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Research Highlight

Fibrillin Microfibrils Keep the Cornea in Shape Open Access
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Shukti Chakravarti
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2117. doi:https://doi.org/10.1167/iovs.17-21840
Bright Light Blocks the Development of Form Deprivation Myopia in Mice, Acting on D1 Dopamine Receptors Open Access
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Ian G. Morgan; Regan S. Ashby
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2317. doi:https://doi.org/10.1167/iovs.17-21871

Anatomy and Pathology/Oncology

Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure Open Access
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Andrew J. Feola; Baptiste Coudrillier; John Mulvihill; Diogo M. Geraldes; Nghia T. Vo; Julie Albon; Richard L. Abel; Brian C. Samuels; C. Ross Ethier
Tags: cerebrospinal fluid pressure, cribriform plate, optic nerve, body tissue, eye
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2070-2078. doi:https://doi.org/10.1167/iovs.16-21393

Biochemistry and Molecular Biology

Reduced Scleral TIMP-2 Expression Is Associated With Myopia Development: TIMP-2 Supplementation Stabilizes Scleral Biomarkers of Myopia and Limits Myopia Development Open Access
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Hsin-Hua Liu; Megan S. Kenning; Andrew I. Jobling; Neville A. McBrien; Alex Gentle
Tags: gelatinase a, myopia, sclera, timp2 protein, human, collagen
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1971-1981. doi:https://doi.org/10.1167/iovs.16-21181
High Mitochondrial DNA Copy Number Is a Protective Factor From Vision Loss in Heteroplasmic Leber's Hereditary Optic Neuropathy (LHON) Open Access
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Angelica Bianco; Luigi Bisceglia; Luciana Russo; Luigi L. Palese; Leonardo D'Agruma; Sonia Emperador; Julio Montoya; Silvana Guerriero; Vittoria Petruzzella
Tags: blindness, dna, mitochondrial, optic atrophy, hereditary, leber, protective factors
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2193-2197. doi:https://doi.org/10.1167/iovs.16-20389
Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium Open Access
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Sujoy Bhattacharya; Jinggang Yin; Christina S. Winborn; Qiuhua Zhang; Junming Yue; Edward Chaum
Tags: autophagy, mtor serine-threonine kinases, signal transduction, ac133 antigen, retinal pigment cell
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2366-2387. doi:https://doi.org/10.1167/iovs.16-21162

Clinical and Epidemiologic Research

Vitreomacular Adhesion and Its Association With Age-Related Macular Degeneration in a Population-Based Setting: The Alienor Study Open Access
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Sarra Gattoussi; Audrey Cougnard-Grégoire; Marie-Noëlle Delyfer; Marie-Bénédicte Rougier; Cédric Schweitzer; Cécile Delcourt; Jean-François Korobelnik
Tags: age-related macular degeneration, spectral domain-optical coherence tomography, vitreomacular adhesions, cataract surgery, risk factors
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2180-2186. doi:https://doi.org/10.1167/iovs.16-20741
Visual Impairment, Undercorrected Refractive Errors, and Activity Limitations in Older Adults: Findings From the Three-City Alienor Study Open Access
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Virginie Naël; Karine Pérès; Isabelle Carrière; Vincent Daien; Anne-Catherine Scherlen; Angelo Arleo; Jean-Francois Korobelnik; Cécile Delcourt; Catherine Helmer
Tags: older adult, refractive errors, visual impairment, visual acuity, social participation
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2359-2365. doi:https://doi.org/10.1167/iovs.17-21525

