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Editorial

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members – EBAA Commentary Open Access
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Kevin P. Corcoran
Tags: body tissue, eye, surveys
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4793-4795. doi:https://doi.org/10.1167/iovs.18-25631
A New Online Portal Will Match Eye Banks With Researchers Seeking Human Ocular Tissues Open Access
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Christine A. Curcio
Tags: body tissue, eye banks, research personnel
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4796-4797. doi:https://doi.org/10.1167/iovs.18-25632

Research Highlight

Visualizing Neuronal Adaptation Over Time After Treatment of Strabismus Open Access
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Jérome Fleuriet; Linda K. McLoon
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5022-5024. doi:https://doi.org/10.1167/iovs.18-25651

Anatomy and Pathology/Oncology

The Cytoskeleton in the Extraocular Muscles of Desmin Knockout Mice Open Access
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Maria Angels Rodríguez; Jing-Xia Liu; Kimmo Parkkonen; Zhenlin Li; Fatima Pedrosa Domellöf
Tags: cytoskeleton, desmin, muscle of orbit, mice, knockout, muscle fibers
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4847-4855. doi:https://doi.org/10.1167/iovs.18-24508
Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors Open Access
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Yong Jie Qin; Wai Kit Chu; Li Huang; Clara Hoi Yen Ng; Tommy Chung Yan Chan; Di Cao; Cheng Yang; Liang Zhang; Shao Ping Huang; Juan Li; Hong Liang Lin; Wen Qian Li; Li Chen; Andrew V. Schally; Sun On Chan; Hong Yang Zhang; Chi Pui Pang
Tags: antagonists, apoptosis, growth hormone-releasing factor, pectoral compartment nerve block type 1, picture exchange communication system
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5060-5066. doi:https://doi.org/10.1167/iovs.18-24751

Biochemistry and Molecular Biology

Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception Open Access
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Deborah M. Hegarty; Larry L. David; Sue A. Aicher
Tags: cornea, denervation, eye, lacrimal gland, proteins
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5217-5224. doi:https://doi.org/10.1167/iovs.18-25267

Clinical and Epidemiologic Research

Dim Light Exposure and Myopia in Children Open Access
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Erica G. Landis; Victoria Yang; Dillon M. Brown; Machelle T. Pardue; Scott A. Read
Tags: child, light exposure, myopia
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4804-4811. doi:https://doi.org/10.1167/iovs.18-24415
Distribution and Severity of Myopic Maculopathy Among Highly Myopic Eyes Open Access
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Ou Xiao; Xinxing Guo; Decai Wang; Monica Jong; Pei Ying Lee; Linxing Chen; Ian G. Morgan; Padmaja Sankaridurg; Mingguang He
Tags: eye, macular disorders
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4880-4885. doi:https://doi.org/10.1167/iovs.18-24471
Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study Open Access
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Chan-Wei Nien; Chia-Yi Lee; Shih-Chun Chao; Hung-Jui Hsu; Jing-Yang Huang; Chao-Bin Yeh; Hung-Chi Chen; Chi-Chin Sun; Hung-Yu Lin; Shun-Fa Yang
Tags: cohort studies, uveitis
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5053-5059. doi:https://doi.org/10.1167/iovs.18-25039
Prevalence of and Risk Factors for Diabetic Retinopathy in a Rural Chinese Population: The Yangxi Eye Study Open Access
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Guangming Jin; Wei Xiao; Xiaohu Ding; Xiao Xu; Lei An; Nathan Congdon; Jialiang Zhao; Mingguang He
Tags: china, chinese (other dialects), chinese people, diabetic retinopathy, eye
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5067-5073. doi:https://doi.org/10.1167/iovs.18-24280

