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Research Highlight

Congenital Cataracts: Classification and Association With Anterior Segment Abnormalities Open Access
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Manuel B. Datiles; J. Fielding Hejtmancik
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6396. doi:https://doi.org/10.1167/iovs.16-21074
Diurnal Fluctuation of Intraocular Pressure Open Access
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Paul L. Kaufman
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6427. doi:https://doi.org/10.1167/iovs.16-20997

Anatomy and Pathology/Oncology

Genome-Wide Scleral Micro- and Messenger-RNA Regulation During Myopia Development in the Mouse Open Access
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Ravikanth Metlapally; Han Na Park; Ranjay Chakraborty; Kevin K. Wang; Christopher C. Tan; Jacob G. Light; Machelle T. Pardue; Christine F. Wildsoet
Tags: mice, micrornas, myopia, rna, messenger, sclera
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6089-6097. doi:https://doi.org/10.1167/iovs.16-19563
The Targetable Epigenetic Tumor Protein EZH2 is Enriched in Intraocular Medulloepithelioma Open Access
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Sarah E. Avedschmidt; Anna M. Stagner; Ralph C. Eagle, Jr.; George J. Harocopos; Yali Dou; Rajesh C. Rao
Tags: epigenetics, ezh2 gene, neoplasms, proteins
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6242-6246. doi:https://doi.org/10.1167/iovs.16-20463

Biochemistry and Molecular Biology

DNA Duplex-Based Photodynamic Molecular Beacon for Targeted Killing of Retinoblastoma Cell Open Access
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Yanchun Wei; Cuixia Lu; Qun Chen; Da Xing
Tags: dna, killing, mdm4 gene, retinoblastoma, rna, messenger
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6011-6019. doi:https://doi.org/10.1167/iovs.15-18723

Clinical and Epidemiologic Research

Cataract Surgical Rate and Socioeconomics: A Global Study Open Access
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Wei Wang; William Yan; Kathy Fotis; Noela M. Prasad; Van Charles Lansingh; Hugh R. Taylor; Robert P. Finger; Damian Facciolo; Mingguang He
Tags: cataract, socioeconomic factors, surgical procedures, operative, economics, cataract surgery
Investigative Ophthalmology & Visual Science January 2017, Vol.57, 5872-5881. doi:https://doi.org/10.1167/iovs.16-19894
Six-Year Incidence of Blindness and Visual Impairment in Kenya: The Nakuru Eye Disease Cohort Study Open Access
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Andrew Bastawrous; Wanjiku Mathenge; Kevin Wing; Hillary Rono; Michael Gichangi; Helen A. Weiss; David Macleod; Allen Foster; Matthew J. Burton; Hannah Kuper
Tags: blindness, cohort studies, eye diseases, incidence, visual impairment
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5974-5983. doi:https://doi.org/10.1167/iovs.16-19835
While We Waited: Incidence and Predictors of Falls in Older Adults With Cataract Open Access
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Anna Palagyi; Peter McCluskey; Andrew White; Kris Rogers; Lynn Meuleners; Jonathon Q. Ng; Nigel Morlet; Lisa Keay
Tags: cataract, cataract surgery, elderly fall, incidence, fall risks
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6003-6010. doi:https://doi.org/10.1167/iovs.16-20582
External Validation of the Liverpool Uveal Melanoma Prognosticator Online Open Access
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Sarah W. DeParis; Azzam Taktak; Antonio Eleuteri; Wayne Enanoria; Heinrich Heimann; Sarah E. Coupland; Bertil Damato
Tags: cohort studies, neoplasms, uveal melanoma, mortality, neoplasm metastasis
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6116-6122. doi:https://doi.org/10.1167/iovs.16-19654
Age-Specific Prevalence of Visual Impairment and Refractive Error in Children Aged 3–10 Years in Shanghai, China Open Access
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Yingyan Ma; Xiaomei Qu; Xiaofeng Zhu; Xun Xu; Jianfeng Zhu; Padmaja Sankaridurg; Senlin Lin; Lina Lu; Rong Zhao; Ling Wang; Huijing Shi; Hui Tan; Xiaofang You; Hong Yuan; Sifei Sun; Mingjin Wang; Xiangui He; Haidong Zou; Nathan Congdon
Tags: child, china, myopia, prevalence, refractive errors
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6188-6196. doi:https://doi.org/10.1167/iovs.16-20243
Global Patterns in Health Burden of Uncorrected Refractive Error Open Access
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Lixia Lou; Chunlei Yao; Yanhua Jin; Victor Perez; Juan Ye
Tags: disability-adjusted life years, health, refractive errors, socioeconomic factors
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6271-6277. doi:https://doi.org/10.1167/iovs.16-20242
Feasibility of Macular Integrity Assessment (MAIA) Microperimetry in Children: Sensitivity, Reliability, and Fixation Stability in Healthy Observers Open Access
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Pete R. Jones; Narmella Yasoubi; Marko Nardini; Gary S. Rubin
Tags: adult, child, personal integrity, reliability
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6349-6359. doi:https://doi.org/10.1167/iovs.16-20037

