Volume 58 Issue 10 | IOVS

Research Highlight

Birdshot Chorioretinitis and Fundus Autofluorescence: Novel Insights Into Disease Pathogenesis Open Access

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Steven Yeh

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4026. doi:https://doi.org/10.1167/iovs.17-22580

The Riddle of Intermittent Exotropia Open Access

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Michael C. Brodsky

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4056. doi:https://doi.org/10.1167/iovs.17-22644

Anatomy and Pathology/Oncology

PRiMeUM: A Model for Predicting Risk of Metastasis in Uveal Melanoma Open Access

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Jorge Vaquero-Garcia; Emilie Lalonde; Kathryn G. Ewens; Jessica Ebrahimzadeh; Jennifer Richard-Yutz; Carol L. Shields; Alejandro Barrera; Christopher J. Green; Yoseph Barash; Arupa Ganguly

Tags: neoplasm metastasis, neoplasms, uveal melanoma, chromosomes

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4096-4105. doi:https://doi.org/10.1167/iovs.17-22255

Clinical and Epidemiologic Research

Uvemaster: A Mobile App-Based Decision Support System for the Differential Diagnosis of Uveitis Open Access

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Jose A. Gegundez-Fernandez; Jose I. Fernandez-Vigo; David Diaz-Valle; Rosalia Mendez-Fernandez; Ricardo Cuiña-Sardiña; Enrique Santos-Bueso; Jose M. Benitez-del-Castillo

Tags: differential diagnosis, uveitis, decision support systems, syndrome

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3931-3939. doi:https://doi.org/10.1167/iovs.17-21493

Variations and Trends in Health Burden of Visual Impairment Due to Cataract: A Global Analysis Open Access

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Miao He; Wei Wang; Wenyong Huang

Tags: blindness, cataract, health, visual impairment, trend

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4299-4306. doi:https://doi.org/10.1167/iovs.17-21459

Subclinical Decrease in Central Inner Retinal Activity Is Associated With Myopia Development in Children Open Access

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Serena Zhe-Chuang Li; Wing-Yan Yu; Kai-Yip Choi; Christie Hang-I Lam; Yamunadevi Lakshmanan; Francisca Siu-Yin Wong; Henry Ho-Lung Chan

Tags: child development, myopia, refractive errors, child

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4399-4406. doi:https://doi.org/10.1167/iovs.16-21279

Cornea

Chondroitin Sulfate–Based Biocompatible Crosslinker Restores Corneal Mechanics and Collagen Alignment Open Access

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Xiaokun Wang; Shoumyo Majumdar; Garret Ma; Jeeyeon Sohn; Samuel C. Yiu; Walter Stark; Awad Al-Qarni; Deepak P. Edward; Jennifer H. Elisseeff

Tags: collagen, cornea, national health service (uk), chondroitin sulfates, corneal collagen cross-linking

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3887-3895. doi:https://doi.org/10.1167/iovs.16-21292

Long-Term Biomechanical and Histologic Results of WST-D/NIR Corneal Stiffening in Rabbits, Up to 8 Months Follow-up Open Access

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Jurriaan Brekelmans; Alexandra Goz; Mor M. Dickman; Alexander Brandis; Xiaomeng Sui; H. Daniel Wagner; Rudy M. M. A. Nuijts; Avigdor Scherz; Arie L. Marcovich

Tags: cornea, follow-up, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4089-4095. doi:https://doi.org/10.1167/iovs.17-22108

Allogeneic Descemet's Membrane Transplantation Enhances Corneal Endothelial Monolayer Formation and Restores Functional Integrity Following Descemet's Stripping Open Access

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Maninder Bhogal; Chan N. Lwin; Xin-Yi Seah; Gary Peh; Jodhbir S. Mehta

Tags: cornea, descemet's membrane, endothelial cells, endothelium, transplantation

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4249-4260. doi:https://doi.org/10.1167/iovs.17-22106

Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis Open Access

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Anna R. Blanco; Antonia Nostro; Valeria D'Angelo; Manuela D'Arrigo; Maria G. Mazzone; Andreana Marino

Tags: antibiotic therapy, candida albicans, chloramphenicol, colistimethate, fungal keratitis

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4292-4298. doi:https://doi.org/10.1167/iovs.17-22047

Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6–Dependent Stem Cell Activation and Macrophage Switch Open Access

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Guohu Di; Xianli Du; Xia Qi; Xiaowen Zhao; Haoyun Duan; Suxia Li; Lixin Xie; Qingjun Zhou

Tags: cornea, diabetes mellitus, epithelium, wound healing, stem cells

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4344-4354. doi:https://doi.org/10.1167/iovs.17-21506

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Incomitance and Eye Dominance in Intermittent Exotropia Open Access

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Daniel L. Adams; John R. Economides; Jonathan C. Horton

Tags: exotropia, eye, intermittent exotropia, ocular dominance

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4049-4055. doi:https://doi.org/10.1167/iovs.17-22155

Predictors of Sensitivity to Perceptual Learning in Children With Infantile Nystagmus Open Access

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Bianca Huurneman; F. Nienke Boonstra; Jeroen Goossens

Tags: child, pathologic nystagmus, perceptual learning, training, happiness

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4162-4172. doi:https://doi.org/10.1167/iovs.17-21913

Does Decreased Static Ocular Counter Rolling Account for Bielschowsky Head Tilt Test in Unilateral Superior Oblique Palsy? Open Access

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Da Ye Diana Choi; Soo Min Lee; Kyung Ah Park; Sei Yeul Oh

Tags: bielschowsky head tilt test, eye, fourth cranial nerve palsy, hypertropia, musculoskeletal torsion, function

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4268-4273. doi:https://doi.org/10.1167/iovs.17-22166

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations Open Access

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Mark J. Kupersmith; Patrick A. Sibony; Sarita Dave

Tags: nonarteritic anterior ischemic optic neuropathy, eye, edema, optic disk, papilledema

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4286-4291. doi:https://doi.org/10.1167/iovs.17-22140

Dynamic Imaging of the Eye, Optic Nerve, and Extraocular Muscles With Golden Angle Radial MRI Open Access

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Saikat Sengupta; David S. Smith; Alex K. Smith; E. Brian Welch; Seth A. Smith

Tags: diagnostic imaging, eye, magnetic resonance imaging, muscle of orbit, optic nerve

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4390-4398. doi:https://doi.org/10.1167/iovs.17-21861

Genetics

C2orf71 Mutations as a Frequent Cause of Autosomal-Recessive Retinitis Pigmentosa: Clinical Analysis and Presentation of 8 Novel Mutations Open Access

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Christina Gerth-Kahlert; Amit Tiwari; James V. M. Hanson; Vaishnavi Batmanabane; Elias Traboulsi; Mark E. Pennesi; Abdullah A. Al-Qahtani; Byron L. Lam; John Heckenlively; Sandrine A. Zweifel; Ajoy Vincent; Fabienne Fierz; Daniel Barthelmes; Kari Branham; Naheed Khan; Angela Bahr; Luzy Baehr; István Magyar; Samuel Koller; Silvia Azzarello-Burri; Dunja Niedrist; Elise Heon; Wolfgang Berger

Tags: autosomal recessive inheritance, de novo mutation, genes, mutation, phenotype

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3840-3850. doi:https://doi.org/10.1167/iovs.17-21597

Choroidal Vasculature in Bietti Crystalline Dystrophy With CYP4V2 Mutations and in Retinitis Pigmentosa With EYS Mutations Open Access

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Takako Hirashima; Manabu Miyata; Kenji Ishihara; Tomoko Hasegawa; Masako Sugahara; Ken Ogino; Munemitsu Yoshikawa; Masayuki Hata; Yoshimasa Kuroda; Yuki Muraoka; Sotaro Ooto; Nagahisa Yoshimura

Tags: crystal structure, mutation, retinitis pigmentosa, vasculature

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3871-3878. doi:https://doi.org/10.1167/iovs.17-21515

Leber's Hereditary Optic Neuropathy–Specific Mutation m.11778G>A Exists on Diverse Mitochondrial Haplogroups in India Open Access

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Nahid Akhtar Khan; Periyasamy Govindaraj; Nagasamy Soumittra; Sonika Sharma; Sundaramoorthy Srilekha; Selvakumar Ambika; Ayyasamy Vanniarajan; Angamuthu Kanikannan Meena; Megha S. Uppin; Challa Sundaram; Parayil Sankaran Bindu; Narayanappa Gayathri; Arun B. Taly; Kumarasamy Thangaraj

