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Anatomy and Pathology/Oncology

Leucine-Rich α-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma Open Access
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Radgonde Amer; Liran Tiosano; Jacob Pe'er
Tags: glycoproteins, leucine, retinoblastoma, vascular endothelial growth factor a, neoplasms
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 685-692. doi:https://doi.org/10.1167/iovs.17-22785
A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis Open Access
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Dianlei Guo; Zhaohui Yuan; Jiali Ru; Xinyu Gu; Wang Zhang; Fuxiang Mao; Hong Ouyang; Kaili Wu; Yizhi Liu; Chunqiao Liu
Tags: eyelid, pentachlorophenol, phencyclidine, pneumonia, pneumocystis carinii, primary care physicians
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 952-966. doi:https://doi.org/10.1167/iovs.17-22947
HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status Open Access
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Jinfeng Cao; Niels J. Brouwer; Ekaterina S. Jordanova; Marina Marinkovic; Sjoerd G. van Duinen; Nadine E. de Waard; Bruce R. Ksander; Arend Mulder; Frans H. J. Claas; Mirjam H. M. Heemskerk; Martine J. Jager
Tags: human leukocyte antigens, programmed cell death 1 ligand 1, malignant melanoma of conjunctiva, human leukocyte antigen class i, cell lines
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1005-1015. doi:https://doi.org/10.1167/iovs.17-23209

Biochemistry and Molecular Biology

A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines Open Access
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Stéphanie Leruez; Thomas Bresson; Juan M. Chao de la Barca; Alexandre Marill; Grégoire de Saint Martin; Adrien Buisset; Jeanne Muller; Lydie Tessier; Cédric Gadras; Christophe Verny; Patrizia Amati-Bonneau; Guy Lenaers; Philippe Gohier; Dominique Bonneau; Gilles Simard; Dan Milea; Vincent Procaccio; Pascal Reynier
Tags: amino acids, exfoliation syndrome, metabolomics, plasma, polyamines
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1025-1032. doi:https://doi.org/10.1167/iovs.17-23055
Type VII Collagen in the Human Accommodation System: Expression in Ciliary Body, Zonules, and Lens Capsule Open Access
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Bart Wullink; Hendri H. Pas; Roelofje J. Van der Worp; Martin Schol; Sarah F. Janssen; Roel Kuijer; Leonoor I. Los
Tags: antibodies, ciliary body, collagen type vii, lens capsule, crystalline, visual accommodation
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1075-1083. doi:https://doi.org/10.1167/iovs.17-23425

Clinical and Epidemiologic Research

Clinical Age-Specific Seasonal Conjunctivitis Patterns and Their Online Detection in Twitter, Blog, Forum, and Comment Social Media Posts Open Access
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Michael S. Deiner; Stephen D. McLeod; James Chodosh; Catherine E. Oldenburg; Cherie A. Fathy; Thomas M. Lietman; Travis C. Porco
Tags: conjunctivitis, allergic conjunctivitis, electronic medical records
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 910-920. doi:https://doi.org/10.1167/iovs.17-22818
Use of the Posterior/Anterior Corneal Curvature Radii Ratio to Improve the Accuracy of Intraocular Lens Power Calculation: Eom's Adjustment Method Open Access
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Mingue Kim; Youngsub Eom; Hwa Lee; Young-Woo Suh; Jong Suk Song; Hyo Myung Kim
Tags: cornea, intraocular lens implant device
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1016-1024. doi:https://doi.org/10.1167/iovs.17-22405