Cornea

Administration of Menadione, Vitamin K3, Ameliorates Off-Target Effects on Corneal Epithelial Wound Healing Due to Receptor Tyrosine Kinase Inhibition Open Access
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Jamie S. Rush; David P. Bingaman; Paul G. Chaney; Martin B. Wax; Brian P. Ceresa
Tags: cornea, epithelium, receptor protein-tyrosine kinases, vitamin k 3, wound healing
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5864-5871. doi:https://doi.org/10.1167/iovs.16-19952
Antiapoptotic Effect of Acetylcholine in Fas-Induced Apoptosis in Human Keratocytes Open Access
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Marta Słoniecka; Ludvig J. Backman; Patrik Danielson
Tags: acetylcholine, apoptosis, keratocytes, tumor necrosis factor ligand superfamily member 6
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5892-5902. doi:https://doi.org/10.1167/iovs.16-19707
Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells Open Access
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Sébastien P. Gendron; Mathieu Thériault; Stéphanie Proulx; Isabelle Brunette; Patrick J. Rochette
Tags: cell culture techniques, cornea, dna, mitochondrial, endothelial cells, endothelium
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5926-5934. doi:https://doi.org/10.1167/iovs.16-20551
Integrin Alpha 9 Blockade Suppresses Lymphatic Valve Formation and Promotes Transplant Survival Open Access
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Gyeong Jin Kang; Tan Truong; Eric Huang; Valerie Su; Shaokui Ge; Lu Chen
Tags: integrins, keratoplasty, lymphatic vessels, transplantation, cornea
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5935-5939. doi:https://doi.org/10.1167/iovs.16-20130
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density Open Access
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Takefumi Yamaguchi; Kazunari Higa; Terumasa Suzuki; Naohiko Nakayama; Yukari Yagi-Yaguchi; Murat Dogru; Yoshiyuki Satake; Jun Shimazaki
Tags: aqueous humor, cytokine, eye, endothelial cells, bullous keratopathy
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5954-5962. doi:https://doi.org/10.1167/iovs.16-20187
Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion Open Access
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Min He; Thomas Storr-Paulsen; Annie L. Wang; Chiara E. Ghezzi; Siran Wang; Matthew Fullana; Dimitrios Karamichos; Tor P. Utheim; Rakibul Islam; May Griffith; M. Mirazul Islam; Robin R. Hodges; Gary E. Wnek; David L. Kaplan; Darlene A. Dartt
Tags: conjunctiva, extracellular matrix, goblet cells, hydrogels, polymers
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6134-6146. doi:https://doi.org/10.1167/iovs.16-20081
Activation of Rac1 and RhoA Preserve Corneal Endothelial Barrier Function Open Access
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María C. Ortega; Diana Santander-García; Beatriz Marcos-Ramiro; Susana Barroso; Susan Cox; Ignacio Jiménez-Alfaro; Jaime Millán
Tags: cornea, endothelium, rhoa gtp-binding protein, stress, osmosis
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6210-6222. doi:https://doi.org/10.1167/iovs.16-20031
Comparison of Patient-Specific Computational Modeling Predictions and Clinical Outcomes of LASIK for Myopia Open Access
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Ibrahim Seven; Ali Vahdati; Vinicius Silbiger De Stefano; Ronald R. Krueger; William J. Dupps, Jr
Tags: cornea, keratomileusis, laser in situ, myopia, patient-specific modeling, surgical procedures, operative
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6287-6297. doi:https://doi.org/10.1167/iovs.16-19948
Evaluation of Corneal Cross-Linking for Treatment of Fungal Keratitis: Using Confocal Laser Scanning Microscopy on an Ex Vivo Human Corneal Model Open Access
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Jawaher M. Alshehri; David Caballero-Lima; M. Chantal Hillarby; Susan G. Shawcross; Arun Brahma; Fiona Carley; Nick D. Read; Hema Radhakrishnan
Tags: cornea, corneal collagen cross-linking, fungal keratitis, microscopy, confocal scanning laser, corneal infections
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6367-6373. doi:https://doi.org/10.1167/iovs.16-20110
Transforming Growth Factor-β Signaling Cascade Induced by Mechanical Stimulation of Fluid Shear Stress in Cultured Corneal Epithelial Cells Open Access
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Tsugiaki Utsunomiya; Akihiro Ishibazawa; Taiji Nagaoka; Kazuomi Hanada; Harumasa Yokota; Nobuhito Ishii; Akitoshi Yoshida
Tags: corneal epithelial cells, corneal epithelium, shear stress, signal transduction, wound healing
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6382-6388. doi:https://doi.org/10.1167/iovs.16-20638
Safety and Efficacy Clinical Trials for SYL1001, a Novel Short Interfering RNA for the Treatment of Dry Eye Disease Open Access
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José Manuel Benitez-Del-Castillo; Javier Moreno-Montañés; Ignacio Jiménez-Alfaro; Francisco José Muñoz-Negrete; Krista Turman; Kadi Palumaa; Belén Sádaba; María Victoria González; Verónica Ruz; Beatriz Vargas; Covadonga Pañeda; Tamara Martínez; Anne-Marie Bleau; Ana Isabel Jimenez
Tags: dry eye syndromes, placebos, rna, rna, small interfering, safety
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6447-6454. doi:https://doi.org/10.1167/iovs.16-20303

