Volume 58 Issue 2 | IOVS

Research Highlight

Drusen on Demand? Authors Describe a Novel Culture System for Generating subRPE Deposits Open Access

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Robert F. Mullins

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 720. doi:https://doi.org/10.1167/iovs.17-21419

Ex Vivo Imaging of the Murine Optic Nerve Head Open Access

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Tatjana C. Jakobs

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 734. doi:https://doi.org/10.1167/iovs.17-21422

Biochemistry and Molecular Biology

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1^delTTAG/+ Mice Open Access

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Juan Manuel Chao de la Barca; Gilles Simard; Emmanuelle Sarzi; Tanguy Chaumette; Guillaume Rousseau; Stéphanie Chupin; Cédric Gadras; Lydie Tessier; Marc Ferré; Arnaud Chevrollier; Valérie Desquiret-Dumas; Naïg Gueguen; Stéphanie Leruez; Christophe Verny; Dan Miléa; Dominique Bonneau; Patrizia Amati-Bonneau; Vincent Procaccio; Christian Hamel; Guy Lenaers; Pascal Reynier; Delphine Prunier-Mirebeau

Tags: mice, optic atrophy, autosomal dominant, optic nerve, metabolites

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 812-820. doi:https://doi.org/10.1167/iovs.16-21116

Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea Open Access

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Edward J. Wladis; Supraja Swamy; Alyssa Herrmann; Jinhong Yang; J. Andrew Carlson; Alejandro P. Adam

Tags: mitogen-activated protein kinases, ocular rosacea, proteins, rosacea, signal transduction

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 843-848. doi:https://doi.org/10.1167/iovs.16-20275

Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium Open Access

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Junli Zhao; Yi Liao; Jingmeng Chen; Xinran Dong; Zhan Gao; Houjian Zhang; Xiaodan Wu; Zuguo Liu; Yalin Wu

Tags: dimers, lipofuscin, tissue degeneration, retinal pigment cell, apoptosis

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1063-1075. doi:https://doi.org/10.1167/iovs.16-20734

Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid–Independent Pathway Open Access

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Antionette L. Williams; Jessica Eason; Bahaar Chawla; Brenda L. Bohnsack

Tags: embryo, fissure, rna, messenger, tretinoin, zebrafish

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1084-1097. doi:https://doi.org/10.1167/iovs.16-20235

Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization Open Access

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Tomomi Masuda; Masamitsu Shimazawa; Yuhei Hashimoto; Atsushi Kojima; Shinsuke Nakamura; Shinsuke Suemori; Kiyofumi Mochizuki; Hideaki Kawakami; Kazuhide Kawase; Hideaki Hara

Tags: angiogenesis, apolipoprotein e, apolipoprotein e2, neovascularization, pathologic, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1208-1217. doi:https://doi.org/10.1167/iovs.16-20539

Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation Open Access

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Xionggao Huang; Guohong Zhou; Wenyi Wu; Gaoen Ma; Patricia A. D'Amore; Shizuo Mukai; Hetian Lei

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1228-1236. doi:https://doi.org/10.1167/iovs.16-20537

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD Open Access

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Manas R. Biswal; Pingyang Han; Ping Zhu; Zhaoyang Wang; Hong Li; Cristhian J. Ildefonso; Alfred S. Lewin

Tags: antioxidants, disease vectors, electroretinography, eye, gene therapy

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1237-1245. doi:https://doi.org/10.1167/iovs.16-21272

Clinical and Epidemiologic Research

The Prognostic Value of AJCC Staging in Uveal Melanoma Is Enhanced by Adding Chromosome 3 and 8q Status Open Access

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Mehmet Dogrusöz; Mette Bagger; Sjoerd G. van Duinen; Wilma G. Kroes; Claudia A. L. Ruivenkamp; Stefan Böhringer; Klaus Kaae Andersen; Gregorius P. M. Luyten; Jens F. Kiilgaard; Martine J. Jager

Tags: chromosomes, chromosomes, human, pair 3, incidence, neoplasm metastasis, neoplasms

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 833-842. doi:https://doi.org/10.1167/iovs.16-20212