Cornea

Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty Open Access
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Hiroyuki Yazu; Takefumi Yamaguchi; Naohiko Aketa; Kazunari Higa; Terumasa Suzuki; Yukari Yagi-Yaguchi; Yoshiyuki Satake; Takayuki Abe; Kazuo Tsubota; Jun Shimazaki
Tags: cytokine, descemet stripping endothelial keratoplasty, endothelial cells, keratoplasty, preoperative care
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 612-620. doi:https://doi.org/10.1167/iovs.17-23049
Effect of UVA/Riboflavin Collagen Crosslinking on Biomechanics of Artificially Swollen Corneas Open Access
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Hamed Hatami-Marbini; Sandeep M. Jayaram
Tags: biomechanics, cornea, corneal collagen cross-linking, riboflavin, ultraviolet a radiation
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 764-770. doi:https://doi.org/10.1167/iovs.17-22814
Association Between Ocular Surface Temperature and Tear Film Stability in Soft Contact Lens Wearers Open Access
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Takashi Itokawa; Yukinobu Okajima; Takashi Suzuki; Koji Kakisu; Hiroko Iwashita; Yoshitaka Murakami; Yuichi Hori
Tags: body temperature, capillary leak syndrome, contact lenses, hydrophilic, tear film finding, temperature
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 771-775. doi:https://doi.org/10.1167/iovs.17-23173
Administration of Nitric Oxide Through a Novel Copper-Chitosan Delivery System in Human Corneal and Limbal Epithelial Cell Injury Open Access
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Vasiliki Tellios; Hong Liu; Nikoleta Tellios; Xiangji Li; Cindy M. L. Hutnik
Tags: chitosan, copper, cornea, epithelial cells, nitric oxide
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 967-977. doi:https://doi.org/10.1167/iovs.17-23044
Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo Open Access
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Suneel Gupta; Michael K. Fink; Arkasubhra Ghosh; Ratnakar Tripathi; Prashant R. Sinha; Ajay Sharma; Nathan P. Hesemann; Shyam S. Chaurasia; Elizabeth A. Giuliano; Rajiv R. Mohan
Tags: apoptosis, cornea, corneal opacity, fibrosis, gene therapy
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1045-1057. doi:https://doi.org/10.1167/iovs.17-23308
An Investigation of the Effects of Riboflavin Concentration on the Efficacy of Corneal Cross-Linking Using an Enzymatic Resistance Model in Porcine Corneas Open Access
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Naomi A. L. O'Brart; David P. S. O'Brart; Nada H. Aldahlawi; Sally Hayes; Keith M. Meek
Tags: body weight, cornea, corneal collagen cross-linking, mass or substance concentration per volume, riboflavin
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1058-1065. doi:https://doi.org/10.1167/iovs.17-22994

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Eye Movement Control in the Argus II Retinal-Prosthesis Enables Reduced Head Movement and Better Localization Precision Open Access
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Avi Caspi; Arup Roy; Varalakshmi Wuyyuru; Paul E. Rosendall; Jason W. Harper; Kapil D. Katyal; Michael P. Barry; Gislin Dagnelie; Robert J. Greenberg
Tags: eye, eye movement, head movements, precision, visual prosthesis
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 792-802. doi:https://doi.org/10.1167/iovs.17-22377
Retinothalamic White Matter Abnormalities in Amblyopia Open Access
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Brian Allen; Melanie A. Schmitt; Burton J. Kushner; Bas Rokers
Tags: amblyopia, optic nerve, white matter, leukoencephalopathies
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 921-929. doi:https://doi.org/10.1167/iovs.17-22930
Optical Properties Influence Visual Cortical Functional Resolution After Cataract Surgery and Both Dissociate From Subjectively Perceived Quality of Vision Open Access
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Ângela Sofia Cardoso Miranda; Andreia de Faria Martins Rosa; Miguel José Patrício Dias; Ben M. Harvey; Maria Fátima Loureiro da Silva; Miguel de Sá e Sousa Castelo-Branco; Joaquim Carlos Neto Murta
Tags: cataract surgery, optics, perception, prolactin-releasing hormone, vision
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 986-994. doi:https://doi.org/10.1167/iovs.17-22321
Rapid Objective Assessment of Contrast Sensitivity and Visual Acuity With Sweep Visual Evoked Potentials and an Extended Electrode Array Open Access
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Coralie Hemptinne; Joan Liu-Shuang; Demet Yuksel; Bruno Rossion
Tags: contrast sensitivity, electroencephalography, evoked potentials, visual, visual acuity, spatial frequency
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1144-1157. doi:https://doi.org/10.1167/iovs.17-23248

