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Anatomy and Pathology/Oncology

The Imbalance of Lymphocyte Subsets and Cytokines: Potential Immunologic Insights Into the Pathogenesis of Chronic Dacryocystitis Open Access
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Xiaoxuan Yang; Lizhen Wang; Lunhao Li; Zhang Yu; Caiwen Xiao
Tags: cytokine, dacryocystitis, imbalance, immunology, lymphocyte subset
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1802-1809. doi:10.1167/iovs.17-23660

Biochemistry and Molecular Biology

Integrin-Linked Kinase Controls Choroidal Neovascularization by Recruitment of Endothelial Progenitor Cells Open Access
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Xiu-Mei Yang; Chun-Guang Duan; Jian Zhang; Xiao-Jie Qu; Yu-Sheng Wang
Tags: choroidal neovascularization, hypoxia, rna, small interfering, stromal cell-derived factor 1, phosphotransferases
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1779-1789. doi:10.1167/iovs.17-22931
Retinoic Acid Maintains Function of Neural Crest–Derived Ocular and Craniofacial Structures in Adult Zebrafish Open Access
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Bahaar Chawla; William Swain; Antionette L. Williams; Brenda L. Bohnsack
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1924-1935. doi:10.1167/iovs.17-22845
Age-Related Changes to Human Tear Composition Open Access
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Alessandra Micera; Antonio Di Zazzo; Graziana Esposito; Rosa Longo; William Foulsham; Roberto Sacco; Roberto Sgrulletta; Stefano Bonini
Tags: aging, enzyme-linked immunosorbent assay, interleukin-6, interleukin-8, proteins
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2024-2031. doi:10.1167/iovs.17-23358
The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction Open Access
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Erlend C. S. Landsend; Øygunn A. Utheim; Hilde R. Pedersen; Hans Christian D. Aass; Neil Lagali; Darlene A. Dartt; Rigmor C. Baraas; Tor P. Utheim
Tags: aniridia, cytokine, meibomian gland, pathophysiology, eye
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2197-2204. doi:10.1167/iovs.18-24027

Clinical and Epidemiologic Research

Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults Open Access
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Soufiane Ajana; Daniela Weber; Catherine Helmer; Bénédicte M. Merle; Wolfgang Stuetz; Jean-François Dartigues; Marie-Bénédicte Rougier; Jean-François Korobelnik; Tilman Grune; Cécile Delcourt; Catherine Féart
Tags: cognition, elderly, lutein, macular pigment, optics
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1828-1835. doi:10.1167/iovs.17-22656
The Economic Burden of Visual Impairment and Comorbid Fatigue: A Cost-of-Illness Study (From a Societal Perspective) Open Access
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Wouter Schakel; Hilde P. A. van der Aa; Christina Bode; Carel T. J. Hulshof; Ger H. M. B. van Rens; Ruth M. A. van Nispen
Tags: fatigue, visual impairment, comorbidity, economics, cost of illness
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1916-1923. doi:10.1167/iovs.17-23224
Long Anterior Lens Zonules and Intraocular Pressure Open Access
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Daniel K. Roberts; Tricia L. Newman; Mary Flynn Roberts; Bruce A. Teitelbaum; Janis E. Winters
Tags: intraocular pressure, lens, crystalline, eye
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2015-2023. doi:10.1167/iovs.17-23705
Direct and Indirect Associations Between Diabetes and Intraocular Pressure: The Singapore Epidemiology of Eye Diseases Study Open Access
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Xiao-Yang Luo; Nicholas Y. Q. Tan; Miao-Li Chee; Yuan Shi; Yih-Chung Tham; Tien Yin Wong; Jie Jin Wang; Ching-Yu Cheng
Tags: diabetes mellitus, diabetes mellitus, type 2, eye diseases, intraocular pressure, singapore
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2205-2211. doi:10.1167/iovs.17-23013

Cornea

Mast Cells Initiate the Recruitment of Neutrophils Following Ocular Surface Injury Open Access
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Srikant K. Sahu; Sharad K. Mittal; William Foulsham; Mingshun Li; Virender S. Sangwan; Sunil K. Chauhan
Tags: cornea, mast cells, neutrophil infiltration, neutrophils, wounds and injuries
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1732-1740. doi:10.1167/iovs.17-23398
High-Mobility Group Box 1 in Dry Eye Inflammation Open Access
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Carolina Lema; Rose Y. Reins; Rachel L. Redfern
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1741-1750. doi:10.1167/iovs.17-23363
Refractive Correction and Biomechanical Strength Following SMILE With a 110- or 160-μm Cap Thickness, Evaluated Ex Vivo by Inflation Test Open Access
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Iben Bach Damgaard; Anders Ivarsen; Jesper Hjortdal
Tags: cornea, economic inflation, postoperative care, preoperative care
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1836-1843. doi:10.1167/iovs.17-23675
Oculomotor Status, Binocular Vision, and Stereoacuity in a Series of Keratoconus Subjects Open Access
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Rosália M. S. Antunes-Foschini; Jean V. A. L. Coutinho; Eduardo M. Rocha; Harley E. A. Bicas
Tags: anisometropia, depth perception, eye, keratoconus, perception
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1869-1877. doi:10.1167/iovs.17-23484
The Relationship of Lid Wiper Epitheliopathy to Ocular Surface Signs and Symptoms Open Access
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Wing Li; Thao N. Yeh; Tiana Leung; Tiffany Yuen; Mariel Lerma; Meng C. Lin
Tags: contact lenses, ocular signs and symptoms, signs and symptoms, questionnaires
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1878-1887. doi:10.1167/iovs.17-23639
Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy Open Access
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Elisabetta Soragni; Lina Petrosyan; Tommy A. Rinkoski; Eric D. Wieben; Keith H. Baratz; Michael P. Fautsch; Joel M. Gottesfeld
Tags: antibodies, cornea, endothelium, hereditary corneal dystrophy, peptides
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1888-1896. doi:10.1167/iovs.17-23265
Alterations of Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress Open Access
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Cem Simsek; Takashi Kojima; Murat Dogru; Kazuo Tsubota
Tags: cornea, dry eye syndromes, mice, neurons, stress
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 1986-1995. doi:10.1167/iovs.17-23743
The Effect of Denatured Lysozyme on Human Corneal Epithelial Cells Open Access
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David J. McCanna; Sarah Oh; Junghee Seo; Chantal Coles-Brennan; Zohra Fadli; Lakshman N. Subbaraman; Lyndon W. Jones
Tags: muramidase, corneal epithelial cells, cytokine
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2006-2014. doi:10.1167/iovs.17-22260
Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization Open Access
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Mingjun Tang; Ying Yang; Jingzhi Yu; Jin Qiu; Pei Chen; Yihui Wu; Qiyun Wang; Zhuojun Xu; Jian Ge; Keming Yu; Jing Zhuang
Tags: alkalies, burns, cxcr4 receptors, mice, corneal neovascularization
Investigative Ophthalmology & Visual Science April 2018, Vol.59, 2133-2141. doi:10.1167/iovs.17-23712

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Reliability and Validity of Gaze-Dependent Functional Vision Space: A Novel Metric Quantifying Visual Function in Infantile Nystagmus Syndrome Open Access
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Tawna L. Roberts; Kristi N. Kester; Richard W. Hertle