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Research Highlight

New Insight Into the Protrusions and Paddles That Link Lens Fiber Cells Open Access
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A. Sue Menko
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4100. doi:https://doi.org/10.1167/iovs.16-20340

Anatomy and Pathology/Oncology

Intraocular Metastases Secondary to Breast Carcinoma Correlates With Upregulation of Estrogen and Progesterone Receptor Expression in the Primary Tumor Open Access
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Raffaele Parrozzani; Luisa Frizziero; Ilaria Testi; Giacomo Miglionico; Pierdavide Perrini; Serena Pulze; Elisabetta Pilotto; Edoardo Midena
Tags: breast carcinoma, estrogen, neoplasm metastasis, neoplasms, receptors, progesterone
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3944-3948. doi:https://doi.org/10.1167/iovs.16-19695
The Effects of the Relative Strength of Simultaneous Competing Defocus Signals on Emmetropization in Infant Rhesus Monkeys Open Access
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Baskar Arumugam; Li-Fang Hung; Chi-Ho To; Padmaja Sankaridurg; Earl L. Smith III
Tags: cercopithecidae, country of poland, eye, infant, lens (device)
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3949-3960. doi:https://doi.org/10.1167/iovs.16-19704
Pemphigus Autoantibodies Induce Blistering in Human Conjunctiva Open Access
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Franziska Vielmuth; Vera Rötzer; Eva Hartlieb; Christoph Hirneiß; Jens Waschke; Volker Spindler
Tags: autoantibodies, blister, conjunctiva, pemphigus, pemphigus vulgaris
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4442-4449. doi:https://doi.org/10.1167/iovs.16-19582

Biochemistry and Molecular Biology

Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of Graves' Orbitopathy Open Access
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Sun Young Jang; Min Kyung Chae; Joon H. Lee; Eun Jig Lee; Jin Sook Yoon
Tags: fibroblasts, inflammation, interleukin-6, proteins, regulation
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4027-4034. doi:https://doi.org/10.1167/iovs.16-19213
Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy Open Access
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Jung Woo Byun; Sena Hwang; Chan Woo Kang; Jin Hee Kim; Min Kyung Chae; Jin Sook Yoon; Eun Jig Lee
Tags: aldehydes, fibroblasts, hyaluronan, tumor necrosis factors, western blotting
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4055-4062. doi:https://doi.org/10.1167/iovs.15-19037

Clinical and Epidemiologic Research

Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population Open Access
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Nisha S. Yeotikar; Hua Zhu; Maria Markoulli; Kelly K. Nichols; Thomas Naduvilath; Eric B. Papas
Tags: adult, dry eye syndromes, eye, lipids, meibomian gland
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3996-4007. doi:https://doi.org/10.1167/iovs.15-18467

