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Anatomy and Pathology/Oncology

Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation Open Access
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Aleksandar Stojic; Richard Fairless; Susanne C. Beck; Vithiyanjali Sothilingam; Petra Weissgerber; Ulrich Wissenbach; Valerie Gimmy; Mathias W. Seeliger; Veit Flockerzi; Ricarda Diem; Sarah K. Williams
Tags: mice, mutation, optic neuritis, retinal degeneration, autoimmunity
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 318-328. doi:https://doi.org/10.1167/iovs.16-20419
Altered Anterior Segment Biometric Parameters in Mice Deficient in SPARC Open Access
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Henrietta Ho; Hla M. Htoon; Gary Hin-Fai Yam; Li Zhen Toh; Nyein Chan Lwin; Stephanie Chu; Ying Shi Lee; Tina T. Wong; Li-Fong Seet
Tags: anterior chamber of eye, biometry, mice, sparc study, immune reconstitution inflammatory syndrome
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 386-393. doi:https://doi.org/10.1167/iovs.16-20261

Biochemistry and Molecular Biology

The Effect of Phospholipids on Tear Film Lipid Layer Surface Activity Open Access
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Antti H. Rantamäki; Juha M. Holopainen *
Tags: lipids, phospholipids, tear film finding, water
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 149-154. doi:https://doi.org/10.1167/iovs.16-20468
HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration Open Access
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Gian Marco Tosi; Elena Caldi; Giovanni Neri; Elisabetta Nuti; Davide Marigliani; Stefano Baiocchi; Claudio Traversi; Gabriele Cevenini; Antonio Tarantello; Fiorella Fusco; Federica Nardi; Maurizio Orlandini; Federico Galvagni
Tags: aqueous humor, exudative age-related macular degeneration, htra1 gene
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 162-167. doi:https://doi.org/10.1167/iovs.16-20922
β2–Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression Open Access
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Jeremy A. Lavine; Mitra Farnoodian; Shoujian Wang; Soesiawati R. Darjatmoko; Lynda S. Wright; David M. Gamm; Michael S. Ip; Christine M. Sorenson; Nader Sheibani
Tags: adrenergic receptor, choroidal neovascularization, interleukin-6, vascular endothelial growth factor a, retinal pigment cell
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 299-308. doi:https://doi.org/10.1167/iovs.16-20204
Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming Open Access
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Ying-Hsuan Shih; Monte J. Radeke; Carolyn M. Radeke; Pete J. Coffey
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 430-441. doi:https://doi.org/10.1167/iovs.16-20018
Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Open Access
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Nina Riddell; Sheila G. Crewther
Tags: genes, genome-wide association study, myopia, proteins, proteomics
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 660-669. doi:https://doi.org/10.1167/iovs.16-20618

Clinical and Epidemiologic Research

Visual Perception and Reading: New Clues to Patterns of Dysfunction Across Multiple Visual Channels in Developmental Dyslexia Open Access
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Ana Pina Rodrigues; José Rebola; Helena Jorge; Maria José Ribeiro; Marcelino Pereira; Marieke van Asselen; Miguel Castelo-Branco
Tags: dyslexia, reading (activity), reading disorder, developmental, visual perception, pathophysiology
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 309-317. doi:https://doi.org/10.1167/iovs.16-20095
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms of Eye Fatigue Open Access
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Jonathan B. Lin; Blair W. Gerratt; Carl J. Bassi; Rajendra S. Apte
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 442-447. doi:https://doi.org/10.1167/iovs.16-20663

