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Anatomy and Pathology/Oncology

The Impact of Choroidal Swelling on Optic Nerve Head Deformation Open Access
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Andrew J. Feola; Emily S. Nelson; Jerry Myers; C. Ross Ethier; Brian C. Samuels
Tags: body tissue, choroid, edema, optic disk
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4172-4181. doi:https://doi.org/10.1167/iovs.18-24463
Wide-Field In Vivo Confocal Microscopy of Meibomian Gland Acini and Rete Ridges in the Eyelid Margin Open Access
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Scott Zhou; Danielle M. Robertson
Tags: diagnostic imaging, eyelid margin, meibomian gland, microscopy, confocal, eyelid
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4249-4257. doi:https://doi.org/10.1167/iovs.18-24497

Biochemistry and Molecular Biology

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4) Open Access
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T. J. Hollingsworth; Marko Z. Radic; Sarka Beranova-Giorgianni; Francesco Giorgianni; Yanming Wang; Alessandro Iannaccone
Tags: arginine, citrullination, mice, western blotting, retina
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3808-3815. doi:https://doi.org/10.1167/iovs.18-24118
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway Open Access
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Na Wang; Chen Zou; Shuzhi Zhao; Yunzhi Wang; Changjing Han; Zhi Zheng
Tags: angptl3 gene, diabetic retinopathy, fenofibrate, inflammation, apoptosis
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4210-4217. doi:https://doi.org/10.1167/iovs.18-24155
Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis Open Access
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Nethrajeith Srinivasalu; Chanyi Lu; Miaozhen Pan; Peter Sol Reinach; Yingying Wen; Yang Hu; Jia Qu; Xiangtian Zhou
Tags: caviidae, cyclic amp, eye, gene expression, genes
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4318-4325. doi:https://doi.org/10.1167/iovs.17-224685

Clinical and Epidemiologic Research

The EYE-MI Pilot Study: A Prospective Acute Coronary Syndrome Cohort Evaluated With Retinal Optical Coherence Tomography Angiography Open Access
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Louis Arnould; Charles Guenancia; Arthur Azemar; Guillaume Alan; Stéphane Pitois; Florence Bichat; Marianne Zeller; Pierre-Henry Gabrielle; Alain M. Bron; Catherine Creuzot-Garcher; Yves Cottin
Tags: acute coronary syndromes, angiogram, cohort studies, eye, heart disease risk factors
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4299-4306. doi:https://doi.org/10.1167/iovs.18-24090

