Volume 61 Issue 6 | IOVS

Editorial

New Section on Using Data from Vision Research Free

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Maureen G. Maguire

Tags: vision research

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 26. doi:https://doi.org/10.1167/iovs.61.6.26

Focus on Data

Display of Data Free

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Johannes Ledolter; Oliver W. Gramlich; Randy H. Kardon

Tags: data display, graphical displays

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 25. doi:https://doi.org/10.1167/iovs.61.6.25

Assessing Intereye Symmetry and Its Implications for Study Design Free

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Maureen G. Maguire

Tags: eye, research design

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 27. doi:https://doi.org/10.1167/iovs.61.6.27

Anatomy and Pathology/Oncology

Transient Expression of Lymphatic Markers in Retrobulbar Intraconal Orbital Vasculature During Fetal Development Free

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Quincy C. C. van den Bosch; Jackelien G. M. van Beek; Emine Kiliç; Robert M. Verdijk

Tags: fetal development, lymphatic vessels, vasculature, immunohistochemistry

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 22. doi:https://doi.org/10.1167/iovs.61.6.22

Biochemistry and Molecular Biology

Elimination of a Retinal Riboflavin Binding Protein Exacerbates Degeneration in a Model of Cone-Rod Dystrophy Free

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Ayse M. Genc; Mustafa S. Makia; Tirthankar Sinha; Shannon M. Conley; Muayyad R. Al-Ubaidi; Muna I. Naash

Tags: carrier proteins, flavins, retina, retinal degeneration, retinitis pigmentosa

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 17. doi:https://doi.org/10.1167/iovs.61.6.17

An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation Free

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Miki Hiraoka; Akira Abe

Tags: anticonvulsant hypersensitivity syndrome, macrophages, mice, mountain sickness, acute, phospholipids

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 23. doi:https://doi.org/10.1167/iovs.61.6.23

Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq Free

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Qing Zhang; Jian Zhang; Mengting Gong; Ruolan Pan; Yanchang Liu; Liming Tao; Kan He

Tags: fungal keratitis, gene expression profiling, mice, rna-seq, cytokine

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 32. doi:https://doi.org/10.1167/iovs.61.6.32

Opa1 Deficiency Leads to Diminished Mitochondrial Bioenergetics With Compensatory Increased Mitochondrial Motility Free

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Shanshan Sun; Irina Erchova; Frank Sengpiel; Marcela Votruba

Tags: bioenergetics, cell motility, mice, mitochondria, optic atrophy, autosomal dominant

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 42. doi:https://doi.org/10.1167/iovs.61.6.42

AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis Free

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Selikem Abla Nuwormegbe; Sun Woong Kim

Tags: aica ribonucleotide, alkalies, ampk, cornea, fibrosis

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 43. doi:https://doi.org/10.1167/iovs.61.6.43

The Role of the Dopamine D2 Receptor in Form-Deprivation Myopia in Mice: Studies With Full and Partial D2 Receptor Agonists and Knockouts Free

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Furong Huang; Qiongsi Wang; Tingting Yan; Jing Tang; Xueqin Hou; Ziheng Shu; Fen Wan; Yanan Yang; Jia Qu; Xiangtian Zhou

Tags: agonists, aripiprazole, mice, myopia, quinpirole

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 47. doi:https://doi.org/10.1167/iovs.61.6.47

Alteration in Lysophospholipids and Converting Enzymes in Glaucomatous Optic Nerves Free

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Sasha M. Milbeck; Sanjoy K. Bhattacharya

Tags: enzymes, glaucoma, lipids, lysophospholipids, optic nerve

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 60. doi:https://doi.org/10.1167/iovs.61.6.60

Clinical and Epidemiologic Research

Two-Dimensional, High-Resolution Peripheral Refraction in Adults with Isomyopia and Anisomyopia Free

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Sidi Wang; Zhenghua Lin; Xiaoyun Xi; Yiqiu Lu; Lun Pan; Xiaoning Li; Pablo Artal; Weizhong Lan; Zhikuan Yang

Tags: adult, eye, refraction, retina, myopia

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 16. doi:https://doi.org/10.1167/iovs.61.6.16

Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma Free

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Xinli Zhang; Lili Song; Yanxia Huang; Shaoping Han; Min Hou; Hongxia Li

Tags: down-regulation, micrornas, mitogen-activated protein kinases, retinoblastoma, neoplasms

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 28. doi:https://doi.org/10.1167/iovs.61.6.28

Cornea

Identification of a Primary Stroma and Novel Endothelial Cell Projections in the Developing Human Cornea Free

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Eleanor M. Feneck; Philip N. Lewis; Keith M. Meek

Tags: cornea, corneal stroma, endothelial cells, collagen, mesenchymal stem cells

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5. doi:https://doi.org/10.1167/iovs.61.6.5

Quasi-Static Optical Coherence Elastography to Characterize Human Corneal Biomechanical Properties Free

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Sabine Kling; Emilio A. Torres-Netto; Bogdan Spiru; Walter Sekundo; Farhad Hafezi

Tags: cornea, elasticity imaging techniques, optics, bowman's layer, intraocular pressure

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 29. doi:https://doi.org/10.1167/iovs.61.6.29

Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea Free

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Nicolás M. Díaz; Richard A. Lang; Russell N. Van Gelder; Ethan D. Buhr

Tags: cornea, mice

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 37. doi:https://doi.org/10.1167/iovs.61.6.37

Perillaldehyde Ameliorates Aspergillus fumigatus Keratitis by Activating the Nrf2/HO-1 Signaling Pathway and Inhibiting Dectin-1-Mediated Inflammation Free

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Yiqun Fan; Cui Li; Xudong Peng; Nan Jiang; Liting Hu; Lingwen Gu; Guoqiang Zhu; Guiqiu Zhao; Jing Lin

Tags: cornea, inflammation, keratitis, signal pathway, signal transduction pathways

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 51. doi:https://doi.org/10.1167/iovs.61.6.51

Topical Estrogen Therapy for Hyperopia Correction in Vivo Free

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Ari Leshno; Katalin Prokai-Tatrai; Ygal Rotenstreich; Asaf Magid; Ettel Bubis; Shulamit Schwartz; Alon Skaat; Ofira Zloto; Noa Avni-Zauberman; Adiel Barak

Tags: cornea, estrogen, estrogen therapy, hyperopia

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 55. doi:https://doi.org/10.1167/iovs.61.6.55

Quantitative Analysis of the Association Between Follow-Up Duration and Severity of Limbal Stem Cell Deficiency or Visual Acuity in Aniridia Free

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Shimpei Komoto; Yoshinori Oie; Satoshi Kawasaki; Ryo Kawasaki; Nozomi Nishida; Takeshi Soma; Shizuka Koh; Kazuichi Maruyama; Shinichi Usui; Kenji Matsushita; Motokazu Tsujikawa; Naoyuki Maeda; Kohji Nishida

Tags: aniridia, follow-up, limbal stem cell deficiency, visual acuity

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 57. doi:https://doi.org/10.1167/iovs.61.6.57

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Vertical Optokinetic Stimulation Induces Diagonal Eye Movements in Patients with Idiopathic Infantile Nystagmus Free

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John R. Economides; Young-Woo Suh; Joshua B. Simmons; Daniel L. Adams; Jonathan C. Horton

Tags: congenital nystagmus without sensory abnormality, eye movement, pathologic nystagmus, strabismus

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 14. doi:https://doi.org/10.1167/iovs.61.6.14

Two-Dimensional Analysis of Horizontal and Vertical Pursuit in Infantile Nystagmus Reveals Quantitative Deficits in Accuracy and Precision Free

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Lee Mcilreavy; Tom C. A. Freeman; Jonathan T. Erichsen

Tags: eye, pathologic nystagmus, precision, velocity

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 15. doi:https://doi.org/10.1167/iovs.61.6.15

Morphological Differences in the Inferior Oblique Muscles from Subjects with Over-elevation in Adduction Free

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Jolene C. Rudell; David Stager, Jr; Joost Felius; Linda K. McLoon

Tags: adduction, apert syndrome, inferior oblique muscle, muscle, previous surgery

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 33. doi:https://doi.org/10.1167/iovs.61.6.33