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Longitudinal Evaluation of Eye Misalignment and Eye Movements Following Surgical Correction of Strabismus in Monkeys Open Access
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Mythri Pullela; Brittany A. Degler; David K. Coats; Vallabh E. Das
Tags: cercopithecidae, eye, eye movement, strabismus, surgical procedures, operative
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6040-6047. doi:https://doi.org/10.1167/iovs.16-20481
Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment Open Access
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Linda K. McLoon; Stephen P. Christiansen; Geoffrey M. Ghose; Vallabh E. Das; Michael J. Mustari
Tags: adult, cercopithecidae, eye, insulin-like growth factor i, muscle
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6070-6078. doi:https://doi.org/10.1167/iovs.16-19739

Genetics

The Spectrum of CHM Gene Mutations in Choroideremia and Their Relationship to Clinical Phenotype Open Access
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Matthew P. Simunovic; Jasleen K. Jolly; Kanmin Xue; Thomas L. Edwards; Markus Groppe; Susan M. Downes; Robert E. MacLaren
Tags: choroideremia, mutation, phenotype
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6033-6039. doi:https://doi.org/10.1167/iovs.16-20230
Progression Rate From Intermediate to Advanced Age-Related Macular Degeneration Is Correlated With the Number of Risk Alleles at the CFH Locus Open Access
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Rebecca J. Sardell; Patrice J. Persad; Samuel S. Pan; Patrice Whitehead; Larry D. Adams; Reneé A. Laux; Jorge A. Fortun; Milam A. Brantley, Jr; Jaclyn L. Kovach; Stephen G. Schwartz; Anita Agarwal; Jonathan L. Haines; William K. Scott; Margaret A. Pericak-Vance
Tags: age-related macular degeneration, alleles, genetic risk, choroidal neovascularization, genotype
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6107-6115. doi:https://doi.org/10.1167/iovs.16-19519
Mutations in AGBL5, Encoding α-Tubulin Deglutamylase, Are Associated With Autosomal Recessive Retinitis Pigmentosa Open Access
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Galuh D. N. Astuti; Gavin Arno; Sarah Hull; Laurence Pierrache; Hanka Venselaar; Keren Carss; F. Lucy Raymond; Rob W. J. Collin; Sultana M. H. Faradz; L. Ingeborgh van den Born; Andrew R. Webster; Frans P. M. Cremers
Tags: autosomal recessive inheritance, mutation, retinitis pigmentosa, tubulin, family
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6180-6187. doi:https://doi.org/10.1167/iovs.16-20148
Molecular Diagnosis of Inherited Retinal Diseases in Indigenous African Populations by Whole-Exome Sequencing Open Access
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Lisa Roberts; Rinki Ratnapriya; Morné du Plessis; Vijender Chaitankar; Raj S. Ramesar; Anand Swaroop
Tags: cohort studies, exome, family, molecular diagnostic techniques, retinal diseases
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6374-6381. doi:https://doi.org/10.1167/iovs.16-19785

