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Anatomy and Pathology/Oncology

The Interactions Between Bright Light and Competing Defocus During Emmetropization in Chicks Open Access
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Hui Zheng; Dennis Y. Tse; Xin Tang; Chiho To; Thomas Chuen Lam
Tags: eye, lens (device), lens, crystalline, lighting, myopia
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2932-2943. doi:https://doi.org/10.1167/iovs.17-22973

Clinical and Epidemiologic Research

The Effect of Longer-Term and Exclusive Breastfeeding Promotion on Visual Outcome in Adolescence Open Access
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Christopher G. Owen; Emily Oken; Alicja R. Rudnicka; Rita Patel; Jennifer Thompson; Sheryl L. Rifas-Shiman; Konstatin Vilchuck; Natalia Bogdanovich; Mikhail Hameza; Michael S. Kramer; Richard M. Martin
Tags: breast feeding, vision, adolescent, visual impairment, child
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2670-2678. doi:https://doi.org/10.1167/iovs.17-23211

Cornea

Differential Expression of Coding and Long Noncoding RNAs in Keratoconus-Affected Corneas Open Access
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Mariam Lofty Khaled; Yelena Bykhovskaya; Sarah E. R. Yablonski; Hanzhou Li; Michelle D. Drewry; Inas F. Aboobakar; Amy Estes; X. Raymond Gao; W. Daniel Stamer; Hongyan Xu; R. Rand Allingham; Michael A. Hauser; Yaron S. Rabinowitz; Yutao Liu
Tags: cornea, keratoconus, rna, genes
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2717-2728. doi:https://doi.org/10.1167/iovs.18-24267
Bacterial Coaggregation and Cohesion Among Isolates From Contact Lens Cases Open Access
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Ananya Datta; Fiona Stapleton; Mark D. P. Willcox
Tags: bacteria, contact lens storage case, staphylococcus
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2729-2735. doi:https://doi.org/10.1167/iovs.17-23155
New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies Open Access
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Yulia Kaluzhny; Miriam W. Kinuthia; Thoa Truong; Allison M. Lapointe; Patrick Hayden; Mitchell Klausner
Tags: body tissue, cornea, ophthalmic agents, corneal epithelium, permeability
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2880-2898. doi:https://doi.org/10.1167/iovs.18-23944
PEDF Reduces the Severity of Herpetic Simplex Keratitis in Mice Open Access
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Xiao Tian; Tongsong Wang; Songmei Zhang; Qian Wang; Xiaoli Hu; Cheng Ge; Lixin Xie; Qingjun Zhou
Tags: cornea, human herpesvirus 1, keratitis, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2923-2931. doi:https://doi.org/10.1167/iovs.18-23942
Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas Open Access
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James W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravarti
Tags: collagen, cornea, keratoconus, keratocytes, proteins
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2977-2986. doi:https://doi.org/10.1167/iovs.18-24367
Effects of Corneal Hydration on Brillouin Microscopy In Vivo Open Access
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Peng Shao; Theo G. Seiler; Amira M. Eltony; Antoine Ramier; Sheldon J. J. Kwok; Giuliano Scarcelli; Roberto Pineda II; Seok-Hyun Yun
Tags: cornea, intravital microscopy, water, suidae
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3020-3027. doi:https://doi.org/10.1167/iovs.18-24228
Directed Differentiation of Human Corneal Endothelial Cells From Human Embryonic Stem Cells by Using Cell-Conditioned Culture Media Open Access
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Xiaoniao Chen; Lingling Wu; Zongjin Li; Ying Dong; Xuetao Pei; Yifei Huang; Liqiang Wang
Tags: conditioning (psychology), cornea, culture media, culture media, conditioned, embryonic stem cells
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3028-3036. doi:https://doi.org/10.1167/iovs.17-23627
Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1 Open Access
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Nelson S. Winkler; Margherita Milone; Jennifer M. Martinez-Thompson; Harish Raja; Ross A. Aleff; Sanjay V. Patel; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz
Tags: endothelium, hereditary corneal dystrophy, myotonic dystrophy, genes, rna
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3053-3057. doi:https://doi.org/10.1167/iovs.17-23160
Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome Open Access
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Agnė Žiniauskaitė; Symantas Ragauskas; Jenni J. Hakkarainen; Cadmus C. Rich; Rudolf Baumgartner; Giedrius Kalesnykas; David S. Albers; Simon Kaja
Tags: cyclosporine, dry eye syndromes, eye, keratoconjunctivitis sicca, mice
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3088-3093. doi:https://doi.org/10.1167/iovs.18-24432
Effects of Topical Mucolytic Agents on the Tears and Ocular Surface: A Plausible Animal Model of Mucin-Deficient Dry Eye Open Access
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Xiangzhe Li; Boram Kang; In Ho Woo; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
Tags: animal model, dry eye syndromes, mucins, mucolytic agents, tear film finding
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3104-3114. doi:https://doi.org/10.1167/iovs.18-23860

