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Editorial

Foreword: Biomarkers and Surrogate Endpoints in Ophthalmic Clinical Research Open Access
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Edoardo Villani; Stela Vujosevic
Tags: biological markers, clinical research, eye, surrogate endpoints
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIOi-BIOii. doi:https://doi.org/10.1167/iovs.17-22128

Special Issue

The Growing Need for Validated Biomarkers and Endpoints for Dry Eye Clinical Research Open Access
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Neeta S. Roy; Yi Wei; Eric Kuklinski; Penny A. Asbell
Tags: biological markers, dry eye syndromes, surrogate endpoints, clinical research
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO1-BIO19. doi:https://doi.org/10.1167/iovs.17-21709
Biomarkers and Surrogate Endpoints: Lessons Learned From Glaucoma Open Access
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Felipe A. Medeiros
Tags: biological markers, glaucoma, surrogate endpoints
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO20-BIO26. doi:https://doi.org/10.1167/iovs.17-21987
Biomarkers and Surrogate Endpoints in Drug Development: A European Regulatory View Open Access
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Kerstin Wickström; Jane Moseley
Tags: biological markers, drug development, surrogate endpoints
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO27-BIO33. doi:https://doi.org/10.1167/iovs.17-21778
CRISPR/Cas9–Mediated Mutation of αA-Crystallin Gene Induces Congenital Cataracts in Rabbits Open Access
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Lin Yuan; Haobin Yao; Yuxin Xu; Mao Chen; Jichao Deng; Yuning Song; Tingting Sui; Yong Wang; Yongye Huang; Zhanjun Li; Liangxue Lai
Tags: congenital cataract, crispr, crystallins, mutation, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO34-BIO41. doi:https://doi.org/10.1167/iovs.16-21287
Iris Damage Is Associated With Elevated Cytokine Levels in Aqueous Humor Open Access
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Naohiko Aketa; Takefumi Yamaguchi; Terumasa Suzuki; Kazunari Higa; Yukari Yagi-Yaguchi; Yoshiyuki Satake; Kazuo Tsubota; Jun Shimazaki
Tags: cytokine, immune reconstitution inflammatory syndrome, iris, proteins, eye
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO42-BIO51. doi:https://doi.org/10.1167/iovs.17-21421
Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain Open Access
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Daniel A. Culver; Albert Dahan; Daiva Bajorunas; Maria Jeziorska; Monique van Velzen; Leon P. H. J. Aarts; Jinny Tavee; Martijn R. Tannemaat; Ann N. Dunne; Rita I. Kirk; Ioannis N. Petropoulos; Anthony Cerami; Rayaz A. Malik; Michael Brines
Tags: cornea, nerve fibers, neuropathic pain, neuropathy, small-fiber, sarcoidosis
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO52-BIO60. doi:https://doi.org/10.1167/iovs.16-21291
Combined Fundus Autofluorescence and Near Infrared Reflectance as Prognostic Biomarkers for Visual Acuity in Foveal-Sparing Geographic Atrophy Open Access
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Moritz Lindner; Jennifer Nadal; Matthias M. Mauschitz; Anna Lüning; Joanna Czauderna; Maximilian Pfau; Steffen Schmitz-Valckenberg; Frank G. Holz; Matthias Schmid; Monika Fleckenstein
Tags: atrophy, eye, fovea centralis, fundus autofluorescence imaging, prognostic marker
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO61-BIO67. doi:https://doi.org/10.1167/iovs.16-21210
Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach Open Access
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Stela Vujosevic; Rafael Simó
Tags: biological markers, cytokine, diabetic retinopathy, inflammation, inflammatory markers
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO68-BIO75. doi:https://doi.org/10.1167/iovs.17-21769
Decade-Long Profile of Imaging Biomarker Use in Ophthalmic Clinical Trials Open Access
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Edoardo Villani; Domenico Massaro; Matteo Scaramuzzi; Pedram Hamrah; Felipe A. Medeiros; Paolo Nucci
Tags: biological markers, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO76-BIO81. doi:https://doi.org/10.1167/iovs.17-21790