Use of a Supplemental Oxygen Protocol to Suppress Progression of Retinopathy of Prematurity Open Access

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Tarah T. Colaizy; Susannah Longmuir; Kevin Gertsch; Michael David Abràmoff; Jonathan M. Klein

Tags: oxygen, oxygen therapy, retinopathy of prematurity, infant, cohort studies

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 887-891. doi:https://doi.org/10.1167/iovs.16-20822

Measuring Trachomatous Inflammation-Intense (TI) When Prevalence Is Low Provides Data on Infection With Chlamydia trachomatis Open Access

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Andrea I. Zambrano; Beatriz E. Muñoz; Harran Mkocha; Laura Dize; Charlotte A. Gaydos; Thomas Quinn; Sheila K. West

Tags: chlamydia trachomatis, infections, inflammation, prevalence, trachoma

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 997-1000. doi:https://doi.org/10.1167/iovs.16-20421

Loss of Temporal Peripapillary Retinal Nerve Fibers in Prediabetes or Type 2 Diabetes Without Diabetic Retinopathy: The Maastricht Study Open Access

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Eline E. B. De Clerck; Jan S. A. G. Schouten; Tos T. J. M. Berendschot; Henny J. M. Beckers; Nicolaas C. Schaper; Miranda T. Schram; Coen D. A. Stehouwer; Carroll A. B. Webers

Tags: diabetes mellitus, type 2, diabetic retinopathy, myotonic dystrophy type 2, prediabetes, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1017-1027. doi:https://doi.org/10.1167/iovs.16-19638

Time Outdoors at Specific Ages During Early Childhood and the Risk of Incident Myopia Open Access

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Rupal L. Shah; Yu Huang; Jeremy A. Guggenheim; Cathy Williams

Tags: child, myopia

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1158-1166. doi:https://doi.org/10.1167/iovs.16-20894

Cornea

Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation Open Access

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Alfonso L. Sabater; Enrique J. Andreu; María García-Guzmán; Tania López; Gloria Abizanda; Victor L. Perez; Javier Moreno-Montañés; Felipe Prósper

Tags: 1-phosphatidylinositol 3-kinase, cornea, endothelial cells, oryctolagus cuniculus, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 745-754. doi:https://doi.org/10.1167/iovs.16-20817

Meibomian Gland Physiology in Pre- and Postmenopausal Women Open Access

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Tomo Suzuki; Yasuaki Minami; Aoi Komuro; Norihiko Yokoi; Shigeru Kinoshita

Tags: meibomian gland, physiology, postmenopause, premenopause, gonadal steroid hormones

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 763-771. doi:https://doi.org/10.1167/iovs.16-20811

Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress Open Access

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Eun Chul Kim; Tetsuya Toyono; Cynthia A. Berlinicke; Donald J. Zack; Ula Jurkunas; Tomohiko Usui; Albert S. Jun

Tags: cornea, endothelial cells, hydrogen peroxide, mefenamic acid, oxidative stress

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 892-900. doi:https://doi.org/10.1167/iovs.16-20147

Objective Quantification of Changes in Corneal Clouding Over Time in Patients With Mucopolysaccharidosis Open Access

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Ahmed Javed; Tariq Aslam; Simon A. Jones; Jane Ashworth

Tags: corneal opacity, mucopolysaccharidoses, hematopoietic stem cell transplantation, biological markers

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 954-958. doi:https://doi.org/10.1167/iovs.16-20647

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis Open Access

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Galina Dvoriantchikova; Wensi Tao; Steve Pappas; Gabriel Gaidosh; David T. Tse; Dmitry Ivanov; Daniel Pelaez

Tags: lacrimal gland, morphogenesis, signal transduction, molecular profiling

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1098-1109. doi:https://doi.org/10.1167/iovs.16-20315

Loss of Tryptophan Fluorescence Correlates With Mechanical Stiffness Following Photo-Crosslinking Treatment of Rabbit Cornea Open Access

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Maura Williams; William Lewis; Walfre Franco

Tags: cornea, fluorescence, oryctolagus cuniculus, riboflavin, tryptophan

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1110-1115. doi:https://doi.org/10.1167/iovs.16-20750