Glaucoma

Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes Open Access
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Young Kook Kim; Byeong Wook Yoo; Jin Wook Jeoung; Hee Chan Kim; Hae Jin Kim; Ki Ho Park
Tags: eye, glaucoma, ganglia
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5856-5863. doi:https://doi.org/10.1167/iovs.16-20116
Diagnostic Performance of Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Glaucoma in an Elderly Population: The ALIENOR Study Open Access
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Cedric Schweitzer; Jean-Francois Korobelnik; Melanie Le Goff; Olivier Rahimian; Florence Malet; Marie-Benedicte Rougier; Marie-Noelle Delyfer; Jean-Francois Dartigues; Cecile Delcourt
Tags: glaucoma, older adult
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5882-5891. doi:https://doi.org/10.1167/iovs.16-20104
Quantitative Evaluation of Phase Retardation in Filtering Blebs Using Polarization-Sensitive Optical Coherence Tomography Open Access
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Shinichi Fukuda; Akari Fujita; Deepa Kasaragod; Yuta Ueno; Sujin Hoshi; Genichiro Kishino; Simone Beheregaray; Yoshiaki Yasuno; Tetsuro Oshika
Tags: blister, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5919-5925. doi:https://doi.org/10.1167/iovs.16-19548
Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice Open Access
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Lies De Groef; Lien Andries; Anuja Siwakoti; Emiel Geeraerts; Ilse Bollaerts; Lut Noterdaeme; Isabelle Etienne; Anna-Pia Papageorgiou; Ingeborg Stalmans; Johan Billen; Judith A. West-Mays; Lieve Moons
Tags: aqueous humor, collagen, gelatinase b, mice, knockout, trabecular meshwork
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5984-5995. doi:https://doi.org/10.1167/iovs.16-19734
In Vivo Distribution of Corneal Epithelial Dendritic Cells in Patients With Glaucoma Open Access
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Rodolfo Mastropasqua; Luca Agnifili; Vincenzo Fasanella; Andrea Lappa; Lorenza Brescia; Manuela Lanzini; Francesco Oddone; Paolo Perri; Leonardo Mastropasqua
Tags: cornea, dendritic cells, glaucoma, epithelium, dry eye syndromes
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5996-6002. doi:https://doi.org/10.1167/iovs.16-20333
Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork Open Access
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Ramesh B. Kasetti; Tien N. Phan; J. Cameron Millar; Gulab S. Zode
Tags: myoc gene, proteins, mice, fibronectins, extracellular matrix proteins
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6058-6069. doi:https://doi.org/10.1167/iovs.16-19610
Activity Limitation in Glaucoma: Objective Assessment by the Cambridge Glaucoma Visual Function Test Open Access
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Simon E. Skalicky; Colm McAlinden; Tasneem Khatib; Louise May Anthony; Sing Yue Sim; Keith R. Martin; Ivan Goldberg; Peter McCluskey
Tags: glaucoma, vision, validity of results
Investigative Ophthalmology & Visual Science December 2016, Vol.57, 6158-6166. doi:https://doi.org/10.1167/iovs.16-19458
Factors Influencing Lamina Cribrosa Microcapillary Hemodynamics and Oxygen Concentrations Open Access
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Thanadet Chuangsuwanich; K. Erik Birgersson; Alexandre Thiery; Sri Gowtham Thakku; Hwa Liang Leo; Michaël J. A. Girard
Tags: hemodynamics, oxygen, mass or substance concentration per volume, cribriform plate, vascular flow
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6167-6179. doi:https://doi.org/10.1167/iovs.16-20167
Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms Open Access
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Ruiyi Ren; Guorong Li; Thuy Duong Le; Casey Kopczynski; W. Daniel Stamer; Haiyan Gong
Tags: eye, perfusion
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6197-6209. doi:https://doi.org/10.1167/iovs.16-20189
OCT Angiography of the Peripapillary Retina in Primary Open-Angle Glaucoma Open Access
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Eun Ji Lee; Kyoung Min Lee; Seung Hyen Lee; Tae-Woo Kim
Tags: angiogram, open-angle glaucoma, retina, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6265-6270. doi:https://doi.org/10.1167/iovs.16-20287
Benefit of Measuring Anterior Segment Structures Using an Increased Number of Optical Coherence Tomography Images: The Chinese American Eye Study Open Access
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Benjamin Y. Xu; Paul Israelsen; Billy X. Pan; Dandan Wang; Xuejuan Jiang; Rohit Varma
Tags: chinese people, eye, optical coherence tomography, transient ischemic attack, sclera
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6313-6319. doi:https://doi.org/10.1167/iovs.16-19755
Do Intense Perimetric Stimuli Saturate the Healthy Visual System? Open Access
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Andrew J. Anderson; Allison M. McKendrick; Andrew Turpin
Tags: perimetry, visual system, ganglia, glaucoma, retinal ganglion cells
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6397-6404. doi:https://doi.org/10.1167/iovs.16-20004
Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure Open Access
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Sally Miller; Emma Leishman; Olivia Oehler; Laura Daily; Natalia Murataeva; Jim Wager-Miller; Heather Bradshaw; Alex Straiker
Tags: circadian rhythms, ethanolamines, intraocular pressure, lipids, polycystic liver disease
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6419-6426. doi:https://doi.org/10.1167/iovs.16-19437
Integrin α5β1 Inhibition by CLT-28643 Reduces Postoperative Wound Healing in a Mouse Model of Glaucoma Filtration Surgery Open Access
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Tine Van Bergen; Grit Zahn; Patrizia Caldirola; Mario Fsadni; Ninus Caram-Lelham; Evelien Vandewalle; Lieve Moons; Ingeborg Stalmans
Tags: blister, filtering surgery, glaucoma, glaucoma surgery, integrins
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6428-6439. doi:https://doi.org/10.1167/iovs.16-19751
Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity Open Access
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Takayuki Tsutsumi; Keiichiro Iwao; Hideki Hayashi; Tomoko Kirihara; Takahiro Kawaji; Toshihiro Inoue; Shinjiro Hino; Mitsuyoshi Nakao; Hidenobu Tanihara
Tags: neuroprotective effect, tranylcypromine, mitogen-activated protein kinase p38, retinal ganglion cells
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6461-6473. doi:https://doi.org/10.1167/iovs.16-19494

