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Research Highlight

Fixation Instability: A New Measure of Neurologic Dysfunction in Multiple Sclerosis Open Access
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Prem S. Subramanian
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 202. doi:https://doi.org/10.1167/iovs.17-23603
The Suprachoroidal Delivery Route and Exploring the Potential of Cell-Based Therapies for Age-Related Macular Degeneration Open Access
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Timothy W. Olsen
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 321. doi:https://doi.org/10.1167/iovs.17-23605

Anatomy and Pathology/Oncology

BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi Open Access
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Jasmine H. Francis; Hans E. Grossniklaus; Larissa A. Habib; Brian Marr; David H. Abramson; Klaus J. Busam
Tags: braf gene, conjunctiva, melanocytic nevus, mutation, nevus of conjunctiva
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 117-121. doi:https://doi.org/10.1167/iovs.17-22517
ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells Open Access
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Salma Kaochar; Jianrong Dong; Marie Torres; Kimal Rajapakshe; Fotis Nikolos; Christel M. Davis; Erik A. Ehli; Cristian Coarfa; Nicholas Mitsiades; Vasiliki Poulaki
Tags: genes, uveal melanoma, neoplasm metastasis, cell lines, cell cycle
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 132-143. doi:https://doi.org/10.1167/iovs.17-22454
Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma Open Access
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Anthony B. Daniels; Michael T. Froehler; Janene M. Pierce; Amy H. Nunnally; M. Wade Calcutt; Thomas M. Bridges; David C. LaNeve; Phillip E. Williams; Kelli L. Boyd; Michelle L. Reyzer; Craig W. Lindsley; Debra L. Friedman; Ann Richmond
Tags: body tissue, chemotherapy regimen, melphalan, oryctolagus cuniculus, pharmacokinetics
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 446-454. doi:https://doi.org/10.1167/iovs.17-22302
The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques Open Access
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Li-Fang Hung; Baskar Arumugam; Lisa Ostrin; Nimesh Patel; Klaus Trier; Monica Jong; Earl L. Smith III
Tags: adenosine receptor antagonists, cercopithecidae, eye, infant, lens (device)
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 472-486. doi:https://doi.org/10.1167/iovs.17-22337

Biochemistry and Molecular Biology

Molecular Defects of the Disease-Causing Human Arrestin-1 C147F Mutant Open Access
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Sergey A. Vishnivetskiy; Lori S. Sullivan; Sara J. Bowne; Stephen P. Daiger; Eugenia V. Gurevich; Vsevolod V. Gurevich
Tags: arrestin, proteins
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 13-20. doi:https://doi.org/10.1167/iovs.17-22180
Amelioration of Endotoxin-Induced Inflammatory Toxic Response by a Metal Chelator in Rat Eyes Open Access
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Mohammad Shoeb; Min Zhang; Tianlin Xiao; Misha F. Syed; Naseem H. Ansari
Tags: aqueous humor, chelating agents, endotoxins, eye, eye inflammation
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 31-38. doi:https://doi.org/10.1167/iovs.17-22172
Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration Open Access
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Nathaniel F. Henneman; Stephanie L. Foster; Micah A. Chrenek; Jana T. Sellers; Charles B. Wright; Robin H. Schmidt; John M. Nickerson; Jeffrey H. Boatright
Tags: language morphology, mice, morphology, retina, retinal degeneration
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 45-53. doi:https://doi.org/10.1167/iovs.17-22132
A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders Open Access
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Cinzia Bocca; Judith Kouassi Nzoughet; Stéphanie Leruez; Patrizia Amati-Bonneau; Marc Ferré; Mariame-Selma Kane; Charlotte Veyrat-Durebex; Juan Manuel Chao de la Barca; Arnaud Chevrollier; Chadi Homedan; Christophe Verny; Dan Miléa; Vincent Procaccio; Gilles Simard; Dominique Bonneau; Guy Lenaers; Pascal Reynier
Tags: metabolites, metabolomics, optic atrophy, autosomal dominant, plasma, purine metabolism pathway
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 185-195. doi:https://doi.org/10.1167/iovs.17-23027
Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures Open Access
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Janice A. Vranka; Julia A. Staverosky; Ashok P. Reddy; Phillip A. Wilmarth; Larry L. David; Ted S. Acott; Paul Russell; Vijay Krishna Raghunathan
Tags: biomechanics, body tissue, fluid flow, heart failure, muscle rigidity
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 246-259. doi:https://doi.org/10.1167/iovs.17-22759