Cornea

Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis Open Access
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Wei-Sheng Chen*; Zhiyi Cao; Hakon Leffler; Ulf J. Nilsson; Noorjahan Panjwani
Tags: cornea, corneal neovascularization, fibrosis, galectin 3, angiogenesis
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 9-20. doi:https://doi.org/10.1167/iovs.16-20009
Exposure Stress Induces Reversible Corneal Graft Opacity in Recipients With Herpes Simplex Virus-1 Infections Open Access
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Alexander M. Rowe; Hongmin Yun; Robert L. Hendricks
Tags: beds, cornea, human herpesvirus 1, infections, keratoplasty
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 35-41. doi:https://doi.org/10.1167/iovs.16-19673
Bacterial Coaggregation Among the Most Commonly Isolated Bacteria From Contact Lens Cases Open Access
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Ananya Datta; Fiona Stapleton; Mark D. P. Willcox
Tags: bacteria, contact lens storage case
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 50-58. doi:https://doi.org/10.1167/iovs.16-20593
Angiopoietin-2 Blockade Promotes Survival of Corneal Transplants Open Access
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Liwei Zhang; Guangyu Li; Roberto Sessa; Gyeong Jin Kang; Meng Shi; Shaokui Ge; Anna Jiang Gong; Ying Wen; Sudhakar Chintharlapalli; Lu Chen
Tags: angiopoietins, cornea, keratoplasty, rejection (psychology), transplantation
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 79-86. doi:https://doi.org/10.1167/iovs.16-20485
Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye Open Access
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Chengxin Zhou; Marie-Claude Robert; Vassiliki Kapoulea; Fengyang Lei; Anna M. Stagner; Frederick A. Jakobiec; Claes H. Dohlman; Eleftherios I. Paschalis
Tags: alkalies, burns, cornea, eye, infliximab
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 96-105. doi:https://doi.org/10.1167/iovs.16-20339
Estimating the Osmolarities of Tears During Evaporation Through the “Eyes” of the Corneal Nerves Open Access
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Harumitsu Hirata; Kamila Mizerska; Valentina Dallacasagrande; Mark I. Rosenblatt
Tags: cornea, evaporation, eye, mosmol, neurons
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 168-178. doi:https://doi.org/10.1167/iovs.16-20501
Biomechanical Strengthening of the Human Cornea Induced by Nanoplatform-Based Transepithelial Riboflavin/UV-A Corneal Cross-Linking Open Access
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Cristina Labate; Marco Lombardo; Giuseppe Lombardo; Maria Penelope De Santo
Tags: cornea, corneal collagen cross-linking, riboflavin, ultraviolet a radiation, body tissue
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 179-184. doi:https://doi.org/10.1167/iovs.16-20813
Immune Cells on the Corneal Endothelium of an Allogeneic Corneal Transplantation Rabbit Model Open Access
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Elena Koudouna; Naoki Okumura; Yugo Okazaki; Shinichiro Nakano; Ryota Inoue; Nigel J. Fullwood; Junko Hori; Shigeru Kinoshita; Noriko Koizumi
Tags: corneal endothelium, keratoplasty, oryctolagus cuniculus, descemet stripping endothelial keratoplasty, tissue transplants
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 242-251. doi:https://doi.org/10.1167/iovs.16-20019
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy Open Access
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Eric D. Wieben; Ross A. Aleff; Xiaojia Tang; Malinda L. Butz; Krishna R. Kalari; Edward W. Highsmith; Jin Jen; George Vasmatzis; Sanjay V. Patel; Leo J. Maguire; Keith H. Baratz; Michael P. Fautsch
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 343-352. doi:https://doi.org/10.1167/iovs.16-20900
The Effects of Nonporous Silica Nanoparticles on Cultured Human Keratocytes Open Access
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Bora Yim; Joo-Hee Park; Hyejoong Jeong; Jinkee Hong; Young-Joo Shin; Roy S. Chuck; Choul Yong Park
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 362-371. doi:https://doi.org/10.1167/iovs.16-20603
Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome Open Access
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Mihir Shah; Maria C. Edman; Srikanth Reddy Janga; Frances Yarber; Zhen Meng; Wannita Klinngam; Jonathan Bushman; Tao Ma; Siyu Liu; Stan Louie; Arjun Mehta; Chuanqing Ding; J. Andrew MacKay; Sarah F. Hamm-Alvarez
Tags: eyedrops, inflammation, mice, rapamycin, dacryoadenitis
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 372-385. doi:https://doi.org/10.1167/iovs.16-19159
Functional Properties of Sensory Nerve Terminals of the Mouse Cornea Open Access
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Omar González-González; Federico Bech; Juana Gallar; Jesús Merayo-Lloves; Carlos Belmonte
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 404-415. doi:https://doi.org/10.1167/iovs.16-20033
Preventing Corneal Calcification Associated With Xylazine for Longitudinal Optical Coherence Tomography in Young Rodents Open Access
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Tianwei Ellen Zhou; Diane N. Sayah; Baraa Noueihed; Javier Mazzaferri; Santiago Costantino; Isabelle Brunette; Sylvain Chemtob
Tags: calcification, cornea, rats, rodentia, xylazine
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 461-469. doi:https://doi.org/10.1167/iovs.16-20526
Factors Associated With Corneal Deformation Responses Measured With a Dynamic Scheimpflug Analyzer Open Access
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Atsuya Miki; Naoyuki Maeda; Yasushi Ikuno; Tomoko Asai; Chikako Hara; Kohji Nishida
Tags: cornea, intraocular pressure, eye
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 538-544. doi:https://doi.org/10.1167/iovs.16-21045
Antimicrobial Blue Light Therapy for Infectious Keratitis: Ex Vivo and In Vivo Studies Open Access
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Hong Zhu; Irene E. Kochevar; Irmgard Behlau; Jie Zhao; Fenghua Wang; Yucheng Wang; Xiaodong Sun; Michael R. Hamblin; Tianhong Dai
Tags: abetalipoproteinemia, antimicrobials, blue light, cornea, keratitis
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 586-593. doi:https://doi.org/10.1167/iovs.16-20272
Identification of Circulating Fibrocytes and Dendritic Derivatives in Corneal Endothelium of Patients With Fuchs' Dystrophy Open Access
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An-Katrien De Roo; Jasper Wouters; Olivier Govaere; Beatrijs Foets; Joost J. van den Oord
Tags: dendrites, endothelium, hereditary corneal dystrophy, corneal endothelium, language morphology
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 670-681. doi:https://doi.org/10.1167/iovs.16-20880

