Volume 61 Issue 5 | IOVS

Lower Levels of Adiponectin and Its Receptor Adipor1 in the Uveal Melanomas With Monosomy-3 Open Access

Aysegül Tura; Christiane Thieme; Anton Brosig; Hartmut Merz; Mahdy Ranjbar; Siranush Vardanyan; Huaxin Zuo; Tjorge Maassen; Vinodh Kakkassery; Salvatore Grisanti

Tags: adiponectin, neoplasms, proteins

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 12. doi:https://doi.org/10.1167/iovs.61.5.12

Visual Image Quality Impacts Circadian Rhythm-Related Gene Expression in Retina and in Choroid: A Potential Mechanism for Ametropias Open Access

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Richard A. Stone; Wenjie Wei; Shanta Sarfare; Brendan McGeehan; K. Cameron Engelhart; Tejvir S. Khurana; Maureen G. Maguire; P. Michael Iuvone; Debora L. Nickla

Tags: choroid, circadian clocks, eye, gene expression, genes

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 13. doi:https://doi.org/10.1167/iovs.61.5.13

Biochemistry and Molecular Biology

Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase Open Access

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Verena Schmid; Karolina Plössl; Carina Schmid; Sarah Bernklau; Bernhard H. F. Weber; Ulrike Friedrich

Tags: adenosine triphosphatases, cardiac glycosides, ouabain, digoxin

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 1. doi:https://doi.org/10.1167/iovs.61.5.1

The Appearance of the Warburg Effect in the Developing Avian Eye Characterized In Ovo: How Neurogenesis Can Remodel Neuroenergetics Open Access

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Antoine Cherix; Laurent Brodier; Carole Poitry-Yamate; Jean-Marc Matter; Rolf Gruetter

Tags: aves, citrates, eye, lactates, mitochondria

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 3. doi:https://doi.org/10.1167/iovs.61.5.3

microRNA -378a-3p Restrains the Proliferation of Retinoblastoma Cells but Promotes Apoptosis of Retinoblastoma Cells via Inhibition of FOXG1 Open Access

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Chao Zhang; Shuai Wu

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 31. doi:https://doi.org/10.1167/iovs.61.5.31

KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells Open Access

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Yuki Kanzaki; Hirofumi Fujita; Keita Sato; Mio Hosokawa; Hiroshi Matsumae; Fumio Shiraga; Yuki Morizane; Hideyo Ohuchi

Tags: gene deletion, phagocytosis, pluripotent stem cells, retinal pigment epithelium, genes

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 38. doi:https://doi.org/10.1167/iovs.61.5.38

Genes Involved in Energy Metabolism Are Differentially Expressed During the Day–Night Cycle in Murine Retinal Pigment Epithelium Open Access

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Elja M. M. Louer; Guoqiang Yi; Claudia Carmone; Joris Robben; Henk G. Stunnenberg; Anneke I. den Hollander; Peter M. T. Deen

Tags: genes, mice, rhythm, metabolism, retinal pigment epithelium

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 49. doi:https://doi.org/10.1167/iovs.61.5.49

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects Open Access

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Haoyu Li; Chao Ma; Wei Liu; Jianfeng He; Kaijun Li

Tags: fibroblasts, fibrosis, graves' ophthalmopathy, inflammation

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 64. doi:https://doi.org/10.1167/iovs.61.5.64

Clinical and Epidemiologic Research

Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank Open Access

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Sharon Y. L. Chua; Anthony P. Khawaja; Andrew D. Dick; James Morgan; Baljean Dhillon; Andrew J. Lotery; Nicholas G. Strouthidis; Charles Reisman; Tunde Peto; Peng T. Khaw; Paul J. Foster; Praveen J. Patel; on behalf of The UK Biobank Eye and Vision Consortium

Tags: air pollution, biobanks, language morphology, morphology

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 32. doi:https://doi.org/10.1167/iovs.61.5.32

Association of Age-Related Cataract With Skin Cancer in an Australian Population Open Access

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Shiwani Sharma; Catherine Lang; Jyoti Khadka; Maria C. Inacio

Tags: cataract, cataract, senile, skin cancer, medical history

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 48. doi:https://doi.org/10.1167/iovs.61.5.48

Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications Open Access

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Huijing Ye; Wei Xiao; Rongxin Chen; Ping Zhang; Lijuan Tang; Jingqiao Chen; Te Zhang; Xian Ji; Lu Shi; Huasheng Yang

