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Editorial

Thank You to Our Reviewers Open Access
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Thomas Yorio
Tags: ophthalmology, peer review, vision
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2966. doi:https://doi.org/10.1167/iovs.16-19961

Research Highlight

Is Retinal Dopamine Involved in the Loss of Visual Function in Retinopathy of Prematurity? Open Access
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P. Michael Iuvone
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3380. doi:https://doi.org/10.1167/iovs.16-20073
Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation Open Access
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Daniel F. P. Larkin
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3485. doi:https://doi.org/10.1167/iovs.16-20027
Using Stem Cells to Rebuild the Outer Neural Retina Open Access
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Budd A. Tucker
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3521. doi:https://doi.org/10.1167/iovs.16-20098

Anatomy and Pathology/Oncology

Expression Profiling of Ascorbic Acid–Related Transporters in Human and Mouse Eyes Open Access
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Nan Ma; Carla Siegfried; Miyuki Kubota; Jie Huang; Ying Liu; Margaret Liu; Belinda Dana; Andrew Huang; David Beebe; Hong Yan; Ying-Bo Shui
Tags: ascorbic acid, eye, membrane transport proteins, mice, adams-stokes syndrome
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3440-3450. doi:https://doi.org/10.1167/iovs.16-19162

Clinical and Epidemiologic Research

Impact of Dry Eye Disease on Work Productivity, and Patients' Satisfaction With Over-the-Counter Dry Eye Treatments Open Access
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Kelly K. Nichols; Jason Bacharach; Edward Holland; Thomas Kislan; Lee Shettle; Orsolya Lunacsek; Barb Lennert; Caroline Burk; Vaishali Patel
Tags: drugs, non-prescription, dry eye syndromes, signs and symptoms, work productivity
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2975-2982. doi:https://doi.org/10.1167/iovs.16-19419
Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study Open Access
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Hélène Chan; Audrey Cougnard-Grégoire; Marie-Noëlle Delyfer; France Combillet; Marie-Bénédicte Rougier; Cédric Schweitzer; Jean-François Dartigues; Jean-François Korobelnik; Cécile Delcourt
Tags: diagnostic imaging, spectral domain-optical coherence tomography, fundus photography, drusen
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3058-3065. doi:https://doi.org/10.1167/iovs.16-19487

Cornea

Assessment of DNA Damage and Cell Senescence in Corneal Epithelial Cells Exposed to Airborne Particulate Matter (PM2.5) Collected in Guangzhou, China Open Access
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Zi-Xun Gao; Xi-Ling Song; Shan-Shan Li; Xiao-Rong Lai; Yu-Lan Yang; Guang Yang; Zhi-Jie Li; Yu-Hong Cui; Hong-Wei Pan
Tags: airborne particulate matter, cellular senescence, china, corneal epithelial cells, dna damage
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3093-3102. doi:https://doi.org/10.1167/iovs.15-18839
Measurement of an Elasticity Map in the Human Cornea Open Access
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Eric R. Mikula; James V. Jester; Tibor Juhasz
Tags: cornea, elasticity
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3282-3286. doi:https://doi.org/10.1167/iovs.15-18248
Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis Open Access
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Kyu-Yeon Han; Jin-Hong Chang; Hyun Lee; Dimitri T. Azar
Tags: angiogenesis, corneal neovascularization, endothelium, mice, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3313-3322. doi:https://doi.org/10.1167/iovs.16-19420
Coordinated Regulation of Palladin and α–Smooth Muscle Actin by Transforming Growth Factor–β in Human Corneal Fibroblasts Open Access
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Naoyuki Morishige; Shizuka Murata; Yoshikuni Nakamura; Haruya Azumi; Ryutaro Shin-gyou-uchi; Ken-Taro Oki; Yukiko Morita; Koh-Hei Sonoda
Tags: actins, cornea, fibroblasts, transforming growth factors, smooth muscle
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3360-3368. doi:https://doi.org/10.1167/iovs.15-18763
Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation Open Access
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Laura E. Downie; Janet Choi; Jeremiah K. H. Lim; Holly R. Chinnery
Tags: cornea, endothelial cells, keratitis, mice, personal integrity
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3477-3484. doi:https://doi.org/10.1167/iovs.15-19005