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Retinotopic to Spatiotopic Mapping in Blind Patients Implanted With the Argus II Retinal Prosthesis Open Access
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Avi Caspi; Arup Roy; Jessy D. Dorn; Robert J. Greenberg
Tags: eye, visual prosthesis, retina, pupil, brain
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 119-127. doi:https://doi.org/10.1167/iovs.16-20398
Effects of Pure Vergence Training on Initiation and Binocular Coordination of Saccades Open Access
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Aurélien Morize; Dominique Brémond-Gignac; François Daniel; Zoï Kapoula
Tags: rehabilitation, saccades
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 329-342. doi:https://doi.org/10.1167/iovs.16-19837
The Effect of Gaze Angle on Visual Acuity in Infantile Nystagmus Open Access
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Matt J. Dunn; Debbie Wiggins; J. Margaret Woodhouse; Tom H. Margrain; Christopher M. Harris; Jonathan T. Erichsen
Tags: gaze, pathologic nystagmus, visual acuity
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 642-650. doi:https://doi.org/10.1167/iovs.16-20370
Coordinated Control of Three-Dimensional Components of Smooth Pursuit to Rotating and Translating Textures Open Access
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Janick Edinger; Dinesh K. Pai; Miriam Spering
Tags: eye, musculoskeletal torsion, function, pursuit, smooth, saccades, torsion
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 698-707. doi:https://doi.org/10.1167/iovs.16-21038

Genetics

A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population Open Access
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Drew R. Nannini; Mina Torres; Yii-Der I. Chen; Kent D. Taylor; Jerome I. Rotter; Rohit Varma; Xiaoyi Gao
Tags: genome, genome-wide association study, hispanics or latinos, imputation, optic cup/disc ratio
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 87-95. doi:https://doi.org/10.1167/iovs.16-19891
Mutation Spectrum of the ABCA4 Gene in 335 Stargardt Disease Patients From a Multicenter German Cohort—Impact of Selected Deep Intronic Variants and Common SNPs Open Access
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Heidi L. Schulz; Felix Grassmann; Ulrich Kellner; Georg Spital; Klaus Rüther; Herbert Jägle; Karsten Hufendiek; Philipp Rating; Cord Huchzermeyer; Maria J. Baier; Bernhard H. F. Weber; Heidi Stöhr
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 394-403. doi:https://doi.org/10.1167/iovs.16-19936
Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease Open Access
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Xiu-Feng Huang; Jian-Yang Mao; Zhi-Qin Huang; Feng-Qin Rao; Fei-Fei Cheng; Fen-Fen Li; Qing-Feng Wang; Zi-Bing Jin
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 424-429. doi:https://doi.org/10.1167/iovs.16-20705
Novel PEX11B Mutations Extend the Peroxisome Biogenesis Disorder 14B Phenotypic Spectrum and Underscore Congenital Cataract as an Early Feature Open Access
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Rachel L. Taylor; Mark T. Handley; Sarah Waller; Christopher Campbell; Jill Urquhart; Alison M. Meynert; Jamie M. Ellingford; Deirdre Donnelly; Gisela Wilcox; I. Chris Lloyd; Helen Mundy; David R. FitzPatrick; Charu Deshpande; Jill Clayton-Smith; Graeme C. Black
Tags: congenital cataract, family, massively-parallel genome sequencing, mutation, peroxisome biogenesis disorder
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 594-603. doi:https://doi.org/10.1167/iovs.16-21026