Tags: immunoglobulin g4, graves' ophthalmopathy

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 57. doi:https://doi.org/10.1167/iovs.61.5.57

Cornea

Agrin Promotes Limbal Stem Cell Proliferation and Corneal Wound Healing Through Hippo-Yap Signaling Pathway Open Access

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Lulu Hou; Wenbin Fu; Ying Liu; Qun Wang; Liqiang Wang; Yifei Huang

Tags: agrin, cornea, stem cells, wound healing, signal pathway

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 7. doi:https://doi.org/10.1167/iovs.61.5.7

KLF4 Coordinates Corneal Epithelial Apical-Basal Polarity and Plane of Cell Division and Is Downregulated in Ocular Surface Squamous Neoplasia Open Access

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Anil Tiwari; Sudha Swamynathan; Vishal Jhanji; Shivalingappa K. Swamynathan

Tags: cell growth, cornea, epithelium, ocular surface squamous neoplasia, polarity

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 15. doi:https://doi.org/10.1167/iovs.61.5.15

ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas Open Access

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Nan Gao; Rao Me; Chenyang Dai; Fu-shin X. Yu

Tags: bacterial keratitis, cornea, immune response, infections, interferons

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 26. doi:https://doi.org/10.1167/iovs.61.5.26

Theoretical Analysis of Wave-Front Aberrations Induced from Conventional Laser Refractive Surgery in a Biomechanical Finite Element Model Open Access

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Lihua Fang; Weiwei Ma; Yan Wang; Yu Dai; Zhaohui Fang

Tags: cornea, surgical ocular refractive procedure, lasers, intraocular pressure

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 34. doi:https://doi.org/10.1167/iovs.61.5.34

The Differential Expression of Cytokines and Growth Factors After SMILE Compared With FS-LASIK in Rabbits Open Access

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Lingjia Liu; Wenbo Cheng; Di Wu; Luxia Chen; Shasha Yu; Tong Zuo; Lin Zhang; Kun Yang; Hua Li; Hui Zhang; Pinghui Wei; Alex Lap Ki Ng; George Pak-Man Cheng; Victor Chi-Pang Woo; Jia Yin; Kin Chiu; Yan Wang

Tags: cornea, cytokine, growth factor, keratomileusis, laser in situ, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 55. doi:https://doi.org/10.1167/iovs.61.5.55

Collagen XII Is a Regulator of Corneal Stroma Structure and Function Open Access

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Mei Sun; Nabeel Zafrullah; Floriane Devaux; Chinda Hemmavanh; Sheila Adams; Noel M. Ziebarth; Manuel Koch; David E. Birk; Edgar M. Espana

Tags: collagen, cornea, corneal stroma, fibril

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 61. doi:https://doi.org/10.1167/iovs.61.5.61

HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling Open Access

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Ying-Ting Zhu; Fu Li; Yuan Zhang; Szu-Yu Chen; Sean Tighe; Shin-Ying Lin; Scheffer C. G. Tseng

Tags: cornea, fibroblasts, keratocytes, myofibroblasts, ptx3 protein

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 62. doi:https://doi.org/10.1167/iovs.61.5.62

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Visual and Vestibular Integration Express Summative Eye Movement Responses and Reveal Higher Visual Acceleration Sensitivity than Previously Described Open Access

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Tobias Wibble; Johanna Engström; Tony Pansell

Tags: eye movement, musculoskeletal torsion, function, torsion, photic stimulation

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 4. doi:https://doi.org/10.1167/iovs.61.5.4

Effect of Stimulus Orientation on Visual Function in Children with Refractive Amblyopia Open Access

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Tiong Peng Yap; Chi D. Luu; Catherine Suttle; Audrey Chia; Mei Ying Boon

Tags: amblyopia, anisotropy, astigmatism, child, evoked potentials, visual

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 5. doi:https://doi.org/10.1167/iovs.61.5.5

Abnormal Tuning in Nucleus Prepositus Hypoglossi of Monkeys With “A” Pattern Exotropia Open Access

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Adam Pallus; Mark M. G. Walton

Tags: cercopithecidae, exotropia, eye, neurons, strabismus

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 45. doi:https://doi.org/10.1167/iovs.61.5.45

Orbital Fat Volume After Treatment with Topical Prostaglandin Agonists Open Access

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Jessica Y. Chen; Alan Le; Joseph Caprioli; JoAnn A. Giaconi; Kouros Nouri-Mahdavi; Simon K. Law; Laura Bonelli; Anne L. Coleman; Joseph L. Demer