Retinal Vein Occlusion as the Surrogate Marker for Premature Brain Aging in Young Patients Open Access
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Kwan Hyuk Cho; Chi Kyung Kim; Kyungmi Oh; Seung-Won Oh; Kyu Hyung Park; Sang Jun Park
Tags: aging, brain, brain mri, retinal vein occlusion, small-vessel vasculitis
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO82-BIO87. doi:https://doi.org/10.1167/iovs.17-21413
Omics Biomarkers in Ophthalmology Open Access
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Susette Lauwen; Eiko K. de Jong; Dirk J. Lefeber; Anneke I. den Hollander
Tags: biological markers, ophthalmology, proteins, genome, glaucoma
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO88-BIO98. doi:https://doi.org/10.1167/iovs.17-21809
Model for Risk-Based Screening of Diabetic Retinopathy in People With Newly-Diagnosed Type 2 Diabetes Mellitus Open Access
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Irini Chatziralli; Theodoros N. Sergentanis; Roxanne Crosby-Nwaobi; Kirsty Winkley; Haralabos Eleftheriadis; Khalida Ismail; Stephanie A. Amiel; Sobha Sivaprasad
Tags: biological markers, diabetes mellitus, type 2, diabetic retinopathy, screening
Investigative Ophthalmology & Visual Science May 2017, Vol.58, BIO99-BIO105. doi:https://doi.org/10.1167/iovs.17-21713
Functional Activity of Matrix Metalloproteinases 2 and 9 in Tears of Patients With Glaucoma Open Access
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Prity Sahay; Aparna Rao; Debananda Padhy; Sarada Sarangi; Gopinath Das; Mamatha M. Reddy; Rahul Modak
Tags: gelatinase b, glaucoma, matrix metalloproteinases, gelatin, tear film finding
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO106-BIO113. doi:https://doi.org/10.1167/iovs.17-21723
In Vivo Confocal Imaging of the Conjunctiva as a Predictive Tool for the Glaucoma Filtration Surgery Outcome Open Access
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Rodolfo Mastropasqua; Vincenzo Fasanella; Lorenza Brescia; Francesco Oddone; Cesare Mariotti; Silvio Di Staso; Luca Agnifili
Tags: blister, conjunctiva, diagnostic imaging, filtering surgery, glaucoma
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO114-BIO120. doi:https://doi.org/10.1167/iovs.17-21795
Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration Open Access
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Maximilian Pfau; Lukas Goerdt; Steffen Schmitz-Valckenberg; Matthias M. Mauschitz; Divyansh K. Mishra; Frank G. Holz; Moritz Lindner; Monika Fleckenstein
Tags: age-related macular degeneration, atrophy, autofluorescence, blue light, diagnostic imaging
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO121-BIO130. doi:https://doi.org/10.1167/iovs.17-21764
Biomarkers and Surrogate Endpoints in Uveitis: The Impact of Quantitative Imaging Open Access
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Alastair K. Denniston; Pearse A. Keane; Sunil K. Srivastava
Tags: biological markers, diagnostic imaging, surrogate endpoints, uveitis, inflammation
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO131-BIO140. doi:https://doi.org/10.1167/iovs.17-21788
Machine Learning of the Progression of Intermediate Age-Related Macular Degeneration Based on OCT Imaging Open Access
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Hrvoje Bogunović; Alessio Montuoro; Magdalena Baratsits; Maria G. Karantonis; Sebastian M. Waldstein; Ferdinand Schlanitz; Ursula Schmidt-Erfurth
Tags: age-related macular degeneration, diagnostic imaging, drusen, machine learning
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO141-BIO150. doi:https://doi.org/10.1167/iovs.17-21789
Oxidative Stress Measures of Lipid and DNA Damage in Human Tears Open Access
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Kristina M. Haworth; Heather L. Chandler
Tags: dna damage, linear regression, lipids, oxidative stress, enzyme-linked immunosorbent assay
Investigative Ophthalmology & Visual Science June 2017, Vol.58, BIO151-BIO157. doi:https://doi.org/10.1167/iovs.17-21436
Effective Dynamic Range and Retest Reliability of Dark-Adapted Two-Color Fundus-Controlled Perimetry in Patients With Macular Diseases Open Access
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Maximilian Pfau; Moritz Lindner; Philipp L. Müller; Johannes Birtel; Robert P. Finger; Wolf M. Harmening; Monika Fleckenstein; Frank G. Holz; Steffen Schmitz-Valckenberg
