Volume 62 Issue 3 | IOVS

Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma Open Access

Naheed Arfin Borah; Swatishree Sradhanjali; Manas Ranjan Barik; Atimukta Jha; Devjyoti Tripathy; Swathi Kaliki; Suryasnata Rath; Sunil K. Raghav; Srinivas Patnaik; Ruchi Mittal; Mamatha M. Reddy

Tags: apoptosis, cell survival, mycn gene, neoplasms, phosphotransferases

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.3.16

Cornea

Cigarette Smoke Triggers Loss of Corneal Endothelial Cells and Disruption of Descemet's Membrane Proteins in Mice Open Access

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Muhammad Ali; Shahid Y. Khan; Yura Jang; Chan Hyun Na; C. Conover Talbot, Jr; John D. Gottsch; James T. Handa; S. Amer Riazuddin

Tags: cigarette smoke, cornea, endothelial cells, mice, proteins

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.3.3

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade Open Access

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Romina Mayra Lasagni Vitar; Marco Barbariga; Philippe Fonteyne; Fabio Bignami; Paolo Rama; Giulio Ferrari

Tags: aprepitant, cornea, pain, substance p receptor, neurons

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.3.26

Innate and Adaptive Gene Single Nucleotide Polymorphisms Associated With Susceptibility of Severe Inflammatory Complications in Acanthamoeba Keratitis Open Access

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Nicole A. Carnt; Ignatius Pang; Kathryn P. Burdon; Virginia Calder; John K. Dart; Dinesh Subedi; Alison J. Hardcastle

Tags: acanthamoeba keratitis, disease susceptibility, genes, genetics, inflammation

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 33. doi:https://doi.org/10.1167/iovs.62.3.33

Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines Open Access

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Xue Tian; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Ranran Zhang; Guiqiu Zhao

Tags: antifungal agents, anti-inflammatory agents, cytokine, keratitis, mice

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 38. doi:https://doi.org/10.1167/iovs.62.3.38

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses Open Access

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Noriko Nishikawa; Jacqueline Chua; Yuriya Kawaguchi; Tomoko Ro-Mase; Leopold Schmetterer; Yasuo Yanagi; Akitoshi Yoshida

Tags: amblyopia, amblyopia, pediatric, macular vasculature, magnification, eye

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 39. doi:https://doi.org/10.1167/iovs.62.3.39

Glaucoma

Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice Open Access

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Xiaowei Yu; Nannan Sun; Xue Yang; Zhenni Zhao; Xiaoqian Su; Jiamin Zhang; Yuqing He; Yixiu Lin; Jian Ge; Zhigang Fan

Tags: mice, microphthalmos, suspensory ligament of lens, mutation, rna, messenger

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.3.1

A Porcine Organ-Culture Glaucoma Model Mimicking Trabecular Meshwork Damage Using Oxidative Stress Open Access

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Eric J. Snider; Becky A. Hardie; Yinglin Li; Kristin Gao; Fiona Splaine; R. Kijoon Kim; R. Taylor Vannatta; A. Thomas Read; C. Ross Ethier

Tags: glaucoma, hydrogen peroxide, organ culture techniques, suidae, eye

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.3.18

Regional Differences in the Glycosaminoglycan Role in Porcine Scleral Hydration and Mechanical Behavior Open Access

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Mohammad Pachenari; Hamed Hatami-Marbini

Tags: buffers, edema, enzymes, geographic difference, glycosaminoglycans

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.3.28

Immunology and Microbiology

Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor Open Access

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Kexin Li; Xue Feng; Kenji Hikosaka; Kazumi Norose

Tags: aqueous humor, fluorescein angiography, hypertension, immune mediator, infections

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.3.9

Lens

Aquaporins Have Regional Functions in Development of Refractive Index in the Zebrafish Eye Lens Open Access

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Kehao Wang; Irene Vorontsova; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; James Ewbank Hall; Thomas Friedrich Schilling; Barbara Krystyna Pierscionek

Tags: lens (device), lens, crystalline, refractive index, water channels, zebrafish

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.3.23

Multidisciplinary Ophthalmic Imaging

Wide-Field Swept-Source Optical Coherence Tomography Analysis of Interocular Symmetry of Choroidal Thickness in Healthy Young Individuals Open Access

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Min-Su Kim; Hyung-Bin Lim; Woo-Hyuk Lee; Kyeung-Min Kim; Ki Yup Nam; Jung-Yeul Kim

Tags: eye, nose, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.3.5

Changes in Choroidal Component Ratio and Circulation After Coffee Intake in Healthy Subjects Open Access

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Daisuke Nagasato; Yoshinori Mitamura; Mariko Egawa; Fumiko Murao; Toshihiko Nagasawa; Natsumi Komori; Shozo Sonoda; Taiji Sakamoto; Hitoshi Tabuchi