Clinical and Epidemiologic Research

Risk of Retinal Vein Occlusion in Patients With End-Stage Renal Disease: A 12-Year, Retrospective, Nationwide Cohort Study in South Korea Open Access
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Kyung Sik Lee; Ki Heon Nam; Dong Wook Kim; Eui Chun Kang; Hyoung Jun Koh
Tags: cohort studies, kidney failure, chronic, retinal vein occlusion, retrospective studies, south korea
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 39-44. doi:https://doi.org/10.1167/iovs.17-22638
Severe Loss of Tritan Color Discrimination in RPE65 Associated Leber Congenital Amaurosis Open Access
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Neruban Kumaran; Caterina Ripamonti; Angelos Kalitzeos; Gary S. Rubin; James W. B. Bainbridge; Michel Michaelides
Tags: color, color vision, leber's amaurosis
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 85-93. doi:https://doi.org/10.1167/iovs.17-22905
Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration Open Access
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Atalie C. Thompson; Ulrich F. O. Luhmann; Sandra S. Stinnett; Lejla Vajzovic; Anupama Horne; Cynthia A. Toth; Scott W. Cousins; Eleonora M. Lad
Tags: age-related macular degeneration, functional measures, luminance, questionnaires, eye
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 289-297. doi:https://doi.org/10.1167/iovs.17-22528

Cornea

Aspergillus fumigatus Increased PAR-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of PAR-2/ERK1/2 in Cornea Open Access
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Yawen Niu; Guiqiu Zhao; Cui Li; Jing Lin; Nan Jiang; Chengye Che; Jie Zhang; Qiang Xu
Tags: aspergillus fumigatus, cornea, cytokine, keratitis, proteins
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 166-175. doi:https://doi.org/10.1167/iovs.17-21887
Assessment of Human Corneas Prior to Transplantation Using High-Resolution Two-Photon Imaging Open Access
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Ana Batista; Hans Georg Breunig; Aisada König; Andreas Schindele; Tobias Hager; Berthold Seitz; António Miguel Morgado; Karsten König
Tags: cornea, diagnostic imaging, photons, transplantation, collagen
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 176-184. doi:https://doi.org/10.1167/iovs.17-22002
Colocalization of Galectin-3 With CD147 Is Associated With Increased Gelatinolytic Activity in Ulcerating Human Corneas Open Access
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Andrea Cruzat; Miguel Gonzalez-Andrades; Jérôme Mauris; Dina B. AbuSamra; Preethi Chidambaram; Kenneth R. Kenyon; James Chodosh; Claes H. Dohlman; Pablo Argüeso
Tags: cornea, corneal ulcer, galectin 3, ulcer
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 223-230. doi:https://doi.org/10.1167/iovs.17-23196
Pain Sensitivity Associated With the Length of the Maximum Interblink Period Open Access
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Wing Li; Meng C. Lin
Tags: dysmenorrhea, pain threshold, dry eye syndromes
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 238-245. doi:https://doi.org/10.1167/iovs.17-22950
Identifying Corneal Infections in Formalin-Fixed Specimens Using Next Generation Sequencing Open Access
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Zhigang Li; Florian P. Breitwieser; Jennifer Lu; Albert S. Jun; Laura Asnaghi; Steven L. Salzberg; Charles G. Eberhart
Tags: corneal infections, formaldehyde, keratitis, massively-parallel genome sequencing, pathogenic organism
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 280-288. doi:https://doi.org/10.1167/iovs.17-21617
Antimicrobial Studies Using the Therapeutic Tissue Cross-Linking Agent, Sodium Hydroxymethylglycinate: Implication for Treating Infectious Keratitis Open Access
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Patrick B. Rapuano; Alexandra H. Scanameo; Daeryl E. Amponin; Sefy A. Paulose; Mariya Zyablitskaya; Anna Takaoka; Leejee H. Suh; Takayuki Nagasaki; Stephen L. Trokel; David C. Paik
Tags: antimicrobials, body tissue, cross-linking, keratitis, sodium
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 332-337. doi:https://doi.org/10.1167/iovs.17-23111
Long Term Temporal Changes in Structure and Function of Rat Visual System After Blast Exposure Open Access
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Daniel F. Shedd; Nikolaus A. Benko; Justin Jones; Brian E. Zaugg; Robert L. Peiffer; Brittany Coats
Tags: basic local alignment search tool, eye, cornea, visual system, contrast sensitivity
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 349-361. doi:https://doi.org/10.1167/iovs.17-21530
EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling Open Access
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Nihal Kaplan; Rosa Ventrella; Han Peng; Sonali Pal-Ghosh; Constadina Arvanitis; Joshua Z. Rappoport; Brian J. Mitchell; Mary Ann Stepp; Robert M. Lavker; Spiro Getsios
Tags: corneal epithelial cells, ephrins, signal transduction, corneal epithelium, epidermal growth factor receptors
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 393-406. doi:https://doi.org/10.1167/iovs.17-22941
A Novel C-Terminal Mutation in Gsdma3 (C+/H−) Leads to Alopecia and Corneal Inflammatory Response in Mice Open Access
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Sebastian Swirski; Carsten Röger; Aldona Pieńkowska-Schelling; Cynthia Ihlenburg; Gösta Fischer; Oliver May; Mariann Vorm; Marta Owczarek-Lipska; John Neidhardt
Tags: alopecia, cornea, mice, mutation, meibomian gland
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 561-571. doi:https://doi.org/10.1167/iovs.17-22658