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Electrical Microstimulation of the Superior Colliculus in Strabismic Monkeys Open Access
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Jérome Fleuriet; Mark M. G. Walton; Seiji Ono; Michael J. Mustari
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3168-3180. doi:https://doi.org/10.1167/iovs.16-19488

Genetics

Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy Open Access
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Jwu Jin Khong; Kathryn P. Burdon; Yi Lu; Lefta Leonardos; Kate J. Laurie; John P. Walsh; Adam D. Gajdatsy; Peter R. Ebeling; Alan A. McNab; Thomas G. Hardy; Richard J. Stawell; Garry J. Davis; Dinesh Selva; Angelo Tsirbas; Grant W. Montgomery; Stuart Macgregor; Jamie E. Craig
Tags: cohort studies, genome-wide association study, genotype determination, polymorphism, thyroid
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3129-3137. doi:https://doi.org/10.1167/iovs.15-18797
Simultaneous Expression of ABCA4 and GPR143 Mutations: A Complex Phenotypic Manifestation Open Access
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Winston Lee; Kaspar Schuerch; Yajing Xie; Jana Zernant; Stephen H. Tsang; Janet R. Sparrow; Rando Allikmets
Tags: mutation, phenotype, family, eye, diagnostic imaging
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3409-3415. doi:https://doi.org/10.1167/iovs.16-19621
Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma Open Access
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Soo Khai Ng; Kathryn P. Burdon; Jude T. Fitzgerald; Tiger Zhou; Rhys Fogarty; Emmanuelle Souzeau; John Landers; Richard A. Mills; Robert J. Casson; Bronwyn Ridge; Stuart L. Graham; Alex W. Hewitt; David A. Mackey; Paul R. Healey; Jie Jin Wang; Paul Mitchell; Stuart MacGregor; Jamie E. Craig
Tags: 9p21 nucleotide sequence, genetics, glaucoma, low tension glaucoma, open-angle glaucoma
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3416-3421. doi:https://doi.org/10.1167/iovs.16-19401
AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo Open Access
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Sandy S. C. Hung; Vicki Chrysostomou; Fan Li; Jeremiah K. H. Lim; Jiang-Hui Wang; Joseph E. Powell; Leilei Tu; Maciej Daniszewski; Camden Lo; Raymond C. Wong; Jonathan G. Crowston; Alice Pébay; Anna E. King; Bang V. Bui; Guei-Sheung Liu; Alex W. Hewitt
Tags: crispr, genes, retina, mice, eye
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3470-3476. doi:https://doi.org/10.1167/iovs.16-19316