PDGFRα Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts Open Access

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Sriniwas Sriram; Jennifer A. Tran; Xiaoqing Guo; Audrey E. K. Hutcheon; Hetian Lei; Andrius Kazlauskas; James D. Zieske

Tags: cell lines, cornea, fibroblasts, fluorescent antibody technique, transforming growth factor beta3

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1179-1186. doi:https://doi.org/10.1167/iovs.16-20016

Anti-Inflammatory and Antioxidative Effects of Camellia japonica on Human Corneal Epithelial Cells and Experimental Dry Eye: In Vivo and In Vitro Study Open Access

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Hyo Seok Lee; Joo-Hee Choi; Lian Cui; Ying Li; Jee Myung Yang; Je-Jung Yun; Ji Eun Jung; Won Choi; Kyung Chul Yoon

Tags: anti-inflammatory agents, camellia, cornea, corneal epithelial cells, dry eye syndromes

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1196-1207. doi:https://doi.org/10.1167/iovs.16-20634

A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr Open Access

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Ángel Ortillés; Pilar Goñi; Encarnación Rubio; Marta Sierra; Ekaterina Gámez; María T. Fernández; María Benito; José Á. Cristóbal; Begoña Calvo

Tags: acanthamoeba keratitis, contact lenses, contact lenses, hydrophilic, corneal epithelium, debridement

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1218-1227. doi:https://doi.org/10.1167/iovs.16-21100

Clinic-Based Study on Meibomian Gland Dysfunction in Japan Open Access

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Shiro Amano; Kenji Inoue

Tags: meibomian gland, pathophysiology, prevalence, dry eye syndromes, questionnaires

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1283-1287. doi:https://doi.org/10.1167/iovs.16-21374

T Cell–Derived Granulocyte-Macrophage Colony-Stimulating Factor Contributes to Dry Eye Disease Pathogenesis by Promoting CD11b+ Myeloid Cell Maturation and Migration Open Access

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Thomas H. Dohlman; Julia Ding; Reza Dana; Sunil K. Chauhan

Tags: granulocyte-macrophage colony-stimulating factor, recombinant granulocyte-macrophage colony-stimulating factors, dry eye syndromes, t-lymphocytes, pathogenesis

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1330-1336. doi:https://doi.org/10.1167/iovs.16-20789

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Reduced Acuity and Stereo Acuity on Saccades and Reaching Movements in Adults With Amblyopia and Strabismus Open Access

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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Linda Colpa; Manokaraananthan Chandrakumar; Agnes M. F. Wong

Tags: amblyopia, strabismus, saccades, adult, eye

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 914-921. doi:https://doi.org/10.1167/iovs.16-20727

Evaluation of Progressive Visual Dysfunction and Retinal Degeneration in Patients With Parkinson's Disease Open Access

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Maria Satue; Maria J. Rodrigo; Javier Obis; Elisa Vilades; Hector Gracia; Sofia Otin; Maria I. Fuertes; Raquel Alarcia; Jose A. Crespo; Vicente Polo; Jose M. Larrosa; Luis E. Pablo; Elena Garcia-Martin

Tags: parkinson disease, retinal degeneration, vision disorders, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1151-1157. doi:https://doi.org/10.1167/iovs.16-20460

Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3-Linked Achromatopsia Open Access

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Jolanta Lisowska; Lukasz Lisowski; Carina Kelbsch; Fumiatsu Maeda; Paul Richter; Susanne Kohl; Ditta Zobor; Torsten Strasser; Krunoslav Stingl; Eberhart Zrenner; Tobias Peters; Helmut Wilhelm; M. Dominik Fischer; Barbara Wilhelm; for the RD-CURE Consortium

Tags: achromatopsia, gene therapy, pupil reaction, dark adaptation, retinal cone

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1274-1282. doi:https://doi.org/10.1167/iovs.16-20505

Genetics

A Japanese Family With Autosomal Dominant Oculocutaneous Albinism Type 4 Open Access