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Visual Fixation Instability in Multiple Sclerosis Measured Using SLO-OCT Open Access
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Robert M. Mallery; Pieter Poolman; Matthew J. Thurtell; Jan M. Full; Johannes Ledolter; Dorlan Kimbrough; Elliot M. Frohman; Teresa C. Frohman; Randy H. Kardon
Tags: multiple sclerosis, ocular fixation, scanning laser ophthalmoscopy, eye, volume
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 196-201. doi:https://doi.org/10.1167/iovs.17-22391
Composition, Architecture, and Functional Implications of the Connective Tissue Network of the Extraocular Muscles Open Access
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Linda K. McLoon; André Vicente; Krysta R. Fitzpatrick; Mona Lindström; Fatima Pedrosa Domellöf
Tags: connective tissue, muscle, muscle of orbit, epimysium
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 322-329. doi:https://doi.org/10.1167/iovs.17-23003
A Novel Type of Multiterminal Motor Endplate in Human Extraocular Muscles Open Access
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Jing-Xia Liu; Fatima Pedrosa Domellöf
Tags: cholinergic receptors, motor endplate, adult, antibodies, fetus
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 539-548. doi:https://doi.org/10.1167/iovs.17-22554

Genetics

Novel Myopia Genes and Pathways Identified From Syndromic Forms of Myopia Open Access
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D. Ian Flitcroft; James Loughman; Christine F. Wildsoet; Cathy Williams; Jeremy A. Guggenheim; for the CREAM Consortium
Tags: cream, genes, genome-wide association study, myopia, refractive errors
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 338-348. doi:https://doi.org/10.1167/iovs.17-22173