Glaucoma

In Vivo Goblet Cell Density as a Potential Indicator of Glaucoma Filtration Surgery Outcome Open Access
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Luca Agnifili; Vincenzo Fasanella; Rodolfo Mastropasqua; Paolo Frezzotti; Claudia Curcio; Lorenza Brescia; Giorgio Marchini
Tags: filtering surgery, glaucoma, goblet cells, conjunctiva, blister
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2928-2935. doi:https://doi.org/10.1167/iovs.16-19257
Spectral-Domain Optical Coherence Tomography Features in Open-Angle Glaucoma With Diabetes Mellitus and Inadequate Glycemic Control Open Access
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So Yeon Jeong; Sang Jun Park; Hee Seung Chin; So Hun Kim; Na Rae Kim
Tags: diabetes mellitus, eye, glaucoma, glycemic control, open-angle glaucoma
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3024-3031. doi:https://doi.org/10.1167/iovs.16-19457R1
Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Photopic Contrast Sensitivity in Mice Open Access
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Meike E. van der Heijden; Priya Shah; Cameron S. Cowan; Zhuo Yang; Samuel M. Wu; Benjamin J. Frankfort
Tags: contrast sensitivity, intraocular pressure, mice, injections, eye
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3077-3087. doi:https://doi.org/10.1167/iovs.16-19312
Beta and Gamma Peripapillary Atrophy in Myopic Eyes With and Without Glaucoma Open Access
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Jayme R. Vianna; Rizwan Malik; Vishva M. Danthurebandara; Glen P. Sharpe; Anne C. Belliveau; Lesya M. Shuba; Balwantray C. Chauhan; Marcelo T. Nicolela
Tags: atrophy, eye, glaucoma, optic disk
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3103-3111. doi:https://doi.org/10.1167/iovs.16-19646
Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure–Function Relationship in Glaucoma Open Access
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Yuri Fujino; Takehiro Yamashita; Hiroshi Murata; Ryo Asaoka
Tags: central retinal artery, glaucoma
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3152-3158. doi:https://doi.org/10.1167/iovs.16-19461
Three-Dimensional Segmentation and Quantitative Measurement of the Aqueous Outflow System of Intact Mouse Eyes Based on Spectral Two-Photon Microscopy Techniques Open Access
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Xianzeng Zhang; Nenrong Liu; Peng Un Mak; Sio Hang Pun; Mang I. Vai; Omid Masihzadeh; Malik Y. Kahook; Tim C. Lei; David A. Ammar
Tags: aneurysms-osteoarthritis syndrome, apraxia of speech, diagnostic imaging, eye, mice
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3159-3167. doi:https://doi.org/10.1167/iovs.15-18491
Clustering of Combined 24-2 and 10-2 Visual Field Grids and Their Relationship With Circumpapillary Retinal Nerve Fiber Layer Thickness Open Access
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Hideo Nakanishi; Tadamichi Akagi; Kenji Suda; Tomoko Hasegawa; Hiroshi Yamada; Satoshi Yokota; Munemitsu Yoshikawa; Yuto Iida; Hanako Ohashi Ikeda; Satoshi Morooka; Kenji Ishihara; Nagahisa Yoshimura
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3203-3210. doi:https://doi.org/10.1167/iovs.15-18798
Estimating the Binocular Visual Field of Glaucoma Patients With an Adjustment for Ocular Dominance Open Access
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Masato Matsuura; Kazunori Hirasawa; Mieko Yanagisawa; Hiroyo Hirasawa; Hiroshi Murata; Hiromasa Sawamura; Chihiro Mayama; Ryo Asaoka
Tags: glaucoma, ocular dominance, visual fields, eye, summation
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3276-3281. doi:https://doi.org/10.1167/iovs.15-19024
Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model Open Access
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Sally Miller; Emma Leishman; Sherry Shujung Hu; Alhasan Elghouche; Laura Daily; Natalia Murataeva; Heather Bradshaw; Alex Straiker
Tags: endocannabinoids, eye, intraocular pressure, mice
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3287-3296. doi:https://doi.org/10.1167/iovs.16-19356
Quantitative Measurements of the Ciliary Body in Eyes With Acute Primary-Angle Closure Open Access
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Zhonghao Wang; Chuchen Chung; Jialiu Lin; Jianan Xu; Jingjing Huang
Tags: ciliary body, eye, ultrasound biomicroscopy
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3299-3305. doi:https://doi.org/10.1167/iovs.16-19558
Displacement of the Lamina Cribrosa in Response to Acute Intraocular Pressure Elevation in Normal Individuals of African and European Descent Open Access
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Massimo A. Fazio; John K. Johnstone; Brandon Smith; Lan Wang; Christopher A. Girkin
Tags: cribriform plate, intraocular pressure, optic disk, racial differences, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3331-3339. doi:https://doi.org/10.1167/iovs.15-17940
Patients With Intravitreal Gas Bubbles at Risk of High Intraocular Pressure Without Exceeding Elevation of Surgery: Theoretical Analysis Open Access
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Lucas Gsellman; Rouzbeh Amini
Tags: intraocular pressure, surgical procedures, operative, travel, vitrectomy, high altitude
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3340-3347. doi:https://doi.org/10.1167/iovs.15-18010
Epigenetic Modification Prevents Excessive Wound Healing and Scar Formation After Glaucoma Filtration Surgery Open Access
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Ajay Sharma; Govindaraj Anumanthan; Marcos Reyes; Huiyi Chen; Jacob W. Brubaker; Saad Siddiqui; Suneel Gupta; Frank G. Rieger; Rajiv R. Mohan
Tags: blister, cicatrix, epigenetics, filtering surgery, glaucoma
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3381-3389. doi:https://doi.org/10.1167/iovs.15-18750
Lamina Cribrosa Microarchitecture in Monkey Early Experimental Glaucoma: Global Change Open Access
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Juan Reynaud; Howard Lockwood; Stuart K. Gardiner; Galen Williams; Hongli Yang; Claude F. Burgoyne
Tags: cercopithecidae, cribriform plate, eye, glaucoma, intraocular pressure
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3451-3469. doi:https://doi.org/10.1167/iovs.16-19474

