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Anatomy and Pathology/Oncology

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia Open Access
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Qianli Meng; Yaowu Qin; Monika Deshpande; Fabiana Kashiwabuchi; Murilo Rodrigues; Qiaozhi Lu; Hui Ren; Jennifer H. Elisseeff; Gregg L. Semenza; Silvia V. Montaner; Akrit Sodhi
Tags: angiogenesis, angiopoietins, hypoxia, phenotype, pterygium
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4514-4523. doi:https://doi.org/10.1167/iovs.17-21974
Anterior Chamber Invasion in Retinoblastoma: Not an Indication for Adjuvant Chemotherapy Open Access
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Kummamuri V. Sreelakshmi; Anita Chandra; Subramanian Krishnakumar; Viswanathan Natarajan; Vikas Khetan
Tags: adjuvant chemotherapy, anterior chamber of eye, eye, retinoblastoma, seeds
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4654-4661. doi:https://doi.org/10.1167/iovs.17-22111

Biochemistry and Molecular Biology

Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL Open Access
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Lina Zelinger; Gökhan Karakülah; Vijender Chaitankar; Jung-Woong Kim; Hyun-Jin Yang; Matthew J. Brooks; Anand Swaroop
Tags: genes, photoreceptors, regulation, rod photoreceptors, rna
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4422-4435. doi:https://doi.org/10.1167/iovs.17-21805
Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice Open Access
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Philip A. Ruzycki; Courtney D. Linne; Anne K. Hennig; Shiming Chen
Tags: mice, mutation, photoreceptors, retina, proteins
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4644-4653. doi:https://doi.org/10.1167/iovs.17-22075
Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina Open Access
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Pei Chen; Xiaoxiao Cai; Ying Yang; Zhao Chen; Jin Qiu; Na Yu; Mingjun Tang; Qiyun Wang; Jian Ge; Keming Yu; Jing Zhuang
Tags: cxcr4 receptors, retina, fibrinogen
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4662-4669. doi:https://doi.org/10.1167/iovs.17-22115

Clinical and Epidemiologic Research

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration Open Access
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Bénédicte M. J. Merle; Rachel E. Silver; Bernard Rosner; Johanna M. Seddon
Tags: age-related macular degeneration, diet, vitamin d, calcium
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4569-4578. doi:https://doi.org/10.1167/iovs.17-21673
Increased Mortality and Comorbidity Associated With Leber's Hereditary Optic Neuropathy: A Nationwide Cohort Study Open Access
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Nanna Vestergaard; Thomas Rosenberg; Christian Torp-Pedersen; Henrik Vorum; Carl U. Andersen; Kristian Aasbjerg
Tags: comorbidity, optic atrophy, hereditary, leber, mortality, cohort studies
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4586-4592. doi:https://doi.org/10.1167/iovs.17-21990
Myopia and Exposure to Organophosphate and Pyrethroid Pesticides in the General United States Population Open Access
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Vincent Migneron-Foisy; Maryse F. Bouchard; Ellen E. Freeman; Dave Saint-Amour
Tags: metabolites, myopia, pesticides, phosphoric acid esters, pyrethroids
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4915-4924. doi:https://doi.org/10.1167/iovs.16-20493