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Ryoko Oki; Kisaburo Yamada; Satoko Nakano; Kenichi Kimoto; Ken Yamamoto; Hiroyuki Kondo; Toshiaki Kubota

Tags: albinism, oculocutaneous, family, foveal hypoplasia, japanese, oculocutaneous albinism type 4

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1008-1016. doi:https://doi.org/10.1167/iovs.16-20612

The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families Open Access

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Vafa Keser; Ayesha Khan; Sorath Siddiqui; Irma Lopez; Huanan Ren; Raheel Qamar; Javad Nadaf; Jacek Majewski; Rui Chen; Robert K. Koenekoop

Tags: family, genes, genetics, mutation, phenotype

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1028-1036. doi:https://doi.org/10.1167/iovs.16-20281

Analysis of the PRPF31 Gene in Spanish Autosomal Dominant Retinitis Pigmentosa Patients: A Novel Genomic Rearrangement Open Access

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Inmaculada Martin-Merida; Rocio Sanchez-Alcudia; Patricia Fernandez-San Jose; Fiona Blanco-Kelly; Raquel Perez-Carro; Luciana Rodriguez-Jacy da Silva; Berta Almoguera; Blanca Garcia-Sandoval; Maria Isabel Lopez-Molina; Almudena Avila-Fernandez; Miguel Carballo; Marta Corton; Carmen Ayuso

Tags: family, gene rearrangement, genes, mutation, retinitis pigmentosa

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1045-1053. doi:https://doi.org/10.1167/iovs.16-20515

Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations Open Access

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Li Ma; Marten E. Brelen; Motokazu Tsujikawa; Haoyu Chen; Wai Kit Chu; Timothy Y. Y. Lai; Danny S. C. Ng; Kaori Sayanagi; Chicako Hara; Noriyasu Hashida; Vesta C. K. Chan; Pancy O. S. Tam; Alvin L. Young; Weiqi Chen; Kohji Nishida; Chi Pui Pang; Li Jia Chen

Tags: chinese (other dialects), chinese people, cohort studies, exudative age-related macular degeneration, genes

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1076-1083. doi:https://doi.org/10.1167/iovs.16-20575

Mitochondrial Haplogroups Affect Severity But Not Prevalence of Diabetic Retinopathy Open Access

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Jana A. Bregman; David J. Herren; Christopher B. Estopinal; Isaac M. Chocron; Paula A. Harlow; Cassandra Warden; Milam A. Brantley, Jr; David C. Samuels

Tags: diabetes mellitus, diabetic retinopathy, mitochondria, nonproliferative diabetic retinopathy, prevalence

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1346-1351. doi:https://doi.org/10.1167/iovs.16-20616

Glaucoma

Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera Open Access

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Cathy Nguyen; Dan Midgett; Elizabeth C. Kimball; Matthew R. Steinhart; Thao D. Nguyen; Mary E. Pease; Ericka N. Oglesby; Joan L. Jefferys; Harry A. Quigley

Tags: intraocular pressure, mice, optic disk, sclera, astrocytes

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 721-733. doi:https://doi.org/10.1167/iovs.16-20620

Diagnostic Power of Lamina Cribrosa Depth and Curvature in Glaucoma Open Access

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Seung Hyen Lee; Tae-Woo Kim; Eun Ji Lee; Michaël J. A. Girard; Jean Martial Mari

Tags: cribriform plate, eye, glaucoma, open-angle glaucoma

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 755-762. doi:https://doi.org/10.1167/iovs.16-20802

Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells Open Access

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Avani A. Mody; Robert J. Wordinger; Abbot F. Clark

Tags: proteins, rna, messenger

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 849-859. doi:https://doi.org/10.1167/iovs.16-20472

Reclaiming the Periphery: Automated Kinetic Perimetry for Measuring Peripheral Visual Fields in Patients With Glaucoma Open Access

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Vera M. Mönter; David P. Crabb; Paul H. Artes

Tags: glaucoma, kinetics, perimetry, visual fields

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 868-875. doi:https://doi.org/10.1167/iovs.16-19868

Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype Open Access

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Rui Wang; Philip Seifert; Tatjana C. Jakobs