Cornea

Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients Open Access
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Gabriela Mahelková; Marie Česká Burdová; Šárka Malá; Lucie Hoskovcová; Dagmar Dotřelová; Kateřina Štechová
Tags: cornea, insulin, nerve fibers
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3800-3807. doi:https://doi.org/10.1167/iovs.18-24265
A Novel Murine Model of Radiation Keratopathy Open Access
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Deshea L. Harris; Takefumi Yamaguchi; Pedram Hamrah
Tags: cornea, mice, radiation, neurons, cd45 antigens
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3889-3896. doi:https://doi.org/10.1167/iovs.18-24567
Resolvin E1 Inhibits Corneal Allograft Rejection in High-Risk Corneal Transplantation Open Access
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Han Wang; Qingqing Zhao; Dan Luo; Yizhou Yin; Ting Li; Min Zhao
Tags: cornea, keratoplasty, tissue transplants, transplant rejection, rejection (psychology)
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3911-3919. doi:https://doi.org/10.1167/iovs.18-24562
Comparison of Standard Versus Accelerated Corneal Collagen Cross-Linking for Keratoconus: A Meta-Analysis Open Access
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Daizong Wen; Qi Li; Benhao Song; Ruixue Tu; Qinmei Wang; David P. S. O'Brart; Colm McAlinden; Jinhai Huang
Tags: corneal collagen cross-linking, keratoconus, meta-analysis, keratometry, visual acuity
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3920-3931. doi:https://doi.org/10.1167/iovs.18-24656
Hemin Promotes Corneal Allograft Survival Through the Suppression of Macrophage Recruitment and Activation Open Access
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Ye Dai; Xiaokang Cheng; Jianfeng Yu; Xiaoqing Chen; Yichen Xiao; Fen Tang; Yingqi Li; Shangtao Wan; Wenru Su; Dan Liang
Tags: allografting, cornea, hemin, macrophages, transplant rejection
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3952-3962. doi:https://doi.org/10.1167/iovs.17-23327
Ambient Air Currents Activate Corneal Nerves During Ocular Desiccation in Rats: Simultaneous Recordings of Neural Activity and Corneal Temperature Open Access
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Harumitsu Hirata; Valentina Dallacasagrande; Kamila Mizerska; Evguenia Ivakhnitskaia; Mark I. Rosenblatt
Tags: body temperature, cornea, desiccation, neurons, temperature
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4031-4043. doi:https://doi.org/10.1167/iovs.18-24604
Instability of TCF4 Triplet Repeat Expansion With Parent–Child Transmission in Fuchs' Endothelial Corneal Dystrophy Open Access
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Joanna S. Saade; Chao Xing; Xin Gong; Zhengyang Zhou; V. Vinod Mootha
Tags: alleles, child, endothelium, hereditary corneal dystrophy, parent
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4065-4070. doi:https://doi.org/10.1167/iovs.18-24119
Differential Distribution of Laminin N-Terminus α31 Across the Ocular Surface: Implications for Corneal Wound Repair Open Access
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Valentina Barrera; Lee D. Troughton; Valentina Iorio; Siyin Liu; Olutobi Oyewole; Carl M. Sheridan; Kevin J. Hamill
Tags: antibodies, cornea, epithelium, laminin, wound healing
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4082-4093. doi:https://doi.org/10.1167/iovs.18-24037
Factors Affecting Microvascular Responses in the Bulbar Conjunctiva in Habitual Contact Lens Wearers Open Access
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Liang Hu; Ce Shi; Hong Jiang; Yingying Shi; Zubin Sethi; Jianhua Wang
Tags: conjunctiva, contact lenses, hairy-cell leukemia, hydrochloric acid, microvascular network
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4108-4114. doi:https://doi.org/10.1167/iovs.18-24216
Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation Open Access
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Makiko Nakahara; Naoki Okumura; Shinichiro Nakano; Noriko Koizumi
Tags: cornea, corneal endothelium, mitogen-activated protein kinase p38, mitogen-activated protein kinase inhibitors, endothelial cells
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4218-4227. doi:https://doi.org/10.1167/iovs.18-24394
TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway Open Access
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Xinhan Cui; Nan Gao; Rao Me; Jianjiang Xu; Fu-Shin X. Yu
Tags: cornea, thymic stromal lymphopoietin, mice, dendritic cells, keratitis
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4228-4237. doi:https://doi.org/10.1167/iovs.18-24672
Ophthalmic Nonsteroidal Anti-Inflammatory Drugs as a Therapy for Corneal Dystrophies Caused by SLC4A11 Mutation Open Access
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Kumari Alka; Joseph R. Casey
Tags: anti-inflammatory agents, non-steroidal, diclofenac, eye, hereditary corneal dystrophy, mutation
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4258-4267. doi:https://doi.org/10.1167/iovs.18-24301

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Eye Tracking Results in Postconcussive Syndrome Versus Normative Participants Open Access
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Paul A. Wetzel; Anne S. Lindblad; Hardik Raizada; Nathan James; Caroline Mulatya; Mary A. Kannan; Zoe Villamar; George T. Gitchel; Lindell K. Weaver
Tags: brain concussion, eye-tracking, post-concussion syndrome, traumatic brain injury, mild, eye
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4011-4019. doi:https://doi.org/10.1167/iovs.18-23815
Retinal Microvascular Impairment in the Early Stages of Parkinson's Disease Open Access
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William Robert Kwapong; Hua Ye; Chenlei Peng; Xiran Zhuang; Jianhua Wang; Meixiao Shen; Fan Lu
Tags: blood capillaries, impairment, parkinson disease, microvascular network, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4115-4122. doi:https://doi.org/10.1167/iovs.17-23230
Amblyopic Suppression: Passive Attenuation, Enhanced Dichoptic Masking by the Fellow Eye or Reduced Dichoptic Masking by the Amblyopic Eye? Open Access
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Jiawei Zhou; Alexandre Reynaud; Zhimo Yao; Rong Liu; Lixia Feng; Yifeng Zhou; Robert F. Hess
Tags: amblyopia, attenuation, eye, perceptual masking, spatial frequency
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4190-4197. doi:https://doi.org/10.1167/iovs.18-24206

