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Anatomy and Pathology/Oncology

The Association Between Retinopathy of Prematurity and Ocular Growth Open Access
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Dimitrios Kardaras; Eleni Papageorgiou; Katerina Gaitana; Ioanna Grivea; Vasileios A. Dimitriou; Sofia Androudi; Antonios Gounaris; Evangelia E. Tsironi
Tags: infant, retinopathy of prematurity, body weight, eye, risk factors
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 98-106. doi:10.1167/iovs.18-24776

Biochemistry and Molecular Biology

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts Open Access
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Sun Woong Kim; Hye-In Kim; Bikash Thapa; Selikem Nuwromegbe; Keunwook Lee
Tags: fibroblasts, mechanistic target of rapamycin complex 2, mtor serine-threonine kinases, proto-oncogene proteins c-akt, pterygium
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 82-92. doi:10.1167/iovs.18-25376
Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers Open Access
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Saima Limi; Yilin Zhao; Peng Guo; Melissa Lopez-Jones; Deyou Zheng; Robert H. Singer; Arthur I. Skoultchi; Ales Cvekl
Tags: crystallins, genes, lens (device), lens, crystalline, rna, messenger
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 234-244. doi:10.1167/iovs.18-25921

Clinical and Epidemiologic Research

Preschool Children Exhibit Evident Compensatory Role of Internal Astigmatism in Distribution of Astigmatism: The Nanjing Eye Study Open Access
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Zijin Wang; Dan Huang; Xuejuan Chen; Hui Zhu; Qigang Sun; Yue Wang; Xiaohan Zhang; Yue Wang; Leili Zhai; Chenyang Wang; Hu Liu
Tags: astigmatism, eye, preschool child
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 73-81. doi:10.1167/iovs.18-24799
Randomized, Controlled, Double-Masked, Multicenter, Pilot Study Evaluating Safety and Efficacy of Intranasal Neurostimulation for Dry Eye Disease Open Access
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Geoffrey S. Cohn; Dean Corbett; Abi Tenen; Minas Coroneo; James McAlister; Jennifer P. Craig; Trevor Gray; David Kent; Neil Murray; Con Petsoglou; Stephanie N. Baba; Edward J. Holland
Tags: dry eye syndromes, pilot projects, safety, tear production
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 147-153. doi:10.1167/iovs.18-23984
Longitudinal Changes in Spherical Equivalent Refractive Error Among Children With Preschool Myopia Open Access
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Yin Hu; Xiaohu Ding; Wen Long; Mingguang He; Xiao Yang
Tags: child, myopia, preschools, refraction, refractive errors
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 154-160. doi:10.1167/iovs.18-24862

Cornea

MiR-34c Participates in Diabetic Corneal Neuropathy Via Regulation of Autophagy Open Access
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Jianzhang Hu; XinYing Hu; Tong Kan
Tags: autophagy, cornea, diabetes mellitus, neurons, neuropathy
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 16-25. doi:10.1167/iovs.18-24968
Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography Open Access
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Brecken J. Blackburn; Shi Gu; Matthew R. Ford; Vinícius de Stefano; Michael W. Jenkins; William J. Dupps, Jr; Andrew M. Rollins
Tags: cornea, corneal collagen cross-linking, diagnostic imaging, eye, motion
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 41-51. doi:10.1167/iovs.18-25535
Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro Open Access
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Sheyla González; Denise Oh; Elfren R. Baclagon; Jie J. Zheng; Sophie X. Deng
Tags: molecule, regulation, signal transduction, stem cells, small molecule
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 107-112. doi:10.1167/iovs.18-25740
The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium Open Access
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Abdulhakeem S. Alamri; James A. Brock; Chandana B. Herath; Indu G. Rajapaksha; Peter W. Angus; Jason J. Ivanusic
Tags: cold sensation, cold temperature, common cold, cornea, corneal epithelium
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 209-217. doi:10.1167/iovs.18-25788
Identification of Leukocytes Associated With Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers Open Access
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Cameron K. Postnikoff; Andrew D. Pucker; John Laurent; Carrie Huisingh; Gerald McGwin; Jason J. Nichols
Tags: contact lenses, lens (device), lens, crystalline, leukocytes, sclera
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 226-233. doi:10.1167/iovs.18-24664
Epithelial Membrane Protein-2 (EMP2) Antibody Blockade Reduces Corneal Neovascularization in an In Vivo Model Open Access
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Michel M. Sun; Ann M. Chan; Samuel M. Law; Sergio Duarte; Daniel Diaz-Aguilar; Madhuri Wadehra; Lynn K. Gordon
Tags: antibodies, corneal neovascularization, epithelium, proteins, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 245-254. doi:10.1167/iovs.18-24345
The Protective Effect of a Topical Mucin Secretagogue on Ocular Surface Damage Induced by Airborne Carbon Black Exposure Open Access
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Xiangzhe Li; Boram Kang; Youngsub Eom; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song
Tags: carbon, cervical lymph node group, mucins, prevention, secretagogues
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 255-264. doi:10.1167/iovs.18-25964

