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Research Highlight

Stretch Sensitive Channels in Retinal Blood Flow Autoregulation Open Access
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Bang V. Bui
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5648. doi:https://doi.org/10.1167/iovs.16-20857
Amblyopic Perceptual Suppression Revealed Open Access
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Janine D. Mendola
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5655. doi:https://doi.org/10.1167/iovs.16-20851

Anatomy and Pathology/Oncology

The Role of Retinal Dopamine in C57BL/6 Mouse Refractive Development as Revealed by Intravitreal Administration of 6-Hydroxydopamine Open Access
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Xiao-Hua Wu; Kang-Wei Qian; Guo-Zhong Xu; Yun-Yun Li; Yuan-Yuan Ma; Furong Huang; Yan-Qing Wang; Xiangtian Zhou; Jia Qu; Xiong-Li Yang; Yong-Mei Zhong; Shi-Jun Weng
Tags: dopamine, mice, oxidopamine, intravitreal injections, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5393-5404. doi:https://doi.org/10.1167/iovs.16-19543
Details of the Collagen and Elastin Architecture in the Human Limbal Conjunctiva, Tenon's Capsule and Sclera Revealed by Two-Photon Excited Fluorescence Microscopy Open Access
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Choul Yong Park; Catherine M. Marando; Jason A. Liao; Jimmy K. Lee; Jiwon Kwon; Roy S. Chuck
Tags: collagen, conjunctiva, elastin, microscopy, fluorescence, photons
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5602-5610. doi:https://doi.org/10.1167/iovs.16-19706

Biochemistry and Molecular Biology

Effects of Long-term Serial Passaging on the Characteristics and Properties of Cell Lines Derived From Uveal Melanoma Primary Tumors Open Access
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Frédéric Mouriaux; Karine Zaniolo; Marjorie-Allison Bergeron; Cindy Weidmann; Arnaud De La Fouchardière; Frédéric Fournier; Arnaud Droit; Mohib W. Morcos; Solange Landreville; Sylvain L. Guérin
Tags: cell lines, neoplasms, uveal melanoma, genes
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5288-5301. doi:https://doi.org/10.1167/iovs.16-19317
Telomere Length Measurement in Different Ocular Structures: A Potential Implication in Corneal Endothelium Pathogenesis Open Access
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Marie-Catherine Drigeard Desgarnier; Corinne Zinflou; Justin D. Mallet; Sébastien P. Gendron; Sébastien J. Méthot; Patrick J. Rochette
Tags: eye, telomere, corneal endothelium, pathogenesis
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5547-5555. doi:https://doi.org/10.1167/iovs.16-19878
Molecular Mechanisms Mediating Antiangiogenic Action of the Urokinase Receptor-Derived Peptide UPARANT in Human Retinal Endothelial Cells Open Access
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Carla Motta; Gabriella Lupo; Dario Rusciano; Melania Olivieri; Liliana Lista; Mario De Rosa; Vincenzo Pavone; Carmelina Daniela Anfuso
Tags: vascular endothelial growth factor a, angiogenesis inhibitors, peptides, endothelial cells, urokinase
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5723-5735. doi:https://doi.org/10.1167/iovs.16-19909

Clinical and Epidemiologic Research

Myopia and Cognitive Performance: Results From the Gutenberg Health Study Open Access
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Alireza Mirshahi; Katharina A. Ponto; Dagmar Laubert-Reh; Benjamin Rahm; Karl J. Lackner; Harald Binder; Norbert Pfeiffer; Josef M. Unterrainer
Tags: cognitive ability, myopia, health, educational status
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5230-5236. doi:https://doi.org/10.1167/iovs.16-19507
Thyroid Dysfunction and Ten-Year Incidence of Age-Related Macular Degeneration Open Access
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Bamini Gopinath; Gerald Liew; Annette Kifley; Paul Mitchell
Tags: age-related macular degeneration, incidence, thyroid diseases, thyrotropin
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5273-5277. doi:https://doi.org/10.1167/iovs.16-19735
Conjunctival Neutrophils Predict Progressive Scarring in Ocular Mucous Membrane Pemphigoid Open Access
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Geraint P. Williams; Peter Nightingale; Sue Southworth; Alastair K. O. Denniston; Paul J. Tomlins; Stephen Turner; John Hamburger; Simon J. Bowman; S. John Curnow; Saaeha Rauz
Tags: biological markers, cicatrix, conjunctiva, cytology, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5457-5469. doi:https://doi.org/10.1167/iovs.16-19247
Vision-Related Quality of Life Outcomes in the BEVORDEX Study: A Clinical Trial Comparing Ozurdex Sustained Release Dexamethasone Intravitreal Implant and Bevacizumab Treatment for Diabet... Open Access
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Christine Aroney; Samantha Fraser-Bell; Ecosse L. Lamoureux; Mark C. Gillies; Lyndell L. Lim; Eva K. Fenwick
Tags: bevacizumab, dexamethasone, diabetic macular edema, implants, intravitreal implants
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5541-5546. doi:https://doi.org/10.1167/iovs.16-19729
Epidemiology of Reticular Pseudodrusen in Age-Related Macular Degeneration: The Rotterdam Study Open Access
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Gabriëlle H. S. Buitendijk; Ada J. Hooghart; Corina Brussee; Paulus T. V. M. de Jong; Albert Hofman; Johannes R. Vingerling; Caroline C. W. Klaver
Tags: age-related macular degeneration, diagnostic imaging, drusen, epidemiology, genetics
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5593-5601. doi:https://doi.org/10.1167/iovs.15-18816