Genetics

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect Open Access
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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
Tags: cohort studies, disease susceptibility, esotropia, genetics, genome-wide association study
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4054-4064. doi:https://doi.org/10.1167/iovs.18-24082

Glaucoma

Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images Open Access
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Xiangyun J. Duan; Joan L. Jefferys; Harry A. Quigley
Tags: eye, optic disk, optical coherence tomography, glaucoma, surrogate endpoints
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3816-3826. doi:https://doi.org/10.1167/iovs.18-24469
Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous Visual Field Defect in Open-Angle Glaucoma Open Access
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Jong Chul Han; Jae Hwan Choi; Do Young Park; Eun Jung Lee; Changwon Kee
Tags: glaucomatous visual field defect, language morphology, morphology, open-angle glaucoma, optic disk
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3842-3851. doi:https://doi.org/10.1167/iovs.18-24588
Resveratrol Delays Retinal Ganglion Cell Loss and Attenuates Gliosis-Related Inflammation From Ischemia-Reperfusion Injury Open Access
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Hongdou Luo; Jiejie Zhuang; Piaopiao Hu; Wei Ye; Shanshan Chen; Yulian Pang; Ningfeng Li; Cong Deng; Xu Zhang
Tags: gliosis, inflammation, reperfusion injury, resveratrol, wounds and injuries
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3879-3888. doi:https://doi.org/10.1167/iovs.18-23806
Matricellular Protein Levels in Aqueous Humor and Surgical Outcomes of Trabeculectomy Open Access
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Zhihua Zhang; Yuyu Miao; Jing Wang; Minwen Zhou; Mingshui Fu; Ying Wang
Tags: aqueous humor, proteins, surgical outcome, trabeculectomy, sparc study
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3906-3910. doi:https://doi.org/10.1167/iovs.18-24534
Ultrastructural Morphology of the Optic Nerve Head in Aged and Glaucomatous Mice Open Access
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Ying Zhu; Anthony C. Pappas; Rui Wang; Philip Seifert; Daniel Sun; Tatjana C. Jakobs
Tags: axon, glaucoma, mice, neurons, optic disk
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3984-3996. doi:https://doi.org/10.1167/iovs.18-23885
Modeling the Origin of the Ocular Pulse and Its Impact on the Optic Nerve Head Open Access
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Yuejiao Jin; Xiaofei Wang; Liang Zhang; Jost B. Jonas; Tin Aung; Leopold Schmetterer; Michaël J. A. Girard
Tags: diastole, intraocular pressure, optic disk, systole, pulse volume
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3997-4010. doi:https://doi.org/10.1167/iovs.17-23454
Change of β-Zone Parapapillary Atrophy During Axial Elongation: Boramae Myopia Cohort Study Report 3 Open Access
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Kyoung Min Lee; Ho-Kyung Choung; Martha Kim; Sohee Oh; Seok Hwan Kim
Tags: atrophy, cohort studies, eye, myopia, optic disk
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4020-4030. doi:https://doi.org/10.1167/iovs.18-24775
Increased Iris Stiffness in Patients With a History of Angle-Closure Glaucoma: An Image-Based Inverse Modeling Analysis Open Access
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Anup Dev Pant; Priyanka Gogte; Vanita Pathak-Ray; Syril K. Dorairaj; Rouzbeh Amini
Tags: angle closure glaucoma, immune reconstitution inflammatory syndrome, iris, medical history
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4134-4142. doi:https://doi.org/10.1167/iovs.18-24327
An Optical Coherence Tomography Angiography Study of the Relationship Between Foveal Avascular Zone Size and Retinal Vessel Density Open Access
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Junki Kwon; Jaewan Choi; Joong Won Shin; Jiyun Lee; Michael S. Kook
Tags: angiogram, eye, glaucoma, optical coherence tomography, respiratory care units
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4143-4153. doi:https://doi.org/10.1167/iovs.18-24168