Lens

Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization Open Access
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Eddie Wang; Andrew Geng; Ankur M. Maniar; Byron W. H. Mui; Xiaohua Gong
Tags: gap junction protein, lens (device), lens, crystalline, actins
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3039-3046. doi:https://doi.org/10.1167/iovs.16-19521
The Phosphoinosotide 3-Kinase Catalytic Subunit p110α is Required for Normal Lens Growth Open Access
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Caterina Sellitto; Leping Li; Ehsan Vaghefi; Paul J. Donaldson; Richard Z. Lin; Thomas W. White
Tags: catalytic domain, lens (device), lens, crystalline, phosphotransferases, mice
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3145-3151. doi:https://doi.org/10.1167/iovs.16-19607

Low Vision

Illness Cognitions and Coping Self-Efficacy in Depression Among Persons With Low Vision Open Access
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Bonnie A. Sturrock; Jing Xie; Edith E. Holloway; Mark Hegel; Robin Casten; David Mellor; Eva Fenwick; Gwyneth Rees
Tags: cognition, coping behavior, depressive disorders, self efficacy, visual impairment
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3032-3038. doi:https://doi.org/10.1167/iovs.16-19110
Clustering of Eye Fixations: A New Oculomotor Determinant of Reading Speed in Maculopathy Open Access
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Aurélie Calabrèse; Jean-Baptiste Bernard; Géraldine Faure; Louis Hoffart; Eric Castet
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3192-3202. doi:https://doi.org/10.1167/iovs.16-19318

Multidisciplinary Ophthalmic Imaging

Evaluating Descriptive Metrics of the Human Cone Mosaic Open Access
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Robert F. Cooper; Melissa A. Wilk; Sergey Tarima; Joseph Carroll
Tags: mosaicism, retinal cone
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2992-3001. doi:https://doi.org/10.1167/iovs.16-19072
Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk Open Access
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Bo Wang; Katie A. Lucy; Joel S. Schuman; Ian A. Sigal; Richard A. Bilonick; Larry Kagemann; Tigran Kostanyan; Chen Lu; Jonathan Liu; Ireneusz Grulkowski; James G. Fujimoto; Hiroshi Ishikawa; Gadi Wollstein
Tags: cribriform plate, diameter, eye, glaucoma, retinal vessels
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3088-3092. doi:https://doi.org/10.1167/iovs.15-19010