Tags: astrocytes, glaucoma, injections, mice, microspheres

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 924-932. doi:https://doi.org/10.1167/iovs.16-20571

TGFβ2 Induces the Formation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells Through the Smad and Non-Smad Dependent Pathways Open Access

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Michela Montecchi-Palmer; Jaclyn Y. Bermudez; Hannah C. Webber; Gaurang C. Patel; Abbot F. Clark; Weiming Mao

Tags: actins, trabecular meshwork, stress fibers

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1288-1295. doi:https://doi.org/10.1167/iovs.16-19672

Immunology and Microbiology

Microglia Activation and Recruitment of Circulating Macrophages During Ischemic Experimental Branch Retinal Vein Occlusion Open Access

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Andreas Ebneter; Despina Kokona; Nadia Schneider; Martin S. Zinkernagel

Tags: hypoxia, ischemia, lasers, macrophages, mice

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 944-953. doi:https://doi.org/10.1167/iovs.16-20474

Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease Open Access

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Cristhian A. Urzua; Julia Guerrero; Hector Gatica; Victor Velasquez; Annelise Goecke

Tags: biological markers, glucocorticoid receptors, predictor variable, protein isoforms, uveomeningoencephalitic syndrome

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 974-980. doi:https://doi.org/10.1167/iovs.16-20783

Retinal Pigment Epithelial Cells Suppress Phagolysosome Activation in Macrophages Open Access

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Eric Wang; Yoona Choe; Tat Fong Ng; Andrew W. Taylor

Tags: interleukin-6, macrophages, neuropeptide y, retinal pigment cell, mice

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1266-1273. doi:https://doi.org/10.1167/iovs.16-21082

Lens

Bone Morphogenetic Protein-7 Suppresses TGFβ2-Induced Epithelial-Mesenchymal Transition in the Lens: Implications for Cataract Prevention Open Access

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Daisy Y. Shu; Magdalena C. Wojciechowski; Frank J. Lovicu

Tags: cataract, epithelial to mesenchymal transition, epithelium, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 781-796. doi:https://doi.org/10.1167/iovs.16-20611

Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells Open Access

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Malgorzata Goralska; Lloyd N. Fleisher; M. Christine McGahan

Tags: ferritin, iron, proteins, transferrin receptors, vitreous body

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1187-1195. doi:https://doi.org/10.1167/iovs.16-20610

Multidisciplinary Ophthalmic Imaging

Collagen Architecture of the Posterior Pole: High-Resolution Wide Field of View Visualization and Analysis Using Polarized Light Microscopy Open Access

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Ning-Jiun Jan; Kira Lathrop; Ian A. Sigal

Tags: collagen, microscopy, polarization, sclera

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 735-744. doi:https://doi.org/10.1167/iovs.16-20772

Positron Emission Tomography for the Development and Characterization of Corneal Permanence of Ophthalmic Pharmaceutical Formulations Open Access

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Anxo Fernández-Ferreiro; Jesús Silva-Rodríguez; Francisco Javier Otero-Espinar; Miguel González-Barcia; María Jesús Lamas; Alvaro Ruibal; Andrea Luaces-Rodriguez; Alba Vieites-Prado; Tomas Sobrino; Michel Herranz; Lara García-Varela; José Blanco-Mendez; María Gil-Martínez; María Pardo; Alexis Moscoso; Santiago Medín-Aguerre; Juan Pardo-Montero; Pablo Aguiar

Tags: cornea, dosage forms, eye, hydrogel, positron-emission tomography

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 772-780. doi:https://doi.org/10.1167/iovs.16-20766

Physiology and Pharmacology

Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT Open Access

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Gerold C. Aschinger; Leopold Schmetterer; Klemens Fondi; Valentin Aranha Dos Santos; Gerald Seidel; Gerhard Garhöfer; René M. Werkmeister

Tags: luminance, optical coherence tomography, photopsia, vascular flow, diameter

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1167-1178. doi:https://doi.org/10.1167/iovs.16-20598

Retina

Functional and Anatomical Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab Open Access

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Audrey Giocanti-Aurégan; Linda Hrarat; Lise M. Qu; Valérie Sarda; Marouane Boubaya; Vincent Levy; Gilles Chaine; Franck Fajnkuchen

