Volume 62 Issue 2 | IOVS

Anatomy and Pathology/Oncology

Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult Open Access

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Rami Halabi; Charlene Watterston; Carrie Lynn Hehr; Risa Mori-Kreiner; Sarah J. Childs; Sarah McFarlane

Tags: adult, embryo, retina, semaphorins, eye

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.2.21

Early Astigmatism Can Alter Myopia Development in Chickens Open Access

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Sonal Aswin Vyas; Chea-su Kee

Tags: astigmatism, cornea, eye, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.2.27

Biochemistry and Molecular Biology

Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium Open Access

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Nicholas P. Boyer; Debra A. Thompson; Yiannis Koutalos

Tags: lipofuscin, mice, retinal pigment epithelium, retinoids

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.2.1

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R) Open Access

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Jeanee Bullock; Federica Polato; Mones Abu-Asab; Alexandra Bernardo-Colón; Elma Aflaki; Martin-Paul Agbaga; S. Patricia Becerra

Tags: catabolism, epithelium, lipids, mice, phagocytosis

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.2.30

Clinical and Epidemiologic Research

Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort Open Access

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Karina Patasova; Anthony P. Khawaja; Bani Tamraz; Katie M. Williams; Omar A. Mahroo; Maxim Freidin; Ameenat L. Solebo; Jelle Vehof; Mario Falchi; Jugnoo S. Rahi; Chris J. Hammond; Pirro G. Hysi

Tags: cohort studies, pharmaceutical preparations, refraction, refractive errors, drug usage

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.2.15

Cornea

Proteome Composition of Bovine Amniotic Membrane and Its Potential Role in Corneal Healing Open Access

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Erotides Capistrano da Silva; Justine Arrington; Peter M. Yau; Kathryn M. Smith-Fleming; Igor Frederico Canisso; Bianca da Costa Martins

Tags: amnion, cattle, cornea, proteins, healing process

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.2.11

Hedgehog Signaling Pathway Regulates the Proliferation and Differentiation of Rat Meibomian Gland Epithelial Cells Open Access

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Jing-Yu Qu; Yu-Ting Xiao; Ying-Ying Zhang; Hua-Tao Xie; Ming-Chang Zhang

Tags: epithelial cells, erinaceidae, hedgehog signaling pathway, meibomian gland, regulation

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 33. doi:https://doi.org/10.1167/iovs.62.2.33

Associations Between Regional Environment and Cornea-Related Morphology of the Eye in Young Adults: A Large-Scale Multicenter Cross-Sectional Study Open Access

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Jiaonan Ma; Lanqin Zhao; Yahan Yang; Dongyuan Yun; Patrick Yu-Wai-Man; Yi Zhu; Chuan Chen; Ji-Peng Olivia Li; Mengdi Li; Yan Zhang; Tingxin Cui; Xiangbing Meng; Lin Zhang; Jiamei Zhang; Yi Song; Yulin Lei; Jianguo Liu; Xiaojin Huangfu; Li Jiang; Jinfeng Cai; Huiying Wu; Liqiang Shang; Dan Wen; Xianglong Yi; Yan Zhang; Xin Li; Jing Xiao; Rui He; Yang Yang; Jun Yang; George P. M. Cheng; Ji Bai; Xingwu Zhong; Hua Guo; Pisong Yan; Yan Wang; Haotian Lin

Tags: cornea, eye, language morphology, morphology, young adult

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 35. doi:https://doi.org/10.1167/iovs.62.2.35

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Cytoskeletal Proteins in Myotendinous Junctions of Human Extraocular Muscles Open Access

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Jing-Xia Liu; Fatima Pedrosa Domellöf

Tags: antibodies, cytoskeletal proteins, desmin, keratins, muscle

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.2.19

The Flash-lag Effect in Amblyopia Open Access

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Xi Wang; Alexandre Reynaud; Robert F. Hess