Tags: agonists, magnetic resonance imaging, open-angle glaucoma, orbit, orbital fat

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 46. doi:https://doi.org/10.1167/iovs.61.5.46

Genetics

FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome Open Access

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Lei Jiang; Yulei Li; Kangjuan Yang; Yuping Wang; Jiuxiang Wang; Xiaoniu Cui; Jinglin Mao; Yong Gao; Ping Yi; Lejin Wang; Jing Yu Liu

Tags: gabra2 gene, mutation, pathologic nystagmus, syndrome, proteins

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 41. doi:https://doi.org/10.1167/iovs.61.5.41

Glaucoma

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch Open Access

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Hannah Youngblood; Jingwen Cai; Michelle D. Drewry; Inas Helwa; Eric Hu; Sabrina Liu; Hongfang Yu; Hongmei Mu; Yanzhong Hu; Kristin Perkumas; Inas F. Aboobakar; William M. Johnson; W. Daniel Stamer; Yutao Liu

Tags: micrornas, rna, messenger, genes

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 2. doi:https://doi.org/10.1167/iovs.61.5.2

Time-Dependent Effects of Reduced Cerebrospinal Fluid Pressure on Optic Nerve Retrograde Axonal Transport Open Access

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Zheng Zhang; Shen Wu; Kegao Liu; Jingxue Zhang; Qian Liu; Lei Li; Ningli Wang

Tags: axon, axonal transport, cerebrospinal fluid pressure, optic nerve, fluoro-gold

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 6. doi:https://doi.org/10.1167/iovs.61.5.6

Comparison of Lamina Cribrosa Morphology in Normal Tension Glaucoma and Autosomal-Dominant Optic Atrophy Open Access

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Gyu-Nam Kim; Ji-Ah Kim; Mi-Ji Kim; Eun Ji Lee; Jeong-Min Hwang; Tae-Woo Kim

Tags: cribriform plate, eye, language morphology, low tension glaucoma, morphology

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 9. doi:https://doi.org/10.1167/iovs.61.5.9

Age and Menopause Effects on Ocular Compliance and Aqueous Outflow Open Access

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Andrew J. Feola; Joseph M. Sherwood; Machelle T. Pardue; Darryl R. Overby; C. Ross Ethier

Tags: glaucoma, menopause

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 16. doi:https://doi.org/10.1167/iovs.61.5.16

Statins Suppress TGF-β2-Mediated MMP-2 and MMP-9 Expression and Activation Through RhoA/ROCK Inhibition in Astrocytes of the Human Optic Nerve Head Open Access

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Mi-Lyang Kim; Kyung Rim Sung; Junki Kwon; Jin A. Shin

Tags: astrocytes, gelatinase a, gelatinase b, optic disk, rhoa gtp-binding protein

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 29. doi:https://doi.org/10.1167/iovs.61.5.29

ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway Open Access

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Chunchun Hu; Liangliang Niu; Liping Li; Maomao Song; Youjia Zhang; Yuan Lei; Yuhong Chen; Xinghuai Sun

Tags: abca1 gene, intraocular pressure, nitric oxide synthase, open-angle glaucoma, signal pathway

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 33. doi:https://doi.org/10.1167/iovs.61.5.33

Morphologic Features of Crystalline Lens in Patients with Primary Angle Closure Disease Observed by CASIA 2 Optical Coherence Tomography Open Access

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Xiaolei Wang; Xiaoxiao Chen; Yizhen Tang; Jiajian Wang; Yuhong Chen; Xinghuai Sun

Tags: lens, crystalline, optical coherence tomography, phased thoracic-abdominal compression-decompression, lens (device), eye

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 40. doi:https://doi.org/10.1167/iovs.61.5.40

Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma Open Access

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Ralph J. Hazlewood; John Kuchtey; Hang-Jing Wu; Rachel W. Kuchtey

Tags: axon, glaucoma, mice, neuroprotective effect, telmisartan

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 51. doi:https://doi.org/10.1167/iovs.61.5.51

Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis Open Access

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Won June Lee; Ki Ho Park; Mincheol Seong

Tags: emotional vulnerability, glaucoma, optical coherence tomography, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 56. doi:https://doi.org/10.1167/iovs.61.5.56

Immediate Impact of Acute Elevation of Intraocular Pressure on Cortical Visual Motion Processing Open Access

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Nini Yuan; Mengwei Li; Xiaoxiao Chen; Yiliang Lu; Yuan Fang; Hongliang Gong; Liling Qian; Jihong Wu; Shenghai Zhang; Stewart Shipp; Ian Max Andolina; Xinghuai Sun; Wei Wang