Cornea

Analysis of Factors Associated With the Tear Film Lipid Layer Thickness in Normal Eyes and Patients With Dry Eye Syndrome Open Access
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Ji Won Jung; Si Yoon Park; Jin Sun Kim; Eung Kweon Kim; Kyoung Yul Seo; Tae-im Kim
Tags: dry eye syndromes, eye, lipids, tear film finding, meibomian gland
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4076-4083. doi:https://doi.org/10.1167/iovs.16-19251
Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression Open Access
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Duk-Won D. Chung; Ricardo F. Frausto; Stephan Chiu; Benjamin R. Lin; Anthony J. Aldave
Tags: binding (molecular function), collagen, e-cadherin, luciferases, promoter regions (genetics)
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4136-4143. doi:https://doi.org/10.1167/iovs.16-19533
Intraocular Pressure Changes and Relationship With Corneal Biomechanics After SMILE and FS-LASIK Open Access
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Hua Li; Yan Wang; Rui Dou; Pinghui Wei; Jiamei Zhang; Wei Zhao; Liuyang Li
Tags: biomechanics, cornea, intraocular pressure, keratomileusis, laser in situ, surgical procedures, operative
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4180-4186. doi:https://doi.org/10.1167/iovs.16-19615
Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells? Open Access
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Wendy R. Kam; Yang Liu; Juan Ding; David A. Sullivan
Tags: bimatoprost, cyclosporine, epithelial cells, interleukin-1 receptor antagonists, meibomian gland
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4287-4294. doi:https://doi.org/10.1167/iovs.16-19937
Gene Signature–Based Development of ELISA Assays for Reproducible Qualification of Cultured Human Corneal Endothelial Cells Open Access
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Morio Ueno; Kazuko Asada; Munetoyo Toda; Ursula Schlötzer-Schrehardt; Kazue Nagata; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: cornea, cytokine, endothelial cells, enzyme-linked immunosorbent assay, gene expression profiling
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4295-4305. doi:https://doi.org/10.1167/iovs.16-19806
Cultured Human Corneal Endothelial Cell Aneuploidy Dependence on the Presence of Heterogeneous Subpopulations With Distinct Differentiation Phenotypes Open Access
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Junji Hamuro; Morio Ueno; Munetoyo Toda; Chie Sotozono; Monty Montoya; Shigeru Kinoshita
Tags: aneuploidy, cornea, karyotype determination procedure, phenotype, endothelial cells
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4385-4392. doi:https://doi.org/10.1167/iovs.16-19771
Concomitant Evaluation of a Panel of Exosome Proteins and MiRs for Qualification of Cultured Human Corneal Endothelial Cells Open Access
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Morio Ueno; Kazuko Asada; Munetoyo Toda; Kazue Nagata; Chie Sotozono; Nobuyoshi Kosaka; Takahiro Ochiya; Shigeru Kinoshita; Junji Hamuro
Tags: cd44 antigens, cornea, endothelial cells, exosomes, homing-associated cell adhesion molecule
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4393-4402. doi:https://doi.org/10.1167/iovs.16-19805
Metabolic Plasticity in Cell State Homeostasis and Differentiation of Cultured Human Corneal Endothelial Cells Open Access
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Junji Hamuro; Morio Ueno; Kazuko Asada; Munetoyo Toda; Monty Montoya; Chie Sotozono; Shigeru Kinoshita
Tags: cd44 antigens, cornea, endothelial cells, glucose, homeostasis
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4452-4463. doi:https://doi.org/10.1167/iovs.16-19807

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Perceived Visual Distortions in Juvenile Amblyopes During/Following Routine Amblyopia Treatment Open Access
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Marianne E. F. Piano; Peter J. Bex; Anita J. Simmers
Tags: amblyopia, child
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4045-4054. doi:https://doi.org/10.1167/iovs.16-19210
Perceptual Learning in Children With Infantile Nystagmus: Effects on Visual Performance Open Access
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Bianca Huurneman; F. Nienke Boonstra; Jeroen Goossens
Tags: child, crowding, pathologic nystagmus, perceptual learning, training
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4216-4228. doi:https://doi.org/10.1167/iovs.16-19554
Perceptual Learning in Children With Infantile Nystagmus: Effects on 2D Oculomotor Behavior Open Access
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Bianca Huurneman; F. Nienke Boonstra; Jeroen Goossens
Tags: child, pathologic nystagmus, saccades, training, perceptual learning
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4229-4238. doi:https://doi.org/10.1167/iovs.16-19555
Perceptual Learning in Children With Infantile Nystagmus: Effects on Reading Performance Open Access
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Bianca Huurneman; F. Nienke Boonstra; Jeroen Goossens
Tags: child, reading (activity), training, pathologic nystagmus, perceptual learning
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4239-4246. doi:https://doi.org/10.1167/iovs.16-19556
Stereoscopic Viewing Can Induce Changes in the CA/C Ratio Open Access
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Pascaline Neveu; Corinne Roumes; Matthieu Philippe; Philippe Fuchs; Anne-Emmanuelle Priot
Tags: visual accommodation
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4321-4326. doi:https://doi.org/10.1167/iovs.15-18854
In Vivo Morphology of the Optic Nerve and Retina in Patients With Parkinson's Disease Open Access
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Anastasia Pilat; Rebecca J. McLean; Frank A. Proudlock; Gail D. E. Maconachie; Viral Sheth; Yusuf A. Rajabally; Irene Gottlob
Tags: language morphology, morphology, optic disk, optic nerve, parkinson disease
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4420-4427. doi:https://doi.org/10.1167/iovs.16-20020
Exploring the Divergence Range for Stereopsis Maintenance With a Computer-Simulated Troposcope in Patients With Intermittent Exotropia Open Access
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Chu-Hsuan Huang; Ai-Hou Wang; Fung-Rong Hu; Tzu-Hsun Tsai
Tags: computers, depth perception, intermittent exotropia, eye
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4493-4497. doi:https://doi.org/10.1167/iovs.16-19779