Cornea

Rose Bengal and Green Light Versus Riboflavin–UVA Cross-Linking: Corneal Wound Repair Response Open Access
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Elvira Lorenzo-Martín; Patricia Gallego-Muñoz; Lucía Ibares-Frías; Susana Marcos; Pablo Pérez-Merino; Itziar Fernández; Irene E. Kochevar; M. Carmen Martínez-García
Tags: cornea, cross-linking, riboflavin, rose bengal, wound healing
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4821-4830. doi:https://doi.org/10.1167/iovs.18-24881
Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts Open Access
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Koji Sugioka; Aya Kodama-Takahshi; Tomoko Sato; Kiyotaka Okada; Junko Murakami; Ah-Mee Park; Hiroshi Mishima; Yoshikazu Shimomura; Shunji Kusaka; Teruo Nishida
Tags: catabolism, collagen, cornea, fibroblasts, gel
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5098-5107. doi:https://doi.org/10.1167/iovs.18-24925
Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model Open Access
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Jin Hyoung Park; Seong-Ho Moon; Dong Hyun Kang; Hyun Jun Um; Soon-Suk Kang; Jae Yong Kim; Hungwon Tchah
Tags: apoptosis, conditioning (psychology), cornea, corneal epithelial cells, dry eye syndromes
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5108-5115. doi:https://doi.org/10.1167/iovs.17-22925
Spontaneous Eye Blink Patterns in Dry Eye: Clinical Correlations Open Access
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Yuandong Su; Qingfeng Liang; Guanyu Su; Ningli Wang; Christophe Baudouin; Antoine Labbé
Tags: dry eye syndromes, eye, blinking
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5149-5156. doi:https://doi.org/10.1167/iovs.18-24690
Effect of Human Corneal Mesenchymal Stromal Cell-derived Exosomes on Corneal Epithelial Wound Healing Open Access
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Ravand Samaeekia; Behnam Rabiee; Ilham Putra; Xiang Shen; Young Jae Park; Peiman Hematti; Medi Eslani; Ali R. Djalilian
Tags: cornea, exosomes, wound healing, epithelium
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5194-5200. doi:https://doi.org/10.1167/iovs.18-24803
Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery Open Access
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Haiou Wang; Jingwei Zheng; Qinxiang Zheng; Fan Yang; Cong Ye; David Meng-da Woo; Vishal Jhanji; Wei Chen
Tags: cataract surgery, incidence, risk factors, eye, surgical procedures, operative
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5210-5216. doi:https://doi.org/10.1167/iovs.18-24750
Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival Open Access
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Tristan Reuer; Ann-Charlott Schneider; Bertan Cakir; Anima D. Bühler; Johanna M. Walz; Thabo Lapp; Clemens Lange; Hansjürgen Agostini; Günther Schlunck; Claus Cursiefen; Thomas Reinhard; Felix Bock; Andreas Stahl
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5277-5284. doi:https://doi.org/10.1167/iovs.18-24287

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

A Novel Dichoptic Optokinetic Nystagmus Paradigm to Quantify Interocular Suppression in Monocular Amblyopia Open Access
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Wen Wen; Sujia Wu; Shu Wang; Leilei Zou; Yan Liu; Rui Liu; Peng Zhang; Sheng He; Hong Liu
Tags: amblyopia, eye, nystagmus, optokinetic
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4775-4782. doi:https://doi.org/10.1167/iovs.17-23661
Neural Plasticity Following Surgical Correction of Strabismus in Monkeys Open Access
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Mythri Pullela; Mehmet N. Ağaoğlu; Anand C. Joshi; Sevda Agaoglu; David K. Coats; Vallabh E. Das
Tags: cercopithecidae, eye, muscle, strabismus, surgical procedures, operative
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5011-5021. doi:https://doi.org/10.1167/iovs.18-25245
Retinal and Cerebral Microvasculopathy: Relationships and Their Genetic Contributions Open Access
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Jacoba A. van de Kreeke; H. Ton Nguyen; Elles Konijnenberg; Jori Tomassen; Anouk den Braber; Mara ten Kate; Carole H. Sudre; Frederik Barkhof; Dorret I. Boomsma; H. Stevie Tan; Frank D. Verbraak; Pieter Jelle Visser
Tags: brain, genetics, heart disease risk factors, twins, white matter
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5025-5031. doi:https://doi.org/10.1167/iovs.18-25341
Loss of CXCR4/CXCL12 Signaling Causes Oculomotor Nerve Misrouting and Development of Motor Trigeminal to Oculomotor Synkinesis Open Access
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Mary C. Whitman; Elaine H. Nguyen; Jessica L. Bell; Alan P. Tenney; Alon Gelber; Elizabeth C. Engle
Tags: axon, cxcr4 receptors, signal transduction, stromal cell-derived factor 1, synkinesis
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5201-5209. doi:https://doi.org/10.1167/iovs.18-25190

