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Research Highlight

Myopia and Outdoor Exposures Open Access
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Frank Schaeffel; Marita Feldkaemper
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4790. doi:https://doi.org/10.1167/iovs.16-20540
Mutations in Linkage Disequilibrium With Putative Disease-Causing Mutations Open Access
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Stephen P. Daiger
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4814. doi:https://doi.org/10.1167/iovs.16-20334
The Optic Nerve in Moving Pictures Open Access
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Joseph L. Demer
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4988. doi:https://doi.org/10.1167/iovs.16-20570

Anatomy and Pathology/Oncology

Development of Experimental Myopia in Chicks in a Natural Environment Open Access
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Richard A. Stone; Yuval Cohen; Alice M. McGlinn; Sherrill Davison; Susan Casavant; James Shaffer; Tejvir S. Khurana; Machelle T. Pardue; P. Michael Iuvone
Tags: myopia, dopamine, eye, cohort studies, 3,4-dihydroxyphenylacetic acid
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4779-4789. doi:https://doi.org/10.1167/iovs.16-19310
Characterization of Antigen-Presenting Macrophages and Dendritic Cells in the Healthy Human Sclera Open Access
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Simona L. Schlereth; Stefan Kremers; Falk Schrödl; Claus Cursiefen; Ludwig M. Heindl
Tags: dendritic cells, macrophages, sclera, antigens, antigen-presenting cells
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4878-4885. doi:https://doi.org/10.1167/iovs.15-18552
Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia Open Access
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Angelica R. Harper; Xiang Wang; Gennadiy Moiseyev; Jian-Xing Ma; Jody A. Summers
Tags: body tissue, choroid, myopia, oxidoreductase, proteins
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4886-4897. doi:https://doi.org/10.1167/iovs.16-19395
Combination of Carboplatin and Bevacizumab Is an Efficient Therapeutic Approach in Retinoblastoma Patient-Derived Xenografts Open Access
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Franck Assayag; André Nicolas; Sophie Vacher; Catherine Dehainault; Ivan Bieche; Didier Meseure; Isabelle Aerts; Nathalie Cassoux; Claude Houdayer; François Doz; Didier Decaudin
Tags: bevacizumab, carboplatin, retinoblastoma, transplantation, heterologous, neoplasms
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4916-4926. doi:https://doi.org/10.1167/iovs.15-18725

Biochemistry and Molecular Biology

A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells Open Access
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Preeti Subramanian; Emily F. Mendez; S. Patricia Becerra
Tags: arachidonate 5-lipoxygenase, cell death, oxidative stress, peptides, retinal pigment cell
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4581-4588. doi:https://doi.org/10.1167/iovs.15-19039
Relationship Between the Altered Expression and Epigenetics of GSTM3 and Age-Related Cataract Open Access
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Bo Li; Jing Zhou; Guowei Zhang; Yong Wang; Lihua Kang; Jian Wu; Jia Chen; Huaijin Guan
Tags: cataract, senile, cell lines, dna, epigenetics, histones
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4721-4732. doi:https://doi.org/10.1167/iovs.16-19242
The Antiproliferative Effect of Bevacizumab on Human Tenon Fibroblasts Is Not Mediated by Vascular Endothelial Growth Factor Inhibition Open Access
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Charlotte V. Fischer; Viktoria Mans; Maren Horn; Sabine Naxer; Alexa Klettner; Christian van Oterendorp
Tags: bevacizumab, fibroblasts, vascular endothelial growth factor a, antibodies, cell culture techniques
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4970-4977. doi:https://doi.org/10.1167/iovs.16-19938
Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration Open Access
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Margaret Po-shan Luke; Terry L. LeVatte; Urs Rutishauser; François Tremblay; David B. Clarke
Tags: neural cell adhesion molecules, prostate-specific antigen, retina, retinal degeneration, mice
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5066-5075. doi:https://doi.org/10.1167/iovs.16-19499

