Volume 59 Issue 15 | IOVS

Color and Temporal Frequency Sensitive Eye Growth in Chick Open Access

Frances Rucker; Stephanie Britton; Christopher Taylor

Tags: color, eye, lighting, photopsia, refraction

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6003-6013. doi:https://doi.org/10.1167/iovs.18-25322

Biochemistry and Molecular Biology

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs Open Access

PDF

Miaozhen Pan; Shiming Jiao; Peter S. Reinach; Jiaofeng Yan; Yanan Yang; Qihang Li; Nethrajeith Srinivasalu; Jia Qu; Xiangtian Zhou

Tags: eye, myopia, ppar alpha, bezafibrate, caviidae

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5803-5815. doi:https://doi.org/10.1167/iovs.17-22297

Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease Open Access

PDF

Anastasia Marie Litke; Sarah Samuelson; Kerry R. Delaney; Yves Sauvé; Robert L. Chow

Tags: cornea, corneal diseases, diagnostic imaging, mice, missense mutation

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5824-5835. doi:https://doi.org/10.1167/iovs.18-25490

The Effect of Prostaglandin Analogue Bimatoprost on Thyroid-Associated Orbitopathy Open Access

PDF

Catherine J. Choi; Wensi Tao; Ravi Doddapaneni; Zenith Acosta-Torres; Nathan W. Blessing; Bradford W. Lee; Daniel Pelaez; Sara T. Wester

Tags: bimatoprost, prostaglandins, synthetic

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5912-5923. doi:https://doi.org/10.1167/iovs.18-25134

Clinical and Epidemiologic Research

Potential Role of Ocular Microbiome, Host Genotype, Tear Cytokines, and Environmental Factors in Corneal Infiltrative Events in Contact Lens Wearers Open Access

PDF

Cecilia Chao; Lakshmi Akileswaran; Jessica N. Cooke Bailey; Mark Willcox; Russell Van Gelder; Carol Lakkis; Fiona Stapleton; Kathryn Richdale

Tags: contact lenses, cornea, cytokine, environmental factors, genotype

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5752-5761. doi:https://doi.org/10.1167/iovs.18-24845

Clinically Relevant Immune-Cellular Metrics of Inflammation in Meibomian Gland Dysfunction Open Access

PDF

Yureeda Qazi; Ahmad Kheirkhah; Caroline Blackie; Monique Trinidad; Candice Williams; Andrea Cruzat; Donald R. Korb; Pedram Hamrah

Tags: eyelid, inflammation, meibomian gland, conjunctiva, pathophysiology

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6111-6123. doi:https://doi.org/10.1167/iovs.18-25571

Cornea

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes Open Access

PDF

Kiyokazu Ozaki; Yui Terayama; Tetsuro Matsuura

Tags: alloxan, cornea, diabetes mellitus, type 1, hyperglycemia, mice

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5868-5875. doi:https://doi.org/10.1167/iovs.18-25693

Prevention of Corneal Neovascularization by Adenovirus Encoding Human Vascular Endothelial Growth Factor Soluble Receptor (s-VEGFR1) in Lacrimal Gland Open Access

PDF

Luis Fernando Nominato; Ana Carolina Dias; Lara Cristina Dias; Marina Zilio Fantucci; Lilian Eslaine Costa Mendes da Silva; Adriana de Andrade Murashima; Eduardo Melani Rocha

Tags: adenoviruses, alkalies, burns, cornea, corneal neovascularization

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6036-6044. doi:https://doi.org/10.1167/iovs.17-22322

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Binocular Summation for Reflexive Eye Movements: A Potential Diagnostic Tool for Stereodeficiencies Open Access

PDF

Christian Quaia; Edmond J. FitzGibbon; Lance M. Optican; Bruce G. Cumming

Tags: clinical diagnostic instrument, eye, eye movement, summation, vision

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5816-5822. doi:https://doi.org/10.1167/iovs.18-24520

Genetics

Longitudinal Assessment of Retinal Structure in Achromatopsia Patients With Long-Term Follow-up Open Access

PDF

Nashila Hirji; Michalis Georgiou; Angelos Kalitzeos; James W. Bainbridge; Neruban Kumaran; Jonathan Aboshiha; Joseph Carroll; Michel Michaelides

Tags: achromatopsia, follow-up, retina, spectral domain-optical coherence tomography, cohort studies

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5735-5744. doi:https://doi.org/10.1167/iovs.18-25452

Glaucoma

Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns Open Access

PDF

Siamak Yousefi; Hiroshi Sakai; Hiroshi Murata; Yuri Fujino; Masato Matsuura; David Garway-Heath; Robert Weinreb; Ryo Asaoka

Tags: open-angle glaucoma, eye, visual fields, blindness, angle closure glaucoma

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5717-5725. doi:https://doi.org/10.1167/iovs.18-25140

