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Biochemistry and Molecular Biology

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells Open Access
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David W. Sant; Vladimir Camarena; Sushmita Mustafi; Yiwen Li; Zachary Wilkes; Derek Van Booven; Rong Wen; Gaofeng Wang
Tags: retinal pigment cell, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3608-3618. doi:https://doi.org/10.1167/iovs.18-24101
The Role of the RhoA/ROCK Signaling Pathway in Mechanical Strain-Induced Scleral Myofibroblast Differentiation Open Access
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Ying Yuan; Min Li; Chi Ho To; Thomas Chuen Lam; Peng Wang; Yunjie Yu; Qingzhong Chen; Xiaojun Hu; Bilian Ke
Tags: fibroblasts, myofibroblasts, rhoa gtp-binding protein, sclera, signal pathway
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3619-3629. doi:https://doi.org/10.1167/iovs.17-23580

Clinical and Epidemiologic Research

A Cross-Sectional and Longitudinal Study of Retinal Sensitivity in RPE65-Associated Leber Congenital Amaurosis Open Access
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Neruban Kumaran; Gary S. Rubin; Angelos Kalitzeos; Kaoru Fujinami; James W. B. Bainbridge; Richard G. Weleber; Michel Michaelides
Tags: contrast sensitivity, eye, genotype, leber's amaurosis, longitudinal studies
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3330-3339. doi:https://doi.org/10.1167/iovs.18-23873
Distribution and Trends in Corneal Thickness Parameters in a Large Population-Based Multicenter Study of Young Chinese Adults Open Access
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Ruijue Ma; Yuanyuan Liu; Lin Zhang; Yulin Lei; Jie Hou; Zhengwei Shen; Xianglong Yi; Yan Wang
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3366-3374. doi:https://doi.org/10.1167/iovs.18-24332

