Volume 59 Issue 3 | IOVS

Thank You to Our Reviewers Open Access

Thomas Yorio

Tags: community, ophthalmology, peer review, vision, vision research

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1538. doi:https://doi.org/https://doi.org/10.1167/iovs.18-23983

Reviewers Open Access

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Tags: acetylcholine, achondroplasia, arthritis, juvenile rheumatoid, atrial myxoma with lentigines, barrett's esophagus

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1539-1546. doi:https://doi.org/10.1167/iovs.18-24048

Anatomy and Pathology/Oncology

Quantitative Evaluation of Vascular Microcirculation Using Contrast-Enhanced Ultrasound Imaging In Rabbit Models of Choroidal Melanoma Open Access

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Min Gao; Jinhua Tang; Kun Liu; Ming Yang; Haiyun Liu

Tags: diagnostic imaging, malignant melanoma of choroid, melanoma, microcirculation, neoplasms

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1251-1262. doi:https://doi.org/10.1167/iovs.17-22197

Macrophage-Associated Gelatinase Degrades Basement Membrane at the Optic Fissure Margins During Normal Ocular Development in Mice Open Access

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Naho Tsuji; Tetsuro Matsuura; Isao Narama; Atsushi Yoshiki; Kiyokazu Ozaki

Tags: basement membrane, fissure, gelatinases, macrophages, matrix metalloproteinases

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1368-1373. doi:https://doi.org/10.1167/iovs.17-21841

Biochemistry and Molecular Biology

Gene Expression and Pathways Underlying Form Deprivation Myopia in the Guinea Pig Sclera Open Access

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Nethrajeith Srinivasalu; Sally A. McFadden; Callan Medcalf; Lena Fuchs; Jessica Chung; Gayle Philip; Andrea Richardson; Moeen Riaz; Paul N. Baird

Tags: eye, gene expression, guinea, myopia, sclera

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1425-1434. doi:https://doi.org/10.1167/iovs.16-21278

Bevacizumab Promotes T-Cell–Mediated Collagen Deposition in the Mouse Model of Conjunctival Scarring Open Access

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Li-Fong Seet; Li Zhen Toh; Stephanie Chu; Sharon N. Finger; Florent Ginhoux; Wanjin Hong; Tina T. Wong

Tags: bevacizumab, cicatrix, conjunctiva, mice, t-lymphocytes

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1682-1692. doi:https://doi.org/10.1167/iovs.17-22694

Clinical and Epidemiologic Research

Distribution Pattern of Choroidal Thickness at the Posterior Pole in Chinese Children With Myopia Open Access

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Junjie Deng; Xiaoli Li; Jiali Jin; Bo Zhang; Jianfeng Zhu; Haidong Zou; Xun Xu; Jingbo Xie; Ling Wang; Shaopin Zhu; Xiangui He

Tags: child, chinese (other dialects), chinese people, myopia, choroid

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1577-1586. doi:https://doi.org/10.1167/iovs.17-22748

Cornea

Mesenchymal Stromal Cells Inhibit Neutrophil Effector Functions in a Murine Model of Ocular Inflammation Open Access

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Sharad K. Mittal; Alireza Mashaghi; Afsaneh Amouzegar; Mingshun Li; William Foulsham; Srikant K. Sahu; Sunil K. Chauhan

Tags: mesenchymal stem cells, mice, neutrophils, stromal cells, cornea

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1191-1198. doi:https://doi.org/10.1167/iovs.17-23067

Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography Open Access

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Matthias Brunner; Vito Romano; Bernhard Steger; Riccardo Vinciguerra; Samuel Lawman; Bryan Williams; Nicholas Hicks; Gabriela Czanner; Yalin Zheng; Colin E. Willoughby; Stephen B. Kaye

Tags: angiogram, corneal neovascularization, diagnostic imaging, fluorescence, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1263-1269. doi:https://doi.org/10.1167/iovs.17-22035

Substance P Modulation of Human and Murine Corneal Neovascularization Open Access

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Marco Barbariga; Phillippe Fonteyne; Manoosh Ostadreza; Fabio Bignami; Paolo Rama; Giulio Ferrari