Nantotechnology and Regenerative Medicine

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye Open Access
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Fang Bian; Crystal S. Shin; Changjun Wang; Stephen C. Pflugfelder; Ghanashyam Acharya; Cintia S. De Paiva
Tags: alkalies, burns, cornea, dexamethasone, dry eye syndromes
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3222-3230. doi:https://doi.org/10.1167/iovs.16-19074
Generation of Retinal Ganglion Cells With Functional Axons From Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells Open Access
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Taku Tanaka; Tadashi Yokoi; Fuminobu Tamalu; Shu-Ichi Watanabe; Sachiko Nishina; Noriyuki Azuma
Tags: axon, embryonic stem cells, mice, pluripotent stem cells, retinal ganglion cells
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3348-3359. doi:https://doi.org/10.1167/iovs.16-19166

Physiology and Pharmacology

Blockage of PI3K/mTOR Pathways Inhibits Laser-Induced Choroidal Neovascularization and Improves Outcomes Relative to VEGF-A Suppression Alone Open Access
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Jie Ma; Yu Sun; Francisco J. López; Peter Adamson; Edit Kurali; Kameran Lashkari
Tags: 1-phosphatidylinositol 3-kinase, aflibercept, choroidal neovascularization, lasers, mtor serine-threonine kinases
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3138-3144. doi:https://doi.org/10.1167/iovs.15-18795
Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content Open Access
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Hideki Miyake; Tomoko Oda; Osamu Katsuta; Masaharu Seno; Masatsugu Nakamura
Tags: diet, lipids, meibomian gland, mice, inbred hrs, pathophysiology
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3268-3275. doi:https://doi.org/10.1167/iovs.16-19227
Factors Determining Flicker-Induced Retinal Vasodilation in Healthy Subjects Open Access
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Mozhgan Sharifizad; Katarzyna J. Witkowska; Gerold C. Aschinger; Sabina Sapeta; Alexandra Rauch; Doreen Schmidl; Rene M. Werkmeister; Gerhard Garhöfer; Leopold Schmetterer
Tags: photopsia, vasodilation
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3306-3312. doi:https://doi.org/10.1167/iovs.16-19261