Tags: dna, mitochondrial, mitochondria, mutation, optic atrophy, hereditary, leber, india

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3923-3930. doi:https://doi.org/10.1167/iovs.16-20695

Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1 Open Access

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Patrice J. Persad; Iris M. Heid; Daniel E. Weeks; Paul N. Baird; Eiko K. de Jong; Jonathan L. Haines; Margaret A. Pericak-Vance; William K. Scott; for the International Age-Related Macular Degeneration Genomics Consortium (IAMDGC)

Tags: age-related macular degeneration, datasets, genome, mitochondria, significance

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4027-4038. doi:https://doi.org/10.1167/iovs.17-21734

A Novel Potentially Causative Variant of NDUFAF7 Revealed by Mutation Screening in a Chinese Family With Pathologic Myopia Open Access

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Baojiang Wang; Yongli Liu; Shiguo Chen; Yunmiao Wu; Sheng Lin; Yongheng Duan; Kaifeng Zheng; Linghua Zhang; Xueying Gu; Wenxu Hong; Hao Shao; Xuchun Zeng; Bi Sun; Shan Duan

Tags: family, mutation, myopic macular degeneration, screening, chinese (other dialects)

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4182-4192. doi:https://doi.org/10.1167/iovs.16-20941

Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese Open Access

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Jing Deng; Jiayue Hu; Handan Tan; Guannan Su; Qingfeng Cao; Xinyue Huang; Aize Kijlstra; Peizeng Yang

Tags: chinese (other dialects), chinese people, genotype, ophthalmia, sympathetic, polymorphism

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4218-4222. doi:https://doi.org/10.1167/iovs.17-22195

Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese Open Access

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Fang Yao Tang; Li Ma; Pancy O. S. Tam; Chi Pui Pang; Clement C. Tham; Li Jia Chen

Tags: angle closure glaucoma, chinese (other dialects), chinese people, genetics, single nucleotide polymorphism

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4384-4389. doi:https://doi.org/10.1167/iovs.17-22304

Glaucoma

Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins Open Access

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Liwei Zhang; Guangyu Li; Meng Shi; Hsin-Hua Liu; Shaokui Ge; Yvonne Ou; John G. Flanagan; Lu Chen

Tags: intraocular pressure, laser therapy, lasers, mice, ocular hypertension

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3879-3886. doi:https://doi.org/10.1167/iovs.16-20807

Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma Open Access

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Zhihui Guo; Young H. Kwon; Kyungmoo Lee; Kai Wang; Andreas Wahle; Wallace L. M. Alward; John H. Fingert; Daniel I. Bettis; Chris A. Johnson; Mona K. Garvin; Milan Sonka; Michael D. Abràmoff

Tags: glaucoma, optical coherence tomography, visual fields

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3975-3985. doi:https://doi.org/10.1167/iovs.17-21832

Conjunctival Bacteria Flora of Glaucoma Patients During Long-Term Administration of Prostaglandin Analog Drops Open Access

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Shinichiro Ohtani; Kimiya Shimizu; Ryohei Nejima; Fumie Kagaya; Makoto Aihara; Takuya Iwasaki; Nobuyuki Shoji; Kazunori Miyata

Tags: bacteria, conjunctiva, glaucoma, prostaglandins, synthetic, disease susceptibility

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3991-3996. doi:https://doi.org/10.1167/iovs.16-20853

Effects of Vitrectomy and Lensectomy on Older Rhesus Macaques: Oxygen Distribution, Antioxidant Status, and Aqueous Humor Dynamics Open Access

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Carla J. Siegfried; Ying-Bo Shui; Baohe Tian; T. Michael Nork; Gregg A. Heatley; Paul L. Kaufman

Tags: antioxidants, aqueous humor, macaca, macaca mulatta, oxygen

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4003-4014. doi:https://doi.org/10.1167/iovs.17-21890