Genetics

MicroRNA Expression Profile in Conjunctival Melanoma Open Access
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Ann-Cathrine Larsen; Lauge H. Mikkelsen; Rehannah Borup; Katalin Kiss; Peter B. Toft; Christian von Buchwald; Sarah E. Coupland; Jan U. Prause; Steffen Heegaard
Tags: malignant melanoma of conjunctiva, micrornas, neoplasms, melanoma
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4205-4212. doi:https://doi.org/10.1167/iovs.16-19862
Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone–Rod Dystrophy Open Access
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Akiko Suga; Atsushi Mizota; Mitsuhiro Kato; Kazuki Kuniyoshi; Kazutoshi Yoshitake; William Sultan; Masashi Yamazaki; Yoshikazu Shimomura; Kazuho Ikeo; Kazushige Tsunoda; Takeshi Iwata
Tags: japanese, mutation, proteins, retinitis pigmentosa, photoreceptors
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4255-4263. doi:https://doi.org/10.1167/iovs.16-19450
A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium Open Access
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Yutao Liu; Jessica Cooke Bailey; Inas Helwa; W. Michael Dismuke; Jingwen Cai; Michelle Drewry; Murray H. Brilliant; Donald L. Budenz; William G. Christen; Daniel I. Chasman; John H. Fingert; Douglas Gaasterland; Terry Gaasterland; Mae O. Gordon; Robert P. Igo, Jr; Jae H. Kang; Michael A. Kass; Peter Kraft; Richard K. Lee; Paul Lichter; Sayoko E. Moroi; Anthony Realini; Julia E. Richards; Robert Ritch; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Yeunjoo E. Song; Douglas Vollrath; Robert Weinreb; Felipe Medeiros; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret A. Pericak-Vance; Pedro Gonzalez; W. Daniel Stamer; John Kuchtey; Rachel W. Kuchtey; R. Rand Allingham; Michael A. Hauser; Louis R. Pasquale; Jonathan L. Haines; Janey L. Wiggs
Tags: micrornas, neighborhood, open-angle glaucoma, glaucoma, body tissue
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4528-4535. doi:https://doi.org/10.1167/iovs.16-19688