Tags: intraocular pressure, motion

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 59. doi:https://doi.org/10.1167/iovs.61.5.59

Immunology and Microbiology

Inflammatory and Angiogenic Mediators in Amniotic Fluid Are Associated With the Development of Retinopathy of Prematurity in Preterm Infants Open Access

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Se Joon Woo; Jun Young Park; Subeen Hong; Yu Mi Kim; Ye Hyon Park; Young Eun Lee; Kyo Hoon Park

Tags: amniotic fluid, angiogenesis, infant, premature, proteins, retinopathy of prematurity

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 42. doi:https://doi.org/10.1167/iovs.61.5.42

Low Vision

Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration Open Access

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Sandrine H. Künzel; Philipp T. Möller; Moritz Lindner; Lukas Goerdt; Jennifer Nadal; Matthias Schmid; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein; Maximilian Pfau

Tags: age-related macular degeneration, atrophy, eye, quality of life, vision

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 63. doi:https://doi.org/10.1167/iovs.61.5.63

Physiology and Pharmacology

Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium Open Access

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Jingshu Liu; Rachel L. Taylor; Richard A. Baines; Lisa Swanton; Sally Freeman; Barbara Corneo; Achchhe Patel; Alan Marmorstein; Travis Knudsen; Graeme C. Black; Forbes Manson

Tags: best1 gene, molecule, bestrophinopathy, small molecule, retinal pigment epithelium

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 28. doi:https://doi.org/10.1167/iovs.61.5.28

Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes Open Access

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Travis W. Hein; Tsuneaki Omae; Wenjuan Xu; Akitoshi Yoshida; Lih Kuo

Tags: arginase, arteriole, diabetes mellitus, dilatation, pathologic, endothelium

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 36. doi:https://doi.org/10.1167/iovs.61.5.36

Polarized Expression of Ion Channels and Solute Carrier Family Transporters on Heterogeneous Cultured Human Corneal Endothelial Cells Open Access

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Junji Hamuro; Hideto Deguchi; Tomoko Fujita; Koji Ueda; Yuichi Tokuda; Nao Hiramoto; Kohsaku Numa; Masakazu Nakano; John Bush; Morio Ueno; Chie Sotozono; Shigeru Kinoshita

Tags: cornea, endothelial cells, family, heterogeneity, ion channels

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 47. doi:https://doi.org/10.1167/iovs.61.5.47

Retina

Macular Functional and Morphological Changes in Intermediate Age-Related Maculopathy Open Access

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Vincenzo Parisi; Lucia Ziccardi; Eliana Costanzo; Massimiliano Tedeschi; Lucilla Barbano; Daniela Manca; Antonio Di Renzo; Paola Giorno; Monica Varano; Mariacristina Parravano

Tags: age-related macular degeneration, eye, parafoveal region, spectral domain-optical coherence tomography, chief complaint

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 11. doi:https://doi.org/10.1167/iovs.61.5.11

PAX6 Genotypic and Retinal Phenotypic Characterization in Congenital Aniridia Open Access

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Hilde R. Pedersen; Rigmor C. Baraas; Erlend C. S. Landsend; Øygunn A. Utheim; Tor P. Utheim; Stuart J. Gilson; Maureen Neitz

Tags: aniridia, genotype, pax6 transcription factor, phenotype, mutation

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 14. doi:https://doi.org/10.1167/iovs.61.5.14

Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size Open Access

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Bénédicte M. J. Merle; Bernard Rosner; Johanna M. Seddon

Tags: diet, drusen, genetic predisposition to disease, genetics

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 17. doi:https://doi.org/10.1167/iovs.61.5.17

Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy Open Access

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Sun Young Lee; John W. Surbeck; Michael Drake; Apryl Saunders; Haoxing D. Jin; Vinay A. Shah; Raju V. Rajala

Tags: biological markers, glial fibrillary acidic protein, retinal detachment, vimentin, vitreoretinopathy, proliferative

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 22. doi:https://doi.org/10.1167/iovs.61.5.22

Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome Open Access

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Daniella B. Victorino; Jonah J. Scott-McKean; Mark W. Johnson; Alberto C. S. Costa

Tags: mice, retina, electroretinography, down syndrome

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 25. doi:https://doi.org/10.1167/iovs.61.5.25

Differences in Blood Flow Between Superior and Inferior Retinal Hemispheres Open Access