Cornea

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy Open Access
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Munetoyo Toda; Morio Ueno; Asako Hiraga; Kazuko Asada; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Tags: cd44 antigens, cell therapy, cornea, endothelial cells, homing-associated cell adhesion molecule
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2011-2020. doi:https://doi.org/10.1167/iovs.16-20703
Optimum Laser Beam Characteristics for Achieving Smoother Ablations in Laser Vision Correction Open Access
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Shwetabh Verma; Juergen Hesser; Samuel Arba-Mosquera
Tags: ablation, lasers, vision
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2021-2037. doi:https://doi.org/10.1167/iovs.16-21025
The Structural Role of Elastic Fibers in the Cornea Investigated Using a Mouse Model for Marfan Syndrome Open Access
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Tomas L. White; Philip Lewis; Sally Hayes; James Fergusson; James Bell; Luis Farinha; Nick S. White; Lygia V. Pereira; Keith M. Meek
Tags: cornea, elastic fibers, fibrillin-1, marfan syndrome, mice
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2106-2116. doi:https://doi.org/10.1167/iovs.16-21358
Mitochondrial and Morphologic Alterations in Native Human Corneal Endothelial Cells Associated With Diabetes Mellitus Open Access
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Benjamin T. Aldrich; Ursula Schlötzer-Schrehardt; Jessica M. Skeie; Kimberlee A. Burckart; Gregory A. Schmidt; Cynthia R. Reed; M. Bridget Zimmerman; Friedrich E. Kruse; Mark A. Greiner
Tags: cornea, diabetes mellitus, endothelial cells, mitochondria, donors
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2130-2138. doi:https://doi.org/10.1167/iovs.16-21094
Suppression by an RAR-γ Agonist of Collagen Degradation Mediated by Corneal Fibroblasts Open Access
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Kazuhiro Kimura; Hongyan Zhou; Tomoko Orita; Masaaki Kobayashi; Teruo Nishida; Koh-Hei Sonoda
Tags: agonists, collagen, cornea, fibroblasts, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2250-2257. doi:https://doi.org/10.1167/iovs.15-18701
Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study Open Access
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Jianzhong Chen; Jeremy K. Keirsey; Kari B. Green; Kelly K. Nichols
Tags: dry eye syndromes, lipids, fasting lipid profile, pilot projects, gene expression profiling
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2266-2274. doi:https://doi.org/10.1167/iovs.16-20902
Enhanced Tearing by Electrical Stimulation of the Anterior Ethmoid Nerve Open Access
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Mark Brinton; Andrea L. Kossler; Zara M. Patel; James Loudin; Manfred Franke; Christopher N. Ta; Daniel Palanker
Tags: bodily secretions, electric stimulation, ethmoid bone, lipids, neurons
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2341-2348. doi:https://doi.org/10.1167/iovs.16-21362
Correlation Between the Inflammatory Marker HLA-DR and Signs and Symptoms in Moderate to Severe Dry Eye Disease Open Access
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Françoise Brignole-Baudouin; Luisa Riancho; Dahlia Ismail; Maëva Deniaud; Mourad Amrane; Christophe Baudouin
Tags: dry eye syndromes, hla-dr antigens, signs and symptoms, inflammatory markers
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2438-2448. doi:https://doi.org/10.1167/iovs.15-16555

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Open Access
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Ming-Hui Sun; Mohammad Ali Shariati; Yaping Joyce Liao
Tags: diabetes mellitus, edema, mice, vascular endothelial growth factor a, anterior ischemic optic neuropathy
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2296-2305. doi:https://doi.org/10.1167/iovs.16-20308
Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina Open Access
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Si Chen; Zhina Zhi; Qingqing Ruan; Qingxia Liu; Fen Li; Fen Wan; Peter S. Reinach; Jiangfan Chen; Jia Qu; Xiangtian Zhou
Tags: abdominal compartment syndrome, acute coronary syndromes, dopamine d1 receptor, myopia, retina
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2306-2316. doi:https://doi.org/10.1167/iovs.16-20402
Regional Extent of Peripheral Suppression in Amblyopia Open Access
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Raiju J. Babu; Simon Clavagnier; William R. Bobier; Benjamin Thompson; Robert F. Hess
Tags: amblyopia, strabismus, eye
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2329-2340. doi:https://doi.org/10.1167/iovs.16-20012
Ocular Motor Nerve Development in the Presence and Absence of Extraocular Muscle Open Access
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Suzanne M. Michalak; Mary C. Whitman; Jong G. Park; Max A. Tischfield; Elaine H. Nguyen; Elizabeth C. Engle
Tags: embryo, motor nerve, motor neurons, muscle, muscle of orbit
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2388-2396. doi:https://doi.org/10.1167/iovs.16-21268