Tags: coffee

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.3.27

Quantification of Retinal Ganglion Cell Morphology in Human Glaucomatous Eyes Open Access

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Zhuolin Liu; Osamah Saeedi; Furu Zhang; Ricardo Villanueva; Samuel Asanad; Anant Agrawal; Daniel X. Hammer

Tags: eye, glaucoma, language morphology, morphology

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 34. doi:https://doi.org/10.1167/iovs.62.3.34

Physiology and Pharmacology

Reduced Oxygen Extraction in the Retinal Periphery When the Arterial Blood Pressure Is Increased by Isometric Exercise in Normal Persons Open Access

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Toke Bek; Signe Krejberg Jeppesen

Tags: arterial pressure, exercise, exercise, isometric, oxygen extraction, oxygen saturation measurement

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.3.11

NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow in HTM/HSC Constructs Open Access

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Elena Bastia; Carol B. Toris; Stefania Brambilla; Corinna Galli; Nicoletta Almirante; Michael V. W. Bergamini; Emanuela Masini; Silvia Sgambellone; Andrea M. Unser; Feryan Ahmed; Karen Y. Torrejon; Tomas Navratil; Francesco Impagnatiello

Tags: animal model, dog, domestic, intraocular pressure, ocular hypertension, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.3.17

Retina

Tear Fluid Angiogenic Factors: Potential Noninvasive Biomarkers for Retinopathy of Prematurity Screening in Preterm Infants Open Access

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Anand Vinekar; Archana Padmanabhan Nair; Shivani Sinha; Tanuja Vaidya; Koushik Chakrabarty; Rohit Shetty; Arkasubhra Ghosh; Swaminathan Sethu

Tags: angiogenesis factor, biological markers, infant, premature, retinopathy of prematurity, screening

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.3.2

Functional Relevance of Hyper-Reflectivity in Macular Telangiectasia Type 2 Open Access

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Simone Tzaridis; Martin Friedlander; for the Macular Telangiectasia Type 2-Phase 2 CNTF Research Group

Tags: eye, ophthalmologists, telangiectasis

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.3.6

Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography Open Access

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Lisette M. Smid; Koenraad A. Vermeer; Tom O. A. R. Missotten; Jan A. M. van Laar; Mirjam E. J. van Velthoven

Tags: angiogram, optical coherence tomography, parafoveal region, uveitis, eye

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.3.8

Exploring the Relationship Between Multilayered Choroidal Neovascularization and Choriocapillaris Flow Deficits in AMD Open Access

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Peter L. Nesper; Janice X. Ong; Amani A. Fawzi

Tags: choroidal neovascularization, fluid flow

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.3.12

Clinical Characteristics of Highly Myopic Patients With Asymmetric Myopic Atrophic Maculopathy–Analysis Using Multimodal Imaging Open Access

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Yun Hsia; Shih-Wen Wang; Chien-Jung Huang; Kuo-Chi Hung; Muh-Shy Chen; Tzyy-Chang Ho

Tags: atrophic condition of skin, eye, macular disorders, multimodal imaging

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.3.21

Choroidal and Retinal Changes After Systemic Adrenaline and Photodynamic Therapy in Non-Human Primates Open Access

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Kai Xiong Cheong; Veluchamy Amutha Barathi; Kelvin Yi Chong Teo; Usha Chakravarthy; Sai Bo Bo Tun; Joanna Marie Busoy; Candice Ee Hua Ho; Rupesh Agrawal; Kanji Takahashi; Chui Ming Gemmy Cheung

Tags: epinephrine, photochemotherapy, primates

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.3.25

Extensive Sub-RPE Complement Deposition in a Nonhuman Primate Model of Early-Stage Diabetic Retinopathy Open Access

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Shuxin Fan; Ziqi Yang; Yan Liu; Jiawei Zhong; Shuyao Zhang; Yuhua Xiao; Xu Liu; Wei Yi; Chang He; Youjin Hu; Xialin Liu

Tags: cercopithecidae, complement system proteins, diabetes mellitus, diabetic retinopathy, primates

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.3.30

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime Open Access

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Eric Seifert; Svenja Rebecca Sonntag; Philipp Kleingarn; Dirk Theisen-Kunde; Salvatore Grisanti; Reginald Birngruber; Yoko Miura; Ralf Brinkmann

Tags: lasers, pigment, epithelium, cell injury

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 32. doi:https://doi.org/10.1167/iovs.62.3.32

Evidence for Structural and Functional Damage of the Inner Retina in Diabetes With No Diabetic Retinopathy Open Access

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Giovanni Montesano; Giovanni Ometto; Bethany E. Higgins; Radha Das; Katie W. Graham; Usha Chakravarthy; Bernadette McGuiness; Ian S. Young; Frank Kee; David M. Wright; David P. Crabb; Ruth E. Hogg