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Optical Coherence Tomography Angiography in Papilledema Compared With Pseudopapilledema Open Access
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Masoud Aghsaei Fard; Alireza Sahraiyan; Jalil Jalili; Marjane Hejazi; Yanin Suwan; Robert Ritch; Prem S. Subramanian
Tags: angiogram, optical coherence tomography, papilledema, pseudopapilledema, eye
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 168-175. doi:10.1167/iovs.18-25453

Genetics

Germline Mutations in CTNNB1 Associated With Syndromic FEVR or Norrie Disease Open Access
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Wenmin Sun; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Panfeng Wang; Qingjiong Zhang
Tags: beta catenin, congenital progressive oculo-acoustico-cerebral degeneration, familial exudative vitreoretinopathy, germ-line mutation, mutation
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 93-97. doi:10.1167/iovs.18-25142

Glaucoma

Evidence of Hypoxic Glial Cells in a Model of Ocular Hypertension Open Access
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Assraa H. Jassim; Denise M. Inman
Tags: hypoxia, neuroglia, ocular hypertension, proteins, retina
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 1-15. doi:10.1167/iovs.18-24977
Identification of Candidate miRNA Biomarkers for Glaucoma Open Access
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Allyson G. Hindle; Robrecht Thoonen; Jessica V. Jasien; Robert M. H. Grange; Krishna Amin; Jasen Wise; Mineo Ozaki; Robert Ritch; Rajeev Malhotra; Emmanuel S. Buys
Tags: biological markers, glaucoma, micrornas, plasma
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 134-146. doi:10.1167/iovs.18-24878
Comparison of Rates of Fast and Catastrophic Visual Field Loss in Three Glaucoma Subtypes Open Access
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Andrew J. Anderson; Abadh K. Chaurasia; Ajay Sharma; Amisha Gupta; Shikha Gupta; Anurag Khanna; Viney Gupta
Tags: blindness, glaucoma, visual fields, cohort studies, open-angle glaucoma
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 161-167. doi:10.1167/iovs.18-25391
Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway Open Access
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Yiwen Wang; Deborah Osakue; Enzhi Yang; Yi Zhou; Haiyan Gong; Xiaobo Xia; Yiqin Du
Tags: stress, stress response, stem cells, endoplasmic reticulum, trabecular meshwork
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 265-273. doi:10.1167/iovs.18-25477

Immunology and Microbiology

Effect of Interferon alfa-2a Treatment on Adaptive and Innate Immune Systems in Patients With Behçet Disease Uveitis Open Access
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Ozgur Albayrak; Merih Oray; Fusun Can; Gunay Uludag Kirimli; Ahmet Gul; Ilknur Tugal-Tutkun; Sumru Onal
Tags: interferon alfa-2a, uveitis, disease remission, behcet syndrome, antigens, cd25
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 52-63. doi:10.1167/iovs.18-25548

Lens

An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation Open Access
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Julie A. Eldred; Jiyun Zheng; Sulin Chen; I. Michael Wormstone
Tags: cell growth, lens, crystalline, cataract surgery, surgical procedures, operative, donors
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 113-122. doi:10.1167/iovs.18-25930

Multidisciplinary Ophthalmic Imaging

Spectrally Resolved Fundus Autofluorescence in ABCA4-Related Retinopathy Open Access
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Chantal Dysli; Philipp L. Müller; Johannes Birtel; Frank G. Holz; Philipp Herrmann
Tags: fundus autofluorescence imaging, retinal diseases, diagnostic imaging, color
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 274-281. doi:10.1167/iovs.18-25755

