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Anatomy and Pathology/Oncology

Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study Open Access
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Mathias Hvidtfelt Hansen; Xiao Qiang Li; Michael Larsen; Else Marie Olsen; Anne Mette Skovgaard; Line Kessel; Inger Christine Munch
Tags: eye, body height, choroid, refraction, follow-up
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3930-3936. doi:https://doi.org/10.1167/iovs.19-26807
Prevalence and Associations of Fundus Tessellation Among Junior Students From Greater Beijing Open Access
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Yin Guo; Lijuan Liu; Deqiang Zheng; Jiali Duan; Youxin Wang; Jost B. Jonas; Feifei Tian; Shuo Wang; Yujian Sang; Xiaoyu Zhang; Weijie Cao; Jinxia Zhang; Ming Sun; Qiuyue Tian; Xiaoni Meng; Xiuhua Guo; Lijuan Wu
Tags: adolescent, beijing, chinese (other dialects), chinese people, myopia
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4033-4040. doi:https://doi.org/10.1167/iovs.19-27382

Clinical and Epidemiologic Research

Effect of Anesthesia on Intraocular Pressure Measured With Continuous Wireless Telemetry in Nonhuman Primates Open Access
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Jessica V. Jasien; Christopher A. Girkin; J. Crawford Downs
Tags: intraocular pressure, primates, telemetry, wireless technology, ketamine
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3830-3834. doi:https://doi.org/10.1167/iovs.19-27758

Cornea

The Effect of Chloroquine on the Development of Dry Eye in Sjögren Syndrome Animal Model Open Access
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Hyun Jung Lee; Soojung Shin; Seul-Gi Yoon; Eun Jeong Cheon; So-Hyang Chung
Tags: animal model, chloroquine, dry eye syndromes, mice, sjogren's syndrome
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3708-3716. doi:https://doi.org/10.1167/iovs.19-27469
Effects of Amniotic Membrane–Derived Fibroblast Supernatant on Corneal Epithelium Open Access
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Kazunari Higa; Junko Higuchi; Reona Kimoto; Yoshiyuki Satake; Takefumi Yamaguchi; Daisuke Tomida; Jun Shimazaki
Tags: amnion, cornea, corneal epithelium, epithelium, fibroblasts
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3718-3726. doi:https://doi.org/10.1167/iovs.19-27041
Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye Open Access
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Mingli Qu; Xia Qi; Qian Wang; Lei Wan; Jing Li; Wei Li; Yingli Li; Qingjun Zhou
Tags: dry eye syndromes, mice, stat3 protein
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3776-3785. doi:https://doi.org/10.1167/iovs.19-26928
Relations Among Corneal Curvature, Thickness, and Volume in Keratoconus as Evaluated by Anterior Segment–Optical Coherence Tomography Open Access
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Naoyuki Morishige; Kazuyoshi Magome; Akifumi Ueno; Taka-Aki Matsui; Teruo Nishida
Tags: cicatrix, cornea, keratoconus, optical coherence tomography, volume
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3794-3802. doi:https://doi.org/10.1167/iovs.19-27619
The Role of the miR-21/SPRY2 Axis in Modulating Proangiogenic Factors, Epithelial Phenotypes, and Wound Healing in Corneal Epithelial Cells Open Access
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Yun Zhang; Fukang Yuan; Lin Liu; Zufeng Chen; Xiaoyun Ma; Zhen Lin; Jun Zou
Tags: corneal epithelial cells, epithelium, phenotype, wound healing, hypoxia
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3854-3862. doi:https://doi.org/10.1167/iovs.19-27013
Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy Open Access
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Ziye Rong; Jiaxin Hu; David R. Corey; V. Vinod Mootha
Tags: proteins, rna, cornea, body tissue
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3980-3991. doi:https://doi.org/10.1167/iovs.19-27641

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Abnormal Eye Position Signals in Interstitial Nucleus of Cajal in Monkeys With “A” Pattern Strabismus Open Access
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Adam Pallus; Michael Mustari; Mark M. G. Walton
Tags: cercopithecidae, eye, strabismus, interstitial nucleus of cajal, neurons
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3970-3979. doi:https://doi.org/10.1167/iovs.19-27490