Genetics

Clinical Features of a Retinopathy Associated With a Dominant Allele of the RGR Gene Open Access
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Rola Ba-Abbad; Monique Leys; Xinjing Wang; Christina Chakarova; Naushin Waseem; Keren J. Carss; F. Lucy Raymond; Kinga M. Bujakowska; Eric A. Pierce; Omar A. Mahroo; Moin D. Mohamed; Graham E. Holder; Marybeth Hummel; Gavin Arno; Andrew R. Webster
Tags: alleles, genes, retinal diseases, signs and symptoms, genetic pedigree
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4812-4820. doi:https://doi.org/10.1167/iovs.18-25061
Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3 Open Access
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Ighovie F. Onojafe; Lucyanne H. Megan; Madeline G. Melch; Joseph O. Aderemi; Ramakrishna P. Alur; Mones S. Abu-Asab; Chi-Chao Chan; Isa M. Bernardini; Jessica S. Albert; Tiziana Cogliati; David R. Adams; Brian P. Brooks
Tags: albinism, oculocutaneous, albinism, oculocutaneous, type iii, mice, nitisinone, tyrosine
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4945-4952. doi:https://doi.org/10.1167/iovs.16-20293
Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele Open Access
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Bo Chang; Bernard FitzMaurice; Jieping Wang; Benjamin E. Low; Michael V. Wiles; Patsy M. Nishina
Tags: alleles, mice, mutation, phenotype, vascular diseases
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5127-5139. doi:https://doi.org/10.1167/iovs.18-25046

Glaucoma

Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep Open Access
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Alexandra Gogola; Ning-Jiun Jan; Kira L. Lathrop; Ian A. Sigal
Tags: cattle, cercopithecidae, collagen, eye, galveston orientation and amnesia test
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4763-4774. doi:https://doi.org/10.1167/iovs.18-25025
Structure–Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide Open Access
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Susannah Waxman; Chao Wang; Yalong Dang; Ying Hong; Hamed Esfandiari; Priyal Shah; Kira L. Lathrop; Ralitsa T. Loewen; Nils A. Loewen
Tags: endothelin-1, ng-nitroarginine methyl ester, nitric oxide, spectral domain-optical coherence tomography, suidae
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4886-4895. doi:https://doi.org/10.1167/iovs.18-24943
Effects of Lentivirus-Mediated C3 Expression on Trabecular Meshwork Cells and Intraocular Pressure Open Access
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Junkai Tan; Ning Fan; Ningli Wang; BingKai Feng; Ming Yang; Guo Liu; Yun Wang; Xianjun Zhu; Paul L. Kaufman; Iok-Hou Pang; Xuyang Liu
Tags: actins, eye, injections, intraocular pressure, lentivirus
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4937-4944. doi:https://doi.org/10.1167/iovs.18-24978
Diagnostic Capability of Three-Dimensional Macular Parameters for Glaucoma Using Optical Coherence Tomography Volume Scans Open Access
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Alice C. Verticchio Vercellin; Firas Jassim; Linda Yi-Chieh Poon; Edem Tsikata; Boy Braaf; Sneha Shah; Geulah Ben-David; Eric Shieh; Ramon Lee; Huseyin Simavli; Christian J. Que; Georgia Papadogeorgou; Rong Guo; Benjamin J. Vakoc; Brett E. Bouma; Johannes F. de Boer; Teresa C. Chen
Tags: glaucoma, spectral domain-optical coherence tomography, volume, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4998-5010. doi:https://doi.org/10.1167/iovs.18-23813
Decreased d-Serine Levels Prevent Retinal Ganglion Cell Apoptosis in a Glaucomatous Animal Model Open Access
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Xuejin Zhang; Rong Zhang; Xujiao Zhou; Jihong Wu
Tags: animal model, glaucoma, serine, apoptosis, d-serine
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5045-5052. doi:https://doi.org/10.1167/iovs.18-24691
Age-Related Changes in Quantitative Strain of Mouse Astrocytic Lamina Cribrosa and Peripapillary Sclera Using Confocal Microscopy in an Explant Model Open Access
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Cathy Nguyen; Dan Midgett; Elizabeth Kimball; Joan Jefferys; Thao D. Nguyen; Julie Schaub; Mary Pease; Harry Quigley
Tags: astrocytes, cribriform plate, eye, mice, sclera
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5157-5166. doi:https://doi.org/10.1167/iovs.18-25111
Retinal Nerve Fiber Layer Thickness in Children: The Gobi Desert Children Eye Study Open Access
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Chun-Yan Wang; Yan-Fei Zheng; Bin Liu; Zi-Wei Meng; Fei Hong; Xiao-xia Wang; Xiao-Juan Wang; Lagan Du; Ian Y. Wang; Dan Zhu; Yong Tao; Qi Sheng You; Jost B. Jonas
Tags: child, eye, retinal nerve fiber layer, refractive errors
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5285-5291. doi:https://doi.org/10.1167/iovs.18-25418