Tags: diabetic macular edema, exudative retinal detachment, ranibizumab

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 797-800. doi:https://doi.org/10.1167/iovs.16-20855

Parapapillary Diffuse Choroidal Atrophy in Children Is Associated With Extreme Thinning of Parapapillary Choroid Open Access

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Tae Yokoi; Dan Zhu; Hong Sheng Bi; Jost B. Jonas; Rahul A. Jonas; Natsuko Nagaoka; Muka Moriyama; Takeshi Yoshida; Kyoko Ohno-Matsui

Tags: child, choroid, choroidal atrophy, refractive errors

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 901-906. doi:https://doi.org/10.1167/iovs.16-20652

Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? Open Access

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Chee Wai Wong; Val Phua; Shu Yen Lee; Tien Yin Wong; Chui Ming Gemmy Cheung

Tags: eye, myopic macular degeneration, sclera

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 907-913. doi:https://doi.org/10.1167/iovs.16-20742

Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice Open Access

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Wenzhong Liu; Shoujian Wang; Brian Soetikno; Ji Yi; Kevin Zhang; Siyu Chen; Robert A. Linsenmeier; Christine M. Sorenson; Nader Sheibani; Hao F. Zhang

Tags: diabetes mellitus, metabolism, mice, oxygen, somalia

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 981-989. doi:https://doi.org/10.1167/iovs.16-20600

Differential Disease Progression in Atrophic Age-Related Macular Degeneration and Late-Onset Stargardt Disease Open Access

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Moritz Lindner; Stanley Lambertus; Matthias M. Mauschitz; Nathalie M. Bax; Eveline Kersten; Anna Lüning; Jennifer Nadal; Steffen Schmitz-Valckenberg; Matthias Schmid; Frank G. Holz; Carel B. Hoyng; Monika Fleckenstein; for the Foveal sparing Atrophy Study Team (FAST)

Tags: age-related macular degeneration, nonexudative, atrophy, disease progression, stargardt's disease, eye

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1001-1007. doi:https://doi.org/10.1167/iovs.16-20980

Wide-Field En Face Swept-Source Optical Coherence Tomography Features of Extrafoveal Retinoschisis in Highly Myopic Eyes Open Access

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Wei Xiao; Zhuoting Zhu; Capucine Odouard; Ou Xiao; Xinxing Guo; Mingguang He

Tags: eye, face, optical coherence tomography, retinoschisis

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1037-1044. doi:https://doi.org/10.1167/iovs.16-20607

Classification of Exudative Age-Related Macular Degeneration With Pachyvessels on En Face Swept-Source Optical Coherence Tomography Open Access

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Danny Siu-Chun Ng; Malini Bakthavatsalam; Frank Hiu-Ping Lai; Carol Yim-Lui Cheung; Gemmy Chu-Ming Cheung; Fang Yao Tang; Chi Wai Tsang; Timothy Yuk-Yau Lai; Tien Yin Wong; Mårten Erik Brelén

Tags: cortical blindness, exudative age-related macular degeneration, eye, face, optical coherence tomography

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1054-1062. doi:https://doi.org/10.1167/iovs.16-20519

Blood Vessel Basement Membrane Alterations in Human Retinal Microaneurysms During Aging Open Access

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Mariana López-Luppo; Victor Nacher; David Ramos; Joana Catita; Marc Navarro; Ana Carretero; Alfonso Rodriguez-Baeza; Luísa Mendes-Jorge; Jesús Ruberte

Tags: microaneurysm, proteins, retinal microaneurysm, basement membrane, aging

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1116-1131. doi:https://doi.org/10.1167/iovs.16-19998

Changes in Retinal Microcirculation After Intravitreal Ranibizumab Injection in Eyes With Macular Edema Secondary to Branch Retinal Vein Occlusion Open Access

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Marie Fukami; Takeshi Iwase; Kentaro Yamamoto; Hiroki Kaneko; Shunsuke Yasuda; Hiroko Terasaki