Cornea

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation Open Access
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Tarsis F. Gesteira; Mingxia Sun; Yvette M. Coulson-Thomas; Yu Yamaguchi; Lung-Kun Yeh; Vincent Hascall; Vivien J. Coulson-Thomas
Tags: alkalies, burns, cornea, hyaluronan, mice
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4407-4421. doi:https://doi.org/10.1167/iovs.17-22326
Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways Open Access
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Marit Lippestad; Robin R. Hodges; Tor P. Utheim; Charles N. Serhan; Darlene A. Dartt
Tags: bodily secretions, conjunctiva, glycoconjugates, goblet cells, mucins
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4530-4544. doi:https://doi.org/10.1167/iovs.17-21914
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy Open Access
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V. Vinod Mootha; Brock Hansen; Ziye Rong; Pradeep P. Mammen; Zhengyang Zhou; Chao Xing; Xin Gong
Tags: endothelium, hereditary corneal dystrophy, myotonic dystrophy, rna, trinucleotide repeats
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4579-4585. doi:https://doi.org/10.1167/iovs.17-22350
Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals Open Access
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David L. Williams; Barbara M. Wirostko; Glenwood Gum; Brenda K. Mann
Tags: cornea, corneal epithelial defect, dog, domestic, healing process, hyaluronic acid
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4616-4622. doi:https://doi.org/10.1167/iovs.16-20848
Spatiotemporally Controlled Ablation of Klf5 Results in Dysregulated Epithelial Homeostasis in Adult Mouse Corneas Open Access
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Chelsea L. Loughner; Anil Tiwari; Doreswamy Kenchegowda; Sudha Swamynathan; Shivalingappa K. Swamynathan
Tags: ablation, adult, cornea, epithelium, homeostasis
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4683-4693. doi:https://doi.org/10.1167/iovs.17-22498
Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration Open Access
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Guohu Di; Xia Qi; Xiaowen Zhao; Songmei Zhang; Patrik Danielson; Qingjun Zhou
Tags: cornea, corneal epithelium, epithelium, glial cell-line derived neurotrophic factor, nerve growth factors
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4695-4702. doi:https://doi.org/10.1167/iovs.16-21372
Astigmatism and Refractive Outcome After Late In-The-Bag Intraocular Lens Dislocation Surgery: A Randomized Clinical Trial Open Access
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Olav Kristianslund; Atle Einar Østern; Liv Drolsum
Tags: astigmatism, clinical trials, dislocations, intraocular lens implant device, surgical procedures, operative
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4747-4753. doi:https://doi.org/10.1167/iovs.17-22723
Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research Open Access
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Yujin Zhang; Winston W.-Y. Kao; Yasuhito Hayashi; Lingling Zhang; Mindy Call; Fei Dong; Yong Yuan; Jianhua Zhang; Yen-Chiao Wang; Okada Yuka; Atsushi Shiraishi; Chia-Yang Liu
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4800-4808. doi:https://doi.org/10.1167/iovs.17-22661
Prehematopoietic Stem Cell Transplantation Tear Cytokines as Potential Susceptibility Biomarkers for Ocular Chronic Graft-Versus-Host Disease Open Access
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Lidia Cocho; Itziar Fernández; Margarita Calonge; Maite Sainz de la Maza; Montserrat Rovira; Michael E. Stern; Carmen Garcia-Vazquez; Amalia Enríquez-de-Salamanca
Tags: biological markers, cytokine, disease susceptibility, graft-versus-host disease, chronic, hematopoietic stem cell transplantation
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4836-4846. doi:https://doi.org/10.1167/iovs.17-21670
Therapeutic Effect of MK2 Inhibitor on Experimental Murine Dry Eye Open Access
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Yang Wu; Jinghua Bu; Yiran Yang; Xiang Lin; Xiaoxin Cai; Caihong Huang; Xiaoxiang Zheng; Weijie Ouyang; Wei Li; Xiaobo Zhang; Zuguo Liu
Tags: administration, topical, conjunctiva, dry eye syndromes, mice, inflammation
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4898-4907. doi:https://doi.org/10.1167/iovs.17-22240

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Multifocal Visual Evoked Potential in Eyes With Temporal Hemianopia From Chiasmal Compression: Correlation With Standard Automated Perimetry and OCT Findings Open Access
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Rafael M. Sousa; Maria K. Oyamada; Leonardo P. Cunha; Mário L. R. Monteiro
Tags: compression, evoked potentials, visual, eye, hemianopsia, perimetry
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4436-4446. doi:https://doi.org/10.1167/iovs.17-21529

