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Research Highlight

Alternative Routes to Perfuse the Optic Nerve Head Open Access
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Richard H. W. Funk
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3575. doi:https://doi.org/10.1167/iovs.17-22492
Corneal Confocal Microscopy Is Emerging as a Powerful Diagnostic Tool for Assessing Systemic Neurologic Disease Open Access
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Nathan Efron
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3682. doi:https://doi.org/10.1167/iovs.17-22458

Anatomy and Pathology/Oncology

Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas Open Access
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Cassandra C. Skinner; James J. Augsburger; Bret D. Augsburger; Zelia M. Correa
Tags: neoplasms, tumor size, uveal melanoma, patient prognosis
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3335-3342. doi:https://doi.org/10.1167/iovs.16-20465

Clinical and Epidemiologic Research

Peripheral Design of Progressive Addition Lenses and the Lag of Accommodation in Myopes Open Access
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Tim Schilling; Arne Ohlendorf; Saulius R. Varnas; Siegfried Wahl
Tags: lens (device), lens, crystalline, papillon-lefevre disease, pediatric advanced life support, periarterial lymphatic sheath
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3319-3324. doi:https://doi.org/10.1167/iovs.17-21589
Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration Open Access
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Daniela Ferrara; Rachel E. Silver; Ricardo N. Louzada; Eduardo A. Novais; Giliann K. Collins; Johanna M. Seddon
Tags: age-related macular degeneration, optical coherence tomography, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3519-3529. doi:https://doi.org/10.1167/iovs.17-21696
Association Between Visual Function Response and Reduction of Inflammation in Noninfectious Uveitis of the Posterior Segment Open Access
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Benedicte Lescrauwaet; Elisabetta Miserocchi; Stephan Thurau; Bahram Bodaghi; Luc Duchateau; Thomas Verstraeten; Sunil Srivastava
Tags: inflammation, uveitis, vision
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3555-3562. doi:https://doi.org/10.1167/iovs.17-22049
Correlations Between Macular, Skin, and Serum Carotenoids Open Access
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Christopher D. Conrady; James P. Bell; Brian M. Besch; Aruna Gorusupudi; Kelliann Farnsworth; Igor Ermakov; Mohsen Sharifzadeh; Maia Ermakova; Werner Gellermann; Paul S. Bernstein
Tags: carotenoids, skin
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3616-3627. doi:https://doi.org/10.1167/iovs.17-21818
Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes Open Access
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Henry Shen-Lih Chen; Chun-Hsiu Liu; Wei-Chi Wu; Hsiao-Jung Tseng; Yung-Sung Lee
Tags: angiogram, eye, glaucoma, open-angle glaucoma, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3637-3645. doi:https://doi.org/10.1167/iovs.17-21846
A Global View on Output and Outcomes of Cataract Surgery With National Indices of Socioeconomic Development Open Access
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Wei Wang; William Yan; Andreas Müller; Mingguang He
Tags: cataract, cataract surgery, socioeconomic factors, surgical procedures, operative, blindness
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3669-3676. doi:https://doi.org/10.1167/iovs.17-21489