Genetics

Exome Sequence Analysis of 14 Families With High Myopia Open Access
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Bethany A. Kloss; Stuart W. Tompson; Kristina N. Whisenhunt; Krystina L. Quow; Samuel J. Huang; Derek M. Pavelec; Thomas Rosenberg; Terri L. Young
Tags: exome, family, myopia, genetic analysis, sequence analysis
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1982-1990. doi:https://doi.org/10.1167/iovs.16-20883
miRNA Copy Number Variants Confer Susceptibility to Acute Anterior Uveitis With or Without Ankylosing Spondylitis Open Access
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Lu Yang; Liping Du; Yingying Yue; Yike Huang; Qingyun Zhou; Shuang Cao; Jian Qi; Liang Liang; Lili Wu; Chaokui Wang; Zi Ye; Yuan Tian; Aize Kijlstra; Shengping Hou; Peizeng Yang
Tags: ankylosing spondylitis, copy number polymorphism, disease susceptibility, micrornas, uveitis, anterior
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1991-2001. doi:https://doi.org/10.1167/iovs.16-21047
Molecular Genetic Analysis of Pakistani Families With Autosomal Recessive Congenital Cataracts by Homozygosity Screening Open Access
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Jianjun Chen; Qiwei Wang; Patricia E. Cabrera; Zilin Zhong; Wenmin Sun; Xiaodong Jiao; Yabin Chen; Gowthaman Govindarajan; Muhammad Asif Naeem; Shaheen N. Khan; Muhammad Hassaan Ali; Muhammad Zaman Assir; Fawad Ur Rahman; Zaheeruddin A. Qazi; Sheikh Riazuddin; Javed Akram; S. Amer Riazuddin; J. Fielding Hejtmancik
Tags: autosomal recessive inheritance, cataract, congenital cataract, family, homozygote
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2207-2217. doi:https://doi.org/10.1167/iovs.17-21469
Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families Open Access
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Lin Li; Yabin Chen; Xiaodong Jiao; Chongfei Jin; Dan Jiang; Mukesh Tanwar; Zhiwei Ma; Li Huang; Xiaoyin Ma; Wenmin Sun; Jianjun Chen; Yan Ma; Oussama M'hamdi; Gowthaman Govindarajan; Patricia E. Cabrera; Jiali Li; Nikhil Gupta; Muhammad Asif Naeem; Shaheen N. Khan; Sheikh Riazuddin; Javed Akram; Radha Ayyagari; Paul A. Sieving; S. Amer Riazuddin; J. Fielding Hejtmancik
Tags: family, homozygote, retinal dystrophies, autosomal recessive inheritance, mutation
Investigative Ophthalmology & Visual Science May 2017, Vol.58, 2218-2238. doi:https://doi.org/10.1167/iovs.17-21424
Whole Exome Sequencing in Eight Thai Patients With Leber Congenital Amaurosis Reveals Mutations in the CTNNA1 and CYP4V2 Genes Open Access
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Worapoj Jinda; Todd D. Taylor; Yutaka Suzuki; Wanna Thongnoppakhun; Chanin Limwongse; Patcharee Lertrit; Adisak Trinavarat; La-Ongsri Atchaneeyasakul
Tags: genes, leber's amaurosis, mutation, whole exome sequencing, thai
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2413-2420. doi:https://doi.org/10.1167/iovs.16-21322

