Volume 60 Issue 4 | IOVS

Anatomy and Pathology/Oncology

Rabbit Model of Intra-Arterial Chemotherapy Toxicity Demonstrates Retinopathy and Vasculopathy Related to Drug and Dose, Not Procedure or Approach Open Access

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Anthony B. Daniels; Michael T. Froehler; Amy H. Nunnally; Janene M. Pierce; Ivan Bozic; Cameron A. Stone; Pranav R. Santapuram; Yuankai K. Tao; Kelli L. Boyd; Lauren E. Himmel; Sheau-chiann Chen; Liping Du; Debra L. Friedman; Ann Richmond

Tags: melphalan, oryctolagus cuniculus, toxic effect, retinal diseases, eye

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 954-964. doi:https://doi.org/10.1167/iovs.18-25346

Strain-Dependent Differences in Sensitivity to Myopia-Inducing Stimuli in Guinea Pigs and Role of Choroid Open Access

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Liqin Jiang; Mariana B. Garcia; David Hammond; Dinasha Dahanayake; Christine F. Wildsoet

Tags: caviidae, choroid, eye, myopia, optics

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1226-1233. doi:https://doi.org/10.1167/iovs.18-25365

Biochemistry and Molecular Biology

Electrophysiological Changes During Early Steps of Retinitis Pigmentosa Open Access

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Ulisse Bocchero; Beatrice M. Tam; Colette N. Chiu; Vincent Torre; Orson L. Moritz

Tags: retinitis pigmentosa, rhodopsin, rod photoreceptors, phototransduction, electroretinography

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 933-943. doi:https://doi.org/10.1167/iovs.18-25347

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts Open Access

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao

Tags: bromfenac, fibroblasts, hpfs trial, pterygium, conjunctiva

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1156-1164. doi:https://doi.org/10.1167/iovs.18-24743

Clinical and Epidemiologic Research

Progression of Myopic Maculopathy in Highly Myopic Chinese Eyes Open Access

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Zhixi Li; Ran Liu; Ou Xiao; Xinxing Guo; Decai Wang; Jian Zhang; Jason James Ha; Jonathan Tak Loong Lee; Peiying Lee; Monica Jong; Padmaja Sankaridurg; Kyoko Ohno-Matsui; Mingguang He

Tags: eye, macular disorders, chinese (other dialects), chinese people

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1096-1104. doi:https://doi.org/10.1167/iovs.18-25800

Cornea

Mediators of Corneal Haze Following Implantation of Presbyopic Corneal Inlays Open Access

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Beau J. Fenner; Yu-Chi Liu; Siew Kwan Koh; Yan Gao; Lu Deng; Roger W. Beuerman; Lei Zhou; Julian T. S. Theng; Jodhbir S. Mehta

Tags: cornea, corneal opacity, implantation procedure, proteins, proteomics

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 868-876. doi:https://doi.org/10.1167/iovs.18-25761

Descemet's Membrane Modulation of Posterior Corneal Fibrosis Open Access

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Carla S. Medeiros; Paramananda Saikia; Rodrigo Carlos de Oliveira; Luciana Lassance; Marcony R. Santhiago; Steven E. Wilson

Tags: cicatrix, cornea, descemet's membrane, endothelium, fibrosis

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1010-1020. doi:https://doi.org/10.1167/iovs.18-26451

Hyaluronan Derived From the Limbus is a Key Regulator of Corneal Lymphangiogenesis Open Access

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Mingxia Sun; Sudan Puri; Kazadi N. Mutoji; Yvette M. Coulson-Thomas; Vincent C. Hascall; David G. Jackson; Tarsis F. Gesteira; Vivien J. Coulson-Thomas

Tags: cornea, lymphangiogenesis, lymphatic vessels, hyaluronan, mice

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1050-1062. doi:https://doi.org/10.1167/iovs.18-25920

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease Open Access

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang

Tags: desiccation, mucins, stress, eye, cornea

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1076-1087. doi:https://doi.org/10.1167/iovs.18-24935

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice Open Access

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon

Tags: dry eye syndromes, mice, rapamycin, stress, endoplasmic reticulum

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1254-1264. doi:https://doi.org/10.1167/iovs.18-25583

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Vestibular Eye Movements Are Heavily Impacted by Visual Motion and Are Sensitive to Changes in Visual Intensities Open Access

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Tobias Wibble; Tony Pansell

Tags: eye movement, motion, musculoskeletal torsion, function, torsion, photic stimulation

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1021-1027. doi:https://doi.org/10.1167/iovs.19-26706

Retinal Microvasculature in Amblyopic Children and the Quantitative Relationship Between Retinal Perfusion and Thickness Open Access