Oxidative Stress–Related Molecular Biomarker Candidates for Glaucoma Open Access

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Gözde Hondur; Emre Göktaş; Xiangjun Yang; Lama Al-Aswad; James D. Auran; Dana M. Blumberg; George A. Cioffi; Jeffrey M. Liebmann; Leejee H. Suh; Danielle Trief; Gülgün Tezel

Tags: biological markers, glaucoma, oxidative stress, proteins

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4078-4088. doi:https://doi.org/10.1167/iovs.17-22242

Determinants and Characteristics of Bruch's Membrane Opening and Bruch's Membrane Opening–Minimum Rim Width in a Normal Japanese Population Open Access

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Makoto Araie; Aiko Iwase; Kazuhisa Sugiyama; Toru Nakazawa; Goji Tomita; Masanori Hangai; Yasuo Yanagi; Hiroshi Murata; Hidenobu Tanihara; Claude F. Burgoyne; Balwantray C. Chauhan

Tags: bruch's basal membrane, japanese, optic disk, eye, glaucoma

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4106-4113. doi:https://doi.org/10.1167/iovs.17-22057

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure Open Access

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Joseph L. Demer; Robert A. Clark; Soh Youn Suh; JoAnn A. Giaconi; Kouros Nouri-Mahdavi; Simon K. Law; Laura Bonelli; Anne L. Coleman; Joseph Caprioli

Tags: adduction, eye, glaucoma, intraocular pressure, magnetic resonance imaging

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4114-4125. doi:https://doi.org/10.1167/iovs.17-22093

Racial Differences in the Extracellular Matrix and Histone Acetylation of the Lamina Cribrosa and Peripapillary Sclera Open Access

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Hae-Young Lopilly Park; Jie Hyun Kim; Younhea Jung; Chan Kee Park

Tags: body tissue, cribriform plate, elastin, european continental ancestry group, extracellular matrix

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4143-4154. doi:https://doi.org/10.1167/iovs.17-21474

Orientation of the Temporal Nerve Fiber Raphe in Healthy and in Glaucomatous Eyes Open Access

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Phillip Bedggood; Bao Nguyen; Graham Lakkis; Andrew Turpin; Allison M. McKendrick

Tags: eye, facial nerve temporal branch, glaucoma, fovea centralis

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4211-4217. doi:https://doi.org/10.1167/iovs.17-21995

Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation Open Access

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Ehab A. Tamimi; Jeffrey D. Pyne; Dominic K. Muli; Katelyn F. Axman; Stephen J. Howerton; Matthew R. Davis; Christopher A. Girkin; Jonathan P. Vande Geest

Tags: amputation stumps, optic nerve, sclera, eye, axon

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4235-4246. doi:https://doi.org/10.1167/iovs.17-22141

Vertical Macular Asymmetry Measures Derived From SD-OCT for Detection of Early Glaucoma Open Access

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Farideh Sharifipour; Esteban Morales; Ji Woong Lee; JoAnn Giaconi; Abdelmonem A. Afifi; Fei Yu; Joseph Caprioli; Kouros Nouri-Mahdavi

Tags: glaucoma, spectral domain-optical coherence tomography

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4310-4317. doi:https://doi.org/10.1167/iovs.17-21961

Immunology and Microbiology

Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis Open Access

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Christian Böni; Jennifer E. Thorne; Richard F. Spaide; Trucian A. Ostheimer; David Sarraf; Ralph D. Levinson; Debra A. Goldstein; Lana M. Rifkin; Albert T. Vitale; Glenn J. Jaffe; Gary N. Holland

Tags: eye, vitiliginous chorioretinitis, vision

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4015-4025. doi:https://doi.org/10.1167/iovs.17-21897

Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model Open Access

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Jian Li; Jialin Ren; Yolanda Wong Ying Yip; Xiaoyu Zhang; Kai On Chu; Tsz Kin Ng; Sun On Chan; Chi Pui Pang; Wai Kit Chu

Tags: animal model, autoimmunity, electroretinography, mice, diagnostic imaging

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4193-4200. doi:https://doi.org/10.1167/iovs.17-22436

Candida Species From Eye Infections: Drug Susceptibility, Virulence Factors, and Molecular Characterization Open Access

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Konduri Ranjith; Bhavani Sontam; Savitri Sharma; Joveeta Joseph; Kanchana N. Chathoth; Kalyana C. Sama; Somasheila I. Murthy; Sisinthy Shivaji

