Volume 58 Issue 3 | IOVS

Cross Talk Between TGF-β2 and TLR-4 Open Access

Paul A. Knepper

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1824. doi:10.1167/iovs.17-21782

Determination of a No-Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Dutch Belted Rabbits Open Access

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Vladimir Bantseev; Paul E. Miller; Ellison Bentley; Chris Schuetz; Tim M. Streit; Brian J. Christian; Cindy Farman; Helen Booler; Evan A. Thackaberry

Tags: dutch, endotoxins, eye, intravitreal injections, no-observed-effect level

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1545-1552. doi:10.1167/iovs.16-21356

A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model Open Access

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Mariana B. Garcia; Amit K. Jha; Kevin E. Healy; Christine F. Wildsoet

Tags: eye, guinea, hydrogel, implants, myopia

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1875-1886. doi:10.1167/iovs.16-20694

Clinical and Epidemiologic Research

Visualization of Dietary Patterns and Their Associations With Age-Related Macular Degeneration Open Access

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Chung-Jung Chiu; Min-Lee Chang; Tricia Li; Gary Gensler; Allen Taylor

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1404-1410. doi:10.1167/iovs.16-20454

Protective Role of Orthokeratology in Reducing Risk of Rapid Axial Elongation: A Reanalysis of Data From the ROMIO and TO-SEE Studies Open Access

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Pauline Cho; Sin-Wan Cheung

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1411-1416. doi:10.1167/iovs.16-20594

The Response AC/A Ratio Before and After the Onset of Myopia Open Access

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Donald O. Mutti; G. Lynn Mitchell; Lisa A. Jones-Jordan; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; J. Daniel Twelker; Karla Zadnik; for the CLEERE Study Group

Tags: child, myopia, refractive errors

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1594-1602. doi:10.1167/iovs.16-19093

A New Method of Magnification Correction for Accurately Measuring Retinal Vessel Calibers From Fundus Photographs Open Access

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Aiko Iwase; Akihiko Sekine; Jun Suehiro; Kenji Tanaka; Yumiko Kawasaki; Ryo Kawasaki; Michael J. Sinai; Makoto Araie

Tags: eye, fundus photography, magnification, retinal vascular caliber

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1858-1864. doi:10.1167/iovs.16-21202

Sex Disparity in Survival of Patients With Uveal Melanoma: Better Survival Rates in Women Than in Men in South Korea Open Access

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San Jun Park; Chang-Mo Oh; Bora Yeon; Hyunsoon Cho; Kyu Hyung Park

Tags: gender disparities, intraocular melanoma, south korea, survival rate

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1909-1915. doi:10.1167/iovs.16-20077

Cornea

Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development Open Access

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Seungwoon Seo; Lisheng Chen; Wenzhong Liu; Demin Zhao; Kathryn M. Schultz; Amy Sasman; Ting Liu; Hao F. Zhang; Philip J. Gage; Tsutomu Kume

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1368-1377. doi:10.1167/iovs.16-21217

Silk-Derived Protein Enhances Corneal Epithelial Migration, Adhesion, and Proliferation Open Access

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Waleed Abdel-Naby; Brigette Cole; Aihong Liu; Jingbo Liu; Pengxia Wan; Victor H. Guaiquil; Ryan Schreiner; David Infanger; Brian D. Lawrence; Mark I. Rosenblatt

Tags: adhesions, cornea, epithelium, fibroins, proteins

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1425-1433. doi:10.1167/iovs.16-19957

Subconjunctival Bevacizumab Injection Impairs Corneal Innervations and Epithelial Wound Healing in Mice Open Access

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Muchen Dong; Guohu Di; Xiaoping Zhang; Qingjun Zhou; Weiyun Shi

Tags: bevacizumab, cornea, epithelium, injection of therapeutic agent, mice

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1469-1477. doi:10.1167/iovs.16-20926

Extracellular Collagen Promotes Interleukin-1β–Induced Urokinase-Type Plasminogen Activator Production by Human Corneal Fibroblasts Open Access

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Koji Sugioka; Aya Kodama-Takahashi; Koji Yoshida; Keiichi Aomatsu; Kiyotaka Okada; Teruo Nishida; Yoshikazu Shimomura