Glaucoma

Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT Open Access
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Tin A. Tun; Mani Baskaran; Shayne S. Tan; Shamira A. Perera; Tin Aung; Rahat Husain
Tags: gonioscopy, optical coherence tomography, eye
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 59-64. doi:https://doi.org/10.1167/iovs.16-20886
Comparison of Aqueous Outflow Facility Measurement by Pneumatonography and Digital Schiøtz Tonography Open Access
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Arash Kazemi; Jay W. McLaren; Shuai-Chun Lin; Carol B. Toris; Vikas Gulati; Sayoko E. Moroi; Arthur J. Sit
Tags: body weight, eye, intraocular pressure, muscle rigidity, tonometers
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 204-210. doi:https://doi.org/10.1167/iovs.16-20754
A Mouse Model of Chronic Ocular Hypertension Induced by Circumlimbal Suture Open Access
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Hsin-Hua Liu; John G. Flanagan
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 353-361. doi:https://doi.org/10.1167/iovs.16-20576
Association of Plasma Complement C3 Levels With Primary Angle-Closure Glaucoma in Older Women Open Access
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Shengjie Li; Yuhong Chen; Mingxi Shao; Li Tang; Xinghuai Sun; Wenjun Cao
Tags: angle closure glaucoma, complement 3, complement system proteins, glaucoma, older adult
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 682-689. doi:https://doi.org/10.1167/iovs.16-20675
Discriminatory Power of Superficial Vessel Density and Prelaminar Vascular Flow Index in Eyes With Glaucoma and Ocular Hypertension and Normal Eyes Open Access
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Etsuo Chihara; Galina Dimitrova; Hiroyuki Amano; Tomoyuki Chihara
Tags: eye, glaucoma, ocular hypertension, vascular flow, open-angle glaucoma
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 690-697. doi:https://doi.org/10.1167/iovs.16-20709

Immunology and Microbiology

Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing Open Access
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Haikun Zhang; Fuxin Zhao; Diane S. Hutchinson; Wenfeng Sun; Nadim J. Ajami; Shujuan Lai; Matthew C. Wong; Joseph F. Petrosino; Jianhuo Fang; Jun Jiang; Wei Chen; Peter S. Reinach; Jia Qu; Changqing Zeng; Dake Zhang; Xiangtian Zhou
Tags: conjunctiva, contact lenses, contact lenses, hydrophilic, microbiome, orthokeratology contact lenses
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 128-136. doi:https://doi.org/10.1167/iovs.16-20231
Effect of Corneal Nerve Ablation on Immune Tolerance Induced by Corneal Allografts, Oral Immunization, or Anterior Chamber Injection of Antigens Open Access
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Juan Mo; Sudha Neelam; Jessamee Mellon; Joseph R. Brown; Jerry Y. Niederkorn
Tags: allografting, antigens, cornea, immunization, injections
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 137-148. doi:https://doi.org/10.1167/iovs.16-20601
Cytokine Profiles of Tear Fluid From Patients With Pediatric Lacrimal Duct Obstruction Open Access
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Nozomi Matsumura; Satoshi Goto; Eiichi Uchio; Kyoko Nakajima; Takeshi Fujita; Kazuaki Kadonosono
Tags: cytokine, lacrimal duct obstruction, pediatrics, interleukin-6
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 252-256. doi:https://doi.org/10.1167/iovs.16-20717
Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy Open Access
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Rebecca G. Edwards; Sarah J. Kopp; Igal Ifergan; Jr-Wen Shui; Mitchell Kronenberg; Stephen D. Miller; Richard Longnecker
Tags: cornea, human herpesvirus 1, infections, mice, nerve injuries
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 282-291. doi:https://doi.org/10.1167/iovs.16-20668
Association of High-Mobility Group Box-1 With Th Cell–Related Cytokines in the Vitreous of Ocular Sarcoidosis Patients Open Access
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Masaru Takeuchi; Manzo Taguchi; Tomohito Sato; Kyoko Karasawa; Yutaka Sakurai; Kohzou Harimoto; Masataka Ito
Tags: cytokine, hmgb1 protein, mobility, ocular sarcoidosis, sarcoidosis
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 528-537. doi:https://doi.org/10.1167/iovs.16-20324