Lens

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery Open Access
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Jian Jiang; Mahbubul H. Shihan; Yan Wang; Melinda K. Duncan
Tags: cataract surgery, inflammation, inflammatory response, lens (device), lens epithelial cell
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4986-4997. doi:https://doi.org/10.1167/iovs.18-25067

Low Vision

Reading Acuity as a Predictor of Low-Vision Reading Performance Open Access
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Ying-Zi Xiong; Aurélie Calabrèse; Allen M. Y. Cheong; Gordon E. Legge
Tags: reading (activity), visual impairment
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4798-4803. doi:https://doi.org/10.1167/iovs.18-24716

Multidisciplinary Ophthalmic Imaging

Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography Open Access
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Minhaj Alam; Devrim Toslak; Jennifer I. Lim; Xincheng Yao
Tags: angiogram, color, nonproliferative diabetic retinopathy, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4953-4962. doi:https://doi.org/10.1167/iovs.18-24831

Physiology and Pharmacology

Defective Choroidal Blood Flow Baroregulation and Retinal Dysfunction and Pathology Following Sympathetic Denervation of Choroid Open Access
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Chunyan Li; Malinda E. C. Fitzgerald; Nobel Del Mar; Corey Haughey; Anton Reiner
Tags: choroid, electroretinography, eye, pathology, pathophysiology
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5032-5044. doi:https://doi.org/10.1167/iovs.18-24954
Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ETA Receptors, Extracellular Calcium Entry, and Rho Kinase Open Access
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Yen-Lin Chen; Yi Ren; Wenjuan Xu; Robert H. Rosa, Jr; Lih Kuo; Travis W. Hein
Tags: calcium, constriction procedure, endothelin-1, phosphotransferases, retinal venule
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5167-5175. doi:https://doi.org/10.1167/iovs.18-25369
Chronic Intermittent Hypoxia Alters Rat Ophthalmic Artery Reactivity Through Oxidative Stress, Endothelin and Endothelium-Derived Hyperpolarizing Pathways Open Access
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Marielle Mentek; Jessica Morand; Marie Baldazza; Gilles Faury; Florent Aptel; Jean Louis Pepin; Diane Godin-Ribuot; Christophe Chiquet
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5256-5265. doi:https://doi.org/10.1167/iovs.18-25151