Tags: amblyopia

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.2.23

Genetics

Molecular Epidemiology in 591 Italian Probands With Nonsyndromic Retinitis Pigmentosa and Usher Syndrome Open Access

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Leonardo Colombo; Paolo E. Maltese; Marco Castori; Said El Shamieh; Christina Zeitz; Isabelle Audo; Alessandra Zulian; Carla Marinelli; Sabrina Benedetti; Alisia Costantini; Simone Bressan; Marcella Percio; Paolo Ferri; Andi Abeshi; Matteo Bertelli; Luca Rossetti

Tags: epidemiology, molecular, genes, genetics, italian, proband

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.2.13

The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans Open Access

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Brian S. Cole; Harini V. Gudiseva; Maxwell Pistilli; Rebecca Salowe; Caitlin P. McHugh; Michael C. Zody; Venkata R. M. Chavali; Gui Shuang Ying; Jason H. Moore; Joan M. O'Brien

Tags: african american, genetics, glaucoma, open-angle glaucoma, risk factors

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.2.28

Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response Open Access

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S. P. B. Sardar Pasha; Trupti Shetty; Nathan A. Lambert-Cheatham; Kamakshi Sishtla; Deepa Mathew; Anbukkarasi Muniyandi; Neeta Patwari; Ashay D. Bhatwadekar; Timothy W. Corson

Tags: ferrochelatase, mice, protoporphyrins

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 36. doi:https://doi.org/10.1167/iovs.62.2.36

Glaucoma

The Progression of Peripapillary Retinoschisis May Indicate the Progression of Glaucoma Open Access

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Eun Jung Lee; Hyun Joo Kee; Jong Chul Han; Changwon Kee

Tags: glaucoma, retinoschisis, eye

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.2.16

Altered Iris Aquaporin Expression and Aqueous Humor Osmolality in Glaucoma Open Access

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Olivia S. Huang; Li-Fong Seet; Henrietta W. Ho; Stephanie W. Chu; Arun Narayanaswamy; Shamira A. Perera; Rahat Husain; Tin Aung; Tina T. Wong

Tags: aqueous humor, glaucoma, iris, osmolality, water channels

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 34. doi:https://doi.org/10.1167/iovs.62.2.34

Posture-Related Changes of Intraocular Pressure in Patients With Acute Primary Angle Closure Open Access

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Yun Hsia; Chien-Chia Su; Tsing-Hong Wang; Jehn-Yu Huang

Tags: eye, intraocular pressure, posture, phased thoracic-abdominal compression-decompression

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 37. doi:https://doi.org/10.1167/iovs.62.2.37

Immunology and Microbiology

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline Open Access

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Kirthana Senthil; Haihan Jiao; Laura E. Downie; Holly R. Chinnery

Tags: cornea, dendritic cells, epithelium, hyperosmolality, language morphology

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 38. doi:https://doi.org/10.1167/iovs.62.2.38

Characterization of Gene Therapy Associated Uveitis Following Intravitreal Adeno-Associated Virus Injection in Mice Open Access

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Gayathri Tummala; Adam Crain; Jessica Rowlan; Kathryn L. Pepple

Tags: adeno-associated virus, eye, gene therapy, inflammation, injections

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 41. doi:https://doi.org/10.1167/iovs.62.2.41

Multidisciplinary Ophthalmic Imaging

Follow-Up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography Open Access

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Edouard Augstburger; Arnaud Ballino; Chafik Keilani; Mathieu Robin; Christophe Baudouin; Antoine Labbé

Tags: angiogram, follow-up, nonarteritic anterior ischemic optic neuropathy, optical coherence tomography

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 42. doi:https://doi.org/10.1167/iovs.62.4.42

Physiology and Pharmacology

VEGFR2 Trafficking by KIF13B Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration Open Access

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Stephen B. Waters; Christopher Zhou; Tara Nguyen; Ruth Zelkha; Hyun Lee; Andrius Kazlauskas; Mark I. Rosenblatt; Asrar B. Malik; Kaori H. Yamada