Immunology and Microbiology

Global Variations and Challenges With Tubercular Uveitis in the Collaborative Ocular Tuberculosis Study Open Access
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Rupesh Agrawal; Dinesh Visva Gunasekeran; Dhananjay Raje; Aniruddha Agarwal; Quan Dong Nguyen; Onn Min Kon; Carlos Pavesio; Vishali Gupta; for the Collaborative Ocular Tuberculosis Study Group
Tags: eye, ocular tuberculosis, ophthalmology, tuberculous uveitis, tuberculosis
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4162-4171. doi:https://doi.org/10.1167/iovs.18-24102
Detection of Complement Activators in Immune Attack Eyes After iPS-Derived Retinal Pigment Epithelial Cell Transplantation Open Access
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Sunao Sugita; Kenichi Makabe; Shota Fujii; Masayo Takahashi
Tags: complement system proteins, idiopathic pneumonia syndrome, retinal pigment cell, eye, transcriptional activation
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4198-4209. doi:https://doi.org/10.1167/iovs.18-24769
Identification and Visualization of a Distinct Microbiome in Ocular Surface Conjunctival Tissue Open Access
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Jerome Ozkan; Minas Coroneo; Mark Willcox; Bernd Wemheuer; Torsten Thomas
Tags: body tissue, conjunctiva, fornix (brain), microbiome, community
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4268-4276. doi:https://doi.org/10.1167/iovs.18-24651

Low Vision

Fonts Designed for Macular Degeneration: Impact on Reading Open Access
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Ying-Zi Xiong; Ethan A. Lorsung; John Stephen Mansfield; Charles Bigelow; Gordon E. Legge
Tags: macular degeneration, reading (activity), prescriptions, drug
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4182-4189. doi:https://doi.org/10.1167/iovs.18-24334

Multidisciplinary Ophthalmic Imaging

Oxygen-Induced Retinopathy and Choroidopathy: In Vivo Longitudinal Observation of Vascular Changes Using OCTA Open Access
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Yongjoo Kim; Hye Kyoung Hong; Jang Ryul Park; WooJhon Choi; Se Joon Woo; Kyu Hyung Park; Wang-Yuhl Oh
Tags: choroid diseases, diagnostic imaging, eye, oxygen, retinal diseases
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3932-3942. doi:https://doi.org/10.1167/iovs.18-24320