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Optic Nerve Sheath Tethering in Adduction Occurs in Esotropia and Hypertropia, But Not in Exotropia Open Access
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Soh Youn Suh; Robert A. Clark; Joseph L. Demer
Tags: adduction, esotropia, exotropia, eye, hypertropia
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2899-2904. doi:https://doi.org/10.1167/iovs.18-24305
Tumor Necrosis Factor Inhibition in the Acute Management of Traumatic Optic Neuropathy Open Access
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Brian C. Tse; Galina Dvoriantchikova; Wensi Tao; Ryan A. Gallo; John Y. Lee; Steven Pappas; Roberta Brambilla; Dmitry Ivanov; David T. Tse; Daniel Pelaez
Tags: optic nerve injuries, tumor necrosis factors, wounds and injuries, etanercept
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2905-2912. doi:https://doi.org/10.1167/iovs.18-24431
A Subset of Palisade Endings Only in the Medial and Inferior Rectus Muscle in Monkey Contain Calretinin Open Access
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Karoline Lienbacher; Seiji Ono; Jérome Fleuriet; Michael Mustari; Anja K. E. Horn
Tags: calretinin, medial rectus muscle, muscle of orbit, inferior rectus muscle, cercopithecidae
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2944-2954. doi:https://doi.org/10.1167/iovs.18-24322

Genetics

Genotype and Phenotype Spectrum of FRMD7-Associated Infantile Nystagmus Syndrome Open Access
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Jae-Hwan Choi; Jae-Ho Jung; Eun Hye Oh; Jin-Hong Shin; Hyang-Sook Kim; Je Hyun Seo; Seo Young Choi; Min-Ji Kim; Hee Young Choi; Changwook Lee; Kwang-Dong Choi
Tags: genotype, mutation, pathologic nystagmus, phenotype, syndrome
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3181-3188. doi:https://doi.org/10.1167/iovs.18-24207