Cornea

Effect of Nitric Oxide on Acanthamoeba castellanii Open Access
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Bora Yim; Joo-Hee Park; Hyejoong Jeong; Jinkee Hong; Martha Kim; Minwook Chang; Roy S. Chuck; Choul Yong Park
Tags: acanthamoeba, acanthamoeba castellanii, cysts, nitric oxide, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3239-3248. doi:https://doi.org/10.1167/iovs.18-23786
Hyperosmotic Stress–Induced TRPM2 Channel Activation Stimulates NLRP3 Inflammasome Activity in Primary Human Corneal Epithelial Cells Open Access
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Qinxiang Zheng; Qiufan Tan; Yueping Ren; Peter S. Reinach; Ling Li; Chaoxiang Ge; Jia Qu; Wei Chen
Tags: clusterin, inflammasomes, nlr family, pyrin domain-containing 3 protein, stress, corneal epithelial cells
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3259-3268. doi:https://doi.org/10.1167/iovs.18-23965
Activation of Dendritic Cells in Dry Eye Mouse Model Open Access
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Shinji Maruoka; Muneo Inaba; Nahoko Ogata
Tags: dendritic cells, dry eye syndromes, mice, scopolamine, cornea
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3269-3277. doi:https://doi.org/10.1167/iovs.17-22550
Oxidative Stress Suppresses Cellular Autophagy in Corneal Epithelium Open Access
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Yuanyuan Yin; Rongrong Zong; Xiaorui Bao; Xiling Zheng; Huixia Cui; Zuguo Liu; Yueping Zhou
Tags: autophagy, cornea, corneal epithelium, hydrogen peroxide, oxidative stress
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3286-3293. doi:https://doi.org/10.1167/iovs.18-24057
Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8 Open Access
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Andrew D. Pucker; Bradley E. Dougherty; Lisa A. Jones-Jordan; Justin T. Kwan; Carolina M. E. Kunnen; Sruthi Srinivasan
Tags: questionnaires, psychometrics, self-report, dry eye syndromes
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3307-3313. doi:https://doi.org/10.1167/iovs.18-24016
Safety and Feasibility of Intrastromal Injection of Cultivated Human Corneal Stromal Keratocytes as Cell-Based Therapy for Corneal Opacities Open Access
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Gary Hin-Fai Yam; Matthias Fuest; Nur Zahirah Binte M. Yusoff; Tze-Wei Goh; Francisco Bandeira; Melina Setiawan; Xin-Yi Seah; Nyein-Chan Lwin; Tisha P. Stanzel; Hon-Shing Ong; Jodhbir S. Mehta
Tags: cornea, corneal opacity, injections
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3340-3354. doi:https://doi.org/10.1167/iovs.17-23575
0.005% Preservative-Free Latanoprost Induces Dry Eye-Like Ocular Surface Damage via Promotion of Inflammation in Mice Open Access
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Yiran Yang; Caihong Huang; Xiang Lin; Yang Wu; Weijie Ouyang; Liying Tang; Sihao Ye; Yuhong Wang; Wei Li; Xiaobo Zhang; Zuguo Liu
Tags: latanoprost, eyedrops, administration, topical, mice, inflammation
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3375-3384. doi:https://doi.org/10.1167/iovs.18-24013
Inhibition of Human Corneal Myofibroblast Formation Open Access
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Xiaoqing Guo; Sriniwas Sriram; Jennifer A. Tran; Audrey E. K. Hutcheon; James D. Zieske
Tags: cornea, myofibroblasts, proteins, fibrosis, signal transduction
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3511-3520. doi:https://doi.org/10.1167/iovs.18-24239
Tear Film Proteomics Reveal Important Differences Between Patients With and Without Ocular GvHD After Allogeneic Hematopoietic Cell Transplantation Open Access
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Nadine Gerber-Hollbach; Kim Plattner; Olivia E. O'Leary; Paul Jenoe; Suzette Moes; Beatrice Drexler; Andreas Schoetzau; Jörg P. Halter; David Goldblum
Tags: graft-versus-host disease, proteins, hematopoietic stem cell transplantation, tear film finding, proteomics
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3521-3530. doi:https://doi.org/10.1167/iovs.18-24433
Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells Open Access
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Min He; Marit Lippestad; Dayu Li; Robin R. Hodges; Tor P. Utheim; Darlene A. Dartt
Tags: bodily secretions, conjunctiva, epidermal growth factor receptors, goblet cells, histamine
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3543-3553. doi:https://doi.org/10.1167/iovs.18-2476
Keratocyte Density Is Reduced and Related to Corneal Nerve Damage in Diabetic Neuropathy Open Access
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Alise Kalteniece; Maryam Ferdousi; Shazli Azmi; Andrew Marshall; Handrean Soran; Rayaz A. Malik
Tags: cornea, diabetic neuropathies, keratocytes, nerve injuries, neurons
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3584-3590. doi:https://doi.org/10.1167/iovs.18-23889
Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage Open Access
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Bing Wang; Pui-Kai Li; Jian-xing Ma; Danyang Chen
Tags: angiogenesis inhibitors, cornea, corneal neovascularization, diabetes mellitus, rats
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3630-3642. doi:https://doi.org/10.1167/iovs.18-24015
Corneal Collagen Cross-Linking With Riboflavin and UVA Regulates Hemangiogenesis and Lymphangiogenesis in Rats Open Access
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Yirui Zhu; Ling Li; Peter S. Reinach; Yun Li; Chaoxiang Ge; Jia Qu; Wei Chen
Tags: cornea, corneal collagen cross-linking, lymphangiogenesis, riboflavin, sutures
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3702-3712. doi:https://doi.org/10.1167/iovs.17-23036
Hyaluronan Regulates Eyelid and Meibomian Gland Morphogenesis Open Access
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Mingxia Sun; Sudan Puri; Geraint J. Parfitt; Nadine Mutoji; Vivien J. Coulson-Thomas
Tags: eyelid, hyaluronan, mice, morphogenesis, meibomian gland
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3713-3727. doi:https://doi.org/10.1167/iovs.18-24292
Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration Open Access
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Ajay Kumar; Yi Xu; Enzhi Yang; Yiqin Du
Tags: cornea, mesenchymal stem cells, keratocytes, stem cells, wound healing
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3728-3738. doi:https://doi.org/10.1167/iovs.18-23824
Modulating Contact Lens Discomfort With Anti-Inflammatory Approaches: A Randomized Controlled Trial Open Access
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Laura E. Downie; Anne Gad; Chinn Yi Wong; John Henry V. Gray; Weiguang Zeng; David C. Jackson; Algis J. Vingrys
Tags: anti-inflammatory agents, contact lenses, inflammation, omega-3 fatty acids, placebos
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3755-3766. doi:https://doi.org/10.1167/iovs.18-24758