Retina

Rhythmic Regulation of Photoreceptor and RPE Genes Important for Vision and Genetically Associated With Severe Retinal Diseases Open Access
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Patrick Vancura; Erika Csicsely; Annalisa Leiser; P. Michael Iuvone; Rainer Spessert
Tags: genes, photoreceptors, regulation, retina, retinal diseases
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3789-3799. doi:https://doi.org/10.1167/iovs.18-24558
Central Retina Functional Damage in Usher Syndrome Type 2: 22 Years of Focal Macular ERG Analysis in a Patient Population From Central and Southern Italy Open Access
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Lucia Galli-Resta; Giorgio Placidi; Francesca Campagna; Lucia Ziccardi; Marco Piccardi; Angelo Minnella; Edoardo Abed; Silvia Iovine; Paolo Maltese; Matteo Bertelli; Benedetto Falsini
Tags: electroretinography, italy, retina, retinal cone, syndrome
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3827-3835. doi:https://doi.org/10.1167/iovs.17-23703
Choroidal Structural Changes Correlate With Neovascular Activity in Neovascular Age Related Macular Degeneration Open Access
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Alessandro Invernizzi; Eleonora Benatti; Mariano Cozzi; Stefano Erba; Shiva Vaishnavi; Kiran Kumar Vupparaboina; Giovanni Staurenghi; Jay Chhablani; Mark Gillies; Francesco Viola
Tags: age-related macular degeneration, choroid, choroidal neovascularization, cortical blindness, eye
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3836-3841. doi:https://doi.org/10.1167/iovs.18-23960
Increased Axial Length Corresponds to Decreased Retinal Light Dose: A Parsimonious Explanation for Decreasing AMD Risk in Myopia Open Access
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Michael G. Quigley; Ian Powell; Walter Wittich
Tags: eye, light exposure, myopia, pupil, magnification
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3852-3857. doi:https://doi.org/10.1167/iovs.17-23696
Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography Open Access
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Peter L. Nesper; Amani A. Fawzi
Tags: angiogram, blood capillaries, optical coherence tomography, parafoveal region, venule
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3858-3867. doi:https://doi.org/10.1167/iovs.18-24710
Choroidal Vascular Reactivity in Central Serous Chorioretinopathy Open Access
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Felice Cardillo Piccolino; Marco Lupidi; Carlo Cagini; Daniela Fruttini; Massimo Nicolò; Chiara Maria Eandi; Silvia Tito
Tags: angiogram, central serous chorioretinopathy, chief complaint, diagnostic imaging, doppler hemodynamics
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3897-3905. doi:https://doi.org/10.1167/iovs.18-23995
Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging Open Access
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Ignacio Melgar-Asensio; Irawati Kandela; Fraser Aird; Soesiawati R. Darjatmoko; Cristobal de los Rios; Christine M. Sorenson; Daniel M. Albert; Nader Sheibani; Jack Henkin
Tags: diagnostic imaging, drug clearance, eye, oryctolagus cuniculus, peptides
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4071-4081. doi:https://doi.org/10.1167/iovs.18-24087
The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene Open Access
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Mays Talib; Mary J. van Schooneveld; Caroline Van Cauwenbergh; Jan Wijnholds; Jacoline B. ten Brink; Ralph J. Florijn; Nicoline E. Schalij-Delfos; Gislin Dagnelie; Maria M. van Genderen; Elfride De Baere; Magda A. Meester-Smoor; Julie De Zaeytijd; Frans P. M. Cremers; L. Ingeborgh van den Born; Alberta A. Thiadens; Carel B. Hoyng; Caroline C. Klaver; Bart P. Leroy; Arthur A. Bergen; Camiel J. F. Boon
Tags: genes, heterozygote, phenotype, signs and symptoms
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4123-4133. doi:https://doi.org/10.1167/iovs.17-23453
Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration Open Access
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Rose Tan; Robyn H. Guymer; Chi D. Luu
Tags: age-related macular degeneration, digestive tract decontamination, eye, pathophysiology, rod photoreceptors
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4154-4161. doi:https://doi.org/10.1167/iovs.18-23970
Residual Cone Structure in Patients With X-Linked Cone Opsin Mutations Open Access
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Emily J. Patterson; Angelos Kalitzeos; Melissa Kasilian; Jessica C. Gardner; Jay Neitz; Alison J. Hardcastle; Maureen Neitz; Joseph Carroll; Michel Michaelides
Tags: mutation, opsin, retinal cone, x-linked inheritance
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4238-4248. doi:https://doi.org/10.1167/iovs.18-24699
Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy Open Access
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Luke Nicholson; Roxanne Crosby-Nwaobi; Joana C. Vasconcelos; A. Toby Prevost; Jayashree Ramu; Amy Riddell; James W. Bainbridge; Philip G. Hykin; Sobha Sivaprasad
Tags: aflibercept, panretinal photocoagulation, proliferative diabetic retinopathy, eye, oximetry
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4277-4284. doi:https://doi.org/10.1167/iovs.17-23509
Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography Open Access
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Rachel Patel; Jie Wang; J. Peter Campbell; Lee Kiang; Andreas Lauer; Christina Flaxel; Thomas Hwang; Brandon Lujan; David Huang; Steven T. Bailey; Yali Jia
Tags: choroidal neovascularization, angiogram, optical coherence tomography
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4285-4291. doi:https://doi.org/10.1167/iovs.18-24624
Statistical Model of Optical Coherence Tomography Angiography Parameters That Correlate With Severity of Diabetic Retinopathy Open Access
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Mohammed Ashraf; Peter L. Nesper; Lee M. Jampol; Fei Yu; Amani A. Fawzi
Tags: angiogram, diabetic retinopathy, eye, models, statistical, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4292-4298. doi:https://doi.org/10.1167/iovs.18-24142
Anti-VEGF Monotherapy Versus Photodynamic Therapy and Anti-VEGF Combination Treatment for Neovascular Age-Related Macular Degeneration: A Meta-Analysis Open Access
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Yang Gao; Tao Yu; Yue Zhang; Guangfu Dang
Tags: anti-vascular endothelial growth factor therapy, combined modality therapy, exudative age-related macular degeneration, meta-analysis, photochemotherapy
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4307-4317. doi:https://doi.org/10.1167/iovs.17-23747