Cornea

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome Open Access
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Nancy A. McNamara; Shaokui Ge; Salena M. Lee; Alison M. Enghauser; Lindsey Kuehl; Feeling Y.-T. Chen; Marianne Gallup; Robert L. McKown
Tags: cornea, dry eye syndromes, neurons, neuropathy, sjogren's syndrome
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5237-5243. doi:https://doi.org/10.1167/iovs.16-19309
Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus Open Access
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Natasha Pahuja; Nimisha R. Kumar; Rushad Shroff; Rohit Shetty; Rudy M. M. A. Nuijts; Anuprita Ghosh; Abhijit Sinha-Roy; Shyam S. Chaurasia; Rajiv R. Mohan; Arkasubhra Ghosh
Tags: cornea, gene expression, genes, keratoconus, retinal cone
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5372-5382. doi:https://doi.org/10.1167/iovs.16-19677
Friction Measurements on Contact Lenses in a Physiologically Relevant Environment: Effect of Testing Conditions on Friction Open Access
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Olof Sterner; Rudolf Aeschlimann; Stefan Zürcher; Kathrine Osborn Lorenz; Joseph Kakkassery; Nicholas D. Spencer; Samuele G. P. Tosatti
Tags: aging, contact lenses, friction, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5383-5392. doi:https://doi.org/10.1167/iovs.16-19713
MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells Open Access
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Morio Ueno; Kazuko Asada; Munetoyo Toda; Asako Hiraga; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: cornea, endothelial cells, micrornas, phenotype, small patella syndrome
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5509-5517. doi:https://doi.org/10.1167/iovs.16-19804
Melimine-Coated Antimicrobial Contact Lenses Reduce Microbial Keratitis in an Animal Model Open Access
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Debarun Dutta; Ajay K. Vijay; Naresh Kumar; Mark D. P. Willcox
Tags: animal model, antimicrobials, contact lenses, keratitis, lens (device)
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5616-5624. doi:https://doi.org/10.1167/iovs.16-19882

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

On the Maintenance of Normal Ocular Dominance and a Possible Mechanism Underlying Refractive Adaptation Open Access
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Jiawei Zhou; Lixia Feng; Huimin Lin; Robert F. Hess
Tags: balance, device, equilibrium, eye, ocular dominance, anisometropia
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5181-5185. doi:https://doi.org/10.1167/iovs.16-19696
Extraocular Muscle Compartments in Superior Oblique Palsy Open Access
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Soh Youn Suh; Robert A. Clark; Alan Le; Joseph L. Demer
Tags: fourth cranial nerve palsy, magnetic resonance imaging, muscle, muscle of orbit, paralysis
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5535-5540. doi:https://doi.org/10.1167/iovs.16-20172
Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons Open Access
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Andrea B. Agarwal; Cheng-Yuan Feng; Amy L. Altick; David R. Quilici; Dan Wen; L. Alan Johnson; Christopher S. von Bartheld
Tags: gene expression, muscle, muscle of orbit, polymerase chain reaction, proteins
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5576-5585. doi:https://doi.org/10.1167/iovs.16-20294
Assessing Suppression in Amblyopic Children With a Dichoptic Eye Chart Open Access
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Eileen E. Birch; Sarah E. Morale; Reed M. Jost; Angie De La Cruz; Krista R. Kelly; Yi-Zhong Wang; Peter J. Bex
Tags: amblyopia, child, eye charts, visual acuity, equilibrium
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5649-5654. doi:https://doi.org/10.1167/iovs.16-19986
The Relationship Between Fusion, Suppression, and Diplopia in Normal and Amblyopic Vision Open Access
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Daniel P. Spiegel; Alex S. Baldwin; Robert F. Hess
Tags: amblyopia, diplopia, eye, vision, health disparity
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5810-5817. doi:https://doi.org/10.1167/iovs.16-20438
Prolongation of Relaxation Time in Extraocular Muscles With Brain Derived Neurotrophic Factor in Adult Rabbit Open Access
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Krysta R. Nelson; Shanlee M. Stevens; Linda K. McLoon
Tags: adult, brain-derived neurotrophic factor, muscle of orbit, oryctolagus cuniculus, muscle
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5834-5842. doi:https://doi.org/10.1167/iovs.16-19679