Tags: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, retina

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 35. doi:https://doi.org/10.1167/iovs.62.3.35

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy Open Access

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Hirotsugu Soga; Ryo Asaoka; Kazuaki Kadonosono; Maiko Maruyama-Inoue; Nozomi Igarashi; Marie Kitano; Kohdai Kitamoto; Keiko Azuma; Ryo Obata; Tatsuya Inoue

Tags: autofluorescence, central serous chorioretinopathy, eye, perimetry, diagnostic imaging

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 36. doi:https://doi.org/10.1167/iovs.62.3.36

Retinal Cell Biology

lncRNA Ttc3-209 Promotes the Apoptosis of Retinal Ganglion Cells in Retinal Ischemia Reperfusion Injury by Targeting the miR-484/Wnt8a Axis Open Access

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Ran Zhang; Yuqing Feng; Jinfang Lu; Yanni Ge; Huiling Li

Tags: apoptosis, ischemia, reperfusion therapy, retinal ischemia, physiologic reperfusion

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.3.13

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy Open Access

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Saumik Biswas; Biao Feng; Shali Chen; Jieting Liu; Erfan Aref-Eshghi; John Gonder; Vy Ngo; Bekim Sadikovic; Subrata Chakrabarti

Tags: angiogenesis, diabetes mellitus, diabetic retinopathy, epigenetics, glucose

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.3.20

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells Open Access

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Lorena Teixeira Frasson; Barbara Dalmaso; Priscilla Sayami Akamine; Edna Teruko Kimura; Dânia Emi Hamassaki; Carolina Beltrame Del Debbio

Tags: hmga2 protein, micrornas, stem cells, ciliary epithelium, adult

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 31. doi:https://doi.org/10.1167/iovs.62.3.31

CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization Open Access

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Yamei Zhou; Jia Zeng; Yuanyuan Tu; Lele Li; Shu Du; Linling Zhu; Xiaomin Cang; Jiajie Lu; Manhui Zhu; Xiaojuan Liu

Tags: choroidal neovascularization, endothelial cells, macrophage colony-stimulating factor, macrophage colony-stimulating factor receptor, macrophages

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 37. doi:https://doi.org/10.1167/iovs.62.3.37

Visual Neuroscience

Restoration of mGluR6 Localization Following AAV-Mediated Delivery in a Mouse Model of Congenital Stationary Night Blindness Open Access

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Juliette Varin; Nassima Bouzidi; Miguel Miranda De Sousa Dias; Thomas Pugliese; Christelle Michiels; Camille Robert; Melissa Desrosiers; José-Alain Sahel; Isabelle Audo; Deniz Dalkara; Christina Zeitz

Tags: biopharmaceutics classification system, dendrites, electroretinography, mice, night blindness, congenital stationary

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.3.24

Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1 Open Access

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Jiaheng Xie; Patricia R. Jusuf; Bang V. Bui; Stefanie Dudczig; Tamar E. Sztal; Patrick T. Goodbourn

Tags: electroretinography, genes, genetics, larva, spatial frequency

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.3.29

Visual Psychophysics and Physiological Optics

Binocular Enhancement of Multisensory Temporal Perception Open Access

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Collins Opoku-Baah; Mark T. Wallace

Tags: epidemiologic causality, noise, perception, time perception, total body water

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.3.7

Emmetropic, But Not Myopic Human Eyes Distinguish Positive Defocus From Calculated Blur Open Access

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Barbara Swiatczak; Frank Schaeffel

Tags: eye, retina, optics, myopia, lens (device)

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.3.14

Age-Dependence of the Peripheral Defocus of the Isolated Human Crystalline Lens Open Access

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Bianca Maceo Heilman; Ashik Mohamed; Marco Ruggeri; Siobhan Williams; Arthur Ho; Jean-Marie Parel; Fabrice Manns

Tags: lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.3.15

Review

Mitophagy: An Emerging Target in Ocular Pathology Open Access

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Jessica M. Skeie; Darryl Y. Nishimura; Cheryl L. Wang; Gregory A. Schmidt; Benjamin T. Aldrich; Mark A. Greiner

Tags: dna, mitochondrial, mitochondria, pathophysiology, proteins, pathology

Investigative Ophthalmology & Visual Science March 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.3.22

Erratum

Erratum in: Location of Parapapillary Gamma Zone and Vertical Fovea Location. The Beijing Eye Study 2011 Open Access

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Investigative Ophthalmology & Visual Science March 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.3.4

Erratum in: Peripapillary Retinal Nerve Fiber Layer and Microvasculature in Prolonged Type 2 Diabetes Patients Without Clinical Diabetic Retinopathy Open Access

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Investigative Ophthalmology & Visual Science March 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.3.10

Erratum in: S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway Open Access

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Investigative Ophthalmology & Visual Science March 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.3.19

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