Volume 58 Issue 12 | IOVS

Another Piece of the Puzzle: MYOC and Myocilin Glaucoma Open Access

M. Elizabeth Fini

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5319. doi:https://doi.org/10.1167/iovs.17-23045

Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell Characteristics Open Access

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Rachel E. Doherty; Karen Sisley; David W. Hammond; Ian G. Rennie; Neil A. Cross

Tags: aldehyde dehydrogenases, cancer stem cells, cd44 antigens, cell lines, homing-associated cell adhesion molecule

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5387-5395. doi:https://doi.org/10.1167/iovs.17-22272

SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas Open Access

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Taisuke Mori; Aoi Sukeda; Shigeki Sekine; Shinsuke Shibata; Eijitsu Ryo; Hideyuki Okano; Shigenobu Suzuki; Nobuyoshi Hiraoka

Tags: braf gene, ciliary epithelium, mutation, neoplasms, pigment

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5445-5451. doi:https://doi.org/10.1167/iovs.17-22362

Biochemistry and Molecular Biology

A PPAR-Gamma Agonist Rosiglitazone Suppresses Fibrotic Response in Human Pterygium Fibroblasts by Modulating the p38 MAPK Pathway Open Access

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Selikem Abla Nuwormegbe; Joon Hyung Sohn; Sun Woong Kim

Tags: fibroblasts, mitogen-activated protein kinase p38, peroxisome proliferator-activated receptors, pterygium, rosiglitazone

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5217-5226. doi:https://doi.org/10.1167/iovs.17-22203

A Computational Approach From Gene to Structure Analysis of the Human ABCA4 Transporter Involved in Genetic Retinal Diseases Open Access

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Alfonso Trezza; Andrea Bernini; Andrea Langella; David B. Ascher; Douglas E. V. Pires; Andrea Sodi; Ilaria Passerini; Elisabetta Pelo; Stanislao Rizzo; Neri Niccolai; Ottavia Spiga

Tags: genes, genetics, membrane transport proteins, proteins, retinal diseases

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5320-5328. doi:https://doi.org/10.1167/iovs.17-22158

Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy Open Access

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Guohong Zhou; Yajiang Duan; Gaoen Ma; Wenyi Wu; Zhengping Hu; Na Chen; Yewlin Chee; Jing Cui; Arif Samad; Joanne A. Matsubara; Shizuo Mukai; Patricia A. D'Amore; Hetian Lei

Tags: epithelial cells, mutation, oryctolagus cuniculus, vitreoretinopathy, proliferative, vitreous body

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5361-5367. doi:https://doi.org/10.1167/iovs.17-22045

Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells Open Access

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Emi Nakajima; Katherine B. Hammond; Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma

Tags: calpain, caspases, hypoxia, retinal pigment cell, cercopithecidae

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5412-5420. doi:https://doi.org/10.1167/iovs.17-22325

Clinical and Epidemiologic Research

Conjunctival Melanoma in Chinese Patients: Local Recurrence, Metastasis, Mortality, and Comparisons With Caucasian Patients Open Access

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Chuandi Zhou; Yuxin Wang; Renbing Jia; Xianqun Fan

Tags: chinese (other dialects), chinese people, european continental ancestry group, malignant melanoma of conjunctiva, mortality

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5452-5459. doi:https://doi.org/10.1167/iovs.17-22376

Cornea

Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1 Open Access

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Sonali Pal-Ghosh; Gauri Tadvalkar; Mary Ann Stepp

Tags: cd138, cornea, mice, wounds and injuries, axon

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4959-4975. doi:https://doi.org/10.1167/iovs.17-21531

Corneal Mesenchymal Stromal Cells Are Directly Antiangiogenic via PEDF and sFLT-1 Open Access

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Medi Eslani; Ilham Putra; Xiang Shen; Judy Hamouie; Neda Afsharkhamseh; Soroush Besharat; Mark I. Rosenblatt; Reza Dana; Peiman Hematti; Ali R. Djalilian