Suppression Rather Than Visual Acuity Loss Limits Stereoacuity in Amblyopia Free

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Ann L. Webber; Katrina L. Schmid; Alex S. Baldwin; Robert F. Hess

Tags: amblyopia, reduced visual acuity, filters, visual acuity

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 50. doi:https://doi.org/10.1167/iovs.61.6.50

Genetics

Genomewide Association Study of Acute Anterior Uveitis Identifies New Susceptibility Loci Free

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Xiu-Feng Huang; Zhixiu Li; Erika De Guzman; Philip Robinson; Lianne Gensler; Michael M. Ward; Mohammad Hossein Rahbar; MinJae Lee; Michael H. Weisman; Gary J. Macfarlane; Gareth T. Jones; Eva Klingberg; Helena Forsblad-d'Elia; Peter McCluskey; Denis Wakefield; Jeff S. Coombes; Maria A. Fiatarone Singh; Yorgi Mavros; Nicole Vlahovich; David C. Hughes; Helena Marzo-Ortega; Irene Van der Horste-Bruinsma; Finbar O'Shea; Tammy M. Martin; James Rosenbaum; Maxime Breban; Zi-Bing Jin; Paul Leo; John D. Reveille; B. Paul Wordsworth; Matthew A. Brown

Tags: disease susceptibility, genome-wide association study, single nucleotide polymorphism, uveitis, anterior, imputation

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3. doi:https://doi.org/10.1167/iovs.61.6.3

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration Free

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Thomas M. Hallam; Kevin J. Marchbank; Claire L. Harris; Clive Osmond; Victoria G. Shuttleworth; Helen Griffiths; Angela J. Cree; David Kavanagh; Andrew J. Lotery

Tags: age-related macular degeneration, cohort studies, complement factor i, cultural formulation interview, fibrinogen

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 18. doi:https://doi.org/10.1167/iovs.61.6.18

Glaucoma

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts Free

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Kaku Itoh; Fumihito Hikage; Yosuke Ida; Hiroshi Ohguro

Tags: agonists, fibroblasts, organoids, prostaglandins, prostaglandins, synthetic

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 13. doi:https://doi.org/10.1167/iovs.61.6.13

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype Free

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Kamesh Dhamodaran; Hasna Baidouri; Lyndsey Sandoval; VijayKrishna Raghunathan

Tags: actins, cytoskeleton, donors, genes, pathology

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 30. doi:https://doi.org/10.1167/iovs.61.6.30

Lamina Cribrosa Moves Anteriorly After Trabeculectomy in Myopic Eyes Free

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Seung Hyen Lee; Eun Ji Lee; Joon Mo Kim; Michaël J. A. Girard; Jean Martial Mari; Tae-Woo Kim

Tags: cribriform plate, eye, myopia, trabeculectomy, intraocular pressure

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 36. doi:https://doi.org/10.1167/iovs.61.6.36

VIP Induces Changes in the F-/G-Actin Ratio of Schlemm's Canal Endothelium via LRRK2 Transcriptional Regulation Free

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Xiaoqin Yan; Mu Li; Zhaoxia Luo; Yin Zhao; Hong Zhang; Liwen Chen

Tags: actins, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, endothelium, rats

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 45. doi:https://doi.org/10.1167/iovs.61.6.45

Immunology and Microbiology

Role of T_H17 Responses in Increasing Herpetic Keratitis in the Eyes of Mice Infected with HSV-1 Free

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Satoshi Hirose; Ujjaldeep Jaggi; Shaohui Wang; Kati Tormanen; Yoshiko Nagaoka; Makoto Katsumata; Homayon Ghiasi

Tags: eye, human herpesvirus 1, interleukin-17, mice, eye diseases

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 20. doi:https://doi.org/10.1167/iovs.61.6.20

Alterations in the Ocular Surface Microbiome in Traumatic Corneal Ulcer Patients Free

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Yutong Kang; Hao Zhang; Meina Hu; Yao Ma; Pengfei Chen; Zelin Zhao; Jinyang Li; Yuee Ye; Meiqin Zheng; Yongliang Lou

Tags: corneal ulcer, microbiome

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 35. doi:https://doi.org/10.1167/iovs.61.6.35

HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM Free

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Oleg Alekseev; William E. Donegan; Kelly R. Donovan; Vladimir Limonnik; Jane Azizkhan-Clifford

Tags: dna damage, human herpesvirus 1, infections, corneal epithelial cells, cornea

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 39. doi:https://doi.org/10.1167/iovs.61.6.39

Lens

Tropomyosin 3.1 Association With Actin Stress Fibers is Required for Lens Epithelial to Mesenchymal Transition Free

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Justin Parreno; Michael B. Amadeo; Elizabeth H. Kwon; Velia M. Fowler

Tags: actins, epithelial to mesenchymal transition, lens (device), lens epithelial cell, lens, crystalline

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2. doi:https://doi.org/10.1167/iovs.61.6.2

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens Free

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Nicholas A. Delamere; Mohammad Shahidullah; Richard T. Mathias; Junyuan Gao; Xiuron Sun; Caterina Sellitto; Thomas W. White

Tags: gap junction protein, hydrostatic pressure, lens (device), lens, crystalline, trpv1 receptor

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 58. doi:https://doi.org/10.1167/iovs.61.6.58

Low Vision

Relationship of Contrast Sensitivity Measured Using Quick Contrast Sensitivity Function With Other Visual Functions in a Low Vision Population Free

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Amritha Stalin; Kristine Dalton

Tags: contrast sensitivity, vision, visual impairment, linear regression

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 21. doi:https://doi.org/10.1167/iovs.61.6.21

Relationship Between Acuity and Contrast Sensitivity: Differences Due to Eye Disease Free

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Ying-Zi Xiong; MiYoung Kwon; Ava K. Bittner; Gianni Virgili; Giovanni Giacomelli; Gordon E. Legge

Tags: contrast sensitivity, eye diseases, cataract, glaucoma, pathology

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 40. doi:https://doi.org/10.1167/iovs.61.6.40

Multidisciplinary Ophthalmic Imaging

Retinal Vascular Reactivity in Type 1 Diabetes Patients Without Retinopathy Using Optical Coherence Tomography Angiography Free

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David Cordeiro Sousa; Inês Leal; Susana Moreira; Sónia do Vale; Ana S. Silva-Herdade; Patrício Aguiar; Patrícia Dionísio; Luís Abegão Pinto; Miguel A. R. B. Castanho; Carlos Marques-Neves

Tags: angiogram, challenge tests, diabetes mellitus, type 1, hypoxia, optical coherence tomography

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 49. doi:https://doi.org/10.1167/iovs.61.6.49

Longitudinal Structural and Microvascular Observation in RCS Rat Eyes Using Optical Coherence Tomography Angiography Free

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Bingyao Tan; Veluchamy A. Barathi; Emily Lin; Candice Ho; Alfred Gan; Xinwen Yao; Anita Chan; Damon W.K. Wong; Jacqueline Chua; Gavin S. Tan; Leopold Schmetterer

Tags: angiogram, eye, optical coherence tomography, rats, retina

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 54. doi:https://doi.org/10.1167/iovs.61.6.54

Physiology and Pharmacology

Intra-Subject Variability and Diurnal Cycle of Ocular Perfusion Pressure as Characterized by Continuous Telemetry in Nonhuman Primates Free

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Katherine I. Wilson; Pooja Godara; Jessica V. Jasien; Emma Zohner; Jeffrey S. Morris; Christopher A. Girkin; Brian C. Samuels; J. Crawford Downs

Tags: calibration, intraocular pressure, perfusion, primates, telemetry

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 7. doi:https://doi.org/10.1167/iovs.61.6.7

Mechanisms of Ion Transport Across the Mouse Retinal Pigment Epithelium Measured In Vitro Free

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Sunna Bjorg Skarphedinsdottir; Thor Eysteinsson; Sighvatur Sævar Árnason

Tags: ion transport, mice, retinal pigment epithelium, bathing, epinephrine

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 31. doi:https://doi.org/10.1167/iovs.61.6.31

Retina

Association Between Alterations of the Choriocapillaris Microcirculation and Visual Function and Cone Photoreceptors in Patients With Diabetes Free