Glaucoma

Characteristics of Retinal Nerve Fiber Layer Defect in Nonglaucomatous Eyes With Type II Diabetes Open Access
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Soo Ji Jeon; Jin-Woo Kwon; Tae Yoon La; Chan Kee Park; Jin A Choi
Tags: diabetes mellitus, type 2, eye, glaucoma, nerve degeneration
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4008-4015. doi:https://doi.org/10.1167/iovs.16-19525
Increased Frataxin Levels Protect Retinal Ganglion Cells After Acute Ischemia/Reperfusion in the Mouse Retina In Vivo Open Access
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Rowena Schultz; Otto W. Witte; Christian Schmeer
Tags: acute ischemia, ischemia, mice, neuroprotection, physiologic reperfusion
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4115-4124. doi:https://doi.org/10.1167/iovs.16-19260
In Vivo Identification of the Posttrabecular Aqueous Outflow Pathway Using Swept-Source Optical Coherence Tomography Open Access
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Akihito Uji; Yuki Muraoka; Nagahisa Yoshimura
Tags: diagnostic imaging, optical coherence tomography, sclera, face
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4162-4169. doi:https://doi.org/10.1167/iovs.16-19869
Effect of Glaucoma Surgery on the Progression Rate and Pattern in Glaucoma Patients With Myopia Open Access
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Hae-Young Lopilly Park; Rowoon Yi; Younhea Jung; Chan Kee Park
Tags: eye, glaucoma, glaucoma surgery, myopia, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4170-4179. doi:https://doi.org/10.1167/iovs.16-19564
Intereye Difference in the Microstructure of Parapapillary Atrophy in Unilateral Primary Open-Angle Glaucoma Open Access
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Yung Ju Yoo; Eun Ji Lee; Tae-Woo Kim
Tags: atrophy, eye, glaucoma, open-angle glaucoma, optic disk
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4187-4193. doi:https://doi.org/10.1167/iovs.16-19059
Glaucoma Diagnostic Ability of the New Circumpapillary Retinal Nerve Fiber Layer Thickness Analysis Based on Bruch's Membrane Opening Open Access
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Eun Ji Lee; Kyoung Min Lee; Hyunjoong Kim; Tae-Woo Kim
Tags: glaucoma, eye, bruch's basal membrane
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4194-4204. doi:https://doi.org/10.1167/iovs.16-19578
Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma Open Access
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Jean Kim; Max Kudisch; Sri Mudumba; Hiroyuki Asada; Eri Aya-Shibuya; Robert B. Bhisitkul; Tejal A. Desai
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4341-4346. doi:https://doi.org/10.1167/iovs.16-19585
The Combination of PlGF Inhibition and MMC as a Novel Anti-Scarring Strategy for Glaucoma Filtration Surgery Open Access
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Tine Van Bergen; Bart Jonckx; Lieve Moons; Jean H. M. Feyen; Ingeborg Stalmans
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4347-4355. doi:https://doi.org/10.1167/iovs.16-19725
Peripapillary Nerve Fiber Elevation in Young Healthy Eyes Open Access
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Takehiro Yamashita; Taiji Sakamoto; Naoya Yoshihara; Hiroto Terasaki; Minoru Tanaka; Yuya Kii; Kumiko Nakao
Tags: eye, nerve fibers, optic disk, ophthalmic conus, ophthalmoscopy
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4368-4372. doi:https://doi.org/10.1167/iovs.16-19484
Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury Open Access
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Brad Fortune; Juan Reynaud; Christy Hardin; Lin Wang; Ian A. Sigal; Claude F. Burgoyne
Tags: axon, body tissue, compression, eye, glaucoma
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4403-4411. doi:https://doi.org/10.1167/iovs.16-20000
A Population-Based Assessment of the Agreement Between Grading of Goniophotographic Images and Gonioscopy in the Chinese-American Eye Study (CHES) Open Access
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Yohko Murakami; Dandan Wang; Bruce Burkemper; Shan C. Lin; Rohit Varma; for the Chinese-American Eye Study Group
Tags: chinese people, eye, gonioscopy, diagnostic imaging
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4512-4516. doi:https://doi.org/10.1167/iovs.15-18434

Immunology and Microbiology

Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium Open Access
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Jared E. Knickelbein; Baoying Liu; Anush Arakelyan; Sonia Zicari; Susan Hannes; Ping Chen; Zhiyu Li; Jean-Charles Grivel; Benjamin Chaigne-Delalande; H. Nida Sen; Leonid Margolis; Robert B. Nussenblatt
Tags: cytokine, extracellular vesicles, immune response, monocytes, retinal pigment epithelium
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4101-4107. doi:https://doi.org/10.1167/iovs.15-18353
Immunological Characterization of Intraocular Lymphoid Follicles in a Spontaneous Recurrent Uveitis Model Open Access
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Kristina J. H. Kleinwort; Barbara Amann; Stefanie M. Hauck; Regina Feederle; Walter Sekundo; Cornelia A. Deeg
Tags: eye, lymphoid nodule, peyer's patch, recurrence, uveitis
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4504-4511. doi:https://doi.org/10.1167/iovs.16-19787

Lens

Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment Open Access
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Rosana Mesa; Manoj Tyagi; George Harocopos; David Vollman; Steven Bassnett
Tags: epithelium, lens (device), lens, crystalline, dna, polymerase chain reaction
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4063-4075. doi:https://doi.org/10.1167/iovs.16-19726
Tropomodulin 1 Regulation of Actin Is Required for the Formation of Large Paddle Protrusions Between Mature Lens Fiber Cells Open Access
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Catherine Cheng; Roberta B. Nowak; Sondip K. Biswas; Woo-Kuen Lo; Paul G. FitzGerald; Velia M. Fowler
Tags: actins, lens (device), lens, crystalline, spectrin
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4084-4099. doi:https://doi.org/10.1167/iovs.16-19949
Spatially Directed Proteomics of the Human Lens Outer Cortex Reveals an Intermediate Filament Switch Associated With the Remodeling Zone Open Access
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Jamie L. Wenke; W. Hayes McDonald; Kevin L. Schey
Tags: intermediate filaments, lens, crystalline, proteins, proteomics, lens (device)
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4108-4114. doi:https://doi.org/10.1167/iovs.16-19791