Glaucoma

Role of the Autotaxin-LPA Pathway in Dexamethasone-Induced Fibrotic Responses and Extracellular Matrix Production in Human Trabecular Meshwork Cells Open Access
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Megumi Honjo; Nozomi Igarashi; Junko Nishida; Makoto Kurano; Yutaka Yatomi; Koji Igarashi; Kuniyuki Kano; Junken Aoki; Makoto Aihara
Tags: dexamethasone, extracellular matrix, glaucoma, trabecular meshwork, cytoskeleton
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 21-30. doi:https://doi.org/10.1167/iovs.17-22807
A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head Open Access
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Sripad Krishna Devalla; Khai Sing Chin; Jean-Martial Mari; Tin A. Tun; Nicholas G. Strouthidis; Tin Aung; Alexandre H. Thiéry; Michaël J. A. Girard
Tags: body tissue, learning, optic disk, optical coherence tomography, training
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 63-74. doi:https://doi.org/10.1167/iovs.17-22617
Autofluorescence of Skin Advanced Glycation End Products as a Risk Factor for Open Angle Glaucoma: The ALIENOR Study Open Access
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Cedric Schweitzer; Audrey Cougnard-Gregoire; Vincent Rigalleau; Jean-Francois Dartigues; Florence Malet; Marie-Benedicte Rougier; Marie-Noelle Delyfer; Catherine Helmer; Jean-Francois Korobelnik; Cecile Delcourt
Tags: glaucoma, skin, autofluorescence, risk factors, open-angle glaucoma
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 75-84. doi:https://doi.org/10.1167/iovs.17-22316
Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent Open Access
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Tomoko Kirihara; Takazumi Taniguchi; Kenzo Yamamura; Ryo Iwamura; Kenji Yoneda; Noriko Odani-Kawabata; Atsushi Shimazaki; Takeshi Matsugi; Naveed Shams; Jin-Zhong Zhang
Tags: agonists, antihypertensive agents, intraocular pressure, pharmacology, prostaglandins
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 145-153. doi:https://doi.org/10.1167/iovs.17-22745
Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics Open Access
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Yi Hua; Andrew P. Voorhees; Ian A. Sigal
Tags: biomechanics, cerebrospinal fluid pressure, optic disk, intraocular pressure, sclera
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 154-165. doi:https://doi.org/10.1167/iovs.17-22488
In Vivo Three-Dimensional Lamina Cribrosa Strains in Healthy, Ocular Hypertensive, and Glaucoma Eyes Following Acute Intraocular Pressure Elevation Open Access
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Meghna R. Beotra; Xiaofei Wang; Tin A. Tun; Liang Zhang; Mani Baskaran; Tin Aung; Nicholas G. Strouthidis; Michaël J. A. Girard
Tags: eye, glaucoma, intraocular pressure, ocular hypertension, cribriform plate
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 260-272. doi:https://doi.org/10.1167/iovs.17-21982
Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork Open Access
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Zeynep Aktas; Hongyu Rao; Sarah R. Slauson; B'Ann T. Gabelt; Inna V. Larsen; Rachael T. C. Sheridan; Leonie Herrnberger; Ernst R. Tamm; Paul L. Kaufman; Curtis R. Brandt
Tags: dimethyl sulfoxide, feline immunodeficiency virus, genes, multicatalytic endopeptidase complex, spatial vectors
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 298-310. doi:https://doi.org/10.1167/iovs.17-22074
Early Gene Expression Profile in Retinal Ganglion Cell Layer After Optic Nerve Crush in Mice Open Access
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Satoru Ueno; Azusa Yoneshige; Yoshiki Koriyama; Man Hagiyama; Yoshikazu Shimomura; Akihiko Ito
Tags: gene expression, gene expression profiling, genes, glaucoma, mice
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 370-380. doi:https://doi.org/10.1167/iovs.17-22438
Changes in Axial Length and Progression of Visual Field Damage in Glaucoma Open Access
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Mieko Yanagisawa; Takehiro Yamashita; Masato Matsuura; Yuri Fujino; Hiroshi Murata; Ryo Asaoka
Tags: eye, glaucoma, intraocular pressure, maximum tolerated dose, visual fields
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 407-417. doi:https://doi.org/10.1167/iovs.17-22949
The Effective Dynamic Ranges for Glaucomatous Visual Field Progression With Standard Automated Perimetry and Stimulus Sizes III and V Open Access
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Michael Wall; Gideon K. D. Zamba; Paul H. Artes
Tags: dynamic range, glaucoma, linear regression, perimetry, visual fields
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 439-445. doi:https://doi.org/10.1167/iovs.17-22390

Immunology and Microbiology

Temporal Expression of Genes in Biofilm-Forming Ocular Candida albicans Isolated From Patients With Keratitis and Orbital Cellulitis Open Access
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Konduri Ranjith; Sama Kalyana Chakravarthy; HariKrishna Adicherla; Savitri Sharma; Sisinthy Shivaji
Tags: biofilms, genes, keratitis, antifungal agents
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 528-538. doi:https://doi.org/10.1167/iovs.17-22933
Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR Open Access
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Paulo J. M. Bispo; Samaneh Davoudi; Matthew L. Sahm; Ai Ren; John Miller; John Romano; Lucia Sobrin; Michael S. Gilmore
Tags: molecular diagnostic techniques, pathogenic organism, polymerase chain reaction, uveitis, dna
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 582-589. doi:https://doi.org/10.1167/iovs.17-22597