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Tomoko Ro-Mase; Satoshi Ishiko; Tsuneaki Omae; Akihiro Ishibazawa; Akito Shimouchi; Akitoshi Yoshida

Tags: diabetes mellitus, diabetes mellitus, type 2, microcirculation, retinal cone, retinal imaging

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1. doi:https://doi.org/10.1167/iovs.61.6.1

Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages Free

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Ailing Sui; Xiuping Chen; Anna M. Demetriades; Jikui Shen; Yujuan Cai; Yiyun Yao; Yixuan Yao; Yanji Zhu; Xi Shen; Bing Xie

Tags: macrophages, mice, retina, retinal neovascularization, signal transduction

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4. doi:https://doi.org/10.1167/iovs.61.6.4

Electroretinogram of the Cone-Dominant Thirteen-Lined Ground Squirrel during Euthermia and Hibernation in Comparison with the Rod-Dominant Brown Norway Rat Free

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Hanmeng Zhang; Benjamin S. Sajdak; Dana K. Merriman; Maureen A. McCall; Joseph Carroll; Daniel M. Lipinski

Tags: electroretinography, hibernating myocardium, rats, inbred bn, retinal cone, rod photoreceptors

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 6. doi:https://doi.org/10.1167/iovs.61.6.6

All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion Free

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Alyssa Dreffs; Cheng-Mao Lin; Xuwen Liu; Sumathi Shanmugam; Steven F. Abcouwer; Timothy S. Kern; David A. Antonetti

Tags: endothelial cells, ischemia, mice, permeability, physiologic reperfusion

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 8. doi:https://doi.org/10.1167/iovs.61.6.8

Subretinal Drusenoid Deposits and Photoreceptor Loss Detecting Global and Local Progression of Geographic Atrophy by SD-OCT Imaging Free

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Gregor S. Reiter; Reinhard Told; Markus Schranz; Lukas Baumann; Georgios Mylonas; Stefan Sacu; Andreas Pollreisz; Ursula Schmidt-Erfurth

Tags: atrophy, diagnostic imaging, digestive tract decontamination, photoreceptors, spectral domain-optical coherence tomography

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 11. doi:https://doi.org/10.1167/iovs.61.6.11

Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases Free

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Kathrin Kaehler; Hartwig Seitter; Adolf M. Sandbichler; Bettina Tschugg; Gerald J. Obermair; Nadia Stefanova; Alexandra Koschak

Tags: mice, retina

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 12. doi:https://doi.org/10.1167/iovs.61.6.12

Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/β-Catenin Axis Free

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Xueman Lyv; Fei Wu; Hong Zhang; Jia Lu; Lina Wang; Yunhai Ma

Tags: luciferases, micrornas, neoplasm metastasis, polymerase chain reaction, retinoblastoma

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 41. doi:https://doi.org/10.1167/iovs.61.6.41

Volume Rendering of Dense B-Scan Optical Coherence Tomography Angiography to Evaluate the Connectivity of Macular Blood Flow Free

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Diogo Cabral; Telmo Pereira; Gerardo Ledesma-Gil; Catarina Rodrigues; Florence Coscas; David Sarraf; K. Bailey Freund

Tags: angiogram, optical coherence tomography, vascular flow, volume rendering, blood capillaries

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 44. doi:https://doi.org/10.1167/iovs.61.6.44

Imaging of Macrophage-Like Cells in Living Human Retina Using Clinical OCT Free

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Maria V. Castanos; Davis B. Zhou; Rachel E. Linderman; Reilly Allison; Tatyana Milman; Joseph Carroll; Justin Migacz; Richard B. Rosen; Toco Y.P. Chui

Tags: diagnostic imaging, macrophages, retina

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 48. doi:https://doi.org/10.1167/iovs.61.6.48

Visual Field Progression in Retinitis Pigmentosa Free

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Manlong Xu; Yi Zhai; Ian M. MacDonald

Tags: retinitis pigmentosa, visual fields, blindness, survival analysis

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 56. doi:https://doi.org/10.1167/iovs.61.6.56

Macular Thickness in Intermediate Age-Related Macular Degeneration Is Influenced by Disease Severity and Subretinal Drusenoid Deposit Presence Free