Immunology and Microbiology

IL-17A Promotes RANTES Expression, But Not IL-16, in Orbital Fibroblasts Via CD40-CD40L Combination in Thyroid-Associated Ophthalmopathy Open Access
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Sijie Fang; Yazhuo Huang; Sisi Zhong; Yidan Zhang; Xingtong Liu; Yang Wang; Ping Gu; Huifang Zhou; Xianqun Fan
Tags: cd40 ligand, fibroblasts, graves' ophthalmopathy, interleukin-16, interleukin-17
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6123-6133. doi:https://doi.org/10.1167/iovs.16-20199

Lens

A Novel Congenital Cataract Category System Based on Lens Opacity Locations and Relevant Anterior Segment Characteristics Open Access
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Haotian Lin; Duoru Lin; Zhenzhen Liu; Erping Long; Xiaohang Wu; Qianzhong Cao; Jingjing Chen; Zhuoling Lin; Xiaoyan Li; Li Zhang; Hui Chen; Xiayin Zhang; Jing Li; Weirong Chen; Yizhi Liu
Tags: cataract, congenital cataract, chief complaint
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6389-6395. doi:https://doi.org/10.1167/iovs.16-20280

Low Vision

One-Year Outcome of 49-Channel Suprachoroidal–Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa Open Access
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Takashi Fujikado; Motohiro Kamei; Hirokazu Sakaguchi; Hiroyuki Kanda; Takao Endo; Masakazu Hirota; Takeshi Morimoto; Kentaro Nishida; Haruhiko Kishima; Yasuo Terasawa; Koji Oosawa; Motoki Ozawa; Kohji Nishida
Tags: retinitis pigmentosa, surgical procedures, operative, accommodation phosphene
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6147-6157. doi:https://doi.org/10.1167/iovs.16-20367