Tags: angiogenesis inhibitors, cornea, soluble fms-like tyrosine kinase 1, mesenchymal stem cells

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5507-5517. doi:https://doi.org/10.1167/iovs.17-22680

Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome Open Access

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Isobel Massie; Kristina Spaniol; Andreas Barbian; Gereon Poschmann; Kai Stühler; Gerd Geerling; Marco Metzger; Sonja Mertsch; Stefan Schrader

Tags: dry eye syndromes, epithelial cells, jejunum, reconstructive surgical procedures, suidae

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5564-5574. doi:https://doi.org/10.1167/iovs.16-20759

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Axonal Protection by Ripasudil, a Rho Kinase Inhibitor, via Modulating Autophagy in TNF-Induced Optic Nerve Degeneration Open Access

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Yasushi Kitaoka; Kana Sase; Chihiro Tsukahara; Kaori Kojima; Akira Shiono; Jiro Kogo; Naoto Tokuda; Hitoshi Takagi

Tags: autophagy, axon, kinase inhibitors, optic nerve, tissue degeneration

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5056-5064. doi:https://doi.org/10.1167/iovs.17-22000

Palisade Endings of Extraocular Muscles Develop Postnatally Following Different Time Courses Open Access

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Roland Blumer; Johannes Streicher; María A. Davis-López de Carrizosa; Rosa R. de la Cruz; Angel M. Pastor

Tags: adult, axon, extra-ocular rectus muscles, medial rectus muscle, muscle

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5105-5121. doi:https://doi.org/10.1167/iovs.17-22643

Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography Open Access

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Melinda Y. Chang; Nopasak Phasukkijwatana; Sean Garrity; Stacy L. Pineles; Mansour Rahimi; David Sarraf; Mollie Johnston; Andrew Charles; Anthony C. Arnold

Tags: angiogram, aura, migraine disorders, migraine with aura, optical coherence tomography

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5477-5484. doi:https://doi.org/10.1167/iovs.17-22477

Ocular Torsion According to Trochlear Nerve Absence in Unilateral Superior Oblique Palsy Open Access

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Ji Eun Lee; Hee Kyung Yang; Jae Hyoung Kim; Jeong-Min Hwang

Tags: eye, fourth cranial nerve palsy, musculoskeletal torsion, function, standard operating procedure, torsion

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5526-5531. doi:https://doi.org/10.1167/iovs.17-22452

Genetics

A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma Open Access

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Mohsen Ghanbari; Adriana I. Iglesias; Henriët Springelkamp; Cornelia M. van Duijn; M. Arfan Ikram; Abbas Dehghan; Stefan J. Erkeland; Caroline C. W. Klaver; Magda A. Meester-Smoor; for the International Glaucoma Genetics Consortium (IGGC)

Tags: glaucoma, micrornas, open-angle glaucoma, genetics, endophenotypes

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5368-5377. doi:https://doi.org/10.1167/iovs.17-22410

Optic Nerve Hypoplasia Is a Pervasive Subcortical Pathology of Visual System in Neonates Open Access

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Chen Liang; Alicia Kerr; Yangfengzhong Qiu; Francesca Cristofoli; Hilde Van Esch; Michael A. Fox; Konark Mukherjee

Tags: haploinsufficiency, mice, newborn, optic disk, optic nerve

Investigative Ophthalmology & Visual Science November 2017, Vol.58, 5485-5496. doi:https://doi.org/10.1167/iovs.17-22399

Glaucoma

Genetic Deletion of the NOS3 Gene in CAV1^−/− Mice Restores Aqueous Humor Outflow Function Open Access

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Maomao Song; Jihong Wu; Yuan Lei; Xinghuai Sun

Tags: aqueous humor, mice, intraocular pressure, genetics, genes

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4976-4987. doi:https://doi.org/10.1167/iovs.16-21072

Impact of Myopia on Corneal Biomechanics in Glaucoma and Nonglaucoma Patients Open Access