Genetics

A Novel Method Combining Vitreous Aspiration and Intravitreal AAV2/8 Injection Results in Retina-Wide Transduction in Adult Mice Open Access
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Romain Da Costa; Carsten Röger; Jasmin Segelken; Maya Barben; Christian Grimm; John Neidhardt
Tags: endotracheal aspiration, injections, mice, pulmonary aspiration, retina
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5326-5334. doi:https://doi.org/10.1167/iovs.16-19701
Genotype-Phenotype Correlation for TGFBI Corneal Dystrophies Identifies p.(G623D) as a Novel Cause of Epithelial Basement Membrane Dystrophy Open Access
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Cerys J. Evans; Alice E. Davidson; Nicole Carnt; Karla E. Rojas López; Neyme Veli; Caroline M. Thaung; Stephen J. Tuft; Alison J. Hardcastle
Tags: basement membrane, epithelium, genotype, hereditary corneal dystrophy, mutation
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5407-5414. doi:https://doi.org/10.1167/iovs.16-19818
Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes Open Access
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Chloe Y. Y. Cheung; Elaine Y. L. Hui; Chi-Ho Lee; Kelvin H. M. Kwok; Rita A. Gangwani; Kenneth K. W. Li; Jeffrey C. W. Chan; Yu-Cho Woo; Wing-Sun Chow; Michele M. A. Yuen; Rachel L. C. Wong; Carol H. Y. Fong; Aimin Xu; David S. H. Wong; Pak-Chung Sham; Karen S. L. Lam
Tags: chinese (other dialects), chinese people, diabetes mellitus, type 2, diabetic retinopathy, genetics
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5518-5524. doi:https://doi.org/10.1167/iovs.16-20094
Association of ABCG1 With Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese Open Access
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Li Ma; Ke Liu; Motokazu Tsujikawa; Haoyu Chen; Marten E. Brelen; Vesta C. K. Chan; Timothy Y. Y. Lai; Kaori Sayanagi; Chicako Hara; Noriyasu Hashida; Pancy O. S. Tam; Alvin L. Young; Weiqi Chen; Kohji Nishida; Chi Pui Pang; Li Jia Chen
Tags: chinese (other dialects), chinese people, cohort studies, exudative age-related macular degeneration, japanese
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5758-5763. doi:https://doi.org/10.1167/iovs.16-20175

Glaucoma

Lentiviral Delivery of Small Hairpin RNA Targeting Connective Tissue Growth Factor Blocks Profibrotic Signaling in Tenon's Capsule Fibroblasts Open Access
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Dawei Lei; Changgui Dong; William Ka Kei Wu; Aimeng Dong; Tingting Li; Matthew T. V. Chan; Xinrong Zhou; Huiping Yuan
Tags: connective tissue growth factor, rna, fibroblasts, tenon's capsule
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5171-5180. doi:https://doi.org/10.1167/iovs.16-19480
An In Vitro Perfusion System to Enhance Outflow Studies in Mouse Eyes Open Access
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Krishnakumar Kizhatil; Arthur Chlebowski; Nicholas G. Tolman; Nelson F. Freeburg; Margaret M. Ryan; Nicholas N. Shaw; Alexander D. M. Kokini; Jeffrey K. Marchant; Simon W. M. John
Tags: eye, mice, perfusion
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5207-5215. doi:https://doi.org/10.1167/iovs.16-19481
Biometric Factors Associated With Acute Primary Angle Closure: Comparison of the Affected and Fellow Eye Open Access
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Eray Atalay; Monisha E. Nongpiur; Mani Baskaran; Sourabh Sharma; Shamira A. Perera; Tin Aung
Tags: biometry, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5320-5325. doi:https://doi.org/10.1167/iovs.16-20006
Comprehensive Three-Dimensional Analysis of the Neuroretinal Rim in Glaucoma Using High-Density Spectral-Domain Optical Coherence Tomography Volume Scans Open Access
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Edem Tsikata; Ramon Lee; Eric Shieh; Huseyin Simavli; Christian J. Que; Rong Guo; Ziad Khoueir; Johannes de Boer; Teresa C. Chen
Tags: glaucoma, neuroretinal rim, retinal nerve fiber layer, spectral domain-optical coherence tomography, volume
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5498-5508. doi:https://doi.org/10.1167/iovs.16-19802
Longitudinal Changes in Optic Nerve Head Blood Flow in Normal Rats Evaluated by Laser Speckle Flowgraphy Open Access
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Yasushi Wada; Tomomi Higashide; Atsushi Nagata; Kazuhisa Sugiyama
Tags: lasers, optic disk, rats, vascular flow
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5568-5575. doi:https://doi.org/10.1167/iovs.16-19945
Lack of Visual Field Improvement After Initiation of Intraocular Pressure Reducing Treatment in the Early Manifest Glaucoma Trial Open Access
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Boel Bengtsson; Anders Heijl
Tags: did not receive therapy or drug, glaucoma, intraocular pressure, visual fields, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5611-5615. doi:https://doi.org/10.1167/iovs.16-19389
Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data Open Access
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David Fleischman; Amanda K. Bicket; Sandra S. Stinnett; John P. Berdahl; Jost B. Jonas; Ning Li Wang; Michael P. Fautsch; R. Rand Allingham
Tags: beijing, cerebrospinal fluid pressure, datasets, diagnostic spinal puncture, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5625-5630. doi:https://doi.org/10.1167/iovs.16-20119
Effect of Restricting Perimetry Testing Algorithms to Reliable Sensitivities on Test-Retest Variability Open Access
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Stuart K. Gardiner; Steven L. Mansberger
Tags: perimetry, heterogeneity of variance, visual fields
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5631-5636. doi:https://doi.org/10.1167/iovs.16-20053
Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration Open Access
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Gema Rebolleda; Beatriz Puerto; Victoria de Juan; Marta Gómez-Mariscal; Francisco José Muñoz-Negrete; Alfonso Casado
Tags: exudative age-related macular degeneration, injections, intraocular pressure, optic disk
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5688-5695. doi:https://doi.org/10.1167/iovs.16-20111
Retinal and Macular Ganglion Cell Count Estimated With Optical Coherence Tomography RTVUE-100 as a Candidate Biomarker for Glaucoma Open Access
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Teresa Rolle; Laura Dallorto; Beatrice Bonetti
Tags: biological markers, cell count, ganglia, glaucoma, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5772-5779. doi:https://doi.org/10.1167/iovs.15-18882
In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements Open Access
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Xiaofei Wang; Meghna R. Beotra; Tin Aung Tun; Mani Baskaran; Shamira Perera; Tin Aung; Nicholas G. Strouthidis; Dan Milea; Michaël J. A. Girard
Tags: eye, eye movement, gaze, intraocular pressure, optic disk
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5825-5833. doi:https://doi.org/10.1167/iovs.16-20560