Tags: color, dynamic range, macular disorders, perimetry, reliability
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO158-BIO167. doi:https://doi.org/10.1167/iovs.17-21454
Evaluating Corneal Fluorescein Staining Using a Novel Automated Method Open Access
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Francisco Amparo; Haobing Wang; Jia Yin; Anna Marmalidou; Reza Dana
Tags: cornea, fluorescein stain method
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO168-BIO173. doi:https://doi.org/10.1167/iovs.17-21831
Iris Freckles a Potential Biomarker for Chronic Sun Damage Open Access
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Christoph Schwab; Christoph Mayer; Iris Zalaudek; Regina Riedl; Markus Richtig; Werner Wackernagel; Rainer Hofmann-Wellenhof; Georg Richtig; Gerald Langmann; Lisa Tarmann; Andreas Wedrich; Erika Richtig
Tags: freckles, immune reconstitution inflammatory syndrome, iris, photodamaged skin, sun exposure
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO174-BIO179. doi:https://doi.org/10.1167/iovs.17-21751
Detection of Functional Change Using Cluster Trend Analysis in Glaucoma Open Access
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Stuart K. Gardiner; Steven L. Mansberger; Shaban Demirel
Tags: cohort studies, eye, glaucoma, perimetry, specificity of diagnostic test
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO180-BIO190. doi:https://doi.org/10.1167/iovs.17-21562
Incidence and Factors Influencing Retinal Displacement in Eyes Treated for Rhegmatogenous Retinal Detachment With Vitrectomy and Gas or Silicone Oil Open Access
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Roberto dell'Omo; Andrea Scupola; Davide Viggiano; Maria Grazia Sammarco; Serena De Turris; Mario R. Romano; Gabriela Grimaldi; Ermanno dell'Omo; Ciro Costagliola
Tags: eye, incidence, radiation recall dermatitis, retina, rhegmatogenous retinal detachment
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO191-BIO199. doi:https://doi.org/10.1167/iovs.17-21466
Retinal Vessel Geometry and the Incidence and Progression of Diabetic Retinopathy Open Access
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Laurence S. Lim; Miao Li Chee; Carol Y. Cheung; Tien Yin Wong
Tags: diabetic retinopathy, incidence, retinal vessels, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, BIO200-BIO205. doi:https://doi.org/10.1167/iovs.17-21699
Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration Open Access
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José Cunha-Vaz; Luísa Ribeiro; Miguel Costa; Rafael Simó
Tags: diabetic retinopathy, longitudinal studies, macular edema, phenotype, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO206-BIO210. doi:https://doi.org/10.1167/iovs.17-21780
Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration Open Access
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Christine A. Curcio; Emma C. Zanzottera; Thomas Ach; Chandrakumar Balaratnasingam; K. Bailey Freund
Tags: age-related macular degeneration, atrophy, histology, spectral domain-optical coherence tomography, retinal pigment epithelium
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO211-BIO226. doi:https://doi.org/10.1167/iovs.17-21872
Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases Open Access
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Einar Stefánsson; Olof Birna Olafsdottir; Anna Bryndis Einarsdottir; Thorunn Scheving Eliasdottir; Thor Eysteinsson; Wouter Vehmeijer; Evelien Vandewalle; Toke Bek; Sveinn Hakon Hardarson
Tags: biological markers, brain diseases, oximetry, retinal diseases, diabetic retinopathy
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO227-BIO233. doi:https://doi.org/10.1167/iovs.17-21776
Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma Open Access
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David W. Sant; Wensi Tao; Matthew G. Field; Daniel Pelaez; Ke Jin; Anthony Capobianco; Sander R. Dubovy; David T. Tse; Gaofeng Wang
Tags: adenoid cystic carcinoma, mutation, whole exome sequencing, lacrimal gland
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO240-BIO246. doi:https://doi.org/10.1167/iovs.16-21097