Glaucoma

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles Open Access
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Yeni H. Yücel; Kirsten Cardinell; Shireen Khattak; Xun Zhou; Michael Lapinski; Fang Cheng; Neeru Gupta
Tags: diagnostic imaging, drainage of lymphatics, eye, injections, nanoparticles
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2699-2707. doi:https://doi.org/10.1167/iovs.17-22850
The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration Open Access
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Joana Galvao; Keiichiro Iwao; Akintomide Apara; Yan Wang; Masoumeh Ashouri; Tejas Nimish Shah; Murray Blackmore; Noelia J. Kunzevitzky; Darcie L. Moore; Jeffrey L. Goldberg
Tags: axon, genes
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2736-2747. doi:https://doi.org/10.1167/iovs.17-23319
Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression Open Access
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Mark Christopher; Akram Belghith; Robert N. Weinreb; Christopher Bowd; Michael H. Goldbaum; Luke J. Saunders; Felipe A. Medeiros; Linda M. Zangwill
Tags: glaucoma, retinal nerve fiber layer, optical coherence tomography, unsupervised machine learning
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2748-2756. doi:https://doi.org/10.1167/iovs.17-23387
Mapping the Central 10° Visual Field to the Optic Nerve Head Using the Structure–Function Relationship Open Access
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Yuri Fujino; Hiroshi Murata; Masato Matsuura; Mieko Yanagisawa; Nobuyuki Shoji; Kenji Inoue; Junkichi Yamagami; Ryo Asaoka
Tags: optic disk, visual fields, eye
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2801-2807. doi:https://doi.org/10.1167/iovs.17-23485
Peripapillary Retinoschisis in Glaucoma: Association With Progression and OCT Signs of Müller Cell Involvement Open Access
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Brad Fortune; Kelly N. Ma; Stuart K. Gardiner; Shaban Demirel; Steven L. Mansberger
Tags: eye, glaucoma, retinoschisis, retinal nerve fiber layer, retina
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2818-2827. doi:https://doi.org/10.1167/iovs.18-24160
VIP Regulates Morphology and F-Actin Distribution of Schlemm's Canal in a Chronic Intraocular Pressure Hypertension Model via the VPAC2 Receptor Open Access
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Liwen Chen; Mu Li; Zhaoxia Luo; Xiaoqin Yan; Ke Yao; Yin Zhao; Hong Zhang
Tags: actins, hypertension, intraocular pressure, morphology, schlemm's canal
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2848-2860. doi:https://doi.org/10.1167/iovs.17-22688
microRNA Profiling in Glaucoma Eyes With Varying Degrees of Optic Neuropathy by Using Next-Generation Sequencing Open Access
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Yaoming Liu; Yang Chen; Yayi Wang; Xinyu Zhang; Kai Gao; Shida Chen; Xiulan Zhang
Tags: eye, glaucoma, massively-parallel genome sequencing, micrornas, open-angle glaucoma
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2955-2966. doi:https://doi.org/10.1167/iovs.17-23599
Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera Open Access
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Alexandra Gogola; Ning-Jiun Jan; Bryn Brazile; Po Lam; Kira L. Lathrop; Kevin C. Chan; Ian A. Sigal
Tags: collagen, cornea, eye, sclera
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2987-2998. doi:https://doi.org/10.1167/iovs.17-23474
YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis Open Access
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Akiko Futakuchi; Toshihiro Inoue; Fan-Yan Wei; Miyuki Inoue-Mochita; Tomokazu Fujimoto; Kazuhito Tomizawa; Hidenobu Tanihara
Tags: conjunctiva, fibroblasts, fibrosis, proteins, signal transduction
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3069-3078. doi:https://doi.org/10.1167/iovs.18-24258
Trichostatin A Ameliorates Conjunctival Fibrosis in a Rat Trabeculectomy Model Open Access
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Mi Sun Sung; Gwang Hyeon Eom; Soo Jin Kim; So Young Kim; Hwan Heo; Sang Woo Park
Tags: blister, conjunctiva, eyedrops, fibrosis, postoperative care
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3115-3123. doi:https://doi.org/10.1167/iovs.18-23826
A Novel Tree Shrew (Tupaia belangeri) Model of Glaucoma Open Access
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Brian C. Samuels; John T. Siegwart; Wenjie Zhan; Lisa Hethcox; Melissa Chimento; Ryan Whitley; J. Crawford Downs; Christopher A. Girkin
Tags: glaucoma, intraocular pressure, tupaia, tupaiidae, eye
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3136-3143. doi:https://doi.org/10.1167/iovs.18-24261
The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head Open Access
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Dan E. Midgett; Joan L. Jefferys; Harry A. Quigley; Thao D. Nguyen
Tags: economic inflation, glycosaminoglycans, optic disk, enzymes, catabolism
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3144-3154. doi:https://doi.org/10.1167/iovs.18-23845