Low Vision

Depression in Visual Impairment Trial (DEPVIT): A Randomized Clinical Trial of Depression Treatments in People With Low Vision Open Access
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Claire L. Nollett; Nathan Bray; Catey Bunce; Robin J. Casten; Rhiannon T. Edwards; Mark T. Hegel; Sarah Janikoun; Sandra E. Jumbe; Barbara Ryan; Julia Shearn; Daniel J. Smith; Miles Stanford; Wen Xing; Tom H. Margrain
Tags: depressive disorders, visual impairment, clinical trials
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4247-4254. doi:https://doi.org/10.1167/iovs.16-19345

Multidisciplinary Ophthalmic Imaging

In Vivo Imaging of the Human Retinal Pigment Epithelial Mosaic Using Adaptive Optics Enhanced Indocyanine Green Ophthalmoscopy Open Access
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Johnny Tam; Jianfei Liu; Alfredo Dubra; Robert Fariss
Tags: diagnostic imaging, indocyanine green, mosaicism, ophthalmoscopy, optics
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4376-4384. doi:https://doi.org/10.1167/iovs.16-19503
Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography Open Access
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Simon S. Gao; Yali Jia; Liang Liu; Miao Zhang; Hana L. Takusagawa; John C. Morrison; David Huang
Tags: angiogram, optical coherence tomography, face
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4485-4492. doi:https://doi.org/10.1167/iovs.16-20080

Physiology and Pharmacology

Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles Open Access
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Travis W. Hein; Wenjuan Xu; Xin Xu; Lih Kuo
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4333-4340. doi:https://doi.org/10.1167/iovs.16-19990
Suppression of Acid Sphingomyelinase Protects the Retina from Ischemic Injury Open Access
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Jie Fan; Bill X. Wu; Craig E. Crosson
Tags: ischemia, retina, sphingomyelinase, wounds and injuries, sphingolipids
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4476-4484. doi:https://doi.org/10.1167/iovs.16-19717