Tags: collagen, cornea, fibroblasts, gel, urokinase

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1487-1498. doi:10.1167/iovs.16-20685

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model Open Access

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Sean Tighe; Hamid-Reza Moein; Lorraine Chua; Anny Cheng; Pedram Hamrah; Scheffer C. G. Tseng

Tags: amnion, cornea, corneal abrasions, cryopreservation, epithelialization

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1586-1593. doi:10.1167/iovs.16-20834

Biomechanical Changes After In Vivo Collagen Cross-Linking With Rose Bengal–Green Light and Riboflavin-UVA Open Access

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Nandor Bekesi; Patricia Gallego-Muñoz; Lucía Ibarés-Frías; Pablo Perez-Merino; M. Carmen Martinez-Garcia; Irene E. Kochevar; Susana Marcos

Tags: cornea, corneal collagen cross-linking, green light, riboflavin, rose bengal

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1612-1620. doi:10.1167/iovs.17-21475

The Corneal Epithelial Barrier and Its Developmental Role in Isolating Corneal Epithelial and Conjunctival Cells From One Another Open Access

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James K. Kubilus; Carolina Zapater i Morales; Thomas F. Linsenmayer

Tags: conjunctiva, cornea, diffusion, epithelium, eye

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1665-1672. doi:10.1167/iovs.16-20737

Therapeutic Efficacy of Nanocomplex of Poly(Ethylene Glycol) and Catechin for Dry Eye Disease in a Mouse Model Open Access

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Hyesook Lee; Whuisu Shim; Chae Eun Kim; So Yeon Choi; Haeshin Lee; Jaewook Yang

Tags: catechin, dry eye syndromes, ethylene glycol, mice, cornea

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1682-1691. doi:10.1167/iovs.16-20843

Modulation of Circadian Rhythms Affects Corneal Epithelium Renewal and Repair in Mice Open Access

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Yunxia Xue; Peng Liu; Hanqing Wang; Chengju Xiao; Cuipei Lin; Jun Liu; Dong Dong; Ting Fu; Yabing Yang; Zhaorui Wang; Hongwei Pan; Jiansu Chen; Yangqiu Li; Dongqing Cai; Zhijie Li

Tags: circadian rhythms, cornea, corneal epithelium, epithelium, mice

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1865-1874. doi:10.1167/iovs.16-21154

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Temporal Binding Window of the Sound-Induced Flash Illusion in Amblyopia Open Access

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Cindy Narinesingh; Herbert C. Goltz; Agnes M. F. Wong

Tags: amblyopia, illusions, eye

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1442-1448. doi:10.1167/iovs.16-21258

Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids in a Rat Model of Anterior Ischemic Optic Neuropathy Open Access

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Tassos Georgiou; Yao-Tseng Wen; Chung-Hsing Chang; Panagiotis Kolovos; Maria Kalogerou; Ekatherine Prokopiou; Anastasia Neokleous; Chin-Te Huang; Rong-Kung Tsai

Tags: anterior ischemic optic neuropathy, macrophage, neuroprotective effect, omega-3 fatty acids, painful bladder syndrome

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1603-1611. doi:10.1167/iovs.16-20979

Genetics

Contribution of Mutations in Known Mendelian Glaucoma Genes to Advanced Early-Onset Primary Open-Angle Glaucoma Open Access

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Tiger Zhou; Emmanuelle Souzeau; Owen M. Siggs; John Landers; Richard Mills; Ivan Goldberg; Paul R. Healey; Stuart Graham; Alex W. Hewitt; David A. Mackey; Anna Galanopoulos; Robert J. Casson; Jonathan B. Ruddle; Jonathan Ellis; Paul Leo; Matthew A. Brown; Stuart MacGregor; Shiwani Sharma; Kathryn P. Burdon; Jamie E. Craig

Tags: genes, glaucoma, open-angle glaucoma, mutation, cohort studies

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1537-1544. doi:10.1167/iovs.16-21049

Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration Open Access

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Perciliz L. Tan; Melanie E. Garrett; Jason R. Willer; Peter A. Campochiaro; Betsy Campochiaro; Donald J. Zack; Allison E. Ashley-Koch; Nicholas Katsanis

Tags: age-related macular degeneration, cultural formulation interview, cohort studies, alleles

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1570-1576. doi:10.1167/iovs.16-20867

Gene Augmentation Therapy for a Missense Substitution in the cGMP-Binding Domain of Ovine CNGA3 Gene Restores Vision in Day-Blind Sheep Open Access

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Elisha Gootwine; Mazen Abu-Siam; Alexey Obolensky; Alex Rosov; Hen Honig; Tali Nitzan; Andrey Shirak; Raaya Ezra-Elia; Esther Yamin; Eyal Banin; Edward Averbukh; William W. Hauswirth; Ron Ofri; Eyal Seroussi

Tags: blindness, cyclic gmp, genes, mutation, sheep

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1577-1584. doi:10.1167/iovs.16-20986

Novel 25 kb Deletion of MERTK Causes Retinitis Pigmentosa With Severe Progression Open Access

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Daniel R. Evans; Jane S. Green; Gordon J. Johnson; Jeremy Schwartzentruber; Jacek Majewski; Chandree L. Beaulieu; Wen Qin; Christian R. Marshall; Tara A. Paton; Nicole M. Roslin; Andrew D. Paterson; Somayyeh Fahiminiya; Justin French; Kym M. Boycott; Michael O. Woods; for the FORGE Canada Consortium

Tags: mertk gene, retinitis pigmentosa, family

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1736-1742. doi:10.1167/iovs.16-20864

Myopia and Late-Onset Progressive Cone Dystrophy Associate to LVAVA/MVAVA Exon 3 Interchange Haplotypes of Opsin Genes on Chromosome X Open Access

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Orsolya Orosz; István Rajta; Attila Vajas; Lili Takács; Adrienne Csutak; Mariann Fodor; Bence Kolozsvári; Miklós Resch; Katalin Sényi; Balázs Lesch; Viktória Szabó; András Berta; István Balogh; Gergely Losonczy

Tags: cone dystrophy, exons, genes, haplotypes, myopia

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1834-1842. doi:10.1167/iovs.16-21405

Glaucoma

Mechanism of Action of Selective Laser Trabeculoplasty and Predictors of Response Open Access

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Vikas Gulati; Shan Fan; Bret J. Gardner; Shane J. Havens; Marie T. Schaaf; Donna G. Neely; Carol B. Toris

Tags: eye, intraocular pressure, laser trabeculoplasty, pharmacokinetics, fluorophotometry

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1462-1468. doi:10.1167/iovs.16-20710

Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy Open Access

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Huimin Shi; Huiying Wang; Shuhao Fu; Kang Xu; Xiaoyan Zhang; Yiqin Xiao; Wen Ye

Tags: angiotensin ii, blister, cicatrix, losartan, trabeculectomy

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1478-1486. doi:10.1167/iovs.16-21163

Underlying Microstructure of Parapapillary Deep-Layer Capillary Dropout Identified by Optical Coherence Tomography Angiography Open Access

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Eun Ji Lee; Tae-Woo Kim; Seung Hyen Lee; Jung-Ah Kim

Tags: angiogram, blood capillaries, eye, optical coherence tomography, choroid

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1621-1627. doi:10.1167/iovs.17-21440

Alterations of the Foveal Avascular Zone Measured by Optical Coherence Tomography Angiography in Glaucoma Patients With Central Visual Field Defects Open Access

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Junki Kwon; Jaewan Choi; Joong Won Shin; Jiyun Lee; Michael S. Kook

Tags: angiogram, glaucoma, optical coherence tomography, scotoma, eye

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1637-1645. doi:10.1167/iovs.16-21079

Grooved Glaucoma Drainage Devices That Continuously Deliver Cyclosporine A Decrease Postsurgical Scar Formation in Rabbit Eyes Open Access

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Zhaoxing Dai; Xiaobo Yu; Jianguo Sun; Xinghuai Sun

Tags: anterior chamber of eye, blister, cicatrix, cyclosporine, diagnostic radiologic examination