Multidisciplinary Ophthalmic Imaging

Discriminant Function of Optical Coherence Tomography Angiography to Determine Disease Severity in Glaucoma Open Access
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Rajesh S. Kumar; Neha Anegondi; Rachana S. Chandapura; Suria Sudhakaran; Sujatha V. Kadambi; Harsha L. Rao; Tin Aung; Abhijit Sinha Roy
Tags: angiogram, glaucoma, optical coherence tomography, severity of illness, eye
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6079-6088. doi:https://doi.org/10.1167/iovs.16-19984
A Monte Carlo Analysis of Error Associated With Two-Wavelength Algorithms for Retinal Oximetry Open Access
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Daniel A. Rodriguez; T. Joshua Pfefer; Quanzeng Wang; Pedro F. Lopez; Jessica C. Ramella-Roman
Tags: calibration, diameter, oximetry, eye, melanins
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6474-6481. doi:https://doi.org/10.1167/iovs.16-20138

Retina

Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice Open Access
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Norman P. Blair; Justin Wanek; Anthony E. Felder; Katherine C. Brewer; Charlotte E. Joslin; Mahnaz Shahidi
Tags: diabetes mellitus, metabolism, mice, oxygen delivery, diagnostic imaging
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5903-5909. doi:https://doi.org/10.1167/iovs.16-20082
Evaluation of Choroidal Thickness in Children With Iron Deficiency Anemia Open Access
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Ali Simsek; Mehmet Tekin; Abdurrahman Bilen; Ayse Sevgi Karadag; Ibrahim Hakan Bucak; Mehmet Turgut
Tags: child, iron deficiency anemia
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5940-5944. doi:https://doi.org/10.1167/iovs.15-18713
The Ingenious Interactions Between Macrophages and Functionally Plastic Retinal Pigment Epithelium Cells Open Access
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Takahiro Yamawaki; Eiko Ito; Atsushi Mukai; Morio Ueno; Jun Yamada; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: coculture techniques, cytokine, interleukin-6, macrophages, massively-parallel genome sequencing
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5945-5953. doi:https://doi.org/10.1167/iovs.16-20604
The Effect on Retinal Structure and Function of 15 Specific ABCA4 Mutations: A Detailed Examination of 82 Hemizygous Patients Open Access
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Ana Fakin; Anthony G. Robson; John (Pei-Wen) Chiang; Kaoru Fujinami; Anthony T. Moore; Michel Michaelides; Graham E. Holder; Andrew R. Webster
Tags: mutation, hemizygosity, alleles, severity of illness, electroretinography
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5963-5973. doi:https://doi.org/10.1167/iovs.16-20446
Retinal Microvasculature Alteration in High Myopia Open Access
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Ye Yang; Jianhua Wang; Hong Jiang; Xiaoling Yang; Limiao Feng; Liang Hu; Liang Wang; Fan Lu; Meixiao Shen
Tags: eye, microvascular network, myopia, retinal vasculature, microvessels
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6020-6030. doi:https://doi.org/10.1167/iovs.16-19542
Increased Plasma cGMP in a Family With Autosomal Recessive Retinitis Pigmentosa Due to Homozygous Mutations in the PDE6A Gene Open Access
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Ulrika Kjellström; Patricia Veiga-Crespo; Sten Andréasson; Per Ekström
Tags: cyclic gmp, family, genes, homozygote, mutation
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6048-6057. doi:https://doi.org/10.1167/iovs.16-19861
Changes in Blood Flow on Optic Nerve Head After Vitrectomy for Rhegmatogenous Retinal Detachment Open Access
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Takeshi Iwase; Misato Kobayashi; Kentaro Yamamoto; Kosei Yanagida; Eimei Ra; Hiroko Terasaki
Tags: eye, optic disk, radiation recall dermatitis, retinal detachment, rhegmatogenous retinal detachment
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6223-6233. doi:https://doi.org/10.1167/iovs.16-20577
Association of Circulating Markers With Outcome Parameters in the Bevacizumab and Ranibizumab in Diabetic Macular Edema Trial Open Access
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Ward Fickweiler; Ingeborg Klaassen; Ilse M. C. Vogels; Johanna M. M. Hooymans; Bruce H. R. Wolffenbuttel; Leonoor I. Los; Reinier O. Schlingemann; for the BRDME Research Group
Tags: bevacizumab, biological markers, diabetic macular edema, ranibizumab, rhodopsin
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6234-6241. doi:https://doi.org/10.1167/iovs.16-20157
Characteristics of Retinal Neovascularization in Proliferative Diabetic Retinopathy Imaged by Optical Coherence Tomography Angiography Open Access
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Akihiro Ishibazawa; Taiji Nagaoka; Harumasa Yokota; Atsushi Takahashi; Tsuneaki Omae; Young-Seok Song; Tatsuhisa Takahashi; Akitoshi Yoshida
Tags: angiogram, diabetes mellitus, optical coherence tomography, proliferative diabetic retinopathy, retinal neovascularization
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6247-6255. doi:https://doi.org/10.1167/iovs.16-20210
Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging Open Access
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Fang Zheng; Giovanni Gregori; Karen B. Schaal; Andrew D. Legarreta; Andrew R. Miller; Luiz Roisman; William J. Feuer; Philip J. Rosenfeld
Tags: age-related macular degeneration, nonexudative, diagnostic imaging, eye, maps, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6256-6264. doi:https://doi.org/10.1167/iovs.16-20161
Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor–Dependent Death of Retinal Endothelial Cells Open Access
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Jose-Andres C. Portillo; Yalitza Lopez Corcino; George R. Dubyak; Timothy S. Kern; Shigemi Matsuyama; Carlos S. Subauste
Tags: cd40 antigens, endothelial cells, ligation, diabetes mellitus
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6278-6286. doi:https://doi.org/10.1167/iovs.16-20301
Functional Reading Independence (FRI) Index: A New Patient-Reported Outcome Measure for Patients With Geographic Atrophy Open Access
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Miriam Kimel; Nancy Kline Leidy; Elizabeth Tschosik; Chantal Dolan; Eric H. Souied; Rohit Varma; Neil M. Bressler
Tags: atrophy, interviews, patient self-report, reading (activity), validity of results
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6298. doi:https://doi.org/10.1167/iovs.16-20361
OCT Angiography–Based Detection and Quantification of the Neovascular Network in Exudative AMD Open Access
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Moritz Lindner; Petra P. Fang; Julia S. Steinberg; Niklas Domdei; Maximilian Pfau; Tim U. Krohne; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein
Tags: angiogram, eye, neovascularization, pathologic
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6342-6348. doi:https://doi.org/10.1167/iovs.16-19741
Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function Open Access
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Lisa Toto; Enrico Borrelli; Rodolfo Mastropasqua; Alfonso Senatore; Luca Di Antonio; Marta Di Nicola; Paolo Carpineto; Leonardo Mastropasqua
Tags: blood capillaries, ganglia, macular function, retinitis pigmentosa, electroretinography
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6360-6366. doi:https://doi.org/10.1167/iovs.16-20544
Choroidal Thickness Influences Near-Infrared Reflectance Intensity in Eyes With Geographic Atrophy Due To Age-Related Macular Degeneration Open Access
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Rosa Dolz-Marco; Orly Gal-Or; K. Bailey Freund
Tags: age-related macular degeneration, atrophy, eye, spectral domain-optical coherence tomography, diagnostic imaging
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6440-6446. doi:https://doi.org/10.1167/iovs.16-20265
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy Open Access
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Joana Tavares Ferreira; Marta Alves; Arnaldo Dias-Santos; Lívio Costa; Bruno Oliveira Santos; João Paulo Cunha; Ana Luísa Papoila; Luís Abegão Pinto
Tags: diabetes mellitus, diabetic retinopathy, nerve degeneration
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6455-6460. doi:https://doi.org/10.1167/iovs.16-20215