Tags: choroidal neovascularization, cornea, corneal neovascularization, mice, substance p

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1305-1312. doi:https://doi.org/10.1167/iovs.17-23198

Differentiation Patterns of Immortalized Human Meibomian Gland Epithelial Cells in Three-Dimensional Culture Open Access

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Nagayoshi Asano; Ulrike Hampel; Fabian Garreis; Antje Schröder; Martin Schicht; Christian M. Hammer; Friedrich Paulsen

Tags: cell culture techniques, cell lines, epithelial cells, lipids, meibomian gland

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1343-1353. doi:https://doi.org/10.1167/iovs.17-23266

Human Conjunctival Epithelial Sheets Grown on Poly(Lactic-Co-Glycolic) Acid Membranes and Cocultured With Human Tenon's Fibroblasts for Corneal Repair Open Access

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Soyoung Hong; Je Hwan Yun; Eun-Soon Kim; Ji Seon Kim; Hungwon Tchah; Changmo Hwang

Tags: conjunctiva, cornea, epithelium, fibroblasts, tissue membrane

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1475-1485. doi:https://doi.org/10.1167/iovs.17-22719

A Cell Culture Approach to Optimized Human Corneal Endothelial Cell Function Open Access

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Alena Bartakova; Olga Kuzmenko; Karen Alvarez-Delfin; Noelia J. Kunzevitzky; Jeffrey L. Goldberg

Tags: cd56 antigens, cell culture techniques, cornea, cyclic gmp, endothelial cells

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1617-1629. doi:https://doi.org/10.1167/iovs.17-23637

Visualizing the Fate of Transplanted K14-Confetti Corneal Epithelia in a Mouse Model of Limbal Stem Cell Deficiency Open Access

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Alexander Richardson; Mijeong Park; Stephanie L. Watson; Denis Wakefield; Nick Di Girolamo

Tags: donors, mice, transplantation, corneal epithelium, limbal stem cell deficiency

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1630-1640. doi:https://doi.org/10.1167/iovs.17-23557

Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7–Null Mouse Cornea Open Access

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Stacy L. Littlechild; Robert D. Young; Bruce Caterson; Hideyuki Yoshida; Maya Yamazaki; Kenji Sakimura; Andrew J. Quantock; Tomoya O. Akama

Tags: cornea, keratan sulfate, mice, knockout, phenotype, body tissue

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1641-1651. doi:https://doi.org/10.1167/iovs.17-22716

Wide Corneal Epithelial Mapping Using an Optical Coherence Tomography Open Access

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Nauman Hashmani; Sharif Hashmani; Choudhry M. Saad

Tags: cornea, epithelium, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1652-1658. doi:https://doi.org/10.1167/iovs.17-23717

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 (Sod1) Knockout Mice Open Access

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Takashi Kojima; Cem Simsek; Ayako Igarashi; Kazue Aoki; Kazunari Higa; Takahiko Shimizu; Murat Dogru; Kazuo Tsubota; Jun Shimazaki

Tags: conjunctiva, eyedrops, mice, rebamipide, sod1 gene

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1675-1681. doi:https://doi.org/10.1167/iovs.17-23213

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Changes in Myosin Heavy Chain Isoforms Along the Length of Orbital Fibers in Rabbit Extraocular Muscle Open Access

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Christine A. Lucas; Hannah S. M. Rhee; Joseph F. Y. Hoh

Tags: muscle of orbit, myosin heavy chains, myosins, oryctolagus cuniculus, protein isoforms

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1178-1190. doi:https://doi.org/10.1167/iovs.17-23102

SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis Open Access

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Devin S. McDougald; Kimberly E. Dine; Alexandra U. Zezulin; Jean Bennett; Kenneth S. Shindler

Tags: gene transfer techniques, genes, neuroprotection, neuroprotective effect, optic neuritis

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1212-1220. doi:https://doi.org/10.1167/iovs.17-22972

Improved Binocular Outcomes Following Binocular Treatment for Childhood Amblyopia Open Access

