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Research Highlight

A Novel Zebrafish Model for Studying Metastatic Behavior of Human Conjunctival Melanoma Cells Open Access
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Michele C. Madigan
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6072. doi:https://doi.org/10.1167/iovs.17-23347

Anatomy and Pathology/Oncology

Evaluation of (fli:GFP) Casper Zebrafish Embryos as a Model for Human Conjunctival Melanoma Open Access
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Kelly Cristine de Sousa Pontes; Arwin Groenewoud; Jinfeng Cao; Livia Maria Silva Ataide; Ewa Snaar-Jagalska; Martine J. Jager
Tags: embryo, malignant melanoma of conjunctiva, zebrafish, cell lines, vemurafenib
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6065-6071. doi:https://doi.org/10.1167/iovs.17-22023

Biochemistry and Molecular Biology

AAV-CRISPR/Cas9–Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro Open Access
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Wenyi Wu; Yajian Duan; Gaoen Ma; Guohong Zhou; Cindy Park-Windhol; Patricia A. D'Amore; Hetian Lei
Tags: crispr, vascular endothelial growth factor a, vascular endothelial growth factor receptor-2, angiogenesis
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6082-6090. doi:https://doi.org/10.1167/iovs.17-21902

Clinical and Epidemiologic Research

Macular Atrophy Development and Subretinal Drusenoid Deposits in Anti-Vascular Endothelial Growth Factor Treated Age-Related Macular Degeneration Open Access
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Anna V. Zarubina; Orly Gal-Or; Carrie E. Huisingh; Cynthia Owsley; K. Bailey Freund
Tags: age-related macular degeneration, atrophy, digestive tract decontamination, endothelial growth factors, eye
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6038-6045. doi:https://doi.org/10.1167/iovs.17-22378
Tear Levels of Insulin-Like Growth Factor Binding Protein 3 Correlate With Subbasal Nerve Plexus Changes in Patients With Type 2 Diabetes Mellitus Open Access
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Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
Tags: cornea, diabetes mellitus, diabetes mellitus, type 2, insulin-like growth factor binding protein 3, neurons
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6105-6112. doi:https://doi.org/10.1167/iovs.17-22425
Effects of Prenatal Alcohol Exposure on the Visual System of Monkeys Measured at Different Stages of Development Open Access
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Vanessa Harrar; Laurent Elkrief; Joseph Bouskila; Ryan Kucera; Anders Fink-Jensen; Jean-François Bouchard; Roberta Palmour; Maurice Ptito
Tags: cercopithecidae, developmental stages, ethanol, prenatal alcohol exposure, retina
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6282-6291. doi:https://doi.org/10.1167/iovs.17-22181
Skin Intrinsic Fluorescence and Age-Related Macular Degeneration: The Beaver Dam Eye Study Open Access
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Ronald Klein; Kristine E. Lee; John D. Maynard; Stacy M. Meuer; Ronald E. Gangnon; Barbara E. K. Klein
Tags: age-related macular degeneration, eye, fluorescence, serum immunosuppressive factor, human, skin
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6328-6333. doi:https://doi.org/10.1167/iovs.17-22382
Development and Validation of a Risk Score for Age-Related Macular Degeneration: The STARS Questionnaire Open Access
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Cécile Delcourt; Eric Souied; Alice Sanchez; Francesco Bandello; for the STARS Survey Group
Tags: age-related macular degeneration, questionnaires, risk assessment, risk factors, italian
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6399-6407. doi:https://doi.org/10.1167/iovs.17-21819
Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation Open Access
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Mari Holm; Tora S. Morken; Raina N. Fichorova; Deborah K. VanderVeen; Elizabeth N. Allred; Olaf Dammann; Alan Leviton; for the ELGAN Study Neonatology and Ophthalmology Committees
Tags: biological markers, infant, inflammation, proteins, retinopathy of prematurity
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6419-6428. doi:https://doi.org/10.1167/iovs.17-21931