Glaucoma

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters Open Access
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Navid Amini; Ramin Daneshvar; Farideh Sharifipour; Pablo Romero; Sharon Henry; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: glaucoma, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4623-4631. doi:https://doi.org/10.1167/iovs.17-21936
Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA Open Access
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Shokichi Takahama; Modupe O. Adetunji; Tantai Zhao; Shan Chen; Wei Li; Stanislav I. Tomarev
Tags: amacrine cells, astrocytes, gamma-aminobutyric acid, neuroprotection, platelet-derived growth factor
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4703-4711. doi:https://doi.org/10.1167/iovs.21783
Evidence for Cerebrospinal Fluid Entry Into the Optic Nerve via a Glymphatic Pathway Open Access
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Emily Mathieu; Neeru Gupta; Amir Ahari; Xun Zhou; Joseph Hanna; Yeni H. Yücel
Tags: optic nerve, cerebrospinal fluid, injections
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4784-4791. doi:https://doi.org/10.1167/iovs.17-22290
Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging Open Access
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Ke Wang; Murray A. Johnstone; Chen Xin; Shaozhen Song; Steven Padilla; Janice A. Vranka; Ted S. Acott; Kai Zhou; Stephen A. Schwaner; Ruikang K. Wang; Todd Sulchek; C. Ross Ethier
Tags: body tissue, diagnostic imaging, eye, glaucoma, trabecular meshwork
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4809-4817. doi:https://doi.org/10.1167/iovs.17-22175
The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase Open Access
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Stefan Muenster; Wolfgang S. Lieb; Gregor Fabry; Kaitlin N. Allen; Shivani S. Kamat; Ann H. Guy; Ana C. Dordea; Leandro Teixeira; Robert E. Tainsh; Binglan Yu; Wei Zhu; Nicole E. Ashpole; Rajeev Malhotra; Peter Brouckaert; Donald B. Bloch; Marielle Scherrer-Crosbie; W. Daniel Stamer; Markus H. Kuehn; Louis R. Pasquale; Emmanuel S. Buys
Tags: eye, guanylate cyclase, intraocular pressure, mice, nitric oxide
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4826-4835. doi:https://doi.org/10.1167/iovs.17-22168

Immunology and Microbiology

Development of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis Open Access
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Andrew G. Gallagher; Keri McLean; Rosalind M. K. Stewart; Don A. Wellings; Heather E. Allison; Rachel L. Williams
Tags: antifungal agents, fungal keratitis, gel, contact lenses, lysine
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4499-4505. doi:https://doi.org/10.1167/iovs.17-22301
Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA Open Access
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Abirami Kugadas; Quentin Wright; Jennifer Geddes-McAlister; Mihaela Gadjeva
Tags: immunoglobulin a, immunoglobulin a, secretory, mice, microbiome, mucous membrane
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4593-4600. doi:https://doi.org/10.1167/iovs.17-22119
Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection Open Access
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Ana J. Chucair-Elliott; Hem R. Gurung; Meghan M. Carr; Daniel J. J. Carr
Tags: cornea, human herpesvirus 1, infections, macrophages, nerve degeneration
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4670-4682. doi:https://doi.org/10.1167/iovs.17-22159

Lens

A Role for Calcium-Activated Adenylate Cyclase and Protein Kinase A in the Lens Src Family Kinase and Na,K-ATPase Response to Hyposmotic Stress Open Access
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Mohammad Shahidullah; Amritlal Mandal; Nicholas A. Delamere
Tags: adenosine triphosphatases, adenylate cyclase, calcium, cyclic amp-dependent protein kinases, lens (device)
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4447-4456. doi:https://doi.org/10.1167/iovs.17-21600
Performing Reliable Lens Capsulotomy in the Presence of Corneal Edema With a Femtosecond Laser Open Access
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Geraint P. Williams; Benjamin L. George; Yoke R. Wong; Gary H. F. Yam; Marcus Ang; Shian C. Tay; Jodhbir S. Mehta
Tags: corneal edema, lens (device), lens, crystalline, cornea, in situ nick-end labeling
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4490-4498. doi:https://doi.org/10.1167/iovs.17-22227
Association Between Serum Complement C3 Levels and Age-Related Cataract Open Access
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Mingxi Shao; Danhui Li; Jisen Teng; Yudong Zhang; Shengjie Li; Wenjun Cao
Tags: cataract, senile, complement 3, serum complement, regression analysis
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4934-4939. doi:https://doi.org/10.1167/iovs.17-22522