Immunology and Microbiology

Paucibacterial Microbiome and Resident DNA Virome of the Healthy Conjunctiva Open Access
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Thuy Doan; Lakshmi Akileswaran; Dallin Andersen; Benjamin Johnson; Narae Ko; Angira Shrestha; Valery Shestopalov; Cecilia S. Lee; Aaron Y. Lee; Russell N. Van Gelder
Tags: conjunctiva, dna, dna, ribosomal, internship and residency, medical residencies
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5116-5126. doi:https://doi.org/10.1167/iovs.16-19803
Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis Open Access
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Xue Li; Xiaoxiao Lu; Deming Sun; Xilian Wang; Liyuan Yang; Shaozhen Zhao; Hong Nian; Ruihua Wei
Tags: autoimmunity, dacryoadenitis, lymphocytes, oryctolagus cuniculus, mesenchymal stem cells
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5161-5170. doi:https://doi.org/10.1167/iovs.15-17824
Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis Open Access
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Sandamali A. Ekanayaka; Sharon A. McClellan; Ronald P. Barrett; Shikhil Kharotia; Linda D. Hazlett
Tags: bone plates, glycyrrhizic acid, hmgb1 protein, infections, keratitis
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5799-5809. doi:https://doi.org/10.1167/iovs.16-20103

Lens

In Vivo Brillouin Analysis of the Aging Crystalline Lens Open Access
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Sebastien Besner; Giuliano Scarcelli; Roberto Pineda; Seok-Hyun Yun
Tags: lens (device), lens, crystalline, aging
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5093-5100. doi:https://doi.org/10.1167/iovs.16-20143
Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens Open Access
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Nefeli Slavi; Zhen Wang; Lucas Harvey; Kevin L. Schey; Miduturu Srinivas
Tags: lens, crystalline, cytokinesis, lens (device), cytoplasm, gap junction protein
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5714-5722. doi:https://doi.org/10.1167/iovs.16-19698
β-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells Open Access
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Aftab Taiyab; Anna Korol; Paula A. Deschamps; Judith A. West-Mays
Tags: epithelial to mesenchymal transition, lens (device), lens, crystalline, signal transduction, lens epithelial cell
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5736-5747. doi:https://doi.org/10.1167/iovs.16-20162

Low Vision

Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Microperimetry Open Access
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Jonathan Denniss; Andrew T. Astle
Tags: gaze, heterogeneity of variance, perimetry, visual fields, fovea centralis
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5449-5456. doi:https://doi.org/10.1167/iovs.16-20222

Multidisciplinary Ophthalmic Imaging

Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy Open Access
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Dina El-Fayoumi; Nashwa M. Badr Eldine; Amanne F. Esmael; Dalia Ghalwash; Hend M. Soliman
Tags: child, diabetes mellitus, type 1, ganglia, retinal diseases, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5355-5360. doi:https://doi.org/10.1167/iovs.16-19988
Optical Detection of Early Damage in Retinal Ganglion Cells in a Mouse Model of Partial Optic Nerve Crush Injury Open Access
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Ji Yi; Zhen Puyang; Liang Feng; Lian Duan; Peiji Liang; Vadim Backman; Xiaorong Liu; Hao F. Zhang
Tags: crushing injuries, electroretinography, mice, optic nerve, optics
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5665-5671. doi:https://doi.org/10.1167/iovs.16-19955
Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography Open Access
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Glenn Yiu; Vivian S. Vuong; Sharon Oltjen; David Cunefare; Sina Farsiu; Laura Garzel; Jeffrey Roberts; Sara M. Thomasy
Tags: diagnostic imaging, eye, language morphology, macaca mulatta, melanocytes
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5764-5771. doi:https://doi.org/10.1167/iovs.16-20070