Cornea

CTG18.1 Expansion in TCF4 Among African Americans With Fuchs' Corneal Dystrophy Open Access
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Allen O. Eghrari; Sina Vahedi; Natalie A. Afshari; S. Amer Riazuddin; John D. Gottsch
Tags: african american, hereditary corneal dystrophy, cohort studies, genetics, self-report
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6046-6049. doi:https://doi.org/10.1167/iovs.17-21661
Topical Application of Mizoribine Suppresses CD4+ T-cell–Mediated Pathogenesis in Murine Dry Eye Open Access
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Xiaobo Zhang; Xiang Lin; Zhaolin Liu; Yang Wu; Yiran Yang; Weijie Ouyang; Wei Li; Zuguo Liu
Tags: administration, topical, dry eye syndromes, mice, mizoribine, conjunctiva
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6056-6064. doi:https://doi.org/10.1167/iovs.17-22852
Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes Open Access
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Weibao Xiao; Shuhao Fu; Kang Xu; Ronghua Feng; Fei Sun; Wen Ye
Tags: dry eye syndromes, fingolimod, leukocytes, mice, mice, inbred nod
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6123-6132. doi:https://doi.org/10.1167/iovs.17-21445
Neutrophil and T-Cell Homeostasis in the Closed Eye Open Access
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Cameron K. Postnikoff; Kelly K. Nichols
Tags: eye, neutrophils, t-lymphocytes, homeostasis, sleep
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6212-6220. doi:https://doi.org/10.1167/iovs.17-22449
Designed Host Defense Peptides for the Treatment of Bacterial Keratitis Open Access
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L. Edward Clemens; Jesse Jaynes; Edward Lim; Satya S. Kolar; Rose Y. Reins; Hasna Baidouri; Samuel Hanlon; Alison M. McDermott; Kathryn W. Woodburn
Tags: bacterial keratitis, host defense, keratitis, mice, peptides
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6273-6281. doi:https://doi.org/10.1167/iovs.17-22243
Interface Bonding With Corneal Crosslinking (CXL) After LASIK Ex Vivo Open Access
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Theo G. Seiler; Marleen Engler; Eric Beck; Reginald Birngruber; Irene E. Kochevar
Tags: 5-lipoxygenase-activating protein, cornea, corneal collagen cross-linking, keratomileusis, laser in situ, riboflavin
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6292-6298. doi:https://doi.org/10.1167/iovs.17-22426
Reduced Corneal Nerve Fiber Density in Type 2 Diabetes by Wide-Area Mosaic Analysis Open Access
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Neil S. Lagali; Stephan Allgeier; Pedro Guimarães; Reza A. Badian; Alfredo Ruggeri; Bernd Köhler; Tor Paaske Utheim; Beatrice Peebo; Magnus Peterson; Lars B. Dahlin; Olov Rolandsson
Tags: cornea, diabetes mellitus, type 2, mosaicism, nerve fibers, diabetes mellitus
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6318-6327. doi:https://doi.org/10.1167/iovs.17-22257
Corneal Aberrations in Former Preterm Infants: Results From The Wiesbaden Prematurity Study Open Access
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Achim Fieß; Alexander K. Schuster; Ruth Kölb-Keerl; Markus Knuf; Bernd Kirchhof; Philipp S. Muether; Jacqueline Bauer; for the Prematurity Eye Study Group
Tags: cornea, infant, premature
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6374-6378. doi:https://doi.org/10.1167/iovs.17-22895
Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells Open Access
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Kai B. Kang; Brian D. Lawrence; X. Raymond Gao; Yuncin Luo; Qiang Zhou; Aihong Liu; Victor H. Guaiquil; Mark I. Rosenblatt
Tags: corneal epithelial cells, cytoskeleton, gene expression, genes, microbiology procedures
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6388-6398. doi:https://doi.org/10.1167/iovs.17-22213
TSC1 Mutations in Keratoconus Patients With or Without Tuberous Sclerosis Open Access
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Yelena Bykhovskaya; Majid Fardaei; Mariam Lotfy Khaled; Mahmood Nejabat; Ramin Salouti; Hassan Dastsooz; Yutao Liu; Soroor Inaloo; Yaron S. Rabinowitz
Tags: cornea, genes, keratoconus, mutation, tuberous sclerosis
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6462-6469. doi:https://doi.org/10.1167/iovs.17-22819

