Volume 61 Issue 11 | IOVS

Calculating Sensitivity, Specificity, and Predictive Values for Correlated Eye Data Open Access

Gui-Shuang Ying; Maureen G. Maguire; Robert J. Glynn; Bernard Rosner

Tags: eye, sensitivity and specificity

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 29. doi:https://doi.org/10.1167/iovs.61.11.29

Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights Open Access

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Jarrod C. Harman; Jessie J. Guidry; Jeffrey M. Gidday

Tags: did not receive therapy or drug, hypoxia, ischemia, mice, offspring

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 15. doi:https://doi.org/10.1167/iovs.61.11.15

VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions Open Access

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María Llorián-Salvador; Peter Barabas; Eimear M. Byrne; Judith Lechner; Josy Augustine; Timothy M. Curtis; Mei Chen; Heping Xu

Tags: vascular endothelial growth factor b, vascular endothelial growth factor a, hypoxia

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 35. doi:https://doi.org/10.1167/iovs.61.11.35

Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells Open Access

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Toshiro Iwagawa; Hiroaki Honda; Sumiko Watanabe

Tags: abdominal compartment syndrome, acute coronary syndromes, american cancer society, american college of surgeons, human placental lactogen

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 43. doi:https://doi.org/10.1167/iovs.61.11.43

Clinical and Epidemiologic Research

Effect of Education on Myopia: Evidence from the United Kingdom ROSLA 1972 Reform Open Access

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Denis Plotnikov; Cathy Williams; Denize Atan; Neil M. Davies; Neema Ghorbani Mojarrad; Jeremy A. Guggenheim; for the UK Biobank Eye and Vision Consortium

Tags: knowledge acquisition, myopia, refractive errors, genetic predisposition to disease

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 7. doi:https://doi.org/10.1167/iovs.61.11.7

Gender-Specific Association Between Serum Uric Acid and Incident High Intraocular Pressure in Chinese Population: A Cross-Sectional Study Open Access

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Qianqian Liu; Dan Liu; Derui Yan; Weicun Huang; Xiaodong Ji; Jie Hui; Zaixiang Tang

Tags: intraocular pressure, urate measurement, serum, uric acid, gender, chinese (other dialects)

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 10. doi:https://doi.org/10.1167/iovs.61.11.10

Prevalence and Risk Factors of Epiretinal Membranes in a Chinese Population: The Kailuan Eye Study Open Access

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Xiao Bo Zhu; Mo Chi Yang; Ya Xing Wang; Wang Qian; Yan Ni Yan; Jing Yan Yang; Shou Ling Wu; Shuo Hua Chen; Li Dong; Wen Bin Wei; Jost B. Jonas

Tags: chinese (other dialects), chinese people, epiretinal membrane, eye, prevalence

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 37. doi:https://doi.org/10.1167/iovs.61.11.37

Cornea

Diurnal Control of Sensory Axon Growth and Shedding in the Mouse Cornea Open Access

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Sonali Pal-Ghosh; Gauri Tadvalkar; Beverly A. Karpinski; Mary Ann Stepp

Tags: axon, cornea, lights, manufactured, mice, regulation

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 1. doi:https://doi.org/10.1167/iovs.61.11.1

Effect of High Glucose on Ocular Surface Epithelial Cell Barrier and Tight Junction Proteins Open Access

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Saleh Alfuraih; Ashley Barbarino; Christopher Ross; Kiumars Shamloo; Vishal Jhanji; Miao Zhang; Ajay Sharma

Tags: glucose, proteins, tight junctions, epithelial cells, cornea

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 3. doi:https://doi.org/10.1167/iovs.61.11.3

S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway Open Access

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Yulin Wang; Guiping Gao; Ying Wu; Yuqin Wang; Xiaorong Wu; Qiong Zhou

Tags: alkalies, burns, cornea, proto-oncogene proteins c-akt, s100 calcium-binding protein a4

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 19. doi:https://doi.org/10.1167/iovs.61.11.19

COL8A2 Regulates the Fate of Corneal Endothelial Cells Open Access

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Jin Sun Hwang; Dae Joong Ma; Jinju Choi; Young Joo Shin

Tags: chronic exertional compartment syndrome, cornea, endothelial cells, transfection, mitochondria

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 26. doi:https://doi.org/10.1167/iovs.61.11.26

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Associations of Eye-Related Quality of Life With Vision, Visuomotor Function, and Self-Perception in Children With Strabismus and Anisometropia Open Access

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Eileen E. Birch; Yolanda S. Castañeda; Christina S. Cheng-Patel; Sarah E. Morale; Krista R. Kelly; Reed M. Jost; Lindsey A. Hudgins; David A. Leske; Jonathan M. Holmes