Glaucoma

Predictions of Optic Nerve Traction Forces and Peripapillary Tissue Stresses Following Horizontal Eye Movements Open Access
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Xiaofei Wang; Liam K. Fisher; Dan Milea; Jost B. Jonas; Michaël J. A. Girard
Tags: body tissue, eye movement, optic nerve, traction, stress
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2044-2053. doi:https://doi.org/10.1167/iovs.16-21319
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma Open Access
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Wei Zhu; Ankur Jain; Oliver W. Gramlich; Budd A. Tucker; Val C. Sheffield; Markus H. Kuehn
Tags: aqueous humor, glaucoma, intraocular pressure, mice, mice, transgenic
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2054-2062. doi:https://doi.org/10.1167/iovs.16-20672
Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton Open Access
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Xiang-Run Huang; Robert W. Knighton; Ye Z. Spector; Jianzhong Qiao; Wei Kong; Qi Zhao
Tags: birefringence, cytoskeleton, glaucoma, hypertension, optics
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2118-2129. doi:https://doi.org/10.1167/iovs.16-20553
Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability Open Access
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Goutham R. Adelli; Prakash Bhagav; Pranjal Taskar; Tushar Hingorani; Sara Pettaway; Waseem Gul; Mahmoud A. ElSohly; Michael A. Repka; Soumyajit Majumdar
Tags: prodrugs, tetrahydrocannabinol, body tissue
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2167-2179. doi:https://doi.org/10.1167/iovs.16-20757
Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma Open Access
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Yuka Aoyama-Araki; Megumi Honjo; Takatoshi Uchida; Reiko Yamagishi; Kuniyuki Kano; Junken Aoki; Makoto Aihara
Tags: antagonists, collagen, conjunctiva, fibroblasts, fibrosis
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2258-2265. doi:https://doi.org/10.1167/iovs.16-21288
Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA) Open Access
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Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Utako Kuroda; Miyuki Inoue-Mochita; Eri Takahashi; Saori Ohira; Hidenobu Tanihara
Tags: vorinostat, blister, filtration
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2421-2429. doi:https://doi.org/10.1167/iovs.16-21403
Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma Open Access
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Raymond P. Najjar; Sourabh Sharma; Morgane Drouet; Stephanie Leruez; Mani Baskaran; Monisha E. Nongpiur; Tin Aung; Joanne Fielding; Owen White; Michael J. Girard; Cédric Lamirel; Dan Milea
Tags: eye movement, open-angle glaucoma, saccades
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2430-2437. doi:https://doi.org/10.1167/iovs.16-21002

Immunology and Microbiology

Cytokines and Chemokines Involved in Acute Retinal Necrosis Open Access
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L. de Visser; J.H. de Boer; G.T. Rijkers; K. Wiertz; H.J. van den Ham; R. de Boer; A.M. van Loon; A. Rothova; D. F. de Groot-Mijnes
Tags: chemokines, cytokine, immune mediator, retinal necrosis syndrome, acute
Investigative Ophthalmology & Visual Science May 2017, Vol.58, 2139-2151. doi:https://doi.org/10.1167/iovs.16-20799

Lens

Forkhead Box Protein P1 Is Dispensable for Retina but Essential for Lens Development Open Access
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Haruna Suzuki-Kerr; Yukihiro Baba; Asano Tsuhako; Hideto Koso; Joseph D. Dekker; Haley O. Tucker; Hiroshi Kuribayashi; Sumiko Watanabe
Tags: lens (device), lens, crystalline, proteins, retina, mice
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1916-1929. doi:https://doi.org/10.1167/iovs.16-20085
Multiple Aggregation Pathways in Human γS-Crystallin and Its Aggregation-Prone G18V Variant Open Access
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Kyle W. Roskamp; David M. Montelongo; Chelsea D. Anorma; Diana N. Bandak; Janine A. Chua; Kurtis T. Malecha; Rachel W. Martin
Tags: crystallins, fluorescence, proteins, thioflavin t, ultraviolet rays
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2397-2405. doi:https://doi.org/10.1167/iovs.16-20621

Physiology and Pharmacology

Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy Open Access
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Phillip A. Vanlandingham; Didier J. Nuno; Alexander B. Quiambao; Eric Phelps; Ronald A. Wassel; Jian-Xing Ma; Krysten M. Farjo; Rafal A. Farjo
Tags: blindness, diabetes mellitus, diabetic retinopathy, rats, small molecule
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2095-2105. doi:https://doi.org/10.1167/iovs.16-20641
The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells Open Access
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Sandipan Datta; Christophe Baudouin; Francoise Brignole-Baudouin; Alexandre Denoyer; Gino A. Cortopassi
Tags: benzalkonium chloride, eyedrops, mitochondria, optic atrophy, hereditary, leber, pathophysiology
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2406-2412. doi:https://doi.org/10.1167/iovs.16-20903