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Wuhe Chen; Jiangtao Lou; Frank Thorn; Yingjie Wang; Jieli Mao; Qingya Wang; Xinping Yu

Tags: amblyopia, child, perfusion, retinal vasculature, eye

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1185-1191. doi:https://doi.org/10.1167/iovs.18-26416

Visual Function and Disability Are Associated With Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer in Patients With Multiple Sclerosis Open Access

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Ce Shi; Hong Jiang; Giovana Rosa Gameiro; Huiling Hu; Jeffrey Hernandez; Silvia Delgado; Jianhua Wang

Tags: disability, eye, ganglia, multiple sclerosis, vision

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1213-1223. doi:https://doi.org/10.1167/iovs.18-25809

Genetics

Progressive Characterization of Visual Phenotype in Bardet-Biedl Syndrome Mutant Mice Open Access

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Viola Kretschmer; Sarita Rani Patnaik; Friedrich Kretschmer; Mira Manilal Chawda; Victor Hernandez-Hernandez; Helen Louise May-Simera

Tags: mice, phenotype, bardet-biedl syndrome

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1132-1143. doi:https://doi.org/10.1167/iovs.18-25210

Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum Open Access

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Sanne K. Verbakel; Ramon A. C. van Huet; Anneke I. den Hollander; Maartje J. Geerlings; Eveline Kersten; B. Jeroen Klevering; Caroline C. W. Klaver; Astrid S. Plomp; Nieneke L. Wesseling; Arthur A. B. Bergen; Konstantinos Nikopoulos; Carlo Rivolta; Yasuhiro Ikeda; Koh-Hei Sonoda; Yuko Wada; Camiel J. F. Boon; Toru Nakazawa; Carel B. Hoyng; Koji M. Nishiguchi

Tags: age-related macular degeneration, genes, macular dystrophy, mutation, retinitis pigmentosa

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1192-1203. doi:https://doi.org/10.1167/iovs.18-26084

Glaucoma

T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma Open Access

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Xiangjun Yang; Qun Zeng; Emre Göktaş; Kalashree Gopal; Lama Al-Aswad; Dana M. Blumberg; George A. Cioffi; Jeffrey M. Liebmann; Gülgün Tezel

Tags: glaucoma, t-lymphocyte subsets, t-lymphocytes

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 877-888. doi:https://doi.org/10.1167/iovs.18-26129

Comparison of Visual Field Progression Rates Among the High Tension Glaucoma, Primary Angle Closure Glaucoma, and Normal Tension Glaucoma Open Access

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Shonraj Ballae Ganeshrao; Sirisha Senthil; Nikhil Choudhari; Shravya Sri Durgam; Chandra Sekhar Garudadri

Tags: angle closure glaucoma, eye, glaucoma, low tension glaucoma, visual fields

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 889-900. doi:https://doi.org/10.1167/iovs.18-25421

Greater Severity of Glaucomatous Damage in Eyes With Than Without Choroidal Microvasculature Dropout in Open-Angle Glaucoma Open Access

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Youn Hye Jo; Junki Kwon; Kilhwan Shon; Daun Jeong; Michael S. Kook

Tags: eye, glaucoma, microvascular network, open-angle glaucoma

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 901-912. doi:https://doi.org/10.1167/iovs.18-26298

Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation Open Access

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Yanhui Ma; Elias Pavlatos; Keyton Clayson; Xueliang Pan; Sunny Kwok; Thomas Sandwisch; Jun Liu

Tags: body tissue, intraocular pressure, optic disk, ultrasonography, eye

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 913-920. doi:https://doi.org/10.1167/iovs.18-26071

Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma Open Access

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Diana C. Lozano; Tiffany E. Choe; William O. Cepurna; John C. Morrison; Elaine C. Johnson

Tags: glaucoma, optic disk, wounds and injuries, jak-stat signaling pathway

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 921-932. doi:https://doi.org/10.1167/iovs.18-25700

Hyperlipidemia, Blood Lipid Level, and the Risk of Glaucoma: A Meta-Analysis Open Access

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Shiming Wang; Xianyi Bao

Tags: glaucoma, hyperlipidemia, lipids, meta-analysis, intraocular pressure

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1028-1043. doi:https://doi.org/10.1167/iovs.18-25845

Sex-Specific Effect of BDNF Val66Met Genotypes on the Progression of Open-Angle Glaucoma Open Access

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Ting Shen; Vivek K. Gupta; Alexander Klistorner; Nitin Chitranshi; Stuart L. Graham; Yuyi You

Tags: brain-derived neurotrophic factor, genotype, glaucoma, open-angle glaucoma, val66met polymorphism