Clinical and Epidemiologic Research

Differential Impact of Unilateral and Bilateral Classifications of Diabetic Retinopathy and Diabetic Macular Edema on Vision-Related Quality of Life Open Access
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Ryan Eyn Kidd Man; Eva K. Fenwick; Charumathi Sabanayagam; Ling-Jun Li; Ching Siong Tey; Hasita Jian Tai Soon; Gemmy Chui-Ming Cheung; Gavin Siew Wei Tan; Tien Yin Wong; Ecosse L. Lamoureux
Tags: diabetic macular edema, diabetic retinopathy, quality of life, vision, eye
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4655-4660. doi:https://doi.org/10.1167/iovs.16-20165
Individual Differences in Foveal Shape: Feasibility of Individual Maps Between Structure and Function Within the Macular Region Open Access
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Juan A. Sepulveda; Andrew Turpin; Allison M. McKendrick
Tags: maps
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4772-4778. doi:https://doi.org/10.1167/iovs.16-19288
The Relationship of Novel Plasma Proteins in the Early Neonatal Period With Retinopathy of Prematurity Open Access
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Anne M. Lynch; Brandie D. Wagner; Naresh Mandava; Alan G. Palestine; Peter M. Mourani; Emily A. McCourt; Scott C. N. Oliver; Steven H. Abman
Tags: infant, newborn, plasma proteins, proteins, retinopathy of prematurity
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5076-5082. doi:https://doi.org/10.1167/iovs.16-19653

Cornea

Allogeneic Sensitization and Tolerance Induction After Corneal Endothelial Cell Transplantation in Mice Open Access
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Jun Yamada; Morio Ueno; Munetoyo Toda; Katsuhiko Shinomiya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: cornea, endothelial cells, injections, mice, transplantation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4572-4580. doi:https://doi.org/10.1167/iovs.15-19020
The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components Open Access
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Munetoyo Toda; Morio Ueno; Jun Yamada; Asako Hiraga; Hiroshi Tanaka; Ursula Schlötzer-Schrehardt; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: collagen, cornea, descemet's membrane, endothelial cells, laminin
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4599-4605. doi:https://doi.org/10.1167/iovs.16-20087
In Vivo Confocal Microscopy in Dry Eye Disease Associated With Chronic Graft-Versus-Host Disease Open Access
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Ahmad Kheirkhah; Yureeda Qazi; Michael A. Arnoldner; Kunal Suri; Reza Dana
Tags: dry eye syndromes, graft-versus-host disease, graft-versus-host disease, chronic, microscopy, confocal, cornea
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4686-4691. doi:https://doi.org/10.1167/iovs.16-20013
Cell Homogeneity Indispensable for Regenerative Medicine by Cultured Human Corneal Endothelial Cells Open Access
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Junji Hamuro; Munetoyo Toda; Kazuko Asada; Asako Hiraga; Ursula Schlötzer-Schrehardt; Monty Montoya; Chie Sotozono; Morio Ueno; Shigeru Kinoshita
Tags: cd44 antigens, cornea, donors, endothelial cells, homing-associated cell adhesion molecule
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4749-4761. doi:https://doi.org/10.1167/iovs.16-19770
Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease Open Access
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David Charles Jackson; Weiguang Zeng; Chinn Yi Wong; Edin Jessica Mifsud; Nicholas Andrew Williamson; Ching-Seng Ang; Algis Jonas Vingrys; Laura Elizabeth Downie
Tags: biological markers, cytokine, dry eye syndromes, interferon type ii, osmolar concentration
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 4824-4830. doi:https://doi.org/10.1167/iovs.16-19757
Assessment of Transepidermal Water Loss From the Ocular Area in Dry Eye Disease Open Access
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Hyun Sun Jeon; Sang Woong Youn; Hee Eun Jeon; Joo Hyun Kim; Joon Young Hyon
Tags: dry eye syndromes, transepidermal water loss rate, evaporation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4831-4836. doi:https://doi.org/10.1167/iovs.16-20109
Corneal Hydration Control in Fuchs' Endothelial Corneal Dystrophy Open Access
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Katrin Wacker; Jay W. McLaren; Katrina M. Kane; Keith H. Baratz; Sanjay V. Patel
Tags: cornea, endothelium, fluid management, hereditary corneal dystrophy, edema
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5060-5065. doi:https://doi.org/10.1167/iovs.16-20205