Retina

Evaluation of Retinal Circulation Using Segmental-Scanning Doppler Optical Coherence Tomography in Anesthetized Cats Open Access
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Taiji Nagaoka; Tomofumi Tani; Young-Seok Song; Takafumi Yoshioka; Akihiro Ishibazawa; Seigo Nakabayashi; Masahiro Akiba; Akitoshi Yoshida
Tags: adaptive testing, cats, optical coherence tomography, retina circulation, velocity
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2936-2941. doi:https://doi.org/10.1167/iovs.15-18303
Association of Plasma Semaphorin 3A With Phenotypes of Diabetic Retinopathy and Nephropathy Open Access
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Soo Hyun Kwon; Jae Pil Shin; In Taek Kim; Dong Ho Park
Tags: albuminuria, diabetic retinopathy, plasma, semaphorin-3a, kidney diseases
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2983-2989. doi:https://doi.org/10.1167/iovs.16-19468
Safety and Feasibility of Quantitative Multiplexed Cytokine Analysis From Office-Based Vitreous Aspiration Open Access
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Devon H. Ghodasra; Ryan Fante; Thomas W. Gardner; Michael Langue; Leslie M. Niziol; Cagri Besirli; Steven R. Cohen; Vaidehi S. Dedania; Hakan Demirci; Nieraj Jain; K. Thiran Jayasundera; Mark W. Johnson; Partho S. Kalyani; Rajesh C. Rao; David N. Zacks; Jeffrey M. Sundstrom
Tags: aspirations (psychology), cytokine, pulmonary aspiration, safety, vitreous body
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3017-3023. doi:https://doi.org/10.1167/iovs.15-18721
Epithelial Membrane Protein-2 in Human Proliferative Vitreoretinopathy and Epiretinal Membranes Open Access
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David G. Telander; Alfred K. Yu; Krisztina I. Forward; Shawn A. Morales; Lawrence S. Morse; Susanna S. Park; Lynn K. Gordon
Tags: epiretinal membrane, epithelium, proteins, tissue membrane, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3112-3117. doi:https://doi.org/10.1167/iovs.15-17791
Automated Light- and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa: Filling a Need to Accommodate Multicenter Clinical Trials Open Access
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David B. McGuigan, III; Alejandro J. Roman; Artur V. Cideciyan; Rodrigo Matsui; Michaela L. Gruzensky; Rebecca Sheplock; Samuel G. Jacobson
Tags: perimetry, retinal cone, retinitis pigmentosa, rod photoreceptors, visual fields
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3118-3128. doi:https://doi.org/10.1167/iovs.16-19302
Spatial Restriction of Neural Activation Using Focused Multipolar Stimulation With a Retinal Prosthesis Open Access
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Thomas C. Spencer; James B. Fallon; Patrick C. Thien; Mohit N. Shivdasani
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3181-3191. doi:https://doi.org/10.1167/iovs.16-19325
Developing an Outcome Measure With High Luminance for Optogenetics Treatment of Severe Retinal Degenerations and for Gene Therapy of Cone Diseases Open Access
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Artur V. Cideciyan; Alejandro J. Roman; Samuel G. Jacobson; Boyuan Yan; Michele Pascolini; Jason Charng; Simone Pajaro; Sheila Nirenberg
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3211-3221. doi:https://doi.org/10.1167/iovs.16-19586
Early Detection of Amyloidopathy in Alzheimer's Mice by Hyperspectral Endoscopy Open Access
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Swati S. More; James M. Beach; Robert Vince
Tags: alzheimer's disease, diagnostic imaging, early diagnosis, endoscopy, mice
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3231-3238. doi:https://doi.org/10.1167/iovs.15-17406
Frequency, Phenotypic Characteristics and Progression of Atrophy Associated With a Diseased Bruch's Membrane in Pseudoxanthoma Elasticum Open Access
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Martin Gliem; Philipp L. Müller; Johannes Birtel; Doris Hendig; Frank G. Holz; Peter Charbel Issa
Tags: atrophy, bruch's basal membrane, phenotype, pseudoxanthoma elasticum
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3323-3330. doi:https://doi.org/10.1167/iovs.16-19388
In Vivo Fluorescence Retinal Imaging Following AAV2-Mediated Gene Delivery in the Rat Retina Open Access
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Joo Yong Lee; Yoonha Hwang; Ji Hyun Kim; Yu Sun Kim; Bok Kyoung Jung; Pilhan Kim; Heuiran Lee
Tags: diagnostic imaging, fluorescence, genes, intravitreal injections, retina
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3390-3396. doi:https://doi.org/10.1167/iovs.15-18862
Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1 Open Access
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John M. Nolan; Rebecca Power; Jim Stringham; Jessica Dennison; Jim Stack; David Kelly; Rachel Moran; Kwadwo O. Akuffo; Laura Corcoran; Stephen Beatty
Tags: carotenoids, contrast sensitivity, macular pigment, placebos, retinal diseases
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3429-3439. doi:https://doi.org/10.1167/iovs.16-19520
Retinal Pigment Epithelium Responses to Selective Retina Therapy in Mouse Eyes Open Access
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Hoon Dong Kim; Sun Young Jang; Si Hyung Lee; Young Shin Kim; Young-Hoon Ohn; Ralf Brinkmann; Tae Kwann Park
Tags: cell death, eye, lasers, mice, mitf protein
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3486-3495. doi:https://doi.org/10.1167/iovs.16-19508
Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy Open Access
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Tiago Santos-Ferreira; Manuela Völkner; Oliver Borsch; Jochen Haas; Peter Cimalla; Praveen Vasudevan; Peter Carmeliet; Denis Corbeil; Stylianos Michalakis; Edmund Koch; Mike O. Karl; Marius Ader
Tags: meckel-gruber syndrome, mice, photoreceptors, rod photoreceptors, transplantation
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3509-3520. doi:https://doi.org/10.1167/iovs.16-19087
Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats Open Access
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Steven Roth; John C. Dreixler; Biji Mathew; Irina Balyasnikova; Jacob R. Mann; Venkat Boddapati; Lai Xue; Maciej S. Lesniak
Tags: hypoxia, retinal ischemia, stem cells, rats, bone marrow
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3522-3532. doi:https://doi.org/10.1167/iovs.15-17381