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Krista R. Kelly; Reed M. Jost; Yi-Zhong Wang; Lori Dao; Cynthia L. Beauchamp; Joel N. Leffler; Eileen E. Birch

Tags: amblyopia, amblyopia, pediatric, child, visual acuity, eye

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1221-1228. doi:https://doi.org/10.1167/iovs.17-23235

Detection of Amblyopia Using Sweep VEP Vernier and Grating Acuity Open Access

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Chuan Hou; William V. Good; Anthony M. Norcia

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1435-1442. doi:https://doi.org/10.1167/iovs.17-23021

An Anatomic Characterization of the Midbrain Near Response Neurons in the Macaque Monkey Open Access

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Paul J. May; Susan Warren; Paul D. R. Gamlin; Isabelle Billig

Tags: accommodative reflex, cercopithecidae, midbrain, neurons, rabies

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1486-1502. doi:https://doi.org/10.1167/iovs.17-23737

Genetics

Comprehensive Molecular Screening in Chinese Usher Syndrome Patients Open Access

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Tengyang Sun; Ke Xu; Yanfan Ren; Yue Xie; Xiaohui Zhang; Lu Tian; Yang Li

Tags: chinese (other dialects), chinese people, genes, mutation, screening

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1229-1237. doi:https://doi.org/10.1167/iovs.17-23312

Glaucoma

Anterior Choroidal Thickness Increased in Primary Open-Angle Glaucoma and Primary Angle-Closure Disease Eyes Evidenced by Ultrasound Biomicroscopy and SS-OCT Open Access

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Kai Gao; Fei Li; Yingqi Li; Xingyi Li; Wenbin Huang; Shida Chen; Yaoming Liu; Tin Aung; Xiulan Zhang

Tags: choroid, eye, glaucoma, open-angle glaucoma, phased thoracic-abdominal compression-decompression

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1270-1277. doi:https://doi.org/10.1167/iovs.17-23037

Asymmetric Patterns of Visual Field Defect in Primary Open-Angle and Primary Angle-Closure Glaucoma Open Access

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Siamak Yousefi; Hiroshi Sakai; Hiroshi Murata; Yuri Fujino; David Garway-Heath; Robert Weinreb; Ryo Asaoka

Tags: angle closure glaucoma, eye, open-angle glaucoma, scotoma, visual field defects

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1279-1287. doi:https://doi.org/10.1167/iovs.17-22980

White Matter Abnormalities and Correlation With Severity in Normal Tension Glaucoma: A Whole Brain Atlas-Based Diffusion Tensor Study Open Access

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Rong Wang; Zuohua Tang; Xinghuai Sun; Lingjie Wu; Jie Wang; Yufeng Zhong; Zebin Xiao

Tags: brain, diffusion, leukoencephalopathies, low tension glaucoma, white matter

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1313-1322. doi:https://doi.org/10.1167/iovs.17-23597

What Are the Characteristics of Primary Angle Closure With Longer Axial Length? Open Access

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Mengwei Li; Yuhong Chen; Zhenying Jiang; Xiaoxiao Chen; Junyi Chen; Xinghuai Sun

Tags: advanced life support, amyotrophic lateral sclerosis, antidepressive agents, tricyclic, antilymphocyte globulin, atypical

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1354-1359. doi:https://doi.org/10.1167/iovs.17-23711

The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure Open Access

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Hannah C. Webber; Jaclyn Y. Bermudez; J. Cameron Millar; Weiming Mao; Abbot F. Clark

Tags: cadherins, signal transduction, intraocular pressure

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1454-1466. doi:https://doi.org/10.1167/iovs.17-21964

Diagnostic Performance and Repeatability of a Novel Game-Based Visual Field Test for Children Open Access

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Tariq Mehmood Aslam; Zaria Christine Ali; Yanfang Wang; Cecilia Fenerty; Susmito Biswas; Emmanouil Tsamis; David Barry Henson

Tags: child, visual field testing

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1532-1537. doi:https://doi.org/10.1167/iovs.17-23546

Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography Open Access

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Sunee Chansangpetch; Anwell Nguyen; Marta Mora; Mai Badr; Mingguang He; Travis C. Porco; Shan C. Lin

Tags: nose, optical coherence tomography, software, anterior chamber of eye, eye

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1554-1561. doi:https://doi.org/10.1167/iovs.17-23574

Microvascular Density Is Associated With Retinal Ganglion Cell Axonal Volume in the Laminar Compartments of the Human Optic Nerve Head Open Access

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Min H. Kang; Mengchen Suo; Chandrakumar Balaratnasingam; Paula K. Yu; William H. Morgan; Dao-Yi Yu

Tags: cribriform plate, microvessels, optic disk, retinal ganglion cells, volume

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1562-1570. doi:https://doi.org/10.1167/iovs.17-23183

Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant Open Access

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Suqian Wu; Kun-Che Chang; Michael Nahmou; Jeffrey L. Goldberg

Tags: pluripotent stem cells, retinal ganglion cells, transplantation, coculture techniques, retina

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1571-1576. doi:https://doi.org/10.1167/iovs.17-23648

Immunology and Microbiology

Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity Open Access

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Juan Yun; Tong Xiao; Lei Zhou; Roger W. Beuerman; Juanjuan Li; Yuan Zhao; Amir Hadayer; Xiaomin Zhang; Deming Sun; Henry J. Kaplan; Hui Shao

Tags: autoimmunity, molecule, rats, recurrence, t-lymphocytes

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1332-1342. doi:https://doi.org/10.1167/iovs.17-23127

Retinal Pigment Epithelial Cells Control Early Mycobacterium tuberculosis Infection via Interferon Signaling Open Access

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Rina La Distia Nora; Kimberley V. Walburg; P. Martin van Hagen; Sigrid M. A. Swagemakers; Peter J. van der Spek; Edwin Quinten; Mirjam van Velthoven; Tom H. M. Ottenhoff; Willem A. Dik; Mariëlle C. Haks

Tags: infections, interferons, macrophages, retinal pigment cell, signal transduction

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1384-1395. doi:https://doi.org/10.1167/iovs.17-23246

Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II Open Access

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Derek J. Royer; Michael H. Elliott; Yun Z. Le; Daniel J. J. Carr

Tags: antigens, chronic exertional compartment syndrome, cornea, corneal epithelial cells, epithelial cell adhesion molecule

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1512-1522. doi:https://doi.org/10.1167/iovs.17-23279

Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis Open Access

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Xinyue Huang; Zi Ye; Qingfeng Cao; Guannan Su; Qingfeng Wang; Jing Deng; Chunjiang Zhou; Aize Kijlstra; Peizeng Yang

Tags: feces, metabolites, microbiome, phenotype, uveitis, anterior

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1523-1531. doi:https://doi.org/10.1167/iovs.17-22677

Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis Open Access

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Heather L. Clark; Martin S. Minns; Yan Sun; Tristan de Jesus; Mahmoud G. Ghannoum; Eric Pearlman

Tags: aspergillus, atovaquone, zinc, fusarium, mitochondria

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1589-1598. doi:https://doi.org/10.1167/iovs.17-22585

Multidisciplinary Ophthalmic Imaging

Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques Open Access

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Xin Wei; Shozo Sonoda; Chitaranjan Mishra; Neha Khandelwal; Ramasamy Kim; Taiji Sakamoto; Rupesh Agrawal

Tags: cortical blindness, optical coherence tomography, eye

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1206-1211. doi:https://doi.org/10.1167/iovs.17-22720

Physiology and Pharmacology

Changes in Blood Pressure and Urine Albumin-Creatinine Ratio in a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema Open Access

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Adam R. Glassman; Danni Liu; Lee M. Jampol; Jennifer K. Sun; for the Diabetic Retinopathy Clinical Research Network

Tags: albumins, bevacizumab, blood pressure, clinical trials, creatinine

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1199-1205. doi:https://doi.org/10.1167/iovs.17-22853