Immunology and Microbiology

MyD88 Deficiency Protects Against Dry Eye–Induced Damage Open Access
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Rose Y. Reins; Carolina Lema; Justin Courson; Carolina M. E. Kunnen; Rachel L. Redfern
Tags: dry eye syndromes, mice, myd88 gene, signal transduction, cytokine
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2967-2976. doi:https://doi.org/10.1167/iovs.17-23397

Lens

Aqp0a Regulates Suture Stability in the Zebrafish Lens Open Access
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Irene Vorontsova; Ines Gehring; James E. Hall; Thomas F. Schilling
Tags: lens (device), lens, crystalline, sutures, zebrafish, cell nucleus
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2869-2879. doi:https://doi.org/10.1167/iovs.18-24044

Physiology and Pharmacology

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro Open Access
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Brittany J. Carr; Koichiro Mihara; Rithwik Ramachandran; Mahmoud Saifeddine; Neil M. Nathanson; William K. Stell; Morley D. Hollenberg
Tags: adrenergic receptor, antagonists, atropine, muscarinic antagonists, myopia
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2778-2791. doi:https://doi.org/10.1167/iovs.17-22562

Retina

CD160 Expression in Retinal Vessels Is Associated With Retinal Neovascular Diseases Open Access
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Adrien Henry; Camille Boulagnon-Rombi; Thierry Menguy; Jérôme Giustiniani; Christian Garbar; Corinne Mascaux; Marc Labrousse; Corentin Milas; Coralie Barbe; Armand Bensussan; Vincent Durlach; Carl Arndt
Tags: eye, retinal vessels, donors
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2679-2686. doi:https://doi.org/10.1167/iovs.18-24021
Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion Open Access
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Andrew Winegarner; Taku Wakabayashi; Yoko Fukushima; Tatsuhiko Sato; Chikako Hara-Ueno; Caleb Busch; Issei Nishiyama; Nobuhiko Shiraki; Kaori Sayanagi; Kentaro Nishida; Hirokazu Sakaguchi; Kohji Nishida
Tags: anti-vascular endothelial growth factor therapy, retinal vasculature, retinal vein occlusion, visual acuity, endothelial growth factors
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2708-2716. doi:https://doi.org/10.1167/iovs.17-23437
Omega-3 Fatty Acids Supplementation: Therapeutic Potential in a Mouse Model of Stargardt Disease Open Access
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Ekatherine Prokopiou; Panagiotis Kolovos; Maria Kalogerou; Anastasia Neokleous; Orthodoxia Nicolaou; Kleitos Sokratous; Kyriacos Kyriacou; Tassos Georgiou
Tags: lipofuscin, mice, omega-3 fatty acids, stargardt's disease, granules
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2757-2767. doi:https://doi.org/10.1167/iovs.17-23523
Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics Open Access
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Xiaofei Wang; Clarence Ken Guan Teoh; Anita S. Y. Chan; Sathiyan Thangarajoo; Jost B. Jonas; Michaël J. A. Girard
Tags: biomechanics, body tissue, bruch's basal membrane, choroid, eye
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2808-2817. doi:https://doi.org/10.1167/iovs.17-22069
Outer Plexiform Layer Elevations as a Marker for Prior Ocular Attacks in Patients With Behcet's Disease Open Access
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Ai Kido; Akihito Uji; Satoshi Morooka; Yoshimasa Kuroda; Shigeta Arichika; Tadamichi Akagi; Akitaka Tsujikawa
Tags: behcet syndrome, eye, photoreceptors
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2828-2832. doi:https://doi.org/10.1167/iovs.18-24348
Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses Open Access
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Merve Inanc Tekin; Mehmet Ali Sekeroglu; Canan Demirtas; Kemal Tekin; Sibel Doguizi; Serdar Bayraktar; Pelin Yilmazbas
Tags: age-related macular degeneration, brain-derived neurotrophic factor, hypertension
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2833-2840. doi:https://doi.org/10.1167/iovs.18-24030
Analysis of Anatomic and Functional Measures in X-Linked Retinoschisis Open Access
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Catherine A. Cukras; Laryssa A. Huryn; Brett G. Jeffrey; Amy Turriff; Paul A. Sieving
Tags: electroretinography, eye, functional measures, natural history, visual acuity
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2841-2847. doi:https://doi.org/10.1167/iovs.17-23297
Deep Learning for Predicting Refractive Error From Retinal Fundus Images Open Access