Retinal Cell Biology

Distribution and Quantification of Choroidal Macrophages in Human Eyes With Age-Related Macular Degeneration Open Access
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D. Scott McLeod; Imran Bhutto; Malia M. Edwards; Rachel E. Silver; Johanna M. Seddon; Gerard A. Lutty
Tags: age-related macular degeneration, choroid, eye, hla-dr antigens, macrophages
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5843-5855. doi:https://doi.org/10.1167/iovs.16-20049
Senescence Increases Choroidal Endothelial Stiffness and Susceptibility to Complement Injury: Implications for Choriocapillaris Loss in AMD Open Access
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Andrea P. Cabrera; Arun Bhaskaran; Jun Xu; Xiao Yang; Harry A. Scott; Umar Mohideen; Kaustabh Ghosh
Tags: aging, complement membrane attack complex, complement system proteins, disease susceptibility, electroconvulsive therapy
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 5910-5918. doi:https://doi.org/10.1167/iovs.16-19727
Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush Open Access
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Giuseppe Rovere; Francisco M. Nadal-Nicolás; Paloma Sobrado-Calvo; David García-Bernal; Maria Paz Villegas-Pérez; Manuel Vidal-Sanz; Marta Agudo-Barriuso
Tags: bromfenac, gliosis, inflammation, optic nerve, retina
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6098-6106. doi:https://doi.org/10.1167/iovs.16-20425
Vitreal Cytokine Profile Differences Between Eyes With Epiretinal Membranes or Macular Holes Open Access
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Souska Zandi; Christoph Tappeiner; Isabel B. Pfister; Alain Despont; Robert Rieben; Justus G. Garweg
Tags: cytokine, epiretinal membrane, macular holes, eye
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6320-6326. doi:https://doi.org/10.1167/iovs.16-20657
Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa Open Access
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Paul A. Nakamura; Shibing Tang; Andy A. Shimchuk; Sheng Ding; Thomas A. Reh
Tags: dimethyl sulfoxide, mice, photoreceptors, retina, retinitis pigmentosa
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6407-6415. doi:https://doi.org/10.1167/iovs.16-20177