Lens

Generation of Functional Lentoid Bodies From Human Induced Pluripotent Stem Cells Derived From Urinary Cells Open Access
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Qiuli Fu; Zhenwei Qin; Xiuming Jin; Lifang Zhang; Zhijian Chen; Jiliang He; Junfeng Ji; Ke Yao
Tags: crystallins, fried foods, lens (device), lens, crystalline, pluripotent stem cells
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 517-527. doi:https://doi.org/10.1167/iovs.16-20504
Proteomic Analysis of the Bovine and Human Ciliary Zonule Open Access
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Alicia De Maria; Phillip A. Wilmarth; Larry L. David; Steven Bassnett
Tags: cattle, proteins, suspensory ligament of lens, vitreous body, fibrillin-1
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 573-585. doi:https://doi.org/10.1167/iovs.16-20866

Multidisciplinary Ophthalmic Imaging

Evaluation of Therapeutic Tissue Crosslinking (TXL) for Myopia Using Second Harmonic Generation Signal Microscopy in Rabbit Sclera Open Access
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Mariya Zyablitskaya; Anna Takaoka; Emilia L. Munteanu; Takayuki Nagasaki; Stephen L. Trokel; David C. Paik
Tags: body tissue, harmonics, myopia, oryctolagus cuniculus, sclera
Investigative Ophthalmology & Visual Science August 2017, Vol.58, 21-29. doi:https://doi.org/10.1167/iovs.16-20241
Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy Open Access
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Robin Sharma; Christina Schwarz; Jennifer J. Hunter; Grazyna Palczewska; Krzysztof Palczewski; David R. Williams
Tags: diagnostic imaging, drug clearance, eye, kinetics, ophthalmoscopy
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 604-613. doi:https://doi.org/10.1167/iovs.16-20061

Physiology and Pharmacology

Glial Cell Contribution to Basal Vessel Diameter and Pressure-Initiated Vascular Responses in Rat Retina Open Access
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Hui Li; Bang V. Bui; Grant Cull; Fang Wang; Lin Wang
Tags: diameter, neuroglia, retina, intraocular pressure, eye
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 1-8. doi:https://doi.org/10.1167/iovs.16-20804
Origins of Pupillary Hippus in the Autonomic Nervous System Open Access
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Philip R. K. Turnbull; Nouzar Irani; Nicky Lim; John R. Phillips
Tags: eye, hippus, pupil, autonomic nervous system, tropicamide
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 197-203. doi:https://doi.org/10.1167/iovs.16-20785
Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells Open Access
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Juni Banerjee; Chi-Ting Leung; Ang Li; Kim Peterson-Yantorno; Huan Ouyang; W. Daniel Stamer; Mortimer M. Civan
Tags: cell volume, edema, hypotonicity, ionomycin, regulation
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 492-501. doi:https://doi.org/10.1167/iovs.16-20188
Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection Open Access
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Bryce Chiang; Ke Wang; C. Ross Ethier; Mark R. Prausnitz
Tags: drug clearance, fluorescein, injections, molecule, kinetics
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 545-554. doi:https://doi.org/10.1167/iovs.16-20679
Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations Open Access
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Bryce Chiang; Nitin Venugopal; Hans E. Grossniklaus; Jae Hwan Jung; Henry F. Edelhauser; Mark R. Prausnitz
Tags: injections, liquids, volume, kinetics
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 555-564. doi:https://doi.org/10.1167/iovs.16-20377
Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells Open Access
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Ruiping Gu; Boya Lei; Chen Jiang; Gezhi Xu
Tags: glucocorticoids, intercellular adhesion molecule 1, leucine zippers, monocyte chemoattractant protein-1, endothelial cells
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 631-641. doi:https://doi.org/10.1167/iovs.16-20933