Genetics

Stargardt Phenotype Associated With Two ELOVL4 Promoter Variants and ELOVL4 Downregulation: New Possible Perspective to Etiopathogenesis? Open Access
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Luigi Donato; Concetta Scimone; Carmela Rinaldi; Pasquale Aragona; Silvana Briuglia; Angela D'Ascola; Rosalia D'Angelo; Antonina Sidoti
Tags: down-regulation, luciferases, phenotype, polyunsaturated fatty acids, genes
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 843-857. doi:https://doi.org/10.1167/iovs.17-22962
The Genetics of Usher Syndrome in the Israeli and Palestinian Populations Open Access
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Ayat Khalaileh; Alaa Abu-Diab; Tamar Ben-Yosef; Annick Raas-Rothschild; Israela Lerer; Yahya Alswaiti; Itay Chowers; Eyal Banin; Dror Sharon; Samer Khateb
Tags: genetics, mutation, usher syndrome, family
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1095-1104. doi:https://doi.org/10.1167/iovs.17-22817
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease Open Access
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Yingying Yue; Jun Zhang; Lu Yang; Shengyun Liu; Jian Qi; Qingfeng Cao; Chunjiang Zhou; Yao Wang; Aize Kijlstra; Peizeng Yang; Shengping Hou
Tags: ankylosing spondylitis, behcet syndrome, genotype, il12b gene, polymorphism
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1158-1166. doi:https://doi.org/10.1167/iovs.17-23247

Glaucoma

Deep Defects Seen on Visual Fields Spatially Correspond Well to Loss of Retinal Nerve Fiber Layer Seen on Circumpapillary OCT Scans Open Access
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Maria A. Mavrommatis; Zhichao Wu; Saskia I. Naegele; Jason Nunez; Carlos Gustavo De Moraes; Robert Ritch; Donald C. Hood
Tags: eye, visual fields, fovea centralis
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 621-628. doi:https://doi.org/10.1167/iovs.17-23097
Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets Open Access
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Jessica N. Cooke Bailey; Puya Gharahkhani; Jae H. Kang; Mariusz Butkiewicz; David A. Sullivan; Robert N. Weinreb; Hugues Aschard; R. Rand Allingham; Allison Ashley-Koch; Richard K. Lee; Sayoko E. Moroi; Murray H. Brilliant; Gadi Wollstein; Joel S. Schuman; John H. Fingert; Donald L. Budenz; Tony Realini; Terry Gaasterland; William K. Scott; Kuldev Singh; Arthur J. Sit; Robert P. Igo, Jr; Yeunjoo E. Song; Lisa Hark; Robert Ritch; Douglas J. Rhee; Douglas Vollrath; Donald J. Zack; Felipe Medeiros; Thasarat S. Vajaranant; Daniel I. Chasman; William G. Christen; Margaret A. Pericak-Vance; Yutao Liu; Peter Kraft; Julia E. Richards; Bernard A. Rosner; Michael A. Hauser; Jamie E. Craig; Kathryn P. Burdon; Alex W. Hewitt; David A. Mackey; Jonathan L. Haines; Stuart MacGregor; Janey L. Wiggs; Louis R. Pasquale; for the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
Tags: genes, glaucoma, metabolism, open-angle glaucoma, testosterone
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 629-636. doi:https://doi.org/10.1167/iovs.17-22708
Autotaxin–Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes Open Access
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Megumi Honjo; Nozomi Igarashi; Makoto Kurano; Yutaka Yatomi; Koji Igarashi; Kuniyuki Kano; Junken Aoki; Robert N. Weinreb; Makoto Aihara
Tags: glaucoma, hypertension, intraocular pressure, regulation
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 693-701. doi:https://doi.org/10.1167/iovs.17-23218
Mesenchymal Stem Cell–Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma Open Access
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Ben Mead; Juan Amaral; Stanislav Tomarev
Tags: extracellular vesicles, glaucoma, lasers, light coagulation, mesenchymal stem cells
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 702-714. doi:https://doi.org/10.1167/iovs.17-22855
A Naturally Fluorescent Mgp Transgenic Mouse for Angiogenesis and Glaucoma Longitudinal Studies Open Access
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Priyadarsini Asokan; Rajendra N. Mitra; Ramesh Periasamy; Zongchao Han; Teresa Borrás
Tags: glaucoma, mice, angiogenesis, mice, transgenic, eye
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 746-756. doi:https://doi.org/10.1167/iovs.17-22992
Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells Open Access
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Baiyun Liu; Jason I. Kilpatrick; Bartlomiej Lukasz; Suzanne P. Jarvis; Fiona McDonnell; Deborah M. Wallace; Abbot F. Clark; Colm J. O'Brien
Tags: actins, cribriform plate, cues, glaucoma, phenotype
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 803-814. doi:https://doi.org/10.1167/iovs.17-22400
Activation of the NFAT–Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma Open Access
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Mustapha Irnaten; Alexander Zhdanov; Deirdre Brennan; Thomas Crotty; Abbot Clark; Dmitri Papkovsky; Colm O'Brien
Tags: glaucoma, hydrogen peroxide, cyclosporine, signal pathway, signal transduction pathways
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 831-842. doi:https://doi.org/10.1167/iovs.17-22531
Sampling the Visual Field Based on Individual Retinal Nerve Fiber Layer Thickness Profile Open Access
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Shonraj Ballae Ganeshrao; Andrew Turpin; Allison M. McKendrick
Tags: retinal nerve fiber layer, sampling method, visual fields
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1066-1074. doi:https://doi.org/10.1167/iovs.17-21979

