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Anatomy and Pathology/Oncology

Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation Open Access
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Aleksandar Stojic; Richard Fairless; Susanne C. Beck; Vithiyanjali Sothilingam; Petra Weissgerber; Ulrich Wissenbach; Valerie Gimmy; Mathias W. Seeliger; Veit Flockerzi; Ricarda Diem; Sarah K. Williams
Tags: autoimmunity, mice, mutation, optic neuritis, retinal degeneration
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 318-328. doi:10.1167/iovs.16-20419
Altered Anterior Segment Biometric Parameters in Mice Deficient in SPARC Open Access
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Henrietta Ho; Hla M. Htoon; Gary Hin-Fai Yam; Li Zhen Toh; Nyein Chan Lwin; Stephanie Chu; Ying Shi Lee; Tina T. Wong; Li-Fong Seet
Tags: anterior chamber of eye, biometry, immune reconstitution inflammatory syndrome, mice, sparc study
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 386-393. doi:10.1167/iovs.16-20261

Biochemistry and Molecular Biology

The Effect of Phospholipids on Tear Film Lipid Layer Surface Activity Open Access
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Antti H. Rantamäki; Juha M. Holopainen *
Tags: lipids, phospholipids, tear film finding, water
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 149-154. doi:10.1167/iovs.16-20468
HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration Open Access
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Gian Marco Tosi; Elena Caldi; Giovanni Neri; Elisabetta Nuti; Davide Marigliani; Stefano Baiocchi; Claudio Traversi; Gabriele Cevenini; Antonio Tarantello; Fiorella Fusco; Federica Nardi; Maurizio Orlandini; Federico Galvagni
Tags: aqueous humor, exudative age-related macular degeneration, htra1 gene
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 162-167. doi:10.1167/iovs.16-20922
β2–Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression Open Access
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Jeremy A. Lavine; Mitra Farnoodian; Shoujian Wang; Soesiawati R. Darjatmoko; Lynda S. Wright; David M. Gamm; Michael S. Ip; Christine M. Sorenson; Nader Sheibani
Tags: adrenergic receptor, choroidal neovascularization, interleukin-6, retinal pigment cell, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 299-308. doi:10.1167/iovs.16-20204
Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming Open Access
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Ying-Hsuan Shih; Monte J. Radeke; Carolyn M. Radeke; Pete J. Coffey
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 430-441. doi:10.1167/iovs.16-20018
Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Open Access
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Nina Riddell; Sheila G. Crewther
Tags: genes, genome-wide association study, myopia, proteins, proteomics
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 660-669. doi:10.1167/iovs.16-20618

Clinical and Epidemiologic Research

Visual Perception and Reading: New Clues to Patterns of Dysfunction Across Multiple Visual Channels in Developmental Dyslexia Open Access
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Ana Pina Rodrigues; José Rebola; Helena Jorge; Maria José Ribeiro; Marcelino Pereira; Marieke van Asselen; Miguel Castelo-Branco
Tags: dyslexia, pathophysiology, reading (activity), reading disorder, developmental, visual perception
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 309-317. doi:10.1167/iovs.16-20095
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms of Eye Fatigue Open Access
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Jonathan B. Lin; Blair W. Gerratt; Carl J. Bassi; Rajendra S. Apte
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 442-447. doi:10.1167/iovs.16-20663

Cornea

Galectin-3 Inhibition by a Small-Molecule Inhibitor Reduces Both Pathological Corneal Neovascularization and Fibrosis Open Access
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Wei-Sheng Chen*; Zhiyi Cao; Hakon Leffler; Ulf J. Nilsson; Noorjahan Panjwani
Tags: angiogenesis, cornea, corneal neovascularization, fibrosis, galectin 3
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 9-20. doi:10.1167/iovs.16-20009
Exposure Stress Induces Reversible Corneal Graft Opacity in Recipients With Herpes Simplex Virus-1 Infections Open Access
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Alexander M. Rowe; Hongmin Yun; Robert L. Hendricks
Tags: beds, cornea, human herpesvirus 1, infection, keratoplasty
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 35-41. doi:10.1167/iovs.16-19673
Bacterial Coaggregation Among the Most Commonly Isolated Bacteria From Contact Lens Cases Open Access
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Ananya Datta; Fiona Stapleton; Mark D. P. Willcox
Tags: bacteria, contact lens storage case
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 50-58. doi:10.1167/iovs.16-20593
Angiopoietin-2 Blockade Promotes Survival of Corneal Transplants Open Access
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Liwei Zhang; Guangyu Li; Roberto Sessa; Gyeong Jin Kang; Meng Shi; Shaokui Ge; Anna Jiang Gong; Ying Wen; Sudhakar Chintharlapalli; Lu Chen
Tags: angiopoietins, cornea, keratoplasty, rejection (psychology), transplantation
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 79-86. doi:10.1167/iovs.16-20485
Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye Open Access
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Chengxin Zhou; Marie-Claude Robert; Vassiliki Kapoulea; Fengyang Lei; Anna M. Stagner; Frederick A. Jakobiec; Claes H. Dohlman; Eleftherios I. Paschalis
Tags: alkalies, burns, cornea, eye, infliximab
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 96-105. doi:10.1167/iovs.16-20339
Estimating the Osmolarities of Tears During Evaporation Through the “Eyes” of the Corneal Nerves Open Access
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Harumitsu Hirata; Kamila Mizerska; Valentina Dallacasagrande; Mark I. Rosenblatt
Tags: cornea, evaporation, eye, mosmol, neurons
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 168-178. doi:10.1167/iovs.16-20501
Biomechanical Strengthening of the Human Cornea Induced by Nanoplatform-Based Transepithelial Riboflavin/UV-A Corneal Cross-Linking Open Access
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Cristina Labate; Marco Lombardo; Giuseppe Lombardo; Maria Penelope De Santo
Tags: body tissue, cornea, corneal collagen cross-linking, riboflavin, ultraviolet a radiation
Investigative Ophthalmology & Visual Science January 2017, Vol.58, 179-184. doi:10.1167/iovs.16-20813