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

RNA-Sequencing Gene Expression Profiling of Orbital Adipose-Derived Stem Cell Population Implicate HOX Genes and WNT Signaling Dysregulation in the Pathogenesis of Thyroid-Associated Orbi... Open Access
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Wensi Tao; Juan A. Ayala-Haedo; Matthew G. Field; Daniel Pelaez; Sara T. Wester
Tags: gene expression profiling, genes, graves' ophthalmopathy, pathogenesis, sequence analysis, rna
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6146-6158. doi:https://doi.org/10.1167/iovs.17-22237

Genetics

Rare, Potentially Pathogenic Variants in ZNF469 Are Not Enriched in Keratoconus in a Large Australian Cohort of European Descent Open Access
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Sionne E. M. Lucas; Tiger Zhou; Nicholas B. Blackburn; Richard A. Mills; Jonathan Ellis; Paul Leo; Emmanuelle Souzeau; Bronwyn Ridge; Jac C. Charlesworth; Matthew A. Brown; Richard Lindsay; Jamie E. Craig; Kathryn P. Burdon
Tags: cohort studies, keratoconus, genes
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6248-6256. doi:https://doi.org/10.1167/iovs.17-22417
The Long Noncoding RNA Landscape of the Mouse Eye Open Access
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Weiwei Chen; Shuai Yang; Zhonglou Zhou; Xiaoting Zhao; Jiayun Zhong; Peter S. Reinach; Dongsheng Yan
Tags: body tissue, eye, genes, mice, rna, untranslated
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6308-6317. doi:https://doi.org/10.1167/iovs.17-22178
Novel Mutations in PRPF31 Causing Retinitis Pigmentosa Identified Using Whole-Exome Sequencing Open Access
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Xiaoqiang Xiao; Yingjie Cao; Zhun Zhang; Yanxuan Xu; Yuqian Zheng; Li Jia Chen; Chi Pui Pang; Haoyu Chen
Tags: mutation, retinitis pigmentosa, whole exome sequencing, family, proteins
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6342-6350. doi:https://doi.org/10.1167/iovs.17-22952
Mitochondrial Haplogroups Modify the Effect of Diabetes Duration and HbA1c on Proliferative Diabetic Retinopathy Risk in Patients With Type 2 Diabetes Open Access
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Sabrina L. Mitchell; Abigail C. Neininger; Carleigh N. Bruce; Isaac M. Chocron; Jana A. Bregman; Christopher B. Estopinal; Ayesha Muhammad; Allison C. Umfress; Kelli L. Jarrell; Cassandra Warden; Paula A. Harlow; Melissa Wellons; David C. Samuels; Milam A. Brantley, Jr
Tags: diabetes mellitus, type 2, hemoglobin a, glycosylated, mitochondria, proliferative diabetic retinopathy, risk factors
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6481-6488. doi:https://doi.org/10.1167/iovs.17-22804
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy Open Access
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Shu-Jie Zhang; Xue Chen; Chao-Peng Li; Xiu-Miao Li; Chang Liu; Bai-Hui Liu; Kun Shan; Qin Jiang; Chen Zhao; Biao Yan
Tags: biological markers, diabetes mellitus, micrornas, retinal diseases, rna
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6500-6509. doi:https://doi.org/10.1167/iovs.17-22698