Tags: candida, disease susceptibility, eye infections, virulence factors, antifungal agents

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4201-4209. doi:https://doi.org/10.1167/iovs.17-22003

Lens

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis Open Access

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Yichen Wang; Anne M. Terrell; Brittany A. Riggio; Deepti Anand; Salil A. Lachke; Melinda K. Duncan

Tags: integrins, lens (device), lens, crystalline, egr1 gene, stress response

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3896-3922. doi:https://doi.org/10.1167/iovs.17-21721

Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice Open Access

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Peter J. Minogue; Junyuan Gao; Rebecca K. Zoltoski; Layne A. Novak; Richard T. Mathias; Eric C. Beyer; Viviana M. Berthoud

Tags: cataract, lens (device), lens, crystalline, mice, optics

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4366-4374. doi:https://doi.org/10.1167/iovs.17-21684

Multidisciplinary Ophthalmic Imaging

Analyzing and Predicting Visual Acuity Outcomes of Anti-VEGF Therapy by a Longitudinal Mixed Effects Model of Imaging and Clinical Data Open Access

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Wolf-Dieter Vogl; Sebastian M. Waldstein; Bianca S. Gerendas; Thomas Schlegl; Georg Langs; Ursula Schmidt-Erfurth

Tags: anti-vascular endothelial growth factor therapy, diagnostic imaging, visual acuity

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4173-4181. doi:https://doi.org/10.1167/iovs.17-21878

Physiology and Pharmacology

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs Open Access

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Kwangsic Joo; Sang Jun Park; Yewon Choi; Jung Eun Lee; Young Mi Na; Hye Kyoung Hong; Kyu Hyung Park; Ho Min Kim; Jae-Yong Chung; Se Joon Woo

Tags: cd40 ligand, half-life, telomeric repeat amplification protocol, thyroid hormone associated protein complex, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4261-4267. doi:https://doi.org/10.1167/iovs.17-21813

Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response Open Access

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Evan A. Thackaberry; Cindy Farman; Fiona Zhong; Florence Lorget; Karin Staflin; Angelique Cercillieux; Paul E. Miller; Chris Schuetz; Debby Chang; Amin Famili; Ann L. Daugherty; Karthik Rajagopal; Vladimir Bantseev

Tags: microspheres, oryctolagus cuniculus, rod photoreceptors, toxic effect, inflammatory response

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4274-4285. doi:https://doi.org/10.1167/iovs.16-21334

Retina

Modifications in Retinal Mitochondrial Respiration Precede Type 2 Diabetes and Protracted Microvascular Retinopathy Open Access

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Woo Hyun Han; Jonathan Gotzmann; Sharee Kuny; Hui Huang; Catherine B. Chan; Hélène Lemieux; Yves Sauvé

Tags: diabetes mellitus, type 2, electroretinography, mitochondria, respiration, retinal diseases

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3826-3839. doi:https://doi.org/10.1167/iovs.17-21929

Radiation Maculopathy After Proton Beam Therapy for Uveal Melanoma: Optical Coherence Tomography Angiography Alterations Influencing Visual Acuity Open Access

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Alexandre Matet; Alejandra Daruich; Leonidas Zografos

Tags: angiogram, macular disorders, optical coherence tomography, protons, radiation

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3851-3861. doi:https://doi.org/10.1167/iovs.17-22324

Effect of Methotrexate on an In Vitro Patient-Derived Model of Proliferative Vitreoretinopathy Open Access

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Dhanesh Amarnani; Arturo Israel Machuca-Parra; Lindsay L. Wong; Christina K. Marko; James A. Stefater; Tomasz P. Stryjewski; Dean Eliott; Joseph F. Arboleda-Velasquez; Leo A. Kim

Tags: methotrexate, tissue membrane, vitreoretinopathy, proliferative, immunohistochemistry

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3940-3949. doi:https://doi.org/10.1167/iovs.16-20912

Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy Open Access

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Johannes Birtel; Martin Gliem; Elisabeth Mangold; Lars Tebbe; Isabel Spier; Philipp L. Müller; Frank G. Holz; Christine Neuhaus; Uwe Wolfrum; Hanno J. Bolz; Peter Charbel Issa