Tags: anisometropia, child, eye, quality of life, self-perception

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 22. doi:https://doi.org/10.1167/iovs.61.11.22

Dichoptic Spatial Contrast Sensitivity Reflects Binocular Balance in Normal and Stereoanomalous Subjects Open Access

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Mirella Telles Salgueiro Barboni; Otto Alexander Maneschg; János Németh; Zoltán Zsolt Nagy; Zoltán Vidnyánszky; Éva M. Bankó

Tags: amblyopia, autism spectrum disorder, balance, device, contrast sensitivity, equilibrium

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 23. doi:https://doi.org/10.1167/iovs.61.11.23

Fixation Preference for Visual and Auditory Targets in Monkeys with Strabismus Open Access

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Santoshi Ramachandran; Vallabh E. Das

Tags: cercopithecidae, eye, maps, saccades, strabismus

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 24. doi:https://doi.org/10.1167/iovs.61.11.24

Genetics

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects Open Access

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Mark J. Simcoe; Anthony P. Khawaja; Omar A. Mahroo; Christopher J. Hammond; Pirro G. Hysi; for the UK Biobank Eye and Vision Consortium

Tags: intraocular pressure, open-angle glaucoma, x chromosomes, single nucleotide polymorphism, biobanks

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 20. doi:https://doi.org/10.1167/iovs.61.11.20

Glaucoma

Angular Location of Retinal Nerve Fiber Layer Defect: Association With Myopia and Open-Angle Glaucoma Open Access

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Eunoo Bak; Kyoung Min Lee; Martha Kim; Sohee Oh; Seok Hwan Kim

Tags: glaucoma, malformation association, myopia, open-angle glaucoma, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 13. doi:https://doi.org/10.1167/iovs.61.11.13

Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve Open Access

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Yik Tung Tracy Ling; Mary E. Pease; Joan L. Jefferys; Elizabeth C. Kimball; Harry A. Quigley; Thao D. Nguyen

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 14. doi:https://doi.org/10.1167/iovs.61.11.14

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position Open Access

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Takashi Omoto; Hiroshi Murata; Yuri Fujino; Masato Matsuura; Takashi Fujishiro; Kazunori Hirasawa; Takehiro Yamashita; Takashi Kanamoto; Atsuya Miki; Yoko Ikeda; Kazuhiko Mori; Masaki Tanito; Kenji Inoue; Junkichi Yamagami; Ryo Asaoka

Tags: central retinal artery, eye, ganglia

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 16. doi:https://doi.org/10.1167/iovs.61.11.16

Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study Open Access

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Nigus G. Asefa; Anna Neustaeter; Nomdo M. Jansonius; Harold Snieder

Tags: glaucoma, autonomic dysfunction, cohort studies, blood pressure

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 25. doi:https://doi.org/10.1167/iovs.61.11.25

Effect of Electrical Stimulation of Cervical Sympathetic Ganglia on Intraocular Pressure Regulation According to Different Circadian Rhythms in Rats Open Access

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Zhaoxia Luo; Mu Li; Meng Ye; Pingting Ji; Xiaotong Lou; Jingqiu Huang; Ke Yao; Yin Zhao; Hong Zhang

Tags: circadian rhythms, electric stimulation, intraocular pressure, rats, rhythm

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 40. doi:https://doi.org/10.1167/iovs.61.11.40

Immunology and Microbiology

Comprehensive miRNA Analysis Using Serum From Patients With Noninfectious Uveitis Open Access

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Masaki Asakage; Yoshihiko Usui; Naoya Nezu; Hiroyuki Shimizu; Kinya Tsubota; Naoyuki Yamakawa; Masakatsu Takanashi; Masahiko Kuroda; Hiroshi Goto

Tags: micrornas, uveitis

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 4. doi:https://doi.org/10.1167/iovs.61.11.4

Evaluation of Susceptibility and Innate Immune Response in C57BL/6 and BALB/c Mice During Candida albicans Endophthalmitis Open Access

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Bruce G. Rottmann; Pawan Kumar Singh; Sneha Singh; Sanjay G. Revankar; Pranatharthi H. Chandrasekar; Ashok Kumar

Tags: candida, disease susceptibility, endophthalmitis, eye, mice

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 31. doi:https://doi.org/10.1167/iovs.61.11.31

Lens

Cohen Syndrome-Associated Cataract Is Explained by VPS13B Functions in Lens Homeostasis and Is Modified by Additional Genetic Factors Open Access