Genetics

The Common ABCA4 Variant p.Asn1868Ile Shows Nonpenetrance and Variable Expression of Stargardt Disease When Present in trans With Severe Variants Open Access
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Esmee H. Runhart; Riccardo Sangermano; Stéphanie S. Cornelis; Joke B. G. M. Verheij; Astrid S. Plomp; Camiel J. F. Boon; Dorien Lugtenberg; Susanne Roosing; Nathalie M. Bax; Ellen A. W. Blokland; Marlie H. M. Jacobs-Camps; Saskia D. van der Velde-Visser; Jan-Willem R. Pott; Klaus Rohrschneider; Alberta A. H. J. Thiadens; Caroline C. W. Klaver; L. Ingeborgh van den Born; Carel B. Hoyng; Frans P. M. Cremers
Tags: penetrance, genetic, stargardt's disease, proband, alleles, age of onset
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3220-3231. doi:https://doi.org/10.1167/iovs.18-23881

Glaucoma

Does Glaucoma Alter Eye Movements When Viewing Images of Natural Scenes? A Between-Eye Study Open Access
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Daniel S. Asfaw; Pete R. Jones; Vera M. Mönter; Nicholas D. Smith; David P. Crabb
Tags: eye, eye movement, glaucoma, natural scenes, saccades
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3189-3198. doi:https://doi.org/10.1167/iovs.18-23779
Influence of the Water-Drinking Test on Intraocular Pressure, Schlemm's Canal, and Autonomic Nervous System Activity Open Access
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Wei Chen; Liugui Chen; Zhiqi Chen; Yan Xiang; Shiliang Liu; Hong Zhang; Junming Wang
Tags: autonomic nervous system, intraocular pressure, schlemm's canal, water drinking, heart failure
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3232-3238. doi:https://doi.org/10.1167/iovs.18-23909
Parapapillary Beta Zone and Gamma Zone in a Healthy Population: The Beijing Eye Study 2011 Open Access
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Qi Zhang; Ya Xing Wang; Wen Bin Wei; Liang Xu; Jost B. Jonas
Tags: beijing, eye, optic disk, bruch's basal membrane, prevalence
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3320-3329. doi:https://doi.org/10.1167/iovs.18-24141
Selective Early Glial Reactivity in the Visual Pathway Precedes Axonal Loss, Following Short-Term Cerebrospinal Fluid Pressure Reduction Open Access
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Xiao Xia Li; Zheng Zhang; Hui Yang Zeng; Shen Wu; Lu Liu; Jing Xue Zhang; Qian Liu; Di Ya Yang; Ning Li Wang
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3394-3404. doi:https://doi.org/10.1167/iovs.17-22232
Visual Performance as a Function of Luminance in Glaucoma: The De Vries-Rose, Weber's, and Ferry-Porter's Law Open Access
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Ronald A. J. M. Bierings; Marije H. de Boer; Nomdo M. Jansonius
Tags: glaucoma, luminance, statutes and laws
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3416-3423. doi:https://doi.org/10.1167/iovs.17-22497
Anatomic Evidence for Information Exchange between Primary Afferent Sensory Neurons Innervating the Anterior Eye Chamber and the Dura Mater in Rat Open Access
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Haixia Liu; Xutao Zhu; Yun Ling; Xiaobin He; Lei Pei; Zhidan Zhang; Fang Yang; Fuqiang Xu
Tags: dura mater, eye, neurons, neurons, afferent, rats
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3424-3430. doi:https://doi.org/10.1167/iovs.18-24308
The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow Open Access
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Naoki Kiyota; Yukihiro Shiga; Kohei Ichinohasama; Masayuki Yasuda; Naoko Aizawa; Kazuko Omodaka; Naoto Honda; Hiroshi Kunikata; Toru Nakazawa
Tags: intraocular pressure, optic disk, vascular flow, mydriasis, body tissue
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3488-3496. doi:https://doi.org/10.1167/iovs.18-23872
Dynamic Changes in Schlemm Canal and Iridocorneal Angle Morphology During Accommodation in Children With Healthy Eyes: A Cross-Sectional Cohort Study Open Access
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Moritz Claudius Daniel; Adam M. Dubis; Ana Quartilho; Huda Al-Hayouti; Sir Peng Tee Khaw; Maria Theodorou; Annegret Dahlmann-Noor
Tags: child, cohort studies, eye, language morphology, morphology
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3497-3502. doi:https://doi.org/10.1167/iovs.17-23189
Diagnostic Accuracy of Three-Dimensional Neuroretinal Rim Thickness for Differentiation of Myopic Glaucoma From Myopia Open Access
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Yong Woo Kim; Ki Ho Park
Tags: eye, false-positive results, glaucoma, myopia, neuroretinal rim
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3655-3666. doi:https://doi.org/10.1167/iovs.18-24283
Differences in the Relation Between Perimetric Sensitivity and Variability Between Locations Across the Visual Field Open Access
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Stuart K. Gardiner
Tags: perimetry, visual fields, eye, glaucoma
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3667-3674. doi:https://doi.org/10.1167/iovs.18-24303
Peripapillary Choroidal Vascularity Index in Glaucoma—A Comparison Between Spectral-Domain OCT and OCT Angiography Open Access
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Jun Woo Park; Min Hee Suh; Rupesh Agrawal; Neha Khandelwal
Tags: angiogram, antidepressive agents, tricyclic, cortical blindness, eye, glaucoma
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3694-3701. doi:https://doi.org/10.1167/iovs.18-24315
Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation Open Access
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Elias Pavlatos; Yanhui Ma; Keyton Clayson; Xueliang Pan; Jun Liu
Tags: intraocular pressure, optic disk, sclera, eye, ultrasonography
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3779-3788. doi:https://doi.org/10.1167/iovs.18-24462