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma Open Access

PDF

Youn Hye Jo; Kyung Rim Sung; Sung-Cheol Yun

Tags: angle closure glaucoma, open-angle glaucoma, visual fields, eye, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5862-5867. doi:https://doi.org/10.1167/iovs.18-25423

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma Open Access

PDF

Emily Mathieu; Neeru Gupta; Luz A. Paczka-Giorgi; Xun Zhou; Amir Ahari; Rafael Lani; Joseph Hanna; Yeni H. Yücel

Tags: glaucoma, optic nerve, cerebrospinal fluid

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5876-5884. doi:https://doi.org/10.1167/iovs.18-24521

Δ⁹-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure Open Access

PDF

Sally Miller; Laura Daily; Emma Leishman; Heather Bradshaw; Alex Straiker

Tags: cannabidiol, intraocular pressure, tetrahydrocannabinol, eye, cannabinoids

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5904-5911. doi:https://doi.org/10.1167/iovs.18-24838

Immunology and Microbiology

Mechanism of Pseudomonas aeruginosa Small Protease (PASP), a Corneal Virulence Factor Open Access

PDF

Aihua Tang; Armando R. Caballero; Mary E. Marquart; Michael A. Bierdeman; Richard J. O'Callaghan

Tags: cornea, endopeptidases, peptide hydrolases, proteins, serine proteases

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5993-6002. doi:https://doi.org/10.1167/iovs.18-25834

Lens

Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells Open Access

PDF

Laura Wernecke; Susanne Keckeis; Nadine Reichhart; Olaf Strauß; Daniel J. Salchow

Tags: cell transdifferentiation, child, epithelium, lens epithelial cell, patient characteristics

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5785-5794. doi:https://doi.org/10.1167/iovs.18-23789

Multidisciplinary Ophthalmic Imaging

Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic Open Access

PDF

Charles E. Granger; Qiang Yang; Hongxin Song; Kenichi Saito; Koji Nozato; Lisa R. Latchney; Bianca T. Leonard; Mina M. Chung; David R. Williams; Ethan A. Rossi

Tags: autofluorescence, diagnostic imaging, mosaicism, photoreceptors, retinal cone

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5705-5716. doi:https://doi.org/10.1167/iovs.18-24677

Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography Open Access

PDF

Julia Hafner; Matthias Salas; Christoph Scholda; Wolf-Dieter Vogl; Wolfgang Drexler; Ursula Schmidt-Erfurth; Michael Pircher; Sonja Karst

Tags: diabetes mellitus, diabetes mellitus, type 2, diagnostic imaging, macrophage activation syndrome, meconium aspiration syndrome

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5932-5940. doi:https://doi.org/10.1167/iovs.18-24573

Retina

Optical Coherence Tomography Angiography in Familial Exudative Vitreoretinopathy: Clinical Features and Phenotype-Genotype Correlation Open Access

PDF

Chonglin Chen; Chengxi Liu; Zhirong Wang; Limei Sun; Xiujuan Zhao; Songshan Li; Xiaoling Luo; Aiyuan Zhang; Victor Chong; Lin Lu; Xiaoyan Ding

Tags: familial exudative vitreoretinopathies, phenotype, angiogram, genotype, signs and symptoms

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5726-5734. doi:https://doi.org/10.1167/iovs.18-25377

Cross-Sectional Imaging Analysis of Epiretinal Membrane Involvement in Unilateral Open-Angle Glaucoma Severity Open Access

PDF

Susumu Sakimoto; Tomoyuki Okazaki; Shinichi Usui; Tomoyuki Ishibashi; Yoshihito Oura; Kentaro Nishida; Atsuya Miki; Ryo Kawasaki; Kenji Matsushita; Hirokazu Sakaguchi; Kohji Nishida

Tags: diagnostic imaging, epiretinal membrane, glaucoma, open-angle glaucoma

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5745-5751. doi:https://doi.org/10.1167/iovs.18-25292

Blue Cone Monochromacy Caused by the C203R Missense Mutation or Large Deletion Mutations Open Access

PDF

Alexander Sumaroka; Alexandra V. Garafalo; Artur V. Cideciyan; Jason Charng; Alejandro J. Roman; Windy Choi; Supna Saxena; Valeryia Aksianiuk; Susanne Kohl; Bernd Wissinger; Samuel G. Jacobson

Tags: genotype, missense mutation, mutation, retinal cone, cohort studies

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5762-5772. doi:https://doi.org/10.1167/iovs.18-25280

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure Open Access

PDF

Mingzhe Cao; Jiamin Ouyang; Huilin Liang; Jingyi Guo; Siyuan Lin; Shulan Yang; Ting Xie; Shuyi Chen