Tags: edema, eye, injections, microcirculation, ranibizumab

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1246-1255. doi:https://doi.org/10.1167/iovs.16-21115

Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs Open Access

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Li Guoping; Ye Xiang; Wu Jianfeng; Guo Dadong; Huang Jie; Jiang Wenjun; Guo Junguo; Bi Hongsheng

Tags: caviidae, eye, eye development, gamma-aminobutyric acid, glutamate

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1256-1265. doi:https://doi.org/10.1167/iovs.16-21130

Senescent Changes and Topography of the Dark-Adapted Multifocal Electroretinogram Open Access

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Athanasios Panorgias; Megan Tillman; Erich E. Sutter; Ala Moshiri; Christina Gerth-Kahlert; John S. Werner

Tags: aging, electroretinography, retina, rod photoreceptors, photopsia

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1323-1329. doi:https://doi.org/10.1167/iovs.16-20953

Three-Dimensional Analysis of Morphologic Changes and Visual Outcomes in Neovascular Age-Related Macular Degeneration Open Access

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Hyungwoo Lee; Aerin Jo; Hyung Chan Kim

Tags: embryonic lethal mutation, exudative age-related macular degeneration, photoreceptors, regression analysis, visual acuity

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1337-1345. doi:https://doi.org/10.1167/iovs.16-20637

Retinal Cell Biology

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model Open Access

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Matthew G. Pilgrim; Imre Lengyel; Antonio Lanzirotti; Matt Newville; Sarah Fearn; Eszter Emri; Jonathan C. Knowles; Jeffrey D. Messinger; Russell W. Read; Clyde Guidry; Christine A. Curcio

Tags: cell culture techniques, diffuse idiopathic skeletal hyperostosis, drusen, durapatite, hydroxyapatites

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 708-719. doi:https://doi.org/10.1167/iovs.16-21060

Toll-Like Receptor 3 Activation Initiates Photoreceptor Cell Death In Vivo and In Vitro Open Access

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Mei-Ling Gao; Kun-Chao Wu; Wen-Li Deng; Xin-Lan Lei; Lue Xiang; Gao-Hui Zhou; Chun-Yun Feng; Xue-Wen Cheng; Chang-Jun Zhang; Feng Gu; Rong-Han Wu; Zi-Bing Jin

Tags: mice, photoreceptors, poly i-c, retina, toll-like receptor 3

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 801-811. doi:https://doi.org/10.1167/iovs.16-20692

Adenosine Deaminase-2–Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p Open Access

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Yara A. Samra; Heba M. Saleh; Khaled A. Hussein; Nehal M. Elsherbiny; Ahmed S. Ibrahim; Khaled Elmasry; Sadanand Fulzele; Mamdouh M. El-Shishtawy; Laila A. Eissa; Mohamed Al-Shabrawey; Gregory I. Liou

Tags: adenosine, albumins, cecr1 gene, diabetic retinopathy, endothelial cells

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 933-943. doi:https://doi.org/10.1167/iovs.16-19782

Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina Open Access

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Ko Uoon Park; Grace Randazzo; Kenneth L. Jones; Joseph A. Brzezinski, IV

Tags: genes, interneurons, mice, retina, retinal bipolar cells

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1137-1150. doi:https://doi.org/10.1167/iovs.16-19767

The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity Open Access

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Sean F. Hackett; Christopher Seidel; Sheena Abraham; Rishi Chadha; Seth D. Fortmann; Peter A. Campochiaro; John P. Cooke

Tags: cholinergic agents, ischemia, mecamylamine, mice, retinal neovascularization

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1296-1303. doi:https://doi.org/10.1167/iovs.16-20670

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy Open Access

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Sandra Petrus-Reurer; Hammurabi Bartuma; Monica Aronsson; Sofie Westman; Fredrik Lanner; Helder André; Anders Kvanta

Tags: atrophy, blister, embryo, eye, injections

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1314-1322. doi:https://doi.org/10.1167/iovs.16-20738

Visual Neuroscience

The Clinical Phenotype of CNGA3-Related Achromatopsia: Pretreatment Characterization in Preparation of a Gene Replacement Therapy Trial Open Access