Retina

How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids? Open Access
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Dirk-Henning Menz; Nicolas Feltgen; Helge Menz; Bernd-Kristof Müller; Thorsten Lechner; Joachim Dresp; Hans Hoerauf
Tags: cytotoxicity, fluorides, fluorocarbons, liquids, patent foramen ovale
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4841-4846. doi:https://doi.org/10.1167/iovs.18-24698
Changes in Stromal and Luminal Areas of the Choroid in Pachychoroid Diseases: Insights Into the Pathophysiology of Pachychoroid Diseases Open Access
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Minsub Lee; Hyungwoo Lee; Hyung Chan Kim; Hyewon Chung
Tags: central serous chorioretinopathy, choroid, pathophysiology, eye
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4896-4908. doi:https://doi.org/10.1167/iovs.18-25018
A Destabilizing Domain Allows for Fast, Noninvasive, Conditional Control of Protein Abundance in the Mouse Eye – Implications for Ocular Gene Therapy Open Access
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Shyamtanu Datta; Marian Renwick; Viet Q. Chau; Fang Zhang; Emily R. Nettesheim; Daniel M. Lipinski; John D. Hulleman
Tags: dihydrofolate reductase, eye, gene therapy, mice, proteins
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4909-4920. doi:https://doi.org/10.1167/iovs.18-24987
Location of Ocular Tessellations in Japanese: Population-Based Kumejima Study Open Access
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Takehiro Yamashita; Aiko Iwase; Yuya Kii; Hiroshi Sakai; Hiroto Terasaki; Taiji Sakamoto; Makoto Araie
Tags: cohort studies, eye, japanese, fundus photography, nose
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4963-4967. doi:https://doi.org/10.1167/iovs.18-25007
The Carnitine Shuttle Pathway is Altered in Patients With Neovascular Age-Related Macular Degeneration Open Access
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Sabrina L. Mitchell; Karan Uppal; Samantha M. Williamson; Ken Liu; L. Goodwin Burgess; ViLinh Tran; Allison C. Umfress; Kelli L. Jarrell; Jessica N. Cooke Bailey; Anita Agarwal; Margaret Pericak-Vance; Jonathan L. Haines; William K. Scott; Dean P. Jones; Milam A. Brantley, Jr
Tags: carnitine, exudative age-related macular degeneration, metabolites, metabolomics, plasma
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4978-4985. doi:https://doi.org/10.1167/iovs.18-25137
Peripapillary Microvascular and Neural Changes in Diabetes Mellitus: An OCT-Angiography Study Open Access
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Stela Vujosevic; Andrea Muraca; Valentina Gatti; Luca Masoero; Marco Brambilla; Barbara Cannillo; Edoardo Villani; Paolo Nucci; Stefano De Cillà
Tags: angiogram, diabetes mellitus, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5074-5081. doi:https://doi.org/10.1167/iovs.18-24891
Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish Open Access
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Jared D. Chrispell; Enheng Dong; Shoji Osawa; Jiandong Liu; D. Joshua Cameron; Ellen R. Weiss
Tags: larva, recovery of function, retinal cone, vision, zebrafish
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5116-5124. doi:https://doi.org/10.1167/iovs.18-24455
Ocular Biometric Diurnal Rhythms in Emmetropic and Myopic Adults Open Access
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Hannah J. Burfield; Nimesh B. Patel; Lisa A. Ostrin
Tags: adult, biometry, choroid, circadian rhythms, refractive errors
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5176-5187. doi:https://doi.org/10.1167/iovs.18-25389
RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function Open Access
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Tomas S. Aleman; Katherine E. Uyhazi; Leona W. Serrano; Vidyullatha Vasireddy; Scott J. Bowman; Michael J. Ammar; Denise J. Pearson; Albert M. Maguire; Jean Bennett
Tags: mutation, retina, retinal degeneration, rod photoreceptors, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5225-5236. doi:https://doi.org/10.1167/iovs.18-24708
Drusen and Age-Related Scattered Hypofluorescent Spots on Late-Phase Indocyanine Green Angiography, a Candidate Correlate of Lipid Accumulation Open Access
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Ling Chen; Xiongze Zhang; Miaoling Li; Yuhong Gan; Feng Wen
Tags: drusen, indocyanine green angiography, lipids
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5237-5245. doi:https://doi.org/10.1167/iovs.18-25124
Variation of Retinal and Choroidal Vasculatures in Patients With Age-Related Macular Degeneration Open Access
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Boram Lee; Jaemoon Ahn; Cheolmin Yun; Seong-woo Kim; Jaeryung Oh
Tags: age-related macular degeneration, eye, retina, choroid, angiogram
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5246-5255. doi:https://doi.org/10.1167/iovs.17-23600
Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection Open Access
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Yu Zhang; Hojjat Bazzazi; Raquel Lima e Silva; Niranjan B. Pandey; Jordan J. Green; Peter A. Campochiaro; Aleksander S. Popel
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5266-5276. doi:https://doi.org/10.1167/iovs.17-23632