Tags: fissure, gene expression profiling, genes, optics, zebrafish

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5773-5784. doi:https://doi.org/10.1167/iovs.18-23962

Functional Characterization of Abicipar-Pegol, an Anti-VEGF DARPin Therapeutic That Potently Inhibits Angiogenesis and Vascular Permeability Open Access

PDF

Gerard A. Rodrigues; Matthew Mason; Lori-Ann Christie; Candice Hansen; Lisa M. Hernandez; James Burke; Keith A. Luhrs; Thomas C. Hohman

Tags: angiogenesis, anti-vascular endothelial growth factor therapy, ranibizumab, vascular endothelial growth factor a, affinity

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5836-5846. doi:https://doi.org/10.1167/iovs.18-25307

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit Open Access

PDF

Yuki Muraoka; Akihito Uji; Masaharu Ishikura; Yuto Iida; Sotaro Ooto; Akitaka Tsujikawa

Tags: angiogram, blood capillaries, microcirculation, optical coherence tomography, retinal vasculature

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5847-5853. doi:https://doi.org/10.1167/iovs.18-25301

Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent Open Access

PDF

Ryohei Miyata; Mineo Kondo; Kumiko Kato; Masahiko Sugimoto; Hisashi Matsubara; Kengo Ikesugi; Shinji Ueno; Shunsuke Yasuda; Hiroko Terasaki

Tags: electroretinography, eye, photopsia, anti-vascular endothelial growth factor therapy, central retinal vein occlusion

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5854-5861. doi:https://doi.org/10.1167/iovs.18-25087

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis Open Access

PDF

Brandon Bosse; Samir Damle; Abraham Akinin; Yi Jing; Dirk-Uwe Bartsch; Lingyun Cheng; Nicholas Oesch; Yu-Hwa Lo; Gert Cauwenberghs; William R. Freeman

Tags: implants, nanowires, retina, silicon, visual prosthesis

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5885-5892. doi:https://doi.org/10.1167/iovs.18-24554

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography Open Access

PDF

Shota Yasukura; Tomoaki Murakami; Kiyoshi Suzuma; Tatsuya Yoshitake; Hideo Nakanishi; Masahiro Fujimoto; Maho Oishi; Akitaka Tsujikawa

Tags: angiogram, arteriole, diabetes mellitus, optical coherence tomography, perfusion

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5893-5903. doi:https://doi.org/10.1167/iovs.18-25108

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy Open Access

PDF

Nobuhiro Terao; Hideki Koizumi; Kentaro Kojima; Tetsuya Yamagishi; Kenji Nagata; Koji Kitazawa; Yuji Yamamoto; Kengo Yoshii; Asako Hiraga; Munetoyo Toda; Shigeru Kinoshita; Chie Sotozono; Junji Hamuro

Tags: central serous chorioretinopathy, cytokine, hypertension, angiogenesis, choroid

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5924-5931. doi:https://doi.org/10.1167/iovs.18-25517

Prospective Evaluation of Patients With X-Linked Retinoschisis During 18 Months Open Access

PDF

Mark E. Pennesi; David G. Birch; K. Thiran Jayasundera; Maria Parker; Ou Tan; Rabia Gurses-Ozden; Carrie Reichley; Kathleen N. Beasley; Paul Yang; Richard G. Weleber; Lea D. Bennett; John R. Heckenlively; Kalyani Kothapalli; Jeffrey D. Chulay; for the XLRS-001 Study Group

Tags: cysts, electroretinography, eye, perimetry, vision

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5941-5956. doi:https://doi.org/10.1167/iovs.18-24565

OCT Angiography and Cone Photoreceptor Imaging in Geographic Atrophy Open Access

PDF

Jia Qin; Nicholas Rinella; Qinqin Zhang; Hao Zhou; Jessica Wong; Michael Deiner; Austin Roorda; Travis C. Porco; Ruikang K. Wang; Daniel M. Schwartz; Jacque L. Duncan

Tags: angiogram, atrophy, chief complaint, diagnostic imaging, eye

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5985-5992. doi:https://doi.org/10.1167/iovs.18-25032

Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice Open Access

PDF

Helen T. Michael; Cari Graff-Cherry; Sung Chin; Corinne Rauck; Amelework D. Habtemichael; Patricia Bunda; Tunde Smith; Maria M. Campos; Kapil Bharti; Heinz Arnheiter; Glenn Merlino; Chi-Ping Day

Tags: ectopic gene expression, eye, mice, mitf protein, pigment

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6067-6073. doi:https://doi.org/10.1167/iovs.18-25186

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3 Open Access

PDF

Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren

Tags: achromatopsia, mice, retinal cone, electroretinography, mutation

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6102-6110. doi:https://doi.org/10.1167/iovs.18-24328