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Avinash V. Varadarajan; Ryan Poplin; Katy Blumer; Christof Angermueller; Joe Ledsam; Reena Chopra; Pearse A. Keane; Greg S. Corrado; Lily Peng; Dale R. Webster
Tags: attention, learning, refractive errors
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2861-2868. doi:https://doi.org/10.1167/iovs.18-23887
Projection-Resolved OCT Angiography of Microvascular Changes in Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy Open Access
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Sally Chu; Peter L. Nesper; Brian T. Soetikno; Sophie J. Bakri; Amani A. Fawzi
Tags: acute macular neuroretinopathy, angiogram, blood capillaries, eye, fluid flow
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2913-2922. doi:https://doi.org/10.1167/iovs.18-24112
Grade of Cataract and Its Influence on Measurement of Macular Pigment Optical Density Using Autofluorescence Imaging Open Access
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Akira Obana; Yuko Gohto; Hiroyuki Sasano; Werner Gellermann; Mohsen Sharifzadeh; Takahiko Seto; Paul S. Bernstein
Tags: autofluorescence, cataract, diagnostic imaging, eye, macular pigment
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3011-3019. doi:https://doi.org/10.1167/iovs.17-23699
Phenotype Variations Caused by Mutations in the RP1L1 Gene in a Large Mainly German Cohort Open Access
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Ditta Zobor; Gergely Zobor; Stephanie Hipp; Britta Baumann; Nicole Weisschuh; Saskia Biskup; Ieva Sliesoraityte; Eberhart Zrenner; Susanne Kohl
Tags: cohort studies, genes, german, mutation, phenotype
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3041-3052. doi:https://doi.org/10.1167/iovs.18-24033
Potential Role of Zinc Dyshomeostasis in Matrix Metalloproteinase-2 and -9 Activation and Photoreceptor Cell Death in Experimental Retinal Detachment Open Access
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Jeong A Choi; Yoon Jeon Kim; Bo-Ra Seo; Jae-Young Koh; Young Hee Yoon
Tags: gelatinase a, mice, photoreceptors, zinc, retinal detachment
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3058-3068. doi:https://doi.org/10.1167/iovs.17-23502
The Relationship Between Blue-Fundus Autofluorescence and Optical Coherence Tomography in Eyes With Lamellar Macular Holes Open Access
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Roberto dell'Omo; Denise Vogt; Ricarda G. Schumann; Serena De Turris; Gianni Virgili; Giovanni Staurenghi; Matteo Cereda; Ciro Costagliola; Siegfried G. Priglinger; Ferdinando Bottoni
Tags: autofluorescence, eye, macular holes, optical coherence tomography, diameter
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3079-3087. doi:https://doi.org/10.1167/iovs.18-24379
Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) of Macular Pigment Open Access
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Lydia Sauer; Karl M. Andersen; Binxing Li; Rebekah H. Gensure; Martin Hammer; Paul S. Bernstein
Tags: diagnostic imaging, macular pigment, fluorescence, ophthalmoscopy, eye
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3094-3103. doi:https://doi.org/10.1167/iovs.18-23886
Automated Diagnosis and Grading of Diabetic Retinopathy Using Optical Coherence Tomography Open Access
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Harpal Singh Sandhu; Ahmed Eltanboly; Ahmed Shalaby; Robert S. Keynton; Schlomit Schaal; Ayman El-Baz
Tags: diabetic retinopathy, optical coherence tomography, nonproliferative diabetic retinopathy, diabetes mellitus, retina
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3155-3160. doi:https://doi.org/10.1167/iovs.17-23677
Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease Open Access
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Sally S. Ong; Prithvi Mruthyunjaya; Sandra Stinnett; Lejla Vajzovic; Cynthia A. Toth
Tags: diagnostic imaging, exudative retinopathy, eye, spectral domain-optical coherence tomography, visual acuity
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3161-3174. doi:https://doi.org/10.1167/iovs.18-24109
Fluorescein Leakage and Optical Coherence Tomography Features of Choroidal Neovascularization Secondary to Pathologic Myopia Open Access
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Maurizio Battaglia Parodi; Pierluigi Iacono; Francesco Romano; Francesco Bandello
Tags: choroidal neovascularization, myopic macular degeneration, spectral domain-optical coherence tomography, fluorescein, optical coherence tomography
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3175-3180. doi:https://doi.org/10.1167/iovs.17-23640