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Fine Motor Skills of Children With Amblyopia Improve Following Binocular Treatment Open Access
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Ann L. Webber; Joanne M. Wood; Benjamin Thompson
Tags: amblyopia, child, fine motor skills
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4713-4720. doi:https://doi.org/10.1167/iovs.16-19797
Gaze Evoked Deformations of the Peripapillary Retina in Papilledema and Ischemic Optic Neuropathy Open Access
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Patrick A. Sibony
Tags: adduction, gaze, papilledema, shape, optic neuropathy, ischemic
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4979-4987. doi:https://doi.org/10.1167/iovs.16-19931

Genetics

Reevaluation of the Retinal Dystrophy Due to Recessive Alleles of RGR With the Discovery of a Cis-Acting Mutation in CDHR1 Open Access
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Gavin Arno; Sarah Hull; Keren Carss; Arundhati Dev-Borman; Christina Chakarova; Kinga Bujakowska; L. Ingeborgh van den Born; Anthony G. Robson; Graham E. Holder; Michel Michaelides; Frans P. M. Cremers; Eric Pierce; F. Lucy Raymond; Anthony T. Moore; Andrew R. Webster
Tags: alleles, mutation, retinal dystrophies, homozygote
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4806-4813. doi:https://doi.org/10.1167/iovs.16-19687
Novel RP1L1 Variants and Genotype–Photoreceptor Microstructural Phenotype Associations in Cohort of Japanese Patients With Occult Macular Dystrophy Open Access
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Kaoru Fujinami; Shuhei Kameya; Sachiko Kikuchi; Shinji Ueno; Mineo Kondo; Takaaki Hayashi; Kei Shinoda; Shigeki Machida; Kazuki Kuniyoshi; Yuichi Kawamura; Masakazu Akahori; Kazutoshi Yoshitake; Satoshi Katagiri; Ayami Nakanishi; Hiroyuki Sakuramoto; Yoko Ozawa; Kazuo Tsubota; Kunihiko Yamaki; Atsushi Mizota; Hiroko Terasaki; Yozo Miyake; Takeshi Iwata; Kazushige Tsunoda
Tags: cohort studies, genes, genotype, macular dystrophy, phenotype
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4837-4846. doi:https://doi.org/10.1167/iovs.16-19670
Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses Open Access
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Anthony P. Khawaja; Jessica N. Cooke Bailey; Jae Hee Kang; R. Rand Allingham; Michael A. Hauser; Murray Brilliant; Donald L. Budenz; William G. Christen; John Fingert; Douglas Gaasterland; Terry Gaasterland; Peter Kraft; Richard K. Lee; Paul R. Lichter; Yutao Liu; Felipe Medeiros; Syoko E. Moroi; Julia E. Richards; Tony Realini; Robert Ritch; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret Pericak-Vance; Robert N. Weinreb; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs
Tags: genes, genetics, mitochondria, open-angle glaucoma
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5046-5052. doi:https://doi.org/10.1167/iovs.16-20017