Genetics

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus Open Access
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Ebony Liu; Georgia Kaidonis; Bennet J. McComish; Mark C. Gillies; Sotoodeh Abhary; Rohan W. Essex; John H. Chang; Bishwanath Pal; Mark Daniell; Stewart Lake; Nikolai Petrovsky; Alex W. Hewitt; Alicia Jenkins; Ecosse L. Lamoureux; Jonathan M. Gleadle; Jamie E. Craig; Kathryn P. Burdon
Tags: diabetes mellitus, type 1, diabetic retinopathy, genes, genetics, micrornas
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3937-3942. doi:https://doi.org/10.1167/iovs.18-25570
Pathway Analysis Integrating Genome-Wide and Functional Data Identifies PLCG2 as a Candidate Gene for Age-Related Macular Degeneration Open Access
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Andrea R. Waksmunski; Michelle Grunin; Tyler G. Kinzy; Robert P. Igo, Jr; Jonathan L. Haines; Jessica N. Cooke Bailey; for the International Age-Related Macular Degeneration Genomics Consortium
Tags: age-related macular degeneration, candidate disease gene, genes, genome, genome-wide association study
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4041-4051. doi:https://doi.org/10.1167/iovs.19-27827
Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients Open Access
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Xue-Bi Cai; Yi-Han Zheng; De-Fu Chen; Fang-Yue Zhou; Lu-Qi Xia; Xin-Ran Wen; Yi-Min Yuan; Fang Han; Shun-Yu Piao; Wenjuan Zhuang; Fan Lu; Jia Qu; A-Yong Yu; Zi-Bing Jin
Tags: chinese (other dialects), chinese people, genotype, myopia, phenotype
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4052-4062. doi:https://doi.org/10.1167/iovs.19-27921

Glaucoma

Peripapillary Choroidal Vascularity Index and Microstructure of Parapapillary Atrophy Open Access
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Min Hee Suh; Jun Woo Park; Neha Khandelwal; Rupesh Agrawal
Tags: atrophy, cortical blindness, antidepressive agents, tricyclic, trichloroacetic acid, spectral domain-optical coherence tomography
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3768-3775. doi:https://doi.org/10.1167/iovs.18-26286
Fixel-Based Analysis of Visual Pathway White Matter in Primary Open-Angle Glaucoma Open Access
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Shereif Haykal; Branislava Ćurčić-Blake; Nomdo M. Jansonius; Frans W. Cornelissen
Tags: glaucoma, open-angle glaucoma, visual pathways, white matter, otosclerosis
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3803-3812. doi:https://doi.org/10.1167/iovs.19-27447
Reversibility of Retinal Ganglion Cell Dysfunction From Chronic IOP Elevation Open Access
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Da Zhao; Vickie H. Y. Wong; Christine T. O. Nguyen; Andrew I. Jobling; Erica L. Fletcher; Algis J. Vingrys; Bang V. Bui
Tags: ganglia, intraocular pressure, pathophysiology, recovery of function, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3878-3886. doi:https://doi.org/10.1167/iovs.19-27113
Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner Open Access
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Mark S. Filla; Jennifer A. Faralli; Harini Desikan; Jennifer L. Peotter; Abigail C. Wannow; Donna M. Peters
Tags: fibril, fibronectins, integrins
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3897-3913. doi:https://doi.org/10.1167/iovs.19-27171
NOS3 Deletion in Cav1 Deficient Mice Decreases Drug Sensitivity to a Nitric Oxide Donor and Two Nitric Oxide Synthase Inhibitors Open Access
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Maomao Song; Liping Li; Yuan Lei; Xinghuai Sun
Tags: donors, intraocular pressure, mice, nitric oxide, nitric oxide synthase
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4002-4007. doi:https://doi.org/10.1167/iovs.19-27582

Immunology and Microbiology

S-layer Impacts the Virulence of Bacillus in Endophthalmitis Open Access
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Md Huzzatul Mursalin; Phillip S. Coburn; Erin Livingston; Frederick C. Miller; Roger Astley; Agnès Fouet; Michelle C. Callegan
Tags: bacillus, endophthalmitis, proteins, s-layer, speech-language pathology assistants
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3727-3739. doi:https://doi.org/10.1167/iovs.19-27453
CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection Open Access
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Steffani Fitzpatrick; Robert Lausch; Robert A. Barrington
Tags: cornea, human herpesvirus 1, infections, t-lymphocytes, mice
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3952-3962. doi:https://doi.org/10.1167/iovs.19-27810