Cornea

The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells Open Access
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Akane Hongo; Naoki Okumura; Makiko Nakahara; EunDuck P. Kay; Noriko Koizumi
Tags: cellular senescence, cornea, mitogen-activated protein kinase p38, mitogen-activated protein kinase inhibitors, endothelial cells
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3325-3334. doi:https://doi.org/10.1167/iovs.16-21170
Silk Fibroin Films for Corneal Endothelial Regeneration: Transplant in a Rabbit Descemet Membrane Endothelial Keratoplasty Open Access
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Natalia Vázquez; Carlos A. Rodríguez-Barrientos; Salvador D. Aznar-Cervantes; Manuel Chacón; José L. Cenis; Ana C. Riestra; Ronald M. Sánchez-Avila; Mairobi Persinal; Agustín Brea-Pastor; Luis Fernández-Vega Cueto; Álvaro Meana; Jesús Merayo-Lloves
Tags: chronic exertional compartment syndrome, cornea, endothelium, fibroins, keratoplasty
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3357-3365. doi:https://doi.org/10.1167/iovs.17-21797
An Anti–VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea Open Access
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Yazad D. Irani; Pierre D. Scotney; Sonja Klebe; Lauren A. Mortimer; Andrew D. Nash; Keryn A. Williams
Tags: cornea, vascular endothelial growth factor b
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 3404-3413. doi:https://doi.org/10.1167/iovs.16-21343
Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study Open Access
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Patricia Gallego-Muñoz; Lucía Ibares-Frías; Elvira Lorenzo; Susana Marcos; Pablo Peréz-Merino; Nandor Bekesi; Irene E. Kochevar; M. Carmen Martínez-García
Tags: cornea, rose bengal, wound healing, epithelium
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3471-3480. doi:https://doi.org/10.1167/iovs.16-21365
TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus Open Access
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Muneeza Arbab; Saira Tahir; Muhammad Khizar Niazi; Mazhar Ishaq; Alamdar Hussain; Pir Muhammad Siddique; Sadia Saeed; Wajid Ali Khan; Raheel Qamar; Azeem Mehmood Butt; Maleeha Azam
Tags: genetic predisposition to disease, keratoconus, tumor necrosis factors
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3481-3487. doi:https://doi.org/10.1167/iovs.16-21400
Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns Open Access
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Romain Joubert; Estelle Daniel; Nicolas Bonnin; Aurélie Comptour; Christelle Gross; Corinne Belville; Frédéric Chiambaretta; Loïc Blanchon; Vincent Sapin
Tags: alkalies, amnion, burns, cornea, tissue transplants
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3513-3518. doi:https://doi.org/10.1167/iovs.17-21810
Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in Multiple Sclerosis Open Access
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Ioannis N. Petropoulos; Saadat Kamran; Yi Li; Adnan Khan; Georgios Ponirakis; Naveed Akhtar; Dirk Deleu; Ashfaq Shuaib; Rayaz A. Malik
Tags: cornea, diagnostic imaging, microscopy, confocal, multiple sclerosis, retrograde degeneration
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3677-3681. doi:https://doi.org/10.1167/iovs.17-22050
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy Open Access
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Naoki Okumura; Miu Kitahara; Hirokazu Okuda; Keisuke Hashimoto; Emi Ueda; Makiko Nakahara; Shigeru Kinoshita; Robert D. Young; Andrew J. Quantock; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
Tags: cell death, cornea, corneal endothelium, endothelium, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3697-3707. doi:https://doi.org/10.1167/iovs.16-21023
Monocarboxylate Transporters Mediate Fluorescein Uptake in Corneal Epithelial Cells Open Access
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Yi-Chen Sun; Hau-Min Liou; Po-Ting Yeh; Wei-Li Chen; Fung-Rong Hu
Tags: fluorescein, membrane transport proteins, oryctolagus cuniculus, corneal epithelial cells
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3716-3722. doi:https://doi.org/10.1167/iovs.16-20998
Conditionally Immortal Slc4a11−/− Mouse Corneal Endothelial Cell Line Recapitulates Disrupted Glutaminolysis Seen in Slc4a11−/− Mouse Model Open Access
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Wenlin Zhang; Diego G. Ogando; Edward T. Kim; Moon-Jung Choi; Hongde Li; Jason M. Tenessen; Joseph A. Bonanno
Tags: cornea, endothelial cells, mice, viral tumor antigens
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3723-3731. doi:https://doi.org/10.1167/iovs.17-21781

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy Open Access
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Chun-Hsiu Liu; Wei-Chi Wu; Ming-Hui Sun; Ling-Yuh Kao; Yung-Sung Lee; Henry Shen-Lih Chen
Tags: open-angle glaucoma, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3350-3356. doi:https://doi.org/10.1167/iovs.17-22021
Impact of Amyotrophic Lateral Sclerosis on Slow Tonic Myofiber Composition in Human Extraocular Muscles Open Access
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Anton E. Tjust; Adam Danielsson; Peter M. Andersen; Thomas Brännström; Fatima Pedrosa Domellöf
Tags: amyotrophic lateral sclerosis, muscle of orbit, muscle, antibodies
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3708-3715. doi:https://doi.org/10.1167/iovs.17-22098