Retinal Cell Biology

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy Open Access
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Arul J. Duraisamy; Manish Mishra; Anjaneyulu Kowluru; Renu A. Kowluru
Tags: diabetes mellitus, diabetic retinopathy, dna (cytosine-5-)-methyltransferase 1, epigenetics, glucose
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4831-4840. doi:https://doi.org/10.1167/iovs.18-24548
Altered Decorin Biology in Proliferative Vitreoretinopathy: A Mechanistic and Cohort Study Open Access
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Ghazala Begum; Jenna O'Neill; Rishika Chaudhary; Karen Blachford; David R. J. Snead; Martin Berry; Robert A. H. Scott; Ann Logan; Richard J. Blanch
Tags: cell culture techniques, cohort studies, enzyme-linked immunosorbent assay, epithelial to mesenchymal transition, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4929-4936. doi:https://doi.org/10.1167/iovs.18-24299
Failure of Autophagy–Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6nclf Mice Open Access
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Philipp von Eisenhart-Rothe; Alexandra Grubman; Ursula Greferath; Linda J. Fothergill; Andrew I. Jobling; Joanna A. Phipps; Anthony R. White; Erica L. Fletcher; Kirstan A. Vessey
Tags: autophagy, mice, photoreceptors, rod photoreceptors, retinal degeneration
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5082-5097. doi:https://doi.org/10.1167/iovs.18-24757

Visual Neuroscience

Temporal Frequency Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Electroretinography Open Access
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J. Jason McAnany; Jason C. Park
Tags: diabetes mellitus, diabetic retinopathy, electroretinography, nonproliferative diabetic retinopathy, photopsia
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4871-4879. doi:https://doi.org/10.1167/iovs.18-25199
Binocular Summation in Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells Open Access
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Marija Zivcevska; Alan Blakeman; Shaobo Lei; Herbert C. Goltz; Agnes M. F. Wong
Tags: melanopsin, pupil reaction, retinal ganglion cells, summation
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4968-4977. doi:https://doi.org/10.1167/iovs.18-24639

Visual Psychophysics and Physiological Optics

Glaucoma Affects Viewing Distance for Recognition of Sex and Facial Expression Open Access
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Audrey Schafer; Jean François Rouland; Carole Peyrin; Sebastien Szaffarczyk; Muriel Boucart
Tags: facial expression, facial recognition, glaucoma, face
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4921-4928. doi:https://doi.org/10.1167/iovs.18-24875
On Sensory Eye Dominance Revealed by Binocular Integrative and Binocular Competitive Stimuli Open Access
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Chao Han; Zijiang J. He; Teng Leng Ooi
Tags: eye, ocular dominance, imbalance
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5140-5148. doi:https://doi.org/10.1167/iovs.18-24342
Effect of Optical Defocus on Choroidal Thickness in Healthy Adults With Presbyopia Open Access
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Samuel T.-H. Chiang; Tzu-Lan Chen; John R. Phillips
Tags: adult, optics, presbyopia, eye
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5188-5193. doi:https://doi.org/10.1167/iovs.18-24815

Review

Ocular Clocks: Adapting Mechanisms for Eye Functions and Health Open Access
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Marie-Paule Felder-Schmittbuhl; Ethan D. Buhr; Ouria Dkhissi-Benyahya; David Hicks; Stuart N. Peirson; Christophe P. Ribelayga; Cristina Sandu; Rainer Spessert; Gianluca Tosini
Tags: circadian clocks, dopamine, eye, health, melatonin
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4856-4870. doi:https://doi.org/10.1167/iovs.18-24957

Perspective

Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members Open Access
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W. Daniel Stamer; Andrew M. Williams; Stephen Pflugfelder; Sarah E. Coupland
Tags: body tissue, eye, surveys, research personnel
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 4783-4792. doi:https://doi.org/10.1167/iovs.18-25319

Letters to the Editor

Influencing Factors Relating the Demarcation Line Depth and Efficacy of Corneal Crosslinking Open Access
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Jui-teng Lin
Tags: corneal collagen cross-linking
Investigative Ophthalmology & Visual Science October 2018, Vol.59, 5125-5126. doi:https://doi.org/10.1167/iovs.18-25244
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