Lens

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP Open Access
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Virginijus Valiunas; Peter R. Brink; Thomas W. White
Tags: cyclic amp, gap junction protein, lens (device), permeability, lens, crystalline
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3821-3829. doi:https://doi.org/10.1167/iovs.19-27302
Resveratrol Inhibits Wound Healing and Lens Fibrosis: A Putative Candidate for Posterior Capsule Opacification Prevention Open Access
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Andrew J. O. Smith; Julie A. Eldred; I. Michael Wormstone
Tags: lens, crystalline, resveratrol, wound healing, lens (device), after-cataract
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3863-3877. doi:https://doi.org/10.1167/iovs.18-26248
Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation Open Access
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Bharat Kumar; Heather L. Chandler; Timothy Plageman; Matthew A. Reilly
Tags: lens (device), lens, crystalline, stretching exercises
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3920-3929. doi:https://doi.org/10.1167/iovs.19-26893
Connexin 50 and AQP0 are Essential in Maintaining Organization and Integrity of Lens Fibers Open Access
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Sumin Gu; Sondip Biswas; Luis Rodriguez; Zhen Li; Yuting Li; Manuel A. Riquelme; Wen Shi; Ke Wang; Thomas W. White; Matthew Reilly; Woo-Kuen Lo; Jean X. Jiang
Tags: lens (device), lens, crystalline, gap junction protein, mice, personal integrity
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4021-4032. doi:https://doi.org/10.1167/iovs.18-26270

Low Vision

Binocular Inhibition of Reading in Macular Telangiectasia Type 2 Open Access
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Simone Tzaridis; Philipp Herrmann; Peter Charbel Issa; Simona Degli Esposti; Siegfried K Wagner; Marcus Fruttiger; Catherine Egan; Gary Rubin; Frank G. Holz; Tjebo F. C. Heeren
Tags: eye, reading (activity), reading speed, scotoma, telangiectasis
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3835-3841. doi:https://doi.org/10.1167/iovs.18-26414

Physiology and Pharmacology

Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms Open Access
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Norihiro Nagai; Masahiko Ayaki; Tatsuo Yanagawa; Atsuhiko Hattori; Kazuno Negishi; Takuro Mori; Takahiro J. Nakamura; Kazuo Tsubota
Tags: blue light, circadian rhythms, night time, sleep quality, irs2 protein, human
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3786-3793. doi:https://doi.org/10.1167/iovs.19-27195
In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots Open Access
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Munetoyo Toda; Hiroshi Yukawa; Jun Yamada; Morio Ueno; Shigeru Kinoshita; Yoshinobu Baba; Junji Hamuro
Tags: anterior chamber of eye, cornea, endothelial cells, eye, fluorescence
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4008-4020. doi:https://doi.org/10.1167/iovs.19-27788