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Sunee Chansangpetch; Rawiphan Panpruk; Anita Manassakorn; Visanee Tantisevi; Prin Rojanapongpun; Cameron P. Hurst; Shan C. Lin

Tags: biomechanics, cornea, glaucoma, myopia, open-angle glaucoma

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4990-4996. doi:https://doi.org/10.1167/iovs.17-22219

Progressive Deformation of the Optic Nerve Head and Peripapillary Structures by Graded Horizontal Duction Open Access

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Soh Youn Suh; Alan Le; Andrew Shin; Joseph Park; Joseph L. Demer

Tags: adduction, optic disk, abduction, gaze, displacements

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5015-5021. doi:https://doi.org/10.1167/iovs.17-22596

Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma Open Access

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Sushma Verma; Monisha E. Nongpiur; Hnin H. Oo; Eray Atalay; David Goh; Tina T. Wong; Shamira A. Perera; Tin Aung

Tags: angle closure glaucoma, optical coherence tomography, plateau iris, ultrasound biomicroscopy

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5093-5097. doi:https://doi.org/10.1167/iovs.17-22364

Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo Open Access

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Hanhan Liu; Fabian Anders; Solon Thanos; Carolina Mann; Aiwei Liu; Franz H. Grus; Norbert Pfeiffer; Verena Prokosch-Willing

Tags: glaucoma, hydrogen sulfide, intraocular pressure, wounds and injuries, retinal ganglion cells

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5129-5141. doi:https://doi.org/10.1167/iovs.17-22200

Effect of Body Position on Epsicleral Venous Pressure in Healthy Subjects Open Access

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Nitika Arora; Jay W. McLaren; David O. Hodge; Arthur J. Sit

Tags: eye, intraocular pressure, sitting position, venous pressure level, posture

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5151-5156. doi:https://doi.org/10.1167/iovs.17-22154

Intraday Repeatability of Bruch's Membrane Opening-Based Neuroretinal Rim Measurements Open Access

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Philip Enders; Andreas Bremen; Friederike Schaub; Manuel M. Hermann; Michael Diestelhorst; Thomas Dietlein; Claus Cursiefen; Ludwig M. Heindl

Tags: bruch's basal membrane, glaucoma, optic disk, magnetic resonance angiography

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5195-5200. doi:https://doi.org/10.1167/iovs.17-22812

Patients With Normal Tension Glaucoma Have Relative Sparing of the Relative Afferent Pupillary Defect Compared to Those With Open Angle Glaucoma and Elevated Intraocular Pressure Open Access

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Mitchell Lawlor; Ana Quartilho; Catey Bunce; Neil Nathwani; Emily Dowse; Debbie Kamal; Gus Gazzard

Tags: low tension glaucoma, open-angle glaucoma, pathophysiology, pupil, raised intraocular pressure

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5237-5241. doi:https://doi.org/10.1167/iovs.17-21688

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells Open Access

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Kate E. Keller; John M. Bradley; Ying Ying Sun; Yong-Feng Yang; Ted S. Acott

Tags: actins, body tissue, cellular structures, trabecular meshwork, transfer technique

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5298-5307. doi:https://doi.org/10.1167/iovs.17-22732

Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3 Open Access

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Myung Kuk Joe; Raquel L. Lieberman; Naoki Nakaya; Stanislav I. Tomarev

Tags: myoc gene, proteins, metalloproteases, eye

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5308-5318. doi:https://doi.org/10.1167/iovs.16-20336

Clinical and Biological Evaluations of Biodegradable Collagen Matrices for Glaucoma Drainage Device Implantation Open Access

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Minjung Song; Seunghyun Lee; Deokyeong Choe; Sera Kim; Young Hoon Roh; Seungsoo Rho

Tags: catabolism, collagen, glaucoma drainage implants, implantation procedure, language morphology

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5329-5335. doi:https://doi.org/10.1167/iovs.17-22579