Retina

Connexin43 Mimetic Peptide Improves Retinal Function and Reduces Inflammation in a Light-Damaged Albino Rat Model Open Access
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Cindy X. Guo; Mohd N. Mat Nor; Helen V. Danesh-Meyer; Kirstan A. Vessey; Erica L. Fletcher; Simon J. O'Carroll; Monica L. Acosta; Colin R. Green
Tags: albinism, connexin 43, inflammation, peptides, electroretinography
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3961-3973. doi:https://doi.org/10.1167/iovs.15-16643
A Swine Model of Selective Geographic Atrophy of Outer Retinal Layers Mimicking Atrophic AMD: A Phase I Escalating Dose of Subretinal Sodium Iodate Open Access
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Jordi Monés; Marta Leiva; Teresa Peña; Gema Martínez; Marc Biarnés; Miriam Garcia; Anna Serrano; Eduardo Fernandez
Tags: atrophic condition of skin, atrophy, iodates, sodium, suidae
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3974-3983. doi:https://doi.org/10.1167/iovs.16-19355
Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia Open Access
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Christopher S. Langlo; Emily J. Patterson; Brian P. Higgins; Phyllis Summerfelt; Moataz M. Razeen; Laura R. Erker; Maria Parker; Frederick T. Collison; Gerald A. Fishman; Christine N. Kay; Jing Zhang; Richard G. Weleber; Paul Yang; David J. Wilson; Mark E. Pennesi; Byron L. Lam; John Chiang; Jeffrey D. Chulay; Alfredo Dubra; William W. Hauswirth; Joseph Carroll; for the ACHM-001 Study Group
Tags: achromatopsia, retinal cone
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 3984-3995. doi:https://doi.org/10.1167/iovs.16-19313
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy Open Access
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Felicitas Bucher; Johanna M. Walz; Anima Bühler; Edith Aguilar; Clemens Lange; Sophia Diaz-Aguilar; Gottfried Martin; Günther Schlunck; Hansjürgen Agostini; Martin Friedlander; Andreas Stahl
Tags: ciliary neurotrophic factor, retinal diseases, oxygen, up-regulation (physiology), mice
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4017-4026. doi:https://doi.org/10.1167/iovs.15-18508
The Intraocular Cytokine Profile and Therapeutic Response in Persistent Neovascular Age-Related Macular Degeneration Open Access
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Sandra Rezar-Dreindl; Stefan Sacu; Katharina Eibenberger; Andreas Pollreisz; Wolf Bühl; Michael Georgopoulos; Christoph Krall; Günther Weigert; Ursula Schmidt-Erfurth
Tags: cytokine, exudative age-related macular degeneration, persistence
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4144-4150. doi:https://doi.org/10.1167/iovs.16-19772
Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes Open Access
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Deoye Tonade; Haitao Liu; Timothy S. Kern
Tags: diabetes mellitus, endothelial cells, photoreceptors, inflammation, inflammation mediators
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4264-4271. doi:https://doi.org/10.1167/iovs.16-19859
Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes Open Access
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Haitao Liu; Jie Tang; Yunpeng Du; Aicha Saadane; Deoye Tonade; Ivy Samuels; Alex Veenstra; Krzysztof Palczewski; Timothy S. Kern
Tags: diabetes mellitus, diabetes mellitus, type 2, mice, opsin, photoreceptors
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4272-4281. doi:https://doi.org/10.1167/iovs.16-19415
Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa Open Access
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Kohta Fujiwara; Yasuhiro Ikeda; Yusuke Murakami; Shunji Nakatake; Takashi Tachibana; Noriko Yoshida; Shintaro Nakao; Toshio Hisatomi; Shigeo Yoshida; Takeshi Yoshitomi; Koh-Hei Sonoda; Tatsuro Ishibashi
Tags: epiretinal membrane, retinitis pigmentosa
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4282-4286. doi:https://doi.org/10.1167/iovs.16-19686
Sildenafil Improves Functional and Structural Outcome of Retinal Injury Following Term Neonatal Hypoxia-Ischemia Open Access
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Suna Jung; Aaron Johnstone; Zehra Khoja; Emmanouil Rampakakis; Pierre Lachapelle; Pia Wintermark
Tags: hypoxia, ischemia, newborn, retina, retinal injuries
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4306-4314. doi:https://doi.org/10.1167/iovs.16-19385
Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms Open Access
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Lebriz Altay; Paula Scholz; Tina Schick; Moritz Felsch; Carel B. Hoyng; Anneke I. den Hollander; Thomas Langmann; Sascha Fauser
Tags: age-related macular degeneration, heart failure, polymorphism, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4315-4320. doi:https://doi.org/10.1167/iovs.15-18855
Microcirculatory Responses to Hyperoxia in Macular and Peripapillary Regions Open Access
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Huan Xu; Guohua Deng; Chunhui Jiang; Xiangmei Kong; Jian Yu; Xinghuai Sun
Tags: hyperoxia, retina
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4464-4468. doi:https://doi.org/10.1167/iovs.16-19603
Spatial Distribution of Macular Pigment in an Elderly French Population: The Montrachet Study Open Access
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Seydou Alassane; Christine Binquet; Louis Arnould; Olivier Fleck; Niyazi Acar; Cécile Delcourt; Lionel Bretillon; Alain M. Bron; Catherine Creuzot-Garcher
Tags: french, macular pigment, older adult
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4469-4475. doi:https://doi.org/10.1167/iovs.16-19958
A Qualitative and Quantitative Assessment of Fundus Autofluorescence Patterns in Patients With Choroideremia Open Access
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Jasleen K. Jolly; Thomas L. Edwards; Jonathan Moules; Markus Groppe; Susan M. Downes; Robert E. MacLaren
Tags: autofluorescence, choroideremia, eye, fundus autofluorescence imaging
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4498-4503. doi:https://doi.org/10.1167/iovs.15-18362