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Vincent Lhussiez; Elisabeth Dubus; Quénol Cesar; Niyazi Acar; Emeline F. Nandrot; Manuel Simonutti; Isabelle Audo; Eléonore Lizé; Sylvie Nguyen; Audrey Geissler; André Bouchot; Muhammad Ansar; Serge Picaud; Christel Thauvin-Robinet; Laurence Olivier-Faivre; Laurence Duplomb; Romain Da Costa

Tags: cataract, lens (device), lens, crystalline, genetic aspects, cohen syndrome

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 18. doi:https://doi.org/10.1167/iovs.61.11.18

Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens Open Access

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Rosica S. Petrova; Nandini Bavana; Rusin Zhao; Kevin L. Schey; Paul J. Donaldson

Tags: lens (device), lens, crystalline, tissue membrane, water

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 36. doi:https://doi.org/10.1167/iovs.61.11.36

Multidisciplinary Ophthalmic Imaging

The Fovea in Retinopathy of Prematurity Open Access

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James D. Akula; Ivana A. Arellano; Emily A. Swanson; Tara L. Favazza; Theodore S. Bowe; Robert J. Munro; R. Daniel Ferguson; Ronald M. Hansen; Anne Moskowitz; Anne B. Fulton

Tags: fovea centralis, retinopathy of prematurity, retinal cone

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 28. doi:https://doi.org/10.1167/iovs.61.11.28

Physiology and Pharmacology

Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris Open Access

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Soufien Sghari; Wayne I. L. Davies; Lena Gunhaga

Tags: acetylcholine, eye, immune reconstitution inflammatory syndrome, iris, mammals

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 5. doi:https://doi.org/10.1167/iovs.61.11.5

Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes Open Access

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Syed A. H. Zaidi; Nakul Thakore; Sudha Singh; Wendy Guzman; Shikhar Mehrotra; Vamsi Gangaraju; Shahid Husain

Tags: astrocytes, histone deacetylase, opioids, optic disk, proteins

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 17. doi:https://doi.org/10.1167/iovs.61.11.17

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia Open Access

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Michael L. De Ieso; Jami M. Gurley; Mark E. McClellan; Xiaowu Gu; Iris Navarro; Guorong Li; Maria Gomez-Caraballo; Eric Enyong; W. Daniel Stamer; Michael H. Elliott

Tags: ablation, caveolins, endothelium, intraocular pressure, mice

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 32. doi:https://doi.org/10.1167/iovs.61.11.32

Retina

Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition Open Access

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Rebekah Robinson; Hannah Youngblood; Hersha Iyer; Justin Bloom; Tae Jin Lee; Luke Chang; Zachary Lukowski; Wenbo Zhi; Ashok Sharma; Shruti Sharma

Tags: diabetes mellitus, interleukin-6, mice, proteins, proteome

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 2. doi:https://doi.org/10.1167/iovs.61.11.2

Fluorescence Lifetimes and Spectra of RPE and Sub-RPE Deposits in Histology of Control and AMD Eyes Open Access

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Rowena Schultz; Kushmali C. L. K. Gamage; Jeffrey D. Messinger; Christine A. Curcio; Martin Hammer

Tags: autofluorescence, eye, fluorescence, histology, donors

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 9. doi:https://doi.org/10.1167/iovs.61.11.9

Choriocapillaris Flow Deficits and Treatment-Naïve Macular Neovascularization Secondary to Age-Related Macular Degeneration Open Access

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Jackson M. Scharf; Giulia Corradetti; Ahmed Roshdy Alagorie; Christelle Grondin; Assaf Hilely; Derrick Wang; SriniVas Sadda; David Sarraf

Tags: age-related macular degeneration, chief complaint, eye, fluid flow, neovascularization, pathologic

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 11. doi:https://doi.org/10.1167/iovs.61.11.11

Effects of Systemic Profiles on Choroidal Thickness in Treatment-Naïve Eyes With Diabetic Retinopathy Open Access

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Min Gyu Choi; Hum Chung; Young Hee Yoon; Jee Taek Kim

Tags: diabetic retinopathy, eye, diabetes mellitus, type 2, diabetes mellitus, nonproliferative diabetic retinopathy

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 12. doi:https://doi.org/10.1167/iovs.61.11.12

Clinical Characteristics of Neuronal Intranuclear Inclusion Disease-Related Retinopathy With CGG Repeat Expansions in the NOTCH2NLC Gene Open Access

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Natsuko Nakamura; Kazushige Tsunoda; Akihiko Mitsutake; Shota Shibata; Tatsuo Mano; Yu Nagashima; Hiroyuki Ishiura; Atsushi Iwata; Tatsushi Toda; Shoji Tsuji; Hiromasa Sawamura