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1069-1075. doi:https://doi.org/10.1167/iovs.18-26364

Association of Gene Polymorphisms With Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis Open Access

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Min Chen; Xiaoning Yu; Jia Xu; Jian Ma; Xinyi Chen; Binbin Chen; Yuxiang Gu; Kaijun Wang

Tags: genes, meta-analysis, open-angle glaucoma, single nucleotide polymorphism, polymorphism

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1105-1121. doi:https://doi.org/10.1167/iovs.18-25922

Macula Vessel Density and Foveal Avascular Zone Parameters in Exfoliation Glaucoma Compared to Primary Open-Angle Glaucoma Open Access

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Shawn Philip; Ahmad Najafi; Apichat Tantraworasin; Toco Y. P. Chui; Richard B. Rosen; Robert Ritch

Tags: glaucoma, macula densa, macula lutea, open-angle glaucoma, peeling of skin

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1244-1253. doi:https://doi.org/10.1167/iovs.18-25986

Immunology and Microbiology

Impaired Autophagic Degradation of Transforming Growth Factor-β-Induced Protein by Macrophages in Lattice Corneal Dystrophy Open Access

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Ji Han; Ming Zhang; Hai-Yan Lin; Feng-Ying Huang; Ying-Ying Lin; Guang-Hong Tan; Zhen-You Zheng

Tags: autophagy, catabolism, hereditary corneal dystrophy, macrophages, proteins

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 978-989. doi:https://doi.org/10.1167/iovs.18-25838

Lens

Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0^ΔC/ΔC Mice Open Access

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Kulandaiappan Varadaraj; Sindhu Kumari

Tags: amino acids, cataract, lens (device), lens, crystalline, mice

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 858-867. doi:https://doi.org/10.1167/iovs.18-26378

Low Vision

Orientation Information in Encoding Facial Expressions for People With Central Vision Loss Open Access

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Deyue Yu; Susana T. L. Chung

Tags: blindness, face, facial expression, confusion

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1175-1184. doi:https://doi.org/10.1167/iovs.18-25380

Retina

Deep Learning Predicts OCT Measures of Diabetic Macular Thickening From Color Fundus Photographs Open Access

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Filippo Arcadu; Fethallah Benmansour; Andreas Maunz; John Michon; Zdenka Haskova; Dana McClintock; Anthony P. Adamis; Jeffrey R. Willis; Marco Prunotto

Tags: color, deep learning, diabetes mellitus, diabetic macular edema, fundus photography

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 852-857. doi:https://doi.org/10.1167/iovs.18-25634

Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy Open Access

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Tao Li; Yan Jia; Shanshan Wang; Anken Wang; Lu Gao; Chenhao Yang; Haidong Zou

Tags: child, diabetes mellitus, type 1, diabetic retinopathy, visual impairment, diabetes mellitus

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 990-998. doi:https://doi.org/10.1167/iovs.18-25499

Concentric Choriocapillaris Flow Deficits in Retinitis Pigmentosa Detected Using Wide-Angle Swept-Source Optical Coherence Tomography Angiography Open Access

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Manabu Miyata; Akio Oishi; Tomoko Hasegawa; Maho Oishi; Shogo Numa; Yuki Otsuka; Akihito Uji; Shin Kadomoto; Masayuki Hata; Hanako Ohashi Ikeda; Akitaka Tsujikawa

Tags: angiogram, fluid flow, optical coherence tomography, retinitis pigmentosa, face

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1044-1049. doi:https://doi.org/10.1167/iovs.18-26176

Reduced Vessel Density of the Choriocapillaris during Anti-Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration Open Access

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Taiichi Hikichi; Mitsuko Agarie

Tags: anti-vascular endothelial growth factor therapy, chief complaint, exudative age-related macular degeneration, eye, atrophy

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1088-1095. doi:https://doi.org/10.1167/iovs.18-24522

Three-Dimensional Adaptive Optics–Assisted Visualization of Photoreceptors in Healthy and Pathologically Aged Eyes Open Access

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Adrian Reumueller; Ursula Schmidt-Erfurth; Matthias Salas; Stefan Sacu; Wolfgang Drexler; Michael Pircher; Andreas Pollreisz

Tags: eye, face, optics, photoreceptors, drusen

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1144-1155. doi:https://doi.org/10.1167/iovs.18-25702

A Mouse Model of Retinal Recovery From Photo-Oxidative/Photo-Inflammatory Injury: Nrf2, SOD1, DJ-1, and Parkin Are Not Essential to Recovery Open Access