Immunology and Microbiology

A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis Open Access
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Fleurieke H. Verhagen; Cornelis P. J. Bekker; Marzia Rossato; Sanne Hiddingh; Lieuwe de Vries; Abhinandan Devaprasad; Aridaman Pandit; Jeannette Ossewaarde-van Norel; Ninette ten Dam; Maartje C. A. Moret-Pot; Saskia M. Imhof; Joke H. de Boer; Timothy R. D. J. Radstake; Jonas J. W. Kuiper
Tags: micrornas, uveitis, leukocytes
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 878-888. doi:https://doi.org/10.1167/iovs.17-23643

Lens

Three-Dimensional Cataract Crystalline Lens Imaging With Swept-Source Optical Coherence Tomography Open Access
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Alberto de Castro; Antonio Benito; Silvestre Manzanera; Juan Mompeán; Belén Cañizares; David Martínez; Jose María Marín; Ireneusz Grulkowski; Pablo Artal
Tags: cataract, diagnostic imaging, lens, crystalline, optical coherence tomography, cataract surgery
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 897-903. doi:https://doi.org/10.1167/iovs.17-23596

Low Vision

Beneficial Effects of Spatial Remapping for Reading With Simulated Central Field Loss Open Access
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Anshul Gupta; Juraj Mesik; Stephen A. Engel; Rebecca Smith; Mark Schatza; Aurélie Calabrèse; Frederik J. van Kuijk; Arthur G. Erdman; Gordon E. Legge
Tags: reading (activity), scotoma, reading speed
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1105-1112. doi:https://doi.org/10.1167/iovs.16-21404