Retina

Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occl... Open Access
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Khalil Ghasemi Falavarjani; Nicholas A. Iafe; Jean-Pierre Hubschman; Irena Tsui; Srinivas R. Sadda; David Sarraf
Tags: angiogram, anti-vascular endothelial growth factor therapy, diabetic macular edema, eye, intravitreal injections
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 30-34. doi:https://doi.org/10.1167/iovs.16-20579
High-Resolution Imaging of Intraretinal Structures in Active and Resolved Central Serous Chorioretinopathy Open Access
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Ryan N. Vogel; Christopher S. Langlo; Drew Scoles; Joseph Carroll; David V. Weinberg; Judy E. Kim
Tags: central serous chorioretinopathy, diagnostic imaging, photoreceptors, mosaicism, retina
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 42-49. doi:https://doi.org/10.1167/iovs.16-20351
The Effects of Metformin on Obesity-Induced Dysfunctional Retinas Open Access
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Andy Jeesu Kim; Janet Ya-An Chang; Liheng Shi; Richard Cheng-An Chang; Michael Lee Ko; Gladys Yi-Ping Ko
Tags: metformin, obesity, retina, diabetes mellitus, type 2, mice
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 106-118. doi:https://doi.org/10.1167/iovs.16-20691
Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy Open Access
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Galina Dimitrova; Etsuo Chihara; Hirokazu Takahashi; Hiroyuki Amano; Kazushiro Okazaki
Tags: angiogram, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, optical coherence tomography
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 190-196. doi:https://doi.org/10.1167/iovs.16-20531
Transcorneal Electrical Stimulation for Patients With Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Follow-up Study Over 1 Year Open Access
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Andreas Schatz; Johanna Pach; Mariya Gosheva; Lubka Naycheva; Gabriel Willmann; Barbara Wilhelm; Tobias Peters; Karl Ulrich Bartz-Schmidt; Eberhart Zrenner; André Messias; Florian Gekeler
Tags: electric stimulation, electroretinography, follow-up studies, retinal cone, retinitis pigmentosa
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 257-269. doi:https://doi.org/10.1167/iovs.16-19906
Intraocular Vascular Endothelial Growth Factor Levels in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration Open Access
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Masayuki Hata; Kenji Yamashiro; Sotaro Ooto; Akio Oishi; Hiroshi Tamura; Manabu Miyata; Naoko Ueda-Arakawa; Ayako Takahashi; Akitaka Tsujikawa; Nagahisa Yoshimura
Tags: exudative age-related macular degeneration, vascular endothelial growth factor a, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 292-298. doi:https://doi.org/10.1167/iovs.16-20967
ANRIL: A Regulator of VEGF in Diabetic Retinopathy Open Access
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Anu Alice Thomas; Biao Feng; Subrata Chakrabarti
Tags: diabetic retinopathy, glucose, vascular endothelial growth factor a, rna, up-regulation (physiology)
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 470-480. doi:https://doi.org/10.1167/iovs.16-20569
Pituitary Adenylate Cyclase-Activating Peptide (PACAP), a Novel Secretagogue, Regulates Secreted Morphogens in Newborn Rat Retina Open Access
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Monika Lakk; Viktoria Denes; Karmen Kovacs; Orsolya Hideg; Bence F. Szabo; Robert Gabriel
Tags: newborn, peptides, pituitary adenylate cyclase activating polypeptide, pituitary gland, retina
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 565-572. doi:https://doi.org/10.1167/iovs.16-20566
Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model Open Access
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Magdalene J. Seiler; Robert E. Lin; Bryce T. McLelland; Anuradha Mathur; Bin Lin; Jaclyn Sigman; Alexander T. De Guzman; Leonard M. Kitzes; Robert B. Aramant; Biju B. Thomas
Tags: rats, nude, transplantation, vision, immunologic deficiency syndromes, eye
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 614-630. doi:https://doi.org/10.1167/iovs.15-19028
Gli1 Expression in Human Epiretinal Membranes Open Access
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Sohee Jeon; Jiwon Baek; Won Ki Lee
Tags: epiretinal membrane, zinc finger protein gli1
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 651-659. doi:https://doi.org/10.1167/iovs.16-20409