Tags: genes, neuronal intranuclear inclusion disease, retinal diseases, signs and symptoms

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 27. doi:https://doi.org/10.1167/iovs.61.11.27

Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa Open Access

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Ayako Okita; Yusuke Murakami; Shotaro Shimokawa; Jun Funatsu; Kohta Fujiwara; Shunji Nakatake; Yoshito Koyanagi; Masato Akiyama; Atsunobu Takeda; Toshio Hisatomi; Yasuhiro Ikeda; Koh-Hei Sonoda

Tags: chemokines, cytokine, molecule, retinitis pigmentosa, vision

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 30. doi:https://doi.org/10.1167/iovs.61.11.30

Long-Term Investigation of Retinal Function in Patients with Achromatopsia Open Access

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Michalis Georgiou; Navjit Singh; Thomas Kane; Serena Zaman; Nashila Hirji; Jonathan Aboshiha; Neruban Kumaran; Angelos Kalitzeos; Joseph Carroll; Richard G. Weleber; Michel Michaelides

Tags: achromatopsia, eye, follow-up, cohort studies, genotype

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 38. doi:https://doi.org/10.1167/iovs.61.11.38

Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy Open Access

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Nikhil Mandava; Vanessa Tirado-Gonzalez; Matthew D. Geiger; Jennifer L. Patnaik; Ashley Frazer-Abel; Anne M. Lynch; Naresh Mandava; Alan G. Palestine; V. Michael Holers; Brandie D. Wagner; Idaira Sanchez-Santos; Daniela Meizner; Hugo Quiroz-Mercado; Jesse M. Smith

Tags: complement activation, complement system proteins, diabetic retinopathy, proliferative diabetic retinopathy, vitreous body

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 39. doi:https://doi.org/10.1167/iovs.61.11.39

Quantitative Fundus Autofluorescence in HCQ Retinopathy Open Access

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Vivienne C. Greenstein; Jose Ronaldo Lima de Carvalho, Jr.; Rait Parmann; Luz Amaro-Quireza; Winston Lee; Donald C. Hood; Stephen H. Tsang; Janet R. Sparrow

Tags: fundus autofluorescence imaging, retinal diseases, spectral domain-optical coherence tomography, visual fields, eye

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 41. doi:https://doi.org/10.1167/iovs.61.11.41

Retinal Cell Biology

Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration Open Access

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Hideyuki Shimizu; Kazuhisa Yamada; Ayana Suzumura; Keiko Kataoka; Kei Takayama; Masataka Sugimoto; Hiroko Terasaki; Hiroki Kaneko

Tags: caveolins, fibrosis, mice, retinal pigment cell, cellular senescence

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 21. doi:https://doi.org/10.1167/iovs.61.11.21

Epac1 Requires AMPK Phosphorylation to Regulate HMGB1 in the Retinal Vasculature Open Access

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Youde Jiang; Jena J. Steinle

Tags: ampk, hmgb1 protein, phosphorylation, retina, retinal vasculature

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 33. doi:https://doi.org/10.1167/iovs.61.11.33

Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction Open Access

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Bin Lin; Bryce T. McLelland; Robert B. Aramant; Biju B. Thomas; Gabriel Nistor; Hans S. Keirstead; Magdalene J. Seiler

Tags: organoids, pathophysiology, photoreceptors, rats, rats, nude

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 34. doi:https://doi.org/10.1167/iovs.61.11.34

Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor Precursors Open Access

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Revital Schick; Nairouz Farah; Amos Markus; Alon Korngreen; Yossi Mandel

Tags: calcium, embryo, photoreceptors, polymerase chain reaction, voltage

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 44. doi:https://doi.org/10.1167/iovs.61.11.44

Visual Neuroscience

Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy Open Access

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Pieter B. de Best; Ruth Abulafia; Ayelet McKyton; Netta Levin

Tags: posterior cortical atrophy syndrome, primary visual cortex, voxel, atrophy

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 8. doi:https://doi.org/10.1167/iovs.61.11.8

The Spatial Frequency Content of Urban and Indoor Environments as a Potential Risk Factor for Myopia Development Open Access

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Daniel Ian Flitcroft; Elise N. Harb; Christine Frances Wildsoet

Tags: myopia, spatial frequency, risk factors

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 42. doi:https://doi.org/10.1167/iovs.61.11.42

Retraction

Retraction Open Access

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Tags: cornea, endothelial cells, ophthalmology, spinal cord injuries, transcription factor 4

Investigative Ophthalmology & Visual Science September 2020, Vol.61, 6. doi:https://doi.org/10.1167/iovs.61.11.6

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