Presence of Peripheral Neuropathy Is Associated With Progressive Thinning of Retinal Nerve Fiber Layer in Type 1 Diabetes Open Access
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Cirous Dehghani; Sangeetha Srinivasan; Katie Edwards; Nicola Pritchard; Anthony W. Russell; Rayaz A. Malik; Nathan Efron
Tags: diabetes mellitus, type 1, peripheral neuropathy, retinal nerve fiber layer, diabetes mellitus, type 2, diabetes mellitus
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO234-BIO239. doi:https://doi.org/10.1167/iovs.17-21801
Detection of Early Loss of Color Vision in Age-Related Macular Degeneration – With Emphasis on Drusen and Reticular Pseudodrusen Open Access
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Roopa Vemala; Sobha Sivaprasad; John L. Barbur
Tags: age-related macular degeneration, color vision, drusen, eye, pallor
Investigative Ophthalmology & Visual Science August 2017, Vol.58, BIO247-BIO254. doi:https://doi.org/10.1167/iovs.17-21771
Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging Open Access
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Katie M. Litts; Robert F. Cooper; Jacque L. Duncan; Joseph Carroll
Tags: biological markers, photoreceptors, retinal imaging, retinal cone, mosaicism
Investigative Ophthalmology & Visual Science September 2017, Vol.58, BIO255-BIO267. doi:https://doi.org/10.1167/iovs.17-21868
Metrics and Acquisition Modes for Fixation Stability as a Visual Function Biomarker Open Access
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Etienne M. Schönbach; Mohamed A. Ibrahim; Xiangrong Kong; Rupert W. Strauss; Beatriz Muñoz; David G. Birch; Janet S. Sunness; Sheila K. West; Hendrik P. N. Scholl
Tags: biological markers, stargardt's disease, vision, visual acuity, eye
Investigative Ophthalmology & Visual Science September 2017, Vol.58, BIO268-BIO276. doi:https://doi.org/10.1167/iovs.17-21710
Multidimensional Functional and Structural Evaluation Reveals Neuroretinal Impairment in Early Diabetic Retinopathy Open Access
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Katherine A. Joltikov; Vinicius M. de Castro; Jose R. Davila; Rohit Anand; Sami M. Khan; Neil Farbman; Gregory R. Jackson; Chris A. Johnson; Thomas W. Gardner
Tags: contrast sensitivity, diabetes mellitus, diabetic retinopathy, impairment, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science September 2017, Vol.58, BIO277-BIO290. doi:https://doi.org/10.1167/iovs.17-21863
Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2 Open Access
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Dibyendu Mukherjee; Eleonora M. Lad; Ryan R. Vann; Stephanie J. Jaffe; Traci E. Clemons; Martin Friedlander; Emily Y. Chew; Glenn J. Jaffe; Sina Farsiu; for the MacTel Study Group
Tags: diagnostic imaging, eye, optical coherence tomography, personal integrity, telangiectasis
Investigative Ophthalmology & Visual Science September 2017, Vol.58, BIO291-BIO299. doi:https://doi.org/10.1167/iovs.17-21834
The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy Open Access
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Rustum Karanjia; Adriana Berezovsky; Paula Yuri Sacai; Nivea Nunes Cavascan; Henry Yuheng Liu; Samir Nazarali; Milton Nunes Moraes-Filho; Kirsten Anderson; Jeffrey Show Tran; Sung EunSong Watanabe; Milton Nunes Moraes; Federico Sadun; Anna Maria DeNegri; Piero Barboni; Carolina do Val Ferreira Ramos; Chiara La Morgia; Valerio Carelli; Rubens Belfort, Jr; Stuart Glenn Coupland; Solange Rios Salomao; Alfredo A. Sadun
Tags: optic atrophy, hereditary, leber, retinal ganglion cells
Investigative Ophthalmology & Visual Science October 2017, Vol.58, BIO300-BIO306. doi:https://doi.org/10.1167/iovs.17-21773
Quantifying Microvascular Abnormalities With Increasing Severity of Diabetic Retinopathy Using Optical Coherence Tomography Angiography Open Access
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Peter L. Nesper; Philipp K. Roberts; Alex C. Onishi; Haitao Chai; Lei Liu; Lee M. Jampol; Amani A. Fawzi
Tags: angiogram, diabetic retinopathy, eye, optical coherence tomography, retina
Investigative Ophthalmology & Visual Science October 2017, Vol.58, BIO307-BIO315. doi:https://doi.org/10.1167/iovs.17-21787
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