Retinal Cell Biology

Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy Open Access
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Manish Mishra; John Lillvis; Berhane Seyoum; Renu A. Kowluru
Tags: biological markers, diabetic retinopathy, dna, mitochondrial, diabetes mellitus
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4035-4044. doi:https://doi.org/10.1167/iovs.16-19073
Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration Open Access
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Elad Moisseiev; Zeljka Smit-McBride; Sharon Oltjen; Pengfei Zhang; Robert J. Zawadzki; Monica Motta; Christopher J. Murphy; Whitney Cary; Geralyn Annett; Jan A. Nolta; Susanna S. Park
Tags: eye, intravitreal injections, mice, retina, retinal degeneration
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4125-4135. doi:https://doi.org/10.1167/iovs.16-19252
Curcumin Protects Trabecular Meshwork Cells From Oxidative Stress Open Access
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Chaobin Lin; Xiaomin Wu
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4327-4332. doi:https://doi.org/10.1167/iovs.16-19883
Defective Autophagy in Diabetic Retinopathy Open Access
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Jacqueline M. Lopes de Faria; Diego A. Duarte; Chiara Montemurro; Alexandros Papadimitriou; Sílvio Roberto Consonni; José B. Lopes de Faria
Tags: apoptosis, autophagy, cardiac support procedures, diabetic retinopathy, mast-cell sarcoma
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4356-4366. doi:https://doi.org/10.1167/iovs.16-19197
Secretion Profile of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium During Wound Healing Open Access
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Whitney A. Greene; Teresa A. Burke; Elaine D. Por; Ramesh R. Kaini; Heuy-Ching Wang
Tags: bodily secretions, wound healing, retinal pigment epithelium, wounds and injuries
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4428-4441. doi:https://doi.org/10.1167/iovs.16-19192
Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish Open Access
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Ping Song; Lynn Dudinsky; Joseph Fogerty; Robert Gaivin; Brian D. Perkins
Tags: cilia, photoreceptors, zebrafish, tissue degeneration
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4517-4526. doi:https://doi.org/10.1167/iovs.16-19898

Visual Neuroscience

Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine Open Access
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Michael A. Bergen; Han na Park; Ranjay Chakraborty; Erica G. Landis; Curran Sidhu; Li He; P. Michael Iuvone; Machelle T. Pardue
Tags: dopamine, mice, myopia
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4412-4419. doi:https://doi.org/10.1167/iovs.15-17784

Visual Psychophysics and Physiological Optics

Microperimetry as an Outcome Measure in Choroideremia Trials: Reproducibility and Beyond Open Access
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Ioannis S. Dimopoulos; Calvin Tseng; Ian M. MacDonald
Tags: choroideremia, outcome measures, retina, tissue degeneration
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4151-4161. doi:https://doi.org/10.1167/iovs.16-19338

Letters to the Editor

Concerning Manuscript “Deficient Binocular Combination of Second-Order Stimuli in Amblyopia” Open Access
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Qian Li; Longqian Liu
Tags: amblyopia
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4214. doi:https://doi.org/10.1167/iovs.16-20063
Author Response: Concerning Manuscript “Deficient Binocular Combination of Second-Order Stimuli in Amblyopia” Open Access
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Jiawei Zhou; Rong Liu; Lixia Feng; Yifeng Zhou; Robert F. Hess
Tags: amblyopia
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4215. doi:https://doi.org/10.1167/iovs.16-20206
Peripapillary Suprachoroidal Cavitation, Parapapillary Gamma Zone and Optic Disc Rotation Due to the Biomechanics of the Optic Nerve Dura Mater Open Access
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Jost B. Jonas; Yi Dai; Songhomitra Panda-Jonas
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4373. doi:https://doi.org/10.1167/iovs.16-19885
Author Response: Peripapillary Suprachoroidal Cavitation, Parapapillary Gamma Zone and Optic Disc Rotation Due to the Biomechanics of the Optic Nerve Dura Mater Open Access
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Xiaofei Wang; Helmut Rumpel; Winston Eng Hoe Lim; Mani Baskaran; Shamira A. Perera; Monisha E. Nongpiur; Tin Aung; Dan Milea; Michaël J. A. Girard
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4374-4375. doi:https://doi.org/10.1167/iovs.16-20118
Neutral-Density Filters Are Not a Patch on Occlusion Open Access
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Jiawei Zhou; Robert F. Hess
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4450-4451. doi:https://doi.org/10.1167/iovs.16-20316

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4016. doi:https://doi.org/10.1167/iovs.15-18539a
Erratum Open Access
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Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4213. doi:https://doi.org/10.1167/iovs.16-19405a
Erratum Open Access
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Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4367. doi:https://doi.org/10.1167/iovs.14-14353a
Erratum Open Access
PDF
Investigative Ophthalmology & Visual Science August 2016, Vol.57, 4527. doi:https://doi.org/10.1167/iovs.14-14042a
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