Tags: ciliopathies, retinal diseases, phenotype

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3950-3959. doi:https://doi.org/10.1167/iovs.17-21679

The Distribution of Leakage on Fluorescein Angiography in Diabetic Macular Edema: A New Approach to Its Etiology Open Access

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Bilal Haj Najeeb; Christian Simader; Gabor Deak; Clemens Vass; Jutta Gamper; Alessio Montuoro; Bianca S. Gerendas; Ursula Schmidt-Erfurth

Tags: astrocytes, diabetic macular edema, fluorescein angiography

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3986-3990. doi:https://doi.org/10.1167/iovs.17-21510

Heritability of Retinal Vascular Fractals: A Twin Study Open Access

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Anna Stage Vergmann; Rebecca Broe; Line Kessel; Jesper Leth Hougaard; Sören Möller; Kirsten Ohm Kyvik; Michael Larsen; Inger Christine Munch; Jakob Grauslund

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3997-4002. doi:https://doi.org/10.1167/iovs.17-22072

Spatial Correspondence Between Intraretinal Fluid, Subretinal Fluid, and Pigment Epithelial Detachment in Neovascular Age-Related Macular Degeneration Open Access

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Sophie Klimscha; Sebastian M. Waldstein; Thomas Schlegl; Hrvoje Bogunović; Amir Sadeghipour; Ana-Maria Philip; Dominika Podkowinski; Eleonore Pablik; Li Zhang; Michael D. Abramoff; Milan Sonka; Bianca S. Gerendas; Ursula Schmidt-Erfurth

Tags: exudative age-related macular degeneration, retinal pigment epithelial detachment, eye, diagnostic imaging, choroidal neovascularization

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4039-4048. doi:https://doi.org/10.1167/iovs.16-20201

Analysis of Cone Mosaic Reflectance Properties in Healthy Eyes and in Eyes With Nonproliferative Diabetic Retinopathy Over Time Open Access

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Letizia Mariotti; Nicholas Devaney; Giuseppe Lombardo; Marco Lombardo

Tags: mosaicism, nonproliferative diabetic retinopathy, retinal cone, eye, diabetic retinopathy

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4057-4067. doi:https://doi.org/10.1167/iovs.17-21932

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study Open Access

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Koji Uesugi; Hirokazu Sakaguchi; Yasutaka Hayashida; Ryuhei Hayashi; Koichi Baba; Yuya Suganuma; Hidenori Yokoi; Motokazu Tsujikawa; Kohji Nishida

Tags: gel, oryctolagus cuniculus, peptides, vitreous substitute

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4068-4075. doi:https://doi.org/10.1167/iovs.17-21536

The Charles Bonnet Syndrome in Patients With Neovascular Age-Related Macular Degeneration: Association With Proton Pump Inhibitors Open Access

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João Esteves Leandro; João Beato; Ana Catarina Pedrosa; João Pinheiro-Costa; Manuel Falcão; Fernando Falcão-Reis; Ângela M. Carneiro

Tags: charles bonnet syndrome, exudative age-related macular degeneration, hallucinations, proton pump inhibitors, hallucinations, visual

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4138-4142. doi:https://doi.org/10.1167/iovs.16-21270

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae Open Access

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G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium

Tags: gene therapy, injections, primates, safety, serotonin uptake inhibitors

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4155-4160. doi:https://doi.org/10.1167/iovs.17-22402

Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration Open Access

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Mei Du; Eric Phelps; Michael J. Balangue; Aaron Dockins; Gennadiy Moiseyev; Younghwa Shin; Shelley Kane; Laura Otalora; Jian-Xing Ma; Rafal Farjo; Krysten M. Farjo

Tags: mice, retinal degeneration, mice, transgenic, electroretinography, retinoids

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4375-4383. doi:https://doi.org/10.1167/iovs.17-22107

Retinal Cell Biology

Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice Open Access

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Zhongjie Fu; Raffael Liegl; Zhongxiao Wang; Yan Gong; Chi-Hsiu Liu; Ye Sun; Bertan Cakir; Samuel B. Burnim; Steven S. Meng; Chatarina Löfqvist; John Paul SanGiovanni; Ann Hellström; Lois E. H. Smith