Nantotechnology and Regenerative Medicine

Regeneration of Corneal Epithelium With Dental Pulp Stem Cells Using a Contact Lens Delivery System Open Access
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Evgeny Kushnerev; Susan G. Shawcross; Shankari Sothirachagan; Fiona Carley; Arun Brahma; Julian M. Yates; M. Chantal Hillarby
Tags: capillary leak syndrome, contact lenses, cornea, corneal epithelium, de lange syndrome
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5192-5199. doi:https://doi.org/10.1167/iovs.15-17953

Physiology and Pharmacology

Melanopsin Phototransduction Contributes to Light-Evoked Choroidal Expansion and Rod L-Type Calcium Channel Function In Vivo Open Access
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Bruce A. Berkowitz; Tiffany Schmidt; Robert H. Podolsky; Robin Roberts
Tags: calcium channels, l-type, choroid, magnetic resonance imaging, melanopsin, mice
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5314-5319. doi:https://doi.org/10.1167/iovs.16-20186
Measurements of Retinal Perfusion Using Laser Speckle Flowgraphy and Doppler Optical Coherence Tomography Open Access
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Nikolaus Luft; Piotr A. Wozniak; Gerold C. Aschinger; Klemens Fondi; Ahmed M. Bata; René M. Werkmeister; Doreen Schmidl; Katarzyna J. Witkowska; Matthias Bolz; Gerhard Garhöfer; Leopold Schmetterer
Tags: lasers, optical coherence tomography, perfusion, vascular flow, fluid flow
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5417-5425. doi:https://doi.org/10.1167/iovs.16-19896
TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles Open Access
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Mary K. McGahon; José A. Fernández; Durga P. Dash; Jon McKee; David A. Simpson; Alex V. Zholos; J. Graham McGeown; Tim M. Curtis
Tags: arteriole, cations, constriction procedure, hypotonicity
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5637-5647. doi:https://doi.org/10.1167/iovs.16-20279
Factors Associated With Choroidal Blood Flow Regulation in Healthy Young Subjects Open Access
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Doreen Schmidl; Leopold Schmetterer; Katarzyna J. Witkowska; Alexandra Rauch; René M. Werkmeister; Gerhard Garhöfer; Alina Popa-Cherecheanu
Tags: exercise, isometric, fluid flow, intraocular pressure, regulation, vascular flow
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5705-5713. doi:https://doi.org/10.1167/iovs.16-20225