Glaucoma

Aqueous Angiography–Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes Open Access
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Alex S. Huang; Sindhu Saraswathy; Anna Dastiridou; Alan Begian; Chirayu Mohindroo; James C. H. Tan; Brian A. Francis; David R. Hinton; Robert N. Weinreb
Tags: angiogram, bypass, eye, surgical procedures, operative, fluorescein
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4558-4565. doi:https://doi.org/10.1167/iovs.16-19644
Computational Study of Aqueous Humor Dynamics Assessing the Vault and the Pupil Diameter in Two Posterior-Chamber Phakic Lenses Open Access
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José Ignacio Fernández-Vigo; Ana Macarro-Merino; Joaquín Fernández-Francos; Lucía De-Pablo-Gómez-de-Liaño; José María Martínez-de-la-Casa; Julián García-Feijóo; José Ángel Fernández-Vigo
Tags: aqueous humor, diameter, hypertension, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4625-4631. doi:https://doi.org/10.1167/iovs.16-19900
Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma Open Access
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Masoud Aghsaei Fard; Marjan Afzali; Parisa Abdi; Rebecca Chen; Mehdi Yaseri; Ebrahim Azaripour; Sasan Moghimi
Tags: glaucoma, nonarteritic anterior ischemic optic neuropathy, open-angle glaucoma, optic disk, language morphology
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4632-4640. doi:https://doi.org/10.1167/iovs.16-19442
Loss of Melanopsin-Expressing Retinal Ganglion Cells in Severely Staged Glaucoma Patients Open Access
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Elisabeth Anne Obara; Jens Hannibal; Steffen Heegaard; Jan Fahrenkrug
Tags: glaucoma, melanopsin, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4661-4667. doi:https://doi.org/10.1167/iovs.16-19997
Influence of Exercise on Intraocular Pressure, Schlemm's Canal, and the Trabecular Meshwork Open Access
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Xiaoqin Yan; Mu Li; Yinwei Song; Jingmin Guo; Yin Zhao; Wei Chen; Hong Zhang
Tags: exercise, intraocular pressure, schlemm's canal, trabecular meshwork
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4733-4739. doi:https://doi.org/10.1167/iovs.16-19475
Tetramethylpyrazine Attenuates Transdifferentiation of TGF-β2–Treated Human Tenon's Fibroblasts Open Access
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Xiaoxiao Cai; Yangfan Yang; Pei Chen; Yiming Ye; Xiao'an Liu; Kaili Wu; Minbin Yu
Tags: attenuation, cell transdifferentiation, fibroblasts, fibrosis, fluorescent antibody technique
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4740-4748. doi:https://doi.org/10.1167/iovs.16-19529
Glaucoma Diagnostic Ability of Layer-by-Layer Segmented Ganglion Cell Complex by Spectral-Domain Optical Coherence Tomography Open Access
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Hae Jin Kim; Sang-Yoon Lee; Ki Ho Park; Dong Myung Kim; Jin Wook Jeoung
Tags: ganglia, glaucoma
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4799-4805. doi:https://doi.org/10.1167/iovs.16-19214
Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range Open Access
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Arezoo Miraftabi; Navid Amini; Esteban Morales; Sharon Henry; Fei Yu; Abdolmonem Afifi; Anne L. Coleman; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: glaucoma, outcome measures, visual fields
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4815-4823. doi:https://doi.org/10.1167/iovs.16-19648
Shape Changes of the Anterior Lamina Cribrosa in Normal, Ocular Hypertensive, and Glaucomatous Eyes Following Acute Intraocular Pressure Elevation Open Access
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Tin A. Tun; Sri Gowtham Thakku; Owen Png; Mani Baskaran; Hla M. Htoon; Sourabh Sharma; Monisha E. Nongpiur; Ching-Yu Cheng; Tin Aung; Nicholas G. Strouthidis; Michaël J. A. Girard
Tags: glaucoma, intraocular pressure, eye, cribriform plate, ocular hypertension
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4869-4877. doi:https://doi.org/10.1167/iovs.16-19753
Comparison of Several Parameters in Two Optical Coherence Tomography Systems for Detecting Glaucomatous Defects in High Myopia Open Access
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Yuqiu Zhang; Wen Wen; Xinghuai Sun
Tags: glaucoma, myopia, optical coherence tomography
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4910-4915. doi:https://doi.org/10.1167/iovs.16-19104
Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma Open Access
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Seung Hyen Lee; Da-Ae Yu; Tae-Woo Kim; Eun Ji Lee; Michaël J. A. Girard; Jean Martial Mari
Tags: cribriform plate, glaucoma, preoperative care, trabeculectomy, intraocular pressure
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5006-5014. doi:https://doi.org/10.1167/iovs.15-18982
Heterozygous Pitx2 Null Mice Accurately Recapitulate the Ocular Features of Axenfeld-Rieger Syndrome and Congenital Glaucoma Open Access
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Lisheng Chen; Philip J. Gage
Tags: mice, syndrome, glaucoma, congenital, heterozygote, eye
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5023-5030. doi:https://doi.org/10.1167/iovs.16-19700

Immunology and Microbiology

The Cytokine Interleukin-6 and the Chemokines CCL20 and CXCL13 Are Novel Biomarkers of Specific Endogenous Uveitic Entities Open Access
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Ahmed M. Abu El-Asrar; Nele Berghmans; Saleh A. Al-Obeidan; Ahmed Mousa; Ghislain Opdenakker; Jo Van Damme; Sofie Struyf
Tags: biological markers, chemokine cxcl13, chemokines, cytokine, hypertension
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4606-4613. doi:https://doi.org/10.1167/iovs.16-19758