Physiology and Pharmacology

Regulation of Choroidal Blood Flow During Isometric Exercise at Different Levels of Intraocular Pressure Open Access
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Alina Popa-Cherecheanu; Doreen Schmidl; René M. Werkmeister; Jacqueline Chua; Gerhard Garhöfer; Leopold Schmetterer
Tags: exercise, isometric, intraocular pressure, regulation, vascular flow, suction drainage
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 176-182. doi:10.1167/iovs.18-24992

Retina

Analysis of Retinal Segmentation Changes at High Altitude With and Without Acetazolamide Open Access
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Alexander Kenneth Clarke; Mariano Cozzi; Christopher Henry Ernest Imray; Alex Wright; Sergio Pagliarini; for the Birmingham Medical Research Expeditionary Society
Tags: acetazolamide, high altitude, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 36-40. doi:10.1167/iovs.18-24966
Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration Open Access
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Marie Krogh Nielsen; Yousif Subhi; Christopher Rue Molbech; Mads Krüger Falk; Mogens Holst Nissen; Torben Lykke Sørensen
Tags: age-related macular degeneration, atrophy, interleukin-6, plasma, atrophic condition of skin
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 202-208. doi:10.1167/iovs.18-25878
VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site Open Access
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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
Tags: histopathology tests, mutation, proteins, proteolysis, splice-site mutation
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 282-293. doi:10.1167/iovs.18-25624
Exosomes Derived From Mesenchymal Stem Cells Modulate miR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation Via Targeting HMGB1 Open Access
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Wei Zhang; Yang Wang; Yichun Kong
Tags: exosomes, hmgb1 protein, hyperglycemia, inflammation, retinitis
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 294-303. doi:10.1167/iovs.18-25617
Identification and Quantification of the Angiofibrotic Switch in Neovascular AMD Open Access
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Philipp K. Roberts; Stefan Zotter; Alessio Montuoro; Michael Pircher; Bernhard Baumann; Markus Ritter; Christoph K. Hitzenberger; Ursula Schmidt-Erfurth
Tags: anti-vascular endothelial growth factor therapy, choroidal neovascularization, diagnostic imaging, exudative age-related macular degeneration, eye
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 304-311. doi:10.1167/iovs.18-25189

Retinal Cell Biology

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ Open Access
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Carsten Faber; Helene Bæk Juel; Benjamin Anderschou Holbech Jensen; Jan Pravsgaard Christensen; Jan Ulrik Prause; Allan Randrup Thomsen; Mogens Holst Nissen
Tags: chemokines, choroid, infection, interferons, lymphocytic choriomeningitis virus
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 192-201. doi:10.1167/iovs.18-25721

Visual Neuroscience

Cone Photoreceptor Dysfunction in Early-Stage Diabetic Retinopathy: Association Between the Activation Phase of Cone Phototransduction and the Flicker Electroretinogram Open Access
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J. Jason McAnany; Jason C. Park
Tags: diabetes mellitus, diabetic retinopathy, electroretinography, photopsia, phototransduction
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 64-72. doi:10.1167/iovs.18-25946
Retinal Deficits Precede Cognitive and Motor Deficits in a Rat Model of Type II Diabetes Open Access
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Rachael S. Allen; Andrew Feola; Cara T. Motz; Amy L. Ottensmeyer; Kyle C. Chesler; Ryan Dunn; Peter M. Thulé; Machelle T. Pardue
Tags: diabetes mellitus, type 2, electroretinography, hyperglycemia, motor deficits, rats
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 123-133. doi:10.1167/iovs.18-25110
Retinal Characterization of the Thy1-GCaMP3 Transgenic Mouse Line After Optic Nerve Transection Open Access
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Stephanie N. Blandford; Michele L. Hooper; Takeshi Yabana; Balwantray C. Chauhan; William H. Baldridge; Spring R. M. Farrell
Tags: calcium, diagnostic imaging, mice, transgenic, optic nerve, retina
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 183-191. doi:10.1167/iovs.18-25861
The Effect of Atropine on Human Global Flash mfERG Responses to Retinal Defocus Open Access
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Safal Khanal; Philip R. K. Turnbull; Nicholas Lee; John R. Phillips
Tags: atropine
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 218-225. doi:10.1167/iovs.18-24600

Review

Pulling and Tugging on the Retina: Mechanical Impact of Glaucoma Beyond the Optic Nerve Head Open Access
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Brad Fortune
Tags: glaucoma, optic disk, retina, cysts, mechanical impact
Investigative Ophthalmology & Visual Science January 2019, Vol.60, 26-35. doi:10.1167/iovs.18-25837
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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