Retina

Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy Open Access
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Miao Zhang; Thomas S. Hwang; Changlei Dongye; David J. Wilson; David Huang; Yali Jia
Tags: angiogram, diabetic retinopathy, optical coherence tomography, retinal ischemia, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5101-5106. doi:https://doi.org/10.1167/iovs.16-19776
Carbonic Anhydrase Inhibitors for the Treatment of Cystic Macular Lesions in Children With X-Linked Juvenile Retinoschisis Open Access
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Sanne K. Verbakel; Johannes P. H. van de Ven; Linda M. P. Le Blanc; Joannes M. M. Groenewoud; Eiko K. de Jong; B. Jeroen Klevering; Carel B. Hoyng
Tags: carbonic anhydrase inhibitors, child, cysts, x-linked retinoschisis, catheter-related infections
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5143-5147. doi:https://doi.org/10.1167/iovs.16-20078
Progression of Late-Onset Stargardt Disease Open Access
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Stanley Lambertus; Moritz Lindner; Nathalie M. Bax; Matthias M. Mauschitz; Jennifer Nadal; Matthias Schmid; Steffen Schmitz-Valckenberg; Anneke I. den Hollander; Bernhard H. F. Weber; Frank G. Holz; Gert Jan van der Wilt; Monika Fleckenstein; Carel B. Hoyng; for the Foveal sparing Atrophy Study Team (FAST)
Tags: atrophy, cohort studies, eye, stargardt's disease, visual acuity
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5186-5191. doi:https://doi.org/10.1167/iovs.16-19833
Improved Automated Detection of Diabetic Retinopathy on a Publicly Available Dataset Through Integration of Deep Learning Open Access
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Michael David Abràmoff; Yiyue Lou; Ali Erginay; Warren Clarida; Ryan Amelon; James C. Folk; Meindert Niemeijer
Tags: diabetic retinopathy, learning, reference standards
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5200-5206. doi:https://doi.org/10.1167/iovs.16-19964
Oxygen Saturation of Retinal Vessels in All Stages of Diabetic Retinopathy and Correlation to Ultra-Wide Field Fluorescein Angiography Open Access
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Abhilash Guduru; Teresa G. Martz; Alexa Waters; Abhijit V. Kshirsagar; Seema Garg
Tags: diabetic retinopathy, fluorescein angiography, ischemia, oximetry, oxygen saturation measurement
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5278-5284. doi:https://doi.org/10.1167/iovs.16-20190
Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Laser-Induced Choroidal Neovascularization in Mice Open Access
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Daisuke Ozone; Takeshi Mizutani; Miho Nozaki; Masaharu Ohbayashi; Norio Hasegawa; Aki Kato; Tsutomu Yasukawa; Yuichiro Ogura
Tags: alteplase, choroidal neovascularization, lasers, mice, angiogenesis inhibitors
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5348-5354. doi:https://doi.org/10.1167/iovs.16-19617
Homozygosity for a Recessive Loss-of-Function Mutation of the NRL Gene Is Associated With a Variant of Enhanced S-Cone Syndrome Open Access
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Hadas Newman; Sergiu C. Blumen; Itzhak Braverman; Rana Hanna; Beatrice Tiosano; Ido Perlman; Tamar Ben-Yosef
Tags: electroretinography, genes, homozygote, mutation, retinal cone
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5361-5371. doi:https://doi.org/10.1167/iovs.16-19505
The Systemic Blood Pressure and Oxygen Saturation in Retinal Arterioles Predict the Effect of Intravitreal Anti-VEGF Treatment on Diabetic Maculopathy Open Access
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Toke Bek; Christina Mørup Jørgensen
Tags: anti-vascular endothelial growth factor therapy, arterial pressure, arteriole, diabetes mellitus, macular disorders
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5429-5434. doi:https://doi.org/10.1167/iovs.16-20305
Assessment of Retinotopic Rod Photoreceptor Function Using a Dark-Adapted Chromatic Perimeter in Intermediate Age-Related Macular Degeneration Open Access
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Rogan G. Fraser; Rose Tan; Lauren N. Ayton; Emily Caruso; Robyn H. Guymer; Chi D. Luu
Tags: age-related macular degeneration, eye, perimetry, rod photoreceptors, bleach
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5436-5442. doi:https://doi.org/10.1167/iovs.16-19295
Macular Inner Retinal Layer Thickening and Outer Retinal Layer Damage Correlate With Visual Acuity During Remission in Behcet's Disease Open Access
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Dan Cheng; Yuqin Wang; Shenghai Huang; Qiuyan Wu; Qi Chen; Meixiao Shen; Fan Lu
Tags: behcet syndrome, disease remission, visual acuity, spectral domain-optical coherence tomography, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5470-5478. doi:https://doi.org/10.1167/iovs.16-19568
Associations Between Retinal Pigment Epithelium and Drusen Volume Changes During the Lifecycle of Large Drusenoid Pigment Epithelial Detachments Open Access
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Chandrakumar Balaratnasingam; Lawrence A. Yannuzzi; Christine A. Curcio; William H. Morgan; Giuseppe Querques; Vittorio Capuano; Eric Souied; Jesse Jung; K. Bailey Freund
Tags: drusen, epithelium, parent's evaluation of developmental status, pigment, retinal pigment epithelium
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5479-5489. doi:https://doi.org/10.1167/iovs.16-19816
Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis Open Access
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Xin Zhong; Bogale Aredo; Yi Ding; Kaiyan Zhang; Cynthia X. Zhao; Rafael L. Ufret-Vincenty
Tags: apoptosis, fluorescein, mice, oxidative stress, retinal degeneration
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5558-5567. doi:https://doi.org/10.1167/iovs.16-19965
The Effects of Diabetic Retinopathy Stage and Light Flicker on Inner Retinal Oxygen Extraction Fraction Open Access
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Anthony E. Felder; Justin Wanek; Norman P. Blair; Charlotte E. Joslin; Katherine C. Brewer; Felix Y. Chau; Jennifer I. Lim; Yannek I. Leiderman; Mahnaz Shahidi
Tags: photopsia, diabetic retinopathy, oxygen extraction
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5586-5592. doi:https://doi.org/10.1167/iovs.16-20048
Retinal Hemodynamics Seen on Optical Coherence Tomography Angiography Before and After Treatment of Retinal Vein Occlusion Open Access
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Norihiro Suzuki; Yoshio Hirano; Taneto Tomiyasu; Yuya Esaki; Akiyoshi Uemura; Tsutomu Yasukawa; Munenori Yoshida; Yuichiro Ogura
Tags: angiogram, eye, hemodynamics, optical coherence tomography, retinal vein occlusion
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5681-5687. doi:https://doi.org/10.1167/iovs-16-20648
Retinal Capillary Density and Foveal Avascular Zone Area Are Age-Dependent: Quantitative Analysis Using Optical Coherence Tomography Angiography Open Access
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Nicholas A. Iafe; Nopasak Phasukkijwatana; Xuejing Chen; David Sarraf
Tags: angiogram, blood capillaries, eye, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5780-5787. doi:https://doi.org/10.1167/iovs.16-20045
Asymmetrical Functional Deficits of ON and OFF Retinal Processing in the mdx3Cv Mouse Model of Duchenne Muscular Dystrophy Open Access
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Tina I. Tsai; Mirella Telles Salgueiro Barboni; Balázs Vince Nagy; Michel J. Roux; Alvaro Rendon; Dora Fix Ventura; Jan Kremers
Tags: duchenne's muscular dystrophy, electroretinography, erg protein, human, mice, pathophysiology
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5788-5798. doi:https://doi.org/10.1167/iovs.16-19432
Cerebral Small Vessel Disease in Branch Retinal Artery Occlusion Open Access
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Kwan Hyuk Cho; Chi Kyung Kim; Se Joon Woo; Kyu Hyung Park; Sang Jun Park
Tags: brain mri, branch retinal artery occlusion, cerebral small vessel diseases, embolism, brain
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5818-5824. doi:https://doi.org/10.1167/iovs.16-20106