Genetics

Screening of BEST1 Gene in a Chinese Cohort With Best Vitelliform Macular Dystrophy or Autosomal Recessive Bestrophinopathy Open Access
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Lu Tian; Tengyang Sun; Ke Xu; Xiaohui Zhang; Xiaoyan Peng; Yang Li
Tags: autosomal recessive inheritance, chinese people, cohort studies, genes, mutation
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3366-3375. doi:https://doi.org/10.1167/iovs.17-21999
Frequent GNAQ, GNA11, and EIF1AX Mutations in Iris Melanoma Open Access
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Simone L. Scholz; Inga Möller; Henning Reis; Daniela Süßkind; Johannes A. P. van de Nes; Sonia Leonardelli; Bastian Schilling; Elisabeth Livingstone; Tobias Schimming; Annette Paschen; Antje Sucker; Rajmohan Murali; Klaus-Peter Steuhl; Dirk Schadendorf; Henrike Westekemper; Klaus G. Griewank
Tags: malignant melanoma of iris, mutation, neoplasms, bap1 gene
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3464-3470. doi:https://doi.org/10.1167/iovs.17-21838
Caucasian Families Exhibit Significant Linkage of Myopia to Chromosome 11p Open Access
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Anthony M. Musolf; Claire L. Simpson; Bilal A. Moiz; Kyle A. Long; Laura Portas; Federico Murgia; Elise B. Ciner; Dwight Stambolian; Joan E. Bailey-Wilson
Tags: chromosomes, european continental ancestry group, family, myopia, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3547-3554. doi:https://doi.org/10.1167/iovs.16-21271
Effects of Pathogenic Variations in the Human Rhodopsin Gene (hRHO) on the Predicted Accessibility for a Lead Candidate Ribozyme Open Access
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Beau R. Froebel; Alexandria J. Trujillo; Jack M. Sullivan
Tags: catalytic rna, genes, mutation, nucleotides, rhodopsin
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3576-3591. doi:https://doi.org/10.1167/iovs.16-20877

Glaucoma

Wayfinding and Glaucoma: A Virtual Reality Experiment Open Access
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Fábio B. Daga; Eduardo Macagno; Cory Stevenson; Ahmed Elhosseiny; Alberto Diniz-Filho; Erwin R. Boer; Jürgen Schulze; Felipe A. Medeiros
Tags: glaucoma, virtual reality
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3343-3349. doi:https://doi.org/10.1167/iovs.17-21849
Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers Open Access
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Ning-Jiun Jan; Celeste Gomez; Saundria Moed; Andrew P. Voorhees; Joel S. Schuman; Richard A. Bilonick; Ian A. Sigal
Tags: collagen, sclera
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3378-3388. doi:https://doi.org/10.1167/iovs.17-21811
An Ilomastat-CD Eye Drop Formulation to Treat Ocular Scarring Open Access
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Abeer H. A. Mohamed-Ahmed; Alastair Lockwood; He Li; Maryse Bailly; Peng T. Khaw; Steve Brocchini
Tags: cicatrix, eyedrops, solubility, water, painful bladder syndrome
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3425-3431. doi:https://doi.org/10.1167/iovs.16-21377
Inhibition of Monocyte Chemoattractant Protein 1 Prevents Conjunctival Fibrosis in an Experimental Model of Glaucoma Filtration Surgery Open Access
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Rachel Shujuan Chong; Ying Shi Lee; Stephanie Wai Ling Chu; Li Zhen Toh; Tina Tzee Ling Wong
Tags: blister, conjunctiva, fibrosis, filtering surgery, glaucoma
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3432-3439. doi:https://doi.org/10.1167/iovs.17-21480
Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position Open Access
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Christopher A. Girkin; Massimo A. Fazio; Hongli Yang; Juan Reynaud; Claude F. Burgoyne; Brandon Smith; Lan Wang; J. Crawford Downs
Tags: continental population groups, cribriform plate, donors, eye, optic disk
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3759-3769. doi:https://doi.org/10.1167/iovs.17-21842

Immunology and Microbiology

B Cell Anomalies in Autoimmune Retinopathy (AIR) Open Access
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Elena Stansky; Angélique Biancotto; Pradeep K. Dagur; Sapna Gangaputra; Benjamin Chaigne-Delalande; Robert B. Nussenblatt; H. Nida Sen; J. Philip McCoy, Jr
Tags: autoimmunity, b-lymphocytes, retinal diseases, cytokine, memory
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3600-3607. doi:https://doi.org/10.1167/iovs.17-21704