Lens

Proteome Profiling of Developing Murine Lens Through Mass Spectrometry Open Access
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Shahid Y. Khan; Muhammad Ali; Firoz Kabir; Santosh Renuse; Chan Hyun Na; C. Conover Talbot, Jr; Sean F. Hackett; S. Amer Riazuddin
Tags: lens (device), lens, crystalline, mass spectrometry, mice, proteins
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 100-107. doi:https://doi.org/10.1167/iovs.17-21601

Low Vision

Effects of Age-Related Macular Degeneration on Driving Performance Open Access
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Joanne M. Wood; Alex A. Black; Kerry Mallon; Anthony S. Kwan; Cynthia Owsley
Tags: age-related macular degeneration, visual acuity, motion, contrast sensitivity, visual fields
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 273-279. doi:https://doi.org/10.1167/iovs.17-22751

Multidisciplinary Ophthalmic Imaging

Pattern Onset ERGs and VEPs Produced by Patterns Arising From Light Increment and Decrement Open Access
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Dennis M. Fritsch; Jane C. Sowden; Dorothy A. Thompson
Tags: evoked potentials, visual
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 94-99. doi:https://doi.org/10.1167/iovs.17-22984
In Vivo Elasticity Mapping of Posterior Ocular Layers Using Acoustic Radiation Force Optical Coherence Elastography Open Access
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Yueqiao Qu; Youmin He; Arya Saidi; Yihang Xin; Yongxiao Zhou; Jiang Zhu; Teng Ma; Ronald H. Silverman; Don S. Minckler; Qifa Zhou; Zhongping Chen
Tags: acoustics, diagnostic imaging, elasticity, elasticity imaging techniques, optics
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 455-461. doi:https://doi.org/10.1167/iovs.17-22971
Retinal Lesion Detection With Deep Learning Using Image Patches Open Access
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Carson Lam; Caroline Yu; Laura Huang; Daniel Rubin
Tags: datasets, exudates, learning, microaneurysm, pixel
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 590-596. doi:https://doi.org/10.1167/iovs.17-22721

Physiology and Pharmacology

Novel Insight Into the Role of CFTR in Lacrimal Gland Duct Function in Mice Open Access
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Orsolya Berczeli; Eszter Vizvári; Máté Katona; Dénes Török; László Szalay; Ferenc Rárosi; István Németh; Zoltán Rakonczay; Péter Hegyi; Chuanqing Ding; Edit Tóth-Molnár
Tags: bodily secretions, cystic fibrosis transmembrane conductance regulator, mice, lacrimal gland, carbachol
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 54-62. doi:https://doi.org/10.1167/iovs.17-22533
Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice Open Access
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Guorong Li; Karen Y. Torrejon; Andrea M. Unser; Feryan Ahmed; Iris D. Navarro; Rudolf A. Baumgartner; David S. Albers; W. Daniel Stamer
Tags: adenosine, eye, intraocular pressure, mice, gelatinase a
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 383-392. doi:https://doi.org/10.1167/iovs.17-23212