Retinal Cell Biology

Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function Open Access
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Lauren L. Daniele; Farida Emran; Glenn P. Lobo; Robert J. Gaivin; Brian D. Perkins
Tags: larva, mutation, photoreceptors, proteins, synapses
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2942-2954. doi:https://doi.org/10.1167/iovs.15-18996
Involvement of IL-37 in the Pathogenesis of Proliferative Diabetic Retinopathy Open Access
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Mengmeng Zhao; Yongguang Hu; Ying Yu; Qing Lin; Jianhua Yang; Shao Bo Su; Guo-Tong Xu; Tianshu Yang
Tags: cell proliferation, enzyme-linked immunosorbent assay, interleukins, pathogenesis, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2955-2962. doi:https://doi.org/10.1167/iovs.15-18505
Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy Open Access
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David Gersztenkorn; Ciro Coletta; Shuang Zhu; Yonju Ha; Hua Liu; Hongyan Tie; Jia Zhou; Csaba Szabo; Wenbo Zhang; Massoud Motamedi
Tags: hydrogen sulfide, ischemia, oxygen, retina, retinal diseases
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3002-3009. doi:https://doi.org/10.1167/iovs.15-18555
Vulnerability of Dopaminergic Amacrine Cells to Chronic Ischemia in a Mouse Model of Oxygen-Induced Retinopathy Open Access
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Nathan J. Spix; Lei-Lei Liu; Zhijing Zhang; Joshua P. Hohlbein; Cameron L. Prigge; Shravan Chintala; Christophe P. Ribelayga; Dao-Qi Zhang
Tags: amacrine cells, dopamine, ischemia, mice, oxygen
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3047-3057. doi:https://doi.org/10.1167/iovs.16-19346
VEGF as a Survival Factor in Ex Vivo Models of Early Diabetic Retinopathy Open Access
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Rosario Amato; Martina Biagioni; Maurizio Cammalleri; Massimo Dal Monte; Giovanni Casini
Tags: prognostic factors, vascular endothelial growth factor a, diabetic retinopathy, pituitary adenylate cyclase activating polypeptide
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3066-3076. doi:https://doi.org/10.1167/iovs.16-19285
Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4−/−Rdh8−/− Mice After Light Exposure Open Access
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Tanu Parmar; Vipul M. Parmar; Eisuke Arai; Bhubanananda Sahu; Lindsay Perusek; Akiko Maeda
Tags: lcn2 gene, light exposure, mice, proteins, retinal degeneration
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3257-3267. doi:https://doi.org/10.1167/iovs.15-18993
Beneficial Effects of Berberine on Oxidized LDL-Induced Cytotoxicity to Human Retinal Müller Cells Open Access
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Dongxu Fu; Jeremy Y. Yu; Anna R. Connell; Shihe Yang; Michelle B. Hookham; Rebecca McLeese; Timothy J. Lyons
Tags: berberine, low-density lipoproteins, suidae, cytotoxicity
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3369-3379. doi:https://doi.org/10.1167/iovs.16-19291
Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina Open Access
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Xinyi Su; Queenie S. W. Tan; Bhav H. Parikh; Alison Tan; Milan N. Mehta; Yeo Sia Wey; Sai Bo Bo Tun; Ling-Jun Li; Xiao-Yan Han; Tien Y. Wong; Walter Hunziker; Chi D. Luu; Yuji Owada; Veluchamy A. Barathi; Samuel S. Zhang; Shyam S. Chaurasia
Tags: fatty acid-binding proteins, mice, retina
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3397-3408. doi:https://doi.org/10.1167/iovs.15-18542