Low Vision

Visual Search Behavior in Individuals With Retinitis Pigmentosa During Level Walking and Obstacle Crossing Open Access
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Matthew A. Timmis; Jon Allsop; Mohammad Baranian; James Baker; Itay Basevitch; Keziah Latham; Shahina Pardhan; Kjell N. van Paridon
Tags: gait, visual search, walking (activity), retinitis pigmentosa
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4737-4746. doi:https://doi.org/10.1167/iovs.17-21573

Multidisciplinary Ophthalmic Imaging

Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt–Koyanagi–Harada Disease Open Access
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Masahiro Miura; Shuichi Makita; Yoshiaki Yasuno; Rintaro Tsukahara; Yoshihiko Usui; Narsing A. Rao; Yasushi Ikuno; Sato Uematsu; Tetsuya Agawa; Takuya Iwasaki; Hiroshi Goto
Tags: melanins, optical coherence tomography, uveomeningoencephalitic syndrome, eye, choroid
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4467-4476. doi:https://doi.org/10.1167/iovs.17-22117
Automated Photoreceptor Cell Identification on Nonconfocal Adaptive Optics Images Using Multiscale Circular Voting Open Access
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Jianfei Liu; HaeWon Jung; Alfredo Dubra; Johnny Tam
Tags: retinal cone, photoreceptors, optics
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4477-4489. doi:https://doi.org/10.1167/iovs.16-21003
The Properties of Outer Retinal Band Three Investigated With Adaptive-Optics Optical Coherence Tomography Open Access
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Ravi S. Jonnal; Iwona Gorczynska; Justin V. Migacz; Mehdi Azimipour; Robert J. Zawadzki; John S. Werner
Tags: optical coherence tomography, optics, retinal cone, mosaicism
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4559-4568. doi:https://doi.org/10.1167/iovs.16-21138
Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography Open Access
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Olivier Thouvenin; Claude Boccara; Mathias Fink; Jose Sahel; Michel Pâques; Kate Grieve
Tags: cell motility, contrast media, diagnostic imaging, optical coherence tomography, retina
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4605-4615. doi:https://doi.org/10.1167/iovs.17-22375

Physiology and Pharmacology

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders Open Access
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Christian M. Felix; Sujin Lee; Marc H. Levin; Alan S. Verkman
Tags: cystic fibrosis transmembrane conductance regulator, dry eye syndromes, oryctolagus cuniculus, triazines, pharmacology
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4506-4513. doi:https://doi.org/10.1167/iovs.17-22525
P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush Open Access
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Hidehiro Oku; Seita Morishita; Taeko Horie; Teruyo Kida; Masashi Mimura; Shota Kojima; Tsunehiko Ikeda
Tags: mtor serine-threonine kinases, optic nerve, rapamycin, rats, monocyte chemoattractant protein-1
Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4877-4888. doi:https://doi.org/10.1167/iovs.17-22179