Tags: choroidal neovascularization, exudative age-related macular degeneration, eyedrops, lasers, mice

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.2.5

Retinal Aquaporin-4 and Regulation of Water Inflow Into the Vitreous Body Open Access

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Satoshi Ueki; Yuji Suzuki; Hironaka Igarashi

Tags: regulation, vitreous body, water, water channels, mice

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.2.24

Retina

Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity Open Access

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Seong Joon Ahn; Joo Young Lee; Ji Young Lee; Young-Jun Lee; Jong-Min Lee; Byung Ro Lee; Jinsup Kim; Hyun Ju Lee

Tags: brain, infant, infant, premature, retinopathy of prematurity, white matter

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.2.2

Retinoblastoma Is Characterized by a Cold, CD8+ Cell Poor, PD-L1− Microenvironment, Which Turns Into Hot, CD8+ Cell Rich, PD-L1+ After Chemotherapy Open Access

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Clelia Miracco; Paolo Toti; Maria Chiara Gelmi; Sara Aversa; Gennaro Baldino; Paolo Galluzzi; Sonia De Francesco; Federica Petrelli; Ester Sorrentino; Giuseppe Belmonte; Daniela Galimberti; Sandra Bracco; Theodora Hadjistilianou

Tags: cd8-positive t-lymphocytes, chemotherapy regimen, ciliary motility disorders, cold sensation, cold temperature

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.2.6

Peripapillary Retinal Nerve Fiber Layer and Microvasculature in Prolonged Type 2 Diabetes Patients Without Clinical Diabetic Retinopathy Open Access

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Min-Woo Lee; Woo-Hyuk Lee; Cheon-Kuk Ryu; Yong-Min Lee; Young-Hoon Lee; Jung-Yeul Kim

Tags: diabetes mellitus, type 2, diabetic retinopathy, microvascular network, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.2.9

Ametropia and Emmetropization in CNGB3 Achromatopsia Open Access

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Mette Kjøbæk Gundestrup Andersen; Line Kessel

Tags: achromatopsia, refractive errors, refraction, adult

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.2.10

Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study Open Access

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Wenjia Zhou; Jingyan Yang; Qian Wang; Yaxing Wang; Yanni Yan; Shouling Wu; Shuohua Chen; Wenbin Wei

Tags: atherosclerosis, diabetes mellitus, diabetes mellitus, type 2, eye, retinal vasculature

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.2.20

Foveal Differentiation and Inner Retinal Displacement Are Arrested in Extremely Premature Infants Open Access

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Matthew L. O'Sullivan; Gui-Shuang Ying; Shwetha Mangalesh; Vincent Tai; Heena R. Divecha; Katrina P. Winter; Cynthia A. Toth; Xi Chen; for the BabySTEPS Group

Tags: infant, premature, infant, diagnostic imaging, eye

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.2.25

Topographic Distribution and Progression of Soft Drusen Volume in Age-Related Macular Degeneration Implicate Neurobiology of Fovea Open Access

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Andreas Pollreisz; Gregor S. Reiter; Hrvoje Bogunovic; Lukas Baumann; Astrid Jakob; Ferdinand G. Schlanitz; Stefan Sacu; Cynthia Owsley; Kenneth R. Sloan; Christine A. Curcio; Ursula Schmidt-Erfurth

Tags: drusen, volume, age-related macular degeneration, fovea centralis

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.2.26

Choroidal Vascular Abnormalities by Ultra-widefield Indocyanine Green Angiography in Polypoidal Choroidal Vasculopathy Open Access

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Areum Jeong; Jinam Lim; Min Sagong

Tags: eye, indocyanine green angiography, polypoidal choroidal vasculopathy, vascular diseases, pathogenesis

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.2.29

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development Open Access

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Xiaowen Cao; Jianhong An; Yuqing Cao; Juan Lv; Jiawei Wang; Yang Ding; Xinhua Lin; Xiangtian Zhou