Glaucoma

AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury Open Access
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Robert W. Nickells; Heather M. Schmitt; Margaret E. Maes; Cassandra L. Schlamp
Tags: mice, optic nerve, optic nerve injuries, retina, eye
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6091-6104. doi:https://doi.org/10.1167/iovs.17-22634
Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model Open Access
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Ke Zhu; Meng-Lu Zhang; Shu-Ting Liu; Xue-Yan Li; Shu-Min Zhong; Fang Li; Ge-Zhi Xu; Zhongfeng Wang; Yanying Miao
Tags: apoptosis, autophagy, ghrelin, glaucoma, retina
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6113-6122. doi:https://doi.org/10.1167/iovs.17-22465
Tissue Transglutaminase Elevates Intraocular Pressure in Mice Open Access
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Urmimala Raychaudhuri; J. Cameron Millar; Abbot F. Clark
Tags: body tissue, eye, intraocular pressure, mice, transglutaminases
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6197-6211. doi:https://doi.org/10.1167/iovs.17-22236
The Magnitude and Time Course of IOP Change in Response to Body Position Change in Nonhuman Primates Measured Using Continuous IOP Telemetry Open Access
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Daniel C. Turner; Brian C. Samuels; Carrie Huisingh; Christopher A. Girkin; J. Crawford Downs
Tags: intraocular pressure, telemetry, time factors, eye, primates
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6232-6240. doi:https://doi.org/10.1167/iovs.17-22858
Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric Glaucoma? Open Access
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Won June Lee; Young Kook Kim; Jin Wook Jeoung; Ki Ho Park
Tags: glaucoma, maps, optical coherence tomography, visual fields, eye
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6257-6264. doi:https://doi.org/10.1167/iovs.17-22697
Evaluation of Retinal Nerve Fiber Layer Thinning in Myopic Glaucoma: Impact of Optic Disc Morphology Open Access
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Kyeong Ik Na; Won June Lee; Young Kook Kim; Ki Ho Park; Jin Wook Jeoung
Tags: glaucoma, musculoskeletal torsion, function, optic disk, retinal nerve fiber layer, torsion
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6265-6272. doi:https://doi.org/10.1167/iovs.17-22534
Evaluation of Ganglion Cell–Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis Open Access
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Won June Lee; Young Kook Kim; Ki Ho Park; Jin Wook Jeoung
Tags: eye, ganglia, glaucoma, hemorrhage, optic disk
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6449-6456. doi:https://doi.org/10.1167/iovs.17-22547

Immunology and Microbiology

The Influence of Age and Sex on Ocular Surface Microbiota in Healthy Adults Open Access
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Xiaofeng Wen; Li Miao; Yuhua Deng; Paul W. Bible; Xiao Hu; Yanli Zou; Yu Liu; Shixin Guo; Juanran Liang; Tingting Chen; Guang-Hua Peng; Wei Chen; Lingyi Liang; Lai Wei
Tags: adult, conjunctiva, microbiome
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6030-6037. doi:https://doi.org/10.1167/iovs.17-22957

Lens

Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins Open Access
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Sindhu Kumari; Junyuan Gao; Richard T. Mathias; Xiurong Sun; Amizhdini Eswaramoorthy; Nicholas Browne; Nigel Zhang; Kulandaiappan Varadaraj
Tags: lens (device), lens, crystalline, proteins
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6006-6019. doi:https://doi.org/10.1167/iovs.17-22153
Effect of Age-Related Human Lens Sutures Growth on Its Fluid Dynamics Open Access
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Ho-Ting D. Wu; Louisa A. Howse; Ehsan Vaghefi
Tags: fluid dynamics, lens, crystalline, microcirculation, sutures, lens (device)
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6351-6357. doi:https://doi.org/10.1167/iovs.17-22099
The Intraocular Lens as a Drug Delivery Device: In Vitro Screening of Pharmacologic Substances for the Prophylaxis of Posterior Capsule Opacification Open Access
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Christian Wertheimer; Stefan Kassumeh; Nick P. Piravej; Olga Nilmayer; Christian Braun; Claudia Priglinger; Nikolaus Luft; Armin Wolf; Wolfgang J. Mayer; Siegfried G. Priglinger; Kirsten H. Eibl-Lindner
Tags: after-cataract, drug delivery systems, intraocular lens implant device, methotrexate, pharmacology
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6408-6418. doi:https://doi.org/10.1167/iovs.17-22555
Intraocular Pressure Course During the Femtosecond Laser-Assisted Cataract Surgery in Porcine Cadaver Eyes Open Access
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Philipp Sperl; Clemens Strohmaier; Hannes Kraker; Karolina Motloch; Markus Lenzhofer; Sarah Moussa; Herbert A. Reitsamer
Tags: cadaver, cataract surgery, eye, intraocular pressure, lasers
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6457-6461. doi:https://doi.org/10.1167/iovs.17-21948

Low Vision

The Preferred Retinal Locus Used to Watch Videos Open Access
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Francisco M. Costela; Sidika Kajtezovic; Russell L. Woods
Tags: gaze, vision
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6073-6081. doi:https://doi.org/10.1167/iovs.17-21839
Diabetic Retinopathy and Macular Edema Quality-of-Life Item Banks: Development and Initial Evaluation Using Computerized Adaptive Testing Open Access
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Eva K. Fenwick; Jyoti Khadka; Konrad Pesudovs; Gwyn Rees; Tien Y. Wong; Ecosse L. Lamoureux
Tags: adaptive testing, diabetic retinopathy, macular edema, patient evaluation, precision
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6379-6387. doi:https://doi.org/10.1167/iovs.16-20950