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Ryo Tomita; Takeshi Iwase; Yoshitaka Ueno; Kensuke Goto; Kentaro Yamamoto; Eimei Ra; Hiroko Terasaki

Tags: retina, vascular flow

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 27. doi:https://doi.org/10.1167/iovs.61.5.27

Treatment Potential for LCA5-Associated Leber Congenital Amaurosis Open Access

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Katherine E. Uyhazi; Puya Aravand; Brent A. Bell; Zhangyong Wei; Lanfranco Leo; Leona W. Serrano; Denise J. Pearson; Ivan Shpylchak; Jennifer Pham; Vidyullatha Vasireddy; Jean Bennett; Tomas S. Aleman

Tags: electroretinography, leber's amaurosis, mice, photoreceptors, tissue degeneration

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 30. doi:https://doi.org/10.1167/iovs.61.5.30

Identifying Microvascular and Neural Parameters Related to the Severity of Diabetic Retinopathy Using Optical Coherence Tomography Angiography Open Access

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Xiaoli Li; Jie Xie; Liang Zhang; Ying Cui; Guanrong Zhang; Xiangting Chen; Jun Wang; Aiping Zhang; Tian Huang; Qianli Meng

Tags: angiogram, diabetic retinopathy, optical coherence tomography, eye, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 39. doi:https://doi.org/10.1167/iovs.61.5.39

Segmented Macular Layer Volumes from Spectral Domain Optical Coherence Tomography in 184 Adult Twins: Associations With Age and Heritability Open Access

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Ali Lamin; Zakariya Jarrar; Katie M. Williams; Anurag Garg; Khadijah Basheer; Sobha Sivaprasad; Christopher J. Hammond; Omar A. Mahroo

Tags: adult, cohort studies, spectral domain-optical coherence tomography, twins, volume

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 44. doi:https://doi.org/10.1167/iovs.61.5.44

Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment Open Access

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Bing X. Ross; Joanne Choi; Jingyu Yao; Heather M. Hager; Steven F. Abcouwer; David N. Zacks

Tags: hmgb1 protein, retinal detachment, rod photoreceptors, proteins, tissue degeneration

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 50. doi:https://doi.org/10.1167/iovs.61.5.50

Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion Open Access

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Adrian Au; Assaf Hilely; Jackson Scharf; Frederic Gunnemann; Derrick Wang; Ismael Chehaibou; Claudio Iovino; Christelle Grondin; Marie-Louise Farecki; Khalil Ghasemi Falavarjani; Nopasak Phasukkijwatana; Marco Battista; Enrico Borrelli; Riccardo Sacconi; Brittany Powell; Grant Hom; Tyler E. Greenlee; Thais F. Conti; Gerardo Ledesma-Gil; Mehmet Yasin Teke; Netan Choudhry; Adrian T. Fung; Valerie Krivosic; Jiwon Baek; Mee Yon Lee; Yoshimi Sugiura; Giuseppe Querques; Enrico Peiretti; Richard Rosen; Won Ki Lee; Lawrence A. Yannuzzi; Dinah Zur; Anat Loewenstein; Daniel Pauleikhoff; Rishi Singh; Yasha Modi; Jean Pierre Hubschman; Michael Ip; SriniVas Sadda; K. Bailey Freund; David Sarraf

Tags: hemorrhage, central retinal vein occlusion, nerve fibers, ischemia, retinal hemorrhage

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 54. doi:https://doi.org/10.1167/iovs.61.5.54

Evaluating Signs of Microangiopathy Secondary to Diabetes in Different Areas of the Retina with Swept Source OCTA Open Access

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Sonja G. Karst; Morgan Heisler; Julian Lo; Nathan Schuck; Abdollah Safari; Marinko V. Sarunic; David A. L. Maberley; Eduardo V. Navajas

Tags: diabetes mellitus, diabetes mellitus, type 2, perfusion, retina, blood capillaries

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 8. doi:https://doi.org/10.1167/iovs.61.5.8

Retinal Cell Biology

Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity in the Mouse Retinal Pigment Epithelium Open Access

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Varunika Goyal; Christopher DeVera; Virginie Laurent; Jana Sellers; Micah A. Chrenek; David Hicks; Kenkichi Baba; P. Michael Iuvone; Gianluca Tosini

Tags: dopamine, mice, signal transduction, phagocytosis, retinal pigment epithelium

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 10. doi:https://doi.org/10.1167/iovs.61.5.10

Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B Open Access

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Camilla Pilotti; John Greenwood; Stephen E. Moss