Multidisciplinary Ophthalmic Imaging

Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study Open Access
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Edouard Augstburger; Pierre Zéboulon; Chafik Keilani; Christophe Baudouin; Antoine Labbé
Tags: angiogram, blood capillaries, microvascular network, nonarteritic anterior ischemic optic neuropathy, optical coherence tomography
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 870-877. doi:https://doi.org/10.1167/iovs.17-22996
Light-Dependent OCT Structure Changes in Photoreceptor Degenerative rd 10 Mouse Retina Open Access
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Yichao Li; Yikui Zhang; Sonia Chen; Gregory Vernon; Wai T. Wong; Haohua Qian
Tags: mice, photoreceptors, retina, dark adaptation, eye
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1084-1094. doi:https://doi.org/10.1167/iovs.17-23011
Corneal Nerve Fractal Dimension: A Novel Corneal Nerve Metric for the Diagnosis of Diabetic Sensorimotor Polyneuropathy Open Access
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Xin Chen; Jim Graham; Ioannis N. Petropoulos; Georgios Ponirakis; Omar Asghar; Uazman Alam; Andrew Marshall; Maryam Ferdousi; Shazli Azmi; Nathan Efron; Rayaz A. Malik
Tags: cornea, diabetes mellitus, fractals, neurons, polyneuropathy, sensory-motor
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1113-1118. doi:https://doi.org/10.1167/iovs.17-23342

Physiology and Pharmacology

A Biodegradable, Sustained-Released, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model Open Access
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Yu-Chi Liu; Xu Wen Ng; Ericia Pei Wen Teo; Heng-Pei Ang; Nyein Chan Lwin; Nicole Shu Wen Chan; Subbu S. Venkatraman; Tina T. Wong; Jodhbir S. Mehta
Tags: allergic conjunctivitis, drug delivery systems, mice, tacrolimus, drug release
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 675-684. doi:https://doi.org/10.1167/iovs.17-23066
Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models Open Access
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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
Tags: animal model, complement activation, complement factor d, complement system proteins, eye
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 940-951. doi:https://doi.org/10.1167/iovs.17-22605
Intravitreal Stanniocalcin-1 Enhances New Blood Vessel Growth in a Rat Model of Laser-Induced Choroidal Neovascularization Open Access
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Min Zhao; Wankun Xie; Shu-Huai Tsai; Travis W. Hein; Brent A. Rocke; Lih Kuo; Robert H. Rosa, Jr
Tags: choroidal neovascularization, lasers
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1125-1133. doi:https://doi.org/10.1167/iovs.17-23083