Lens

The Immunoproteasome in Human Lens Epithelial Cells During Oxidative Stress Open Access
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Anne Petersen; Madeleine Zetterberg
Tags: epithelial cells, lens, crystalline, multicatalytic endopeptidase complex, oxidative stress, proteins
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5038-5045. doi:https://doi.org/10.1167/iovs.16-19536

Low Vision

Standing Balance Stability and the Effects of Light Touch in Adults With Profound Loss of Vision—An Exploratory Study Open Access
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Aachal Kotecha; Andrew Royston Webster; Genevieve Wright; Michel Michaelides; Gary Stuart Rubin
Tags: balance, device, blindness, equilibrium, touch sensation, therapeutic touch
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5053-5059. doi:https://doi.org/10.1167/iovs.16-19606

Multidisciplinary Ophthalmic Imaging

Peripapillary Pachychoroid in Nonarteritic Anterior Ischemic Optic Neuropathy Open Access
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Lina Nagia; Carrie Huisingh; John Johnstone; Lanning B. Kline; Mark Clark; Michael J. A. Girard; Jean Martial Mari; Christopher A. Girkin
Tags: nonarteritic anterior ischemic optic neuropathy, eye
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4679-4685. doi:https://doi.org/10.1167/iovs.16-19315

Physiology and Pharmacology

Retinal Vessel Diameter Responses to Central Electrical Stimulation in the Rat: Effect of Nitric Oxide Synthase Inhibition Open Access
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Clemens A. Strohmaier; Karolina Motloch; Christian Runge; Andrea Trost; Barbara Bogner; Alexandra Kaser-Eichberger; Falk Schrödl; Markus Lenzhofer; Herbert A. Reitsamer
Tags: diameter, electric stimulation, nitric oxide synthase, retinal vessels, ng-nitroarginine methyl ester
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4553-4557. doi:https://doi.org/10.1167/iovs.16-19452