Tags: choroidal neovascularization, diet, lasers, mice, adiponectin

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3862-3870. doi:https://doi.org/10.1167/iovs.17-21796

Conditional, Genetically Encoded, Small Molecule–Regulated Inhibition of NFκB Signaling in RPE Cells Open Access

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Khiem T. Vu; Fang Zhang; John D. Hulleman

Tags: dihydrofolate reductase, retinal pigment cell, signal transduction, small molecule, stabilization

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4126-4137. doi:https://doi.org/10.1167/iovs.17-22133

Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation Open Access

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Bailey Baumann; Jacob Sterling; Ying Song; Delu Song; Marcus Fruttiger; Mark Gillies; Weiyong Shen; Joshua L. Dunaief

Tags: iron, retina, ablation, proteins

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4223-4234. doi:https://doi.org/10.1167/iovs.17-21743

Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro Open Access

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Frank Kung; Weiwei Wang; Tracy S. Tran; Ellen Townes-Anderson

Tags: rod photoreceptors, semaphorin-3a

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4318-4331. doi:https://doi.org/10.1167/iovs.16-21075

Homocysteine Facilitates Prominent Polygonal Angiogenetic Networks of a Choroidal Capillary Sprouting Model Open Access

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Yih-Jing Lee; Chien-Chao Chiu; Chia-Ying Ke; Ni Tien; Po-Kang Lin

Tags: blood capillaries, homocysteine, endothelial cells, platelet-derived growth factor

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4332-4343. doi:https://doi.org/10.1167/iovs.17-22308

Viral Retinopathy in Experimental Models of Zika Infection Open Access

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Zhenyang Zhao; Matthew Yang; Sasha R. Azar; Lynn Soong; Scott C. Weaver; Jiaren Sun; Yan Chen; Shannan L. Rossi; Jiyang Cai

Tags: infections, mice, retina, retinal diseases, zika virus

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4355-4365. doi:https://doi.org/10.1167/iovs.17-22016

Clinical Trials

Identification of Characters and Localization of Images Using Direct Multiple-Electrode Stimulation With a Suprachoroidal Retinal Prosthesis Open Access

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Mohit N. Shivdasani; Nicholas C. Sinclair; Lisa N. Gillespie; Matthew A. Petoe; Samuel A. Titchener; James B. Fallon; Thushara Perera; Darien Pardinas-Diaz; Nick M. Barnes; Peter J. Blamey; for the Bionic Vision Australia Consortium

Tags: accommodation phosphene, eye movement, personality character, vision, visual prosthesis

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3962-3974. doi:https://doi.org/10.1167/iovs.16-21311

New Developments in Vision Research

Peptide Nucleic Acid–Fluorescence In Situ Hybridization for Detection of Staphylococci From Endophthalmitis Isolates: A Proof-of-Concept Study Open Access

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Nimesh Patel; Darlene Miller; Nidhi Relhan; Harry W. Flynn, Jr

Tags: endophthalmitis, fluorescent in situ hybridization, peptide nucleic acids, staphylococcus

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4307-4309. doi:https://doi.org/10.1167/iovs.17-21535

Letters to the Editor

Do High mtDNA Copy Numbers Truly Prevent LHON Manifestations? Open Access

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Josef Finsterer

Tags: dna, mitochondrial, optic atrophy, hereditary, leber

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4076. doi:https://doi.org/10.1167/iovs.17-22307

Author Response: Do High mtDNA Copy Numbers Truly Prevent LHON Manifestations? Open Access

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Angelica Bianco; Vittoria Petruzzella

Tags: dna, mitochondrial, optic atrophy, hereditary, leber

Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4077. doi:https://doi.org/10.1167/iovs.17-22545

Erratum

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3960. doi:https://doi.org/10.1167/iovs.17-22339a

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 3961. doi:https://doi.org/10.1167/iovs.06-0464a

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4161. doi:https://doi.org/10.1167/iovs.16-20241a

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4210. doi:https://doi.org/10.1167/iovs.10-7130a

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4247. doi:https://doi.org/10.1167/iovs.17-21460a

Erratum Open Access

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Investigative Ophthalmology & Visual Science August 2017, Vol.58, 4248. doi:https://doi.org/10.1167/iovs.17-21675a

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