Retinal Cell Biology

Temporal Requirement of Mab21l2 During Eye Development in Chick Reveals Stage-Dependent Functions for Retinogenesis Open Access
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Soufien Sghari; Lena Gunhaga
Tags: embryo, eye development, retina, optic vesicle, down-regulation
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3869-3878. doi:https://doi.org/10.1167/iovs.18-24236
Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina Open Access
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Kota Sato; Yukihiro Shiga; Yurika Nakagawa; Kosuke Fujita; Koji M. Nishiguchi; Hiroshi Tawarayama; Namie Murayama; Shigeto Maekawa; Takeshi Yabana; Kazuko Omodaka; Shota Katayama; Qiwei Feng; Satoru Tsuda; Toru Nakazawa
Tags: mice, optic nerve, retina, optic nerve injuries
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3943-3951. doi:https://doi.org/10.1167/iovs.18-23784
MicroRNA-124 Dysregulation Is Associated With Retinal Inflammation and Photoreceptor Death in the Degenerating Retina Open Access
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Joshua A. Chu-Tan; Matt Rutar; Kartik Saxena; Riemke Aggio-Bruce; Rohan W. Essex; Krisztina Valter; Haihan Jiao; Nilisha Fernando; Yvette Wooff; Michele C. Madigan; Jan Provis; Riccardo Natoli
Tags: micrornas, monocyte chemoattractant protein-1, photoreceptors, retina, retinal degeneration
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4094-4105. doi:https://doi.org/10.1167/iovs.18-24623

Visual Psychophysics and Physiological Optics

Symbol Discrimination Speed in Children With Visual Impairments Open Access
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Annemiek D. Barsingerhorn; F. Nienke Boonstra; Jeroen Goossens
Tags: child, cortical blindness, reaction time, symbols, visual impairment
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3963-3972. doi:https://doi.org/10.1167/iovs.17-23167
Development of Symbol Discrimination Speed in Children With Normal Vision Open Access
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Annemiek D. Barsingerhorn; F. Nienke Boonstra; Jeroen Goossens
Tags: child, emmetropia, reaction time, symbols, visual processing
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3973-3983. doi:https://doi.org/10.1167/iovs.17-23168

Review

The Corneal Basement Membranes and Stromal Fibrosis Open Access
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Carla S. Medeiros; Gustavo K. Marino; Marcony R. Santhiago; Steven E. Wilson
Tags: cornea, fibrosis, evidence-based medicine
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4044-4053. doi:https://doi.org/10.1167/iovs.18-24428

Letters to the Editor

Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics Open Access
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Eric Wakshull; Robert Avery; Mauricio Maia
Tags: anti-vascular endothelial growth factor therapy, therapeutics, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4106. doi:https://doi.org/10.1167/iovs.18-24792
Author Response: Comments on Assays Used to Measure VEGF in the Presence of Anti-VEGF Therapeutics Open Access
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Hidenori Takahashi; Yasuo Yanagi
Tags: anti-vascular endothelial growth factor therapy, therapeutics, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4107. doi:https://doi.org/10.1167/iovs.18-25216

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science August 2018, Vol.59, 3868. doi:https://doi.org/10.1167/iovs.17-23297a
Erratum Open Access
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Investigative Ophthalmology & Visual Science August 2018, Vol.59, 4326. doi:https://doi.org/10.1167/iovs.18-23873a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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