Lens

Wnt5a Contributes to the Differentiation of Human Embryonic Stem Cells into Lentoid Bodies Through the Noncanonical Wnt/JNK Signaling Pathway Open Access
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Chenlu Han; Jinyan Li; Chunxiao Wang; Hong Ouyang; Xiaoyan Ding; Yizhi Liu; Shuyi Chen; Lixia Luo
Tags: wnt-5a protein, lens, crystalline, lens (device)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3449-3460. doi:https://doi.org/10.1167/iovs.18-23902
Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery Open Access
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Leonid M. Zukin; Michelle G. Pedler; Sergio Groman-Lupa; Mina Pantcheva; David A. Ammar; J. Mark Petrash
Tags: aldehyde reductase, cataract surgery, epithelial to mesenchymal transition, genetics, opacification
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3591-3598. doi:https://doi.org/10.1167/iovs.18-23935

Multidisciplinary Ophthalmic Imaging

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT Open Access
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Chen Xin; Shaozhen Song; Murray Johnstone; Ningli Wang; Ruikang K. Wang
Tags: motion, physicians' health study, trabecular meshwork, united states public health service, eye
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3675-3681. doi:https://doi.org/10.1167/iovs.17-23579

Physiology and Pharmacology

Characterization and Regulation of Gap Junctions in Porcine Ciliary Epithelium Open Access
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Stanley Ka-Lok Li; Sze-Wan Shan; Hoi-Lam Li; Angela King-Wah Cheng; Feng Pan; Shea-Ping Yip; Mortimer M. Civan; Chi-Ho To; Chi-Wai Do
Tags: ciliary epithelium, connexin 43, gap junction protein, suidae, protein isoforms
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3461-3468. doi:https://doi.org/10.1167/iovs.18-24682
TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye Open Access
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David A. Bereiter; Mostafeezur Rahman; Randall Thompson; Pannaporn Stephenson; Hiroto Saito
Tags: dry eye syndromes, rats, trpv1 receptor, eye, capsaicin
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3739-3746. doi:https://doi.org/10.1167/iovs.18-24304