Physiology and Pharmacology

Coefficient of Friction Between Carboxymethylated Hyaluronic Acid-Based Polymer Films and the Ocular Surface Open Access
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Jourdan Colter; Barbara Wirostko; Brittany Coats
Tags: eye, friction, polymers
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6166-6174. doi:https://doi.org/10.1167/iovs.17-22414
PI3K/Akt Pathway: A Role in δ-Opioid Receptor–Mediated RGC Neuroprotection Open Access
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Shahid Husain; Anis Ahmad; Sudha Singh; Carolyn Peterseim; Yasir Abdul; Matthew J. Nutaitis
Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, glaucoma, neuroprotection, ocular hypertension
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6489-6499. doi:https://doi.org/10.1167/iovs.16-20673

Retina

Parafoveal Photoreceptor Abnormalities in Asymptomatic Patients With RP1L1 Mutations in Families With Occult Macular Dystrophy Open Access
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Yu Kato; Gen Hanazono; Kaoru Fujinami; Tetsuhisa Hatase; Yuichi Kawamura; Takeshi Iwata; Yozo Miyake; Kazushige Tsunoda
Tags: family, macular dystrophy, mutation, parafoveal region, photoreceptors
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6020-6029. doi:https://doi.org/10.1167/iovs.17-21969
Effect of Gravity Acceleration on Choroidal and Retinal Nerve Fiber Layer Thickness: A Swept-Source Optical Coherence Tomography Study Open Access
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Dong Yoon Kim; Jiho Song; Jin Young Kim; Kyungpil Choi; Sungmin Hyung; Ju Byung Chae
Tags: centrifuges, force of gravity, optical coherence tomography, retinal nerve fiber layer, training
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6050-6055. doi:https://doi.org/10.1167/iovs.17-21994
Quantitative Fundus Autofluorescence in Pseudoxanthoma Elasticum Open Access
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Martin Gliem; Philipp L. Müller; Johannes Birtel; Myra B. McGuinness; Robert P. Finger; Philipp Herrmann; Doris Hendig; Frank G. Holz; Peter Charbel Issa
Tags: bruch's basal membrane, calcification, fundus autofluorescence imaging, pseudoxanthoma elasticum, lipofuscin
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6159-6165. doi:https://doi.org/10.1167/iovs.17-22007
Retinal Reflectivity Measurement for Cone Impairment Estimation and Visual Assessment After Diabetic Macular Edema Resolution (RECOVER-DME) Open Access
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Benjamin Guyon; Emeric Elphege; Mathieu Flores; Anne-Sophie Gauthier; Bernard Delbosc; Maher Saleh
Tags: diabetic macular edema, impairment, retinal cone, diabetes mellitus, eye
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6241-6247. doi:https://doi.org/10.1167/iovs.17-22380
Platelet-Derived Growth Factor-BB Lessens Light-Induced Rod Photoreceptor Damage in Mice Open Access
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Kei Takahashi; Masamitsu Shimazawa; Hiroshi Izawa; Yuki Inoue; Yoshiki Kuse; Hideaki Hara
Tags: mice, platelet-derived growth factor, platelet-derived growth factor receptor, rod photoreceptors, light exposure
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6299-6307. doi:https://doi.org/10.1167/iovs.17-22556
Changes in Relative Position of Choroidal Versus Retinal Vessels in Preterm Infants Open Access
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Sang Jin Kim; J. Peter Campbell; Susan Ostmo; Karyn E. Jonas; R. V. Paul Chan; Michael F. Chiang; for the Imaging and Informatics in Retinopathy of Prematurity (i-ROP) Research Consortium
Tags: cohort studies, eye, infant, premature, retinal vessels
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6334-6341. doi:https://doi.org/10.1167/iovs.17-22687
Patchy Chorioretinal Atrophy Changes at the Posterior Pole After Ranibizumab for Myopic Choroidal Neovascularization Open Access
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Mariacristina Parravano; Fabio Scarinci; Marta Gilardi; Lea Querques; Monica Varano; Francesco Oddone; Francesco Bandello; Giuseppe Querques
Tags: atrophy, choroidal neovascularization, eye, ranibizumab, follow-up
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6358-6364. doi:https://doi.org/10.1167/iovs.17-22633
Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy Open Access
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Sangeetha Srinivasan; Cirous Dehghani; Nicola Pritchard; Katie Edwards; Anthony W. Russell; Rayaz A. Malik; Nathan Efron
Tags: cornea, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, tissue degeneration
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6365-6373. doi:https://doi.org/10.1167/iovs.17-22736
Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors Open Access
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Christopher A. Reid; Kristina J. Ertel; Daniel M. Lipinski
Tags: capsid, mice, photoreceptors, retina, spatial vectors
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6429-6439. doi:https://doi.org/10.1167/iovs.17-22281