Tags: mice, neural development, proteins, retina

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 31. doi:https://doi.org/10.1167/iovs.62.2.31

Retinal Cell Biology

K_ATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia Open Access

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Hong Li; Donglong Chen; Wei Sun; Jiansu Chen; Chang Luo; Heping Xu; Jacey Hongjie Ma; Shibo Tang

Tags: diabetes mellitus, gliosis, inflammation, microglia, pinacidil

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.2.3

Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3 Open Access

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Nicholas J. Esposito; Francesca Mazzoni; Jade A. Vargas; Silvia C. Finnemann

Tags: galectin 3, mice, photoreceptors, mice, knockout, retina

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.2.7

Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1 Open Access

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Fanfei Liu; Shaomin Peng; Ron A. Adelman; Lawrence J. Rizzolo

Tags: phagocytosis, retinal pigment epithelium, proteins, ampk, rna, small interfering

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.2.14

Hypoxia Induces Galectin-1 Expression Via Autoinduction of Placental Growth Factor in Retinal Pigment Epithelium Cells Open Access

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Taku Yamamoto; Atsuhiro Kanda; Satoru Kase; Susumu Ishida

Tags: galectin 1, hypoxia, placenta growth factor, retinal pigment cell

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.2.22

Morphometric Analysis of Retinal Pigment Epithelial Cells From C57BL/6J Mice During Aging Open Access

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Yong-Kyu Kim; Hanyi Yu; Vivian R. Summers; Kevin J. Donaldson; Salma Ferdous; Debresha Shelton; Nan Zhang; Micah A. Chrenek; Yi Jiang; Hans E. Grossniklaus; Jeffrey H. Boatright; Jun Kong; John M. Nickerson

Tags: aging, mice, mice, inbred c57bl, retinal pigment cell, optic disk

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 32. doi:https://doi.org/10.1167/iovs.62.2.32

Visual Psychophysics and Physiological Optics

Vision Impairment Provides New Insight Into Self-Motion Perception Open Access

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Wilson Luu; Barbara Zangerl; Michael Kalloniatis; Stephen Palmisano; Juno Kim

Tags: blindness, glaucoma, motion, perception, visual impairment

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.2.4

Revealing How Color Vision Phenotype and Genotype Manifest in Individual Cone Cells Open Access

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Furu Zhang; Kazuhiro Kurokawa; Marcel T. Bernucci; Hae Won Jung; Ayoub Lassoued; James A. Crowell; Jay Neitz; Maureen Neitz; Donald T. Miller

Tags: color vision, phenotype, retinal cone, genotype, mosaicism

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.2.8

Contrast Rivalry Paradigm Reveals Suppression of Monocular Input in Keratoconus Open Access

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Bhagya Lakshmi Marella; Miriam L. Conway; Catherine Suttle; Shrikant R. Bharadwaj

Tags: balance, device, equilibrium, eye, keratoconus

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.2.12

Letters to the Editor

Image Registration Is Required for Experiments of Accommodation Open Access

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Ronald A. Schachar

Tags: visual accommodation

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.2.17

Author Response: Systematic Imaging Experiments of Accommodation Do Not Require Image Registration Open Access

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Mary Ann Croft; Paul L. Kaufman

Tags: diagnostic imaging, visual accommodation

Investigative Ophthalmology & Visual Science February 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.2.18

Erratum

Erratum in: Long Noncoding RNA OIP5-AS1 Promotes Cell Apoptosis and Cataract Formation by Blocking POLG Expression Under Oxidative Stress Open Access

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Investigative Ophthalmology & Visual Science February 2021, Vol.62, 39. doi:https://doi.org/10.1167/iovs.62.2.39

Erratum in: Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES) Open Access

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Investigative Ophthalmology & Visual Science February 2021, Vol.62, 40. doi:https://doi.org/10.1167/iovs.62.2.40

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