Lens

Switching of α-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation Open Access
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Rupalatha Maddala; Ponugoti Vasantha Rao
Tags: lens (device), lens, crystalline, mice, epithelium, proteins
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3445-3455. doi:https://doi.org/10.1167/iovs.17-21539
Iris-Claw Intraocular Lens and Scleral-Fixated Posterior Chamber Intraocular Lens Implantations in Correcting Aphakia: A Meta-Analysis Open Access
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Wu Jing; Liang Guanlu; Zheng Qianyin; Li Shuyi; He Fengying; Liu Jian; Xu Wen
Tags: aphakia, immune reconstitution inflammatory syndrome, implantation procedure, intraocular lens implant device, intraocular lens implantation procedure
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3530-3536. doi:https://doi.org/10.1167/iovs.16-21226

Low Vision

Blur Adaptation to Central Retinal Disease Open Access
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Fuensanta A. Vera-Diaz; Russell L. Woods; Eli Peli
Tags: perception, retinal diseases, vision
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3646-3655. doi:https://doi.org/10.1167/iovs.16-20849

Retina

Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule Open Access
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Kyoko Ohno-Matsui; Yuxin Fang; Kei Morohoshi; Jost B. Jonas
Tags: diagnostic imaging, episcleral fascia, eye, optical coherence tomography, sclera
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3389-3394. doi:https://doi.org/10.1167/iovs.16-21394
Analysis of Retinal Architectural Changes Using Intraoperative OCT Following Surgical Manipulations With Membrane Flex Loop in the DISCOVER Study Open Access
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Atsuro Uchida; Sunil K. Srivastava; Justis P. Ehlers
Tags: intraoperative care, surgical procedures, operative, tissue membrane
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3440-3444. doi:https://doi.org/10.1167/iovs.17-21584
Prevalence and Risk Factors for Nonexudative Neovascularization in Fellow Eyes of Patients With Unilateral Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Open Access
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Yasuo Yanagi; Aditi Mohla; Won-Ki Lee; Shu Yen Lee; Ranjana Mathur; Choi Mun Chan; Ian Yeo; Tien Yin Wong; Chui Ming Gemmy Cheung
Tags: age-related macular degeneration, choroidal neovascularization, eye, neovascularization, pathologic, prevalence
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3488-3495. doi:https://doi.org/10.1167/iovs.16-21167
Reduced Retinal Vessel Density in Obstructive Sleep Apnea Syndrome Patients: An Optical Coherence Tomography Angiography Study Open Access
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Jian Yu; Kuanlin Xiao; Jingjing Huang; Xinghuai Sun; Chunhui Jiang
Tags: angiogram, obstructive sleep apnea, optical coherence tomography, retinal vessels
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3506-3512. doi:https://doi.org/10.1167/iovs.17-21414
A Quantitative and Qualitative Exploration of Photoaversion in Achromatopsia Open Access
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Jonathan Aboshiha; Neruban Kumaran; Angelos Kalitzeos; Chris Hogg; Gary Rubin; Michel Michaelides
Tags: achromatopsia, eyelid, lighting, photophobia, surveys
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3537-3546. doi:https://doi.org/10.1167/iovs.17-21935
Inter-Relationship of Arterial Supply to Human Retina, Choroid, and Optic Nerve Head Using Micro Perfusion and Labeling Open Access
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Paula K. Yu; Ian L. McAllister; William H. Morgan; Stephen J. Cringle; Dao-Yi Yu
Tags: blood supply, arterial, choroid, eye, microbiology procedures, optic disk
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3565-3574. doi:https://doi.org/10.1167/iovs.17-22191
Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy Open Access