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult Open Access

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Andrew P. Voorhees; Ning-Jiun Jan; Morgan E. Austin; John G. Flanagan; Jeremy M. Sivak; Richard A. Bilonick; Ian A. Sigal

Tags: cribriform plate, nerve tissue, shape, stress, intraocular pressure

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5336-5346. doi:https://doi.org/10.1167/iovs.17-22015

Elevated Intraocular Pressure Induces Amyloid-β Deposition and Tauopathy in the Lateral Geniculate Nucleus in a Monkey Model of Glaucoma Open Access

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Zhichao Yan; Huanquan Liao; Hongrui Chen; Shuifeng Deng; Yu Jia; Caibin Deng; Jianxian Lin; Jian Ge; Yehong Zhuo

Tags: alzheimer's disease, amyloid, glaucoma, raised intraocular pressure, tauopathies

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5434-5443. doi:https://doi.org/10.1167/iovs.17-22312

Immunology and Microbiology

The Anti-Inflammatory Effect of Ripasudil (K-115), a Rho Kinase (ROCK) Inhibitor, on Endotoxin-Induced Uveitis in Rats Open Access

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Takatoshi Uchida; Megumi Honjo; Reiko Yamagishi; Makoto Aihara

Tags: anti-inflammatory agents, aqueous humor, endotoxins, injections, mass or substance concentration per volume

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5584-5593. doi:https://doi.org/10.1167/iovs.17-22679

Lens

Cataract Avoidance With Proton Therapy in Ocular Melanomas Open Access

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Juliette Thariat; Sophie Jacob; Jean-Pierre Caujolle; Celia Maschi; Stéphanie Baillif; Gaelle Angellier; Thibaud Mathis; Laurence Rosier; Adela Carnicer; Joel Hérault; Julia Salleron

Tags: cataract, eye neoplasms, lens (device), lens, crystalline, proton therapy

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5378-5386. doi:https://doi.org/10.1167/iovs.17-22557

Multidisciplinary Ophthalmic Imaging

Wide-Field OCT Angiography Investigation of the Relationship Between Radial Peripapillary Capillary Plexus Density and Nerve Fiber Layer Thickness Open Access

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Yali Jia; Joseph M. Simonett; Jie Wang; Xiaohui Hua; Liang Liu; Thomas S. Hwang; David Huang

Tags: angiogram, blood capillaries, nerve fibers, eye

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5188-5194. doi:https://doi.org/10.1167/iovs.17-22593

Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer Open Access

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Kimikazu Sakaguchi; Tomomi Higashide; Sachiko Udagawa; Shinji Ohkubo; Kazuhisa Sugiyama

Tags: glaucoma, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5251-5262. doi:https://doi.org/10.1167/iovs.17-21955

The Effect of Acutely Elevated Intraocular Pressure on the Functional and Blood Flow Responses of the Rat Retina to Flicker Stimulation Open Access

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Bingyao Tan; Benjamin MacLellan; Erik Mason; Kostadinka K. Bizheva

Tags: electroretinography, intraocular pressure, photopsia, raised intraocular pressure, retina

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5532-5540. doi:https://doi.org/10.1167/iovs.17-22412

Characterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging Open Access

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Jasleen K. Jolly; Kanmin Xue; Thomas L. Edwards; Markus Groppe; Robert E. MacLaren

Tags: choroideremia, eye, natural history, retinal imaging, vision

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5575-5583. doi:https://doi.org/10.1167/iovs.17-22486

Physiology and Pharmacology

Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration Open Access

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Fangfang Qiu; Greg Matlock; Qian Chen; Kelu Zhou; Yanhong Du; Xiang Wang; Jian-Xing Ma

Tags: choroidal neovascularization, exhaled nitric oxide, lasers, ppar alpha, exudative age-related macular degeneration

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5065-5075. doi:https://doi.org/10.1167/iovs.17-22091

Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers Open Access

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Hao Li; Wenzhong Liu; Christine M. Sorenson; Nader Sheibani; Daniel M. Albert; Thulani Senanayake; Serguei Vinogradov; Jack Henkin; Hao F. Zhang