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1692-1701. doi:10.1167/iovs.16-21065

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork Open Access

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Humberto Hernandez; Wanda E. Medina-Ortiz; Tomi Luan; Abbot F. Clark; Colleen M. McDowell

Tags: signal transduction, toll-like receptor 4, trabecular meshwork, transforming growth factors, mice

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1811-1823. doi:10.1167/iovs.16-21331

Impact of Rates of Change of Lamina Cribrosa and Optic Nerve Head Surface Depths on Visual Field Progression in Glaucoma Open Access

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Zhongheng Wu; Chen Lin; Michael Crowther; Heather Mak; Marco Yu; Christopher K.-S. Leung

Tags: cribriform plate, eye, glaucoma, optic disk, visual fields

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1825-1833. doi:10.1167/iovs.16-20509

Immunology and Microbiology

In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis Open Access

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Michal B. Gutowski; Leslie Wilson; Russell N. Van Gelder; Kathryn L. Pepple

Tags: animal model, bioluminescence, diagnostic imaging, inflammation, uveitis

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1521-1528. doi:10.1167/iovs.16-20824

Promoter Hypermethylation of GATA3, IL-4, and TGF-β Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese Open Access

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Yunyun Zhu; Hongsong Yu; Yiguo Qiu; Zi Ye; Wencheng Su; Jing Deng; Qingfeng Cao; Gangxiang Yuan; Aize Kijlstra; Peizeng Yang

Tags: gata3 gene, hypermethylation, interleukin-4, uveomeningoencephalitic syndrome, disease susceptibility

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1529-1536. doi:10.1167/iovs.16-21188

Establishment of Multiplex Solid-Phase Strip PCR Test for Detection of 24 Ocular Infectious Disease Pathogens Open Access

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Satoko Nakano; Sunao Sugita; Yasuhiro Tomaru; Ayumi Hono; Takako Nakamuro; Toshiaki Kubota; Hiroshi Takase; Manabu Mochizuki; Masayo Takahashi; Norio Shimizu

Tags: communicable diseases, pathogenic organism, polymerase chain reaction, solids, dna

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1553-1559. doi:10.1167/iovs.16-20556

Low Vision

A Comparison of Reach-to-Grasp and Transport-to-Place Performance in Participants With Age-Related Macular Degeneration and Glaucoma Open Access

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Shahina Pardhan; Amy Scarfe; Rupert Bourne; Matthew Timmis

Tags: age-related macular degeneration, biological transport, calcaneofibular ligament, glaucoma, velocity

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1560-1569. doi:10.1167/iovs.16-20273

Searching for Objects in Everyday Scenes: Measuring Performance in People With Dry Age-Related Macular Degeneration Open Access

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Deanna J. Taylor; Nicholas D. Smith; David P. Crabb

Tags: age-related macular degeneration, visual search, eye movement

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1887-1892. doi:10.1167/iovs.16-21122

Multidisciplinary Ophthalmic Imaging

Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms Open Access

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Qinqin Zhang; Chieh-Li Chen; Zhongdi Chu; Fang Zheng; Andrew Miller; Luiz Roisman; Joao Rafael de Oliveira Dias; Zohar Yehoshua; Karen B. Schaal; William Feuer; Giovanni Gregori; Sophie Kubach; Lin An; Paul F. Stetson; Mary K. Durbin; Philip J. Rosenfeld; Ruikang K. Wang

Tags: angiogram, choroidal neovascularization, comparative study research, diagnostic imaging

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1506-1513. doi:10.1167/iovs.16-20977

Correlation of Visually Evoked Functional and Blood Flow Changes in the Rat Retina Measured With a Combined OCT+ERG System Open Access

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Bingyao Tan; Erik Mason; Benjamin MacLellan; Kostadinka K. Bizheva

Tags: electroretinography, photic stimulation, photopsia, retina, vascular flow

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1673-1681. doi:10.1167/iovs.17-21543

Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility Open Access

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Katie A. Lucy; Bo Wang; Joel S. Schuman; Richard A. Bilonick; Yun Ling; Larry Kagemann; Ian A. Sigal; Ireneusz Grulkowski; Jonathan J. Liu; James G. Fujimoto; Hiroshi Ishikawa; Gadi Wollstein