Visual Neuroscience

A Preliminary Study on Normalized Pattern-Reversal Peripheral Field SSVEPs as a Potential Objective Indicator of Useful Field of View Performance Open Access
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Sheng Tong Lin; Lian Kheng Tey
Tags: attention, linear regression, psychophysics, regression analysis, sample size
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3248-3256. doi:https://doi.org/10.1167/iovs.15-18439
Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse Retina Open Access
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Matthew J. Tarchick; Parastoo Bassiri; Rebecca M. Rohwer; Ivy S. Samuels
Tags: diabetes mellitus, mice, retina, electroretinography, streptozocin
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3496-3508. doi:https://doi.org/10.1167/iovs.15-18775

Visual Psychophysics and Physiological Optics

Influence of Ametropia and Its Correction on Measurement of Accommodation Open Access
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Paula Bernal-Molina; Fernando Vargas-Martín; Larry N. Thibos; Norberto López-Gil
Tags: eye, refractive errors, visual accommodation, cornea, lens, crystalline
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3010-3016. doi:https://doi.org/10.1167/iovs.15-18686
Effects of Intraocular Lens Opacification on Light Scatter, Stray Light, and Overall Optical Quality/Performance Open Access
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Liliana Werner; John C. Stover; Jim Schwiegerling; Kamal K. Das
Tags: intraocular lens implant device, lens (device), lens, crystalline, opacification, optics
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3239-3247. doi:https://doi.org/10.1167/iovs.16-19514
Mirror Symmetry of Peripheral Monochromatic Aberrations in Fellow Eyes of Isomyopes and Anisomyopes Open Access
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Uchechukwu L. Osuagwu; Marwan Suheimat; David A. Atchison
Tags: eye, visual fields
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3422-3428. doi:https://doi.org/10.1167/iovs.16-19267

Letters to the Editor

Comments on Macular Choroidal Thickness in Children: The Shandong Children Eye Study Open Access
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Brijesh Takkar; Karthikeya R; Shorya Azad
Tags: child, eye
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2963. doi:https://doi.org/10.1167/iovs.15-18984
Author Response: Comments on Macular Choroidal Thickness in Children: The Shandong Children Eye Study Open Access
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Juan Mei Zhang; Jian Feng Wu; Jian Hua Chen; Ling Wang; Tai Liang Lu; Wei Sun; Yuan Yuan Hu; Wen Jun Jiang; Da Dong Guo; Xing Rong Wang; Hong Sheng Bi; Jost B. Jonas
Tags: child, eye
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2964-2965. doi:https://doi.org/10.1167/iovs.16-19211
Motion Responses in Human Strabismus: What Optokinesis in the Deviating Eye Is Telling Us Open Access
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Michael C. Brodsky
Tags: eye, motion, strabismus
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2990. doi:https://doi.org/10.1167/iovs.16-19569
Author Response: Motion Responses in Human Strabismus: What Optokinesis in the Deviating Eye Is Telling Us Open Access
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Sevda Agaoglu; Mehmet N. Agaoglu; Vallabh E. Das
Tags: eye, motion, strabismus
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2991. doi:https://doi.org/10.1167/iovs.16-19774
Quantitative Autofluorescence and ABCA4 Disease Open Access
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Rando Allikmets; Tobias Duncker; Winston Lee; Stephen H. Tsang
Tags: autofluorescence
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 3297-3298. doi:https://doi.org/10.1167/iovs.16-19342

Index

Reviewers Open Access
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Tags: acetylcholine, achondroplasia, antineutrophil cytoplasmic autoantibody, arthritis, juvenile rheumatoid, barrett's esophagus
Investigative Ophthalmology & Visual Science June 2016, Vol.57, 2967-2974. doi:https://doi.org/10.1167/iovs.16-19828
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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