Retina

High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa Open Access
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Julia-Sophia Bellingrath; G. Alex Ochakovski; Immanuel P. Seitz; Susanne Kohl; Eberhart Zrenner; Nicola Hanig; Holger Prokisch; Bernhard H. Weber; Susan M. Downes; Simon Ramsden; Robert E. MacLaren; M. Dominik Fischer
Tags: cohort studies, disease progression, electroretinography, eye, mutation
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4457-4466. doi:https://doi.org/10.1167/iovs.17-22077
Peripheral Vascular Endothelial Dysfunction in Central Serous Chorioretinopathy Open Access
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Nan-Kai Wang; Yun Fu; Jung-Pan Wang; Eugene Yu-Chan Kang; An-Lun Wu; Yun-Ju Tseng; Lung-Kun Yeh; Kuan-Jen Chen; Wei-Chi Wu; Wan-Jing Ho; Chi-Chun Lai
Tags: central serous chorioretinopathy, endothelial dysfunction, endothelium
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4524-4529. doi:https://doi.org/10.1167/iovs.17-21825
Photoreceptor Layer Thickness Changes During Dark Adaptation Observed With Ultrahigh-Resolution Optical Coherence Tomography Open Access
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Chen D. Lu; ByungKun Lee; Julia Schottenhamml; Andreas Maier; Edward N. Pugh, Jr; James G. Fujimoto
Tags: bleach, dark adaptation, optical coherence tomography, photoreceptors, rod photoreceptors
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4632-4643. doi:https://doi.org/10.1167/iovs.17-22171
Comparison of Continuous-Wave and Micropulse Modulation in Retinal Laser Therapy Open Access
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Jenny Wang; Yi Quan; Roopa Dalal; Daniel Palanker
Tags: body tissue, laser therapy, lasers, oryctolagus cuniculus, choroid
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4722-4732. doi:https://doi.org/10.1167/iovs.17-21610
Intraretinal Correlates of Reticular Pseudodrusen Revealed by Autofluorescence and En Face OCT Open Access
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Maarjaliis Paavo; Winston Lee; John Merriam; Srilaxmi Bearelly; Stephen Tsang; Stanley Chang; Janet R. Sparrow
Tags: autofluorescence, diagnostic imaging, face, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4769-4777. doi:https://doi.org/10.1167/iovs.17-22338
Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography Open Access
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Maximilian Gabriel; Robert Kruger; Farnusch Shams-Mafi; Boris Hermann; Behrooz Zabihian; Leopold Schmetterer; Wolfgang Drexler; Susanne Binder; Marieh Esmaeelpour
Tags: optical coherence tomography, uveitis, anterior, choroid, eye, maps
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4778-4783. doi:https://doi.org/10.1167/iovs.17-22265
Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration Open Access
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Enrico Borrelli; Akihito Uji; David Sarraf; SriniVas R. Sadda
Tags: age-related macular degeneration, chief complaint, drusen, eye
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4792-4798. doi:https://doi.org/10.1167/iovs.17-22360
Evaluating the Relationship Between Visual Acuity and Utilities in Patients With Diabetic Macular Edema Enrolled in Intravitreal Aflibercept Studies Open Access
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John Brazier; Dominic Muston; Henrietta Konwea; G. Sarah Power; Victor Barzey; Adam Lloyd; Olaf Sowade; Bob Vitti; Christoph Gerlinger; Jennifer Roberts
Tags: aflibercept, diabetic macular edema, visual acuity, health
Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4818-4825. doi:https://doi.org/10.1167/iovs.17-21945
Fluorescence Lifetimes of Drusen in Age-Related Macular Degeneration Open Access
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Chantal Dysli; Rahel Fink; Sebastian Wolf; Martin S. Zinkernagel
Tags: age-related macular degeneration, diagnostic imaging, drusen, fluorescence, retinal drusen
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4856-4862. doi:https://doi.org/10.1167/iovs.17-22184
Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy Open Access
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Yoshihiro Kaizu; Shintaro Nakao; Shigeo Yoshida; Takehito Hayami; Mitsuru Arima; Muneo Yamaguchi; Iori Wada; Toshio Hisatomi; Yasuhiro Ikeda; Tatsuro Ishibashi; Koh-Hei Sonoda
Tags: blood capillaries, angiogram, diabetic retinopathy, diabetes mellitus, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4889-4897. doi:https://doi.org/10.1167/iovs.17-22306
Histologic Characterization of Retina Neuroglia Modifications in Diabetic Zucker Diabetic Fatty Rats Open Access
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Ivan Fernandez-Bueno; Robert Jones; Laura Soriano-Romaní; Antonio López-García; Orla Galvin; Sharon Cheetham; Yolanda Diebold
Tags: diabetes mellitus, neuroglia, rats, retina, hemoglobin a, glycosylated
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4925-4933. doi:https://doi.org/10.1167/iovs.17-21742