Retina

Choroidal Vascular Flow Area in Central Serous Chorioretinopathy Using Swept-Source Optical Coherence Tomography Angiography Open Access
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Massimo Nicolò; Raffaella Rosa; Donatella Musetti; Maria Musolino; Michela Saccheggiani; Carlo Enrico Traverso
Tags: angiogram, central serous chorioretinopathy, eye, fluid flow, optical coherence tomography
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2002-2010. doi:https://doi.org/10.1167/iovs.17-21417
Gap in Capillary Perfusion on Optical Coherence Tomography Angiography Associated With Persistent Macular Edema in Branch Retinal Vein Occlusion Open Access
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Kotaro Tsuboi; Yuichiro Ishida; Motohiro Kamei
Tags: angiogram, blood capillaries, edema, optical coherence tomography, perfusion
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2038-2043. doi:https://doi.org/10.1167/iovs.17-21447
Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes Open Access
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Mayss Al-Sheikh; Nopasak Phasukkijwatana; Rosa Dolz-Marco; Mansour Rahimi; Nicholas A. Iafe; K. Bailey Freund; SriniVas R. Sadda; David Sarraf
Tags: angiogram, chief complaint, eye, fluid flow, myopia
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2063-2069. doi:https://doi.org/10.1167/iovs.16-21289
Quantitative Analysis of the Ellipsoid Zone Intensity in Phenotypic Variations of Intermediate Age-Related Macular Degeneration Open Access
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Thomas J. Gin; Zhichao Wu; Sky K. H. Chew; Robyn H. Guymer; Chi D. Luu
Tags: age-related macular degeneration, drusen, eye, phenotype, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2079-2086. doi:https://doi.org/10.1167/iovs.16-20105
Retinal Microvasculature and Visual Acuity in Eyes With Branch Retinal Vein Occlusion: Imaging Analysis by Optical Coherence Tomography Angiography Open Access
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Taku Wakabayashi; Tatsuhiko Sato; Chikako Hara-Ueno; Yoko Fukushima; Kaori Sayanagi; Nobuhiko Shiraki; Miki Sawa; Yasushi Ikuno; Hirokazu Sakaguchi; Kohji Nishida
Tags: angiogram, diagnostic imaging, edema, eye, optical coherence tomography
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2087-2094. doi:https://doi.org/10.1167/iovs.16-21208
Multimodal Fundus Imaging of Sodium Iodate-Treated Mice Informs RPE Susceptibility and Origins of Increased Fundus Autofluorescence Open Access
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Jin Zhao; Hye Jin Kim; Janet R. Sparrow
Tags: diagnostic imaging, disease susceptibility, iodates, mice, sodium
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2152-2159. doi:https://doi.org/10.1167/iovs.17-21557
Loss of Melanopsin-Expressing Retinal Ganglion Cells in Patients With Diabetic Retinopathy Open Access
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Elisabeth Anne Obara; Jens Hannibal; Steffen Heegaard; Jan Fahrenkrug
Tags: diabetic retinopathy, melanopsin, retinal ganglion cells, retina
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2187-2192. doi:https://doi.org/10.1167/iovs.16-21168
Prevalence, Natural Course, and Prognostic Role of Refractile Drusen in Age-Related Macular Degeneration Open Access
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Akio Oishi; Sarah Thiele; Jennifer Nadal; Maho Oishi; Monika Fleckenstein; Matthias Schmid; Frank G. Holz; Steffen Schmitz-Valckenberg
Tags: drusen, age-related macular degeneration, patient prognosis
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2198-2206. doi:https://doi.org/10.1167/iovs.16-20781
Course of Sodium Iodate–Induced Retinal Degeneration in Albino and Pigmented Mice Open Access
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Guy Chowers; Matan Cohen; Devora Marks-Ohana; Shelly Stika; Ayala Eijzenberg; Eyal Banin; Alexey Obolensky
Tags: albinism, iodates, mice, retinal degeneration, sodium
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2239-2249. doi:https://doi.org/10.1167/iovs.16-21255
Macular Pigment Density and Quantitative Fundus Autofluorescence in Young Healthy Subjects Open Access
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Chiara M. Eandi; Marco Nassisi; Carlo Lavia; Camilla Alovisi; Ugo de Sanctis
Tags: eye, fundus autofluorescence imaging, macular pigment, mucopolysaccharidosis ii
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2284-2290. doi:https://doi.org/10.1167/iovs.16-20510
Automated Staging of Age-Related Macular Degeneration Using Optical Coherence Tomography Open Access
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Freerk G. Venhuizen; Bram van Ginneken; Freekje van Asten; Mark J. J. P. van Grinsven; Sascha Fauser; Carel B. Hoyng; Thomas Theelen; Clara I. Sánchez
Tags: age-related macular degeneration, machine learning, optical coherence tomography, datasets, volume
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2318-2328. doi:https://doi.org/10.1167/iovs.16-20541
The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy Open Access
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Anna C. S. Tan; Polina Astroz; Kunal K. Dansingani; Jason S. Slakter; Lawrence A. Yannuzzi; Christine A. Curcio; K. Bailey Freund
Tags: atrophy, diagnostic imaging, eye, optical coherence tomography, volume
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2349-2358. doi:https://doi.org/10.1167/iovs.16-21237