Retinal Cell Biology

Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish Open Access
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Christopher J. Sifuentes; Jung-Woong Kim; Anand Swaroop; Pamela A. Raymond
Tags: gene expression profiling, genes, neuroglia, stem cells, zebrafish
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5148-5160. doi:https://doi.org/10.1167/iovs.16-19973
The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions Open Access
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Jacey H. Ma; Joshua J. Wang; Junhua Li; Bruce A. Pfeffer; Yiming Zhong; Sarah X. Zhang
Tags: regulation, tight junctions, retinal pigment cell, retinal pigment epithelium, proteins
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5244-5252. doi:https://doi.org/10.1167/iovs.16-19232
Loss of Axin2 Causes Ocular Defects During Mouse Eye Development Open Access
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Ashley Alldredge; Sabine Fuhrmann
Tags: embryo, eye, mice, optic cup, retina
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5253-5262. doi:https://doi.org/10.1167/iovs.15-18599
Remote Ischemic Preconditioning Protects Retinal Photoreceptors: Evidence From a Rat Model of Light-Induced Photoreceptor Degeneration Open Access
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Alice Brandli; Daniel M. Johnstone; Jonathan Stone
Tags: brain-derived neurotrophic factor, ischemia, ischemic preconditioning, photoreceptors, proteins
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5302-5313. doi:https://doi.org/10.1167/iovs.16-19361
Down-Regulation of RNA 3′-Terminal Phosphate Cyclase Attenuates Toll-Like Receptor 3-Mediated Axonal Loss in the Retina and Optic Nerve Open Access
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Shravan K. Chintala; Naveena Daram
Tags: optic nerve, retina, ribavirin, rna, rna, small interfering
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5338-5347. doi:https://doi.org/10.1167/iovs.16-19799
Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 Endonuclease Open Access
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Glenn Yiu; Eric Tieu; Anthony T. Nguyen; Brittany Wong; Zeljka Smit-McBride
Tags: endonuclease, genome, vascular endothelial growth factor a, retinal pigment cell, crispr-cas9
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5490-5497. doi:https://doi.org/10.1167/iovs.16-20296
Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration Open Access
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Haibo Wang; Xiaokun Han; Eric Kunz; M. Elizabeth Hartnett
Tags: choroidal neovascularization, chronic exertional compartment syndrome, endothelial cells, exudative age-related macular degeneration, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5525-5534. doi:https://doi.org/10.1167/iovs.16-19691
The Role of DNA Methylation in the Metabolic Memory Phenomenon Associated With the Continued Progression of Diabetic Retinopathy Open Access
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Manish Mishra; Renu A. Kowluru
Tags: diabetes mellitus, diabetic retinopathy, dna, dna methylation, glucose
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5748-5757. doi:https://doi.org/10.1167/iovs.16-19759

Visual Neuroscience

Is Suppression Just Normal Dichoptic Masking? Suprathreshold Considerations Open Access
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Alexandre Reynaud; Robert F. Hess
Tags: amblyopia, contrast sensitivity, eye, perceptual masking
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5107-5115. doi:https://doi.org/10.1167/iovs.16-19682
Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration Open Access
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Felix P. Aplin; Erica L. Fletcher; Chi D. Luu; Kirstan A. Vessey; Penelope J. Allen; Robyn H. Guymer; Robert K. Shepherd; Mohit N. Shivdasani
Tags: cats, eye, retinal degeneration, retina, injections
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5216-5229. doi:https://doi.org/10.1167/iovs.16-19926
The Effects of Short-Term Light Adaptation on the Human Post-Illumination Pupil Response Open Access
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Daniel S. Joyce; Beatrix Feigl; Andrew J. Zele
Tags: constriction procedure, light, lighting, melanopsin, pupil reaction
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5672-5680. doi:https://doi.org/10.1167/iovs.16-19934

Visual Psychophysics and Physiological Optics

Anterior Corneal, Posterior Corneal, and Lenticular Contributions to Ocular Aberrations Open Access
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David A. Atchison; Marwan Suheimat; Ankit Mathur; Lucas J. Lister; Jos Rozema
Tags: cornea, eye
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5263-5270. doi:https://doi.org/10.1167/iovs.16-20067
Degradation of Visual Performance With Increasing Levels of Retinal Stray Light Open Access
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Marrie van der Mooren; Robert Rosén; Luuk Franssen; Linda Lundström; Patricia Piers
Tags: cataract, contrast sensitivity, glare, vision
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5443-5448. doi:https://doi.org/10.1167/iovs.15-18514
The Effect of Light Level and Small Pupils on Presbyopic Reading Performance Open Access
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Renfeng Xu; Daniel Gil; Mohammed Dibas; William Hare; Arthur Bradley
Tags: miosis disorder, reading (activity), pupil
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5656-5664. doi:https://doi.org/10.1167/iovs.16-20008
Visual Contrast Sensitivity in Early-Stage Parkinson's Disease Open Access
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Wendy Ming; Dimitrios J. Palidis; Miriam Spering; Martin J. McKeown
Tags: contrast sensitivity, parkinson disease, eye movement
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5696-5704. doi:https://doi.org/10.1167/iovs.16-20025