Retina

Patterns and Intensities of Near-Infrared and Short-Wavelength Fundus Autofluorescence in Choroideremia Probands and Carriers Open Access
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Maarjaliis Paavo; Jose R. L. Carvalho, Jr; Winston Lee; Jesse D. Sengillo; Stephen H. Tsang; Janet R. Sparrow
Tags: choroideremia, eye, fundus autofluorescence imaging, multimodal imaging, proband
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3752-3761. doi:https://doi.org/10.1167/iovs.19-27366
The Oxygen Saturation in Vascular Abnormalities Depends on the Extent of Arteriovenous Shunting in Diabetic Retinopathy Open Access
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Line Petersen; Toke Bek
Tags: diabetic retinopathy, oxygen saturation measurement, vascular diseases, venule
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3762-3767. doi:https://doi.org/10.1167/iovs.19-27472
Immune and Inflammatory Proteins in Cord Blood as Predictive Biomarkers of Retinopathy of Prematurity in Preterm Infants Open Access
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Young Joo Park; Se Joon Woo; Yu Mi Kim; Subeen Hong; Young Eun Lee; Kyo Hoon Park
Tags: biological markers, infant, premature, plasma, proteins, retinopathy of prematurity
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3813-3820. doi:https://doi.org/10.1167/iovs.19-27258
δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes Open Access
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Jacqueline M. Lopes de Faria; Diego A. Duarte; Rafael Simó; Marta García-Ramirez; Marcella N. Dátilo; Francieli C. Pasqualetto; José B. Lopes de Faria
Tags: agonists, diabetes mellitus, diabetes mellitus, type 2, opioid receptor, retina
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3842-3853. doi:https://doi.org/10.1167/iovs.19-26761
A Pilot Optical Coherence Tomography Angiography Study on Superficial and Deep Capillary Plexus Foveal Avascular Zone in Patients With Beta-Thalassemia Major Open Access
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Ilias Georgalas; Georgios Makris; Dimitrios Papaconstantinou; Petros Petrou; Evangelia Chalkiadaki; Konstantinos Droutsas; Konstantinos Andreanos; Menelaos Kanakis
Tags: angiogram, blood capillaries, cooley's anemia, diameter, iron
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3887-3896. doi:https://doi.org/10.1167/iovs.19-27291
Longitudinal Changes in the Peripapillary Retinal Nerve Fiber Layer Thickness in Hypertension: 4-Year Prospective Observational Study Open Access
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Min-Woo Lee; Woo-Hyuk Lee; Gi-Seok Park; Hyung-Bin Lim; Jung-Yeul Kim
Tags: hypertension, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3914-3919. doi:https://doi.org/10.1167/iovs.19-27652
Light Sensitivity Within Areas of Geographic Atrophy Secondary to Age-Related Macular Degeneration Open Access
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Maximilian Pfau; Leon von der Emde; Chantal Dysli; Sarah Thiele; Philipp T. Möller; Moritz Lindner; Jennifer Nadal; Matthias Schmid; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein
Tags: age-related macular degeneration, atrophy, photophobia, false-positive results, perimetry
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3992-4001. doi:https://doi.org/10.1167/iovs.19-27178

Retinal Cell Biology

Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma Open Access
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Sari Honda; Kazuhiko Namekata; Atsuko Kimura; Xiaoli Guo; Chikako Harada; Akira Murakami; Akira Matsuda; Takayuki Harada
Tags: glaucoma, low tension glaucoma, melanopsin, mice, neurotoxicity syndromes
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3696-3707. doi:https://doi.org/10.1167/iovs.19-27145
Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging Open Access
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Yuanfei Zhu; Bogale Aredo; Bo Chen; Cynthia X. Zhao; Yu-Guang He; Rafael L. Ufret-Vincenty
Tags: aging, mice, parkinson disease 7, autosomal recessive early-onset, retinal degeneration, park2 gene
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3740-3751. doi:https://doi.org/10.1167/iovs.19-27212
Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy Open Access
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Ghulam Mohammad; Rakesh Radhakrishnan; Renu A. Kowluru
Tags: diabetes mellitus, diabetic retinopathy, dna (cytosine-5-)-methyltransferase 1, dna, mitochondrial, epigenetics
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3943-3951. doi:https://doi.org/10.1167/iovs.19-27602

Visual Neuroscience

The Detection Of Misrouting In Albinism: Evaluation of Different VEP Procedures in a Heterogeneous Cohort Open Access
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Charlotte C. Kruijt; Gerard C. de Wit; Herman E. Talsma; Nicoline E. Schalij-Delfos; Maria M. van Genderen
Tags: albinism, cohort studies, evoked potentials, visual, heterogeneity
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3963-3969. doi:https://doi.org/10.1167/iovs.19-27364
Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells Open Access
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Johnnie M. Moore-Dotson; Erika D. Eggers
Tags: amacrine cells, diabetes mellitus, gamma-aminobutyric acid, retinal bipolar cells, rod photoreceptors
Investigative Ophthalmology & Visual Science September 2019, Vol.60, 4063-4073. doi:https://doi.org/10.1167/iovs.19-27137

Erratum

Erratum Open Access
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Investigative Ophthalmology & Visual Science September 2019, Vol.60, 3717. doi:https://doi.org/10.1167/iovs.18-25999a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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