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Ditta Zobor; Annette Werner; Franco Stanzial; Francesco Benedicenti; Günther Rudolph; Ulrich Kellner; Christian Hamel; Sten Andréasson; Gergely Zobor; Torsten Strasser; Bernd Wissinger; Susanne Kohl; Eberhart Zrenner; for the RD-CURE Consortium

Tags: achromatopsia, genes, vif, phenotype, psychophysics, retinal cone

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 821-832. doi:https://doi.org/10.1167/iovs.16-20427

Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene Open Access

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Geoffrey K. Aguirre; Omar H. Butt; Ritobrato Datta; Alejandro J. Roman; Alexander Sumaroka; Sharon B. Schwartz; Artur V. Cideciyan; Samuel G. Jacobson

Tags: blindness, functional magnetic resonance imaging, genes, mutation, photoreceptors

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 959-973. doi:https://doi.org/10.1167/iovs.16-20413

Intrinsically Photosensitive Retinal Ganglion Cell Function, Sleep Efficiency and Depression in Advanced Age-Related Macular Degeneration Open Access

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Michelle L. Maynard; Andrew J. Zele; Anthony S. Kwan; Beatrix Feigl

Tags: age-related macular degeneration, depressive disorders, retinal ganglion cells, sleep

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 990-996. doi:https://doi.org/10.1167/iovs.16-20659

Loss of Binocular Vision in Monocularly Blind Patients Causes Selective Degeneration of the Superior Lateral Occipital Cortices Open Access

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Doety Prins; Nomdo M. Jansonius; Frans W. Cornelissen

Tags: blindness, tissue degeneration, vision, binocular, visual cortex, visual pathways

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1304-1313. doi:https://doi.org/10.1167/iovs.16-20404

Visual Psychophysics and Physiological Optics

The Effect of Aging and Attention on Visual Crowding and Surround Suppression of Perceived Contrast Threshold Open Access

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Menaka S. Malavita; Trichur R. Vidyasagar; Allison M. McKendrick

Tags: aging, attention, crowding, perception

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 860-867. doi:https://doi.org/10.1167/iovs.16-20632

New Developments in Vision Research

Protection of Glial Müller Cells by Dexamethasone in a Mouse Model of Surgically Induced Blood–Retinal Barrier Breakdown Open Access

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Lourdes Siqueiros-Marquez; Romain Bénard; Ophélie Vacca; Hugo Charles-Messance; Rodrigo Bolaños-Jimenez; Xavier Guilloneau; Florian Sennlaub; Cecilia Montañez; José Alain Sahel; Alvaro Rendon; Ramin Tadayoni; Audrey Giocanti-Aurégan

Tags: dexamethasone, mice, surgical procedures, operative, lens (device), surgery specialty

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 876-886. doi:https://doi.org/10.1167/iovs.16-20617

Letters to the Editor

“Hypodense Holes” and the Ocular Glymphatic System: Author Response: “Black Holes” and the Ocular Glymphatic System Open Access

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Peter Wostyn; Veva De Groot; Debby Van Dam; Kurt Audenaert; Peter Paul De Deyn; Hanspeter Esriel Killer

Tags: body fluid, brain, glaucoma, magnetic resonance imaging, retina

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1132-1133. doi:https://doi.org/10.1167/iovs.16-21143

The Ocular Glymphatic System and Idiopathic Intracranial Hypertension: Author Response to “Hypodense Holes and the Ocular Glymphatic System” Open Access

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Alastair K. Denniston; Pearse A. Keane; Anuriti Aojula; Alex J. Sinclair; Susan P. Mollan

Tags: pseudotumor cerebri

Investigative Ophthalmology & Visual Science February 2017, Vol.58, 1134-1136. doi:https://doi.org/10.1167/iovs.17-21479

Erratum

Erratum Open Access

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Investigative Ophthalmology & Visual Science February 2017, Vol.58, 922. doi:https://doi.org/10.1167/iovs.13-11814a

Erratum Open Access

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Investigative Ophthalmology & Visual Science February 2017, Vol.58, 923. doi:https://doi.org/10.1167/iovs.16-19687a

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