Retina

Prediction of Individual Disease Conversion in Early AMD Using Artificial Intelligence Open Access
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Ursula Schmidt-Erfurth; Sebastian M. Waldstein; Sophie Klimscha; Amir Sadeghipour; Xiaofeng Hu; Bianca S. Gerendas; Aaron Osborne; Hrvoje Bogunović
Tags: artificial intelligence, choroidal neovascularization, diagnostic imaging, drusen, eye
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3199-3208. doi:https://doi.org/10.1167/iovs.18-24106
Cone Vision Changes in the Enhanced S-Cone Syndrome Caused by NR2E3 Gene Mutations Open Access
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Alexandra V. Garafalo; Giacomo Calzetti; Artur V. Cideciyan; Alejandro J. Roman; Supna Saxena; Alexander Sumaroka; Windy Choi; Alan F. Wright; Samuel G. Jacobson
Tags: mutation, retinal cone, syndrome, vision, visual fields
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3209-3219. doi:https://doi.org/10.1167/iovs.18-24518
Ultra-Wide-Field Fluorescein Angiography–Guided Normalization of Ischemic Index Calculation in Eyes With Retinal Vein Occlusion Open Access
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Kang Wang; Khalil Ghasemi Falavarjani; Muneeswar G. Nittala; Min Sagong; Charles C. Wykoff; Jano van Hemert; Michael Ip; SriniVas R. Sadda
Tags: eye, fluorescein angiography, ischemia, retinal vein occlusion, retina
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3278-3285. doi:https://doi.org/10.1167/iovs.18-23796
SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets Open Access
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Maria Vähätupa; Janika Nättinen; Antti Jylhä; Ulla Aapola; Marko Kataja; Peeter Kööbi; Tero A. H. Järvinen; Hannu Uusitalo; Hannele Uusitalo-Järvinen
Tags: angiogenesis, hypoxia, oxygen, proteins, proteomics
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3294-3306. doi:https://doi.org/10.1167/iovs.18-23831
Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks Open Access
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Maurizio Battaglia Parodi; Alessandro Arrigo; Francesco Romano; Emanuela Aragona; Alessandro Marchese; Maria Vittoria Cicinelli; Stefano Mercuri; Francesco Bandello
Tags: angioid streaks, choroidal neovascularization, heart failure
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3314-3319. doi:https://doi.org/10.1167/iovs.18-24291
Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice Open Access
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Michael J. Allingham; Nomingerel Tserentsoodol; Peter Saloupis; Priyatham S. Mettu; Scott W. Cousins
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3355-3365. doi:https://doi.org/10.1167/iovs.17-23073
Relationship Between Foveal Cone Structure and Visual Acuity Measured With Adaptive Optics Scanning Laser Ophthalmoscopy in Retinal Degeneration Open Access
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Katharina G. Foote; Panagiota Loumou; Shane Griffin; Jia Qin; Kavitha Ratnam; Travis C. Porco; Austin Roorda; Jacque L. Duncan
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3385-3393. doi:https://doi.org/10.1167/iovs.17-23708
Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease Open Access
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Delu Song; Imran Mohammed; Rupak Bhuyan; Takashi Miwa; Allison Lesher Williams; Damodar Gullipalli; Sayaka Sato; Ying Song; Joshua L. Dunaief; Wen-Chao Song
Tags: familial hypercholesterolemia, family history, fludarabine monophosphate, mice, complement system proteins
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3405-3415. doi:https://doi.org/10.1167/iovs.18-24133
Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression Open Access
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Marco Nassisi; Wenying Fan; Yue Shi; Jianqin Lei; Enrico Borrelli; Michael Ip; Srinivas R. Sadda
Tags: age-related macular degeneration, atrophy, choroidal neovascularization, eye, face
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3431-3439. doi:https://doi.org/10.1167/iovs.18-24143
3-Hydroxypyruvate Destabilizes Hypoxia Inducible Factor and Induces Angiostasis Open Access
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Charandeep Singh; Amit Sharma; George Hoppe; Weilin Song; Youstina Bolok; Jonathan E. Sears
Tags: hypoxia, metabolites, pyruvates
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3440-3448. doi:https://doi.org/10.1167/iovs.18-24120
Significant Relationship of Visual Field Sensitivity in Central 10° to Thickness of Retinal Layers in Retinitis Pigmentosa Open Access
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Akira Sayo; Shinji Ueno; Taro Kominami; Satoshi Okado; Daiki Inooka; Shiori Komori; Hiroko Terasaki
Tags: retinitis pigmentosa, visual fields, spectral domain-optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3469-3475. doi:https://doi.org/10.1167/iovs.18-24635
Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation Open Access
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Mayu Moriguchi; Shinsuke Nakamura; Yuki Inoue; Anri Nishinaka; Maho Nakamura; Masamitsu Shimazawa; Hideaki Hara
Tags: injections, iodates, macrophages, mice, photoreceptors
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3476-3487. doi:https://doi.org/10.1167/iovs.17-23532
Increased Inner Retinal Layer Reflectivity in Eyes With Acute CRVO Correlates With Worse Visual Outcomes at 12 Months Open Access
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Nitish Mehta; Fabio Lavinsky; Sarra Gattoussi; Michael Seiler; Kenneth J. Wald; Hiroshi Ishikawa; Gadi Wollstein; Joel Schuman; K. Bailey Freund; Rishi Singh; Yasha Modi
Tags: eye, visual acuity, vision, cohort studies
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3503-3510. doi:https://doi.org/10.1167/iovs.18-24153
Genipin-Crosslinked Donor Sclera for Posterior Scleral Contraction/Reinforcement to Fight Progressive Myopia Open Access
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Anquan Xue; Linyan Zheng; Guilin Tan; Shaoqun Wu; Yue Wu; Lingyun Cheng; Jia Qu
Tags: donors, eye, myopia, reinforcement, sclera
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3564-3573. doi:https://doi.org/10.1167/iovs.17-23707
Surgical Removal of Internal Limiting Membrane and Layering of AAV Vector on the Retina Under Air Enhances Gene Transfection in a Nonhuman Primate Open Access
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Kelvin Yi Chong Teo; Shu Yen Lee; Amutha Veluchamy Barathi; Sai Bo Bo Tun; Licia Tan; Ian Jeffery Constable
Tags: diagnostic imaging, excision, eye, genes, primates
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3574-3583. doi:https://doi.org/10.1167/iovs.18-24333
Retinopathy of Prematurity Trends in Taiwan: A 10-Year Nationwide Population Study Open Access
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Eugene Yu-Chuan Kang; Reyin Lien; Nan-Kai Wang; Chi-Chun Lai; Kuan-Jen Chen; Yih-Shiou Hwang; Ciao-Ming Lin; Wei-Chi Wu; Kuang-Hung Hsu
Tags: epidemiology, incidence, infant, premature, population studies, retinopathy of prematurity
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3599-3607. doi:https://doi.org/10.1167/iovs.18-24020
Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage Open Access
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Nasir Mat Nor; Cindy X. Guo; Ilva D. Rupenthal; Ying-Shan Chen; Colin R. Green; Monica L. Acosta
Tags: connexin 43, electroretinography, peptides, photodamaged skin, choroid
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3682-3693. doi:https://doi.org/10.1167/iovs.17-22829
Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment Open Access
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Lee Kiang; Bing X. Ross; Jingyu Yao; Sumathi Shanmugam; Chris A. Andrews; Sean Hansen; Cagri G. Besirli; David N. Zacks; Steven F. Abcouwer
Tags: cytokine, inflammatory response, mice, microglia, retinal detachment
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3767-3778. doi:https://doi.org/10.1167/iovs.18-24489