Retina

The Characteristics of Retinal Emboli and its Association With Vascular Reperfusion in Retinal Artery Occlusion Open Access
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Kwan Hyuk Cho; Seong Joon Ahn; Joon Hee Cho; Cheolkyu Jung; Moon-Ku Han; Sang Jun Park; Kyu Hyung Park; Se Joon Woo
Tags: embolism, physiologic reperfusion, reperfusion therapy, retinal artery occlusion, retinal embolus
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4589-4598. doi:https://doi.org/10.1167/iovs.16-19887
Phenotype and Progression of Retinal Degeneration Associated With Nullizigosity of ABCA4 Open Access
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Ana Fakin; Anthony G. Robson; Kaoru Fujinami; Anthony T. Moore; Michel Michaelides; John (Pei-Wen) Chiang; Graham E. Holder; Andrew R. Webster
Tags: electroretinography, mutation, phenotype, retinal degeneration, rna splicing
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4668-4678. doi:https://doi.org/10.1167/iovs.16-19829
Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion Open Access
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Wahiba Hadj-Saïd; Nicolas Froger; Ivana Ivkovic; Manuel Jiménez-López; Élisabeth Dubus; Julie Dégardin-Chicaud; Manuel Simonutti; César Quénol; Nathalie Neveux; María Paz Villegas-Pérez; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Jose-Alain Sahel; Serge Picaud; Diego García-Ayuso
Tags: retina, retinal cone, taurine, retinal degeneration, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4692-4703. doi:https://doi.org/10.1167/iovs.16-19535
Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina Open Access
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Rosemary E. McDowell; Mary K. McGahon; Josy Augustine; Mei Chen; J. Graham McGeown; Tim M. Curtis
Tags: aldehyde dehydrogenases, aldehydes, diabetes mellitus, diabetes mellitus, type 2, retina
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4762-4771. doi:https://doi.org/10.1167/iovs.16-19424
Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor Open Access
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Shinichi Otani; Taiji Nagaoka; Tsuneaki Omae; Ichiro Tanano; Takayuki Kamiya; Shinji Ono; Travis W. Hein; Lih Kuo; Akitoshi Yoshida
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4791-4798. doi:https://doi.org/10.1167/iovs.15-19038
Complexity of the Class B Phenotype in Autosomal Dominant Retinitis Pigmentosa Due to Rhodopsin Mutations Open Access
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Samuel G. Jacobson; David B. McGuigan, III; Alexander Sumaroka; Alejandro J. Roman; Michaela L. Gruzensky; Rebecca Sheplock; Judy Palma; Sharon B. Schwartz; Tomas S. Aleman; Artur V. Cideciyan
Tags: family, mutation, pathophysiology, phenotype, retina
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4847-4858. doi:https://doi.org/10.1167/iovs.16-19890
Modeling the Chronic Loss of Optic Nerve Axons and the Effects on the Retinal Nerve Fiber Layer Structure in Primary Disorder of Myelin Open Access
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Leandro B. C. Teixeira; James N. Ver Hoeve; Joshua A. Mayer; Richard R. Dubielzig; Chelsey M. Smith; Abigail B. Radcliff; Ian D. Duncan
Tags: atrophy, axon, myelin, optic nerve, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4859-4868. doi:https://doi.org/10.1167/iovs.16-19871
Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy Open Access
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Maria Vähätupa; Stuart Prince; Suvi Vataja; Teija Mertimo; Marko Kataja; Kati Kinnunen; Varpu Marjomäki; Hannu Uusitalo; Masanobu Komatsu; Tero A.H. Järvinen; Hannele Uusitalo–Järvinen
Tags: angiogenesis, cadherins, ischemia, mice, retina
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4898-4909. doi:https://doi.org/10.1167/iovs.16-19212
Separate and Combined Effects of Hypoxia and Horizontal Bed Rest on Retinal Blood Vessel Diameters Open Access
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Tijs Louwies; Polona Jaki Mekjavic; Bianca Cox; Ola Eiken; Igor B. Mekjavic; Stylianos Kounalakis; Patrick De Boever
Tags: bed rest, hypoxia, retinal vessels
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4927-4932. doi:https://doi.org/10.1167/iovs.16-19968
Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year Open Access
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Wei Yan Ng; Daniel Shu Wei Ting; Rupesh Agrawal; Neha Khandelwal; Hla Myint Htoon; Shu Yen Lee; Tien Yin Wong; Gemmy Chui Ming Cheung
Tags: choroidal neovascularization, cortical blindness, endothelial growth factors, eye
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4933-4939. doi:https://doi.org/10.1167/iovs.16-20191
Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Eyes With Diabetic Retinopathy Open Access
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Sarwar Zahid; Rosa Dolz-Marco; K. Bailey Freund; Chandrakumar Balaratnasingam; Kunal Dansingani; Fatimah Gilani; Nitish Mehta; Emma Young; Meredith R. Klifto; Bora Chae; Lawrence A. Yannuzzi; Joshua A. Young
Tags: angiogram, diabetes mellitus, diabetic retinopathy, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4940-4947. doi:https://doi.org/10.1167/iovs.16-19656
Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats Open Access
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Youngseok Song; Taiji Nagaoka; Takafumi Yoshioka; Shinji Ono; Takanari Wada; Seigo Nakabayashi; Tomofumi Tani; Akitoshi Yoshida
Tags: endothelin-1, hyperoxia, cats, adaptive testing, vascular flow
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4962-4969. doi:https://doi.org/10.1167/iovs.16-19599
Retinal Degeneration in Mice Deficient in the Lysosomal Membrane Protein CLN7 Open Access
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Wanda Jankowiak; Laura Brandenstein; Simon Dulz; Christian Hagel; Stephan Storch; Udo Bartsch
Tags: membrane proteins, mice, phenotype, retina, retinal degeneration
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4989-4998. doi:https://doi.org/10.1167/iovs.16-20158
Fibrocytes and Fibrovascular Membrane Formation in Proliferative Diabetic Retinopathy Open Access
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Kazunori Tamaki; Ayumi Usui-Ouchi; Akira Murakami; Nobuyuki Ebihara
Tags: mass or substance concentration per volume, monocyte chemoattractant protein-1, proliferative diabetic retinopathy, tissue membrane, vitreous body
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4999-5005. doi:https://doi.org/10.1167/iovs.16-19798
Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy Open Access
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Michael B. Powner; Dawn A. Sim; Meidong Zhu; João Nobre-Cardoso; Ryan Jones; Adil Syed; Andrew A. Chang; Pearse A. Keane; Adnan Tufail; Catherine A. Egan; Marcus Fruttiger
Tags: basement membrane, ischemia, persistence, retinal diseases, retinal vasculature
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5031-5037. doi:https://doi.org/10.1167/iovs.16-20007
Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation Open Access
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Peter X. Shaw; Jiahua Fang; Alan Sang; Yan Wang; Michael S. Kapiloff; Jeffrey L. Goldberg
Tags: adenylate cyclase, mice, photoreceptors, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5083-5092. doi:https://doi.org/10.1167/iovs.16-19465