Retina

Quantitative Study of the Macular Microvasculature in Human Donor Eyes Open Access
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Paula K. Yu; Zaid Mammo; Chandrakumar Balaratnasingam; Dao-Yi Yu
Tags: donors, eye, macula lutea, microvascular network, quantitative research
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 108-116. doi:https://doi.org/10.1167/iovs.17-22542
A Novel Strategy for Quantifying Choriocapillaris Flow Voids Using Swept-Source OCT Angiography Open Access
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Qinqin Zhang; Fang Zheng; Elie H. Motulsky; Giovanni Gregori; Zhongdi Chu; Chieh-Li Chen; Chunxia Li; Luis de Sisternes; Mary Durbin; Philip J. Rosenfeld; Ruikang K. Wang
Tags: angiogram, drusen, fluid flow, eye, diagnostic imaging
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 203-211. doi:https://doi.org/10.1167/iovs.17-22953
Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography? Open Access
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Alessandro Rabiolo; Francesco Gelormini; Alessandro Marchese; Maria Vittoria Cicinelli; Giacinto Triolo; Riccardo Sacconi; Lea Querques; Francesco Bandello; Giuseppe Querques
Tags: angiogram, optical coherence tomography, perfusion, interrater reliability, blood capillaries
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 231-237. doi:https://doi.org/10.1167/iovs.17-22359
A Subretinal Cell Delivery Method via Suprachoroidal Access in Minipigs: Safety and Surgical Outcomes Open Access
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Marc D. de Smet; Jessica L. Lynch; Nadine S. Dejneka; Michael Keane; I. John Khan
Tags: blister, eye, injections, safety, surgical outcome
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 311-320. doi:https://doi.org/10.1167/iovs.17-22233
Quantification of Macular Microvascular Changes in Patients With Retinitis Pigmentosa Using Optical Coherence Tomography Angiography Open Access
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Daiki Inooka; Shinji Ueno; Taro Kominami; Akira Sayo; Satoshi Okado; Yasuki Ito; Hiroko Terasaki
Tags: angiogram, eye, optical coherence tomography, retina, retinitis pigmentosa
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 433-438. doi:https://doi.org/10.1167/iovs.17-23202
The Role of ERK1/2 Activation in Sarpogrelate-Mediated Neuroprotection Open Access
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Cristy A. Ku; Renee C. Ryals; Dan Jiang; Aaron S. Coyner; Kyle K. Weller; Wrik Sinha; Bryan M. Robb; Paul Yang; Mark E. Pennesi
Tags: mitogen-activated protein kinases, neuroprotection, phosphorylation, proteins, extracellular matrix-cell signaling
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 462-471. doi:https://doi.org/10.1167/iovs.17-23159
Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease Open Access
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Michael D. Abramoff; Patrice E. Fort; Ian C. Han; K. Thiran Jayasundera; Elliott H. Sohn; Thomas W. Gardner
Tags: diabetes mellitus, retinal diseases, diagnostic imaging, dorsal raphe nucleus
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 519-527. doi:https://doi.org/10.1167/iovs.17-21873
Outer Retinal Dysfunction in the Absence of Structural Abnormalities in Multiple Sclerosis Open Access
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James V. M. Hanson; Michael Hediger; Praveena Manogaran; Klara Landau; Niels Hagenbuch; Sven Schippling; Christina Gerth-Kahlert
Tags: electroretinography, eye, multiple sclerosis, pathophysiology, cohort studies
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 549-560. doi:https://doi.org/10.1167/iovs.17-22821
Lycium Barbarum Polysaccharides Protect Retina in rd1 Mice During Photoreceptor Degeneration Open Access
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Feng Liu; Jia Zhang; Zongqin Xiang; Di Xu; Kwok-Fai So; Noga Vardi; Ying Xu
Tags: mice, photoreceptors, polysaccharides, retina, tissue degeneration
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 597-611. doi:https://doi.org/10.1167/iovs.17-22881

Retinal Cell Biology

The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation Open Access
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Joanna A. Phipps; Kirstan A. Vessey; Alice Brandli; Nupur Nag; Mai X. Tran; Andrew I. Jobling; Erica L. Fletcher
Tags: angiotensin ii, microglia, signal transduction, retina, intravitreal injections
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 487-498. doi:https://doi.org/10.1167/iovs.17-22416
Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes Open Access
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Jinling Fu; Mikiko Nagashima; Chuanyu Guo; Pamela A. Raymond; Xiangyun Wei
Tags: animal model, photoreceptors, proteins, retinal cone, retinal degeneration
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 505-518. doi:https://doi.org/10.1167/iovs.17-22572