Tags: body tissue, cribriform plate, eye, glaucoma, quality

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1751-1757. doi:10.1167/iovs.16-20784

Nantotechnology and Regenerative Medicine

Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice Open Access

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Benjamin J. Yungher; Márcio Ribeiro; Kevin K. Park

Tags: axon, axon guidance, mice, optic nerve, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1743-1750. doi:10.1167/iovs.16-19873

Physiology and Pharmacology

Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization Open Access

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Anna-Karina B. Maier; Sabrina Klein; Norbert Kociok; Aline I. Riechardt; Enken Gundlach; Nadine Reichhart; Olaf Strauß; Antonia M. Joussen

Tags: cornea, lymphangiogenesis, mice, neovascularization, pathologic, rna, messenger

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1387-1396. doi:10.1167/iovs.16-19249

The Relationship Between the Renin-Angiotensin–Aldosterone System and NMDA Receptor-Mediated Signal and the Prevention of Retinal Ganglion Cell Death Open Access

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Mamoru Kobayashi; Kazuyuki Hirooka; Aoi Ono; Yuki Nakano; Akira Nishiyama; Akitaka Tsujikawa

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1397-1403. doi:10.1167/iovs.16-21001

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration Open Access

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Joanne C. Wen; Ester Reina-Torres; Joseph M. Sherwood; Pratap Challa; Katy C. Liu; Guorong Li; Jason Y. H. Chang; Scott W. Cousins; Stefanie G. Schuman; Priyatham S. Mettu; W. Daniel Stamer; Darryl R. Overby; R. Rand Allingham

Tags: anti-vascular endothelial growth factor therapy, exudative age-related macular degeneration, injection of therapeutic agent, intraocular pressure, eye

Investigative Ophthalmology & Visual Science May 2017, Vol.58, 1893-1898. doi:10.1167/iovs.16-20786

VEGF as a Paracrine Regulator of Conventional Outflow Facility Open Access

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Ester Reina-Torres; Joanne C. Wen; Katy C. Liu; Guorong Li; Joseph M. Sherwood; Jason Y. H. Chang; Pratap Challa; Cassandra M. Flügel-Koch; W. Daniel Stamer; R. Rand Allingham; Darryl R. Overby

Tags: vascular endothelial growth factor a, vascular endothelial growth factor receptor-2, paracrine

Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1899-1908. doi:10.1167/iovs.16-20779

Retina

Long-term Characterization of Retinal Degeneration in Royal College of Surgeons Rats Using Spectral-Domain Optical Coherence Tomography Open Access

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Renee C. Ryals; Michael D. Andrews; Shreya Datta; Aaron S. Coyner; Cody M. Fischer; Yuquan Wen; Mark E. Pennesi; Trevor J. McGill

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1378-1386. doi:10.1167/iovs.16-20363

Contributions of Second- and Third-Order Retinal Neurons to Cone Electroretinograms After Loss of Rod Function in Rhodopsin P347L Transgenic Rabbits Open Access

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Taro Kominami; Shinji Ueno; Satoshi Okado; Ayami Nakanishi; Mineo Kondo; Hiroko Terasaki

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1417-1424. doi:10.1167/iovs.16-20344

Intravitreally Injected Fluid Dispersion: Importance of Injection Technique Open Access

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Koen Willekens; Geert Reyns; Marjan Diricx; Marc Vanhove; Bernard Noppen; Walter Coudyzer; Yicheng Ni; Jean H. M. Feyen; Peter Stalmans

Tags: eye, injection of therapeutic agent, vitreous body, needle device

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1434-1441. doi:10.1167/iovs.16-20543

Comparison Between Spectral-Domain and Swept-Source Optical Coherence Tomography Angiographic Imaging of Choroidal Neovascularization Open Access