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Preena Tanna; Melissa Kasilian; Rupert Strauss; James Tee; Angelos Kalitzeos; Sergey Tarima; Alexis Visotcky; Alfredo Dubra; Joseph Carroll; Michel Michaelides
Tags: reliability, retinal cone, retinal diseases, stargardt's disease, mosaicism
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3608-3615. doi:https://doi.org/10.1167/iovs.17-21904
Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats Open Access
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Ruiping Gu; Wenyi Tang; Boya Lei; Xinyi Ding; Cheng Jiang; Gezhi Xu
Tags: bcl-xl protein, glucocorticoids, leucine zippers, light exposure, opportunity for error
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3656-3668. doi:https://doi.org/10.1167/iovs.17-22116
OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From the AVATAR Study Open Access
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Anne P. Runkle; Peter K. Kaiser; Sunil K. Srivastava; Andrew P. Schachat; Jamie L. Reese; Justis P. Ehlers
Tags: angiogram, telangiectasis, blood capillaries, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3683-3689. doi:https://doi.org/10.1167/iovs.16-20976
Indocyanine Green Angiography and Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration Open Access
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Chiara M. Eandi; Antonio Ciardella; Mariacristina Parravano; Filippo Missiroli; Camilla Alovisi; Chiara Veronese; Maria C. Morara; Massimo Grossi; Gianni Virgili; Federico Ricci
Tags: choroidal neovascularization, angiogram, exudative age-related macular degeneration, indocyanine green angiography, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3690-3696. doi:https://doi.org/10.1167/iovs.17-21941
A Pharmacodynamic Analysis of Choroidal Neovascularization in a Porcine Model Using Three Targeted Drugs Open Access
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Jeffrey Tran; Caroline Craven; Kathy Wabner; Jenn Schmit; Brock Matter; Uday Kompella; Hans E. Grossniklaus; Timothy W. Olsen
Tags: choroidal neovascularization, surgical procedures, operative, pazopanib, suidae
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3732-3740. doi:https://doi.org/10.1167/iovs.16-21230
Posterior Staphylomas in Pathologic Myopia Imaged by Widefield Optical Coherence Tomography Open Access
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Kosei Shinohara; Noriaki Shimada; Muka Moriyama; Takeshi Yoshida; Jost B. Jonas; Nagahisa Yoshimura; Kyoko Ohno-Matsui
Tags: 3d mri, myopic macular degeneration, optical coherence tomography, staphyloma, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3750-3758. doi:https://doi.org/10.1167/iovs.17-22319
Macular Vascular Fractal Dimension in the Deep Capillary Layer as an Early Indicator of Microvascular Loss for Retinopathy in Type 2 Diabetic Patients Open Access
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Qi Chen; Qingkai Ma; Chaoming Wu; Fan Tan; Feng Chen; Qiuyan Wu; Rong Zhou; Xiran Zhuang; Fan Lu; Jia Qu; Meixiao Shen
Tags: blood capillaries, diabetes mellitus, fractals, retinal diseases
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3785-3794. doi:https://doi.org/10.1167/iovs.17-21461
Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure Open Access
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Yantao Wei; Hong Jiang; Yingying Shi; Dongyi Qu; Giovanni Gregori; Fang Zheng; Tatjana Rundek; Jianhua Wang
Tags: aging, microcirculation, retina, retinal vasculature, retinal vessels
Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3804-3817. doi:https://doi.org/10.1167/iovs.17-21460
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO) Open Access
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Md. Imam Uddin; Ashwath Jayagopal; Gary W. McCollum; Rong Yang; John S. Penn
Tags: diagnostic imaging, hypoxia, mice, retinal vein occlusion, fluorescence
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3818-3824. doi:https://doi.org/10.1167/iovs.16-21187