Visual Neuroscience

Optimal Audiovisual Integration in the Ventriloquism Effect But Pervasive Deficits in Unisensory Spatial Localization in Amblyopia Open Access
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Michael D. Richards; Herbert C. Goltz; Agnes M. F. Wong
Tags: amblyopia, precision
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 122-131. doi:https://doi.org/10.1167/iovs.17-22504
Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry Open Access
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David T. Stark; David M. G. Anderson; Jacky M. K. Kwong; Nathan Heath Patterson; Kevin L. Schey; Richard M. Caprioli; Joseph Caprioli
Tags: diagnostic imaging, lipids, mass spectrometry, optic nerve regeneration, wounds and injuries
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 212-222. doi:https://doi.org/10.1167/iovs.17-22509
Melanopsin System Dysfunction in Smith-Magenis Syndrome Patients Open Access
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Mirella Telles Salgueiro Barboni; Clarissa Bueno; Balázs Vince Nagy; Patrícia Lobo Maia; Kallene Summer Moreira Vidal; Rosana Cardoso Alves; Russel J. Reiter; Fernanda Gaspar do Amaral; José Cipolla-Neto; Dora Fix Ventura
Tags: melanopsin, pathophysiology, smith-magenis syndrome
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 362-369. doi:https://doi.org/10.1167/iovs.17-22612
Microfluidics-Based Subretinal Chemical Neuromodulation of Photoreceptor Degenerated Retinas Open Access
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Corey M. Rountree; John B. Troy; Laxman Saggere
Tags: glutamate, glutamates, photoreceptors, retina, percutaneous neuromodulation therapy
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 418-430. doi:https://doi.org/10.1167/iovs.17-23142
Dopamine Deficiency Mediates Early Rod-Driven Inner Retinal Dysfunction in Diabetic Mice Open Access
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Moon K. Kim; Moe H. Aung; Lukas Mees; Darin E. Olson; Nikita Pozdeyev; P. Michael Iuvone; Peter M. Thule; Machelle T. Pardue
Tags: diabetes mellitus, dopamine, mice, pathophysiology, rod photoreceptors
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 572-581. doi:https://doi.org/10.1167/iovs.17-22692

Visual Psychophysics and Physiological Optics

Balanced Eyes See Stereopsis More Quickly, but Not More Finely Open Access
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Haoran Wu; Hua Bi; Xuhong Zhang; Zheyi Chen; Weizhong Lan; Xiaoning Li; Bin Zhang; Zhikuan Yang
Tags: depth perception, eye, ocular dominance
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 499-504. doi:https://doi.org/10.1167/iovs.17-22849

Review

Pharmacology of Corticosteroids for Diabetic Macular Edema Open Access
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Scott M. Whitcup; John A. Cidlowski; Karl G. Csaky; Jayakrishna Ambati
Tags: adrenal corticosteroids, glucocorticoids, mineralocorticoids, diabetic macular edema
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 1-12. doi:https://doi.org/10.1167/iovs.17-22259

Letters to the Editor

Increased mtDNA Copy Number Does Not Protect Against LHON Open Access
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Josef Finsterer; Sinda Zarrouk-Mahjoub
Tags: dna, mitochondrial, optic atrophy, hereditary, leber
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 330. doi:https://doi.org/10.1167/iovs.17-22640
Author Response: Increased mtDNA Copy Number Protects Against LHON Open Access
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Angelica Bianco; Luigi L. Palese; Silvana Guerriero; Vittoria Petruzzella
Tags: dna, mitochondrial, optic atrophy, hereditary, leber
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 331. doi:https://doi.org/10.1167/iovs.17-22822
Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than the Haplotype or Heteroplasmy Rate Open Access
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Josef Finsterer; Sinda Zarrouk-Mahjoub
Tags: haplotypes, heteroplasmy, mutation, optic atrophy, hereditary, leber, penetrance, genetic
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 381. doi:https://doi.org/10.1167/iovs.17-22983
Author Response: Penetrance of the LHON Mutation m.11778G>A May Depend on Factors Other Than Haplotype or Heteroplasmy Rate Open Access
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Nahid Akhtar Khan; Periyasamy Govindaraj; Nagasamy Soumittra; Sonika Sharma; Sundaramoorthy Srilekha; Selvakumar Ambika; Ayyasamy Vanniarajan; Angamuthu Kanikannan Meena; Megha S. Uppin; Challa Sundaram; Parayil Sankaran Bindu; Narayanappa Gayathri; Arun B. Taly; Kumarasamy Thangaraj
Tags: haplotypes, heteroplasmy, mutation, optic atrophy, hereditary, leber, penetrance, genetic
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 382. doi:https://doi.org/10.1167/iovs.17-23468
A Proposed Concentration-Controlled New Protocol for Optimal Corneal Crosslinking Efficacy in the Anterior Stroma Open Access
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Jui-teng Lin
Tags: corneal collagen cross-linking, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science January 2018, Vol.59, 431-432. doi:https://doi.org/10.1167/iovs.17-23414

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science January 2018, Vol.59, 144. doi:https://doi.org/10.1167/iovs.15-17241a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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