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Research Highlight

Cross Talk Between TGF-β2 and TLR-4 Open Access
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Paul A. Knepper
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1824. doi:10.1167/iovs.17-21782

Anatomy and Pathology/Oncology

Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits Open Access
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Vladimir Bantseev; Paul E. Miller; Ellison Bentley; Chris Schuetz; Tim M. Streit; Brian J. Christian; Cindy Farman; Helen Booler; Evan A. Thackaberry
Tags: dutch, endotoxins, eye, intravitreal injections, no-observed-effect level
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1545-1552. doi:10.1167/iovs.16-21356
A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model Open Access
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Mariana B. Garcia; Amit K. Jha; Kevin E. Healy; Christine F. Wildsoet
Tags: eye, guinea, hydrogel, implants, myopia
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1875-1886. doi:10.1167/iovs.16-20694

Clinical and Epidemiologic Research

Visualization of Dietary Patterns and Their Associations With Age-Related Macular Degeneration Open Access
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Chung-Jung Chiu; Min-Lee Chang; Tricia Li; Gary Gensler; Allen Taylor
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1404-1410. doi:10.1167/iovs.16-20454
Protective Role of Orthokeratology in Reducing Risk of Rapid Axial Elongation: A Reanalysis of Data From the ROMIO and TO-SEE Studies Open Access
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Pauline Cho; Sin-Wan Cheung
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1411-1416. doi:10.1167/iovs.16-20594
The Response AC/A Ratio Before and After the Onset of Myopia Open Access
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Donald O. Mutti; G. Lynn Mitchell; Lisa A. Jones-Jordan; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; J. Daniel Twelker; Karla Zadnik; for the CLEERE Study Group
Tags: child, myopia, refractive errors
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1594-1602. doi:10.1167/iovs.16-19093
A New Method of Magnification Correction for Accurately Measuring Retinal Vessel Calibers From Fundus Photographs Open Access
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Aiko Iwase; Akihiko Sekine; Jun Suehiro; Kenji Tanaka; Yumiko Kawasaki; Ryo Kawasaki; Michael J. Sinai; Makoto Araie
Tags: eye, fundus photography, magnification, retinal vascular caliber
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1858-1864. doi:10.1167/iovs.16-21202
Sex Disparity in Survival of Patients With Uveal Melanoma: Better Survival Rates in Women Than in Men in South Korea Open Access
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San Jun Park; Chang-Mo Oh; Bora Yeon; Hyunsoon Cho; Kyu Hyung Park
Tags: gender disparities, intraocular melanoma, south korea, survival rate
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1909-1915. doi:10.1167/iovs.16-20077

Cornea

Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development Open Access
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Seungwoon Seo; Lisheng Chen; Wenzhong Liu; Demin Zhao; Kathryn M. Schultz; Amy Sasman; Ting Liu; Hao F. Zhang; Philip J. Gage; Tsutomu Kume
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1368-1377. doi:10.1167/iovs.16-21217
Silk-Derived Protein Enhances Corneal Epithelial Migration, Adhesion, and Proliferation Open Access
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Waleed Abdel-Naby; Brigette Cole; Aihong Liu; Jingbo Liu; Pengxia Wan; Victor H. Guaiquil; Ryan Schreiner; David Infanger; Brian D. Lawrence; Mark I. Rosenblatt
Tags: adhesions, cornea, epithelium, fibroins, proteins
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1425-1433. doi:10.1167/iovs.16-19957
Subconjunctival Bevacizumab Injection Impairs Corneal Innervations and Epithelial Wound Healing in Mice Open Access
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Muchen Dong; Guohu Di; Xiaoping Zhang; Qingjun Zhou; Weiyun Shi
Tags: bevacizumab, cornea, epithelium, injections, mice
Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1469-1477. doi:10.1167/iovs.16-20926
Extracellular Collagen Promotes Interleukin-1β–Induced Urokinase-Type Plasminogen Activator Production by Human Corneal Fibroblasts Open Access