Retinal Cell Biology

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models Open Access
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Thierry Menguy; Anne Briaux; Elisabeth Jeunesse; Jérôme Giustiniani; Alexandre Calcei; Thierry Guyon; Jacques Mizrahi; Hélène Haegel; Vanessa Duong; Vincent Soler; Pierre Brousset; Armand Bensussan; Isabelle Raymond Letron; Philippe Le Bouteiller
Tags: bevacizumab, choroidal neovascularization, coefficient of determination, monoclonal antibodies, neovascularization, pathologic
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2687-2698. doi:https://doi.org/10.1167/iovs.18-24024
Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin Open Access
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Chad A. Galloway; Sonal Dalvi; Audra M. A. Shadforth; Shuko Suzuki; Molly Wilson; David Kuai; Ali Hashim; Leslie A. MacDonald; David M. Gamm; Damien G. Harkin; Ruchira Singh
Tags: bruch's basal membrane, fibroins, prostheses, tissue membrane, proteins
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2792-2800. doi:https://doi.org/10.1167/iovs.17-23157
D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo Open Access
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Bruce A. Berkowitz; Robert H. Podolsky; Benjamin Farrell; Hojun Lee; Christopher Trepanier; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Timothy S. Kern; Robin Roberts
Tags: diltiazem, magnetic resonance imaging, mice, oxidative stress, rod photoreceptors
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2999-3010. doi:https://doi.org/10.1167/iovs.18-23829

Visual Neuroscience

Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease Open Access
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Atsuro Uchida; Jagan A. Pillai; Robert Bermel; Aaron Bonner-Jackson; Alexander Rae-Grant; Hubert Fernandez; James Bena; Stephen E. Jones; James B. Leverenz; Sunil K. Srivastava; Justis P. Ehlers
Tags: alzheimer's disease, neurodegenerative disorders, parkinson disease, spectral domain-optical coherence tomography, dementia
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 2768-2777. doi:https://doi.org/10.1167/iovs.17-23240
Systemic 7,8-Dihydroxyflavone Treatment Protects Immature Retinas Against Hypoxic-Ischemic Injury via Müller Glia Regeneration and MAPK/ERK Activation Open Access
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Hsiu-Mei Huang; Chao-Ching Huang; Meng-Han Tsai; Yi-Chieh Poon; Ying-Chao Chang
Tags: retina, wounds and injuries, hypoxia, ischemia, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3124-3135. doi:https://doi.org/10.1167/iovs.18-23792

Letters to the Editor

Axial Scaling Is Independent of Ocular Magnification in OCT Images Open Access
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Alexander E. Salmon; Benjamin S. Sajdak; Farid Atry; Joseph Carroll
Tags: magnification, eye
Investigative Ophthalmology & Visual Science June 2018, Vol.59, 3037-3040. doi:https://doi.org/10.1167/iovs.17-23549
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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