Retinal Cell Biology

Is Angiostatin Involved in Physiological Foveal Avascularity? Open Access
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Michael R. R. Böhm; Florian Hodes; Katrin Brockhaus; Stephanie Hummel; Stefan Schlatt; Harutyun Melkonyan; Solon Thanos
Tags: angiostatins, retina, fovea centralis
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4536-4552. doi:https://doi.org/10.1167/iovs.16-19286
Anatomical and Gene Expression Changes in the Retinal Pigmented Epithelium Atrophy 1 (rpea1) Mouse: A Potential Model of Serous Retinal Detachment Open Access
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Gabriel Luna; Geoffrey P. Lewis; Kenneth A. Linberg; Bo Chang; Quiri Hu; Peter J. Munson; Arvydas Maminishkis; Sheldon S. Miller; Steven K. Fisher
Tags: atrophy, epithelium, exudative retinal detachment, gene expression, mice
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4641-4654. doi:https://doi.org/10.1167/iovs.15-19044
Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells Open Access
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Gopalan Gnanaguru; Ariel R. Choi; Dhanesh Amarnani; Patricia A. D'Amore
Tags: cd36 antigens, lipoproteins, low-density lipoproteins, retinal pigment cell, inflammasomes
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4704-4712. doi:https://doi.org/10.1167/iovs.15-18663

Visual Neuroscience

Topographic Quantification of the Transcorneal Electrical Stimulation (TES)–Induced Protective Effects on N-Methyl-N-Nitrosourea–Treated Retinas Open Access
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Ye Tao; Tao Chen; Zhong-Yu Liu; Li-Qiang Wang; Wei-Wei Xu; Li-Min Qin; Guang-Hua Peng; Huang Yi-Fei
Tags: retina, transanal endoscopic surgery, mice, electric stimulation, methylnitrosourea
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4614-4624. doi:https://doi.org/10.1167/iovs.16-19305

Visual Psychophysics and Physiological Optics

The Appearance of Phosphenes Elicited Using a Suprachoroidal Retinal Prosthesis Open Access
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Nicholas C. Sinclair; Mohit N. Shivdasani; Thushara Perera; Lisa N. Gillespie; Hugh J. McDermott; Lauren N. Ayton; Peter J. Blamey; for the Bionic Vision Australia Consortium
Tags: accommodation phosphene
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4948-4961. doi:https://doi.org/10.1167/iovs.15-18991
Concurrent Investigation of Global Motion and Form Processing in Amblyopia: An Equivalent Noise Approach Open Access
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Mahesh R. Joshi; Anita J. Simmers; Seong T. Jeon
Tags: amblyopia, motion, noise
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5015-5022. doi:https://doi.org/10.1167/iovs.15-18609

Letters to the Editor

Gravity Does Not Affect Lens Position During Accommodation Open Access
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Ronald A. Schachar
Tags: force of gravity, lens (device), lens, crystalline, visual accommodation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4566-4567. doi:https://doi.org/10.1167/iovs.16-19793
Author Response: Gravity Affects Lens Position During Accommodation Open Access
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David A. Atchison; Lucas J. Lister; Marwan Suheimat; Pavan K. Verkicharla; Edward A. H. Mallen
Tags: force of gravity, lens (device), lens, crystalline, visual accommodation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4568-4569. doi:https://doi.org/10.1167/iovs.16-20068
Gravity Does Not Affect Accommodative Amplitude Open Access
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Andy T. Augousti; Barbara K. Pierscionek
Tags: force of gravity
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4570. doi:https://doi.org/10.1167/iovs.16-19827
Author Response: Gravity Affects Amplitude of Accommodation Open Access
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David A. Atchison; Lucas L. Lister; Marwan Suheimat; Pavan K. Verkicharla; Edward A. H. Mallen
Tags: force of gravity, visual accommodation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4571. doi:https://doi.org/10.1167/iovs.16-20069

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4978. doi:https://doi.org/10.1167/iovs.16-20063a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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