Retinal Cell Biology

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa Open Access
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Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon; Sylvia B. Smith
Tags: mice, retina, photoreceptors, retinitis pigmentosa
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4545-4558. doi:https://doi.org/10.1167/iovs.17-21947
The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure Open Access
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Yusuke Shiode; Yuki Morizane; Ryo Matoba; Masayuki Hirano; Shinichiro Doi; Shinji Toshima; Kosuke Takahashi; Ryoichi Araki; Yuki Kanzaki; Mika Hosogi; Tomoko Yonezawa; Atsushi Yoshida; Fumio Shiraga
Tags: 5-lipoxygenase-activating protein, fibroblast growth factor 2, macular holes, surgical flaps, tissue membrane
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4847-4855. doi:https://doi.org/10.1167/iovs.17-21756
Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury Open Access
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Goichi Akiyama; Yuriko Azuchi; Xiaoli Guo; Takahiko Noro; Atsuko Kimura; Chikako Harada; Kazuhiko Namekata; Takayuki Harada
Tags: edaravone, mice, optic nerve injuries, retinal degeneration, adult
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4908-4914. doi:https://doi.org/10.1167/iovs.17-22250

Visual Neuroscience

Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors Open Access
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Sheng-Nan Qiao; Wei Zhou; Lei-Lei Liu; Dao-Qi Zhang; Yong-Mei Zhong
Tags: dopamine, orexins, photoreceptors, amacrine cells, melanopsin
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4712-4721. doi:https://doi.org/10.1167/iovs.17-21835
Differential Effects of HCN Channel Block on On and Off Pathways in the Retina as a Potential Cause for Medication-Induced Phosphene Perception Open Access
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Sebastian Bemme; Michael Weick; Tim Gollisch
Tags: accommodation phosphene, ganglia, ivabradine, perception, pharmaceutical preparations
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4754-4767. doi:https://doi.org/10.1167/iovs.17-21572

Visual Psychophysics and Physiological Optics

Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field Open Access
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Jack Phu; Sieu K. Khuu; Lisa Nivison-Smith; Barbara Zangerl; Agnes Yiu Jeung Choi; Bryan W. Jones; Rebecca L. Pfeiffer; Robert E. Marc; Michael Kalloniatis
Tags: contrast sensitivity, pattern recognition, perimetry, visual fields
Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4863-4876. doi:https://doi.org/10.1167/iovs.17-22371

Letters to the Editor

Optic Nerve Sheath Distention as a Protective Mechanism Against the Visual Impairment and Intracranial Pressure Syndrome in Astronauts Open Access
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Peter Wostyn; Peter Paul De Deyn
Tags: astronauts, dilatation, pathologic, intracranial pressure, optic nerve sheath, syndrome
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4601-4602. doi:https://doi.org/10.1167/iovs.17-22600
Author Response: Optic Nerve Sheath Distention as a Protective Mechanism Against the Visual Impairment and Intracranial Pressure Syndrome in Astronauts Open Access
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Thomas H. Mader; C. Robert Gibson; Andrew G. Lee
Tags: astronauts, dilatation, pathologic, intracranial pressure, optic nerve sheath, syndrome
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4603-4604. doi:https://doi.org/10.1167/iovs.17-22779
Comment on “Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism” Open Access
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Brian S. McKay; Ronald M. Lynch; W. Daniel Stamer
Tags: albinism, ocular, g-protein-coupled receptors, ligands, pharmacology, x-linked inheritance
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4733-4734. doi:https://doi.org/10.1167/iovs.17-22660
Author Response: Comment on “Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism” Open Access
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Elisabetta De Filippo; Prashiela Manga; Anke C. Schiedel
Tags: albinism, ocular, g-protein-coupled receptors, ligands, pharmacology, x-linked inheritance
Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4735-4736. doi:https://doi.org/10.1167/iovs.17-22810

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4694. doi:https://doi.org/10.1167/iovs.15-16600a
Erratum Open Access
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Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4768. doi:https://doi.org/10.1167/iovs.15-17104a
Erratum Open Access
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Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4799. doi:https://doi.org/10.1167/iovs.17-22948
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