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders Open Access

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Suzanne Hagan; Matthew C. T. Fyfe; Boatemaa Ofori-Frimpong; Katherine Oliver; Martyn R. Foster; Sameer Sirohi; Yemisi Solanke; Michael Doughty; Adele Rowley; Mike Taylor; Steve Webber; Claire A. Walshe

Tags: dry eye syndromes, gene expression, hyperosmolality, hyperosmolar hyperglycemia, inflammatory disorders

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1443-1453. doi:https://doi.org/10.1167/iovs.17-23479

Retina

Predictive Mathematical Models for the Spread and Treatment of Hyperoxia-induced Photoreceptor Degeneration in Retinitis Pigmentosa Open Access

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Paul A. Roberts; Eamonn A. Gaffney; Jonathan P. Whiteley; Philip J. Luthert; Alexander J. E. Foss; Helen M. Byrne

Tags: hyperoxia, mutation, photoreceptors, tissue degeneration, retinitis pigmentosa

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1238-1249. doi:https://doi.org/10.1167/iovs.17-23177

Inner Retinal Microvasculature Damage Correlates With Outer Retinal Disruption During Remission in Behçet's Posterior Uveitis by Optical Coherence Tomography Angiography Open Access

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Dan Cheng; Meixiao Shen; Xiran Zhuang; Dan Lin; Mali Dai; Sisi Chen; Fan Lu; Yuqin Wang

Tags: angiogram, behcet syndrome, optical coherence tomography, uveitis, posterior, eye

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1295-1304. doi:https://doi.org/10.1167/iovs.17-23113

Beyond Hyperglycemia, Evidence for Retinal Neurodegeneration in Metabolic Syndrome Open Access

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Cagatay Karaca; Zuleyha Karaca

Tags: hyperglycemia, metabolic syndrome x, nerve degeneration

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1360-1367. doi:https://doi.org/10.1167/iovs.17-23376

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates Open Access

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Trevor J. McGill; Jonathan Stoddard; Lauren M. Renner; Ilhem Messaoudi; Kapil Bharti; Shoukhrat Mitalipov; Andreas Lauer; David J. Wilson; Martha Neuringer

Tags: primates, retinal pigment cell, tissue transplants, transplantation, idiopathic pneumonia syndrome

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1374-1383. doi:https://doi.org/10.1167/iovs.17-22467

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration Open Access

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Diego García-Ayuso; Johnny Di Pierdomenico; Wahiba Hadj-Said; Mélanie Marie; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Serge Picaud; María P. Villegas-Pérez

Tags: retinal degeneration, taurine, tissue degeneration, retinal cone, photoreceptors

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1396-1409. doi:https://doi.org/10.1167/iovs.17-23258

Safety Studies for a 44-Channel Suprachoroidal Retinal Prosthesis: A Chronic Passive Study Open Access

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Carla J. Abbott; David A. X. Nayagam; Chi D. Luu; Stephanie B. Epp; Richard A. Williams; Cesar M. Salinas-LaRosa; Joel Villalobos; Ceara McGowan; Mohit N. Shivdasani; Owen Burns; Jason Leavens; Jonathan Yeoh; Alice A. Brandli; Patrick C. Thien; Jenny Zhou; Helen Feng; Chris E. Williams; Robert K. Shepherd; Penelope J. Allen

Tags: eye, histopathology tests, implantation procedure, retina, safety

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1410-1424. doi:https://doi.org/10.1167/iovs.17-23086

Genetic Risk Factors for Radiation Vasculopathy Open Access

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Thanos D. Papakostas; Margaux A. Morrison; Anne Marie Lane; Caroline Awh; Margaret M. DeAngelis; Evangelos S. Gragoudas; Ivana K. Kim

Tags: genetic risk, radiation, single nucleotide polymorphism, vascular diseases, visual impairment

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1547-1553. doi:https://doi.org/10.1167/iovs.17-22791

Structure-Function Analysis in Patients With Intermediate Age-Related Macular Degeneration Open Access

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Marlene Saßmannshausen; Julia S. Steinberg; Rolf Fimmers; Maximilian Pfau; Sarah Thiele; Monika Fleckenstein; Frank G. Holz; Steffen Schmitz-Valckenberg