Retinal Cell Biology

Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes Open Access
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Arul J. Duraisamy; Manish Mishra; Renu A. Kowluru
Tags: diabetes mellitus, diabetes mellitus, type 2, dna methylation, ezh2 gene, gelatinase b
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6440-6448. doi:https://doi.org/10.1167/iovs.17-22706

Visual Neuroscience

Transretinal ERG in Studying Mouse Rod Phototransduction: Comparison With Local ERG Across the Rod Outer Segments Open Access
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Teemu T. Turunen; Ari Koskelainen
Tags: electroretinography, mice, phototransduction, rod outer segments, rod photoreceptors
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6133-6145. doi:https://doi.org/10.1167/iovs.17-22248

Visual Psychophysics and Physiological Optics

Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults Open Access
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Lillian Chien; Rong Liu; Christopher Girkin; MiYoung Kwon
Tags: glaucoma, older adult
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6221-6231. doi:https://doi.org/10.1167/iovs.17-22621
Unstable Binocular Fixation Affects Reaction Times But Not Implicit Motor Learning in Dyslexia Open Access
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Anna Przekoracka-Krawczyk; Alicja Brenk-Krakowska; Paweł Nawrot; Patrycja Rusiak; Ryszard Naskręcki
Tags: dyslexia, motor learning, reaction time
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6470-6480. doi:https://doi.org/10.1167/iovs.16-21305

Review

Animal Models of Retinal Vein Occlusion Open Access
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Meiaad Khayat; Noemi Lois; Michael Williams; Alan W. Stitt
Tags: animal model, lasers, light coagulation, macular edema, retinal vein occlusion
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6175-6192. doi:https://doi.org/10.1167/iovs.17-22788

Lecture

Introducing Johanna M. Seddon, the 2017 Recipient of the Mildred Weisenfeld Award Open Access
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Martine J. Jager
Tags: awards and prizes, macular degeneration
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6510-6512. doi:https://doi.org/10.1167/iovs.17-23542
Macular Degeneration Epidemiology: Nature-Nurture, Lifestyle Factors, Genetic Risk, and Gene-Environment Interactions – The Weisenfeld Award Lecture Open Access
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Johanna M. Seddon
Tags: awards and prizes, epidemiology, gene-environment interaction, genes, genetic risk
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6513-6528. doi:https://doi.org/10.1167/iovs.17-23544

Letters to the Editor

Intraretinal Correlates of Reticular Pseudodrusen Revealed by Autofluorescence and En Face OCT Open Access
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Riccardo Sacconi; Giuseppe Querques
Tags: autofluorescence, face
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6193. doi:https://doi.org/10.1167/iovs.17-23166
Author Response: Intraretinal Correlates of Reticular Pseudodrusen Revealed by Autofluorescence and En Face OCT Open Access
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Janet R. Sparrow; Maarjallis Paavo
Tags: autofluorescence, face
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6194. doi:https://doi.org/10.1167/iovs.17-23215
The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy Open Access
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Alessandro Marchese; Giuseppe Querques
Tags: atrophy, optical coherence tomography
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6195. doi:https://doi.org/10.1167/iovs.17-23072
Author Response: The Evolution of the Plateau, an Optical Coherence Tomography Signature Seen in Geographic Atrophy Open Access
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Anna C. S. Tan; Kunal K. Dansingani; Christine A. Curcio; K. Bailey Freund
Tags: atrophy, optical coherence tomography
Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6196. doi:https://doi.org/10.1167/iovs.17-23339

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science December 2017, Vol.58, 6529. doi:https://doi.org/10.1167/iovs.17-21902a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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