Retinal Cell Biology

RF/6A Chorioretinal Cells Do Not Display Key Endothelial Phenotypes Open Access

PDF

Ryan D. Makin; Ivana Apicella; Yosuke Nagasaka; Hiroki Kaneko; Stephen D. Turner; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand

Tags: endothelial cells, endothelium, phenotype

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5795-5802. doi:https://doi.org/10.1167/iovs.18-25215

Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo Open Access

PDF

Bruce A. Berkowitz; Robert H. Podolsky; Haohua Qian; Yichao Li; Ke Jiang; Jacob Nellissery; Anand Swaroop; Robin Roberts

Tags: diagnostic imaging, magnetic resonance imaging, mice, mitochondria, respiration

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5957-5964. doi:https://doi.org/10.1167/iovs.18-25682

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy Open Access

PDF

Brian Song; Dongjoon Kim; Ngan-Ha Nguyen; Sayon Roy

Tags: diabetes mellitus, diabetic retinopathy, protein overexpression, protein-lysine 6-oxidase, rna, small interfering

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5965-5972. doi:https://doi.org/10.1167/iovs.18-25543

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration Open Access

PDF

Wenyi Tang; Jun Ma; Ruiping Gu; Boya Lei; Xinyi Ding; Gezhi Xu

Tags: apoptosis, lcn2 gene, lentivirus, lipocalin-2 protein, photoreceptors

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6014-6025. doi:https://doi.org/10.1167/iovs.18-25213

Granulin 1 Promotes Retinal Regeneration in Zebrafish Open Access

PDF

Kazuhiro Tsuruma; Yuichi Saito; Hiroyuki Okuyoshi; Akihiro Yamaguchi; Masamitsu Shimazawa; Daniel Goldman; Hideaki Hara

Tags: bromodeoxyuridine, grn gene, retina, zebrafish, genes

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6057-6066. doi:https://doi.org/10.1167/iovs.18-24828

A Combination Therapy Targeting Endoglin and VEGF-A Prevents Subretinal Fibro-Neovascularization Caused by Induced Müller Cell Disruption Open Access

PDF

Weiyong Shen; So-Ra Lee; Michelle Yam; Ling Zhu; Ting Zhang; Victoria Pye; Ashish Easow Mathai; Keiichi Shibagaki; Jin-Zhong Zhang; Takeshi Matsugi; Mark C. Gillies

Tags: endoglin, neovascularization, pathologic, vascular endothelial growth factor a, antibodies, combined modality therapy

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6075-6088. doi:https://doi.org/10.1167/iovs.18-25628

Photoreceptor Progenitors Depend Upon Coordination of gdf6a, thrβ, and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes Open Access

PDF

Michèle G. DuVal; W. Ted Allison

Tags: burkina faso, photoreceptors, retinal cone, ultraviolet rays, zebrafish

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6089-6101. doi:https://doi.org/10.1167/iovs.18-24461

Visual Neuroscience

Effect of Stimulus Intensity and Visual Field Location on Rod- and Cone-Mediated Pupil Response to Focal Light Stimuli Open Access

PDF

Soad Haj Yahia; Amit Hamburg; Ifat Sher; Daniel Ben Ner; Saeed Yassin; Ron Chibel; Michael Mimouni; Estela Derazne; Michael Belkin; Ygal Rotenstreich

Tags: pupil reaction, retinal cone, rod photoreceptors, visual fields, blue light

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6027-6035. doi:https://doi.org/10.1167/iovs.18-23767

Optic Nerve Degeneration and Reduced Contrast Sensitivity Due to Folic Acid Deficiency: A Behavioral and Electrophysiological Study in Rhesus Monkeys Open Access

PDF

Elisa Santandrea; Ilaria Sani; Gianpaolo Morbioli; Domenico Multari; Giorgio Marchini; Leonardo Chelazzi

Tags: cercopithecidae, contrast sensitivity, electrophysiological studies, folic acid deficiency, macaca mulatta

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6045-6056. doi:https://doi.org/10.1167/iovs.18-24822

Visual Psychophysics and Physiological Optics

Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared Open Access

PDF

Christina Schwarz; Robin Sharma; Soon Keen Cheong; Matthew Keller; David R. Williams; Jennifer J. Hunter

Tags: lasers, retinal cone, photoreceptors, diagnostic imaging

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5973-5984. doi:https://doi.org/10.1167/iovs.18-25383

Erratum

Erratum Open Access

PDF

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 5823. doi:https://doi.org/10.1167/iovs.15-17059a

Erratum Open Access

PDF

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6026. doi:https://doi.org/10.1167/iovs.18-24707a

Erratum Open Access

PDF

Investigative Ophthalmology & Visual Science December 2018, Vol.59, 6074. doi:https://doi.org/10.1167/iovs.18-24674a

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.