Tags: arginine, diffusion, nanoparticles, peptides, vitreous body

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5142-5150. doi:https://doi.org/10.1167/iovs.17-22160

Hypoxic, Hypercapnic, and Hyperoxic Responses of the Optic Nerve Head and Subfoveal Choroid Blood Flow in Healthy Humans Open Access

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Mathilde Gallice; Thierry Zhou; Florent Aptel; Samuel Verges; Charles Riva; Martial Geiser; Christophe Chiquet

Tags: choroid, gas mixture, hypercapnia, hyperoxia, hypoxia

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5460-5467. doi:https://doi.org/10.1167/iovs.17-21855

Retina

Imaging Lenticular Autofluorescence in Older Subjects Open Access

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Jason Charng; Rose Tan; Chi D. Luu; Sam Sadigh; Dwight Stambolian; Robyn H. Guymer; Samuel G. Jacobson; Artur V. Cideciyan

Tags: autofluorescence, diagnostic imaging, lens (device), lens, crystalline, eye

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4940-4947. doi:https://doi.org/10.1167/iovs.17-22540

Arrested Foveal Development in Preterm Eyes: Thickening of the Outer Nuclear Layer and Structural Redistribution Within the Fovea Open Access

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Johan Sjöstrand; Rebecka Rosén; Maria Nilsson; Zoran Popovic

Tags: eye, fovea centralis, photoreceptors, retina

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4948-4958. doi:https://doi.org/10.1167/iovs.17-22333

Effects of Intravitreal Dexamethasone Implants on Retinal Oxygen Saturation, Vessel Diameter, and Retrobulbar Blood Flow Velocity in ME Secondary to RVO Open Access

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Katharina Eibenberger; Leopold Schmetterer; Sandra Rezar-Dreindl; Piotr Wozniak; Reinhard Told; Georgios Mylonas; Christoph Krall; Ursula Schmidt-Erfurth; Stefan Sacu

Tags: alveolar ventilation function, blood flow velocity, cell respiration, dexamethasone, diameter

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5022-5029. doi:https://doi.org/10.1167/iovs.17-22229

Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy Open Access

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Guotao Deng; Elizabeth P. Moran; Rui Cheng; Greg Matlock; Kelu Zhou; David Moran; Danyang Chen; Qiang Yu; Jian-Xing Ma

Tags: agonists, diabetes mellitus, diabetic retinopathy, ppar alpha, retina

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5030-5042. doi:https://doi.org/10.1167/iovs.16-21402

Changes in Choroidal Blood Flow and Morphology in Response to Increase in Intraocular Pressure Open Access

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Tomohiko Akahori; Takeshi Iwase; Kentaro Yamamoto; Eimei Ra; Hiroko Terasaki

Tags: intraocular pressure, vascular flow, language morphology, morphology, choroid

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5076-5085. doi:https://doi.org/10.1167/iovs.17-21745

Effect of Circulating Omentin-1 on the Retinal Circulation in Patients With Type 2 Diabetes Mellitus Open Access

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Tsuneaki Omae; Taiji Nagaoka; Akitoshi Yoshida

Tags: diabetes mellitus, type 2, retina circulation, vascular flow

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5086-5092. doi:https://doi.org/10.1167/iovs.17-22030

Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration Open Access

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Fang Zheng; Qinqin Zhang; Elie H. Motulsky; João Rafael de Oliveira Dias; Chieh-Li Chen; Zhongdi Chu; Andrew R. Miller; William Feuer; Giovanni Gregori; Sophie Kubach; Mary K. Durbin; Ruikang K. Wang; Philip J. Rosenfeld

Tags: age-related macular degeneration, angiogram, choroidal neovascularization

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5098-5104. doi:https://doi.org/10.1167/iovs.17-22506

Associations Between Outer Retinal Structures and Focal Macular Electroretinograms in Patients With Retinitis Pigmentosa Open Access