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Andrew R. Miller; Luiz Roisman; Qinqin Zhang; Fang Zheng; Joao Rafael de Oliveira Dias; Zohar Yehoshua; Karen B. Schaal; William Feuer; Giovanni Gregori; Zhongdi Chu; Chieh-Li Chen; Sophie Kubach; Lin An; Paul F. Stetson; Mary K. Durbin; Ruikang K. Wang; Philip J. Rosenfeld

Tags: angiogram, choroidal neovascularization, diagnostic imaging, optical coherence tomography

Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1499-1505. doi:10.1167/iovs.16-20969

Intraocular Delivery of miR-146 Inhibits Diabetes-Induced Retinal Functional Defects in Diabetic Rat Model Open Access

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Pei Zhuang; Chithra K. Muraleedharan; Shunbin Xu

Tags: diabetes mellitus, retina, rats, retinal perforations, diabetes mellitus, type 2

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1646-1655. doi:10.1167/iovs.16-21223

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome Open Access

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Dario Marangoni; Zeng Yong; Sten Kjellström; Camasamudram Vijayasarathy; Paul A. Sieving; Ronald A. Bush

Tags: gene therapy, light intensity, mice, x-linked retinoschisis, electroretinography

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1656-1664. doi:10.1167/iovs.16-21016

Arap1 Deficiency Causes Photoreceptor Degeneration in Mice Open Access

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Ala Moshiri; Devin Humpal; Brian C. Leonard; Denise M. Imai; Addy Tham; Lynette Bower; Dave Clary; Thomas M. Glaser; K. C. Kent Lloyd; Christopher J. Murphy

Tags: mice, photoreceptors, tissue degeneration, retina, immunohistochemistry

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1709-1718. doi:10.1167/iovs.16-20062

Recurrence of Retinopathy of Prematurity After Intravitreal Ranibizumab Monotherapy: Timing and Risk Factors Open Access

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Jiao Lyu; Qi Zhang; Chun-Li Chen; Yu Xu; Xun-Da Ji; Jia-Kai Li; Qiu-Jing Huang; Pei-Quan Zhao

Tags: ranibizumab, recurrence, retinopathy of prematurity, risk factors

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1719-1725. doi:10.1167/iovs.16-20680

MicroRNA Expression Patterns Involved in Amyloid Beta–Induced Retinal Degeneration Open Access

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Peirong Huang; Junran Sun; Fenghua Wang; Xueting Luo; Jingyang Feng; Qing Gu; Te Liu; Xiaodong Sun

Tags: micrornas, retinal degeneration, amyloid beta-protein

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1726-1735. doi:10.1167/iovs.16-20043

Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury Open Access

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Jianhui Xiao; Jingyu Yao; Lin Jia; Chengmao Lin; David N. Zacks

Tags: iodates, peptides, photoreceptors, retina, retinal pigment epithelium

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1801-1810. doi:10.1167/iovs.16-21392

Quantifying Fundus Autofluorescence in Patients With Retinitis Pigmentosa Open Access

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Kaspar Schuerch; Russell L. Woods; Winston Lee; Tobias Duncker; François C. Delori; Rando Allikmets; Stephen H. Tsang; Janet R. Sparrow

Tags: eye, fundus autofluorescence imaging, retinitis pigmentosa

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1843-1855. doi:10.1167/iovs.16-21302

Retinal Cell Biology

Subretinal Glial Membranes in Eyes With Geographic Atrophy Open Access

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Malia M. Edwards; D. Scott McLeod; Imran A. Bhutto; Rhonda Grebe; Maeve Duffy; Gerard A. Lutty

Tags: atrophic condition of skin, atrophy, embryonic lethal mutation, eye, neuroglia

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1352-1367. doi:10.1167/iovs.16-21229

Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes Open Access

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James B. Stanton; Alan D. Marmorstein; Youwen Zhang; Lihua Y. Marmorstein

Tags: cigarette smoke, eye, mice, lasers, argon laser

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1455-1461. doi:10.1167/iovs.16-20955

Visual Neuroscience

The Relation Between Light-Induced Lacrimation and the Melanopsin-Driven Postillumination Pupil Response Open Access

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Shaobo Lei; Herbert C. Goltz; Xingqiao Chen; Marija Zivcevska; Agnes M. F. Wong