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Bo Chen; Bogale Aredo; Yuanfei Zhu; Yi Ding; Cynthia Xin-Zhao; Rafael L. Ufret-Vincenty

Tags: mice, oxidative stress, park2 gene, recovery of function, sod1 gene

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1165-1174. doi:https://doi.org/10.1167/iovs.18-25751

The Utah Protocol for Postmortem Eye Phenotyping and Molecular Biochemical Analysis Open Access

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Leah A. Owen; Akbar Shakoor; Denise J. Morgan; Andre A. Hejazi; M. Wade McEntire; Jared J. Brown; Lindsay A. Farrer; Ivana Kim; Albert Vitale; Margaret M. DeAngelis

Tags: autopsy, body tissue, donors, eye, phenotype determination

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1204-1212. doi:https://doi.org/10.1167/iovs.18-24254

Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients With Inherited Retinal Degenerations Open Access

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Katharina G. Foote; Irina De la Huerta; Kevin Gustafson; Angela Baldwin; Shiri Zayit-Soudry; Nicholas Rinella; Travis C. Porco; Austin Roorda; Jacque L. Duncan

Tags: retinal cone, retinal degeneration, spectral domain-optical coherence tomography

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1234-1243. doi:https://doi.org/10.1167/iovs.18-25688

Deletion of miR-182 Leads to Retinal Dysfunction in Mice Open Access

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Kun-Chao Wu; Xue-Jiao Chen; Guang-Hui Jin; Xiao-Yun Wang; Dan-Dan Yang; Yan-Ping Li; Lue Xiang; Bo-Wen Zhang; Gao-Hui Zhou; Chang-Jun Zhang; Zi-Bing Jin

Tags: mice, retina, pathophysiology, electroretinography

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1265-1274. doi:https://doi.org/10.1167/iovs.18-24166

Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy Open Access

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Dan Jiang; Renee C. Ryals; Samuel J. Huang; Kyle K. Weller; Hope E. Titus; Bryan M. Robb; Firas W. Saad; Ribal A. Salam; Hytham Hammad; Paul Yang; Daniel L. Marks; Mark E. Pennesi

Tags: fumarates, mice, microglia, retina, retinal degeneration

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1275-1285. doi:https://doi.org/10.1167/iovs.18-24398

Retinal Cell Biology

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury Open Access

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Wei Liu; Fan Xia; Yonju Ha; Shuang Zhu; Yi Li; Oluwarotimi Folorunso; Aryan Pashaei-Marandi; Pei-Yi Lin; Ronald G. Tilton; Anson P. Pierce; Hua Liu; Wenbo Zhang

Tags: heat-shock proteins 70, immunohistochemistry, ischemia, mice, neuroprotective effect

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 965-977. doi:https://doi.org/10.1167/iovs.18-26216

Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation Open Access

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Rupali Vohra; Blanca I. Aldana; Helle Waagepetersen; Linda H. Bergersen; Miriam Kolko

Tags: glucose, lactates, glutamate

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 999-1008. doi:https://doi.org/10.1167/iovs.18-25458

Visual Neuroscience

Impaired Spatial Hearing in Amblyopia: Evidence for Calibration of Auditory Maps by Retinocollicular Input in Humans Open Access

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Michael D. Richards; Herbert C. Goltz; Agnes M. F. Wong

Tags: amblyopia, calibration, hearing, sound localization, maps

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 944-953. doi:https://doi.org/10.1167/iovs.18-24908

Neural Responses of the Anterior Ventral Occipitotemporal Cortex in Developmental Dyslexia: Beyond the Visual Word Form Area Open Access

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Ana Pina Rodrigues; José Rebola; Marcelino Pereira; Marieke van Asselen; Miguel Castelo-Branco

Tags: dyslexia, reading disorder, developmental

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1063-1068. doi:https://doi.org/10.1167/iovs.18-26325

Visual Psychophysics and Physiological Optics

Regional Variations and Intra-/Intersession Repeatability for Scotopic Sensitivity in Normal Controls and Patients With Inherited Retinal Degenerations Open Access

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Lea D. Bennett; Georgiana Metz; Martin Klein; Kirsten G. Locke; Areeba Khwaja; David G. Birch

Tags: perimetry, retinal degeneration, nose, retina

Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1122-1131. doi:https://doi.org/10.1167/iovs.18-25473

Erratum

Erratum Open Access

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Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1009. doi:https://doi.org/10.1167/iovs.18-25786a

Erratum Open Access

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Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1224. doi:https://doi.org/10.1167/iovs.10-6187a

Erratum Open Access

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Investigative Ophthalmology & Visual Science March 2019, Vol.60, 1225. doi:https://doi.org/10.1167/iovs.17-23336a

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