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Trent Tsun-Kang Chiang; Tiarnan D. Keenan; Elvira Agrón; Jennifer Liao; Brandon Klein; Emily Y. Chew; Catherine A. Cukras; Wai T. Wong

Tags: age-related macular degeneration, digestive tract decontamination, eye, severity of illness, drusen

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 59. doi:https://doi.org/10.1167/iovs.61.6.59

Optical Coherence Tomography Angiography Quantitative Assessment of Macular Neovascularization in Best Vitelliform Macular Dystrophy Free

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Maurizio Battaglia Parodi; Alessandro Arrigo; Francesco Bandello

Tags: angiogram, follow-up, neovascularization, pathologic, optical coherence tomography, vitelliform dystrophy

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 61. doi:https://doi.org/10.1167/iovs.61.6.61

Retinal Cell Biology

Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes Free

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Alpha Alex; Qianyi Luo; Deepa Mathew; Rong Di; Ashay D. Bhatwadekar

Tags: metformin, mice, diabetes mellitus, type 2, diabetes mellitus, circadian rhythms

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 46. doi:https://doi.org/10.1167/iovs.61.6.46

Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions Free

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Di Wu; Kousuke Noda; Miyuki Murata; Ye Liu; Atsuhiro Kanda; Susumu Ishida

Tags: hypoxia, neuroglia, spermine, oxidase, signal transduction

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 52. doi:https://doi.org/10.1167/iovs.61.6.52

Visual Neuroscience

Effects of Cone Connexin-36 Disruption on Light Adaptation and Circadian Regulation of the Photopic ERG Free

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Shuo Zhang; Polina Lyuboslavsky; Jendayi Azeezah Dixon; Micah A. Chrenek; Jana T. Sellers; Jessica M. Hamm; Christophe P. Ribelayga; Zhijing Zhang; Yun Z. Le; P. Michael Iuvone

Tags: electroretinography, gap junction protein, light adaptation, mice, retinal cone

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 24. doi:https://doi.org/10.1167/iovs.61.6.24

Full-Field Electroretinography, Pupillometry, and Luminance Thresholds in X-Linked Retinoschisis Free

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J. Jason McAnany; Jason C. Park; Gerald A. Fishman; Frederick T. Collison

Tags: electroretinography, luminance, x-linked retinoschisis, pupillometry, passive leg raising

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 53. doi:https://doi.org/10.1167/iovs.61.6.53

Visual Psychophysics and Physiological Optics

The Effect of Age-Related Macular Degeneration on Components of Face Perception Free

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Andrew J. Logan; Gael E. Gordon; Gunter Loffler

Tags: face, facial recognition, age-related macular degeneration, vision

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 38. doi:https://doi.org/10.1167/iovs.61.6.38

Perspective

Cell Line Authentication in Vision Research and Beyond: A Tale Retold Free

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Jeremy Peavey; Goldis Malek

Tags: cell line authentication, endothelial cells, vision research, cell lines

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 19. doi:https://doi.org/10.1167/iovs.61.6.19

Letters to the Editor

Author Response: Letter to the Editor of IOVS From Joseph L. Demer and Robert A. Clark Regarding Joel M. Miller, “EOM Pulleys and Sequelae: A Critical Review” Free

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Joel M. Miller

Tags: magnetic resonance imaging, muscle, muscle contraction, science, validity of results

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 9. doi:https://doi.org/10.1167/iovs.61.6.9

Letter to the Editor of IOVS From Joseph L. Demer and Robert A. Clark Regarding Joel M. Miller, “EOM Pulleys and Sequelae: A Critical Review” Free

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Joseph L. Demer; Robert A. Clark

Tags: kinematics, magnetic resonance imaging, muscle, muscle of orbit, oculomotor system

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 10. doi:https://doi.org/10.1167/iovs.61.6.10

Intralenticular Hydrostatic Pressure Increases During Ciliary Muscle Contraction: A Finding Consistent With the Schachar Mechanism of Accommodation Free

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Ronald A. Schachar; Ira H. Schachar

Tags: ciliary muscle, hydrostatic pressure, visual accommodation

Investigative Ophthalmology & Visual Science June 2020, Vol.61, 34. doi:https://doi.org/10.1167/iovs.61.6.34

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