Retinal Cell Biology

Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging Open Access
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Andrew W. Browne; Cosimo Arnesano; Narine Harutyunyan; Thien Khuu; Juan Carlos Martinez; Harvey A. Pollack; David S. Koos; Thomas C. Lee; Scott E. Fraser; Rex A. Moats; Jennifer G. Aparicio; David Cobrinik
Tags: diagnostic imaging, organoids
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3311-3318. doi:https://doi.org/10.1167/iovs.16-20796
TNFα-Induced Disruption of the Blood–Retinal Barrier In Vitro Is Regulated by Intracellular 3′,5′-Cyclic Adenosine Monophosphate Levels Open Access
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Anne-Eva van der Wijk; Ilse M. C. Vogels; Cornelis J. F. van Noorden; Ingeborg Klaassen; Reinier O. Schlingemann
Tags: cyclic amp, permeability, adenosine monophosphate, blood-retinal barrier
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3496-3505. doi:https://doi.org/10.1167/iovs.16-21091
Apatinib, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Suppresses Pathologic Ocular Neovascularization in Mice Open Access
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Koung Li Kim; Wonhee Suh
Tags: apatinib, choroidal neovascularization, mice, neovascularization, pathologic, vascular endothelial growth factor receptor-2
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3592-3599. doi:https://doi.org/10.1167/iovs.17-21416
Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency Open Access
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Saumya Nagar; Dorit Trudler; Scott R. McKercher; Juan Piña-Crespo; Nobuki Nakanishi; Shu-Ichi Okamoto; Stuart A. Lipton
Tags: mef2 transcription factors, photoreceptors, tissue degeneration, mice, retina
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3741-3749. doi:https://doi.org/10.1167/iovs.17-21767
BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal Open Access
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Hiroyuki Sakagami; Osamu Katsumata; Yoshinobu Hara; Toshikuni Sasaoka; Masahiro Fukaya
Tags: antibodies, dystrophin, guanine nucleotide exchange factors, mice, photoreceptors
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3795-3803. doi:https://doi.org/10.1167/iovs.17-21746

Visual Neuroscience

Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina Open Access
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Kerry J. Halupka; Carla J. Abbott; Yan T. Wong; Shaun L. Cloherty; David B. Grayden; Anthony N. Burkitt; Evgeni N. Sergeev; Chi D. Luu; Alice Brandli; Penelope J. Allen; Hamish Meffin; Mohit N. Shivdasani
Tags: eye, retina, retinal degeneration
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3770-3784. doi:https://doi.org/10.1167/iovs.16-21290

Visual Psychophysics and Physiological Optics

Alterations to the Foveal Cone Mosaic of Diabetic Patients Open Access
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Lucie Sawides; Kaitlyn A. Sapoznik; Alberto de Castro; Brittany R. Walker; Thomas J. Gast; Ann E. Elsner; Stephen A. Burns
Tags: diabetes mellitus, mosaicism, retinal cone, diagnostic imaging
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3395-3403. doi:https://doi.org/10.1167/iovs.17-21793
Spatial Entropy Pursuit for Fast and Accurate Perimetry Testing Open Access
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Derk Wild; Şerife Seda Kucur; Raphael Sznitman
Tags: entropy, glaucoma, perimetry, visual fields
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 3414-3424. doi:https://doi.org/10.1167/iovs.16-21144
A Normative Data Set for the Clinical Assessment of Achromatic and Chromatic Contrast Sensitivity Using a qCSF Approach Open Access
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Yeon Jin Kim; Alexandre Reynaud; Robert F. Hess; Kathy T. Mullen
Tags: acetylcholine, achondroplasia, contrast sensitivity, datasets, spatial frequency
Investigative Ophthalmology & Visual Science March 2018, Vol.58, 3628-3636. doi:https://doi.org/10.1167/iovs.17-21645

Research Opportunities

Report From the NEI/FDA Endpoints Workshop on Age-Related Macular Degeneration and Inherited Retinal Diseases Open Access
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Karl Csaky; Frederick Ferris, III; Emily Y. Chew; Prashant Nair; Janet K. Cheetham; Jacque L. Duncan
Tags: retinal diseases, surrogate endpoints, united states food and drug administration, age-related macular degeneration, eye
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3456-3463. doi:https://doi.org/10.1167/iovs.17-22339

Letters to the Editor

Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes Open Access
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Gema Rebolleda; Laura Díez-Álvarez; Victoria de Juan; Francisco J. Muñoz-Negrete
Tags: cribriform plate, eye, glaucoma, intraocular pressure, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3376. doi:https://doi.org/10.1167/iovs.17-22262
Author Response: Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes Open Access
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Harry A. Quigley
Tags: cribriform plate, eye, glaucoma, intraocular pressure, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3377. doi:https://doi.org/10.1167/iovs.17-22317
Choriocapillaris Flow in Myopia Open Access
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Richard F. Spaide
Tags: myopia
Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3563-3564. doi:https://doi.org/10.1167/iovs.17-22042

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science July 2017, Vol.58, 3825. doi:https://doi.org/10.1167/iovs.16-20361a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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