Retinal Cell Biology

Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature Open Access
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Youde Jiang; Li Liu; Jena J. Steinle
Tags: endothelial cells, mice, proteins, retinal vasculature, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 185-189. doi:https://doi.org/10.1167/iovs.16-20412
Evaluation of the Surgical Device and Procedure for Extracellular Matrix–Scaffold–Supported Human iPSC–Derived Retinal Pigment Epithelium Cell Sheet Transplantation Open Access
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Hiroyuki Kamao; Michiko Mandai; Wataru Ohashi; Yasuhiko Hirami; Yasuo Kurimoto; Junichi Kiryu; Masayo Takahashi
Tags: retinal pigment cell, surgical instruments, surgical procedures, operative, tissue transplants, transplantation
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 211-220. doi:https://doi.org/10.1167/iovs.16-19778
Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Open Access
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Yosuke Nagasaka; Hiroki Kaneko; Fuxiang Ye; Shu Kachi; Tetsu Asami; Seiichi Kato; Kei Takayama; Shiang-Jyi Hwang; Keiko Kataoka; Hideyuki Shimizu; Takeshi Iwase; Yasuhito Funahashi; Akiko Higuchi; Takeshi Senga; Hiroko Terasaki
Tags: caveolins, epithelial to mesenchymal transition, vitreoretinopathy, proliferative, mice
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 221-229. doi:https://doi.org/10.1167/iovs.16-20513
BH4-Mediated Enhancement of Endothelial Nitric Oxide Synthase Activity Reduces Hyperoxia-Induced Endothelial Damage and Preserves Vascular Integrity in the Neonate Open Access
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Kevin S. Edgar; Orla M. Galvin; Anthony Collins; Zvonimir S. Katusic; Denise M. McDonald
Tags: hyperoxia, nitric oxide synthase, endothelium
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 230-241. doi:https://doi.org/10.1167/iovs.16-20523
Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa Open Access
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Raghavi Sudharsan; Kristina M. Simone; Nathan P. Anderson; Gustavo D. Aguirre; William A. Beltran
Tags: cell death, dog, domestic, light exposure, photoreceptors, retinal degeneration
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 270-281. doi:https://doi.org/10.1167/iovs.16-20749
The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival Open Access
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Emma M. Lessieur; Joseph Fogerty; Robert J. Gaivin; Ping Song; Brian D. Perkins
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 448-460. doi:https://doi.org/10.1167/iovs.16-20326

Visual Neuroscience

Assessment of Rod, Cone, and Intrinsically Photosensitive Retinal Ganglion Cell Contributions to the Canine Chromatic Pupillary Response Open Access
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Connie Y. Yeh; Kristin L. Koehl; Christine D. Harman; Simone Iwabe; José M. Guzman; Simon M. Petersen-Jones; Randy H. Kardon; András M. Komáromy
Tags: dog, domestic, pupil reaction, retinal cone, rod photoreceptors, pupillometry
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 65-78. doi:https://doi.org/10.1167/iovs.16-19865
The Pattern of Retinal Ganglion Cell Loss in OPA1-Related Autosomal Dominant Optic Atrophy Inferred From Temporal, Spatial, and Chromatic Sensitivity Losses Open Access
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Anna Majander; Catarina João; Andrew T. Rider; G. Bruce Henning; Marcela Votruba; Anthony T. Moore; Patrick Yu-Wai-Man; Andrew Stockman
Tags: dead on arrival, optic atrophy, autosomal dominant, retinal cone, visual impairment, contrast sensitivity
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 502-516. doi:https://doi.org/10.1167/iovs.16-20309

Visual Psychophysics and Physiological Optics

Spatial and Global Sensory Suppression Mapping Encompassing the Central 10° Field in Anisometropic Amblyopia Open Access
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Jingjing Li; Jinrong Li; Zidong Chen; Jing Liu; Junpeng Yuan; Xiaoxiao Cai; Daming Deng; Minbin Yu
Tags: amblyopia, anisometropic amblyopia, eye, filters, psychophysics
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 481-491. doi:https://doi.org/10.1167/iovs.16-20298

Perspective

Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/Limbal Epithelia Open Access
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Han Peng; Jong Kook Park; Robert M. Lavker
Tags: autophagy, cornea, eye
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 416-423. doi:https://doi.org/10.1167/iovs.16-21111

Letters to the Editor

Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies Open Access
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Jack C. M. Ng; Mavis M. Y. Fung; Henry H. L. Chan; Jimmy S. M. Lai
Tags: open-angle glaucoma, statins, meta-analysis
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 155-157. doi:https://doi.org/10.1167/iovs.16-21068
Author Response: Statin Use and Open-Angle Glaucoma: Evidence From Observational Studies Open Access
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Paul McCann; Ruth E. Hogg; Augusto Azuara-Blanco
Tags: open-angle glaucoma, statins
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 158-161. doi:https://doi.org/10.1167/iovs.16-21133
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