Visual Neuroscience

Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram Open Access
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Nina Milosavljevic; Annette E. Allen; Jasmina Cehajic-Kapetanovic; Robert J. Lucas
Tags: electroretinography, mice
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6305-6312. doi:https://doi.org/10.1167/iovs.16-20448
Electrically Evoked Responses in the Rabbit Cortex Induced by Current Steering With Penetrating Optic Nerve Electrodes Open Access
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Yan Yan; Yiliang Lu; Menghui Li; Zengguang Ma; Pengjia Cao; Yao Chen; Xiaodong Sun; Xinyu Chai; Qiushi Ren; Liming Li
Tags: optic nerve, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6327-6338. doi:https://doi.org/10.1167/iovs.15-17543

Letters to the Editor

Peripapillary Atrophy in Myopic Eyes: Comparison of Gamma to Beta Zone Ratio Between Those With and Without Glaucoma Open Access
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Izabela Almeida; Michele Ushida; Igor Lins; Diego Torres Dias; Tiago Santos Prata
Tags: atrophy, eye, glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6031. doi:https://doi.org/10.1167/iovs.16-20542
Author Response: Peripapillary Atrophy in Myopic Eyes: Comparison of Gamma to Beta Zone Ratio Between Those With and Without Glaucoma Open Access
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Jayme R. Vianna; Marcelo T. Nicolela
Tags: atrophy, eye, glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6032. doi:https://doi.org/10.1167/iovs.16-20901
A Meta-Analysis of Glaucoma Risk in Hyperlipidemic Individuals: A Critical Problem in Design Open Access
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In Cheol Hwang; Yong Joo Lee; Jeong Hun Bae
Tags: glaucoma, meta-analysis
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6339-6340. doi:https://doi.org/10.1167/iovs.16-20099
Author Response: A Meta-Analysis of Glaucoma Risk in Hyperlipidemic Individuals: A Critical Problem in Design Open Access
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Paul McCann; Ruth E. Hogg; Augusto Azuara-Blanco
Tags: glaucoma, meta-analysis
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6341. doi:https://doi.org/10.1167/iovs.16-20233
Comparison of Local Structure–Function Relationships and Dynamic Range in Glaucoma Open Access
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Shuichun Wang
Tags: dynamic range, glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6405. doi:https://doi.org/10.1167/iovs.16-20795
Author Response: Comparison of Local Structure–Function Relationships and Dynamic Range in Glaucoma Open Access
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Arezoo Miraftabi; Navid Amini; Esteban Morales; Sharon Henry; Fei Yu; Abdolmonem Afifi; Anne L. Coleman; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: dynamic range, glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6406. doi:https://doi.org/10.1167/iovs.16-20990
Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population Open Access
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Kazuhiko Mori; Masakazu Nakano; Yuichi Tokuda; Yoko Ikeda; Morio Ueno; Chie Sotozono; Shigeru Kinoshita; Kei Tashiro
Tags: cdkn2b gene, japanese, low tension glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6416-6417. doi:https://doi.org/10.1167/iovs.16-20417
Author Response: Stronger Association of CDKN2B-AS1 Variants in Female Normal-Tension Glaucoma Patients in a Japanese Population Open Access
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Kathryn P. Burdon; Soo K. Ng; Stuart MacGregor; Jamie E. Craig
Tags: cdkn2b gene, japanese, low tension glaucoma
Investigative Ophthalmology & Visual Science November 2016, Vol.57, 6418. doi:https://doi.org/10.1167/iovs.16-20917
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