Tags: melanopsin, pupil reaction, tear production

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1449-1454. doi:10.1167/iovs.16-21285

Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION) Open Access

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Tzu-Lun Huang; Yao-Tseng Wen; Chung-Hsing Chang; Shu-Wen Chang; Kuan-Hung Lin; Rong-Kung Tsai

Tags: anterior ischemic optic neuropathy, cytokine, methylprednisolone, neurons, optics

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1628-1636. doi:10.1167/iovs.16-21017

LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells Open Access

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Marion Neuillé; Yan Cao; Romain Caplette; Debbie Guerrero-Given; Connon Thomas; Naomi Kamasawa; José-Alain Sahel; Christian P. Hamel; Isabelle Audo; Serge Picaud; Kirill A. Martemyanov; Christina Zeitz

Tags: mice, retinal bipolar cells, retinal cone, synapses, synaptic transmission

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1768-1778. doi:10.1167/iovs.16-20745

Visual Psychophysics and Physiological Optics

Accommodation Responds to Optical Vergence and Not Defocus Blur Alone Open Access

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Antonio J. Del Águila-Carrasco; Iván Marín-Franch; Paula Bernal-Molina; José J. Esteve-Taboada; Philip B. Kruger; Robert Montés-Micó; Norberto López-Gil

Tags: optics, visual accommodation

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1758-1763. doi:10.1167/iovs.16-21280

Clinical Trials

Functional Outcomes of the Low Vision Depression Prevention Trial in Age-Related Macular Degeneration Open Access

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Ashley D. Deemer; Robert W. Massof; Barry W. Rovner; Robin J. Casten; Catherine V. Piersol

Tags: age-related macular degeneration, depressive disorders, prevention, visual impairment

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1514-1520. doi:10.1167/iovs.16-20001

Review

The Retinal Relaxing Factor: Update on an Enigmatic Regulator of the Retinal Circulation Open Access

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Laura Vanden Daele; Charlotte Boydens; Bart Pauwels; Johan Van de Voorde

Tags: adenosine, body tissue, cattle, central retinal artery, hypoxia

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1702-1708. doi:10.1167/iovs.16-20904

Unilateral Amblyopia Affects Two Eyes: Fellow Eye Deficits in Amblyopia Open Access

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Kimberly Meier; Deborah Giaschi

Tags: amblyopia, eye, contrast sensitivity

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1779-1800. doi:10.1167/iovs.16-20964

Letters to the Editor

Adipose-Derived Mesenchymal Stem Cells Reduce Lymphocytic Infiltration in a Rabbit Model of Induced Autoimmune Dacryoadenitis: Some Discussions Open Access

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Ying Liu

Tags: autoimmunity, dacryoadenitis, lymphocyte, oryctolagus cuniculus, stem cell, mesenchymal

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1585. doi:10.1167/iovs.17-21694

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization Open Access

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Scott W. Canna; Guangpu Shi; Igal Gery; H. Nida Sen

Tags: choroidal neovascularization, interleukin-18, macular degeneration

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1764-1765. doi:10.1167/iovs.17-21697

Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy Open Access

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Fangyao Tang; Carol Y. Cheung

Tags: angiogram, diabetes mellitus, diabetic retinopathy, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1766. doi:10.1167/iovs.17-21552

Author Response: Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy Open Access

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Galina Dimitrova; Etsuo Chihara; Hirokazu Takahashi; Hiroyuki Amano; Kazushiro Okazaki

Tags: angiogram, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1767. doi:10.1167/iovs.17-21706

Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab Open Access

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Mohammed Ashraf

Tags: exudative retinal detachment, macular edema, diabetic, ranibizumab

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1856. doi:10.1167/iovs.17-21655

Author Response: Functional and Anatomic Outcomes in Patients With Serous Retinal Detachment in Diabetic Macular Edema Treated With Ranibizumab Open Access

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Audrey Giocanti-Auregan; Franck Fajnkuchen

Tags: exudative retinal detachment, macular edema, diabetic, ranibizumab

Investigative Ophthalmology & Visual Science March 2017, Vol.58, 1857. doi:10.1167/iovs.17-21726

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