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Taro Kominami; Shinji Ueno; Azusa Kominami; Ayami Nakanishi; Shunsuke Yasuda; Chang-Hua Piao; Satoshi Okado; Hiroko Terasaki

Tags: electroretinography, retinitis pigmentosa, spectral domain-optical coherence tomography, eye, wave - physical agent

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5122-5128. doi:https://doi.org/10.1167/iovs.17-22040

Evidence of Carotenoid in Surgically Removed Lamellar Hole-Associated Epiretinal Proliferation Open Access

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Akira Obana; Hiroyuki Sasano; Shigetoshi Okazaki; Yoshiro Otsuki; Takahiko Seto; Yuko Gohto

Tags: carotenoids, macular pigment, pigment, surgical procedures, operative

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5157-5163. doi:https://doi.org/10.1167/iovs.17-22347

Bone Marrow–Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy Open Access

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Sergio Caballero; David L. Kent; Nilanjana Sengupta; Sergio Li Calzi; Lynn Shaw; Eleni Beli; Leni Moldovan; James M. Dominguez, II; Ramana S. Moorthy; Maria B. Grant

Tags: bone marrow, bone marrow cells, choroid, lasers, mice

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5164-5176. doi:https://doi.org/10.1167/iovs.16-20736

Optical Coherence Tomography Angiography in the Evaluation of Geographic Atrophy Area Extension Open Access

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Eleonora Corbelli; Riccardo Sacconi; Alessandro Rabiolo; Stefano Mercuri; Adriano Carnevali; Lea Querques; Francesco Bandello; Giuseppe Querques

Tags: angiogram, atrophy, extension, face, optical coherence tomography

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5201-5208. doi:https://doi.org/10.1167/iovs.17-22508

Retinal Changes in Different Grades of Retinal Artery Occlusion: An Optical Coherence Tomography Study Open Access

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Olga Furashova; Egbert Matthé

Tags: central retinal artery occlusion, eye, optical coherence tomography, optics, retinal artery occlusion

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5209-5216. doi:https://doi.org/10.1167/iovs.17-22411

A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease Open Access

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Vivienne C. Greenstein; Jason Nunez; Winston Lee; Kaspar Schuerch; Brad Fortune; Stephen H. Tsang; Rando Allikmets; Janet R. Sparrow; Donald C. Hood

Tags: face, fundus autofluorescence imaging, optical coherence tomography, stargardt's disease

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5227-5236. doi:https://doi.org/10.1167/iovs.17-22532

CD11b and CD200 on Circulating Monocytes Differentiate Two Angiographic Subtypes of Polypoidal Choroidal Vasculopathy Open Access

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Yousif Subhi; Marie Krogh Nielsen; Christopher Rue Molbech; Akio Oishi; Amardeep Singh; Mogens Holst Nissen; Torben Lykke Sørensen

Tags: angiogram, exudative age-related macular degeneration, macrophage-1 antigen, monocytes, vascular diseases

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5242-5250. doi:https://doi.org/10.1167/iovs.17-22479

The Diameter of Retinal Vessels Is Affected by Transient Ischemia of the Arm in Normal Persons Open Access

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Yasmin El Dabagh; Line Petersen; Michael Pedersen; Toke Bek

Tags: diameter, retinal vessels, transient ischemia, arteriole, ischemia

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5263-5269. doi:https://doi.org/10.1167/iovs.17-22461

Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina Open Access

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Kaitlin Kogachi; Jeremy D. Wolfe; Amir H. Kashani

Tags: retina, retinal detachment, spectral domain-optical coherence tomography, surgical procedures, operative, postoperative care

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5270-5279. doi:https://doi.org/10.1167/iovs.17-22737

Factors Affecting Mydriasis-Free Flicker ERGs Recorded With Real-Time Correction for Retinal Illuminance: Study of 150 Young Healthy Subjects Open Access