Tags: angiogenesis, complement factor b, metatarsal bone, proteins

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 19. doi:https://doi.org/10.1167/iovs.61.5.19

Autofluorescent Granules of the Human Retinal Pigment Epithelium: Phenotypes, Intracellular Distribution, and Age-Related Topography Open Access

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Katharina Bermond; Christina Wobbe; Ioana-Sandra Tarau; Rainer Heintzmann; Jost Hillenkamp; Christine A. Curcio; Kenneth R. Sloan; Thomas Ach

Tags: granules, retinal pigment cell

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 35. doi:https://doi.org/10.1167/iovs.61.5.35

Voluntary Exercise Suppresses Choroidal Neovascularization in Mice Open Access

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Ryan D. Makin; Dionne Argyle; Shuichiro Hirahara; Yosuke Nagasaka; Mei Zhang; Zhen Yan; Nagaraj Kerur; Jayakrishna Ambati; Bradley D. Gelfand

Tags: choroidal neovascularization, exercise, mice

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 52. doi:https://doi.org/10.1167/iovs.61.5.52

Visual Neuroscience

ERG Responses in Mice with Deletion of the Synaptic Ribbon Component RIBEYE Open Access

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Richard Fairless; Sarah K. Williams; Rashmi Katiyar; Stephan Maxeiner; Frank Schmitz; Ricarda Diem

Tags: electroretinography, mice, mice, knockout, synapses

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 37. doi:https://doi.org/10.1167/iovs.61.5.37

Useful Field of View Performance in the Intact Visual Field of Hemianopia Patients Open Access

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Karlijn Woutersen; Anna C. Geuzebroek; Albert V. van den Berg; Jeroen Goossens

Tags: hemianopsia, visual fields, scotoma, visual field defects

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 43. doi:https://doi.org/10.1167/iovs.61.5.43

Visual Psychophysics and Physiological Optics

Grouping Effects on Foveal Spatial Interactions in Children Open Access

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Sarah J. Waugh; Monika A. Formankiewicz

Tags: adult, child, visual acuity

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 23. doi:https://doi.org/10.1167/iovs.61.5.23

Experimental Model of Far Temporal Field Negative Dysphotopsia Generated in Phakic Eyes Open Access

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Viswanathan Ramasubramanian; Dawn Meyer; Pete S. Kollbaum; Arthur Bradley

Tags: contact lenses, eye, nose, retina, pupil

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 24. doi:https://doi.org/10.1167/iovs.61.5.24

Implied Motion From Form Shows Motion Aids the Perception of Global Form in Amblyopia Open Access

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Mahesh R. Joshi; Anita J. Simmers; Seong T. Jeon

Tags: amblyopia, motion, perception, noise, glass

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 58. doi:https://doi.org/10.1167/iovs.61.5.58

The Temporal Window of Visual Processing in Aging Open Access

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Xianghang He; Menglu Shen; Rong Cui; Haiyan Zheng; Xiaowei Ruan; Zhong-Lin Lu; Fang Hou

Tags: aging, noise, perceptual masking, vision, visual processing

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 60. doi:https://doi.org/10.1167/iovs.61.5.60

Clinical Trials

Defocus Incorporated Multiple Segments Spectacle Lenses Changed the Relative Peripheral Refraction: A 2-Year Randomized Clinical Trial Open Access

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Han Yu Zhang; Carly Siu Yin Lam; Wing Chun Tang; Myra Leung; Chi Ho To

Tags: clinical trials, lens (device), lens, crystalline, refraction, myopia

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 53. doi:https://doi.org/10.1167/iovs.61.5.53

Letters to the Editor

Mouse Meibomian Gland Dysfunction Model Open Access

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Jingyi Wang; Yang Liu; Wendy R. Kam; David A. Sullivan

Tags: meibomian gland dysfunction, mice

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 18. doi:https://doi.org/10.1167/iovs.61.5.18

Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection? Open Access

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Antonello Caruso; Norman A. Mazer

Tags: half-life, intravitreal injections

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 20. doi:https://doi.org/10.1167/iovs.61.5.20

Author Response: Does the Fc Region Have a Role in the Ocular Half-Life After Intravitreal Injection? Open Access

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Kwangsic Joo; Yewon Choi; Jae-Yong Chung; Se Joon Woo

Tags: half-life, intravitreal injections

Investigative Ophthalmology & Visual Science May 2020, Vol.61, 21. doi:https://doi.org/10.1167/iovs.61.5.21

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