Retina

Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes Open Access
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Nobuhiro Nagai; Shinji Yamada; Junichi Kawasaki; Eri Koyanagi; Saaya Saijo; Hirokazu Kaji; Matsuhiko Nishizawa; Toru Nakazawa; Toshiaki Abe
Tags: cercopithecidae, electroretinography, eye, implantation procedure, safety
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 644-652. doi:https://doi.org/10.1167/iovs.17-22429
Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy Open Access
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Jeanette Eresch; Martin Stumpf; Alexander Koch; Rajkumar Vutukuri; Nerea Ferreirós; Yannick Schreiber; Katrin Schröder; Kavi Devraj; Rüdiger Popp; Andrea Huwiler; Lars-Olof Hattenbach; Josef Pfeilschifter; Waltraud Pfeilschifter
Tags: mice, neovascularization, pathologic, oxygen, phosphotransferases, retinal diseases
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 653-661. doi:https://doi.org/10.1167/iovs.17-22544
Association Between Soluble CD14 in the Aqueous Humor and Hyperreflective Foci on Optical Coherence Tomography in Patients With Diabetic Macular Edema Open Access
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Hyungwoo Lee; Hyoik Jang; Youn A Choi; Hyung Chan Kim; Hyewon Chung
Tags: aqueous humor, cd14 antigen, diabetic macular edema, edema, heart failure
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 715-721. doi:https://doi.org/10.1167/iovs.17-23042
A Novel Choroidal Endothelial Cell Line Has a Decreased Affinity for the Age-Related Macular Degeneration–Associated Complement Factor H Variant 402H Open Access
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Markus A. Loeven; Jasper J. van Gemst; Carolien M. S. Schophuizen; Viranga Tilakaratna; Lambert P. van den Heuvel; Anthony J. Day; B. Jeroen Klevering; Johan van der Vlag
Tags: age-related macular degeneration, complement factor h, endothelial cells, endothelium, affinity
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 722-730. doi:https://doi.org/10.1167/iovs.IOVS-17-22893
Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors Open Access
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Tian Wu; Li Zhang; Yu Tong; Yi Qu; Bin Xia; Dezhi Mu
Tags: china, chinese (other dialects), chinese people, incidence, infant
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 757-763. doi:https://doi.org/10.1167/iovs.17-23158
Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy Open Access
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Devy Deliyanti; Saeed F. Alrashdi; Sih Min Tan; Colin Meyer; Keith W. Ward; Judy B. de Haan; Jennifer L. Wilkinson-Berka
Tags: antioxidants, attenuation, diabetes mellitus, diabetic retinopathy, retina
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 815-825. doi:https://doi.org/10.1167/iovs.17-22920
Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa Open Access
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Yasuhiro Ikeda; Koji M. Nishiguchi; Fuyuki Miya; Nobuhiro Shimozawa; Jun Funatsu; Shunji Nakatake; Kohta Fujiwara; Takashi Tachibana; Yusuke Murakami; Toshio Hisatomi; Shigeo Yoshida; Yasuhiro Yasutomi; Tatsuhiko Tsunoda; Toru Nakazawa; Tatsuro Ishibashi; Koh-Hei Sonoda
Tags: cercopithecidae, family, macaca fascicularis, retinitis pigmentosa, eye
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 826-830. doi:https://doi.org/10.1167/iovs.17-22958
EVEREST Report 5: Clinical Outcomes and Treatment Response of Polypoidal Choroidal Vasculopathy Subtypes in a Multicenter, Randomized Controlled Trial Open Access
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Colin S. Tan; Louis W. Lim; Wei Kiong Ngo; Tock Han Lim; for the EVEREST Study Group
Tags: polyps, randomized controlled trial, treatment outcome, vascular diseases, diagnostic imaging
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 889-896. doi:https://doi.org/10.1167/iovs.17-22683
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome Open Access
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Douglas A. Jabs; Mark L. Van Natta; Jeong Won Pak; Ronald P. Danis; Peter W. Hunt
Tags: acquired immunodeficiency syndrome, age-related macular degeneration, retinal vascular caliber, retinal vasculature
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 904-908. doi:https://doi.org/10.1167/iovs.17-23334
Enhanced Expression of NLRP3 Inflammasome-Related Inflammation in Diabetic Retinopathy Open Access
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Hui Chen; Xiongze Zhang; Nanying Liao; Lan Mi; Yuting Peng; Bing Liu; Shaochong Zhang; Feng Wen
Tags: diabetic retinopathy, inflammation, interleukin-18, vitreous body
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 978-985. doi:https://doi.org/10.1167/iovs.17-22816
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis Open Access
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Yuriko Minegishi; Naoki Nakaya; Stanislav I. Tomarev
Tags: cell cycle, cell death, eye, genes, homozygote
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 995-1004. doi:https://doi.org/10.1167/iovs.17-22919
Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration Open Access
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Jingtai Cao; Thomas C. MacPherson; Bibiana V. Iglesias; Yang Liu; Natasha Tirko; George D. Yancopoulos; Stanley J. Wiegand; Carmelo Romano
Tags: aflibercept, eye, injections, oryctolagus cuniculus, retinal neovascularization
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1033-1044. doi:https://doi.org/10.1167/iovs.17-22897
Changes in Choroidal Thickness After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor in Pachychoroid Neovasculopathy Open Access
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Noel Padrón-Pérez; Luis Arias; Marcos Rubio; Daniel Lorenzo; Pere García-Bru; Jaume Català-Mora; José M. Caminal
Tags: anti-vascular endothelial growth factor therapy, endothelial growth factors, eye, intravitreal injections, follow-up
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1119-1124. doi:https://doi.org/10.1167/iovs.17-22144
Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa Open Access
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Yusuke Murakami; Jun Funatsu; Shunji Nakatake; Kohta Fujiwara; Takashi Tachibana; Yoshito Koyanagi; Toshio Hisatomi; Shigeo Yoshida; Shozo Sonoda; Taiji Sakamoto; Koh-Hei Sonoda; Yasuhiro Ikeda
Tags: retinitis pigmentosa, vascular flow, vision, choroid
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 1134-1143. doi:https://doi.org/10.1167/iovs.17-23050