Tags: age-related macular degeneration, diagnostic imaging, drusen, eye, retina

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1599-1608. doi:https://doi.org/10.1167/iovs.17-22712

Parapapillary Gamma Zone and Progression of Myopia in School Children: The Beijing Children Eye Study Open Access

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Yin Guo; Li Juan Liu; Ping Tang; Yi Feng; Yan Yun Lv; Min Wu; Liang Xu; Jost B. Jonas

Tags: beijing, child, eye, myopia, school-age child

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1609-1616. doi:https://doi.org/10.1167/iovs.17-21665

Retinal Cell Biology

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure Open Access

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Mingzhe Cao; Jiamin Ouyang; Jingyi Guo; Siyuan Lin; Shuyi Chen

Tags: coloboma, embryo, eye, fissure, metalloproteases

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1167-1177. doi:https://doi.org/10.1167/iovs.17-22827

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy Open Access

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Elisabeth Richert; Stefan Koinzer; Jan Tode; Kerstin Schlott; Ralf Brinkmann; Jost Hillenkamp; Alexa Klettner; Johann Roider

Tags: biological response modifiers, bodily secretions, choroid, did not receive therapy or drug, fluorescent antibody technique

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1323-1331. doi:https://doi.org/10.1167/iovs.17-23163

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b^rd10 Mice Open Access

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Bruce A. Berkowitz; Robert H. Podolsky; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Robin Roberts

Tags: magnetic resonance imaging, mice, oxidative stress, rod photoreceptors, superoxides

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1659-1665. doi:https://doi.org/10.1167/iovs.17-22734

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1 Open Access

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Josy Augustine; Sofia Pavlou; Michael O'Hare; Kevin Harkin; Alan Stitt; Tim Curtis; Heping Xu; Mei Chen

Tags: mice, neuroglia, glutamate, cytokine, glial fibrillary acidic protein

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1666-1674. doi:https://doi.org/10.1167/iovs.17-23293

Visual Neuroscience

A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration Open Access

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Qi Lu; Tushar H. Ganjawala; Samer Hattar; Gary W. Abrams; Zhuo-Hua Pan

Tags: mice, miosis disorder, optogenetics, pupil constriction, vision

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1288-1294. doi:https://doi.org/10.1167/iovs.17-23278

A Novel Visual Psychometric Test for Light-Induced Discomfort Using Red and Blue Light Stimuli Under Binocular and Monocular Viewing Conditions Open Access

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Marija Zivcevska; Shaobo Lei; Alan Blakeman; Herbert C. Goltz; Agnes M. F. Wong

Tags: blue light, photophobia, psychometrics, psychophysics, melanopsin

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1467-1474. doi:https://doi.org/10.1167/iovs.17-23526

Visual Cortex Activation in Patients With Stargardt Disease Open Access

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Paolo Melillo; Anna Prinster; Valentina Di Iorio; Gaia Olivo; Francesco Maria D'Alterio; Sirio Cocozza; Ada Orrico; Mario Quarantelli; Francesco Testa; Arturo Brunetti; Francesca Simonelli

Tags: electroretinography, functional magnetic resonance imaging, stargardt's disease, visual cortex, primary visual cortex

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1503-1511. doi:https://doi.org/10.1167/iovs.17-22900

Letters to the Editor

Tear Levels of 8-hydroxy-2′-deoxyguanosine Open Access

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Louis Tong

Tags: deoxyguanosine

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1587. doi:https://doi.org/10.1167/iovs.17-23604

Author Response: Tear Levels of 8-hydroxy-2′-deoxyguanosine Open Access

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Kristina Haworth; Heather Chandler

Tags: deoxyguanosine

Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1588. doi:https://doi.org/10.1167/iovs.17-23682

Erratum

Erratum Open Access

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Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1250. doi:https://doi.org/10.1167/iovs.17-23097a

Erratum Open Access

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Investigative Ophthalmology & Visual Science March 2018, Vol.59, 1278. doi:https://doi.org/10.1167/iovs.18-24089

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