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Kumiko Kato; Mineo Kondo; Ryunosuke Nagashima; Asako Sugawara; Masahiko Sugimoto; Hisashi Matsubara; Daphne L. McCulloch; Kengo Ikesugi

Tags: electroretinography, mydriasis, photopsia, pupil

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5280-5286. doi:https://doi.org/10.1167/iovs.17-22587

Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa Open Access

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Ke Wang; Bo Peng; Jia Xiao; Orly Weinreb; Moussa B. H. Youdim; Bin Lin

Tags: iron, mice, retina, retinal cone, retinitis pigmentosa

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5287-5297. doi:https://doi.org/10.1167/iovs.17-22096

The Nine-Step Minnesota Grading System for Eyebank Eyes With Age Related Macular Degeneration: A Systematic Approach to Study Disease Stages Open Access

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Timothy W. Olsen; Albert Liao; Hershonna S. Robinson; Neal V. Palejwala; Nicholas Sprehe

Tags: drusen, eye, grading system, age-related macular degeneration

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5497-5506. doi:https://doi.org/10.1167/iovs.17-22161

Temporal Properties of Flicker ERGs in Rabbit Model of Retinitis Pigmentosa Open Access

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Satoshi Okado; Shinji Ueno; Taro Kominami; Ayami Nakanishi; Daiki Inooka; Akira Sayo; Mineo Kondo; Hiroko Terasaki

Tags: oryctolagus cuniculus, photopsia, retinitis pigmentosa, spatial vectors, disease vectors

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5518-5525. doi:https://doi.org/10.1167/iovs.17-22332

Regional Patterns of Retinal Oxygen Saturation and Microvascular Hemodynamic Parameters Preceding Retinopathy in Patients With Type II Diabetes Open Access

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Julia Hafner; Laurin Ginner; Sonja Karst; Rainer Leitgeb; Michael Unterluggauer; Stefan Sacu; Christoph Mitsch; Christoph Scholda; Eleonore Pablik; Ursula Schmidt-Erfurth

Tags: diabetes mellitus, type 2, hemodynamic measurements, oxygen saturation measurement, retinal diseases, hemodynamics

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5541-5547. doi:https://doi.org/10.1167/iovs.17-22523

Quantitative Analysis of Three Distinct Retinal Capillary Plexuses in Healthy Eyes Using Optical Coherence Tomography Angiography Open Access

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Sean T. Garrity; Nicholas A. Iafe; Nopasak Phasukkijwatana; Xuejing Chen; David Sarraf

Tags: angiogram, blood capillaries, eye, optical coherence tomography, artifacts

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5548-5555. doi:https://doi.org/10.1167/iovs.17-22036

Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy Open Access

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Norman P. Blair; Justin Wanek; Anthony E. Felder; Charlotte E. Joslin; Jacob K. Kresovich; Jennifer I. Lim; Felix Y. Chau; Yannek Leiderman; Mahnaz Shahidi

Tags: biological markers, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, diameter

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5556-5563. doi:https://doi.org/10.1167/iovs.17-21934

Assessment of Neurotrophins and Inflammatory Mediators in Vitreous of Patients With Diabetic Retinopathy Open Access

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Joseph D. Boss; Pawan Kumar Singh; Hemang K. Pandya; Joaquin Tosi; Chaesik Kim; Asheesh Tewari; Mark S. Juzych; Gary W. Abrams; Ashok Kumar

Tags: cytokine, diabetic retinopathy, inflammation mediators, nerve growth factors, vitreous body

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5594-5603. doi:https://doi.org/10.1167/iovs.17-21973

Retinal Cell Biology

Inhibition of Placenta Growth Factor Reduces Subretinal Mononuclear Phagocyte Accumulation in Choroidal Neovascularization Open Access

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Sergio Crespo-Garcia; Caitlin Corkhill; Christophe Roubeix; Anja-Maria Davids; Norbert Kociok; Olaf Strauss; Antonia M. Joussen; Nadine Reichhart

Tags: choroidal neovascularization, lasers, placenta growth factor, inflammation, aflibercept