Retinal Cell Biology

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration Open Access
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Christopher B. Toomey; Michael Landowski; Mikael Klingeborn; Una Kelly; John Deans; Holly Dong; Ons Harrabi; Thomas Van Blarcom; Yik Andy Yeung; Ruslan Grishanin; John C. Lin; Daniel R. Saban; Catherine Bowes Rickman
Tags: mice, antibodies, choroidal neovascularization, age-related macular degeneration, choroid
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 662-673. doi:https://doi.org/10.1167/iovs.17-23134
Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina Open Access
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Kirstan A. Vessey; Tracy Ho; Andrew I. Jobling; Samuel A. Mills; Mai X. Tran; Alice Brandli; Jackson Lam; Robyn H. Guymer; Erica L. Fletcher
Tags: laser therapy, lasers, retina, mice, age-related macular degeneration
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 731-745. doi:https://doi.org/10.1167/iovs.17-23098
Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning Open Access
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Wataru Kobayashi; Akishi Onishi; Hung-Ya Tu; Yuji Takihara; Michiru Matsumura; Kazuko Tsujimoto; Masaru Inatani; Toru Nakazawa; Masayo Takahashi
Tags: mice, organoids, pluripotent stem cells, retinal ganglion cells, immunohistochemistry
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 776-787. doi:https://doi.org/10.1167/iovs.17-22406
Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity Open Access
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Lynn Calvin Shaw; Sergio Li Calzi; Nan Li; Leni Moldovan; Nilanjana Sengupta-Caballero; Judith Lindsey Quigley; Mircea Ivan; Bokkyoo Jun; Nicolas G. Bazan; Michael Edwin Boulton; Julia Busik; Josef Neu; Maria B. Grant
Tags: dipeptides, mice, neovascularization, pathologic, retinopathy of prematurity, docosahexaenoic acids
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 858-869. doi:https://doi.org/10.1167/iovs.17-23034
Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice Open Access
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Ting Su; Yisheng Zhong; Anna M. Demetriades; Jikui Shen; Ailing Sui; Yiyun Yao; Yushuo Gao; Yanji Zhu; Xi Shen; Bing Xie
Tags: angiogenesis, mice, neovascularization, pathologic, vascular endothelial growth factor a, choroidal neovascularization
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 930-939. doi:https://doi.org/10.1167/iovs.17-22945

Visual Neuroscience

Temporal Ventriloquism Reveals Intact Audiovisual Temporal Integration in Amblyopia Open Access
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Michael D. Richards; Herbert C. Goltz; Agnes M. F. Wong
Tags: amblyopia
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 637-643. doi:https://doi.org/10.1167/iovs.17-22613

Perspective

Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields Open Access
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Donald C. Hood; Carlos Gustavo De Moraes
Tags: glaucoma, visual fields
Investigative Ophthalmology & Visual Science February 2018, Vol.59, 788-791. doi:https://doi.org/10.1167/iovs.17-23713

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science February 2018, Vol.59, 674. doi:https://doi.org/10.1167/iovs.17-21764a
Erratum Open Access
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Investigative Ophthalmology & Visual Science February 2018, Vol.59, 909. doi:https://doi.org/10.1167/iovs.16-21377a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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