Retinal Cell Biology

Defined Conditions for Differentiation of Functional Retinal Ganglion Cells From Human Pluripotent Stem Cells Open Access
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Junwon Lee; Sang-Hwi Choi; Young-Beom Kim; Ikhyun Jun; Jin Jea Sung; Dongjin R. Lee; Yang In Kim; Myung Soo Cho; Suk Ho Byeon; Dae-Sung Kim; Dong-Wook Kim
Tags: eye, pluripotent stem cells, prescriptions, drug, retinal ganglion cells, pax6 transcription factor
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3531-3542. doi:https://doi.org/10.1167/iovs.17-23439
Capn5 Expression in the Healthy and Regenerating Zebrafish Retina Open Access
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Cagney E. Coomer; Ann C. Morris
Tags: photoreceptors, retina, tissue degeneration, zebrafish, retinal cone
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3643-3654. doi:https://doi.org/10.1167/iovs.18-24278
Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization Open Access
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Juha Song; Kihwang Lee; Sung Wook Park; Hyewon Chung; Daun Jung; Yi Rang Na; Hailian Quan; Chang Sik Cho; Jeong-Hwan Che; Jeong Hun Kim; Jae-Hak Park; Seung Hyeok Seok
Tags: choroidal neovascularization, lactic acid, macrophages, vascular endothelial growth factor a, mice
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3747-3754. doi:https://doi.org/10.1167/iovs.18-23892

Visual Neuroscience

Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia Open Access
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Edward H. Silson; Tomas S. Aleman; Aimee Willett; Leona W. Serrano; Denise J. Pearson; Andreas M. Rauschecker; Albert M. Maguire; Chris I. Baker; Jean Bennett; Manzar Ashtari
Tags: prolactin-releasing hormone, visual fields, choroideremia, perimetry
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3249-3258. doi:https://doi.org/10.1167/iovs.18-23929

Review

Ocular Biomarkers of Alzheimer's Disease: The Role of Anterior Eye and Potential Future Directions Open Access
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Cirous Dehghani; Shaun Frost; Rajiv Jayasena; Colin L. Masters; Yogesan Kanagasingam
Tags: alzheimer's disease, biological markers, cornea, eye, lens, crystalline
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 3554-3563. doi:https://doi.org/10.1167/iovs.18-24694
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