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 4997-5006. doi:https://doi.org/10.1167/iovs.16-21283

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina Open Access

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Ping Hu; Nicholas H. Hunt; Frank Arfuso; Lynn C. Shaw; Mohammad Nasir Uddin; Meidong Zhu; Raj Devasahayam; Samuel J. Adamson; Vicky L. Benson; Tailoi Chan-Ling; Maria B. Grant

Tags: diabetes mellitus, diabetes mellitus, type 2, microglia, quinine, quinolinic acid

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5043-5055. doi:https://doi.org/10.1167/iovs.17-21654

The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina Open Access

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Sergio Groman-Lupa; Joseph Adewumi; Ko Uoon Park; Joseph A. Brzezinski IV

Tags: ganglia, mice, retina, retinal ganglion cells, transcription factor

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5421-5433. doi:https://doi.org/10.1167/iovs.17-22442

Visual Neuroscience

Mesopic and Photopic Rod and Cone Photoreceptor-Driven Visual Processes in Mice With Long-Wavelength–Shifted Cone Pigments Open Access

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Tina I. Tsai; Anneka Joachimsthaler; Jan Kremers

Tags: luminance, mice, photoreceptors, retinal cone, rod photoreceptors

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5177-5187. doi:https://doi.org/10.1167/iovs.17-22553

Clinical Trials

The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial Open Access

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Kwadwo Owusu Akuffo; Stephen Beatty; Tunde Peto; Jim Stack; Jim Stringham; David Kelly; Irene Leung; Laura Corcoran; John M. Nolan

Tags: age-related macular degeneration, antioxidants, carotenoids, clinical trials, vision

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5347-5360. doi:https://doi.org/10.1167/iovs.16-21192

Review

The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis Open Access

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Dayane Cristine Issaho; Fabio Ramos de Souza Carvalho; Marcia Keiko Uyeno Tabuse; Linda Christian Carrijo-Carvalho; Denise de Freitas

Tags: botulinum toxins, infantile esotropia, injections, meta-analysis, systematic reviews

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5468-5476. doi:https://doi.org/10.1167/iovs.17-22576

Lecture

Introducing Gustavo D. Aguirre, the 2017 Recipient of the Proctor Medal Open Access

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Gerald J. Chader

Tags: awards and prizes

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5396-5398. doi:https://doi.org/10.1167/iovs.17-22937

Concepts and Strategies in Retinal Gene Therapy Open Access

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Gustavo D. Aguirre

Tags: dog, domestic, gene therapy, retinal cone, spatial vectors, photoreceptors

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5399-5411. doi:https://doi.org/10.1167/iovs.17-22978

Letters to the Editor

Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study Open Access

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Xinying Li; Jiawei Wang

Tags: aqueous humor, micrornas, open-angle glaucoma, pilot projects, polymerase chain reaction

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4988. doi:https://doi.org/10.1167/iovs.17-22568

Author Response: Comparison of MicroRNA Expression in Aqueous Humour of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study Open Access

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Hari Jayaram; Diana C. Lozano; Elaine C. Johnson; Tiffany E. Choe; William O. Cepurna; Julie A. Saugstad; John C. Morrison; Kate E. Keller

Tags: aqueous humor, micrornas, open-angle glaucoma, pilot projects, polymerase chain reaction

Investigative Ophthalmology & Visual Science September 2017, Vol.58, 4989. doi:https://doi.org/10.1167/iovs.17-22866

Letter to the Editor: Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas Open Access

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J. William Harbour; Manuel Paez-Escamilla

Tags: tumor size, uveal melanoma

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5444. doi:https://doi.org/10.1167/iovs.17-22603

Index

Reviewers Open Access

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Tags: acetylcholine, achondroplasia, antineutrophil cytoplasmic autoantibody, arthritis, juvenile rheumatoid, betula

Investigative Ophthalmology & Visual Science October 2017, Vol.58, 5007-5014. doi:https://doi.org/10.1167/iovs.17-22936

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