep
Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2543-2544. doi:https://doi.org/10.1167/iovs.16-19187

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2400. doi:https://doi.org/10.1167/iovs.15-18769a
Erratum Open Access
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Investigative Ophthalmology & Visual Science May 2016, Vol.57, 2583. doi:https://doi.org/10.1167/iovs.15-17392a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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