Perspective

Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye Open Access
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Perry Rosenthal; David Borsook; Eric A. Moulton
Tags: cornea, eye, nerve injuries, pain
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5285-5287. doi:https://doi.org/10.1167/iovs.16-20557

Research Opportunities

Report From the NEI/FDA Diabetic Retinopathy Clinical Trial Design and Endpoints Workshop Open Access
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Prashant Nair; Lloyd Paul Aiello; Thomas W. Gardner; Lee M. Jampol; Frederick L. Ferris III
Tags: diabetic retinopathy, surrogate endpoints, united states food and drug administration, anti-vascular endothelial growth factor therapy, diabetes mellitus, type 2
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5127-5142. doi:https://doi.org/10.1167/iovs.16-20356

Letters to the Editor

Comments on Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma Open Access
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Junhong Jiang; Cong Ye; Yuan Bo Liang
Tags: glaucoma, visual fields
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5271. doi:https://doi.org/10.1167/iovs.16-20386
Author Response: Comments on Evaluation of Central and Peripheral Visual Field Concordance in Glaucoma Open Access
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Jamie L. Odden; Aleksandra Mihailovic; Michael V. Boland; David S. Friedman; Sheila K. West; Pradeep Y. Ramulu
Tags: glaucoma, visual fields
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5272. doi:https://doi.org/10.1167/iovs.16-20697
Possibility of Cytoplasmic Transportation Between Donor–Host Cell Following Photoreceptor Transplantation Open Access
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Chen Liang; JunJun Zhang; Danian Chen
Tags: cytoplasm, donors, photoreceptors, transplantation, transportation
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5335. doi:https://doi.org/10.1167/iovs.16-20257
Author Response: Possibility of Cytoplasmic Transportation Between Donor–Host Cell Following Photoreceptor Transplantation Open Access
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Tiago Santos-Ferreira; Manuela Völkner; Oliver Borsch; Jochen Haas; Peter Cimalla; Praveen Vasudevan; Peter Carmeliet; Denis Corbeil; Stylianos Michalakis; Edmund Koch; Mike O Karl; Marius Ader
Tags: cytoplasm, donors, photoreceptors, transplantation, transportation
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5336-5337. doi:https://doi.org/10.1167/iovs.16-20687
Relationship of Goblet Cell Density and Glaucoma Filtration Surgery Outcome Open Access
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Wenbin Huang; Xiulan Zhang
Tags: filtering surgery, glaucoma, goblet cells
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5405. doi:https://doi.org/10.1167/iovs.16-20234
Author Response: In Vivo Goblet Cell Density as a Potential Indicator of Glaucoma Filtration Surgery Outcome Open Access
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Luca Agnifili; Vincenzo Fasanella
Tags: filtering surgery, glaucoma, goblet cells
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5406. doi:https://doi.org/10.1167/iovs.16-20662
Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1 Open Access
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Richard A. Bone; John T. Landrum
Tags: contrast sensitivity, macular pigment, retinal diseases
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5415. doi:https://doi.org/10.1167/iovs.16-20295
Author Response: Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1 Open Access
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John M. Nolan; Rebecca Power; Jim Stringham; Jessica Dennison; Jim Stack; David Kelly; Rachel Moran; Kwadwo O. Akuffo; Laura Corcoran; Stephen Beatty
Tags: contrast sensitivity, macular pigment, retinal diseases
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5416. doi:https://doi.org/10.1167/iovs.16-20498
The Glymphatic System: A New Player in Ocular Diseases? Open Access
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Peter Wostyn; Veva De Groot; Debby Van Dam; Kurt Audenaert; Peter Paul De Deyn; Hanspeter Esriel Killer
Tags: eye diseases
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5426-5427. doi:https://doi.org/10.1167/iovs.16-20262
“Black Holes” and the Ocular Glymphatic System: Author Response to “The Glymphatic System: A New Player in Ocular Diseases?” Open Access
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Alastair K. Denniston; Pearse A. Keane
Tags: eye diseases
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5428. doi:https://doi.org/10.1167/iovs.16-20479
The Influence of Age on Crystalline Lens Power Calculations Open Access
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Jos J. Rozema; David A. Atchison
Tags: lens, crystalline
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5435. doi:https://doi.org/10.1167/iovs.16-20444

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5556. doi:https://doi.org/10.1167/iovs.15-17091a
Erratum Open Access
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Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5557. doi:https://doi.org/10.1167/iovs.10-6827a
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