Retinal Cell Biology

Organotypic Cultures of Adult Mouse Retina: Morphologic Changes and Gene Expression Open Access
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Brigitte Müller; Franziska Wagner; Birgit Lorenz; Knut Stieger
Tags: adult, gene expression, mice, retina, in situ nick-end labeling
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1930-1940. doi:https://doi.org/10.1167/iovs.16-20718
Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells Open Access
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Annaïg Hamon; Christel Masson; Juliette Bitard; Linn Gieser; Jérôme E. Roger; Muriel Perron
Tags: retina, retinal degeneration, rna, photoreceptors, precipitating factors
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1941-1953. doi:https://doi.org/10.1167/iovs.16-21366
Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice Open Access
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Xuezhi Cui; Soumya Navneet; Jing Wang; Penny Roon; Wei Chen; Ming Xian; Sylvia B. Smith
Tags: glutathione, hydrogen sulfide, hyperhomocysteinemia, methylenetetrahydrofolate reductase (nadph2), mice
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1954-1963. doi:https://doi.org/10.1167/iovs.16-21247
Noninvasive Quantification of Retinal Microglia Using Widefield Autofluorescence Imaging Open Access
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Despina Kokona; Nadia Schneider; Helena Giannakaki-Zimmermann; Joel Jovanovic; Andreas Ebneter; Martin Zinkernagel
Tags: autofluorescence, diagnostic imaging, microglia, lens (device), retina
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2160-2165. doi:https://doi.org/10.1167/iovs.16-20916

Visual Psychophysics and Physiological Optics

Micrometric Control of the Optics of the Human Eye: Environment or Genes? Open Access
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Juan Tabernero; Lucía Hervella; Antonio Benito; Lucía Colodro-Conde; Juan R. Ordoñana; Marcos Ruiz-Sanchez; José María Marín; Pablo Artal
Tags: cornea, eye, genes, optics, twins
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 1964-1970. doi:https://doi.org/10.1167/iovs.16-20957
Contrast Sensitivity and Lateral Inhibition Are Enhanced With Macular Carotenoid Supplementation Open Access
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James M. Stringham; Kevin J. O'Brien; Nicole T. Stringham
Tags: carotenoids, contrast sensitivity, macular pigment, placebos
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2291-2295. doi:https://doi.org/10.1167/iovs.16-21087

Clinical Trials

A New Viscous Cysteamine Eye Drops Treatment for Ophthalmic Cystinosis: An Open-Label Randomized Comparative Phase III Pivotal Study Open Access
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Hong Liang; Antoine Labbé; Jeannie Le Mouhaër; Céline Plisson; Christophe Baudouin
Tags: cysteamine, cystinosis, eye, eyedrops, phase 3 clinical trials
Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2275-2283. doi:https://doi.org/10.1167/iovs.16-21080

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science April 2017, Vol.58, 2166. doi:https://doi.org/10.1167/iovs.16-20969a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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